AɂČɍphasiRNA̎YoHы@\

<strong>쐹YEX</strong>
i`w AזE`j
emailF<a href="mailto:knonomur@nig.ac.jp">X</a>
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̈Zr[, <strong>8</strong>, e002 (2019)@<a href="http://dx.doi.org/10.7875/leading.author.8.e002">DOI: 10.7875/leading.author.8.e002</a>
Seijiro Ono & Ken-Ichi Nonomura: <strong>Biogenesis and function of plant reproductive phasiRNAs abundantly expressed in meiotic stages.</strong>

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<h2>v </h2>
@́CeɗRF̂VȈ`q̑gnoCF̂̐\ĎSC`̍ȂۂłD܂łɁCs΍̈ɕz`q̔}CpiRNAɂ鐶BזEnɂgX|]̗}ȂǁCBזE̔⌸̐isƏqRNAɈˑIȃGsWFleBbNȋ@\Ƃ̊֘Ãfɂĕ񍐂ĂDApiRNA͕ۑĂȂCߔNCPqtA̐B튯ɂč2124siRNAƂphasiRNACBזȄ̔𐧌䂷\̂鏬qRNAƂĒڂĂDphasiRNȂÔƂȂlncRNÁCÃQmɂĐS琔炩̈`q̈悠邢͈`qԗ̈ɕzDORNARNA|[[IIɂ]ʂꂽ̂C22miRNAArgonauteƂ̂̕ɂ1ؒfCRNAˑIRNA|[[ɂ2{C{kNA[[IIIlyfłDCLɂmiRNAɂؒfʂN_Ƃ21邢24̊Ԋuł̐ؒfւāCnphasiRNAYD̃r[ɂẮCɌɍphasiRNAɂāCYoH┭̎ԓIȐCݍpArgonaute̎ނы@\ȂǂCɂpiRNA̎YoHƂ̔rCAɓIȐBVXeԂ肾Ƃ݂D

<h2>͂߂</h2>
@́CLBsׂĂ̐^jɕۑCB̉ߒɂ钆SIȃCxĝЂƂłDɂg͗eɗRF̂VȈ`q̑gnoւƓ`BDɁC͑F̂̑΍F̂̐э\̊ĎSDƂ΁CqEƃCI1Gł郌I|ɐB\͂Ȃ̂́Ce̐F̂̐э\̈Ⴂɂ錸ɂF̂̑΍ُ̈킪ƂD̂悤ɁC͎̈`Iȑlɋ@\ƂƂɁCF̂̐э\̔FԂ̈`q̌𐧌̈ێɍvD
@̃r[ɂ邨ȃgsbNł鏬qRNAƌƂ̊֘Amꂽŏ̂́CAJpJr̕s΍̈ɂ`q̔}̌ł<a href="#R1"><sup>1,2)</sup></a>C}EXɂĂގ̌ۂ񍐂ꂽ<a href="#R3"><sup>3,4)</sup></a>DAɂẮCŋ߁CB̉ߒɂċ@\鏬qRNAɊւ񍐂DƂɁCԕɂĐIȌCɂĂ͂ق̂ꂽr[QƂ<a href="#R5"><sup>5)</sup></a>C̃r[ɂẮCɍ鏬qRNÂЂƂphasiRNA̎YoHɂāCAɓIȐBVXe̐܂ĉCpiRNAƂ̔rC܂ɑ̓cAphasiRNA̖ɂčl@D

