튯̃TCY𐧌䂷Hippo-YAP/TAZVOi`BoH

<strong>{EmȔj</strong>
iȎȑw Đwj
emailF<a href="mailto:miyamura.dbio@mri.tmd.ac.jp">{</a>C<a href="mailto:nishina.dbio@mri.tmd.ac.jp">mȔj</a>
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̈Zr[, <strong>5</strong>, e004 (2016)@<a href="http://dx.doi.org/10.7875/leading.author.5.e004">DOI: 10.7875/leading.author.5.e004</a>
Norio Miyamura & Hiroshi Nishina: <strong>Organ size regulation by Hippo-YAP/TAZ signaling pathway.</strong>

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<h2>v </h2>
@̂튯̃TCYǂ̂悤ɐ䂳Ă̂͂Ȃ炭słCߔNC̕qԂ炩ɂD̂̃TCY͍`ɂ萧䂳C`̐͐zуCXlqɂSDC튯̃TCY͍זE̐ё傫ɂ萧䂳DߔNCHippo-YAP/TAZVOi`BoHזE̐𐧌䂷邱ƂɂC튯̃TCY̐ɂĒSIȖSƂꂽD܂CHippo-YAP/TAZVOi`BoH͂̔ǂ∫ɂ[֗^邱ƂĂDɁCHippo-YAP/TAZVOi`BoH͊튯3̍\z𐧌䂷邱Ƃ炩ɂD̃r[ł́Czɂ̂̃TCY̐@\CсCHippo-YAP/TAZVOi`BoHɂ튯̃TCY̐@\ɂĉD

<h2>͂߂</h2>
@nɂ͑푽lȐ݂C̑̂̃TCY͂܂܂łDMł́C̒cm̃}EXC2 m̃qgC\m̃NWȂǂ݂i<a href="#F1">}1a</a>jDCkł͏^Ƒ^Ƃő̒i̍j{قȂi<a href="#F1">}1b</a>jD̂̃TCY̐ɂ́CzуCXlqɂ鍜`dvȖSƂĂD܂CM̊튯ɂāC̑0.033~̏d<sup>0.87</sup>CS0.006~̏d<sup>0.98</sup>C]0.011~̏d<sup>0.76</sup>̊֌Wɂ邱Ƃ񍐂Ă<a href="#R1"><sup>1)</sup></a>D̂悤ɁC튯̃TCŶ̃TCYɑ΂܂Ɍ`邢͈ێ邵݂݂̑DȂC݂ǂ̂悤ȕq@\ɂSĂ邩͕słDC튯̃TCY͊튯\זE̐ё傫ɂ茈肳DߔNC튯̃TCY𐧌䂷VOi`BoĤЂƂƂāCזE̐̐SHippo-YAP/TAZVOi`BoH肳ꂽ<a href="#R2"><sup>2)</sup></a>DHippo-YAP/TAZVOi`BoH̓VEWEoG}EXCqgɂ܂ŕۑĂC튯̃TCY̐ɂĒSIȖSƂĂD܂C튯̃TCY̐̔j]ɂ肪𔭏ǂ邱ƂĂCHippo-YAP/TAZVOi`BoHƔƂ̊֘AڂĂD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@̑̂̃TCY̔r</strong>
iajqgƃNW̑̒D
ibj^i`jƑ^iO[gEf[j̑̍i<em>Science</em>, <strong>316</strong>, Iss.5821 (2007) ̕\QlɂjD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/04/Nishina-5.e004-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2016/04/Nishina-5.e004-Fig.1.png&amp;caption=fig1-caption-text]


<h2>1D̂̃TCY̐</h2>
@1909NCCk̉̂؏邱Ƃɂ̂̃TCYቺ邱ƂC𑣐iq̂ɑ݂邱Ƃꂽ<a href="#R3"><sup>3)</sup></a>D1920Nɂ́Ĉ番傳^pN̒PѐɂCz肳ꂽi<a href="#F2">}2</a>jDz͎o2ނ̃zɂ肻̔䂳<a href="#R4"><sup>4)</sup></a>DЂƂ͐zozłCz̕𑣐iDЂƂ̓\}gX^`łCz̕}Dz͍[̍זEɍpC`𑣐i̒𑝉D܂Cz̓^ɂ茌ɕ傳^pNC\}gWƖꂽD͂̌ʁC\}gWAу\}gWĆCꂼCCXlqIIуCXlqIƓ肳ꂽDCXlq͂̎êPI3K-mTORVOi`BoHCԗtnזE̍זEւ̕UC`𑣐iđ̒𑝉<a href="#R3"><sup>3,4)</sup></a>D

