]_oH̏Cɂ鑟̘Aւ̖

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i_E_oÌZ^[_o _o򗝌j
emailF<a href="mailto:muramtasu@ncnp.go.jp">ߎq</a>
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̈Zr[, <strong>8</strong>, e001 (2019)@<a href="http://dx.doi.org/10.7875/leading.author.8.e001">DOI: 10.7875/leading.author.8.e001</a>
Rieko Muramatsu: <strong>Systemic environments regulate central nervous system regeneration.</strong>

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<h2>v </h2>
@܂ŁC]_oH̏C@\̌́C]̓̍זE╪q̖ɒڂC̍p𖾂邩Ői߂ĂDCŋ߂̌ɂC]̊O̍זE╪q]_oH̏CɉeڂƂ킩ĂD̃r[ɂẮC]ȊȎ킩番傳zl̕ɂ͔]ҐɗƐ_oHC͂炫邱ƂoM҂̌܂߁C]_oH̏CɊւ邱܂ł̌̓D

<h2>͂߂</h2>
@_on̐_oHƔׂāĈ̔]̐_oH̏C͂ނD_oH̏C@\ɂ͓ъŐ@ƍlĂCȂ̂̔]̐_oHCɂ̂C]Ґ̍זEOɑ݂_oH̏CjQ镡̃^pN肳ꂽD̂悤ȃ^pNɑ΂j[̑̎êL[ƂȂזEVOi`BnɂĂ̌C_oH̏CjQ^pNWIƂ܂̊J̐ƂɂĐi߂C_oH̏C𑣂]_oɑ΂鎡Â̌ʂ؂Տɂ܂œBĂi<a href="#F1">}1</a>jD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@_oH̏C</strong>
iajȏԁD
ibjaԁDOǂɂ菝_oHC邱ƂɂCǂ̊ɘa҂D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2019/01/Muramatsu-8.e001-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2019/01/Muramatsu-8.e001-Fig.1.png&amp;caption=fig1-caption-text]

@ŁC̎ނl̂́ClדIȉȂĂ̂̔]̐_oHRɏC悤ώ@ꂽD̂ƂĈ̔]ɂ͐_oH̏C𑣂@Ɛ@C̋@ɂ́CƓlɁCWIƂȂj[̑̋@̂قCaԂɓIȐVǂ̊^CaɂČt]֖傪j]t邱Ƃɂ]̊Oɑ݂镪q]ɍp@̂邱Ƃ킩ĂD

<h2>1D_oH̏CjQ镪q@\</h2>
@]̐_oHCɂƂāCISfhTCgfЉ~G_oˋN̍ĐLjQ邱ƂƎwECMAGCNogoCOMgp3ނ̃^pNڂꂽD̃^pNɍ\Iȗގ͂ȂCCj[ɔNogoêƌDNogoêp75Lingo-1Ǝê̕`<a href="#R1"><sup>1)</sup></a>Cp75זEւ̃VOi̓`BSDp75̉̃VOi`BnɂĂ͕񍐂Ă邪C̐LjQɏdvȃVOi͒ᕪqG^pNłRho̊ƍlĂ<a href="#R2"><sup>2)</sup></a>DRhỏ̃^pNłRhoLi[[̑jQ܂RhoAs{ckXőfC3uƁC_oHC悤̎nɂĎĂ<a href="#R3"><sup>3)</sup></a>Cp75Rho_oH̏C̑jQSזEVOi`BñL[^pNłƔFĂi<a href="#F2">}2</a>jDłɁCRhoj[̑̎ê̕\^pNWIƂ܂JCҐ̑ɑ΂Տɂ܂œBĂ邱Ƃ<a href="#R4"><sup>4)</sup></a>C_oH̏C̑jQ@\WIƂ܂̊Jɒڂ܂Ă邱Ƃ킩D

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@_oH̏CjQ@\</strong>
iaj]Ґɑ݂ISfhTCg~G̒fЂ_oˋN̍ĐLjQD
ibjISfhTCg̑ɔ_oˋN̐LjQ^pŃCj[̑̎ê̕āCj[ɂRho邱Ƃɂ_oˋN̐LjQD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2019/01/Muramatsu-8.e001-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2019/01/Muramatsu-8.e001-Fig.2.png&amp;caption=fig2-caption-text]


