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iVw] VXe]aԊwj
emailF<a href="mailto:ms-ueno@bri.niigata-u.ac.jp">쏫I</a>
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̈Zr[, <strong>6</strong>, e003 (2017)@<a href="http://dx.doi.org/10.7875/leading.author.6.e003">DOI: 10.7875/leading.author.6.e003</a>
Masaki Ueno: <strong>Rewiring of neural circuits and functional recovery following brain and spinal cord injuries.</strong>

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<h2>v </h2>
@O⌌ǏQɂ]ҐQƁC_oH͔j]dĂȋ@\sSND̂͐_oHVɍČ\͂ɂƂڂ߁C]Ґ̏Qɑ΂{IȎÖ@͂Ȃ̂łDCߔŇɂCc_oHIł͂Ȃĕ҂NCQ̂̂ɋ@\ϗe邱Ƃ킩ĂD̃r[ɂẮC܂łɖ炩ɂĂ_oH̍ĕ҂̋@ɂāCނɂ錤𒆐SɉD_oH̍ĕ҂̉ߒ𗝉̎ƗʂƂ߂邱ƂɂC̋@\̉񕜂炷헪݂Ă̂ƍlD

<h2>͂߂</h2>
@]Ґ͊oCFmC^Ƃ@\ɂ̍sK肵C܂C_oɂ̓̊ێC܂ɒƂȂ튯łD]Ґɂ͖̐_oHIɂ͂߂炳Ă肻̋@\͂DǏQOƂvɂ]ҐQ\͐g߂Ȃ̂łC킪ł͔]ǏQɂ銳҂120lC]Ґ̊҂7lƂD̗vɂ肢ǐ_oHƋ@\sS▃ჂNЉɂȂ邽߁C_oH̋@\コ鎡Ö@̊JƂ߂ĂD@\̉񕜂ɂ͎ꂽ_oHČ邱ƂKvł邪Ĉ̔]͐_oHVɍ\z\͔͂ɂƂڂD܂ŁC_o̍Đ\㏸悤Ƃ鎎݂͑ȂĂC]ɂ_oH̕G䂦CČɗLȎ藧Ă͂܂mĂȂD
@ŁCꂽ_oH̋@\͏Q̂̂̒x̎R񕜂C邢͋tɁCƕϗe邱ƂÂmĂDߔN̖cȌʂC@\̕ω͏Q̂Ďc_oH̉YI㏞IȕωCȂ킿gĕҁhɂN邱Ƃ킩ĂD̂̔]ɂĂ_oHω邱ƂCcꂽ_oH𐶂Ö@J]݂ĂD̃r[ɂẮCQɂN_oH̍ĕ҂Ɋւb̎g݂т̐ʂɂĉCC@\̉񕜂݂т߂̓W]щۑɂĖ͍D

<h2>1D_oH̍ĕ҂Ƌ@\̉</h2>
@]ɉỸ|eV̂邱Ƃ͌ÂmĂCꂪ]ҐQꂽ̂̋@\̉񕜂̐_oՂƂĂƊώ@悤ɂȂ̂͋ߔNɂȂĂł낤DTɂA̎́Ĉ̂̐_oH̍ĕ҂̌ɒe݂邫̂ЂƂƂȂ<a href="#R1"><sup>1)</sup></a>i<a href="#F1">}1a</a>jD]玿1^ɂ͑̂̂ꂼ̕ʂ𓮂^̈悪D́C]玿̋ǏɓdChĂ̂̂̕ʂ̉^݂邱Ƃɂ킩DłƂ΁CwOrɑΉ̈ɔ][ǂNƁCxz̈̏ɂƂȂ^@\QD][ǂ̂̂Ɏwɉ^P{ƁC[Ǒ̎͂̎c̈ɂĎwOr̓ɂȂ̈悪g債CɂƂȂ@\񕜂<a href="#R1"><sup>1)</sup></a>Dc_oHYIɕωċ@\̉񕜂Ɋ^邱Ƃꂽ̂łDł́C̉ߒɂāC]ł͂NĂ̂ł낤D

