ӃvOɂ銲זE̋@\̐

<strong>cv \_</strong>
ic`mww uejAgbNEvOj
emailF<a href="mailto:takubo@a2.keio.jp">cvی\_</a>
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̈Zr[, <strong>2</strong>, e012 (2013)@<a href="http://dx.doi.org/10.7875/leading.author.2.e012">DOI: 10.7875/leading.author.2.e012</a>
Keiyo Takubo: <strong>Regulation of stem cells by metabolic programs.</strong>

<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/11/Takubo-2.e012-PDF.pdf" target="_blank"><img class="size-full wp-image-112 alignright" title="Download PDF" src="/images/downloadPDF.png" alt="Download PDF" width="100" height="20" /></a>
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<h2>v </h2>
@ȕ\Ƒ\זÉCזEƂĂ̐ۂ߂ɌŗL̓]ʈq̃ZbgɂƂÂ]ʐlbg[NێĂDāC]ʐlbg[N̉ł́C܂܂ȊזEɌŗL̍זEwIȌۂs邽߂ɑӃvONCKvɉGlM[ʉ݂łATPӎYYĂDߔNCjb`ɂȇ튲זECESזE邢iPSזEƂ\זEł́CזEƂ͈قȂӃvOێĂ邱ƂoꂽDāCӃvOꎩ̂זË̖ێ⎩ȕ\CÎ~Ԃ̈ێȂǂɊ^Ă邱Ƃ炩ɂȂĂDזEɂӃvÓ̗CזȆ╪זE̎YƂĐÂɂZp̊JC܂C񊲍זEWIƂ鎡Ð헪̍ɂ^邱ƂCӂ̎犲זEVXe𗝉dv͑ĂD

<h2>͂߂</h2>
@gDזE͎ȕ\Ƒ\זȄWcłCgD̔P퐫̈ێ̗vƂċ@\DזEK肷]ʈqCזEێłgjb`h̃VOíCȕCΏ̂ȕCÎ~Ԃ̈ێCCVCjb`ւ̃z[~OȂǁCזEɓL̐ۂs邽߂̃GlM[炷ӃvONƍlĂDߔNCזE͂߂Ƃe̊זEVXẻ͂C܂ŕsłזEɓL̑ӓƂ̕q@\oꂽĎʁCזEɂӃvO͍P퐫̈ێV̖hɕsȖ͂Ă邱Ƃ炩ɂȂDŁCזÊȂłC\|{ɂێ鑽\זEɂĂCזËێ⃊vO~Oɂ鑽\̊l̉ߒɂāCӂ̐䂪dvȖ͂Ƃ炩ɂȂĂD
@ł́CESזEiembryonic stem cellC󐫊זEjiPSזEiinduced pluripotent stem cellClH\זEjƂ\זECсCMނ̍jb`ɑ݂鑢זE𒆐SƂāCזËێCBCCāCvO~ỎߒɂӃvOƂ̐@\ɂĉD

<h2>1D\זËێѕ̂Ƃꂼ̑ӂ̓</h2>
