]V玿ł̐_oȞ`ɂ鎲KC_X@\

<strong>VmEcp</strong>
iF{ww@Ȋw _owj
emailF<a href="mailto:shinmyo@kumamoto-u.ac.jp">Vm</a>
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̈Zr[, <strong>3</strong>, e002 (2014)@<a href="http://dx.doi.org/10.7875/leading.author.3.e002">DOI: 10.7875/leading.author.3.e002</a>
Yohei Shinmyo & Hideaki Tanaka: <strong>Axon guidance mechanisms in forebrain connections.</strong>

<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/02/Tanaka-3.e002-PDF.pdf" target="_blank"><img class="size-full wp-image-112 alignright" title="Download PDF" src="/images/downloadPDF.png" alt="Download PDF" width="100" height="20" /></a>
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<h2>v </h2>
@]ɂĂ͖cȐ̃j[IȐ_oHlbg[N`ĂD_oHǂ̂悤ɂČ`̂𗝉邱Ƃ͔]̋@\𗝉邽߂ɏdvł݂̂Ȃ炸C̐_oɑ΂ĐÂ邽߂ɂKvsłD20NԁCNetrin͂߂Ƃ鎲KC_X^pNƂ̎ê肳ꂽƂɂCKC_X̊ՂƂȂ镪q@\𖾂ꂽDɁC`qσ}EXp̃xł̈`q̋@\͂C]ł̐_oȞ`ɂ鎲KC_X^pN̖炩ɂĂDł́CKC_X@\ɒڂC}EX̑]V玿ɂvȐ_oHǂ̂悤Ȃ݂ɂ`̂D

<h2>͂߂</h2>
@]V玿͎vlȂǂ܂܂ȍ̔]@\ǂ튯łCqgł͒]Ԕ]قǂ̑傫߂D]V玿ł͓IȍזEwώ@Cw\ɂƂÂ_oHlbg[N`Ăi<a href="#F1">}1</a>jD̐_oH͔ɕGł邪CقǐIŔ\<a href="#R1"><sup>1,2)</sup></a>DƂ΁C2/3w̃j[͓̎邢͔Α̑]玿i]j֓˂C4w͎玿̎˂͑włD5wɂ́C]`j[ƁCoRďuCCҐȂǉ̗̈֓˂j[݂D6wуTuv[gj[͎̎֓˂Dł́C̑lȐ_oHǂ̂悤Ȃ݂ɂ`̂ɂāCKC_X^pN̖ɏœ_Ăĉ<a href="#R3"><sup>3)</sup></a>D

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@}EX̑]V玿ɂvȐ_oH</strong>
iaj]V玿ɂ鎲̓ːD
ibj]V玿ɂj[̑w\Ǝ̓ːƂ̊֌WD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/02/Tanaka-3.e002-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2014/02/Tanaka-3.e002-Fig.1.png&amp;caption=fig1-caption-text]


<h2> 1DKC_X^pN</h2>
@mȐ_oHlbg[Ň`ɂ́CɎWĨj[ɂނĐLVivX`KvD̎KC_Xɂ^pNKC_X^pNƂԁDKC_X^pN̂Ȃɂ́CזE̊Oɕ傳ĊgUz`鉓쓮̂̂ƁC傳ꂸɍזE̕\ʂɂĂ͂炭Z쓮̂̂Ƃ݂<a href="#R4"><sup>4)</sup></a>i<a href="#F2">}2</a>jD҂ƂɁCU邢͔KC_X^pNDł́CKC_X^pNƂāCNetrinCSemaphorinCSlitCEphrinɂďЉD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@KC_X̊{Iȕq@\</strong>
̐iH́CU邢͔KC_X^pN̂͂炫ɂ茈肳D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/02/Tanaka-3.e002-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2014/02/Tanaka-3.e002-Fig.2.png&amp;caption=fig2-caption-text]