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@_oH̍ĕ҂Ƌ@\̉</strong>
iaj]ɍ[ǂ̋N̂ɉ^P{ƎwёOrxz̈悪g傷Dc_oH̕ω^@\̉񕜂Ɋ^ƍlD
ibjQ̂̂ɋN_oH̍ĕҁDj[̎ˋNCVivX̐ڑC_o`BωD
icj̍ĕ҂̗lD傫āCĐiregenerationjCĐiregenerative sproutingjCisproutingj3ނD
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@ω̂ƂɂȂ̂͐_oH̐ڑ̍ĕ҂ƍlD܂ł̌ɂCj[̎ˋNCVivX̐ڑCɂ́C_o`B̕ωȂǁC܂܂ȃx̉YIȕω_oH̍ĕ҂ɂ邱Ƃ킩Ă<a href="#R2"><sup>2)</sup></a>i<a href="#F1">}1b</a>jDƂ΁C2qpč[ǂ̋ߖT̃j[ώ@ƁCˋN̓_Ci~bNɕωC[ǂ琔TԂ̂CVivX͂XpC̃^[I[o[傷Ƃ<a href="#R3"><sup>3)</sup></a>DזÊуXpC̍ĕ҂ɂ͐ڑ鑊肪KvȂƂC̑ɂωNƂC̕ω_oĤȂы@\̕ω炷ƍlDۂɁCĕ҂͑̌ɂĊώ@C`Ԃ̕ωƂȂƂ_Ci~bNȕωłƂD̃r[ɂẮCƂɎ𒆐SƂĐ_oH̍ĕ҂̉ߒɂďqׂD
@̍ĕ҂ɂ́C傫Ĉȉ3̎ނi<a href="#F1">}1c</a>jDǐؒfꂽ玲LgĐhiregenerationjCؒfꂽ̓rVȎ̑}gĐhiregenerative sproutingjCQĂȂVȑ}LghisproutingjCł<a href="#R4"><sup>4,5)</sup></a>D_onɂĎ̍ĐRɋN邱Ƃ͂قڂȂDł1Iȏ܂CXyC̐_oUwCajaĺC_o̍ĐɂĎƎvldˁC_onɂčĐ̐͌͊Ăƌ_Â<a href="#R6"><sup>6)</sup></a>Dł́Cؒfꂽ_o͍Đ邪Ґɂ͐NłȂƂώ@C_oɂ͎̐LɓKȂ̂邱Ƃ\D̂̂CߔNɂ܂ŁC܂܂ȂӂɂlדIɍĐȂĂC_oHČɂ͒LKvC܂āCĐ͋@\̉񕜂炷ɂ͓ՓxƍlĂDŁCɂẮCIɂ̎̈QƎ͂̎c甭肪N邱Ƃ񍐂ĂD܂CČ`ꂽ_oH͋@\ῶ̂邱Ƃ킩ĂĂDāC͐_oH̍ĕ҂ɂďdvȗvf̂ЂƂłƍlD
@ł͎ۂɁC͂ǂ̂悤ȏ󋵂ŋN̂낤DO]ǏQɂĂ͉^ǂ_oHы@\΂ΏQꐶɂ邱ƂɂȂĂD̗RC_oĕ҂̌̈ɂẮC^H̍ĕ҂Đ̋@悭TĂD^H͑]玿]Ƃʂ̒ƁC؂ւ̏o͌nɂȂ鉺ʂ̐ҐȂD̎w߂͎̉sHɂҐւƓ`BDȂłC]玿ƐҐƂю^Ik^ɏdvƂ玿ҐH́CqgɂĂ̏Q^sŜȗvɂȂ邱ƂL̑ΏۂɂȂĂi<a href="#F2">}2a</a>jD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@^H̍ĕ҂Ƌ@\̉</strong>
iaj^эIk^ɏdvȔ玿ҐHiނ̗jD]玿̑Vwɂj[͂ɔΑ̐ҐDւƎ𓊎˂DނɂẮCҐ݃j[C^j[Ƃ̐ڑ؉^𐧌䂷D