<h2>1Dɂ݂AƓ̐Bl̈Ⴂ</h2>
@ghƂt̐Bwɂ^̈Ӗm낤H@BwɂẮCeqƂʓIȗp@Ƃ͈قȂC̐ɏoقȂ鐶Bl̂ꂼ<a href="#R6"><sup>6,7)</sup></a>Dqg܂ߑ̓ɂẮCɂ萶זE͂̂܂ܔzqւƐn邽߁C͔̑̂zq𐶂ݏoẑƒ`CɌ鐶B͔źiLBĵ݂łDCǍɂ萶זEiEqj́C̍זEւđזE̔źiqAɂẮCԕ̂jƂȂC̓ɔzq`i<a href="#F1">}1</a>jDẑ́CѐAɂĂƂɗLBɕނDCꂪʏڂɂqȂ̂́CźiEqɗRj𖳐Iɂ肾́CȂ킿CEq̂ƂĖBɒ`D̂悤ɁCA͖ƗL2ނ̐Bオ̐Ɍ݂Ɍ鐢ƂD܂CBl̊ϓ_C̐BזE̔ƔrA̔̉ߒ́Ĉ̂󐸂ɂĂ̔ẑ̌`̉ߒłCAɂƂC͖B̍Ō̃CxgłD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@qA̐ɂ݂鐢</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2019/01/Nonomura-8.e002-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2019/01/Nonomura-8.e002-Fig.1.png&amp;caption=fig1-caption-text]

@̃r[ɂœ_ł鐶BɓٓIȏqRNAƂāCɂĂpiRNAiPIWI-interacting RNAj肳CɌĂDpiRNÁCBזEnɂăgX|]sSȃQmɓ`B邱Ƃ`IȖƍlĂD̂悤ȃVXeׂ͂Ă̐ɕsȂ͂CApiRNA̎YoHɗގqRNA̎YoHCсCpiRNAƌPIWIt@~[ɑArgonauteiAGOjۑĂȂ<a href="#R8"><sup>8-10)</sup></a>D̎́CAɓL̐B𔽉fĂ̂ȂD̈ŁCAɂČזEт̌זEɂ́C􂠂邢̗͂̂̂LBiẑ̌`j̉^E`qCсCqRNA܂ޔR[hRNAĂ<a href="#R11"><sup>11-13)</sup></a>C炪piRNAɑ@\S\͏\ɍlD

<h2>2DAɓIsiRNAłphasiRNA</h2>
@qRNA20`30RNAłCKChRNAƂArgonauteɎ荞܂RISCiRNA-induced silencing complexjƂ΂镡̂`CzɈˑIɓ]ʌ゠邢͓]ʂ̃xɂĈ`q̔}ɋ@\D]ʌ}ɂẮCRISCWIƂȂmRNAƌĐؒf|̗}sD]ʗ}́CRISCWIƂȂN}`̈RNA邢DNAČC̗̈̃N}`ɏCЂN@\łDAɂ\Iȓ]ʗ}ƂRNAˑIDNA`mĂ<a href="#R14"><sup>14)</sup></a>DʂɁC]ʌ}͍זEɋǍ݂ArgonauteC]ʗ}͊jɋǍ݂ArgonauteCꂼs<a href="#R15"><sup>15)</sup></a>D̏qRNÁCmiRNAimicroRNAjCsiRNAismall interfering RNAjCāCB튯ɂċ@\piRNA3ɑʂDƂɁCpiRNA܂ޏqRNA̎YɂẮC<a href="http://leading.lifesciencedb.jp/7-e003/" target="_blank"> ޒÎqE KG, ̈Zr[, <strong>7</strong>, e003 (2018)</a> QƂꂽD
@ApiRNAȂŁCphasiRNAiphased secondary siRNAjƂ΂ƎsiRNA𔭒BDphasiRNÁC`q̈悠邢͈`qԗ̈悩RNA|[[IIɂ]ʂlncRNAilong non-coding RNAjÔƂ<a href="#R10"><sup>10)</sup></a>i<a href="#F2">}2a</a>jD̑ORNA<em>PHAS</em> RNACRQm̈<em>PHAS</em>ƂԁDphasiRNA̎ÝC<em>PHAS</em> RNA5f[邢̖͗[ɕۑWIzC22miRNAAGO1邢AGO7Ƃ̂ؒ̕f1ؒfɂ͂܂Dؒfꂽ1{<em>PHAS</em> RNÁCRNAˑIRNA|[[łRDR6ɂ2{D̂̂CmiRNA̐ؒfʂN_ƂāC{kNA[[IIIl̍yfłDCL4邢DCL5C2{<em>PHAS</em> RNA21iDCL4j邢24iDCL5j̓Ԋu2ؒf邱ƂɂCphasiRNAYD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@AɓƎsiRNAłphasiRNA</strong>
iajBphasiRNA̎YoHDPol IIFRNA|[[IID
ibjClɂ<em>PHAS</em>̕zD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2019/01/Nonomura-8.e002-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2019/01/Nonomura-8.e002-Fig.2.png&amp;caption=fig2-caption-text]

