_onɂƉuזE̓Ԃ̐

<strong> ꔎ</strong>
iwƉuwteBAZ^[ Ɖu_Ci~NXj
emailF<a href="mailto:ksuzuki@ifrec.osaka-u.ac.jp">؈ꔎ</a>
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̈Zr[, <strong>4</strong>, e011 (2015)@<a href="http://dx.doi.org/10.7875/leading.author.4.e011">DOI: 10.7875/leading.author.4.e011</a>
Kazuhiro Suzuki: <strong>Control of immune cell dynamics by the sympathetic nervous system.</strong>

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<h2>v </h2>
@_onƉunɑ΂pƂ͌ÂwEĂC̕q@\͒炭słDߔNC_oñCvbgƉuñAEgvbgɕϊ镪q@\炩ɂɂC_onɂƉun̐̌ڂ͂߂Dŋ߂̌C_onD邢̓p̓ԂꂼقȂ镪q@\ɂ萧䂵Ă邱Ƃ炩ɂꂽD̃r[ɂẮC_onɂƉuזE̓Ԃ̐@\𒆐SɁC_onɂƉun̐ɊւŐV̒mɂĉD

<h2>͂߂</h2>
@gƉúhƂt悭ɂD̂ƂC̏ꍇɂČ̂XgXƂ̊֌WłCgXgXɂƉu͂ቺhƂ̂JԂ̒ɂȂĂDɁCXgXƉű@\ɉeڂƂ͕Iɂ񍐂Ă<a href="#R1"><sup>1)</sup></a>DC̃r[̓ǎ҂̑ɂ́CMߐĎ󂯓Ȃ̂ł͂ȂƑzD́CXgXƖƉun̊\킷Ȃ炩̎wŴ͎ƂĂCXgXƉunɍp镪q@\ɂčזEx邢͕qxł̗Â\ɂȂĂȂ߂łD
@_I邢͓̓IȃXgXɂ炳]̊̕ω͑Sg̑ɑ΂܂܂ȉeڂD̎vȓ`BoĤЂƂ_onƕ_onȂ鎩_onłD_onƕ_on͂CҐ_o߂ɒBߑOۂƁC_o߂ɂĐߑOۂ̏IƃVivX`WIƂȂ鑟ɓ˂ߌۂ\DIɁC_on̐ߌۂ̏I̓mAhiC_on̐ߌۂ̏I̓AZ`RoC̎ê𔭌זEɍpDĈɏqׂ悤ɁCp튯ɂ̓mAhiYAhi쓮_o͓˂Ă邪CAZ`RYR쓮_o͂قƂǓ˂ĂȂƂUwIȓ<a href="#R2"><sup>2)</sup></a>DāC_on͖ƉunƂ蒼ړIȃC^[tFCX`ĂƍlDC_onɂƉun̐ɂזEՂ邢͕qՂ̉𖾂߂҂_onɒڂ̂͂̂߂łD̃r[ɂẮC̗jIȔwiӂ܂ȂC_onɂƉun̐@\CɖƉuזE̓Ԃ̐Ƃ؂D