ibjQ̂̂ɋN玿ҐH̍ĕ҂̂܂܂ȃp^[Dɂ`ꂽ_oH@\̎R񕜂Ɋ^D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/06/Ueno-6.e003-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2017/06/Ueno-6.e003-Fig.2.png&amp;caption=fig2-caption-text]

@̔玿ҐH\j[⎲QƁCc_oHɂĕ҂邱Ƃ̌ɂĎĂD̏ꍇCɂ`ꂽ_oH@\̎Rȉ񕜂ɍv悤łDƂ΁CbgɂāCҐ̑̂̂c玿ҐHɂ㏞̐_oH`CIɐؒfƉ񕜂@\ӂђቺƂCVɌ`ꂽ_oH^@\̉񕜂Ɋ^邱Ƃ؂ꂽ<a href="#R7"><sup>7)</sup></a>i<a href="#F2">}2b</a>CjD܂CbgɂāCҐ̑ɂ玿ҐHؒfƎ̓r瑤}LC̏ʂƉʂƂтҐŗLj[ɐڑȂC̐ڑ͑Č㎈̋@\xz鍘ւ̃oCpX`㎈̋@\̉񕜂炷Ƃꂽ<a href="#R8"><sup>8)</sup></a>i<a href="#F2">}2b</a>CjD
@M҂̌O[v́C]fɂĔ玿ҐH̉YIȕωώ@<a href="#R9"><sup>9)</sup></a>i<a href="#F2">}2b</a>CEjD}EXɂĕБ̑]玿̉^L͂ɑƔ玿ҐHED玿ҐH͔̎]ɂČĐҐւƐL邽߁CƔΑ̑Ő@\QꂽDCTԂƉ^@\͏XɎR񕜂DƔΑ̎c玿ҐH𒲂ׂƂC򐑂ɂđ̔肪NĂD̎͐ĔΑւƐLĐҐ̃j[ƐڑCVɑ]玿ؓւƘAȂ_oH`ĂDۂɁC񑹏̑]玿̉^dChƖბ̑Ő؉^NC܂C̐_oHؒfƎR񕜂^@\ӂюꂽĎʂCc玿ҐHVȐ_oH`^@\̎R񕜂Ɋ^邱Ƃ킩D
@_oH̍ĕ҂́Cނ݂̂Ȃ炸Cqgɋ߂TɂĂɋN邱ƂĂDƂ΁C򐑔ؒffɂẮC̉ʂ̎c玿ҐHɂĔɂ莲̖x㏸CVivXʂ̑ȂǍ\IȕωNƂ<a href="#R10"><sup>10)</sup></a>D܂CUwIȕω͏㎈̋@\̉񕜂̒xƂ悭ւĂDނуTƔ肪ɍLۑꂽۂł邱ƂCۂɃqg̊҂ɂĂ͋N肤̂ł͂Ȃ낤D
@ɂĕ҂́C]ҐɂQ̏ꏊ傫ɂC玿ҐHɂƂǂ܂炸C玿ԗl̘Hԗl̐ҐH<a href="#R11"><sup>11)</sup></a>C玿ԊjH<a href="#R12"><sup>12)</sup></a> Ƃق̏㉺sHɂN邱Ƃ񍐂ĂD܂CQ̋ߖT̗̈ɂNDƂ΁C][ǂɂĂ͑]玿̉^⊴oȂǉ^@\ɏdvȔ]̖̂̐ڑQD]玿̋Ǐɍ[ǂNƑ]玿̃lbg[NɂĂ肪NC[Ǒ̎͂Ɏcj[ɂĐVȐڑ<a href="#R13"><sup>13)</sup></a>D悤Ȍl̕ώCT̑][ǃfɂĂF߂Ă<a href="#R14"><sup>14)</sup></a>D̕ωɂĕ҂C@\}bv̍ĕ<a href="#R1"><sup>1)</sup></a> ̈[ƂȂ邱ƂD
@܂C_oH̍ĕ҂͉^HɂƂǂ܂炸CoH<a href="#R15"><sup>15-17)</sup></a> ⎩_oH<a href="#R18"><sup>18)</sup></a> ɂNDƂ΁C_oHɂ͔]ȂǏʂ̒狹ւƂނsHC疖_oɂ肨̂̂̑ւƃVOi`BDҐɑNƉsHւ̓͂̎ՒfɂƂȂ_oɏQN邱ƂmĂDM҂́C̉ʂɎc_oHj[Ƃ̐ڑ𑝉ĕωCtɐ_oH邱Ƃo<a href="#R18"><sup>18)</sup></a>D_oH̍ĕ҂́CQ̂̂C]ҐɂĕՓIɋN錻ۂȂ̂łD

