_oǂё̐ߒtɕ̎זE̐

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iwߘYLOȊwZ^[ j
emailF<a href="mailto:takemoto.tatsuya@tokushima-u.ac.jp">|{</a>
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̈Zr[, <strong>3</strong>, e007 (2014)@<a href="http://dx.doi.org/10.7875/leading.author.3.e007">DOI: 10.7875/leading.author.3.e007</a>
Tatsuya Takemoto: <strong>Regulation of the axial stem cells deriving neural tube and paraxial mesoderm.</strong>

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<h2>v </h2>
@Ғœ\鑽lȍזÉC̏ɑ\זȄWcłGsuXgo_ƂĕDȏ̋Lqɂ΁C̎͂܂OtCtCtɕCɂזẺ^΂߂ƂĂDāC_oǂ͊Ot\ƕ邱Ƃɂ蕪ƍlĂDȂCŋ߂̌ɂC̊̐_oǂ͑̐ߒtƂ̋ʂ̑O̍זEł̎זE番邱ƂꂽD̐VזE^̕_ł̎זEC_oǂ̍זEɕ邩̐ߒt̍זEɕ邩́C2̓]ʈqCSox2Tbx6ɂ萧䂳ĂDTbx6͑̐ߒtƂȂזEɂ<em>Sox2</em>`q̔}邱Ƃɂ_oǂ̔}D̎זESox2Tbx6Ɉˑ2̑̍זEnɕCWnt-BrachyuryVOi`BoHɈˑĈێ邱ƂɂC̊̑gDiKIɌ`ĂD

<h2>͂߂</h2>
@Ғœ̏̔ɂčŏɌ`̂̑gDłD̂̂C̊̑gD̐isƂƂ򕔂ɂނiKIɌ`D}EXɂẮCDP7`8ڂɂē̑gD`CÂāC̊iсCj̑gD5iDP8`13ځjČ`D̎ł́C_oǂ𒆐SƂđɑ̐ߒtCԒtCt`D܂C_oǂ̕ɂ͐ҍѓt`i<a href="#F1">}1</a>jD̊є̒iKIȌ`͐ҒœۑĂDjgɂẮCz18`22Ԃ̎ɓ`C̊́C`ꂽ̂C6ĒiKIɌ`D̂悤ɁC̊̑gD򕔂ɂĒiKIɕtȂ`ߒ̎LƂԁD̎LɂāC̊̑gD͌ד̏ł錴Ƃ̎ӂ̃GsuXgi՗twj邢͔肩狟זEɂ`D

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@}EXɂ̊̑gD̕z</strong>
DP9ڂƑ̊̉fؕЁD̊ɂ͐_oǂƑ̐ߒt̂قCԒtit`jCti̕ǂȂǂ`jCti`j`D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/07/Takemoto-3.e007-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2014/07/Takemoto-3.e007-Fig.1.png&amp;caption=fig1-caption-text]


<h2>1DזEň疾炩ɂȂ_oǂё̐ߒtɕ̎זE</h2>
@ł́C̎ӂ̗̈ɂ͂ǂזÊ݂낤H@̎ӂ̗̈̋ɕCꂼ̋ɂזEǂ̑̍זEnւƊ^͂ꂽ<a href="#R1"><sup>1,2)</sup></a>D̑O[łm[h̍זE͐_oǂ̕CҍCǂ̔wւƊ^C̍זE͑̐߂ёtւƕDŁC_oǂւƊ^זȆ͌̑ȎɂGsuXgi}EXł͌̑O4/5̑Cjgł͌̑O1/2̑jɑ݂ĂD̗̈ɂ́C̐ߒtւƊ^זE܂܂ĂD̐_oǂɂȂזEё̐ߒtɂȂזE݂GsuXg͌𑤕GsuXgicaudal lateral epiblastjƂ΂<a href="#R2"><sup>2)</sup></a>i<a href="#F2">}2</a>jD_oǂւƊ^זE̓m[hƌƂ̋ڂłm[h-Einode-streak borderjɂ݂ĂC̗̈̍זE̐ߒtւƊ^邱ƂĂD𑤕GsuXgуm[h-E̍זÉĈɌ`ҍ-_oǔ[Eichordoneural hingejɂ^āC̐_oǂё̐ߒtɍזEi<a href="#F2">}2</a>jD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@}EXɂ錴𑤕GsuXgCm[h-ECҍ-_oǔ[Ëʒu</strong>
iajw݂DP8ڂƂ̉fؕЁD̑O4/5̑̃GsuXg𑤕GsuXgicaudal lateral epiblastjCƃm[h̋ڂm[h-Einode-streak borderjƂԁD𑤕GsuXgɑ݂זE͐_oё̐ߒtւƊ^Dm[h-E̍זE͐_oǒCҍC̐ߒtւƊ^D
ibj𑤕GsuXgƃm[h-E̍זÉĈɌ`̐ҍ-_oǔ[Eichordoneural hingejɂǍ݂āC̐_oǁCҍC̐ߒtւƊ^D
icj𑤕GsuXgCm[h-ECҍ-_oǔ[E̍זEnD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/07/Takemoto-3.e007-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2014/07/Takemoto-3.e007-Fig.2.png&amp;caption=fig2-caption-text]