<h2>2DɂĐ_oȞ`jQ^pN̊^</h2>
@MAGCNogoCOMgpɂ鎲̐LjQ͕̌O[vɂmFꂽC3̃^pNgvmbNAEg}EXɑ΂ĐҐ{Ă̍ĐL͊ώ@ȂƂ񍐂ꂽ<a href="#R5"><sup>5)</sup></a>DŁC~GɗR鎲̏CjQ^pNȊOɂڂ܂ĈȂŁCɂĐ_oȞ`ɂ邱Ƃ̒m^pN̋@\̉͂i߂ꂽDł́CЂƂ̗ƂāCRGMaƂ肠DRGMa͖ђʌ^̃^pNŁC̎WɂĎ̐Lɑ΂锽poĂ<a href="#R6"><sup>6)</sup></a>DҐ{bgɂĂ͊̃ISfhTCgj[RGMaĂCɂRGMa̔ʂ͍܂ĂDŁCRGMa̋@\jQ邱ƂړIƂāCҐbgRGMa̒aR̂𓊗^ƁCҐɂؒfꂽ玿ҐHCCɂ莸ꂽ^@\Pꂽ<a href="#R7"><sup>7)</sup></a>DRGMaƓlɐ_oȞ`ɂSema3AɊւĂC̓ٓIȑjQ܂𓊗^ꂽҐbgɂđODjҐHCCǏPƂʂꂽ<a href="#R8"><sup>8)</sup></a>D̕񍐂̂悤ɁCɂĐ_oȞ`𐧌䂷^pN_oH̏C̑jQ@\̗ɏdvłƔFĂD

<h2>3D̐L𑣐iזEɂ镪q@\</h2>
@CMAGNogoɊւ錤͐Vq@\TւƓWJDЂƂ́CNogoêɑ΂̃A^SjXgƂċ@\LOTUS̔ł<a href="#R9"><sup>9)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/3457" target="_blank">V_r[</a> łfځjDLOUTS͖^pNłCNogoêƃKhƂ̌܂͂炫邽߁CLOUTSߏɔƎ̏CiƍlꂽDۂɁCLOUTSߏɔ}EXɂāCҐ̂̂̑ODjҐH̏Cɂđiʂؖꂽ<a href="#R10"><sup>10)</sup></a>ĎʂCKh̋@\̔ɂė邽߂ɂ́C̋@\𐧌䂷镪q@\lKv̂邱ƂꂽD
@ЂƂ̕ƂāCj[̑̐Vê̓肪DPirB͖Ɖun̑̍זEɔMHCNXIq̔FɊ^邱ƂmĂC~GɗR鎲̏CjQ^pN̎êƂĂ@\邱Ƃꂽ<a href="#R11"><sup>11)</sup></a>DPirB<em>in vivo</em>ɂ@\ɂẮC̃mbNAEg}EXɂĎ_ȏ{fɂĕ]ꂽDC_o𑹏̃}EXɂĂPirBԂł̐Lʂ͔F߂ꂸCBDNF𓊗^Ď̐L\߂鏈u{ƂPirB̌ɂ鎲̏Cʂ̌oɕKvł<a href="#R12"><sup>12)</sup></a>ĎʂC̏CjQ^pN̋@\𐧌䂷邾ł͎̏\ȐLʂ͊҂łC̐L𑣂悤ȏu{ƂKvł邱ƂꂽD