@WĨj[܂ł݂тȖ݂́CXyC̉UwCajalɂ1Iȏ܂ĂĂĈ悤ȕۂɑ݂邩ǂ͒炭słD1980NɂȂC_o|{nɂē̎Uq݂̑Ĉ̂Cjg̔]番^ŗUKC_X^pNƂNetrin肳ꂽ<a href="#R5"><sup>5)</sup></a>DNetrin͖80 kDã^pNŁCזEO^pNł郉~j̃ƑDNetrin̎êƂẮCqg̑咰ɂᇗ}^pNłDCCCсC̕ψّ̂瓯肳ꂽUNC5悭mĂ<a href="#R6"><sup>6,7)</sup></a>D~̔͂2̎ê̔p^[ɈˑCDCĈ݂ł͗UCDCCUNC5זEɂăweʑ̂`Ɣ<a href="#R8"><sup>8)</sup></a>D
@傫ȃt@~[`鎲KC_X^pNƂSemaphoriniSemajDSemaphorin̓jǧ㍪_oߍזE̐~ޏk^pNƂē肳ꂽ<a href="#R9"><sup>9)</sup></a>D̂̂C20ވȏSemaphorin肳C\ɂ7̃NXɕނĂ<a href="#R10"><sup>10)</sup></a>DׂĂSemaphorinN[ɖ500A~m_cȂSemahCƂ΂IȔzCȊÕhC͑lĂC^Cђʌ^CGPI^ȂǁC܂܂ȃ^Cv݂DSemaphorin͎̔LjQ^pNƂčLFmĂ邪C̗Uɋ@\ꍇ<a href="#R11"><sup>11)</sup></a>DSemaphorin̎êƂĂNeuropilinPlexin肳Ă<a href="#R12"><sup>12)</sup></a>D
@]ҐȂǂ܂܂Ȏɑ΂KC_X^pNƂSlit<a href="#R13"><sup>13)</sup></a>DSlit͖1500A~m_cȂ镪^^pNłCCVb`s[gzCEGFs[gzCALPSiAgrin-Laminin-Perlecan-Slit spacerjzDSlit͂̎êłRoboăVOi`B邪CҒœɂĂSlitRoboɂ͂Ƃ3̑`q݂D
@Ephrin̓jg̖̊Ԗ]1oł鎋Wi}EXł́Cuɑjւ̓˂ɂĂ悭Ă鎲KC_X^pNł<a href="#R14"><sup>14)</sup></a>DEphrinɂGPI^іђʌ^CꂼEphrinAEphrinBƋ敪ĂDEphrin̎êłEph͍זEɃ`VLi[[hCCêƂِ̓ɂƂÂEphAEphBɕDɁCEphEphrinɂÕVOi`Bn̂قCEphAKhCEphrinAêƂċ@\t̃VOi`Bn݂C̑õVOi`Bɂ莲ˋ@\͍xGɐ䂳Ă<a href="#R15"><sup>15)</sup></a>D
@āCM҂́CVK̎KC_X^pN𓯒肷邽߁C^pN╪^pNcDNAIIɃN[jOVOiV[NGXgbv@pĕqXN[jOsĎʁCm̎KC_X^pNƂ͂܂̂ȂVK̕^̎KC_X^pNoCDraxiniDorsal repulsive axon guidance proteinjƖ<a href="#R16"><sup>16)</sup></a>D<em>Draxin</em>`q̓jg邢̓}EXɂĔ]Ґɂ钆_on̔wɔC]Ґ̌Aj[̎ɑ΂ĂDƂ΁Cjg̐ҐɃGNg|[V@ɂDraxinߏɔƁCҐ̌Aj[̎̐jQꂽDɁCDraxinmbNAEg}EXł͑]ׂ̂Ă̌Aj[i]CCnACOAjɂĎ̊SȌώ@ꂽD̐_oḦُ́C܂łɏqׂKC_X^pNɂψك}EX̕\^ƔׂĂdĂłƂCDraxin͔]ɂ_oȞ`ɂĂ߂ďdvȎKC_X^pNłƍlꂽD
@Draxin̎ê𓯒肷邽߁Cm̎KC_X^pN̎ê̂mbNAEg}EX̕\^ގ̂ɂāCƉu~@ɂDraxinƂ̌𒲂ׂĎʁCDraxinSlit̎êłRobo1Semaphorin̎êłNeuropilin1Ƃ͌ȂCNetrin̎êłDCCƓٓIɌ邱Ƃ킩<a href="#R17"><sup>17)</sup></a>DDCCmbNAEg}EXłDraxinmbNAEg}EXƓlɑ]ׂ̂Ă̌Aj[̌`sS񍐂ĂC̎˂ɂDCCDraxin̎êƂċ@\Ă\ꂽD҂̊֌W<em>in vivo</em>ɂĒׂ邽߁CDraxinDCCƂ̃_uփembNAEg}EX̌Aj[͂Dꂼ̒PƂ̃wembNAEg}EXł͔]̊SȌ͂قڊώ@ȂC_uփembNAEg}EXɂĂ͔]̊SȌpxɊώ@CDraxinDCCƂ̂̈`IȑݍpꂽDɁCDCCmbNAEg}EXɗR]V玿̑gDЁi]̃j[܂ށjł́C쐶^}EXɗRj[pꍇɔׁCDraxinɂ_oˋN̐LjQጸĎʂCDraxinmbNAEg}EXɂ]̌`ُDCCDraxin̔̌ɂNƍlꂽDŁCDraxinDCCłȂCNetrin̎êƂĒmĂUNC5CNeogeninCDscamƂDCDraxin̎êƂǂ̂悤ɑݍpVOi`Bn\Ă̂𗝉KvD

