GL\\[̌`̉ߒшÂւ̉p

<strong>Wc<sup>1</sup>EJFL<sup>2</sup></strong>
i<sup>1</sup>񌤋Z^[ qזEÌC<sup>2</sup>ȑww qזEÌj
emailF<a href="mailto:nkosaka@ncc.go.jp">Wc</a>C<a href="mailto:tochiya@tokyo-med.ac.jp">JFL</a>
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̈Zr[, <strong>7</strong>, e007 (2018)@<a href="http://dx.doi.org/10.7875/leading.author.7.e007">DOI: 10.7875/leading.author.7.e007</a>
Nobuyoshi Kosaka & Takahiro Ochiya: <strong>Biogenesis and its therapeutic application of exosome.</strong>

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<h2>v </h2>
@GL\\[͍זE番傳鎉dȂ鏬EłD1980NɔĂ猻݂܂ł̑̌ɂCזÊړ܂܂ȕqA邱Ƃ킩ĂĎ`ԓIȓɂC^pN΂łȂCj_CCȂǁC̐q܂ށDזÊ̑ݍpɂāCwIѕawIȋ@\ɒڂ܂ĂCGL\\[WIƂ̐VK̐ff@юÖ@ĂD̃r[ɂẮCGL\\[̗̌jЉƂƂɁCGL\\[̌`ѕ̋@\CƂǂ̂悤Ɋ֌ŴÂɂނ̓W]ɂĘ_D

<h2>͂߂</h2>
@1980Nゲ납C܂܂ȍזEE𕪔傷邱Ƃώ@ĂD̏E͑傫זE̋NɂCexosomeCectosomeCmicrovesicleCshedding vesicleConcosomeCprostasomeȂǁC܂܂Ȗ̂ł΂ꂽDȂČď̂͒`܂łCP@\ɊmĂƂ͂ȂD̂߁CE̍ۓIȌwłInternational Society for Extracellular VesiclesiISEVjł́CזE番傳鏬Ȇ̂Ƃextracellular vesicleiזEOEj̎gp𐄏ĂD
@݁C̒`܂ȍזEOEɌĂD̗RƂāC2DЂƂ́C܂܂ȍזEזEOEɂזÊőݍp邱Ƃł<a href="#R1"><sup>1)</sup></a>DזEɂƂ̂\鑽̎̍זEǂĂ͂炭ƂdvłCזÊ̑ݍpɂ萶̂̋@\͈ێDłɂ݂̑悭mĂzCTCgJCCPJCȂǂ̕^pNזEڒqɂ킦C܂܂Ȑ܂ލזEOȆ݂͑ʂȐۂ̉𖾂̎ƂȂD܂C̍זÊ̑ݍp̔j͎ɂȂD̂߁CזEOÊזÊ̑ݍp̌́C̐VȎÖ@̊JɂȂƍlD
@ЂƂ́CזEOĚ`ԂёݏꏊɂDזEOE̓^pNCj_CCƂ܂܂Ȑ܂ށDɁCt͂߁CtCtCAȂǂ̑̉tɈɑ݂邱ƂĈɂזEOẺ͕͂aԂm肪ƂȂC̐ff@юÖ@ւ̉p҂DɁCזEOE͗RזEɂ肻̍\傫قȂC܂܂ȎɂēIȍזEOȆ݂炩ɂD̂߁C܂ł̍זEgDɑNPIȌւ̗p݂i߂ĂD
@̃r[ɂẮCזEOÊCƂɃGL\\[iexosomejɒڂďЉDGL\\[̗̌j̏ЉČ`ѕ̋@\CāCƂ̊֌WɂāCM҂ɂCɂ錤𒆐SɉD