@ՖEɂזEł́CזEփOR[XAGlut1Glut3̔OR[X̎荞ݔ\ĎʁC𓜌n̑ӗC_̎Y\ƂmĂ<a href="#R1"><sup>1,2)</sup></a>i<a href="#F1">}1a</a>jD𓜌nɈˑӓՖEɂďdvł邱Ƃ́Cẻ𓜌n̍yfƒOvƂȂ邱Ƃx<a href="#R3"><sup>3-6)</sup></a>DՖEł͉𓜌nłȂ~gRhAɂ_I_̊܂_f̏Ȃ邱ƂmĂ邪<a href="#R7"><sup>7)</sup></a>ĆCނh{Ot̃~gRhAdʂۂƂɂ̂łCזẼ~gRhA͖dʂ̒ႢԂۂĂ<a href="#R8"><sup>8)</sup></a>D

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@\זEɂӃvO</strong>
iaj\זE̖ێӃvOD𓜌n̊ƁC𓜌n̕oHłyg[X_oH̊F߂Cyg[X_oH͊j_YDATP͂ɉ𓜌nɂYC~gRhAɂ_I_ɂ_f̏͗}DXIj̑ӂƂɂƂȂOV̊Jɂt_Ɉˑ1-Yfv[Cj_ɂ킦<em>S</em>-AfmV`IjYD<em>S</em>-AfmV`Ij͑\̈ێɕKvȃqXg̃`ɗpD
ibj\זEƂ̑ӃvOD𓜌nуyg[X_oH̑ӗ͒ቺCɁC~gRhAɂ_I_ɂATPYD𓜌nTCAHƋCsr_̓~gRhAւƌ悭^΂D~gRhAYꂽ_f͍זEɂĕsOab__C𑣐iGCRTmChYD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/11/Takubo-2.e012-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2013/11/Takubo-2.e012-Fig.1.png&amp;caption=fig1-caption-text]

@ՖE瓾|{ɂێ鑽\זEłESזEClɉ𓜌nɑ傫ˑӓ<a href="#R9"><sup>9-14)</sup></a>D܂CזEiPSזEւ̃vO~ỎߒɂĂC_I_ւ̈ˑ𓜌n𒆐SƂӂւ̍ĈڍsF߂CiPSזEꂽ̂ESזEƓlɉ𓜌nւ̈ˑDāC\l郊vO~ỎߒɂẮCӓɂĂvO~ONĂD̂ƂC𓜌n̍Ċ͑\}[J[̗UɂċN邱ƂmĂ<a href="#R15"><sup>15)</sup></a>CvO~Ǒグ邱Ƃ̒mĂזȆBiזEɗUꂽʁCӂ͍זȆBɓK𓜌nɃvO~OĂƍlD̂ƂC𓜌n̑jQ_I_̊iPSזEւ̃vO~O}邱ƂCӓԂ̕ω\̊l̑iɍvƍlĂ<a href="#R16"><sup>16,17)</sup></a>D܂C𓜌n̕oHłyg[X_oH̓}EXESזEɂĊĂČoH犈ȍזȆB̂ߕKvȊj_Ăƍl<a href="#R12"><sup>12,18,19)</sup></a>D
@̂悤ɁCESזEł͎_I_̊͒ႭCATP̎Y͉𓜌nɈˑĂDȂ킿C𓜌n̓~gRhAɂӂɔבΓIɊĂƍlD󋵂ɂāC~gRhAɂ_f̏܂dvȖ͂ĂD̓Iɂ́Cdq`BnɂNADHNAD<sup>+</sup>ւƎ_TCAH̑ӗێ邱ƂɂCESזE͍זEɂ_Ҍ̏ԂK؂ɕۂCNG_̎̍CILT|_⃿PgO^_̃A~m_̍i߂Ăƍl<a href="#R20"><sup>20)</sup></a>i<a href="#F1">}1a</a>jDۂɁCESזȄWcŜƂĂ͒Ⴂ~gRhAdʂĈȂŁCΓIɍ~gRhAdʂƒႢ~gRhAdʂƂ蕪ăeg[}̌`\rƁCΓIɍ~gRhAdʂESזÊقIɃeg[}`邱ƂmĂ<a href="#R21"><sup>21)</sup></a>DɁC~gRhAɂăsr_AZ`CoAYsr_Efyf̂ՖE͔Ɉُ悷邱Ƃ<a href="#R22"><sup>22,23)</sup></a>C𓜌nƓlɁC~gRhAɂđӃvOK؂Ɉێ邱Ƃ͑\זËێɕsł邱Ƃ킩D