@phasiRNÁC<em>PHAS</em>̃ZXуA`ZX̗ɁC21邢24̈ʑă}bvĂD悭^fs[gƌ邪C<em>PHAS</em>ɂĂphasiRNÂɔz̕ۑ͂ȂCꂼꂪj[NȔzƂă}bvꍇD24phasiRNȂÔR[h24-<em>PHAS</em>̓Cl̃Qm100ȏC21phasiRNȂÔR[h21-<em>PHAS</em>ɂĂ1000ȏオ肳Ă<a href="#R16"><sup>16-18)</sup></a>i<a href="#F2">}2b</a>jDl̃p^[̂tasiRNAi<em>trans</em>-acting siRNAjDtasiRNA͐Ajuvenile-adult]܂ޔ̉ߒɂďdvȖ͂siRNAƂāCȑOɕ񍐂Ă<a href="#R19"><sup>19)</sup></a>D̎YoHphasiRNAƗގ邪CtasiRNA̎YoHɂĂ͑ÔƂȂlncRNA10ނƏȂC̈`qmRNAɃgXɍp<a href="#R20"><sup>20)</sup></a>DphasiRNA̓VXуgX̗ōpsiRNA܂ޗpł邱ƂCtasiRNAphasiRNÄƂĒ`邱ƂĂĂ<a href="#R10"><sup>10)</sup></a>D

<h2>3DA̐B튯ɂĖLxɔphasiRNA</h2>
@phasiRNA͉ԏgDɖLxɑ݂siRNAƂāCClɂčŏɕ񍐂ꂽ<a href="#R16"><sup>16)</sup></a>D̂̂Cԏ̂ƂɗYׁiށjɂĖLxɔ邱ƁC1ؒfAGO122miRNAimiR2118邢miR2275jC2ؒfRDR6DCL4邢DCL5Ɉˑ邱Ƃ񍐂<a href="#R21"><sup>21,22)</sup></a>CphasiRNAƂĒ`ꂽDȂCB튯ȊOɂphasiRNA̕񍐂邪CƂɒPqtAł͐B튯ɂčꍇ߁C̃r[ł́CƂɒfȂ萶BphasiRNAireproductive phasiRNAjphasiRNAƂԁD
@gERVуClɂẮCނ̔BiKɂphasiRNA̎ԓIȔp^[炩ɂĂ<a href="#R23"><sup>23,24)</sup></a>D21phasiRNA͌̂܂猸ɂނɖLxɔC24phasiRNA͌ɂăs|Cgɔi<a href="#F3">}3</a>jDCľނɂČo鏬qRNÂCgX|]ӂނԂzɗRsiRNAŜ̖75߂邪CɂÂ21phasiRNA24phasiRNAꂼ156݂<a href="#R18"><sup>18)</sup></a>D

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@ClɂnBזȄ̕猸ɂĂނ̔phasiRNA̔</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2019/01/Nonomura-8.e002-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2019/01/Nonomura-8.e002-Fig.3.png&amp;caption=fig3-caption-text]