<h2>1DזEOĚ̗j</h2>
@1983NCdȂ100 nmقǂ̏EԏԌ番傳邱Ƃ<a href="#R2"><sup>2)</sup></a>CGL\\[ƖÂꂽ<a href="#R3"><sup>3)</sup></a>DqcW̐ԌnߒɂāCgXtFê܂ޏE̕傪oꂽ̂łDC̃GL\\[Ƀ^pNςݍݍזE番傷邱Ƃ̈Ӌ`́CזEɂƂsvɂȂ̂ro邱ƂƍlꂽDĈ̖ƉuזEpɂāCGL\\[͋@\Ƃ炩ɂꂽ<a href="#R4"><sup>4)</sup></a>DזEɗRGL\\[̕\ʂɂMHCNXIqMHCNXIIq݂CR̒񎦂\ł邱Ƃꂽ̂ł<a href="#R5"><sup>5)</sup></a>ĎnpVȂ̖ƉuÖ@ƂāCGL\\[pזÊ񃏃N`JCtXɂėՏ{ꂽ<a href="#R6"><sup>6)</sup></a>D܂CGL\\[̔̈ȑOɁCprostasomeƖÂꂽ40`500 nmقǂ̎dȂ鏬E񍐂Ă<a href="#R7"><sup>7)</sup></a>D݂ł́Cprostasome͑OBזE番傳C_ɂ鐸q̕ی삨щ^\̊lɊ^ƍlĂCOBזE傷GL\\[Ɠ`ƍlĂD
@1990Nɂ̓GL\\[͋@\Eł邱ƂĂC͂̋Zp\ɊmĂȂƂCCGL\\[͍זEɂƂsvȂ̂l߂ĊOɎ̂Ă邽߂̃S~܂ƍlĂDC2007NCGL\\[miRNAmRNA܂݁C͍זÊA邱Ƃ炩ɂꂽ<a href="#R8"><sup>8)</sup></a>DɁCM҂܂3̌O[vɂ蓯ɁCGL\\[Ɋ܂܂miRNA͍זÊACAꂽ̍זEɂċ@\邱Ƃ炩ɂꂽ<a href="#R9"><sup>9-11)</sup></a>Dɂ́Ctɑ݂miRNA̐ff@ɗpƂ_\ĂCȍ~CGL\\[Ɋւ_̐IɑD

<h2>2DGL\\[\镪q</h2>
@GL\\[͍זEƋʂ\DdȂCזE^pNזE^pN݂CɁCDNACmRNACmiRNAƂj_܂܂i<a href="#F1">}1</a>jDCזEƃGL\\[Ƃ̂Ŏ̔䗦͈قȂ<a href="#R12"><sup>12)</sup></a>DOBזEłPC3זEɊ܂܂鎉PC3זE番傳ꂽGL\\[Ɋ܂܂鎉͂ʁCGL\\[ɂĂ̓RXe[CXtBSCXtBS~GCzXt@`WZ̊ȂĂD܂CזEɊ܂܂^pNƃGL\\[Ɋ܂܂^pNƂł́C̎ނ䗦ɍقDGL\\[Ɋ܂܂^pN͍זEɂăGL\\[`ߒɂĐςݍ܂邽߁CזEɔĂȂ^pN̓GL\\[ɂ܂܂ȂDCזEɔĂ^pNłCGL\\[ɑIIɐςݍ܂^pNѐςݍ܂Ȃ^pN݂CC^pÑGL\\[ւ̑IIȐςݍ݂݂̑炩ɂĂDM҂́CGL\\[Ɋ܂܂^pNCƂɃGL\\[̃}[J[ƂĂ11ނ̃^pN̔9ނ̍זEɂăEFX^ubg@ɂ͂<a href="#R13"><sup>13)</sup></a>DPʃ^pNʂ̊ܗLʂזEƃGL\\[ƂŔrƂC͂9ނ̍זEׂĂɂCD9CD81̓GL\\[ɔZkĂD܂CAN`̓GL\\[ɔ׍זÊقɑ܂܂ꂽDɁCᕪqGTPasełRab5b⎉tg̃}[J[łFlotillin-1́CזEɂĂ̓GL\\[ɔZkĂCGL\\[ɂ͂قƂǊ܂܂ȂזED̂悤ɁCזEɂ^pÑvt@CׂăGL\\[ɔf킯ł͂ȂD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@GL\\[ɑ݂\Iȕq</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2018/08/Ochiya-7.e007-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2018/08/Ochiya-7.e007-Fig.1.png&amp;caption=fig1-caption-text]