@זE^n}̌ʂC𑤕GsuXgCm[h-ECҍ-_oǔ[Eɂ́C̊̑̍̕זEnɊ^ł銲זE݂C̎̐LɂƂȂ̍זEnĂ\ꂽ<a href="#R1"><sup>1,2)</sup></a>D̉́CgDɕҍ-_oǔ[E̍זEC̎LJnDP8ڂ̃m[h-EɈڐAāC̕\͂xꂽDm[h-EɈڐAꂽҍ-_oǔ[E̍זÉC{Cҍ-_oǔ[E̍זE̍̕זÊ݂Ȃ炸Ĉ菉ɕ鋹̐_oǂ̐ߒt̍זEɂD܂C󂪔DP12ڂւƔ̂CēxCҍ-_oǔ[E̍זEoʂ̔DP8ڂ̃m[h-EɈڐAƁC̍זE͂ӂы⍘̑gDւƊ^Dľ̓jgłsĂD̊̑gĎ`JnXe[W6ɂāC̎ӂ̃GsuXg̏̍זEWCWꂽזÊǂ̗̈̑gDւƊ^̂͂ꂽ<a href="#R3"><sup>3)</sup></a>DWꂽזËꕔ͒P̑̍זEnւƊ^Cꕔ͐_oǂƑ̐ߒtƂ̑̍זEnւƊ^D܂CjgɂāCXe[W15iłɔ̓r܂ł̌`͊Ăj̐ҍ-_oǔ[E̍זEXe[W8i`Ă鎞jɈڐAƁC}EXōsꂽƓlɁC蕫̑gDł鋹̑gDւƊ^<a href="#R4"><sup>4)</sup></a>DזE^n}זEڐǍC𑤕GsuXgCm[h-ECҍ-_oǔ[Eɂ́C̊̑gD̑̍̕זEnւƊ^ł銲זȆ݂\ꂽD܂C̑gDɕҍ-_oǔ[E̍זEłĂC⍘̑̊̑gDɕ\͂ێĂ邱ƂꂽDȂČ́Cł͂邪̍זE̕W邢͈ڐǍʂłƂC̑̍זEnɊ^ł銲זÊ݂C邢́Cꂼ̑̍זȆO̍זEʂɑ݂̂𖾊mɋʂ邱Ƃ͂łȂD
@2009NC1זEWĂ̍זE^Lq錤sꂽ<a href="#R5"><sup>5)</sup></a>Ďł́Cs^<em>LacZ</em>`qׂ̂Ă̍זEŔgXWFjbN}EXpꂽD̕s^<em>LacZ</em>`q͔ĂȂC̓ɂd̈悪gɂ菜邱ƂŔLacZ悤ɁC܂C̑g̕px󂠂1ȉ̍זEŋN悤ɐ݌vĂDāCɂLacZzזEƂĐFꂽזÉCȑO̔̒iKőgN1זEɗR邱ƂɂȂDLacZzזE̐瑊g̋N̎i܂CWꂽj𐄒肷邱ƂłĎCDP8`10ڂɕWꂽ1זEɗRזE_oǂђt̗Ɋ^C܂C̎̐L[łɂ^邱Ƃ炩ɂȂĎɂCDP8`10ڂɁC_oǂђt̗Ɋ^鋤ʂ̑O̍זEł̎זȆ݂ꂽD
@ȂČł̂ǂ̗̈1זEŏɕWꂽ̂m邱Ƃ͂łC_oǂђtɊ^鋤ʂ̑O̍זE̕z͕ŝ܂܂łD܂C̋ʂ̑O̍זEǂɂ_oǂ邢͒tɕ̂słD