@ŁC}EXESזE͑\SۂGsQm̏Ԃێ邽߁C|ñXIj̎荞݂ƂɕKvƂĂD́Cق̐ۉזEזEɂ݂͂Ȃł<a href="#R24"><sup>24)</sup></a>DɁC荞܂ꂽXIjOVƃAZ`CoAֈىƂ̗yfłXIj_yf́CՖECESזECiPSזEɂĔ̏㏸Ă邱ƂmĂD̃XIj_yf锽ɂ蓾ꂽOV́C~gRhAɂăOV̊Jɂ͂炭OVEY_yfɂCזEɂėt_Ɉˑ1-Yfv[ێ邽߂ɗpi<a href="#F1">}1a</a>jDOVEY_yf̓XIj_yfƓlɑ\זEɂčĂ<a href="#R25"><sup>25)</sup></a>DXIj_yf̑jQ┭̗}ɂ}EXESזȆB͗}邱ƂCXIjɗRӎY͑\זËێɕKvłƍlDXIj_yfƃOVEY_yf5-`egqht_̎YUC5-`egqht_-zVXeC`gXtF[[zVXeC̃`Ij̍Đ𑣐iĎʁCqXgH34Ԗڂ̃Wc̃g`ɂă`^C<em>S</em>-AfmV`Ij̎YU<a href="#R25"><sup>25)</sup></a>DqXgH34Ԗڂ̃Wc̃g`́C\ێƎȕ\Sۂ郆[N}`̊J\̈ێ̂ߕKvłDɁCXIj_yft_Ɉˑ1-Yfv[͊j_̍𑣐i邽<a href="#R24"><sup>24)</sup></a>CB̑\זEێ邽߂ɓs悢ƍlD
@ŁCESזEĂƂɂ͉𓜌n̑ӗቺCXIjDŎ荞݃OVYƂӓDɁC~gRhAɂ_I_OR[X⎉b_ɗRӎYɂ쓮悤ɂȂ<a href="#R9"><sup>9,24,26,27)</sup></a>i<a href="#F1">}1b</a>jĎʁC_f̎YזE̎_Ҍ̊͂_ԂւƂނDƂƁCESזEɂ͎_₷Yfd܂ޕsOab_݂D̂߁CזEɂĊ_f킪Y悤ɂȂƁC炪_GCRTmCh悤ɂȂDGCRTmChoH̑jQ܂킦邱ƂɂESזȆ\̈ێ͑i邱ƂmĂ邱Ƃ<a href="#R28"><sup>28)</sup></a>Cӓ̕ωɂYGCRTmChESזE̖킹CւƂނ킹ƍlD̂悤ɁCזEƑ\זEƂ͑ӓقȂ邽߁C܂p邱Ƃɂ蕪זEIɎY邱Ƃ\ɂȂD̈ႪCӓ𗘗p\זES؍זE̗UnłDِ̐SؑOזE͓_荞Ŏ_I_oH邱ƂmĂ<a href="#R29"><sup>29)</sup></a>DqgESזEiPSזES؍זE𕪉Ƃɔ|ñOR[X_킦ĂƁCt̂瑽\זE܂܂Ȃx̍@\IȐS؍זE𓾂邱Ƃł<a href="#R30"><sup>30)</sup></a>D܂CזEƕזȆӓ̗́CזEѕזEꂼɐVZp炷\D

<h2>2DÎ~Ԃɂ鐬̂̊זȆӓ</h2>
@˂ɑBĂESזEƂ͈قȂĈ̑̊זE͐Î~ԂɂD̓Iɂ́C̑זEԗtnזEC]̐_oזECѕoẄ̕\犲זEؓ̉qזECÎ~Ԃ̊זẼJeS[Ɋ܂܂DʓIɁC̎̊זE͊_fɂזEQ̂V邱ƂȂUɂ킽鎩ȕ\ێ邽߁CזEÎ~ɂƍlĂ<a href="#R31"><sup>31)</sup></a>D