@GL\\[̔܂ŁCזÊ̊j_̗AɊւ񍐂́Cꕔ̓ȗ܂ȂDƂ΁CA|g[VXNזE番傳A|g[VX̂ɂDNA̒fЂ܂܂ĂCق̍זEɈړ邱Ƃ񍐂Ă<a href="#R14"><sup>14,15)</sup></a>D̂̂CESזEɗRGL\\[mRNA܂܂COזEւƗA邱Ƃ炩ɂꂽ<a href="#R16"><sup>16)</sup></a>DāC2007NCGL\\[miRNA܂܂邱ƂCGL\\[̌̃uCNX[ƂȂ<a href="#R8"><sup>8)</sup></a>DmiRNÁC1993NCɂĕWIƂȂmRNA3f|̈Ɍ|}邱Ƃ񍐂Ĉ̂CMɂĂmiRNAāC݁CqgɂĂ2000ވȏmiRNȂ݂炩ɂĂD1ނmiRNA̎ނmRNA̔𐧌䂷邱ƂCmiRNAזEɂ`q̐ɏdvȕqł邱Ƃ͖łD䂦CmiRNA܂ރGL\\[傳邱Ƃɂ͑傫ȃCpNgD̃GL\\[ɂmiRNA̔̂̂CGL\\[Ɋ܂܂miRNA͎͂̍זEւƗÂCāCAꂽ̍זEɂĂǂ̂悤Ȗ̂̏œ_ɂȂDɂqׂ悤ɁCM҂܂3̌O[vɂ蓯ɁCGL\\[Ɋ܂܂miRNA̋@\̉͂ɂ񍐂ꂽ<a href="#R9"><sup>9-11)</sup></a>DmiRNAGL\\[ɂזÊA邱Ƃ炩ɂꂽ̂łD

<h2>3DGL\\[̌`ѕ̋@\</h2>
@GL\\[́CGh\[ɗRזE番傳鏬Eƒ`ÂĂDGL\\[̌`́CGhTCg[VXɂזEɑ݂ê܂݂Ȃ珉Gh\[`Ƃ납͂܂DÂāCGh\[͌Gh\[ւƈڍsČGh\[ɂтčoEiintraluminal membrane vesicleFILVj`D̂̂CoE𑽂܂ޑEGh\[imultivesicular bodyFMVBjזEƗZCזEoD̍זE番傳ꂽEGL\\[Ƃԁi<a href="#F2">}2</a>jDȉCGL\\[̌`ѕɂ镪qɂĉ<a href="#R17"><sup>17)</sup></a>D

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@GL\\[`ߒ̊T</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2018/08/Ochiya-7.e007-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2018/08/Ochiya-7.e007-Fig.2.png&amp;caption=fig2-caption-text]

@GL\\[̌`ɂ́CESCRTiendosomal sorting complex required for transportjɈˑIȌoHƔˑIȌoHƂ݂i<a href="#F3">}3</a>jDESCRTɈˑIȌoH́CESCRT-0́CESCRT-ÍCESCRT-IÍCESCRT-IIÎ4ނ̃^pŃCсCƌ^pN\DESCRT-0̂rL`ɈˑIɃ^pNN[gCESCRT-ÎESCRT-IÎɂ菬Eo肵CESCRT-IIÎɂ菬E͕D܂CATPasełVPS4E̕уTCNOɂDɁCזEɗRGL\\[ɂESCRT̂ƌ^pNƂTSG101ALIX݂DTSG101̔}邱ƂɂGL\\[̕傪}DESCRT-0̂̍\^pNłHRSGL\\[̕ɕKvłDESCRT-3̂ƌALIX͍ǒ`𑣐iD̃^pNׂĂ{ɃGL\\[̌`ɂ邩ǂ͍זEɂقȂƍlĂD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@GL\\[̌`ɂ镪q</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2018/08/Ochiya-7.e007-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2018/08/Ochiya-7.e007-Fig.3.png&amp;caption=fig3-caption-text]