@tȂǂ̕\ɔHD-ZIP IVt@~[̓]ʈqłOCL4̋@\ψّ̂ނɂāC21phasiRNA̔ʂIɌƂC21phasiRNAт̑Ôނ̕\ɂĔ\ꂽ<a href="#R23"><sup>23)</sup></a>D24phasiRNÁCނ̂Y̌זEƂ肩ރ^y[gwƂ΂̍זEgDɂēٓIɔ邱Ƃꂽ<a href="#R18"><sup>18,23)</sup></a>i<a href="#F3">}3</a>jD^y[gזE͌̂̂Ɍ`Eqɉԕk̍ޗh{邪Cɂ@\͕słD̂ɏqׂ悤ɁCŋ߁CM҂̌O[vɂC^y[gwɂēٓIɔ@\bHLH^̓]ʈqCɓٓI24phasiRNA̎Y邱Ƃ炩ɂꂽD
@BphasiRNÁCClgERVɂ킦CߔNł́CJWOT<a href="#R25"><sup>25,26)</sup></a>CCAXpKX<a href="#R27"><sup>27)</sup></a> Ȃǂ̒PqtAɂĂŕ񍐂ĂDC}ȂȂǑoqtAɂẮCh{ɓ̈`q̈悩phasiRNAY邪CB튯ɂLxȔ͕񍐂Ă炸C܂C\IȃfAłVCkiYiɂĂtasiRNAȊOɖĂphasiRNA͌oȂ<a href="#R28"><sup>28)</sup></a>CBphasiRNǍ͂ɒPqtAɂĐiłD

<h2>4DphasiRNA̕q@\</h2>
@BphasiRNA̕q@\ɂĂ͂܂ɂ悭킩ĂȂDphasiRNA̔z̎ނcł邱ƂWIƂȂRNA̗\ނłDCl̃Qm21-<em>PHAS</em>1000ȏ݂<a href="#R16"><sup>16,17)</sup></a>C͍v2ވȏphasiRNA̎Y܂D24-<em>PHAS</em>100܂肾<a href="#R18"><sup>18)</sup></a>Cł܂24phasiRNA̎ނ͖cłDWIƂȂRNÃQmChȗ\<a href="#R29"><sup>29)</sup></a> C@BwKɂ\<a href="#R30"><sup>30)</sup></a> ݂Ă邪CphasiRNA̔z񂩂͕WIƂȂRNA̖Ăȓɂ͂ĂȂD܂CقsiRNAƔrāCphasiRNA̓j[NȈ`qԗ̈ɗRXꂽ<a href="#R18"><sup>18,23,30)</sup></a>DphasiRNÂ̂悤Ȑ́CRNA|[[IVɈˑIsiRNA <a href="#R31"><sup>31)</sup></a>Cepigenetically activated siRNAieasiRNAjȂ<a href="#R32"><sup>32)</sup></a>C̈`q邢̓gX|]WIƂÂقsiRNA̐Ƃ͈悷D
@̒m𑍍ƁCphasiRNA͊jɂĎ̗R̈CȂ킿C<em>PHAS</em>̓]ʗ}ɍp\߂čDCgERV21-<em>PHAS</em>24-<em>PHAS</em>̎ӂ́CނїYזEiԕזEjɂDNÃ`CƂCHH`iHFACTCGjtȂǂ̉h{튯荂XĂ<a href="#R33"><sup>33)</sup></a>DAsiRNÁCRNAˑIDNA`ɑ\]ʗ}ɋ@\邱ƂmĂ<a href="#R14"><sup>14)</sup></a>CphasiRNAB̉ߒɂēľoHɑgݍ܂Ă\͏\ɍli<a href="#F4">}4</a>jD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@\z鐶BphasiRNA̓]ʌ㐧䂨ѓ]ʐ</strong>
MFDNA`D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2019/01/Nonomura-8.e002-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2019/01/Nonomura-8.e002-Fig.4.png&amp;caption=fig4-caption-text]

@phasiRNÁgsecondaryhƂ́CmiRNAɂ1ؒfւDCLɂ2ؒfɂY邱ƂɂȂށDCClgERV21-<em>PHAS</em>̂Ȃɂ́CmiR2118ɂ1ؒfʂ͂܂ʑɂ܂phasiRNÂقC̈ʑ9ꂽʑsiRNAo<a href="#R34"><sup>34)</sup></a>D́CphasiRNAɂ21-<em>PHAS</em> RNA3ؒfNC炳DCL4ɂAؒf͂܂ƍlƂ܂DȂ킿CphasiRNA͓]ʐւ̊֗^̉\ɂ킦C<em>PHAS</em> RNAWIƂ]ʌ}ɂCꎩ̂̑TCN𑣐i\񏥂Ăi<a href="#F4">}4</a>jD