@nɂāCِ␶シ̍ł͑זE͊ɑBĂDΏƓIɁĈł͑זE͍jb`ɂזEÎ~ɈێĂC̕̕px̓}EXł1451ƌvZꐶU5x􂵂ȂƌςĂ<a href="#R32"><sup>32)</sup></a>DזE͊oȂǊȇXgXׂꂽƂɂ͊ɑB邪CЂƂёB͂߂זECӂѐÎ~Ԃɂǂ邱Ƃ̂ł邱ƂmĂ<a href="#R32"><sup>32)</sup></a>DCזE③OזEɂ鎞󋵂ɉӂ̐@\͕słD
@̑זEƑOזȆӃvt@C邽߁C}EXʂ̑זECOזECזEW߂ăLs[dCj-sԌ^ʕ͌vɂ郁^{[͂{<a href="#R33"><sup>33)</sup></a>CזEɂĉ𓜌n̊Ӄvt@CDۂɁC<em>in vitro</em>ɂāCזẼ~gRhAɂ_I_jQĂזE̓̂ЂƂłSPiside populationj`͂悭ۂ邪C𓜌njQƂSP`͈ێȂDāĈ̑זEɂĉ𓜌n͊ĂƍlDӓɂ́C̒_f̔ɂ𓜌ñ}X^[M[^[łHIF-1邱ƂdvłƍlĂDHIF-1bHLH-PAS^̓]ʈqłCʏ̑C̎_fł͎_fɈˑ̃v_yfƃAXpM_yfɂCODDhC̃vcC-TADhC̃AXpMcꂼꐅ_ĂDODDhC̃vc_ꂽHIF-1́CrL`K[[łVHLɂFꃆrL`-veA\[nɂ蕪D܂CC-TADhC̃AXpMc_ꂽHIF-1́C]ʈqp300/CBPƑݍpłȂȂ邽߁C̓]ʊtɔłȂȂDŁC_f̊ł̓v_yfуAXpM_yf͊߁CHIF-1͈肵đ݂ł悤ɂȂC_fɔˑ̃TujbgłHIF-1ƂƂɊjւƈڍsāCweʑ̂̓]ʈqHIF-1ƂĒ_f̊ɓK邽߂ɕKvȈ`q̔𐧌䂷D
@HIF-1זEł́CזEƂĂ̊QƓɁC~gRhAɂ銈_f̎Y𓜌n̊ቺ<a href="#R33"><sup>33,34)</sup></a>DŁCVHLweŌזEł͊_f̎YDɁCVHLzŌזEł̓~gRhA̗ʂɌDזE͊_fɑ΂ƎłC_fւ̉ߏȔI͊זEɃA|g[VX╪UזĚ͊܂˂ƂmĂ邱Ƃ<a href="#R35"><sup>35,36)</sup></a>CזEɂāCHIF-1̓~gRhAւ̑ӗ}_f̎YቺC̈ŁC𓜌nĊזEێĂ邱Ƃ<a href="#R33"><sup>33,34)</sup></a>i<a href="#F2">}2a</a>jDlɁC_f̊ɂ_oזE_fւ̔Iɑ΂l̔ƂmĂ<a href="#R37"><sup>37)</sup></a>Dώ@́C𓜌n̊͒PȂ_f̊ւ̓K@\ł͂ȂCÎ~ɂ銲זËێɕKvȑӃvOł邱ƂĂDۂɁCHIF-1̔ꎩ̂͑זEɓٓIȓ]ʈqłMeis1ɂ]ʂ̒iKŗUшێĂ<a href="#R38"><sup>38)</sup></a>ČʂƂāC𓜌n̍yf̔ێĂƍlDHIF-1̓t@~[^pNłHIF-2ƋʂWI`qxƂĂ邪ĈɂHIF-2זE̊זEƂĂ̊ɂُ͈̂ȂƂ<a href="#R39"><sup>39)</sup></a>CHIF-1ɓٓIȕWI`q̂邱ƂĂD܂CזĚ͍ǂ̋ɂȂזEɂ_fԂێĂƂ񍐂<a href="#R40"><sup>40)</sup></a>Cɍ̒_f̕ʂɑזEǍ݂Ƃg_fjb`hfCȂ炩̃jb`̃VOiזEɂ_f̏܂ޑӓCזE̒_fԂ̈ێɊ^Ă\ĂD܂CזȆӃvO̎ȕ\̈ێɕK{ł̂CƂC_f̊ɑ΂邽ȂK@\ł̂͂܂m肵ĂȂD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@זEёOזEɂӃvO</strong>