@ESCRTɔˑIȌoH݂DƂ΁CISfhOAזEɂẮCESCRTɈˑIȌoHjQĂGL\\[傳D̂ƂCXtBS̈łZ~hY钆XtBS~Gi[[jQ邱ƂɂGL\\[͑̕jQꂽ<a href="#R18"><sup>18)</sup></a>D܂CEGh\[̏dvȍ\łRXe[̒~ςɂGL\\[͑̕iꂽD܂CזE4ђʂ\^pÑt@~[łegXpjɂāCCD9CCD63CCD81GL\\[ւ̃^pN̐ςݍ݂ɂDۂɁCegXpj͑EGh\[ɂčoEɑ݂CegXpĵЂƂłTSPAN8CD81̓GL\\[ւ̃^pN̐ςݍ݂ɂD܂CqVyESCRTɔˑIɃGL\\[̕ɂCHSC70̓gXtFêƂ̃^pNoEɎ荞܂D畡̋@\݂̑́CЂƂ̍זEɂĈقȂނ̑̕EGh\[݂̑肷邱ƂɂDŋ߂̃GL\\[̏ڍׂȕуveI[͂ɂCGL\\[ɂ͕sώ݂̑邱ƂĊmFꂽD܂CƉuזEтזEɂāC̃weȃGL\\[ꂼقȂ@\ƂꂽDGL\\[̕sώӎC̋@\𖾂邱Ƃdvł낤D
@GL\\[̕ɂ^pNƂRABt@~[DᕪqGTPasełRABt@~[́CĚ`CזEiɂIKl̈ړCWIƂȂ镔ʂւ̌CזEւ̗ZȂǁCזEł̏EAɂĒSIȖSDGL\\[̉̕ߒɂ́CRAB11 <a href="#R19"><sup>19)</sup></a> RAB35 <a href="#R20"><sup>20)</sup></a> D܂CHeLaזEɂRABt@~[̃XN[jOɂCRAB27ARAB27BGL\\[̕ɂ邱Ƃ炩ɂꂽDCRAB11ARAB7̔}ĂGL\\[͌̕Ȃ<a href="#R21"><sup>21)</sup></a>DRAB27AɂGL\\[̑̕íCm[}CCG炪ɂĂmFĂCꂼC̈ɂ邱ƂĂDCזEłMCFזE番傳VejALIX܂ރGL\\[RAB7ɂ萧䂳DRABt@~[͑EGh\[̍זEւ̌ɂƍlĂ邪CۂɁCǂ̃^pNGL\\[̕ɂɂĂ͍זEɂقȂƍlĂDŁCRABt@~[ɂẮCق̋@\ɂĂlKvDƂ΁C}EXזEł4T1זEɂẮCRAB27A̔}邱ƂɂMMP9̕傪}<a href="#R22"><sup>22)</sup></a>D܂ClȌۂm[}זEɂPLGF2CPDGF-ACIXeI|`ɂĂ񍐂Ă<a href="#R23"><sup>23)</sup></a>DƂƁCGh\[oH͍זEO^pN𕪔傷@\ƂĒmĂDGL\\[C̕^pNƓ悤ɍזÊ̑ݍpS߁Cɕ傳邱Ƃ͎RȂƂł͂邪CɂĂ͗ӂKvD
@GL\\[̌`𐧌䂷^pNɂĂ̕񍐂D}`qYłp53́C<em>p53</em>`q̉`qł<em>TSAP6</em>`qăGL\\[̕ɂ<a href="#R24"><sup>24)</sup></a>DۂɁCTSAP6mbNAEg}EX̓GL\\[̌̕ɂזEɃgXtFê~ςCُɐnԏԌ邽ߏԌn̏Ǐ悷<a href="#R25"><sup>25)</sup></a>Dp53̉ɃGL\\[̕傪邱Ƃ́CGL\\[̕傪wIɐ䂳ĂЂƂ̏؋ƂD