<h2>2D̎זE̐_oǂ邢͒tւ̕𐧌䂷邵</h2>
@M҂́C_oɂēٓIɔ<em>Sox2</em>`q̔̐@\o_ƂāC̊̐_o̐ߒtƕ邱Ƃɂ蕪邱Ƃ𖾂炩ɂ<a href="#R6"><sup>6,7)</sup></a>D_oɂ<em>Sox2</em>`q̔́C̗̈悠邢͔̒iKɉĈقȂGnT[ɂSĂ<a href="#R8"><sup>8)</sup></a>D̂CN1GnT[N2GnT[́CꂼC̊ѓɂ<em>Sox2</em>`q̔̊JnɊ֗^Dꂼ̔̐@\͂܂قȂ邱ƂC̊ƓƂł͐_o݂̔̂قȂ邱Ƃꂽ<a href="#R9"><sup>9,10)</sup></a>D
@<em>Sox2</em>`qN1GnT[͌Ƃ̎ӂ̃GsuXgɂĊC̐isɂƂȂ̎ӂ̗̈悩痣ꂽזEł͊D̗̊̈́C_oǂɕזEƑ̐ߒtɕזEƂ݂錴𑤕GsuXgƂقڈvD\zǂCN1GnT[ꂽזE͐_o݂̂Ȃ炸Cʉ߂Ēẗ̗ւƊדđ̐ߒtւƕDẗւƈړזEłN1GnT[si<a href="#F3">}3a</a>jDł́C<em>Sox2</em>`qN1GnT[ĂtɕזÉC_o̍זEɂȂ肤̂낤H@̓́CȑOC1998Nɔ\ꂽ_ɂD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@̎זE̐</strong>
iaj̎זE_oё̐ߒt̍זEւ̐̕D<em>Sox2</em>`qN1GnT[͌𑤕GsuXgɂĊDȂC<em>Sox2</em>`qꎩ̂̔BMPVOiɂ}ĂD̂Cm[h番傳BMPVOijQ^pNłChordinNogginɂBMPVOiɂ}ꂽזEł́C<em>Sox2</em>`qĐ_oւƕDCʉ߂̓ւƈړזEł́CTbx6̍pɂN1GnT[sD
ibjTbx6mbNAEg}EXł́C{͑̐ߒtɕ̈ɈُIɐ_oǂ`D<em>Sox2</em>`qN1GnT[dψك}EXł́Cُ̈IȐ_oǂ̌`݂ȂȂD
icjWntVOiɂ̎זE̐DWntVOi<em>Sox2</em>`qN1GnT[邪C<em>Sox2</em>`qꎩ̂̔͗}ĂD܂C<em>Tbx6</em>`q̔WntVOiɂ萧䂳ĂDWntVOiȂȂƑ̎̐L~邱ƂC̎זËێɏdvłƍlD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/07/Takemoto-3.e007-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2014/07/Takemoto-3.e007-Fig.3.png&amp;caption=fig3-caption-text]