iajÎ~̑זEɂӃvOD_f̊jb`qC]ʈqMeis1ɂCHIF-1̔ш艻UDHIF-1͉𓜌n̍yf̔Csr_Efyf_yfiPdkj̗̔U~gRhAƉ𓜌nƂECזEVɂȂ銈_f̎Y}C𓜌nDʂ̑ӂUD
ibjBĂ鑢זEёOזEɂӃvODCX-AktVOi`BnȂǂɂ𓜌n͑iD܂CE_yfPTPMT1sr_̎_ɂ~gRhAɂ_I_iC_f킪ɎYāCGCRTmCh̎YiDBUCX-AktVOi`BnɂC]ʈqFoxO_f̎Y̗}@\サĂCmTORAMPK̊ɂ~gRhA̐U邱ƂC~gRhAɂATP̎YiĎʂƂāCB╪isD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/11/Takubo-2.e012-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2013/11/Takubo-2.e012-Fig.2.png&amp;caption=fig2-caption-text]

@āCזEESזEƓlɃ~gRhA̗ʂȂC`ԊwIɂnłCႢ~gRhAdʂƏȂNADH̗ʂƂ񍐂Ă<a href="#R38"><sup>38,41)</sup></a>D~gRhAdʂ̌`镪q@\ƂẮCsr_Efyfɑ΂郊_yfɂ̂Dsr_Efyf̓~gRhAɂĉ𓜌nɗRsr_AZ`CoAւƕϊDsr_Efyf_yf́Csr_Efyf_邱Ƃɂ肻̊}Dsr_Efyf̃_̏ԂƂCۂɁCזEł͑OזEɔ׃sr_Efyf͍_ĂCsr_Efyf_yf̊̍Ƃꂽ<a href="#R33"><sup>33)</sup></a>i<a href="#F2">}2a</a>jDMނł́Csr_Efyf_yf<em>Pdk1</em>`q`<em>Pdk4</em>`q܂ł4̈`qɃR[hꂽt@~[`ĂDHIF-1̔ƃsr_Efyf_yf̔Ƃ̑ւɂČƁCPdk2Pdk4HIF-1̔ʂƐ̑ւDɁCHIF-1זËڐAɂ鐶\ُ̈Pdk2邢Pdk4̉ߏ蔭ɂ񕜂邱ƂCHIF-1̋@\Iȉ^pNƍlDPdk2邢Pdk4זE͉𓜌n̊̒ቺF߁C~gRhA̗ʂ̑Ɗ_f̎Y̑F߂D܂CזE̘iɂזEV̌`DāCPdk2Pdk4͑זȆӓێ邽ߏdvȋ@\͂Ăƍl<a href="#R33"><sup>33)</sup></a>Dct@~[o[łPdk1Pdk3ɂĂזEɂčĂ邱Ƃ񍐂Ă<a href="#R42"><sup>42)</sup></a>CPdkt@~[͊זȆӓƊזEƂĂ̊ƂIɈێĂƎvDC~gRhAɂGlM[ӂQĂψك}EXłCזȆӓƊזEƂĂ̊͏Q邽<a href="#R43"><sup>43-46)</sup></a>C~gRhAɂGlM[ӂ𓜌nƓlɏdvł邱ƂĂD