<h2>4D̈ɂGL\\[̖</h2>
@GL\\[Ɋ܂܂miRNAזÊA邱Ƃ񍐂ĈȗCGL\\[̌ɂȂDƂɁCGL\\[̕ʂ|{eՂȂ̌ɂāCGL\\[ɂ񍐂DƉuCz펾C_oƁC̎ɂăGL\\[̏dvĂ邪C̃r[ɂẮCƂɂ̌ɂĉ
@ɑ􂷂邪זEɂƂCh{lÂ邱Ƃ͐ɕK{łCזE͎ᇂɌǂV邱Ƃɂ葽̉h{lĂDM҂́CזE番傳GL\\[ᇂɌǂV邱Ƃ𖾂炩ɂ<a href="#R26"><sup>26)</sup></a>DזẼGL\\[̕}邱Ƃɂ茌ǂ͐VȂȂCʓIɁC̓]ڂ͗}ꂽDCזE͖ƉuזE˂ɂ܂Â邱Ƃɂ萶邪CזE^ɔri`L[זÉCזE番傳GL\\[ɂ芈ɕKvNKG2D̔}ČʁCזE͖Ɖu@\̂Ă<a href="#R27"><sup>27)</sup></a>D܂CזE番傳GL\\[͐ȐۉזEɍpCɊ֘AۉזEւƕ<a href="#R28"><sup>28)</sup></a>D
@͐isƕɂ񂪍L镠d킪邱Ƃɂ莡ÂɂȂD̕dɂĂ͂܂܂ȕq@\񏥂Ă邪CזE番傳GL\\[vDɂĂזE番傳ꂽGL\\[͕̒זEɎ荞܂A|g[VXЂNDɂ蕠Ɍ󂫁CזE̕d킪ƍl<a href="#R29"><sup>29)</sup></a>D悤ɎÂ̍Ȃ̓]ڂƂāC]ւ̓]ڂD]ɂ͌t]֖Ƃ΂ǂ݂Ch{f̂ق̔̕]ւ̎RȈړ͐ĂDCזE͂̏ǂ˔j]ڂ𐬗D̋@\ɂGL\\[DM҂́C]ɓ]ڐ̓זEpāCGL\\[t]֖`זÊЂƂł錌ǓזE̍\ωCԂ邱Ƃ肪̓]ڂ𐬗邱Ƃ𖾂炩ɂ<a href="#R30"><sup>30)</sup></a>D
@͍ĔXN5N`10Nƒɂ킽邱ƂmĂD̃f̂ЂƂƂāCזEɐNԂ̋xɓƂ@\񏥂ĂDM҂́C̊ԗtnזẼGL\\[זE̋x𑣐i邱Ƃ𖾂炩ɂ<a href="#R31"><sup>31)</sup></a>D
@זE]ڂ܂ɁC]ڂ̑ɍpזE₷悤Ȋ𐮔Ƃseed and soilC̍ۂɐ̂ƂO]ڃjb`ƂԁD̑傫Ȗ_ł]ڂ̗}lƂCseed and soil̕q@\̉𖾂͔ɏdvłDŋ߁CGL\\[̑O]ڃjb`̌`ɂ邱Ƃ񍐂ꂽDm[}͔xւƓ]ڂ₷C]ڐ̃m[}זEɗRGL\\[}EXɓ^ƁCO]ڃjb`̌`̏iǨۂƍlĂxɂ錌ǓזE̓ߐiꂽD̂ƂCO]ڃjb`̌`ɂ鑽̈`q̔㏸ĂDɁC}EXɃm[}ɗRGL\\[𓊗^̂m[}זEڐAƁCm[}̓]ڂiꂽD̂ƂCm[}זEɗRGL\\[̍זEɍpC̍̍זE]ڑłxւƈړO]ڃjb``Ă<a href="#R23"><sup>23)</sup></a>Dł́CȂ̃GL\\[͓̍זE邢͑Ɉړ̂낤DɊւāCGL\\[ɑ݂CeO̔p^[̈ႢɂGL\\[荞ލזEςCʓIɁC̓ٓIȑO]ڃjb`̌`i邱Ƃoꂽ<a href="#R32"><sup>32)</sup></a>D

<h2>5DזEɗRGL\\[WIƂ̎</h2>
@܂ł̌ɂCזEɗRGL\\[̕jQ邱ƂɂC̓]ڂ͗}邱Ƃ킩Ă<a href="#R33"><sup>33)</sup></a>DGL\\[̗̕}͔ɖ͓IȃAv[`ł邪CזEȊO̍זEGL\\[𕪔債܂܂Ȑpɂ邱ƂC܂Ƃ߂ė}邱Ƃ́Cvʕp\TdɂȂKvD̂߁CזEƂɓٓIȃGL\\[̋̕@\𖾂炩ɂCWIƂÖ@mKvDGL\\[̋̕@\ɂĂ͂܂sĂł邪CזE͐ȍזEƔ׃GL\\[̕ʂ炩ɑD̂ƂCזEɂGL\\[̋̕@\͐ȍזEƂ͈قȂƍlD̂߁CזEɂGL\\[̕ɂ镪q𓯒肵WIƂ邱ƂC̃Av[`ɂ鎡Â̎ɂނɂȂD
@זE番傳ꂽGL\\[͌tzDŁČtɑ݂邪זEɗRGL\\[@ĂĂDM҂́CqĝזE}EXɈڐACGL\\[ɑ݂qgCD63邢̓qgCD9WIƂR̂𓊗^ƂCזE̓]ڂLӂɗ}ꂽ<a href="#R34"><sup>34)</sup></a>D̂ƂCזEɓٓIȃGL\\[̍RWIɂ̂ł͂ȂCCD63CD9͂זÊ݂Ȃ炸ȍזEɗRGL\\[ɂ݂DȍזE番傳GL\\[jQƏdĂȕp̐邱Ƃl邽߁Cۂ̗Տ̌ɂčRCD63R̂RCD9R͎̂gpłȂDČ̓WJɂCזEɗRGL\\[ɓٓIɑ݂R肳΁C̃Av[`͔ɗLł낤D