<h2>2D_oH̍ĕ҂̋@</h2>
@ĕ҂ꂽ_oH͋@\̉񕜂ɍvł邱Ƃ݂ĂC̍ĕ҂Ȃ@\͉ł낤D̋@킩΁C_oȞ`̉ߒ܂䂵ėLȎÖ@ւƌтłD
@_oḦꕔQƎ͂̎cVɐNƂۂ́C͌ÂmĂD1940Nɂ́CɂĔ畆ւƐLтĂ閖_oؒfƂق̗̈悩玲N邱ƂĂ<a href="#R19"><sup>19)</sup></a>D̕ώĈ̂CWZp̐iɂC_onɂĂXɑNɂȂD1958Nɂ́CWIƂ鎲ؒfϐFNauta@̓oɂClRɂāCҐւƐL鉺sH⊴o_oQԂƎco_o̐ۂVɐҐ֐N邱Ƃώ@ꂽ<a href="#R20"><sup>20)</sup></a>D1969Nɂ́Cbg̒ujɂāCCn邢͎Lт钆ujւ̓͂̂ꂩՒfƁC̎uj̃j[ƐVɃVivXɂ_oH`邱Ƃdqɂ莦ꂽ<a href="#R21"><sup>21)</sup></a>Dl1973Nɂ́CCnɂĚk玿̓͂ȂȂƁCAۂNĐVȐ_oH`邱ƂdCwIɎꂽ<a href="#R22"><sup>22)</sup></a>D𒆐SƂĕ҂ɂVɐ_oH`邱Ƃ炩ɂꂽ킯łD͂܂C`ꂽ_oHwIȋ@\ɂ܂ŏ؂邩ǂ͂悭킩ĂȂĈ̔]ɂďQ̂̂ɐ_oHω邱Ƃ̏dv͂łɔFĂ<a href="#R22"><sup>22,23)</sup></a>D
@̍ĕ҂N@ɂẮC͂܂Ă̑Se͖炩ɂĂȂD炭C_oHɂQƂȂCɔĎ͂̎LWIƂȂj[Ɛڑ̂ł낤D_oȞ`́CC┭B̒iKɂċN̂ł邩Cł̌ۂqgƂȂƍlĂD_oH̔B̉ߒɂẮC_oh{q⎲KC_XqɓĐ˂CɁCoɂƂÂ_oɈˑIȃVOiɂ_oHkD̂悤ȉߒ͏Q]ɂN̂낤D
@}Nڍׂȋ@\ɂĂ͂܂悭킩ĂȂCBɎ̗UCC}Nq͂mĂDQƂɂ́CƂ΁C̓͂j[ɂȂ炩̕ωCo邱qʂ̎U\li<a href="#F3">}3</a>CjDƂ΁Cĕ҂Ȃ^pN̒T̂߈`qXN[jO݂Ă<a href="#R24"><sup>24,25)</sup></a>ĎɂẮCsHQ̂ɐҐɂĐ_oh{q⎲KC_Xq̑F߂Ă邪C̍ĕ҂ȂӔC^pN̓ɂ܂ł͂ĂȂDM҂́C]fɂāC_oh{q⎲KC_XqԗIɃXN[jOʁCWIƂȂҐ̃j[ɂ͐_oh{qBDNFĂCQ̂̂̔玿ҐH̎̎}ɕKvł邱Ƃ𖾂炩ɂ<a href="#R9"><sup>9)</sup></a>Dꂾł͍ĕ҂̉ߒׂ̂Ă͐ȂCĕ҂̕q@\̒TɌĂƂD̂̂C̓͂Ґ̗̈ɂĉh{qCNTF̔㏸邱ƂoCꂪ̔ЂNƂꂽ<a href="#R26"><sup>26)</sup></a>D܂C]玿ɂĂ͍[ǂ̂̂ɐ_oh{q⎲KC_Xq̔㏸C[Ǖ̎͂̃j[GDF10ɂ莲̔肪Ȃ邱ƂoĂ<a href="#R13"><sup>13,27)</sup></a>D܂CÂC̓͂̈ɂăVivX̋ߖT̃AXgTCgɂ`ԓIȕω̋N邱ƂmĂ<a href="#R23"><sup>23)</sup></a>D̖ɂĂ͂悭킩ĂȂCߔNCAXgTCgog{X|W1уg{X|W2[ǂ̂̂̎̔肨уVivX̐Vɂ邱Ƃ񍐂Ă<a href="#R28"><sup>28)</sup></a>D