@ɁCP퐫̈ێłȂᇂ̔ɂ~gRhAɗRӎY̊^Ă邱ƂĂDTCAH̒ԑӎYł郿PgO^_́CqXg̃WcE`yfłJmjChCܗL^qXgE`yf𔭊邽߂ɕKvł邱ƂmĂDTCAH̍yfłC\NG_Efyf̃AC\UCIDH1IDH2̑̍זEψق́C]ᇂ}aȂǂ̎ᇂɂĔF߂DψIDH1ψIDH2̓PgO^_2-qhLVO^_Y銈lĂ邽߁CPgO^_̗ʂቺDȂ킿CJmjChCܗL^qXgE`yf̊ቺC{͒E`ׂqXgɈُ悷DgDזÊ̕ƂɃqXg̒E`dvł邱Ƃ͒mĂCۂɁCψIDH̔͑זȆ̕jQU邱ƂmĂ<a href="#R47"><sup>47,48)</sup></a>DŁCψIDH̓qXg̃`łȂDNÃ`̏ԂɂeyڂDTET2̓PgO^_Ɉˑ5-`VgV5-qhLV`VgVւƕϊyfłCIDHψقɂ郿PgO^_̌ɂƂȂቺD5-qhLV`VgV͍זEDNAC@\ɂ񃁃`VgVւƒuĒE`DȂ킿CψIDHɂTET2̍yf̒ቺ́C5-qhLV`VgV̎Y}DNÃ`𘴐iD܂C2-qhLVO^_̌ŵِł (<em>R</em>)-Gi`I}[̓v_yf̊𘴐i邽߁CזEɂHIF-̗ʂቺ邱ƂmĂ<a href="#R49"><sup>49)</sup></a>CӎY̕ωɂ͂܂邳܂܂ȕω̑aƂčזȆB╪Ɉُ킪CᇂƍlD
@ŁCɑ݂ЂƂ̊זEłԗtnזE_f̊ɂ邱ƂmĂDԗtnזE番Đ鍜זEƔׂƁCԗtnזE͉𓜌n̍yfCŁC~gRhAɂ_I_ɂ͂炭yf̔͒ႢƂC͂C𓜌nɈˑĂ邱ƂĂ<a href="#R50"><sup>50)</sup></a>DԗtnזEꎩ̂́Cʏ̑C̎_fł̔|{ɂĂ͎_f̍_I_𗘗pđB邱ƂmĂCRj[̌`\ƂmĂDC̑㏞ƂčזEV̌XCȕ\₷Ȃ<a href="#R51"><sup>51,52)</sup></a>DāC𓜌nɈˑĂ̂͂Ȃ鍜̒_f̊ւ̓KłƂĂCʂƂāCזE̊ێ邽߂ɂ͗LȐ헪łƂDԗtnזE͑זẼjb`Ƃċ@\邱ƂmĂ<a href="#R53"><sup>53)</sup></a>CߐڂזEǂ̑ӓɋIɐ䂳ꑊ݂ɉeĂ邩́CC𖾂ׂۑłD

<h2>3DB銲זEёOזȆӓ</h2>
@Î~Ԃ̊זEɂ킦CBɂ銲זEOזEgD̍P퐫̈ێɂďdvȖ͂ƂmĂDזEƁC番Đ鍜n̑OזẼveI[rƁCÎ~ɂ鑢זE͉𓜌nɈˑĂ̂ɑ΂COזEł͍DCI𓜂Ǝ_I_𓯎ɗpĂ邱Ƃi<a href="#F2">}2b</a>jDۂɁC𓜌n̍ŏ̔G}wL\Li[[̃AC\UC̔ɒڂƁCזEł͂ɉ𓜌nATP̎Y𑣐iHk1̔Cn̑OזEł̓yg[X_oH̊b_̐𑣐iƂHk2Hk3̔<a href="#R42"><sup>42,54)</sup></a>DāCזEł͉𓜌nɃGlM[̎YɗpCOזEł͉𓜌nىpɗpĂƍlDn̕ɕKvȓ]ʈqłPU.1Hk3̔U邱ƂCזẼ̕vOڂɑӂ𐧌䂵Ă邱ƂDŁCsr_Efyf_yf̔ɂĂCOזEɂĔቺ邱Ƃ獜nւ̕ɂƂȂ_I_̗}邱Ƃ<a href="#R33"><sup>33,42)</sup></a>Dɂ킦C~gRhAɂJWIs̍̉ߒŃzXt@`WOZ[_̒E_ɂ͂炭E_yfPTPMT1́CזE瑢OזEւƕƂɎ_I_ɃXCb`邽ߕKvłƍlĂ<a href="#R55"><sup>55)</sup></a>i<a href="#F2">}2b</a>jD̂悤ɁCOזEɂĎ_I_̃XCb`Ɗ_f̎Y܂邱ƂɂȂD[ƂɁCVEWEoGɂMނ̍nOזEl̍זEimedullary zone progenitorj͕זEYƂɊ_fKvƂ邱ƂmĂ<a href="#R56"><sup>56)</sup></a>CMނɂĂCOזEɂӂ̕ϓƊ_f̎Ŷ̂C\K肷vfł\D܂CזEɔׂƊɑBԂqזÉC_f킪ƍזE̒~ƃA|g[VXUCזEB̂߂ɂ͓Kxȗʂ̊_fKvƂ邱Ƃ񍐂Ă<a href="#R57"><sup>57,58)</sup></a>DāC_fƂYӃvÓCłVUƂזEɂƂ蕉̌ʂ𔭊킯ł͂ȂC_f̗ʂזEC邢́C󋵂ɈˑĊזEƑOזẺ^肷ƍlD