<h2>1D_onɂƉun̐̌j</h2>
@_onɂƉun̗̐̌j́CɂĂ20Iɂ̂ڂ<a href="#R3"><sup>3)</sup></a>DAhiPꌋꂽ̂1901N̂Ƃł邪<a href="#R4"><sup>4,5)</sup></a>Ĉ̂܂ȂCqgɃAhi𓊗^Ɩ̌tɂ锒̐ϓ邱Ƃ񍐂CAhiêhƉuזE̓ԂɉeڂƂꂽ<a href="#R6"><sup>6)</sup></a>D_onɂƉun̐@\݂̑͂߂ĎƂ錤́C͂킪񍐂ĂD1919Nɔ\ꂽ̘_ɂ́CƂ̎sƒ̕saȂǎЉSIȃXgX錋j҂ɂĔÐH\ቺ邱ƂLĂ<a href="#R7"><sup>7)</sup></a>DČ݂悤ɂȂ̂́C1960Nɓ萸_IȃXgXȖƉȕǏɉeڂƂ񍐂Cgpsychoimmunologyhi_Ɖuwj̊TO񏥂Ă̂Ƃł<a href="#R8"><sup>8)</sup></a>D1970Nɂ́Cɐ_ԂƖƉu@\Ƃт_oȊwIȑʂāgpsychoneuroimmunologyhi__oƉuwjTOꂽ<a href="#R9"><sup>9,10)</sup></a>DCqw߂ĂłĎ҂ۂ𕪎q̃xŉƂȂCۂ̋LqɂƂǂ܂邱̊w͓̐Ȋw̒ɂ̂邱Ƃ͂łȂD
@C1980NɓƁCB⍜Ƃ1p튯уp߂BƂ2p튯̂ɂAhi쓮_o˂Ă邱Ƃ`ԊwIȌ疾炩ɂȂC_onɂƉun̐ɂUwIȍꂽ<a href="#R11"><sup>11)</sup></a>DƂ2p튯ɂẮCAhi쓮_oTזȆ݂̈𒆐SƂĕzBזȄW܂郊phE̓ɂ͓荞܂ȂƂ˃p^[Ƃ邱Ƃ킩D[ƂɁCp튯ɂăR쓮_o͌oȂ<a href="#R2"><sup>2)</sup></a>DɁC̖򗝊wIȌCmAhi̎êƉuזE̍זEɔĂ邱Ƃꂽ<a href="#R12"><sup>12)</sup></a>DAhiê̓<sub>1</sub>C<sub>2</sub>C<sub>1</sub>C<sub>2</sub>C<sub>3</sub>5̃Tu^Cvɕނ邪CƉuזEɂ̓<sub>2</sub>AhiêƂLxɔĂ邱Ƃ炩ɂꂽD̒ḿC_on̓͂ƉunɒړIɍp邱Ƃ̂łC_onɂƉun̐̌ӂ_@ɂȂD

<h2>2D_onɂ鉊ǂ̐ɂ镪q</h2>
@_onɂƉun̐ɂmłƂqՂ炩ɂꂽ̂́C21IɓĂ̂ƂłD_o͔]ɋNnċ̓ɕzC̒moƋ@\ǂdvȐ_ołD˂ĂC_oh邱Ƃɂ}EXɃGhgLV𓊗^ۂ̉ǔ}邱ƂmĂ<a href="#R13"><sup>13)</sup></a>CꂪB̃}Nt@[WɔjR`AZ`Rẽ7Tujbgɔ}邱ƂƂ߂ꂽ<a href="#R14"><sup>14)</sup></a>DjR`AZ`Rẽ7Tujbg͐_oזEɂĂ̓CI`l^ễTujbgƂĊdʂ̐Ɋ^邪C}Nt@[WɂĂ͎X̃VOi`BoHNF-B̊jւ̈ڍs܂TNF͂߂Ƃ鉊ǐTCgJC̎Y}<a href="#R15"><sup>15,16)</sup></a>D
@_ỏSH͌IɃR쓮_oɂ\邪Co_o߂Bɓ˂_o̐ߌہiB_oj͗OIɃAhi쓮_ołDł́CBɂăAZ`R͂ǂ狟̂낤D[ƂɁCCD4zTזËꕔmAhi̎hăAZ`RYCBɂAZ`R̋ɂȂĂ邱Ƃ<a href="#R17"><sup>17)</sup></a>D̔C_oǔ𕉂ɐ䂷镪q@\炩ɂC_onɂƉun̐ɂזEՂѕqՂ͂߂Ďꂽi<a href="#F1">}1</a>jDɁC]ւƂނ_őSHio_ojTolllêTCgJCêCh邱Ƃɂ芈dʂƂm𑍍C_őSHƉSH𔽎ˋ|Ƃĉߏȉǔ̋N̂ӂ̂ی삷邵݂񏥂ginflammatory reflexhiǔˁjƖÂꂽ<a href="#R15"><sup>15,16)</sup></a>D

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@_oɂ鉊ǔ̐</strong>
_oƁCBɓ˂_o̐ߌہiB_ojmAhioC̎hĈꕔTזEAZ`R傳DTזEɗRAZ`ŔCjR`AZ`Rẽ7Tujbgi7nAChRjă}Nt@[W̉ǐTCgJC̎Y}D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/08/Suzuki-4.e011-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2015/08/Suzuki-4.e011-Fig.1.png&amp;caption=fig1-caption-text]

