veA\[̍쓮@\Ɛp̐V

<strong>c Ε</strong>
iww@wn `ӊwj
emailF<a href="mailto:smurata@mol.f.u-tokyo.ac.jp">cΕ</a>
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̈Zr[, <strong>3</strong>, e011 (2014)@<a href="http://dx.doi.org/10.7875/leading.author.3.e011">DOI: 10.7875/leading.author.3.e011</a>
Shigeo Murata: <strong>A new understanding of action mechanism, physiological roles and regulation of the proteasome.</strong>

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<h2>v </h2>
@26SveA\[͖2.5 MDaC66̃Tujbg\C^jɕK{̋ȃ^pN̂łDȂ̂悤ɕGȍ\Ă̂Cǂ̂悤Ƀ^pN̕sĂ̂C܂悭킩ĂȂDߔNCNCIdqp\ł̍\͂傫ȐiW݂ĂD܂CveA\[̗ʂ̑ǂƂC_oϐCVȂǃqg̎Ƃ̂ɂĂ̕񍐂~ςĂDveA\[̔ǂ̂悤ɐ䂳Ă̂ɂĂقƂǖ𖾂łCזE̓Ỏh{XgXɉăveA\[̔䂳C̉CXgXCזE̋@\ێɏdvȖ͂Ă邱Ƃ킩ĂD

<h2>͂߂</h2>
@זE͍P퐫̈ێCXgXC@\ϊȂǂs邽߂̎îЂƂƂāCזE^pN𗘗pĂDזEɂĖiׂj^pNsǂȃ^pN̑唼́C̖ڈƂărL`tꂽ̂CveA\[Ƃ΂鋐ȃ^pN̂ɂZyv`hfЂɂ܂ŏDrL`-veA\[n͐^jɂĕK{̍זE^pNnł邪C̗v_́CWIƂȂ^pN̕LƍI𐫂̗CсCł͂Ȃɐ䂳ꂽɂDM҂w@1990N㔼̓rL`-veA\[n̋̓Iȏdv킩͂߂΂̂łĈ̂̌̐iW͂߂܂CזEC`qCVOi`B͂߂ƂLۂɂĕK{̐@\ƂĂ͂炢Ă邱Ƃ炩ɂȂCߔN̐Ȋw𗝉邤ŕK{̌łD
@rL`-veA\[nɂĂ܂傫ȓɂ܂Ă̂C^pN̕sveA\[łDveA\[͑̃Tujbg\z邫߂ĕGȃ^pN̂ł邪CN̍\͂̐iWɂC̏ڍׂȍ쓮@\킩ĂD܂CveA\[̋@\ƘVƂ̊֘AC̔̐V@\炩ɂȂD̃r[ł́CƂɂNŖ炩ɂȂĂveA\[̍쓮@\Ɛp𒆐SɉD

<h2>1DveA\[̊bm</h2>
@veA\[͍yꂩMނɂ邷ׂĂ̐^jɂčxɕۑꂽ\^pN̂łDrL`ꂽ^pN𕪉̂́CveA[[20SRAqiCPC邢́C20SveA\[Ƃԁj̗[܂͕Б19S䗱qiRPƂԁj26SveA\[łD́C44 nmCő咼a20 nmC2.5 MDaɂyԋȍyfłi<a href="#F1">}1</a>jD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@veA\[̍\ƍ\</strong>
iaj26SveA\[̓dqƂ̃JbgfDhCcMax-PlanckInstitute of BiochemistryWolfgang Baumeisterm苟^D
ibjTujbg̍\D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/10/Murata-3.e011-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2014/10/Murata-3.e011-Fig.1.png&amp;caption=fig1-caption-text]