<h2>4DזEO̊Ƃ̊֘A</h2>
@Ă͎RɏC邱Ƃ͂ȂƐMĂ̂̔]̐_oHł邪C]Ґ̂܂܂ȃxŐ_oHIɏC悤}EXT̉͂ɂĎĂD_oH̏CϋɓIɓ@ƂẮCɂ_oȞ`ɗގ@\CсCaԂɓIȊ̕ωɗR@\ǂ݂邱Ƃ킩ĂD
@ɂ莸ꂽ@\Ȃ߂̐_oH̏Cɂ͕݂̂邪<a href="#R13"><sup>13)</sup></a>ĈЂƂɁCɂזE܂ʂꂽj[̎V`ꂽ}C2j[ւƓ˂ĐVlbg[N`Ƃ݂D̎npāCɂĎ̐LʂF߂Ă^pN_oH̏Cɂ邱ƂؖꂽD}EX̑]玿fɂẮCƂ͔Ἁ玿ҐHҐɂĎ}`CҐ̉ݐj[ւƓ˂Dݐj[͐߂܂Ő_oˋNLC艺̃j[ւƓ˂邱ƂɂoCpXl̃lbg[N̍\zSD̂ȂŁCҐ̉ݐj[番傳BDNF玿ҐH̑TrkBêĎ̏CSƂ킩DҐ̑ɂBDNF̔}C̑ɂăVOi`BjQ肷邱Ƃɂ莲}̌`͑jQCԂ̌o߂ɂƂȂ_o@\̉񕜂}<a href="#R14"><sup>14)</sup></a>ĎʂCɂ_oȞ`̕q@\ɂ́CaԂɂ_oH̏CƋʂ@\邱ƂꂽD
@CaԂɓIȋ@ɂẮCɂĉȌǂ̐V_oH̏C㉟Ă邱Ƃ킩Dǂ̐V͑gD̎ɕKvƂ݂ȂĂD_oHƂ̊֘AɂẮĈɂČǂƐ_oiƂɁC_onj悤΂ΔF߂CǂɗRGhZ͔ɂ_oH̃KC_Xɂ邱ƂmĂ<a href="#R15"><sup>15)</sup></a>DM҂́CaԂɂ錌ǂƐ_o̊֘Aɂđdǂɗގ]Ґ}EXpĉ͂ƂC_oH̏CɂɂČǂV悤ώ@ꂽD܂Cł̕q@\́CǓזE傷vX^TCNj[̑̃vX^OWéiIPéjăj[ɂcAMP̍߂邱Ƃɂ_oH̏C𑣂Ƃ̂ł<a href="#R16"><sup>16)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/5919" target="_blank">V_r[</a> łfځjD̂̂CvX^TCNȊǑǂɗR^pN̐_oˋN̐LʂCvX^TCÑ~G̏CʂoꂽƂĈ̔]̐_oH̏Cɂ͌ǌn̕ωȂǕaɂIȊ̕ω^邱Ƃꂽi<a href="#F3">}3</a>jD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@å_oH̏C𑣐i@\</strong>
_oH̏CɂCȌǂ̐Vώ@DǓזE傷vX^TCNȂǂ̃^pNj[ɍpĐ_oˋN̐L𑣐iD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2019/01/Muramatsu-8.e001-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2019/01/Muramatsu-8.e001-Fig.3.png&amp;caption=fig3-caption-text]


<h2>5D]̊O̊ɂv</h2>
@܂ŏqׂ܂߁C]_oH̏Č͔̑]̓̍זE^pN̖𖾂邩Ői߂ĂC]̍lŎĂ^pNł͐_oH̎IȏCɂď\ɂ͗łȂDŁC]̂ق̋@\ɊւẮCbזELxɕ傳郌v`]̍זEւƍpĐېH𐧌䂷Ȃ<a href="#R17"><sup>17)</sup></a>C]̊O̊]̋@\𐧌䂷邱Ƃ󂯓ĂD܂CX̔]_oɂĂ͊ɂČt]֖傪j]悤ώ@CtɊ܂܂zȂǂ]ւƗ₷ƁC܂C]̊OŎYzɑ΂ê]̍זEɂĂ邱ƂȂǂCaԂɂĂ͔]̊O̊ɑ݂^pN]ւƗ_oH̏Cɉe\@ꂽD
@t]֖̔j]Ɛ_oH̏CƂ̊֘AɂẮCt]֖傪j]ʂɂĂ̓~G̏Cł邱ƂmĂ<a href="#R18"><sup>18)</sup></a>D~G̏C͔]̑gDזEłISfhTCgOזȆBJn邪C܂łɁCXCbזECSCؓזE傷^pNISfhTCgOזȆB𑣐i邱ƁC܂C̕q@\̈[ƂāCFGF21 <a href="#R19"><sup>19)</sup></a> ⃌v`<a href="#R20"><sup>20)</sup></a> ISfhTCgOזȆB𑣐i邱Ƃɂ~G̏C𑣂Ƃ킩ĂD̂悤ȃ^pN̓ɂ̓}EX̍זEx̃xł͎̉@pꂽCꕔ̃^pNɂĂ̓qg̔|{ISfhTCgOזEpBsCISfhTCgOזȆBi邱ƂmFꂽi<a href="#F4">}4</a>jDC̉ߒɂĂ͌t]֖傪nȂ߁CFGF21mbNAEg}EXɂĐȃ~Ǧ`sǂɂȂ邩ǂC]ɂ~Ǧ`͖쐶^̃}EXƍȂD́C~Ǧ`Ȏiojƌt]֖傪nȎiِjƂɎԓIȍ邽߂ƍl@ꂽD̂߁C̉ߒɂČtɊ܂܂^pN]ɉeꍇ́C̑Ώۂِ͑ɂȌۂɓ\@ꂽDɁCt]֖̃oA@\͋łł邪C̒ł͌ǂɂĂ̓oA@\ƎȂ̂D̂߁CtɊ܂܂^pN]ȊȎɂpāCƂ΁CgD̏C𑣐i\@邪C_ŁCɂĂ͂܂킩ĂȂDCM҂́CFGF21êVזEɂĂ肻̔𐧌䂷悤ώ@ĂĎʂ́CtɊ܂܂^pN]ȊȎ̏Cɂp\̂ŁCg̘AւՂƂgD̏ChƂV̌̔W҂D

