Database Description

General information of database
Database name	PoSSuM
Alternative name	Pocket Similarity Search using Multiple-Sketches
DOI	10.18908/lsdba.nbdc01144-000
Creator	Creator Name Kentaro Tomii* Creator Affiliation Tokyo Waterfront, the National Institute of Advanced Industrial Science and Technology (AIST) Literature Search
Contact address	2-4-7 Aomi, Koto-ku, Tokyo, 135-0064 Japan National Institute of Advanced Industrial Science and Technology (AIST) Kentaro TOMII, PhD
Database classification	Structure Databases - Small molecules
Database description	PoSSuM is a database for detecting similar small-molecule binding sites on proteins. We have provided a service named PoSSuM drug search, in which we selected 194 approved drug compounds retrieved from ChEMBL, and detected their known binding pockets and pockets that are similar to them.
Features and manner of utilization of database
License	CC BY-SA Detail
Background and funding	Japan Society for the Promotion of Science (JSPS) [KAKENHI 23500374]; Grants-in-Aid for Scientific Research [25430186 and 25293079]; Platform for Drug Discovery, Informatics, and Structural Life Science from the Ministry of Education, Culture, Sports, Science and Technology, Japan; Grants-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare
Reference(s)	Article title PoSSuM v.2.0: data update and a new function for investigating ligand analogs and target proteins of small-molecule drugs. Author name(s) Ito J, Ikeda K, Yamada K, Mizuguchi K, Tomii K. Journal Nucleic Acids Res. DB issue 2015;43:D392-8. External Links Article title PoSSuM: a database of similar protein-ligand binding and putative pockets. Author name(s) Ito J, Tabei Y, Shimizu K, Tsuda K, Tomii K. Journal Nucleic Acids Res. DB issue 2012;40:D541-8. External Links Article title PDB-Scale analysis of known and putative ligand binding sites with structural sketches. Author name(s) Ito J, Tabei Y, Shimizu K, Tomii K, Tsuda K. Journal Proteins 2011;80:747-63. External Links Article title Single Versus Multiple Sorting for All Pairs Similarity Search. Author name(s) Tabei Y, Uno T, Sugiyama M, Tsuda K. Journal The 2nd Asian Conference on Machine Learning (ACML2010) 2010.
Original website information
Database maintenance site	Artificial Intelligence Research Center (AIRC), The National Institute of Advanced Industrial Science and Technology (AIST)
URL of the original website	http://possum.cbrc.jp/PoSSuM/index.html
Operation start date	2011/11/01
Last update date	2014/10/15
URL of the portal site	-
Whole data download	-
Referenced database	PDB, UniProt, ChEMBL, EC, CATH, SCOPe, GO
Entry list	Not available
Query search	Not available
Web services	Not available
URL of Web services	-
Need for user registration	Not available