@20SRAqX\͂ȂĂC\̏ڍׂĂ<a href="#R1"><sup>1)</sup></a>D7ނ̃Tujbg1`7Ȃ郿OƁC7ނ̃Tujbg1`7ȂȌɐςݏdȂ̒M̌`ĂCO̓ǂɃveA[[SIoĂD1C2C5݂̂veA[[DҒœɂẮCyꂩۑĂ\Iɔ^Cv20SRAq̂قCC^[tFɉĔU1iC2iC5iƂveA[[قȂTujbggݍ܂ꂽƉu^20SRAqC̖Ɖu^20SRAq炳Ƀ5iB玿ɓٓIɔTujbg5tƒuB^20SRAq݂CMHCNXIƉuɂĂ߂ďdvȂ͂炫Ă邱ƂmĂ邪CڍׂɂĂ͂قɂ䂸<a href="#R2"><sup>2)</sup></a>D
@20SRAqPƂ̂Ƃɂ͓ƂȂ郿O͕̒ĂCJĂ13̋`lƂȂCقꂽiAtH[fBOꂽj^pN݂̂ʉ߂łDʉ߂^pN̓OƃO`antechamberiT̊ԁjƂ΂ԂɂĉقꂽԂňێCɁC2̃Oɂ܂ꂽcatalytic chamberiG}ԁjɈړĕD
@20SRAqɂ镪̂߂Ɋ^pN̑Oŝ19S䗱qłDATPase6ނ̃TujbgRpt1`Rpt6ȂATPaseOɁC ATPaseȂ13ނ̃TujbgRpn1`Rpn3CRpn5`Rpn13CRpn15^pN̂łCwIȐ₻̌`@\CRpt1`Rpt6CRpn1CRpn2CRpn13ȂꕔibasejƁCRpn3CRpn5`Rpn9CRpn11CRpn12CRpn15ȂWilidj2ɋ敪邱Ƃł<a href="#R3"><sup>3)</sup></a>i<a href="#F1">}1</a>jDꕔƊW͓ƗČ`ꂽ̂ɉ19S䗱qł邪CRpn10͊19S䗱qɉD
@܂ŐwIш`wIȉ͂C̃TujbgɂĂ̓rL`ꂽ^pN̕ɂmĂDATPaseTujbg͊^pN̉قC20SRAq̃O̊JC20SRAqւ̊^pN̑荞݂sDRpn10Rpn13̓rL`𒼐ڂɕߑgrL`éhƂĂ͂炭DRpn11Zn<sup>2+</sup>^veA[[łCrL`̍ؒf邱Ƃɂ^pN烆rL`؂藣𑣐iD
@̑̃Tujbgǂ̂悤ɗL@IɘAgărL`ꂽ^pN̕\ɂĂ̂𗝉邽߁C19S䗱q̍\͂Ȃ炭Җ]ĂC\̕GCsψꂳ獢߂ĂDCÑNCIdqɂPq͋Zp̐iɂC26SveA\[Ŝ̍\7`10̍\Ŗ炩ɂȂCveA\[̍쓮@\̗IɐiW<a href="#R4"><sup>4-11)</sup></a>D

<h2>2DveA\[̍쓮̕q@\</h2>
@NCIdqɂ͂𒆐SɁCʂ̃Tujbgގ^pŇ\͂̏₱܂ł̐wIȉ͂̒~ςQƂ邱ƂɂC19S䗱qɂ邨̂̂̃Tujbg̔zu⊈S̈ʒuCATPɂƂȂ\ῶ߁C19S䗱qɍIȂ݂ŃrL`ꂽ^pNĂ@\킩ĂD
@ATPaseTujbgRpt1-Rpt2-Rpt6-Rpt3-Rpt4-Rpt5̏ɂȂŃO\`C̒ɂ̓`l`DقAAA<sup>+</sup>AtH[_[[ƓlɁCߑAr-[viAr-Faromatic hydrophobicCFёajƂ΂aɕx񂾗̈悪̂̂̃Tujbg`lւނē˂oĂDATP̑݉i^pNƉĂȂԂ͕jł́CAr-[vRpt3𒸓_CRpt2ƂCRpt6̂A点Kiɔz񂵁CɁCATPaseÕ`l̎20SRAq̃`l̎XĂDC𐫂ATPAiOłATPS̑݉i^pNƉԂ͕jł́Ĉ̂Ar-[v͂قړ̕ʂɂ낢CATPaseÕ`l̎20SRAq̃`l̎v<a href="#R5"><sup>5)</sup></a>i<a href="#F2">}2</a>jD̂悤ɁCATP̉TCNɂƂȂ̍\̕ωɂC^pN̍\قȂ20SRAqւƑ荞ł@\킩ĂD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@rL`ꂽ^pN̕ɂveA\[̍쓮@\</strong>
1jveA\[̃rL`eRpn10/邢Rpn13ɂ^pÑrL`ߑD2j^pN̂\̈悪ATPase`lAr-[vɂߑꕪւƉ^ÂD3j^pN̉ق͂܂ƁC19S䗱q͍\ωNCATPase`l20SRAqւ̒ʘHɔz񂷂ƂƂɁCErL`yfRpn11̊SATPase`l̒ɔzuD4j^pN̉قisrL`̍Rpn11S̕t߂܂ňړƁCrL`؂藣D5jɉقisC^pN20SRAqւƑ荞܂ĕD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/10/Murata-3.e011-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2014/10/Murata-3.e011-Fig.2.png&amp;caption=fig2-caption-text]