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@]̊O̊_oH̏Cɍv</strong>
Ȕ]͌t]֖ɂO̊uĂDCaɂĂ͌t]֖傪j]Ă邱ƂCt]̓֓B₷ԂɂȂĂDtɂ͂܂܂ȃz܂܂ĂCSĝ܂܂ȑ킩番傳镪qǌnĔ]ɓBƁC_oHCp̂邱Ƃ킩ĂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2019/01/Muramatsu-8.e001-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2019/01/Muramatsu-8.e001-Fig.4.png&amp;caption=fig4-caption-text]


<h2></h2>
@_oH̏C̃RZvǵC]̔]̓ɑ݂^pN̖𖾂錤iK݂̔CaԂɓIȊ̒o⑟ԃlbg[ŇւƓWJĂDČ͔̈WrłCłɕ񍐂ꂽq@\ł͐_oH̏C̑Se𗝉ɂĂȂD܂C]̓ɂC̑jQɂĂӂуzbgȌΏۂɂȂĂĂCŋ߂ɂ́CyTCg̏CjQ邱Ƃ񍐂Ȃ<a href="#R21"><sup>21)</sup></a>CVזEԑݍp܂ɂ݂ĂDCɂ܂܂Ȋpx̌iނƂƂɁCoꂽ^pNɂ鎡Ẫ|eV؂邱ƂɂC_ǒǂɑ΂܂̊JiނƂ҂D

<h2> </h2>
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<li id="R6"><span class='au'>Monnier, P. P., Sierra, A., Macchi, P. et al.</span>: <span class="ti">RGM is a repulsive guidance molecule for retinal axons.</span> <span class='so'>Nature,19, 392-395 (2002)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/12353034" target="_blank">PubMed</a>]</span></li>
<li id="R7"><span class='au'>Hata, K., Fujitani, M., Yasuda, Y. et al.</span>: <span class="ti">RGMa inhibition promotes axonal growth and recovery after spinal cord injury.</span> <span class='so'>J. Cell Biol., 173, 47-58 (2006)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16585268" target="_blank">PubMed</a>]</span></li>
<li id="R8"><span class='au'>Kaneko, S., Iwanami, A., Nakamura, M. et al.</span>: <span class="ti">A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord.</span> <span class='so'>Nat. Med., 12, 1380-1389 (2006)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17099709" target="_blank">PubMed</a>]</span></li>
<li id="R9"><span class='au'>Sato, Y., Iketani, M., Kurihara, Y. et al.</span>: <span class="ti">Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation.</span> <span class='so'>Science, 333, 769-773 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21817055" target="_blank">PubMed</a>] [<a href="http://first.lifesciencedb.jp/archives/3457" target="_blank">V_r[</a>]</span></li>
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<li id="R12"><span class='au'>Fujita, Y., Endo, S., Takai, T. et al.</span>: <span class="ti">Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity.</span> <span class='so'>EMBO J., 30, 1389-1401 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21364532" target="_blank">PubMed</a>]</span></li>
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</ol>
<div class="au-profile">
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<span class="author"> ߎqiRieko Muramatsuj</span>
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