<h2>5Dɂċ@\AArgonaute</h2>
@ArgonautéCVCkiYiɂ10ށCClɂ19ށCgERVɂ17ނۑCAGO1/5/10t@~[CAGO2/3/7t@~[CAGO4/6/9t@~[ɕނ<a href="#R35"><sup>35)</sup></a>DB̉ߒɂ֗^̒mArgonauteAGO4/6/9t@~[AGO1/5/10t@~[ɑ܂܂邪iphasiRNA̎Yɂ1ؒfsArgonaute͏jC͂PIWIt@~[ɂ͑ȂD
@VCkiYiAGO9iAtAGO9j́CɃgX|]ɗR24siRNAƌ<a href="#R36"><sup>36)</sup></a>DAtAGO9͎זE̊jюזEގS\̍זEɋǍ݂<a href="#R36"><sup>36,37)</sup></a>Cאڂ̍זEזEɂȂ邱Ƃ}<a href="#R36"><sup>36)</sup></a>DgERVAGO104iZmAGO104jAtAGO9̃zOłCψّ̂ނɂĂ͌̒~⌸F̂̒EÏkȂǂُ̈킪C܂Cׂ̑łُ͌̈ɂƂȂҌ̔zq̌`ώ@<a href="#R38"><sup>38)</sup></a>DVCkiYiAGO4iAtAGO4j͐čPIɔ邪Cψّ̂ɂĂ͉ԕזEɂ錸F̂̒EÏkCz̒x؁CˋȂǂُ̈킪N<a href="#R39"><sup>39)</sup></a>DAtAGO4CAtAGO9CZmAGO104͂AGO4/6/9t@~[ɑCƂAtAGO4RNAˑIDNA`oHɂĒSIȖSƂCRNAˑIDNA`oHƂ̖ڂȊ֘AD
@ClMEL1iOsMEL1j́CY̖EqזEƖEq`זEiCזEɕזEjьזEɂēٓIɔArgonautełC̕ψّ̂ɂĂ͌F̂̋Ïkɒ~ĊSsɂȂ<a href="#R8"><sup>8)</sup></a>DOsMEL1̃I[\OłVCkiYiAGO5iAtAGO5jɂẮCԕ̐זEюS\ɂ锭񍐂Ă<a href="#R40"><sup>40,41)</sup></a>DCAtAGO5̃h~iglKeBuψّ̂͌̒ɂĖEqُ̔ƂȂ邪C@\^ψّ̂͌ɂČȕ\^Ȃ<a href="#R41"><sup>41)</sup></a>DAGO1/5/10t@~[ɑCl5ArgonautêCOsMEL1ނюׁCOsAGO12ނɓٓIɁCOsAGO14ׂ͎ɓٓIɔȂ<a href="#R9"><sup>9)</sup></a>CAGO1/5/10t@~[͐BɓٓIɋ@\ArgonauteƂċ@\\D
@_ł́CBphasiRNAƂ̌mɎꂽArgonaute̓ClɂOsMEL1݂̂łDOsMEL15f[CłsiRNAƌX<a href="#R17"><sup>17)</sup></a>D܂猸ɂāC21phasiRNAƌC̊͌邷ׂĂ̏qRNA̖60ɂ<a href="#R17"><sup>17,18)</sup></a>DOsMEL1͌24phasiRNAƂ邪C邷ׂĂ̏qRNA1ł<a href="#R18"><sup>18)</sup></a>ĎʂCOsMEL15f[Cł21phasiRNAɍnD\DCނɂĔsiRNÅ𔽉fʂꂸCCOsMEL1ƌ鏬qRNAɂ̓gX|]ӂނԂzɗRsiRNA20x܂܂Ă<a href="#R17"><sup>17,18)</sup></a>CphasiRNAȊOsiRNAOsMEL1Ƃ̌̏dvےłȂD