@ŋ߁C_onɂ鉊ǐɂVȕqՂ𖾂ꂽDdǂ̃}EXfłIȖƉu]ҐɂāCɊoh邢͍Rd͋؁iq؁j̊oh̐Ґ߂ɂ鉊ǍזE̐N𑣐i邱Ƃ炩ɂꂽ<a href="#R18"><sup>18,19)</sup></a>D̕q@\ƂāCo_o̓͂ǕʂɂċǏIɃAhi쓮_oComAhi<sub>1</sub>AhiêČǓזẼPJC̎YU邱ƂꂽD̋@́CǕʂɂĖƉuזE̐N˂`锽˂Ƃāggateway reflexhƂ΂<a href="#R20"><sup>20)</sup></a>D

<h2>3D_onɂD̓Ԃ̐</h2>
@ɏqׂ悤ɁCAhiêhƉuזE̓ԂɉeڂƂ100Nȏ܂mĂ<a href="#R6"><sup>6)</sup></a>C̕q@\͕słD̂悤ȏ󋵂ɂāC2012NC}EXł͒ԂɔזԂɔ畆ؓȂǂ̖gDɍDWς̂ƓāCtɂD̐邱Ƃ񍐂ꂽ<a href="#R21"><sup>21,22)</sup></a>D_on̊1̂Őĝ̊̍ԑтɏ㏸Cĝ̊̒ႢԑтɒቺƂTYDāC}EX̂悤Ȗs̓ł͖ԂɌ_on̊܂DD̓ԂTYq@\ƂāC_on̓͂<sub>2</sub>Ahiêу<sub>3</sub>AhiêđgĎǓזEɂPJCэזEڒq̔U邱ƂɂCtgDւ̍D̈ڍs𑣐i邱Ƃ炩ɂꂽi<a href="#F2">}2</a>jD܂CD̓Ԃ̊TÝCDւ̒ړIȍpł͂ȂC_onDƂ܂ω邱Ƃɂ`D

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@_onɂD̓Ԃ̐</strong>
TY̒ł鎋j̓͂ɂC_on̊1̂Őĝ̊̍ԑтɏ㏸Cĝ̊̒ႢԑтɒቺƂTYDs̃}EXɂĂ͖ԂɌ_on̊܂CԂɔׂ葽̃mAhioDƁCgĎǓזEɂă<sub>2</sub>Ahiêу<sub>3</sub>AhiêčזEڒqICAM-1уPJCCCL2̔㏸CtgDւ̍D̈ڍsiD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/08/Suzuki-4.e011-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2015/08/Suzuki-4.e011-Fig.2.png&amp;caption=fig2-caption-text]

@CȏIɂC}ɃXgXꍇmAhiP񓊗^ꍇɂ͖̌tɂD̐͑邱ƂmĂ<a href="#R23"><sup>23)</sup></a>C̒mƂ񖵏D}͂ȃmAhi̓͂́C_on̊̊TYɂƂȂmAhi̓͂ɏɕωꍇƂ͈قȂ镪q@\ɂCD̓Ԃɍp̂ȂD