<h2> 2D]̌`@\</h2>
@]͍Ȇ]ȂAۂ̑łDM̔]ɂĔ]͂Ƃ傫Ȑ_oŁCȆ]V玿̂̏Ƃ肷dvȌoHƂȂĂD}EX̔]̏ꍇC80̃j[͑2/3w̃j[琶C20̃j[͑5w̃j[琶D
@]ɂ鎲̒ʘH̑Iɂ͂6ӏ̌|Cg<a href="#R18"><sup>18)</sup></a>i<a href="#F3">}3</a>jDŏC]̕\ʂ̕Ӊт番傳锽KC_X^pNSemaphorin3Â͂炫ɂC]͕̎̒ԑтɂނĐL<a href="#R19"><sup>19)</sup></a>i|Cg1jDɁCSemaphorin3A͓OɂZxz`ĂiŒႭCOŋjC]̎ԑтɂĐ̑ɂނ悤䂷<a href="#R20"><sup>20)</sup></a>i|Cg2jD̂̂C]̎͐ɑ݂glial wedgeCindusium griseumCsubcallosal slingƂזÊ͂炫ɂ萳<a href="#R21"><sup>21)</sup></a>i|Cg3jDglial wedge͍EΏ̂ɑ݂OAזEłCKC_X^pNłSlit2CDraxinCWnt5a𔭌Ă<a href="#R21"><sup>21)</sup></a>DSlit2Draxin͐܂̔]̎ɑ΂C̐̌ɂĕK{ł<a href="#R16"><sup>16,22)</sup></a>i|Cg3jDCWnt5a͐̂̔]̎ɑ΂CΑ̑]V玿ɂނĐLߒɂďdvłƍlĂ<a href="#R23"><sup>23)</sup></a>i|Cg4jDindusium griseum͔]ɂĎ̔wɂOAזEŁCKC_X^pNłSlit2Draxin𔭌邱Ƃɂw̏ǂƂĂ͂炭D܂Cj[łsubcallosal slingSemaphorin3C𔭌C̎êłNeuropilin1𔭌я玿̎U<a href="#R24"><sup>24)</sup></a>DdvȂƂɁCя玿͔̎]̎ɐCpCIjAƂĔ]̎̐̌ɂ<a href="#R25"><sup>25)</sup></a>Dŋ߁C̕t߂ɔNetrin1̋@\ɂ[񍐂<a href="#R26"><sup>26)</sup></a>DNetrin1͑я玿̎ɑ΂Ă͗UC]̎ɑ΂Ă͔ȂDɂ킦C]̎ɂނĐLł悤Netrin1Slit2̔}DEphrin-EphVOi]ɂ鎲˂ɂD]̎Ɛ̕t߂̃OAזEƂ̂EphBEphrinBƂ̑ݍpC]̎̂ɏdvł<a href="#R27"><sup>27)</sup></a>DɁCEphrinA-EphAVOi]̎̂̑ݍpĂ̎˂ɂ<a href="#R28"><sup>28,29)</sup></a>D]V玿̓琶鎲͔]̔wC]V玿̊OɗR鎲͕𑖍sCEphA3̎̕𐧌䂷邱ƂĂD̂ق[񍐂ƂāC番傳BMP7]ɂ鎲˂ɂ邱ƂĂ<a href="#R30"><sup>30)</sup></a>D]̎͑]V玿ɐNi|Cg5jCŏIIɂ͐_oɈˑIȋ@\ɂ萳WIj[֓˂i|Cg6jD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@]̌`@\</strong>
iaj]ƃpCIjAłя玿̎̓ˌoHD]̃j[̎˂ɂ́C6ӏ̌_D
ibj]̎̐̌ɂ鎲KC_X^pNƂ̎éD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/02/Tanaka-3.e002-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2014/02/Tanaka-3.e002-Fig.3.png&amp;caption=fig3-caption-text]


