We extracted synonyms described in databases such as Entrez Gene, Swiss-Prot and HGNC.

1. Collect gene names automatically from synonym information fields in various gene/genome databases.
2. The curators who have expertise in biological research confirm the name variation for genes and associate them. They also delete names which are confusing to associate (polysemy, acronyms for different genes etc.).
3. Extract words describe gene names from MEDLINE abstracts and collect unregistered names.
4. Evaluate detection performance of gene names in the dictionary.
5. Add non-detected words to the dictionary and repeat 4-5 using other literature set.