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@_oH̍ĕ҂̋@</strong>
WIƂȂj[̃VOiɂ鎲̍ĕҁijC邢́C̋p̉Ȃ̍ĕ҂iEjC_oɂ_oH͐kijD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/06/Ueno-6.e003-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2017/06/Ueno-6.e003-Fig.3.png&amp;caption=fig3-caption-text]

@ŏqׂ悤ȈqIɍĕ҂Ȃ̂C邢́CX̏Q̏󋵂ɂgqς̂́C܂̂Ƃ悭킩ĂȂDm̈q̒T܂߁Cĕ҂̕ՓIȋ@\̉𖾂҂ƂłD
@܂ŏqׂh{їUȊỎ\ƂāCǂ̋pƂɂ@l<a href="#R23"><sup>23)</sup></a>i<a href="#F3">}3</a>CEjD̋ṕCƂƐ_oH̔B̉ߒɂĂ݂̂łDWIƂȂ̈ɂċψɕz邽߁Cʌ̃j[Lǂ񂷂DQƎ̒Eɂ肱͉̋ČʁC󂢂Ԃɂق̎荞ނƂۂN\lD̐^U͂܂肩ł͂ȂC玿ҐHǂȂǓ̎̋łꍇ<a href="#R9"><sup>9)</sup></a>C玿ҐHƊo_oȂǕʎ̎ǂ̏ꍇ邩Ȃ<a href="#R20"><sup>20,29)</sup></a>DC̒ÊȂ̈ɂčĕ҂Np^[C̏ꍇCE̋@\͂ȂȂD
@ŌɁCB̉ߒɂẮC܂Ȑ_oH`ꂽ̂C_oɈˑIĐڑkD̉ߒɂẮCHebbɂo͑Ɠ͑̐_övڑcCKv̂ȂVivX͊荞܂DQ̂̂ɂ͎II邢̓_ɕWIƂȂ̈ւƓ荞ނC̍ĕ҂̉ߒɂĂCŏIIɂHebbɂގ̋@\ƕWIƂȂj[Ƃ̐ڑcƍli<a href="#F3">}3</a>CjDnre[Vɂ̋@\_oHDɂȂƂʂ݂ƁC_oɂڑ̋NĂłDM҂CUwIɁCQɂ玿ҐH̔肪îC荞݂ɂ莲邱Ƃo<a href="#R9"><sup>9)</sup></a>DwI邢͉UwIȕώC_oH̔B̉ߒČ邩̂悤łD

<h2>3D_oH̍ĕ҂Ȃɂ</h2>
@_oHĕ҂ł邱Ƃ͂킩Ă̂́C̕ω͔ɋN̂ł͂ȂCꂽ_oH₢̂ł͂ȂDł́Cĕ҂啝ɑ邱Ƃ͉\Ȃ̂낤D_oHČȂȗv́C܂Qɂ葽̃j[邱Ƃɂ邪Cc_oHLɎgƂꍇCCajal\悤ɁC_oɂĎeՂɐLłȂƂɂv낤DȗCȂ炭ÂĂ̌ʁĈ̔]ɂĎL邢͍ĐłȂv͊Oѓ2ɑʂĂD
@O̗vƂāCCĐɓKȂ_o̊ɂĂ̓j[̐𑣐iqsĂƍlꂽi<a href="#F4">}4</a>jDB̉ߒɂĖLxɑ݂_oh{q⎲KC_Xq́Ĉ̔]ɂĂ͈قȂ锭̗l蔭ʂĂ肷DہCQ̂̂ɐ_oh{qłNT-3BDNF킦Ǝ̐Li<a href="#R9"><sup>9,30)</sup></a>DāC_oh{q̓Y͍ĕ҂ȂLvȐ헪̂ЂƂȂDC_oh{qق̐_oHhĂ܂ُȐ_oH`댯D̏ꍇɂ͐ȋ@\܂邽߁CK؂Ȑ_oH̍ĕ҂Nɂ͐_oh{qɔ_oHِ̓ɂȂł낤DKC_Xq̂̔]ɂĂ͂͂┭BƓl݂̔͂ȂDĈɂĂĕ҂ꂽ͂܂Ă鎲KC_Xqɂ[gIł邱Ƃ<a href="#R31"><sup>31)</sup></a>C̗Ű@ƂĎg\͎cDɂĂCB̒iKɂ邱̈q̔ČĐ_oH̍ĕ҂i߂邱Ƃ͂ȂȂƂD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@̐LɓKȂ_o̊</strong>