@1998NCTbx6mbNAEg}EX쐻ꂻ̕\^񍐂ꂽ<a href="#R11"><sup>11)</sup></a>D<em>Tbx6</em>`qT{bNX^̓]ʈqR[hCʉ߂זEɂĔJnĈ̂tɂĔێ<a href="#R12"><sup>12)</sup></a>D̗̈ɂĕ\wł̂݊<em>Sox2</em>`qN1GnT[Ƃ͔rIɔĂDTbx6mbNAEg}EX͔DP9ڂɂČȕ\^ώ@ꂽDł̐ɐ_oǂ`C̗ɍؓւƕ̐ߒt`邪CTbx6mbNAEg}EXł͑̐ߒt`ꂸCɂ̏ꏊɈُIȐ_oǂ`ꂽi<a href="#F3">}3b</a>jD̂Ƃ́C]ʈqTbx6̐ߒtƂȂזEɂĐ_oǂւ̕}Ă邱ƂĂDȂC͂ȏ̉͂͂ȂȂD
@M҂́CTbx6̖𖾂炩ɂ邱ƂɂC_oƑ̐ߒtƂʂO̍זE番邱ƂC܂Ĉ݂̕𖾂łƍl<a href="#R7"><sup>7,13)</sup></a>DTbx6mbNAEg}EXł͒ẗ̗֊ד̂̍זEɂĂ<em>Sox2</em>`qN1GnT[sꂸCЂÂԂێꂽĎʁC̐ߒtƂȂזEɂ<em>Sox2</em>`qُIɊꂽDāCُI<em>Sox2</em>`q𔭌זÉC{Ȃ̐ߒť`̈ɐ_oǂ`DTbx6mbNAEg}EXɂăQmN1GnT[ƁCtƂȂזEɂ<em>Sox2</em>`qُ̈̔CɁC_oǂẗ̗ɂĈُIɌ`ȂȂi<a href="#F3">}3b</a>jĎCTbx6N1GnT[s<em>Sox2</em>`q̔}邱ƂɂC_oǂ̌`}Ă邱Ƃꂽi<a href="#F3">}3a</a>jDāCN1GnT[̊ɂW錴̎ӂ̗̈̍זEC_oɂ̐ߒtɂȂ肤鋤ʂ̑O̍זEł̎זEł邱ƂꂽD
@M҂̃mbNAEg}EXṕCꂾő̎זȆ݂ؖ̂ł͂ȂDȂCɏЉ1זE̍זEn̉͂̌ʂƂ킹člƁC̎ӂ̗̈ɐ_oǂƒtƂ̋ʂ̑O̍זEł̎זȆ݂邱Ƃ͖炩ł낤<a href="#R13"><sup>13,14)</sup></a>D

<h2>3D̎זEێ邵</h2>
@̎זE͐_oƒt2̑̍זEnɕ\͂ێȂC_o邢͒tɕזEYo邱Ƃɂ̊`ĂD̉ߒɂāC_oւ̕Sox2Ctւ̕Tbx6Ƃ2̓]ʈqɂ肻ꂼSĂ邱Ƃ炩ɂȂDł́C̎זEזEƂĈێ邵݂͂ǂȂĂ̂낤H
@̎זE܂ތ̎ӂ̗̈ł<em>Sox2</em>`qN1GnT[Ă邪C̑啔̍זEł<em>Sox2</em>`q͔ĂȂDāĈꕔ̍זE͌דƂƂN1GnT[sđ̐ߒt̍זEւƕDȂC̎ӂ̍זE<em>Sox2</em>`q𔭌Ȃ̂ł낤H@́C̗̈łBMPVOi̍pɂ<em>Sox2</em>`q̔}Ă邩ł<a href="#R6"><sup>6,7)</sup></a>i<a href="#F3">}3a</a>jDāCm[hłBMPVOȋjQ^pNłChordin邢NogginĂC̎ӂ̍זEłBMPVOiɂ}ĂDBMPVOiꂽזE<em>Sox2</em>`q𔭌Đ_oւƕi<a href="#F3">}3a</a>jDɂ茴̗̈łBMPVOi}ƁC<em>Sox2</em>`q͖̔̈{̔̈Ɋg債āCN1GnT[Ă̈ƈv<a href="#R6"><sup>6,7)</sup></a>D܂C͂̑gD`ȂȂD炭C̎זEׂĐ_o̍זEւƕĂ܂ł낤Dȏ̂ƂCBMPVOi<em>Sox2</em>`q̔}邱Ƃɂ̎זËێɊ֗^ĂƍlD
@܂C܂łɕ񍐂Ă`qψك}EX̕\^CWntVOi]ʈqBrachyuryƂƂɑ̎זËێɊ֗^Ă邱ƂĂ<a href="#R13"><sup>13,14)</sup></a>i<a href="#F3">}3c</a>jDɂĔĂWnt3aBrachyury݂͌̔Ă邱ƂmĂ<a href="#R15"><sup>15)</sup></a>DWnt3ambNAEg}EXBrachyurymbNAEg}EXɂẮC̎ӂ̗̈ɂ<em>Sox2</em>`qُ̈IȔ<em>Tbx6</em>`q̔̏ώ@CȎ̊`ȂȂ<a href="#R16"><sup>16-18)</sup></a>D̊ώ@CWnt-BrachyuryVOi`BoH̕sɂ̎זEێꂸCׂĐ_o̍זEւƕČ͊Ă܂ƍlD܂C<em>Wnt3a</em>`q<em>Brachyury</em>`q͔̔DP13ڂɏ邪Č͔`iLjI^C~OƂvĂDWnt3a̔̏Ƒ̊̌`̏IƂ̊֌ẂC<em>Wnt3a</em>`q̔̒ቺ}EX̌Ă<a href="#R19"><sup>19)</sup></a>D<em>Wnt3a</em>`q̔̒ቺ<em>vt</em>}EX̃zψł͔̌`rŒ~ĒZȃ}EXY܂D܂C<em>vt</em>}EXWnt3ambNAEg}EXƂ̓dwe}EXł͌㎈̑gD`ȂDώ@CWntVOi郌x܂Ƒ̎זE͊đ̊̌`\~Ă܂D
@Wnt3ambNAEg}EX̕\^CWntVOi<em>Sox2</em>`q̔}邱Ƃɂ̎זËێTbx6̔tւ̕𐧌䂵ĂƍlDȂCWntVOi<em>Sox2</em>`qN1GnT[VOîЂƂł<a href="#R6"><sup>6)</sup></a>i<a href="#F3">}3c</a>jDāCWntVOi͕GȐɂC̎זËێ2̑̍זEnւ̕Ƃ̂䂵ĂƍlD݂̂ƂCWntVOiǂ̂悤ɂđ̎זËێƕ̐gĂ̂͂܂킩ĂȂD܂C̎זEێĂƍlWntVOiBMPVOiƂǂ̂悤Ȋ֌Wɂ̂słČۑłD