<h2>4D_onɂ郊p̍ďz̐</h2>
@mAhi𓊗^ƁCD̏ꍇƂ͑ΏƓIɁČtɂ郊p̐͌<a href="#R23"><sup>23)</sup></a>DM҂́CpɃ<sub>2</sub>AhiêĂ邱ƂɒڂC<sub>2</sub>Ahiê̑IIȎh}EXɓ^ƂCt݂̂Ȃ炸ptɂĂp̐}Ɍ邱Ƃo<a href="#R24"><sup>24)</sup></a>D<sub>2</sub>AhiẽmbNAEg}EX̍ːƎ˂쐶^̃}EXɈړčL}EX쐻CtזEɃ<sub>2</sub>AhiêĂȂ󋵂肾ƂC<sub>2</sub>Ahie̎h̍pقƂǏƂC<sub>2</sub>Ahie̎h̓^ɂ錌tуptɂ郊p̌́CɌtזEɔ<sub>2</sub>Ahiêɂ}邱Ƃ킩<a href="#R24"><sup>24)</sup></a>D
@p̓p߂烊ptւƒEoCpttƍ̂ɂƂȂɂ̂Cӂуp߂ɂǂďzƂőSg߂Ă<a href="#R25"><sup>25)</sup></a>DM҂́C<sub>2</sub>Ahie̎h̓^ɂ胊p߂̃p̒Eo}邱ƂƂ߂<a href="#R24"><sup>24)</sup></a>D̂ƂCtуptɂăp̌錴łƍlꂽDɁCpɂ<sub>2</sub>Ahiê̌C邢́C̃Ahi쓮_ȍɂ胊p߂̃p̒EoiƂC_on̐Iȃx̓͂Cpɔ<sub>2</sub>Ahiêp߂ɃpЂƂǂ߂͂Ă邱Ƃ킩<a href="#R24"><sup>24)</sup></a>D̂ƂC_onזEɓ݂镪q@\ɂ胊p̍ďz𐧌䂷邱ƂŁCp̓Ԃ̍P퐫Ɋ^Ă邱Ƃ炩ɂꂽi<a href="#F3">}3</a>jD̂Ƃ́C_onɂD̓Ԃ̊TYO݂镪q@\ɂ}Ă̂ƑΏƓIł<a href="#R21"><sup>21,22)</sup></a>D

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@_onɂ郊p̓Ԃ̐</strong>
_oñmAhi̓͂C<sub>2</sub>AhiêƃPJCeCCR7CXCR4Ƃ̃NXg[Năp߂ւ̃p̕ێ𑣐i錋ʁCp߂̃p̒Eo}D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/08/Suzuki-4.e011-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2015/08/Suzuki-4.e011-Fig.3.png&amp;caption=fig3-caption-text]


<h2>5D<sub>2</sub>AhiêƃPJCêƂ̃NXg[N</h2>
@pɂ<sub>2</sub>Ahiê̊́Cǂ̂悤ɂăp߂̃p̒Eo}̂낤Dp߂̃p̒Eo̕px́Cp߂̃p̒Eo𑣐iXtBSV1-_e1^VOiƁCp߂ւ̃p̕ێ𑣐iPJCeCCR7CXCR4VOi̋̃oXɂ茈肳<a href="#R25"><sup>25)</sup></a>DM҂́C<sub>2</sub>Ahiê̊ɂƂȂCCR7CXCR4̔IIɑƂCVOi`BñNXg[No<a href="#R24"><sup>24)</sup></a>DɁCpɂCCR7̌邢CXCR4̓ٓIȑjQɂ<sub>2</sub>Ahie̎hɂ郊p߂̃p̒Eo̗}ꂽƂC<sub>2</sub>Ahiê̊ɂƂȂp̓Ԃ̕ωCCR7CXCR4Ɉˑ邱ƂmFꂽ<a href="#R24"><sup>24)</sup></a>D̒mC<sub>2</sub>AhiêCCR7CXCR4Ƃ̃NXg[Np߂ւ̃p̕ێ̃VOi𑝋錋ʁCp߂̃p̒Eo}邱Ƃ炩ɂꂽi<a href="#F3">}3</a>jD
@AhiêƃPJCê͂G^pNêł邪CقȂG^pNêǂ̂`Cê̂ŃVOi`B̃NXg[N̋N邱ƂmĂ<a href="#R26"><sup>26,27)</sup></a>DŁC<sub>2</sub>AhiêƃPJCêƂ̕IȑݍpɂČʁC<sub>2</sub>AhiêCCR7CXCR4ƑIIɕ̂`邱Ƃꂽ<a href="#R24"><sup>24)</sup></a>DM҂́Ĉ̕VOȋp̊ՂɂȂĂC΁C_oñCvbgƉuñAEgvbgɕϊ镪quƂċ@\ĂƍlĂD