̊Oѓ̗vWIɂ΁C̐Lѐ_oH̍ĕ҂𘴐i邱ƂłD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/06/Ueno-6.e003-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2017/06/Ueno-6.e003-Fig.4.png&amp;caption=fig4-caption-text]

@1980NɓƁCtɁĈ̒_oɂ͎̐LjQÖq݂̑邱Ƃ͂߂<a href="#R32"><sup>32)</sup></a>D܂ŁĈ悤ȊÖqƂă~Gɔ^pN݂Ăi<a href="#F4">}4</a>jD~G݂̑ɂ莲̐LjQ邱Ƃ炩ɂĂ<a href="#R33"><sup>33)</sup></a>C܂łɁC̐ӔC^pNłNogo⑽̊֘A^pN܂êoĂ<a href="#R5"><sup>5)</sup></a>D̃^pN͎̐~̕Ď̐L}ƂDۂɁC]ҐQꂽƂɂ̃^pNjQ邱ƂɂCĐi邩ǂ͂܂c_邪C͑i<a href="#R5"><sup>5,34,35)</sup></a>D̐LjQq̒T₻̃VOǐ͌ݐis`łÂĂDjQ@₻̗ʁCɂƂȂق̐_oHւ̕pȂǁClׂ_͑C܂̂ƂC_oH̍ĕ҂𘴐i邽߂ɔɊ҂WIłƂD
@ЂƂ̗̒vłi<a href="#F4">}4</a>jD]̔BɂďQɂꕔ̐_oHƁCc_oĤ̔]ɔב啝ȕωƂ͌ÂmĂDM҂C}EXɂĔ]̏QɂN玿ҐH̍ĕ҂͐14܂ł͑K͂ɋN邱Ƃ<a href="#R36"><sup>36)</sup></a>Dĕ҂̋K͂̕ώCЂƂɂ͔]̔B̓r猻~G͂߂Ƃ鎲̐LjQq̑CȂ킿CO̗vɂ̂ƂĂ邪CЂƂ́Cj[ꎩ̂̂̐L\̂ɂȂɂ邱Ƃɂ邱Ƃ킩ĂDꂪ̗vłDۂɁCԖ̃j[̂̐L\́CCIɒቺƂ<a href="#R37"><sup>37)</sup></a>Ď̒T͂܂i߂ĂƂ낾CƂ΁C]ʈqKLF4͍זEnɂĔ㏸Cꂪ̐L\̒ቺɊ֘AĂ<a href="#R38"><sup>38)</sup></a>D܂tɁCt@~[̓]ʈqKLF7͎Ⴂj[ɑ̂ɂĂ͌邪CҐ̑̂̂ɉߏɔƔ玿ҐH̍Đє肪i<a href="#R39"><sup>39)</sup></a>D̂قɂCcAMPZx<a href="#R40"><sup>40)</sup></a>CSox11 <a href="#R41"><sup>41)</sup></a>CSOCS3 <a href="#R26"><sup>26)</sup></a> Ƃݐ̗v̐L͂K肷Dv̂Ȃł炭ƂʂĂ̂PteñmbNAEgł낤<a href="#R42"><sup>42)</sup></a>Dj[̐nQNƍזE̐ɂȂmTOR̊ቺ邪CmTORjQzXt@^[[łPtenmbNAEgƂCmTORƂƂɖ|̘i͂߂ƂזEɂVOiC玿ҐH̍Đє肪ɑiꂽDj[邢͎̏̂Ȃ͐_ő@\ɕɂ͂炭\CVOi鎞ʂɂĐTdȌKvł͂邪C̃VOi̊ɂ헪̂ꂽ|eV݂łƂD