@ATPaseO20SRAq̃OƒڂɉDRpt2CRpt3CRpt5C[ɑ݂HbYXziaA~m_-`V-Cӂ̃A~m_ȂzjTujbĝɂ|Pbgɓ˂h邱ƂɂCOɍ\ωNJCقꂽ^pN20SRAqւƑ荞܂D
@rL`ꂽ^pN̕ߑRpn10Rpn13ɂsDgrL`éh̓Aeî悤19S䗱q̒̎ӕɌ݂90𗣂ĈʒuĂi<a href="#F3">}3</a>jD܂ł̐wIȉ͂C4ȏ̃rL`AȂegrL`ŏCĂ邱Ƃ^pNveA\[ɂIɕ邽߂ɕKvł邱ƂmĂD2̃rL`ê̋͂傤ǃegrL`̒ɑ邱ƂC̋ɂ荂eaŃrL`ߑĂ\ĂD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@26SveA\[̍𑜓x̓dq</strong>
iajWiFj͊ꕔiFj̑ʂɒCɈꕔ20SRAqiDFjƂiEMDB IDF<a href="http://pdbj.org/emnavi/emnavi_detail.php?id=1992" target="_blank">1992</a>jD
ibj19S䗱qɂATPaseOƃTujbg̔zuiPDB IDF<a href="http://service.pdbj.org/mine/Detail2?PDBID=4cr3&PAGEID=Summary" target="_blank">4CR3</a>jDƂɁC^pNĂƂɂRpn11ATPaseO̒ɈʒuDrL`êłRpn10Rpn1319S䗱q̎ӕɈʒuD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/10/Murata-3.e011-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2014/10/Murata-3.e011-Fig.3.png&amp;caption=fig3-caption-text]

@CrL`݂̂ł̓veA\[ɂ镪ɂ͏\ł͂ȂC^pN30A~m_cȏ̒̔\̈ƂKvłC̗̈悪ATPase`lɓ荞Ar-[vɂߑ邱ƂɂC͂߂ĕւ̉^Â<a href="#R12"><sup>12)</sup></a>D
@ErL`yfRpn11̓rL`̍^pN؂藣D̂͂炫̓rL`ꂽ^pN̕ɕK{̉ߒł邪CATP̉ɈˑIɊ^pN̉قJnĂ͂߂ĎsDȂ킿CATPaseO̗̍\̕ω19S䗱q̑Ŝ̍\ωƂȂC^pN̉ق̂Ƃɂ́Cق|yv`hԋ߂Ō邩̂悤ɁCRpn11̊SATPaseÕ`l̓10𒼏Ɉʒu悤ɂȂ<a href="#R7"><sup>7,9,10)</sup></a>D^pNrL`Ă镔ʂ܂ŉقi݁C`l̓̕t߂ɃrL`ƁC؂藣Ƃɂ胆rL`ATPase`lɋl܂邱Ƃӂłi<a href="#F2">}2</a>jDۂɁCN[݂̂rL`鋅^pNC[ɉق̊Jn𓱂\̈ZC̋^pNRpn11veA\[pƁCC[ق͂܂CЂċ^pN̉ق܂ł͋N邪CN[̃rL`̂Ƃŉق͒~<a href="#R7"><sup>7)</sup></a>D
@ErL`yfRpn11̊SƃrL`eRpn10Rpn13̃rL`̈Ƃ̋͂ꂼ75łCegrL`łRpn10邢Rpn13rL`ߑRpn11ErL`sƂ̂ł鋗łD̂Ƃ́CegrL`IȕVOiƂȂ@\Ɗ֌WĂ邩ȂD
@ꕔRpt1`Rpt6ATPaseORpn1CRpn2CRpn13Č`DRpn1Rpn2̓rL`ꂽ^pN̕𐧌䂷^pN̑ƂĂ͂炭DRpn1̓rL`lhCƂ̌\CrL`ꂽ^pN26SveA\[܂ŃN[ghHR23UbiquilinƂVg^pNCrL`g~OĕxErL`yfUsp14/Ubp6CveA\[ɂărL`̐LsrL`K[[ȂǂN[gDCRpn2̓rL`eRpn13̌TujbgƂĂ͂炢ĂCRpn2Rpn1326SveA\[̒̎ӕɈʒuĂ<a href="#R4"><sup>4,11)</sup></a>i<a href="#F3">}3</a>jDRpn13ɂ͂ɒErL`yfłUCH37D̂悤ɁCꕔɂĂ̓rL`ꂽ^pNN[gC̃rL`̒𐧌䂷^pNC΃^pN̐̏ƂȂĂ\lD
@WƂ̂́CveA\[̒𑜓x̓dqɂāgӂĥ悤ɂ݂镔ɑ邾낤Ƃ̗\z疽ꂽ̂CNCIdqɂ蔻W̍\͈ӊOȂ̂łDRpn9CRpn5CRpn6CRpn7CRpn3CRpn12́C݂C[PCIhCďɒSɉC炨̂̂N[wL悤ɕˏɐL΂Ă<a href="#R6"><sup>6)</sup></a>i<a href="#F3">}3</a>jDMPNhCRpn8Rpn11̓weʑ̂`CW\TujbgC[ɑ݂wbNX𑩂˂悤ɂĉĂDWƊꕔ͂̂̓ƗČ`ꂽ̂ɉ19S䗱qɂȂ邪CW͊ꕔɂӂ̂悤ɂԂ̂ł͂ȂCꕔ̑ʂ悤ɒCRpn11K؂ȏꏊɔzuƂƂɁCRpn5Rpn6N[20SRAq̃1у2ƒڂɑݍp邱ƂɂC20SRAq19S䗱qƂ̌⋭Ă邱Ƃ炩ɂȂ<a href="#R4"><sup>4,11)</sup></a>i<a href="#F3">}3</a>jD
@ȏ̂悤ɁĈ̂̃Tujbĝ͂炫̕q@\炩ɂȂCCveA\[WIƂnC@\m̑̃Tujbg̖ɂāC傫ȃqg邫ɂȂƍlD́Cɏڍׂȍ\𖾂炩ɂƂƂɁCveA\[Ɖ^pN̍p@\𖾂炩ɂ邽߁C26SveA\[Ƃ̂̍̕\̉𖾂҂D