<h2>6DphasiRNAזEԃVOiqƂċ@\\</h2>
@̕ˏp^[t̕\p^[̌`ɂāCqRNA͍זÊړCזE񎩗IȈ`q̔}gD̕Ɋ^<a href="#R42"><sup>42,43)</sup></a>D܂CECXɊAɂāCqRNA͑SgRmۂ̃VOiqƂĈۊǑĒA<a href="#R44"><sup>44)</sup></a>DזÊڍs鏬qRNA͓]ʐ䂨ѓ]ʌ㐧ɂċ@\邱ƂĂCsiRNAɂẮCRNAˑIDNA`oHɂזE񎩗I<em>GFP</em>`q̓]ʗ}ЂN<a href="#R45"><sup>45)</sup></a>D
@ߔNCphasiRNAA̐B튯ɂזEԃVOiqƂċ@\\サĂDgERVނɂẮCψّ̂̉͂phasiRNA̎YoHɂĂ͂炭DCL̈`q̑gDِC2124phasiRNA͂ꂼ\炨у^y[gwɈˑIɎY\ꂽCɂ킦CÔƂȂ<em>PHAS</em> RNADCLقƂǔȂ͂̉ԕזEɂĐnphasiRNA̍oĂ<a href="#R23"><sup>23)</sup></a>D܂C@BIɒoԕזEpgXNvg[͂ɂĂʂphasiRNAoꂽ<a href="#R33"><sup>33)</sup></a>DM҂̌O[v́CClɂă^y[gw̕ɏdvȖ͂]ʈqTIP2EAT1CɂēٓIɔ24-<em>PHAS</em> RNA̓]ʂ𒼐ړIɊ邱Ƃo<a href="#R18"><sup>18)</sup></a>DTIP2EAT1́CphasiRNA2ؒfɂ͂炭DCL5R[h`q̓]ʂ邱ƁC܂CTIP2EAT1ƂɃ^y[gזE̊jɓٓIɋǍ݂邱ƂC24phasiRNA̎Yނ̃^y[gזEɂĊƐ@ꂽi<a href="#F5">}5</a>jDCClɂĉԕזÊ݂ɑ݂OsMEL1ƌ鏬qRNÂȂɁC^y[gזEɂĎY͂24phasiRNAoꂽ<a href="#R18"><sup>18)</sup></a>DgERVуClɂ錋ʂ́C24phasiRNÃ^y[gזEԕזEւ̍זÊ̈ڍs̉\xꂽD

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@ނ̃^y[gזEɂĎY24phasiRNA̍זEԈڍs̉\</strong>
Cl̃^y[gזEɔbHLH^̓]ʈqłTIP2EAT1́CʂbHLH^̓]ʈqłUDT1Ƃꂼʑ̂`C24-<em>PHAS</em> RNAт̃vZVOɕKvȃ{kNA[[IIIlyfR[h<em>DCL5</em>`q̓]ʂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2019/01/Nonomura-8.e002-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2019/01/Nonomura-8.e002-Fig.5.png&amp;caption=fig5-caption-text]

@̂܂̉ԕזEɂẮCזEɋǍ݂OsMEL124phasiRNA̔Jn錸ւ̈ڍsɊjɂǍ݂邱<a href="#R17"><sup>17,18)</sup></a>C܂CqXgH3Lys9̍L͈͂ȃW`F̂̋Ïk𑣐i邱Ƃ<a href="#R46"><sup>46)</sup></a>COsMEL1jɂċ@\\DAtAGO424siRNAƌƍזEjւƋǍ݂ω邱<a href="#R47"><sup>47)</sup></a>C<em>mel1</em>ψّ̂ɂĂ͐F̂̋Ïkُ̈ɂ茸􂪑ɒ~邱<a href="#R8"><sup>8)</sup></a>C<em>eat1</em>ψّ̂ɂĂ͐F̂̕IȋÏkُ̈ƂȂ̐is̒xώ@邱<a href="#R18"><sup>18)</sup></a>CȂǂl킹ƁCOsMEL124phasiRNAF̂RNAˑIDNA`ɋ@\\ÎD[CԕזEꎩ̂phasiRNAYIɌ𐧌䂷\͂̌ʂSɂ͔ے肳ꂸC24phasiRNA̐isɊ^邱ƂړIȌʂĂȂ߁CCȂ錟؂KvłD