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@zуCXlqɂ̒̐</strong>
番傳鐬zzу\}gX^`́Ĉɍpz̕𐧌䂷Dzz͕𑣐iC\}gX^`͕}Dz͊̑Ȃǂ̖gD̍זEɍpCCXlq̕𑣐iDzуCXlq͍`𑣐i̒𑝉D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/04/Nishina-5.e004-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2016/04/Nishina-5.e004-Fig.2.png&amp;caption=fig2-caption-text]

@zCXlq̑̂̃TCYւ̉eɂāC̗Ⴊ񍐂ĂD1982NCzߏɔgXWFjbN}EXoꂽ<a href="#R5"><sup>5)</sup></a>D̃}EX̑̏d̖͐2{܂őCX[p[}EXƖÂꂽD̂̔ɂ<em>Prop1</em>`qmbNAEg}EX̑̏d́Cz̔̒ቺɂ萳̖50܂Ō<a href="#R6"><sup>6)</sup></a>DzễmbNAEg}EXCCXlqI̊̑ɓٓIȃmbNAEg}EXC50̑̏dɂȂ<a href="#R5"><sup>5)</sup></a>DCXlq̑̂̃TCYւ̉éC^я^p`Iȉ͂ɂĂꂽ<a href="#R7"><sup>7)</sup></a>D^Ə^Ƃ̂ŃCXlqIR[h`q1^isingle nucleotide polymorphismFSNPjoꂽD1^ɂC^ł̓CXlqI̕ʂ͑^̖񔼕܂ŌC`͒ቺ̒͌D̑^͒{Y̕ɂĊ֐SDߔNCzߏɔgXWFjbNu^́C̑x̘iі10̑̏d̑Ƃ񍐂ꂽ<a href="#R8"><sup>8)</sup></a>D
@܂Cz̓qgɂďlǂ⋐lǂ̔ǂɂ֗^<a href="#R5"><sup>5)</sup></a>Dlǂ̈ł鐬zsSgǂ́Cz̒̕ቺɂ鍜`̒ቺƂĔǂDlǂ͐z̉ߏȕɂglȂǂɐُ̈NƂŔǂD̎ɂẮCOȓIȐ؏򕨂̓^ɂ鎡ÂmĂDł1956Nɂ́Clǂ̎ÂɐzLł邱ƂؖĂC60N܂ՏɉpꂽjDߔNClǂɂĂ̓\}gX^`Û␬zê̝hR𓊗^鎡ÂsĂD

<h2>2DHippo-YAP/TAZVOi`BoHɂ튯̃TCY̐</h2>
@1990NC<em>p53</em>`q<em>Rb</em>`qɂVȂ}`qT邽߁CVEWEoG̃UCN͖@p`wIȃXN[jOsꂽ<a href="#R9"><sup>9,10)</sup></a>ĎʁC<em>Hippo</em>`q܂ޕ̂}`qN[jOC2003NC}VOi`BoHƂHippoVOi`BoHꂽi<a href="#F3">}3a</a>jD̂̂CHippoVOi`BoH̕WIƂȂ^pNƂē]ʋqłYki肳CYkiƓ]ʈqƂ̂̕זȆBזEɊ֗^`q̓]ʂ𐧌䂷邱Ƃ炩ɂꂽDVEWEoG̕ɂHippoVOi`BoHj]YkiC̉ߌ`̔傪ώ@ꂽD̂̉͂ɂCHippo-YkiVOi`BoH͍זE̐𐧌䂷邱Ƃɂ튯̃TCY𐧌䂷邱ƂꂽD2007Nȍ~CHippo-YkiVOi`BoH͚MɂĂxɕۑĂ邱Ƃꂽ<a href="#R9"><sup>9)</sup></a>i<a href="#F3">}3b</a>jDVEWEoG<em>Hippo</em>`q͚M<em>Mst1</em>`q<em>Mst2</em>`q̑`qłD<em>Warts</em>`q<em>Lats1</em>`q<em>Lats2</em>`q́C<em>Mats</em>`q<em>Mob1a</em>`q<em>Mob1b</em>`q́C<em>Yki</em>`q<em>YAP</em>`qт̃pOł<em>TAZ</em>`q̑`qłD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@Hippo-YAP/TAZVOi`BoH̍\^pN</strong>
iajVEWEoGɂHippo-YkiVOi`BoHDHippooH́CZXIjLi[[łHippoWartsCсC^pNłSavMats4ނ̎vȃ^pNɂ\DWarts̊ɂYki̓_C_^Yki14-3-3ƌזEɋǍ݂DE_^Yki͊jւƈڍsC]ʈqSdƌ`q̔𐧌䂷DEx-Merlin-KibrâHippoD
ibjMɂHippo-YAP/TAZVOi`BoHDHippoMst1/2ƁCWartsLats1/2ƁCMatsMob1a/1bƁCYkiYAP/TAZƁCSdTEADƁCꂼΉD_ꂽYAP/TAŹC14-3-3Ƃ̌ɂ킦CɓD
PF_D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/04/Nishina-5.e004-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2016/04/Nishina-5.e004-Fig.3.png&amp;caption=fig3-caption-text]