<h2>6D_onɂƉuזE̓Ԃ䂳邱Ƃ̈Ӌ`</h2>
@_onƉuזE̓Ԃ̐ɐ[֗^邱ƂꂽC̐IȈӋ`͖炩ł͂ȂDD1̂Őĝ̊ƂƂɌ_on̊܂鎞ԑтɁCt畆ؓȂǖgDɈڍsDŁCM҂̌́C_on̊܂ƃp̓p߂ɂƂǂ܂₷Ȃ邱ƂĂDCӂ̍RٓIɔF郊p̐1̃p߂萔10xƌς邪CꂾȍזȄWcłĂC̋K͂̑傫lƉűɔf邱ƂIɎĂ<a href="#R28"><sup>28)</sup></a>Dĝ̊܂âƑ郊XN܂鎞ԑтɁCâ𒼐ڂɔFĎE邱Ƃ̂łDȂǂ̎RƉuSזEâ̐N̖˂ƂȂ閖gDɔzuCCȂRɓٓIȃplƉũX^[g̏ł郊p߂ɏWς邱Ƃ́CʓIȖƉuUĕâr邤ŗLɂ͂炭ƂDM҂́C_onɂƉuזE̓Ԃ䂳邱Ƃ̈Ӌ`͂ɂƍlĂD́C_ł͉ɂȂČɂ薾炩ɂׂdvȉۑ̂ЂƂłD
@IȃXgX_on̊̍ԂꍇɁClƉun̂ep̓ԂƂϓ_l@Ă݂悤D_on̋ɂƂȂp߂̃p̒EoIɗ}ƁCp߂̂ł̃p̏z܂邽߁Cp߂ɂ郊p̍RِipgAjŒ肳C{͑Sg܂ȂĎׂp̖Ȃ\DC҂ɃXtBSV1-_e1^̋@\IȑjQłtBSh𓊗^ăp߂̃p̒EoIɗ}ԂŖƉu{ꍇɂ́CR̉̏㏸݂Ȃ邱Ƃ񍐂Ă<a href="#R29"><sup>29)</sup></a>D܂CM҂́CƉu{Ƃɂ胊p߂ɂĐGtFN^[TזEɔ<sub>2</sub>AhiêhƁC̃p߂̒Eo}ꖖgDւ̓B܂邱ƂoĂ<a href="#R24"><sup>24)</sup></a>D̂Ƃ́C_onԂł̓GtFN^[TזEp߂犴ʂ邢͎ᇑgDւƈړłCâ邢͎ᇍזErߒɎQłȂƂӖĂD̂悤ɁCIȃXgXɂ_on̎IȋɂƂȂp̓Ԃ̕ω͊lƉu߂ɍpƐ邪Cق̗vlDƂ΁CTזEɑ΂vȍR񎦍זEłזEɔ<sub>2</sub>Ahiêh邱ƂɂCR񎦔\уTCgJCY\ቺ邱ƂmĂ<a href="#R30"><sup>30-33)</sup></a>C_on̊󋵂ł͎זEɂTזE̊Q\D܂CXgXɂ鎋-]-tn̊ɂƂȂt玿番傳R`][ɂƉu}pYĂ͂ȂȂDāC܂߂̋@gXgXɂƉu͂ቺhƂۂɊ^ĂƍlD

<h2></h2>
@100NɂԐ_onɂƉun̐Ɋւ錤̗jɂāC̍זEՂ邢͕qՂ炩ɂȂ͂߂̂͂10NłD̊ԁCɏqׂ̎_onɂƉun̐@\𖾂ꂽDC͂܂e_IłC_onɂƉun̐̑S̑Ղ郌xɂ͒BĂȂD邽߂ɂ́C_onɂƉun̐@\̉𖾂ɐi߂̂͂ł邪CɓIɂ́CCƂ̔]@\ǂ̂悤ȕq@\ɂƉu@\ɉeڂ𖾂炩ɂKvƎvDCM҂ɂĂ͂܂邱Ƃł邪C_ɂāC_onɂƉun̐̌Ɏgł錤҂̂قƂǂ͖ƉuwobNOEhɂĂC̎Œ_onɂ܂ł̂ڂĉ͍͂̂łDāC_onɂƉun̐@\̕Iȗ߂߂ɂ́C_oȊwƂ錤҂ƖƉuwƂ錤҂ƂC_oȊwƖƉuw̗̌nAv[`邱ƂdvłƍlD

<h2> </h2>
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</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author"> ꔎiKazuhiro Suzukij</span>
F2007N ww@wn CCčCaliforniawSan FranciscoZ moāC2011NwƉuwteBAZ^[ CyD
URLF<a href="http://kazuhirosuzuki.com/" target="_blank">http://kazuhirosuzuki.com/</a>
</div>
? 2015  ꔎ Licensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