<h2>3DveA\[ƘVю</h2>
@veA\[̍쓮@\͖炩ɂȂ邪CveA\[̗ʂ@\ǂ̂悤ɐ䂳Ă̂ɂĂ͂قƂǉ𖾂ĂȂ̂łDCveA\[̗ʂ⊈̑ƘV邢̓qg̎Ƃ̊֘Am͂߁CveA\[̗ʓIȐƐюƂ̊֘AdvɂȂĂD
@VɂĊώ@錻ۂƂāCQm̕s萫CGsWFleBbNȕωCh{mُ̈C~gRhA̋@\ُCזE̋@\ቺȂǂ邪Cُ^pN̒~ςV̎vȓ̂ЂƂłDۂɁC^pN̋ÏW͐_oϐ͂߂Ƃɐ鑽̎Ɋώ@<a href="#R13"><sup>13)</sup></a>D
@܂łȂCveA\[͍זEɂ^pN̍P퐫̈ێɂĎvȖ͂ĂCVւ̊֗^͏\ɗ\zƂłDۂɁC܂܂ȐɂăveA\[̋@\ƂƂɒቺ邱Ƃώ@ĂCveA\[̋@\lדIɒቺƁCɂƂȂ^pN̋ÏW̏opx㏸C_oϐӈُ𐶂邱Ƃ񍐂Ă<a href="#R14"><sup>14)</sup></a>DCނƂĂ͈ٗɒn_JfolY~͍veA\[ƁCqgɗR錒N̐ۉזEN҂Ȃ݂̃veA\[ێĂ邱ƂȂǂCveA\[̋@\ƘVƂ̊֘A͋<a href="#R15"><sup>15)</sup></a>Dł́ClדIɃveA\[̊㏸Ύ͉т̂낤H@܂ŎۂɁCoyCCVEWEoGCqgזEɂāC̐Ƃx錋ʂĂD
@oył͓]ʈqRpn4iƂƁCveA\[̃TujbgƌFē肳ꂽ̂ŁC̖ĂjveA\[ׂ̂ẴTujbg̈`qĂɓ]ʂ邱ƂmĂ邪CRpn4𑝉oył͕1.5{ȏ<a href="#R16"><sup>16)</sup></a>DRpn4̓veA\[̈`q݂̂Ȃ炸ق̈`q̓]ʂi邪C֊֗^̒mTor邢Sir2RXgX]ʈqłYap1Rpn4̑ɂɂ͊֗^Ă炸CveA\[̗ʂ̑傪Kv\ł邱ƂĂD
@זEɂĂ̓veA\[̑傪邱ƂړIɎĂDVEWEoGłRpn11PƂŉߏɔ邱ƂɂveA\[㏸ČʁCƂƂɉɂƂȂϐ^pN̒~ςɂ_oזE}ꂽ<a href="#R17"><sup>17)</sup></a>DveA\[33ނ̃TujbgWČ`Ă̂ŁCP̃Tujbg̉ߏ蔭ɂveA\[㏸邱Ƃ͕svcł邪CȂƂCRpn11veA\[̊Oł͂炢ĂƂ񍐂͂ȂCveA\[̌`Ȃ炩̋@\ɂ董iĂƐDveA\[̒PTujbg̉ߏ蔭ɂveA\[̑Ǝ́CɂĂώ@ĂDłFOXOt@~[]ʈqłDAF-16ɈˑIRpn6̔㏸ɂ͂炢Ă邱ƂꂽDRpn6PƂ̉ߏ蔭łveA\[㏸Ĉُ^pN̕iC_XgXMXgXȂǃ^pNXgX̂Ƃł̎炷<a href="#R18"><sup>18)</sup></a>D
@VEWEoGɂāCȂP̃Tujbg̉ߏ蔭veA\[̋@\㏸̂C̋@\͕sł邪CP̃TujbgveA\[֘A`q̍ɂveA\[̋@\i͂قɂmĂD}EX̎󐸏ł1זE4זE̊ԂZPACƂveA\[`Vy𔭌ăveA\[𑝎Y邱Ƃɂ^pNxł̕ꐫ-󐫓]ڂ𑣐iĂ邱<a href="#R19"><sup>19)</sup></a>Cqg̍ԎזEł̓5ߏ蔭邱ƂɂveA\[㏸\ێĂ邱<a href="#R20"><sup>20)</sup></a>CESזEiPSזE͑\ێ邽FOXO4Rpn6̔㏸Ă邱<a href="#R21"><sup>21)</sup></a>C񍐂ĂCזEgD̐ɂveA\[̌`ɂ闥iKȂǁCveA\[̑Y̐헪قȂĂ̂ȂD