<h2> 3D玿ҐȞ`@\</h2>
@玿ҐH͑]V玿Ґɂđs鎲ŁCɔ玿^̑5w̃j[ɔi<a href="#F4">}4</a>jD玿^삩琶玿ҐH͓̎sC]C]ʉ߂̂CɂĂقƂǂ̎i80`85jΑɌ̌`DŏIIɁC玿ҐH̎͐ҐD̃j[ɓ˂D

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@玿ҐȞ`@\</strong>
玿ҐH̎˂ɂ鎲KC_X^pNƂ̎éD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/02/Tanaka-3.e002-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2014/02/Tanaka-3.e002-Fig.4.png&amp;caption=fig4-caption-text]

@ŏC玿ҐH̎͗UKC_X^pNSemaphorin3CƔKC_X^pNSemaphorin3Â͂炫ɂ玿璆ԑтɂނĐL<a href="#R31"><sup>31)</sup></a>DɁCj番傳UKC_X^pNNetrin1̂͂炫ɂ֗U<a href="#R32"><sup>32,33)</sup></a>Ĉ̂C玿̎Ƃ͕Ē]̑]rɓD玿Ґ̃j[ɔRobo1Robo2Ƃ̃_umbNAEg}EXł͔玿ҐHُ̎͐Ɍ邱ƂCKC_X^pNSlit1Slit2C̎êłRobo1Robo2Đ̑ւނȂ悤䂵Ăƍl<a href="#R34"><sup>34)</sup></a>D]ɐN玿ҐH͉̎̑ɂĐ邪C̉ߒɂ́CKC_X^pNłNetrin1Semaphorin6ACזEڒqłNCAML1ȂǁC̃^pN֗^Ă<a href="#R35"><sup>35-38)</sup></a>DƂ΁CSemaphorin6A̔CNCAML1ɂ鎲̂̑ݍp玿ҐH̎̂ɏdvłD̂قCEphrin-EphVOi͔玿ҐH̎̍Čɂ鍶E̐_oH̍h悤ɋ@\D܂C玿ҐH̎ɔEphA4ƁC̕ɔEphrinB3Ƃ̔̑ݍpɂC玿ҐH̎ӂѐȂ悤ɐ䂳ĂD[ƂɁCEphrin-EphVOiɊ֘A^pN̕ψك}EX́CETM̂悤ɍE̋r낦Ă͂˂Dl̕\^ψك}EX̌n̊mƁCɂÂ|WViN[jOɂCLɕψق肳ꂽ<a href="#R39"><sup>39)</sup></a>DɁCwIȎ@܂ޏڍׂȉ͂ɂCLEphrin-EphVOỉɂĔ玿ҐH̎̐L𑣐iRaĉ͂炫}邱Ƃ炩ɂꂽD
@玿ҐH̎́CӉ^_ȍQЂN؈ޏkdǂҐ̑ɂ^@\̏QȂǂɒ邽߁C̔Đ̌͗ՏIɂdvłDqgȂǂ̗쒷ނł͒_o̎̍Đ\͂Ⴂ߁CҐ̑ɂ^@\̒EǏ󂪐ƐUɂ킽ǂcD̗v̂ЂƂƂāC_onɂ͑̂̂̍ĐjQ^pNƍlĂDۂɁC̎ӂɂ͎L̑jQ^pNłNogoCKC_X^pNłSemaphorin3A<a href="#R40"><sup>40)</sup></a>D܂CGPIAJ[^pNłRGM̔Ґ̑ʂɂď㏸邱Ƃo<a href="#R41"><sup>41,42)</sup></a>CɁCbg̐Ґ𑹏̂RGM̌ʂ𒆘aR̂𓊗^邱ƂɂC玿ҐH̎̍ĐƉ^@\̉PɐD̂悤Ȏ̍ĐjQ^pNWIƂÖ@̊JɂCIɂ͋@\IȒ_o̍Đ݂тƂ\ɂȂƊ҂D