@ŌɁCj[_oHꎩ̂̐_oC_oȞ`Ȃ߂̏dvȗvłDB̉ߒɂāC_o͎̎}Ȃǂ̐Lѐ_oH̐k̗ɂ͂炭D́CQ̂̂ɂ݂CƂ΁C玿ҐHpIɓdChƔɂĕ҂@\̉񕜂ɂvƂ<a href="#R43"><sup>43,44)</sup></a>D̐_oǂ̂悤ȋ@ɂ莲̐L𑣐îC̏ڍׂ͂킩ĂȂC̃VOi̊ƍlĂCĕ҂𘴐i悢iƊ҂ĂDCׂ́CK؂Ȑ_oȞ`ɂ́CO̐lדIȎhɂCsɑ_o̎NKvł邱ƂłD_oɕKvƂ̕񍐂<a href="#R45"><sup>45)</sup></a>Cnre[VȂǁC莩RȐ_o̎NƂ̑gl˂΂ȂȂD

<h2>4Dĕ҂ɂK؂Ȑ_oH`ɂ</h2>
@_oH̍ĕ҂lדIɑ錤ʂCLɕWIƂȂK؂ȃj[Ɛڑ邩ۑƂĎcĂDQ̂̂C@\㏞IȍsւƕωC邢́CKvȋ@\tɑjQ⑝肷悤ȕsKimaladaptivejȕωƂĎۂɂĕ҂_oHeĂ\C̏ꍇɂ́C@\̔ɕsK؂Ȑڑ̌`ɂƍlDY͂ǂ̂悤ȕւ@\ϗe͂킯łD
@Ƃ΁CЂƂ̂^g[jOɂ_oH̍ĕ҂ȂƁCЂƂ̉^ɂ@\񕜂ƂĂCʂ̉^ɂ@\ُɂȂ邱Ƃ񍐂Ă<a href="#R46"><sup>46)</sup></a>DM҂Cnre[V̈Ⴂɂ_oH̍ĕ҂ւ̉eɂČC}EXɂāCGTƂPȃ[`ԂPƂ̓삵񕜂̌ʂȂ<a href="#R47"><sup>47)</sup></a>DtɁC葫IɓLPƍL͂ȉ^@\ւ̌ʂF߂C܂C玿ҐH̍ĕ҂ւ̌ʂDgsgp̊wKhilearned non-usejƂ錻ۂɊ֘AƎvCgpȂƐ_oH͋@\ȂւƎĂ܂DT̊bmꂽCIiconstraint inducedjÖ@͂̓_[<a href="#R48"><sup>48)</sup></a>CȑSჂ̑̎IɎgpƉ^@\̉񕜂ƂDہCނɂēlCIÖ@{ƁC@\̉񕜂ɂƂȂ玿ҐH玿ԊjH̍ĕ҂iƕ񍐂Ă<a href="#R12"><sup>12,25)</sup></a>D́Cnre[V̌ʂ̐_oՂ̈[̂ł邪CɁCƂ߂@\ɂK؂Ȑ_oH`悤PȂ΂ȂȂƂÎĂD
@K؂Ȏhŉ邱Ƃɂ_oH܂`ł΂CƂƐ_oHɓ݂@\͂炢Ă܂ƁC@\̉񕜂ɂ悤ɂ܂ĕ҂i܂ȂꍇDƂ΁C玿ҐHQɂEƁCEҐ̗̈ɖ̌ŗLoۂNĂ܂ČʁCؔ˂iĂ܂<a href="#R29"><sup>29)</sup></a>D̗\Ȃĕ҂؂ْ̋izkispasticityj̗v̂ЂƂɂȂƂ݂DقɂCĕ҂_oHُȐڑ`ꍇCɂ݂}Ȍ̏㏸ЂN_oߔ˂ɂ邱ƂwEĂ<a href="#R18"><sup>18,49)</sup></a>D܂ClדIɉߏȍĕ҂NƂꍇɂӂKvłDƂ΁CPteñmbNAEgɂ莲̐L傫Ă@\̉񕜂͌ɂ͋NȂ<a href="#R50"><sup>50)</sup></a>DSox11̉ߏȔɂ玿ҐH̍Đє͑邪CIk^̋@\͂ނ눫<a href="#R41"><sup>41)</sup></a>DҐ𑹏̂_oh{qBDNF𑹏т̋ߖTɔƖԗl̐ҐH̎̐L邪CtɁC^@\͒ቺzkĂ܂<a href="#R51"><sup>51)</sup></a>D