<h2>7DphasiRNA̐i</h2>
@phasiRNAɊւ͔NXÂĂ邪C炪ǂ̂悤ɐîɂĂ͂܂ɓłD21phasiRNA̎YɏdvDCL4́CAɂčLۑĂ<a href="#R48"><sup>48)</sup></a>DqÃIEVEgEqi<em>Picea abies</em>jɂẮCaQRɂNB-LRRt@~[Ȃǂ̈`q̈您єR[ḧɗR2ނ21phasiRNA݂C҂͂ƂɐB튯ɂč<a href="#R49"><sup>49)</sup></a>DC}ȂiXȂȂǐ^oqtA21phasiRNA͑<em>NB-LRR</em>`q̈ɗR<a href="#R28"><sup>28,50,51)</sup></a>D𑍍ƁCqA邢͌nIȑoqtވȑO2ނ21phasiRNA킹C^oqtނђPqtނ݂͂̈̂󂯌pCPqtނ󂯌pR[ḧɗRphasiRNABזEɓٓIɔ悤ɂȂ\<a href="#R49"><sup>49)</sup></a>DC2ނphasiRNAꂼƗɐîC邢́Cĥ͂͂肵ȂD
@C24phasiRNÁCBȊO̔̉ߒɂĂ͈ꕔ̑oqtAɂĂ񍐂邪<a href="#R52"><sup>52,53)</sup></a>CmiR2275DCL5ƂɒPqtAȊOł͌oȂƂC24̐BphasiRNA͒PqtÂ̂̕ɏo\<a href="#R23"><sup>23)</sup></a>D

<h2>8DpiRNAphasiRNA̔r</h2>
@̓ɂpiRNA̎YoH́C1piRNAYoHƁCs|TCNƂ΂2piRNAoHƂɋʂi<a href="#F6">}6</a>jDiރVEWEoGу}EXɂĊ{IȌoH͋ʂĂ邪Cȉł́C}EXɂpiRNA̎YoHƐAɂ鐶BphasiRNA̎YoHrD

<a name="F6"></a><div id="fig6-caption-text" style="display: none;"><strong>}6@}EXɂpiRNA̎Y</strong>
iajpiRNA̎YoHD
ibjq̌`̉ߒɂpiRNA̗̔lD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2019/01/Nonomura-8.e002-Fig.6.jpg" target="_blank">[Download]</a></div>[hs_figure id=6&amp;image=/wordpress/wp-content/uploads/2019/01/Nonomura-8.e002-Fig.6.png&amp;caption=fig6-caption-text]