<h2> 4D玿ɂ鎲ˋ@\</h2>
@MɂāC͚kôق̂銴oi̐oCɊoCoCoCoȂǁj]V玿ւƓ`B钆pnłDꂼ̊o͎jɔ鎋玿̎ɂ]V玿̓ٓIȗ̈ɓ`B<a href="#R43"><sup>43)</sup></a>D玿͎̎ɂނĐLJnĈ̂CɂނĂ̕ςDSlit1Slit2Ƃ̃_umbNAEg}EX̉͂Cѐɔ鎲KC_X^pNSlit̔̎KC_Xɏdvł邱ƂĂ<a href="#R44"><sup>44)</sup></a>i<a href="#F5">}5a</a>jDƂ͑ΏƓIɁCI]͎玿̎ɑ΂UpDƂɁCCorridorזEƖÂꂽj[玿̎̑sɏdvł<a href="#R45"><sup>45)</sup></a>DCorridorזE͊OjɔC玿̎ɑ΂UKC_X^pNNeuregulin1𔭌i<a href="#F5">}5a</a>jD

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@玿̎˂̋@\</strong>
iaj玿̎˂ɂ鎲KC_X^pNDCorridorזEɂ͗UKC_X^pNNeuregulin1D
ibj玿̎̃g|OtBbNȓ˂ɂ鎲KC_X^pNƂ̎éDKC_X^pNEphrinA5Netrin1͕̔I]ɂĔ΂̔ZxzD
icjnhVFCNfD玿s̎Ǝ玿̎Ƃ̂̑ݍp݂̎˂ɕK{łƂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/02/Tanaka-3.e002-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2014/02/Tanaka-3.e002-Fig.5.png&amp;caption=fig5-caption-text]

