| LEF1's Target genes |
|
◢ LEF1: Average |
| ◢ SRX702032: hESC derived mesendodermal cells |
◢ SRX702033: hESC derived mesendodermal cells |
◢ SRX833400: hESC H1 |
◢ SRX1225022: RL95-2 |
◢ SRX1225023: RL95-2 |
◣ SRX1225024: RL95-2 |
◢ SRX1225025: RL95-2 |
| ◢ LEF1: STRING |
| KIF5C |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RGPD2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RGPD1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MTRNR2L2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MSH3 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| DHFR |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MTRNR2L9 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MTRNR2L8 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MAMDC2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PMF1-BGLAP |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PMF1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| LOC102724770 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| DGCR6 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MTRNR2L1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| WDR74 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| STX5 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TRIM48 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| DUX4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MUC3A |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| EMILIN2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MTRNR2L10 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PTPRN2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| UNC45B |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NLE1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ADAMTS9 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PHRF1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TSNAXIP1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RANBP10 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| FRG2C |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CCDC200 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| FRG2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MTRNR2L6 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PPP6R2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| UNC119 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RAB22A |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ART1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ARF1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PER3 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SEMA4F |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| M1AP |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| FAM86B1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SLC25A1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NRBP2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| KLF16 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| P4HB |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| POLD1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NR1H2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TTC12 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TSEN54 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| LLGL2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SLC66A1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| AKR7A2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| OGFOD2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ABCB9 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CHID1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RAB11FIP4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| FAM210B |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| HSP90AA1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| GATD1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SPC25 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| LHX6 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| UBE2T |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PPP1R12B |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| COL23A1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SARAF |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TBL2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| INPP5A |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ETS1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CTF1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| BCL7C |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| UBE3C |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MAF1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| GLRX5 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CYC1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| DRD4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| JOSD2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ASPDH |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PHF19 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| GRK6 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TSSC4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ARSA |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ZFPM1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SNRPD3 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| GUCD1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CIC |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| OPLAH |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TMPRSS11E |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| KMT2A |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| REST |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ZNF76 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SP5 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| KIAA1522 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ZPLD1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| METTL11B |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CUEDC2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SERINC5 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CCDC183 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CDX2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| HSPE1-MOB4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| HSPE1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| HSPD1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CPPED1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ZBTB8OS |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RBBP4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SNX16 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| FAM72C |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| FAM72A |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SNX12 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RABL6 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CADPS |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| DMXL1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NEK2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CREB5 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| AMOTL2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| AXIN2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SVEP1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ADI1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ZNF285 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TREX1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SHISA5 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SCRT2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ARHGEF38 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NOG |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TACC1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NOTCH2NLC |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NOTCH2NLB |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NOTCH2NLA |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MUC2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ANTXR2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NOTUM |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ASPSCR1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ETV4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SRD5A3 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ABCA4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PPP1R16A |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| FOXH1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RCAN1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| FAM72B |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NODAL |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SMPD3 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ZNF703 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| FAM72D |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CD82 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MED1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ARID3A |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PFDN4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| P2RY12 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ACVR1C |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SMARCA2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| HOXA1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| URM1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SSB |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SPECC1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NXF1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MYO9B |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| HAUS8 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SYNPO2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MUC1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SMURF2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| HINT3 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PALM2AKAP2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PAAF1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| COA4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| OGA |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CSK |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RFXANK |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| BORCS8-MEF2B |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| BORCS8 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ZNF7 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NBPF1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| LRATD2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TMPO |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MKLN1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| UCN2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PFKFB4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ARFGAP3 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| AAAS |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ZNF517 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ZNF34 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RPL8 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CYB5R1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ADIPOR1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| VPS37D |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PDE4B |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| STX3 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| FAM174B |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TLE6 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PDE4D |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MRAS |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| KBTBD8 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NOTCH2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NUDT4B |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| NUDT4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MSH2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RMND5B |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TCTA |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RHOA |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ZNF335 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TMEM18 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| KMT5B |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| LIG3 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| BFSP1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| GUK1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| GJC2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TRAPPC9 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| KIFBP |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ZSWIM4 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| DIO1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CHAMP1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PLAGL1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| GNAI2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| UCKL1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| RBBP5 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| BAG2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| IQSEC3 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| TMEM141 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| SLC4A2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| CDK5 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ASIC3 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| PRICKLE1 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| ZNF473 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| VRK3 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |
| MICALL2 |
↻ |
|
|
|
|
|
|
|
|
|
|
≫ |