@݂ƁC@\̉񕜂炷ɂ͓K؂ȗʂѓK؂Ȑڑɂĕ҂Kvł邱Ƃ킩DߔNC̓_ɂĉIȐʂ񍐂Ă<a href="#R52"><sup>52)</sup></a>D][ǂ̂̂΂炭RNogo-AR̂̓^ɂ莲̐L𑝉鎞ݒ肵ĈɁCnre[V{ƂÃvgR[ʁCҐɂ玿ҐH̍ĕ҂iCƂƂɋ@\̉񕜂̌ʂ܂DtɁCRNogo-AR̂̓^ƃnre[V𓯎ɍsƋ@\ւ̌ʂ͑łꂽD̏ꍇɂ玿ҐH̍ĕ҂͘iCُɉߏɐN鑜ώ@ُȐ_oH`ꂽƐ@ꂽD]̔B̉ߒɂẮCŏɎ̐LNĈ̂C_oɂ_oHkD̐_oH̔B͂ĕ҂ЂN헪ƂāČ͋[ʂ񎦂ĂDK؂Ȏїʂĉ_oH̐ڑȂ˂΂ȂȂ̂łD

<h2></h2>
@_oH̍ĕ҂̌ɂ傫ȃS[́Cɐ_oH̍ĕ҂𐧌䂵ʓIɋ@\Čł邩C̎@oƂɂD̂߂ɂ́C_oH̍ĕ҂̋@͉Cǂ̂悤ȕ@ĕ҂𑝉邩Cĕ҂_oH͂ǂ̂悤ɋ@\邩CƂ{Iȉۑnɉ𖾂邱ƂKvłDƂɁCĕ҂ꂽ_oHƔꂽ@\Ƃǂ̂悤Ɍт̂؂邱ƂCZpIȖʂ܂߁Cꂩ̑傫ȉۑ̂ЂƂƂD܂ł̌ɂCˋNCXpCČ`ԓIȕω␶wIȔ̕ω炩ɂC_oHĕ҂̂тĂ邪C_oHɂ錻ۂǂ̂悤ɂċ@\ƌт̂C̗l⓮쌴̖ʂ痝邱ƂKvƂȂĂD
@]̋@\̗́CCȔ]ɂĂ܂܂𖾂̗]n傫DȐ_oHǂ̂悤Ȑڑċ@\̂C_oHǂ̂悤ȋ@ɂ`̂ɂĂ킩ĂȂƂDȂCߔN̐_oȊw̋Zp̐i͂߂܂DȔ]̃RlNg[͂т̐_oHDȂ@\̉͂͂ܗ߂Ă邪C̒mƂɂ΁CQ]̐_oH͌ȏԂǂ̂悤ɕωċ@\Ă̂NɂȂ邾낤DZp͐Ȕ]₻̔Bɂ͂ɗpĂCQ]̐_oH̉͂ɂXɎg͂߂ĂD`qϋZp<a href="#R53"><sup>53-55)</sup></a>C`wщw`wIȎ@<a href="#R18"><sup>18,26,52,55-57)</sup></a>CECXg[T[<a href="#R12"><sup>12,18,26,52,53)</sup></a>CC[WOZp<a href="#R3"><sup>3,17)</sup></a> ɂC̃j[_oHWIɂώ@@\̏C\ɂȂĂDɂCǂ̂悤Ȑ_oH@\̉񕜂邢͑Ɍт̂݂͂߂ĂD܂Cq@݂ƁCĕ҂ꂽ_oȞ`̋@\m邱Ƃ̉ۑ̂ЂƂł낤DRNA-seq@͂߂ƂK͂Ȉ`q͂̋Zpɍv邩ȂD
@ރf́CŐ[̋ZpgēٓIȐ_oHɃANZX₷ƂCꂩLpł낤DŁCb̐ʂՏpւƂȂ͂ق̂ЂƂɂłCqgƂ̃VXëႢʂ̈Ⴂ𐶂ݏo\\ɍl˂΂ȂȂD퍷OɓȂC_oĤ{Iȋ@\T邱ƂKv낤D̃r[ɂẮCނ𒆐SƂbɂďЉCɏqׂZp̓Tɂ鉞p݂ĂC܂܂Ȑ񂪎菜΃qgɋ߂fɂ錤iƐił낤D]̐_oH͂ŉ񕜂邵݂m肻⏕@m邱ƂC]_o̎Ö@̊J⃊nre[V̉ȊwIȊՂ̍\zɍv̂Ɗ҂D

<h2> </h2>
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</ol>
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