<h2>4D̎זE`̗̈</h2>
@̎זE`̂́ĈׂĂ̐_o邢͑̐ߒtł͂ȂD̂Ƃ́C̎זE̐ɂ`q̕ψك}EX̕\^DTbx6mbNAEg}EXł́C̐ߒtƂȂ̈ɈُIɐ_oǂ`邪C̕\^݂̂͑7̐߂݂̂łD蕫ł͕sSȂ6̑̐߂`C؂̃}[J[`qł<em>MyoD</em>`q<em>Myf5</em>`qȂǂ<a href="#R7"><sup>7,11)</sup></a>i<a href="#F4">}4</a>jD<em>Wnt3a</em>`q邢<em>Brachyury</em>`qɕψق}EXɂđ̊`ȂȂ邱Ƃ͂łɏqׂC̕ψك}EXɂĂ6̐߂܂ł̐_o⒆t̑gD͐Ɍ`DāC_oɕ邩̐ߒtɕ邩ƂזE^͑̕7̐߂ł̂݋NC蕫̑̐ߒti̓򕔁j͂܂قȂ鐧ɂ`ƍli<a href="#F4">}4</a>jD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@򕔂̒t̍זE͑̎זEɈˑɕ</strong>
iajD
ibjTbx6mbNAEg}EXDŏ6̐߂͒tƂČ`iC߂͕sSjDُIȐ_oǂ̌`򕔂̑̊ł̂݋ND
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/07/Takemoto-3.e007-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2014/07/Takemoto-3.e007-Fig.4.png&amp;caption=fig4-caption-text]

@̐ߒt݂̔̂򕔂Ƒ̊ƂňقȂ邱Ƃ́Cꂼ̑̐ߒtR̍זȄԂ𔽉fĂ\DߔNCGsuXgɑΉ|{זEłGsuXgזÊ̂󂩂ꂽD̃GsuXgזE͔DP8ڂ܂󂩂͎ł邪Cȍ~󂩂͎łȂ<a href="#R20"><sup>20)</sup></a>D܂CꂽGsuXgזÉCDP8ڂ܂ɈڐAƂ܂܂ȑ̍זEnւƊ^邪CDP8ڂ肠ƂɈڐAĂ̍זEւ͕Ȃ<a href="#R20"><sup>20)</sup></a>D̏ɂ܂򕔂CÂđ̊邱ƂlƁC炭6̐߁i򕔁j܂ł̑̐ߒt̓GsuXg璼ڂɕC̑̐ߒt͑̎זEɗRł낤D

<h2>5D_oƑ̐ߒtȊȎ̊̑gD`@\</h2>
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<h2> </h2>
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</ol>
<div class="au-profile">
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