@piRNA̎YoHƔrۂ́CAɂ鐶BphasiRNA̎YoH̍{IȈႢ́CÔƂȂlncRNA2{RNAˑIRNA|[[̑݁CсCDCLɂ2{RNA̘AIԊuȐؒfC2_ɏW񂳂D}EXɂ1piRNAYoHɂẮCRNA|[[IIɂ]ʂꂽ1{piRNAÔCGhkNA[[MitoPLDɂU̒OŐؒfi<a href="#F6">}6</a>jD̂̂C5f[URNAɚnDMILI邢MIWIiBזEɂċ@\PIWIt@~[ArgonautejؒfꂽRNA5f[ی삵C3f-5fGL\kNA[[łPNLDC1ɂ3f[̃g~OւāC1piRNAn<a href="#R54"><sup>54,55)</sup></a>DMitoPLDɂؒfʂ̉ɂĂl̂ƂԂ邽߁CЂƂ̑ORNA畡piRNAY<a href="#R56"><sup>56,57)</sup></a>iphased piRNAoHjDł͏ڍׂ͏ȂCs|TCNRNAˑIRNA|[[ȂɓLpiRNȂVXełDߔNCs|TCNɂphased piRNAoH^\񏥂Ă<a href="#R58"><sup>58)</sup></a>D
@phased piRNAoH́CCAɂ鐶BphasiRNA̎YoHƎĂDCpiRNA̎YoHɂĂArgonauteƃGhkNA[[Ƃ1{RNAؒf邽߁CpiRNA5f[PIWIt@~[Argonaute̚nD𔽉fi<a href="#F6">}6</a>jDCA̐BphasiRNA̎YoHɂẮCDCLPƂ2{RNAؒf邽߁CYꂽphasiRNA5f[̉̂͂ȂDphasiRNAoHɂĂArgonautemiRNAƂƂ1ؒfNC܂DCLɂؒf̋N_߂邾łD
@wIȈӖ͂͂肵ȂCphasiRNA5f[̔zɂ肪ȂƂ́CB튯ɂĔ邷ׂẴ^CvArgonautephasiRNA𗘗p邱Ƃ\ł邱ƂӖDA͋G߂C̕ϓɉĒn㕔̃Xe̔Cӂ̍זE㐶IɐB튯𕪉DAזE̍S\Ƃ֌WC΁głǂłhB튯𕪉鐫́CEq̂Ƃɂ͂ȂBlȂZƂDBւ̑]ƂĔJn鐶BphasiRNÁCBזEɂēٓIɔArgonautełȂCh{琶BɂĔArgonauteɂ荞܂CArgonaute̕WIƂȂRNAĂɕύXCłזE^̍זE􂩂猸ւƂӂނ悤ȑ̐ƂĂ̂ȂD
@}EX̐ɂ鐶BpiRNÂCpLepiRNAƂ΂錸זEɖLxpiRNÁCMYBt@~[̓]ʈqA-MybCpiRNȂORNApiRNA̎YoHɕKv<em>Tdrd6</em>`q<em>Miwi</em>`qȂǂ̓]ʂIɊ邱ƂɂC͂߂ċ@\邱Ƃm<a href="#R59"><sup>59)</sup></a>D̐}́CɏqׂCClɂbHLH^̓]ʈqEAT1ɂ24phasiRNA̎YoH̐<a href="#R18"><sup>18)</sup></a> AzDpLepiRNÁCA̐BphasiRNAƓlCIȔzWIƂȂRNA͖𖾂Cŋ߂̌CpLepiRNAq̌`̉ߒɂĕɗRݐmRNA𕪉\ȂǂĂ<a href="#R60"><sup>60)</sup></a>D
@}EXɂẮC~gRhÅԌɑ݂piP{fBj̋ߖTchromatoid{fBȂǂ̍זERNAphased piRNA̎Y̏ƂĒm<a href="#R61"><sup>61)</sup></a>DVEWEoGɂĂkA[WƂ΂ގ̍זERNȀdv񍐂Ȃ<a href="#R62"><sup>62)</sup></a>CɂĂpiRNA̎YɕK{̐BזEɂזEۑĂDCAɂĂ͖ĂȐBזEɂזE̕񍐂͂ȂDVCkiYiɂĂp4-siRNÃvZVO̒SjCajal{fBł邱<a href="#R63"><sup>63)</sup></a>CB튯ȊOŔphasiRNA̎Y̏̒iKE̖|\[Ɉˑ邱<a href="#R64"><sup>64)</sup></a>CȂǂm邪CBזEɓ@\ł͂ȂDAɖĂȐBזEɂזE܂ɂ݂ĂȂƂ́C̓IȐBlƍl킹ċ[D

<h2></h2>
@ǵCF̂𒒌^Ƃgɂ2{DNAؒfCɂNC̈ꕔ͑F̂̕IȌƂȂ抷ƂȂĎ݂ɉp̂G@łDŋ߂̌CAɂĂɂ2{DNAؒfя抷̕z͐F̂ɂĈlł͂ȂCDNA`qXgCȂǃN}`̏C\̈ႢCȂ킿CGsWFleBbNhXP[v傫e邱Ƃ炩ɂĂ<a href="#R65"><sup>65,66)</sup></a>DN}`fO^pNȂǂɂ킦C̃r[ɂďЉphasiRNAȂǐB튯ɂč鏬qRNÁC]ʗ}ČF̂̏IweN}`ȂǃGsWFleBbNhXP[v̌`ɈĂ\߂čDphasiRNAArgonautěɂp@̂ق̒mCɂđg̈ʒupx̕q`wIȑɂ앨̈ɉṕC܂łĂ̂ȂD

<h2> </h2>
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</ol>
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