@2007NCYAPhLVTCNɈˑĊ̑ɂĉߏɔgXWFjbN}EXoꂽ<a href="#R2"><sup>2,9)</sup></a>Dȃ}EX̊̑̃TCY͑̏d̖5ł邪C̃gXWFjbN}EX̊̑̃TCÝChLVTCN̓^̂̂4TԂ܂łɖ5{ɑ債D[ƂɁC8TڂɃhLVTCN̓^𒆎~ƁC~̂̂2TԂ܂łɊ̑͂Ƃ̃TCYɂǂD̑̃TCỶtIȐ䂩CYAP͚Mɂ튯̃TCY̐ɂĒSIȖSƂꂽD܂CHippo-YAP/TAZVOi`BoH̍\^pÑmbNAEg}EXɂĂC̑̃TCY̑傪񍐂Ă<a href="#R2"><sup>2,9)</sup></a>DMst1Mst2̊̑ɓٓIȃ_umbNAEg}EX̊̑̃TCY͐2JŖ5{ɁCMob1aMob1b̊̑ɓٓIȃ_umbNAEg}EX̊̑̃TCY͐14Ŗ4{ɁCSav1̊̑ɓٓIȃmbNAEg}EX̊̑̃TCY͐4`6JŖ1.5{ɑ債D܂C<em>Nf2</em>`qR[hMerlin̊̑ɓٓIȃmbNAEg}EX̊̑̃TCY͖5{܂ő債CYAP邱Ƃɂ肱̑͗}ꂽĎʂCMerliňɂ̑̑YAP䂳邱ƂꂽD̑̂قCC畆CSȂǂ̑gDɂĂCHippo-YAP/TAZVOi`BoH튯̃TCY𐧌䂷邱ƂĂ<a href="#R2"><sup>2)</sup></a>D

<h2>3D̑̃TCY𐧌䂷VOi`BoH</h2>
@̂قɂC̑̃TCY̑gXWFjbN}EXmbNAEg}EX񍐂ĂD]ʋqJej̃gXWFjbN}EXCJej̕ɂAPC̃mbNAEg}EX̊̑̃TCY2`3{ɑ債<a href="#R11"><sup>11)</sup></a>DᕪqG^pNRas̊^ψّ̂̃gXWFjbN}EXCсC_yfAkt̊^ψّ̂̃gXWFjbN}EX̊̑̃TCY2`3{<a href="#R12"><sup>12,13)</sup></a>CzXt@`WCmVg[gX_̒E_G}yfPTEN̊̑ɓٓIȃmbNAEg}EX̊̑̃TCY2`3{<a href="#R11"><sup>11)</sup></a>CזEڒɊ֗^CeO̊֘A^pNILK̊̑ɓٓIȃmbNAEg}EX̊̑̃TCY͖2.5{<a href="#R14"><sup>14)</sup></a>CI[gt@S\[̍\^pNłAtg7̃mbNAEg}EX̊̑̃TCY2`4{ɑ債<a href="#R15"><sup>15)</sup></a>DC̍זȆBɏdvłHGF̃gXWFjbN}EXCсCזE𐧌䂷TCND1̃gXWFjbN}EX̊̑̃TCY̑́CꂼC1.1{CсC1.5{ł<a href="#R11"><sup>11,16)</sup></a>D[ƂɁCWnt-JejVOi`BoHAkt-mTORVOi`BoH́CHippo-YAP/TAZVOi`BoHƃNXg[N邱Ƃ炩ɂ<a href="#R17"><sup>17,18)</sup></a>D̒mCWnt-JejVOi`BoH邢Akt-mTORVOi`BoH̕ψقɂ̑̃TCY̑́CHippo-YAP/TAZVOi`BoH\ꂽD