<h2>4DזȆӓƍזEV</h2>
@̐זEgD̍P퐫K؂Ɉێ邱Ƃ́C̘V̐isɂƍlĂD̈ŁCזE̋@\␔ቺ邱Ƃ͘V֘ÄƂȂ邱Ƃz肳ĂDۂɁC_fɂזEQ̒~ς͊זE̎ȕQCV𑣐i邱ƂmĂ<a href="#R46"><sup>46,59)</sup></a>D̘V𐧌䂷邱ƂmĂCX-AktVOi`BnCAMPKVOi`BnCmTORVOi`BnƂẻh{󐫂̃VOi`BńCזE̎ȕƐÎ~ԂƂ̃oXƂ邱ƂɂזEV𐧌䂵Ă邱ƂmĂDƂ΁CCX-AktVOi`Bnɂ蕉ɐ䂳]ʈqFOXOƁCזE̓XgXւ̑ϐזE͊<a href="#R35"><sup>35,36)</sup></a>D܂CAMPKLkb1̌ɂ葢זẼ~gRhAɂُ͈킪NCÎ~ԂĊזE͊<a href="#R43"><sup>43-45)</sup></a>DɁCmTOR1̊𕉂ɐ䂷Tsc1̌ɂ葢זEɂă~gRhACזȆBUCʂƂāCזE͊邱ƂĂ<a href="#R60"><sup>60)</sup></a>Dƈv悤ɁCp}CVɂmTOR1̊}ƁCזE̍זEV}Ďȕ\⑽\ێłƂ̕񍐂ȂĂ<a href="#R61"><sup>61)</sup></a>DӃZT[ɂ킦Csr_Efyf_yfɂ~gRhAւ̑ӗ̐CזE̊𑀍삷邠肻̕WIƂȂ肤Dsr_Efyf̑jQp̂1-A~mG`zXtB_YđזE邢͑OזE|{ƁC̓Y͂͂ȑB̗}pCOזE͎łDƂ낪CזE͑B}ꂽ܂1Jɂ킽|{邱Ƃ\łC̎_łזEƂĂ̕\ʃ}[J[ۂCɈڐAĂ\Ƒ\ێDŁC1-A~mG`zXtB_YĂȂזEł͍ڐÂ̂̐\͊SɎĂD̂ƂC1-A~mG`zXtB_YזÉCYĂȂזEɔ׍זEV̌`̏o}Ă<a href="#R33"><sup>33)</sup></a>Dώ@́CזȆӐɂÎ~Ԃ⎩ȕ\C\ꊇđ삵V}ł\ĂD

<h2></h2>
@זE󋵂ɉӃvOϓ邱Ƃ͐̊{IȐ헪ł邪CזEɂӃvOƁCꂪʂɂ͕sȓ_Dł́C\זEƑזEꂼ̑Ӑ@\ƁC̊זEVXëێɑ΂eɂďЉD݁CזE͂߂Ƃe̊זEɂāCӐvÖێ@\̔ɏdvȖ͂Ƃ񍐂ĂĂDזEɂđӂ𐧌䂷鉻݂͐邽߁ĆCӃvOlדIɐ䂷邱ƂCזE̋@\̐Vϖ@CזE̘V̗}ɂƂÂRV@̊JɂȂ邱Ƃ҂DɁC̊זEƂ񊲍זEƂ̑Ӑ̗̈ٓ́C񊲍זEɓٓIȎÖ@̊JɂȂ邱Ƃ҂D̂ƂƂȂ̂́CזȆӓԗIoIɔcZpłD܂CƂɑ̐זȄꍇɂ́CȂjb`Ƃ̂ƂȂ邽߁CԓIȏx̑Ӊ͂dvƂȂDZpIȍ̂肱ĂƂɂCȏIȒm̖cȏWςƎvꂪȑӂCזEqGL[̊eiKłɐI_Ci~bNɐ䂳Ă邩CЂƂЂƂ炩ɂȂĂ̂ƎvD

<h2> </h2>
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</ol>
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