@̂悤ɁCI]͎玿̎̒ԕWIʂƂďdvł邪CɁC玿̎̃g|OtBbNȓ˂ŏɐ䂷̈łDg|OtBNȓ˂Ƃ́C̈̃j[݂̑ΓIȈʒuێԂ̂܂ܕWIƂȂ̈̃j[ɃVivX`邱ƂłD玿̎̏ꍇCO㎲ɂg|OtBNȓ˃p^[ώ@<a href="#R46"><sup>46)</sup></a>DƂ΁COj甭鎲͑O玿ɓ˂COGj甭鎲1oɓ˂i<a href="#F5">}5b</a>jD܂C̑O琶鎲͑]V玿̑Ö̗ɁČ㕔琶鎲͑]V玿̗̌̈ɓ˂Ƃg|OtBbNȓ˂݂DŏCI]ɔ]ʈqEbf1Dlx1CDlx2̕ψك}EX̉͂C]V玿ɐN܂̕I]ɂĎ玿̎̃g|OtBbNȓ˂䂳Ă邱Ƃꂽ<a href="#R47"><sup>47)</sup></a>D̐NCEphrinA-EphAVOỉߒɂ邱Ƃ炩ɂꂽ<a href="#R48"><sup>48)</sup></a>DEphrinA5̎êłEphA3CEphA4CEphA7̔́CwɂđOō㕔ŒႢZxzi<a href="#F5">}5b</a>jD̔ZxźCI]ɂČ㕔ōOŒႢEphrinA5̔ZxzƂ͑Iłi<a href="#F5">}5b</a>jDɁC<em>in vitro</em>ɂEphrinA5͔ƂCEphA鎋̑O̎́CEphrinA5镠I]̌㕔̗̈悤˂ƍlDۂɁCEphrinA5EphA4Ƃ̃_umbNAEg}EXł́C̑O̎˂͕I]ɂČւƃVtgD
@KC_X^pNNetrin1I]ɂđOō㕔ŒႢZxz<a href="#R49"><sup>49)</sup></a>i<a href="#F5">}5b</a>jDNetrin1͎̑Oɔ鎲ɑ΂Ă͗UČ㕔ɔ鎲ɑ΂Ă͔D̔̈Ⴂ́Cɏqׂê̔̍قɂ萶DwɂDCC͑Oɍ㕔ɒႢZxzƂC̑Oɔ鎲ɑ΂UNetrin1-DCCVOidvłƍlDCUnc5ACUnc5BCUnc5Č͎㕔ɋ邱ƂCNetrin1-DCC//-Unc5VOǐ㕔ɔ鎲ɑ΂锽𐧌䂵ĂƍlD̂قCKC_X^pNSlit1I]ɂNetrin1Ɠl̔ZxzC玿̎̃g|OtBbNȓ˂ɂ邱ƂĂ<a href="#R50"><sup>50)</sup></a>D
@I]ɂĕꂽ玿̎́CŏIIɂ͑]V玿ɂēٓIȗ̈ɓ˂悤䂳Dbgَ̑e16ڂ̑]V玿̑Ö̗õbg̑]V玿̌㕔̗̈ɈڐAƁCOjѓj̎ȕWIłÔ݂Ȃ炸CڐAꂽ̗̈֓˂D̂ƂC]V玿͎玿ɂ鎲˂𐧌䂷dvȃ^pN𔭌ĂƍlDdvȂƂɁC]V玿ɔ^pN̋@\͂CtHQłFGF8]V玿̗̖̌`ɕKvł邱ƂĂ<a href="#R51"><sup>51)</sup></a>Dq{GNg|[V@ɂFGF8ُIɔƁC㓪ɂĈُIȃo삪UꂽDɁCُ̈Iȃǒ`͎玿̎̃g|OtBbNȓ˂ɂe<a href="#R52"><sup>52)</sup></a>D̂悤ɁC玿̎̃g|OtBbNȓ˂́CI]ɂ킦]V玿ɔ^pNɂ萧䂳ĂD
@玿͓̎ʉ߂̂]V玿ɐN邪C̉ߒɂ͑]V玿ɂނ玿s̎K{łDƂ΁C玿s̃pCIjATuv[gj[j󂷂Ǝ玿̎̓˂Ɉُ킪<a href="#R53"><sup>53)</sup></a>D1990NC玿s̎Ǝ玿̎ƂɂďôC݂Ɏ˂KChƂnhVFCNf񏥂ꂽ<a href="#R54"><sup>54)</sup></a>i<a href="#F5">}5c</a>jD̂̂CTbr1CFez-likeCPax6CGbx2CEmx2ȂǁC܂܂ȓ]ʈq̕ψك}EX̉͂C玿s̎Ǝ玿̎̓˂݂͌Ɉˑ邱ƂCnhVFCNfx񍐂Ȃꂽ<a href="#R43"><sup>43)</sup></a>DŁC̎̂̑ݍp݂̑ɔےIȕ񍐂DƂ΁C玿s̎Ǝ玿̎Ƃ͑]V玿̒ԑтɂĈقȂɑ݂邽߁CړIɂ͑ݍpȂ̂ł͂ȂƂ̂ł<a href="#R55"><sup>55)</sup></a>D܂C|{ɂĔ玿s̎Ǝ玿̎̐~Ƃώ@ĂC͗҂̎UƂz肷nhVFCNfƂ͖悤Ɏv<a href="#R56"><sup>56)</sup></a>D
@ŋ߂ɂȂCVɃnhVFCNfx2̕񍐂ȂꂽDȂ킿C玿s݂̎̂ɈُRfBVimbNAEg}EXł͎玿̎͑]V玿ɐNłȂƂꂽ<a href="#R57"><sup>57)</sup></a>D́C玿s̎玿̎̓˂ɕK{ł邱ƂړIȏ؋ƂȂD܂΂ɁC玿j[j󂷂Ɣ玿s̎̓˂Ɉُ̐邱Ƃώ@<a href="#R58"><sup>58)</sup></a>C玿̎玿s̎̓˂ɕK{ł邱ƂꂽD̂悤ɁC܂܂ȎʂnhVFCNfxĂ邪C̋c_Ɍ邽߂ɂ́C̎̂̑ݍpɒړIɂ^pN̓肪KvłD