<h2>6DGL\\[p̐ff@̊J</h2>
@GL\\[̓qg̑̉t̂قڂׂĂɌo邱ƂCoCI}[J[ƂĂڂĂD̂̂قƂǂ̍זE̓GL\\[𕪔債ĂC傳ꂽGL\\[͎͂̍זEɎ荞܂̂΁C̉tz̂DGL\\[זẼoCI}[J[Ƃėp邽߂ɂ́C܂܂ȍזE番傳ꂽGL\\[̂ȂCזE債GL\\[ٓIɌo肷邱ƂKvɂȂD݁CGL\\[̌oɂ́CS@ɂGL\\[̂EFX^ubg@Ȃǂ{sKvDɁC̎Ȃǂ̚G܂܂鎎ɂĂ̓GL\\[̏x߂鐸@KvƂȂDߔNł̓t[TCg[^[po@JĂ邪C̏ꍇGL\\[𐸐KvC܂CGL\\[̂悤ȐSnm̔q͑肪ނߗՏɂ͕słD
@M҂́C̎璼ڂZԂő̂̃GL\\[o@̊JɎg݁CExoScreen@lĂ<a href="#R35"><sup>35)</sup></a>D̕@́CGL\\[ɑ݂^pNقȂC2ނ̃mN[iR̂ɂ͂ݍ݁C2ނ̍R̂200 nmȓɋߐڂꍇ̂݌uVOiGL\\[̌o\ɂȂ̂łDɁCזEɗRGL\\[݂̂o邽߁CזEɗRGL\\[ɓٓI邢͑ʂɊ܂܂镨WIƂCGL\\[̌`𑹂Ȃ킸Ɍo邱ƂlDExoScreen@p邱ƂɂCȕւvɑ̂̏\łDۂɁC̕@pāCזE|{̏㐴Ɋ܂܂GL\\[CсCɊ܂܂GL\\[̏Ԃ猟oꂽDɁCזEɗRGL\\[o邽߁CזE傷GL\\[ɓٓIɑ݂^pN𓯒肵C݁CɊ܂܂邪זEɗRGL\\[̌o݂ĂD
@ڍׂ͏qׂȂCGL\\[Ɋ܂܂miRNAoCI}[J[ƂĒڂĂCtɕ傳ꂽmiRNA̐ffւ̗Lp񍐂ĂD

<h2></h2>
@GL\\[̔30N߂o߂݁Č҂GL\\[̂炷܂܂ȐۂɋЂꌤɎg݂͂߂D܂CGL\\[ɂVK̎Ö@VȃoCI}[J[ƂĂ̗pɊ҂܂ĂCՏւ̉pւނs낪i߂ĂDCƂ΁CGL\\[̋̕@\ɂ͕̌oĤ݂CGL\\[ɂ͂ǂ̂悤Ƀ^pNmiRNA荞܂̂ȂǁCsȓ_DɁCAꂽ̍זEւ̎荞݂̋@\ɂĂsȓ_C̍ۂɂ镪qwȂǁCڍׂ𗝉邱Ƃ̂Ȃ锭WɏdvłDGL\\[͕̕qȂ镡̂łC܂CזEזÊĂɂ蕪傳GL\\[ςDGL\\[̒P@ɊւĂKvƂĂDGL\\[̊bIȌ́C̐VȐff@юÖ@ɂȂD܂ĈقɂC_oz펾ȂǁC̎ɂăGL\\[݂̑dvĂD̎ɂĂVȐff@юÖ@̊J҂ĂD

<h2> </h2>
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</ol>
<div class="au-profile">
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<span class="author"> WciNobuyoshi Kosakaj</span>
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