<h2>4D튯̃TCY̑Ɣ</h2>
@ɏqׂ̑̃TCY̑}EX̑́C𔭏ǂDhLVTCNɈˑYAPߏɔgXWFjbN}EX́C2Jȏɂ킽YAP̊Ɗ̍זE𔭏ǂ<a href="#R2"><sup>2,9)</sup></a>DMst1Mst2̊̑ɓٓIȃ_umbNAEg}EX͐3JŊ̍זE𔭏ǂ<a href="#R2"><sup>2,9)</sup></a>DMob1aMob1b̊̑ɓٓIȃ_umbNAEg}EX͐4JŁCSav1̊̑ɓٓIȃmbNAEg}EX͐8JŁCMerlin̊̑ɓٓIȃmbNAEg}EX͐6JŁC̍זEƒ_ǏזE̍𔭏ǂ<a href="#R2"><sup>2,9)</sup></a>DApc̊̑ɓٓIȃmbNAEg}EX͐8J<a href="#R11"><sup>11)</sup></a>CPTEN̊̑ɓٓIȃmbNAEg}EX͐10J<a href="#R11"><sup>11)</sup></a>CAtg7̃mbNAEg}EX͐7J<a href="#R15"><sup>15)</sup></a>CTCND1̃gXWFjbN}EX͐17JŁC̍זE𔭏ǂ<a href="#R16"><sup>16)</sup></a>D
@qĝgDɂāC<em>PTEN</em>`q<em>Apc</em>`q̌Ă邱Ƃ񍐂Ă<a href="#R19"><sup>19,20)</sup></a>D܂ߔNCqĝgDɂāCYAPTAZ̍jւ̋Ǎ݂̘i炩ɂĂ<a href="#R9"><sup>9,21)</sup></a>DɁCYAPTAZ̍jւ̋Ǎ݂́C̗\̕sǂɑւ邱ƂĂDƂ΁CYAP͊̂̊҂̖60C񏬍זEx̊҂̖60C݂̊҂̖30C̊҂̖15CTAZ͊̂̊҂̖50ŁCjւ̋Ǎ݁CсC\̕sǂĂ<a href="#R9"><sup>9)</sup></a>DȂCqĝgDɂāCMstLats̔̒ቺs݂͂̂́C̈`q̕ψق͂܂萶ĂȂ<a href="#R9"><sup>9)</sup></a>DqĝgDɂYAPTAZ̍jւ̋Ǎ݂Cǂ̂悤ȋ@\ɂЂNĂ邩ɂĂ͕sȓ_D

<h2>5DYAP/TAZ̊𐧌䂷זEOVOi</h2>
@ȍזE̓̂ЂƂƂāCזEǂ̐ڐGɂȂƑB~זEڐGjQmĂD̕q@\ƂāCזE̐ڐGɂYAP/TAZsCזȆB~邱ƂĂ<a href="#R22"><sup>22)</sup></a>D܂Cqg̏זEpɂCYAP/TAZ̊̏ԂזEO̍dxזĚ`Ԃɉω邱Ƃ炩ɂꂽ<a href="#R22"><sup>22)</sup></a>DזEdזEO̂ɑ݂ꍇCזELĂĂ̖ʐςLꍇɂ́CYAP/TAZ͊jɋǍ݂Ĉ`q̔UCזE͑BDCזE_炩זEO̂ɑ݂ꍇCזEkłĂ̖ʐςꍇɂ́CYAP/TAZ͍זEɋǍ݂CזE͑B~ĎʂCYAP/TAZזEO̃VOĩGtFN^[Ƃċ@\CזẺ𐧌䂷邱ƂꂽDזEO̍dx̃VOi͍זEiłAN`ۂYAP/TAZɓ`BƍlĂ<a href="#R22"><sup>22)</sup></a>DAN`ۂYAP/TAZ̊ɂ镪q@\ƂẮCLatsɈˑIȋ@\єˑIȋ@\񍐂ĂD