<h2> 5DKC_X̐VWJ</h2>
@KC_X^pN̋@\𐧌䂷@\ƂāC~ɂǏIȖ|󂪏dvł邱Ƃ񍐂Ă<a href="#R59"><sup>59)</sup></a>DKC_X^pNNetrin1̔񑶍݉łDCCƃ{\[Ƃ|}邪CDCCNetrin1DCC烊{\[𗣂|󂪊Jn邱ƂꂽDۂɁCҐ̌Aj[̎ɑ΂Netrin1̗Uɐ~ɂ|󂪕Kvł邱ƂĂDSemaphorinSlitȂǂق̎KC_X^pNɊւĂǏIȖ|󂪂̋@\ɂĕKvł邱Ƃ炩ɂĂCCڍׂȕqxł̉͂҂D
@ŋ߁C玿̎̔̋@\Ɋւ2̋[񍐂D̏iKɂ鎋̃j[ł̎IȐ_oC玿̎̐L̑x𐧌䂷邱Ƃꂽ<a href="#R60"><sup>60)</sup></a>D̕q@\ƂāC̃j[ɂRobo1̔IȐ_oɂ萧䂳邱Ƃ炩ɂĂD܂Co_oȞ`̊Jn𐧌䂷邱Ƃ񍐂ꂽ<a href="#R61"><sup>61)</sup></a>Do_@ƂזEÕZgjZx̒ቺ]V玿1̐oɑ݂ǒ`𐧌䂷邱ƂCoɂ_oȞ`̐ƂVTO񎦂ꂽD

<h2></h2>
@ł́C]V玿̎vȐ_oHł]C玿ҐH̎C玿̎ǂ̂悤Ɍ`邩ɂĉD܂ł̑̈`qϓ̉͂CP̎KC_X^pN̖ɂĂ̗͐[܂ĂDŁCۂ̐_oȞ`ɂ͕̎KC_X^pNł͂炭ƍlDߔNC_oȞ`̂܂܂ȋǖʂɂāC̎KC_XVOĩNXg[N炩ɂDC]ɂ镡GIȐ_oȞ`̋@\𗝉邽߂ɂ́C̎KC_XVOij[ɂĂǂ̂悤ɓĂ̂𖾂炩ɂKvDɁCŌɏqׂC~ɂǏIȖ|C̏iKɂj[̎IȐ_oC邢́CoȂǐVȊϓ_̌ɂCC]ɂ_oȞ`̗܂܂iނƊ҂D

<h2> </h2>
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</ol>
<div class="au-profile">
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<span class="author">V miYohei Shinmyoj</span>
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<strong>c piHideaki Tanakaj</strong>
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