<h2>6D3̊튯̍\z𐧌䂷YAP</h2>
@튯3IȍזE̍\zKvƂ邪C3̊튯̍\z𐧌䂷镪q@\ɂĂ͕sȓ_DM҂́C튯̌`@\Ɋ֗^Vȃ^pNT邽߁C_JpK͂ȕψّ̂̃XN[jOs<a href="#R23"><sup>23)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/9945" target="_blank">V_r[</a> łfځjĎʁC3̑gD̍\Ƃꂸɑ̂G<em>hirame</em>i<em>hir</em>jψّ̂̒Pɐi<a href="#F4">}4a</a>jD|WViN[jǑʁCYAPR[h`qɂψقł邱ƂD͂𑪒肵ʁCזE͂ቺĂ邱ƁCANg~IVlbg[N̊̐YAPSƂoꂽD܂CPזẼxł̃^CvX͂C<em>hir</em>ψّ̂ł͍זEُ͂̈ɂזEd͂ɍRւƐςݏオ炸C_oǂȂǂ̏gDG邱ƂoꂽDɁCYAP̓AN`̏d̐ătBulN`Ȃǂ̍זEO̍ĕҐЂNC̃YіԖ̐ȑgD̔zuɊ֗^邱Ƃ炩ɂꂽDȂ킿CזEOȂǍזEÕVOiYAP̊ЂNCYAP̓AN`̏d}CזEOĕҐi<a href="#F4">}4b</a>jDYAPtB[hobN̋@\݂̑ɂCזE͎炨ꂽOmK邱ƂłƍlD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@YAPɂ3̊튯̍\z̐</strong>
iaj쐶^̃_JCсCYAP<em>hir</em>ψّ́D<em>hir</em>ψّ̂͏d͂ɍRƂłGɂȂD
ibjYAPזEO̐@\DזEOȂǍזEO̃VOíCAN`̏d𑣐iYAPDYAṔCARHGAP18ăAN`̏d}DAN`̏d̓tBulN`Ȃǂ̍זEO̍ĕҐЂNCזEO𐧌䂷D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/04/Nishina-5.e004-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2016/04/Nishina-5.e004-Fig.4.png&amp;caption=fig4-caption-text]


<h2></h2>
@̂̃TCYъ튯̃TCY̐SqԂ炩ɂDCXlq̓VEWEoGɂۑĂĈ̃TCY𐧌䂷<a href="#R24"><sup>24)</sup></a>D̂̃TCY튯̃TCYCėގ^pNɂ萧䂳Ă邱Ƃ͋[D
@튯̃TCY̐̔j]ɂ肪𔭏ǂ邱ƂC̂̈ێɂĊ튯̃TCY̐䂪K{̖͂Ƃ炩ɂꂽD튯̃TCY̐S̃^pN񍐂Ă邪CHippo-YAP/TAZVOi`BoH͂̒SIȖSDߔNCHippo-YAP/TAZVOi`BoHWIƂC܂ފe̎̎Ö@̊JڂĂ<a href="#R25"><sup>25)</sup></a>D
@C튯̃TCŶ̃TCYɑ΂܂Ɍ`邢͈ێ@\ɂẮC܂słD̋@\ɂ́CזEÕTCY̏񂪕KvƍlDŋ߁CVEWEoGpCCXlq̃VOiPI3KTOR̊Hippo-YkiVOi`BoHƃNXg[N邱Ƃꂽ<a href="#R26"><sup>26)</sup></a>DCXlq̃VOiYkiCזE̐𑝉C튯̃TCY𑝑傳DCXlqHippo-YAP/TAZVOi`BoHƂ̃NXg[ŃC̋@\𖾂錮ɂȂ\D

<h2> </h2>
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</ol>
<div class="au-profile">
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<span class="author">{ iNorio Miyamuraj</span>
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<strong>m jiHiroshi Nishinaj</strong>
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URLF<a href="http://www.tmd.ac.jp/mri/dbio/index.html" target="_blank">http://www.tmd.ac.jp/mri/dbio/index.html</a>
</div>
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