<h2>4DveA\[̔̐@\</h2>
@veA\[ɑgݗĂċ@\邽߂ɂ́C33ނׂẴTujbgCсC̏WٓIȕqVyĔKvD
@ɏqׂƂCoyłRpn4veA\[̈`q̓]ʂ邱ƂmĂDRpn4̓veA\[̋@\̂Ƃ̓rL`ɈˑIєˑIȌoHɂ肽Ă邪CveA\[̋@\ቺƕ܂ʂCPACEz㗬ɂveA\[֘A`q̓]ʂĂɗUDRpn4oył͖쐶^Ɣ׃veA\[̗ʂ邵ቺ邱ƂCRpn4͗U̔ƂƂɊbʂ䂵Ă邱Ƃ킩D
@ɂĂl̃tB[hobN@\݂̑邱ƂmĂD1zɂRpn4Ƒȃ^pN݂͂ĂȂC_XgXɂ͂炭]ʊ^pNƂĒmNrf1́CveA\[̈`q̗U̔ɂ͂炢Ă邱Ƃ炩ɂȂ<a href="#R22"><sup>22)</sup></a>DNrf1N[ɖђʗ̈E̖^pNłCʏ͏E̊֘AɂPIɃveA\[ɂ蕪]ʊ𔭊Ȃ悤ɂĂDCveA\[̋@\ቺC̃XgXɍזE炳ꂽ肷ƁCNrf1͑̕jQvZVOĊjւƈڍs邱ƂɂveA\[̈`q̔U<a href="#R23"><sup>23)</sup></a>DNrf1̃vZVOyf̓veA\[̂łƂĂ<a href="#R24"><sup>24)</sup></a>DNrf1זEł̓veA\[̊bʂ͂قڐłCNrf1͎ƂăveA\[̗ʂ̃tB[hobNɂ͂炢ĂCbIȔ𐧌䂷ق̕q@\݂̑lDCj[ɓٓINrf1mbNAEg}EX̓veA\[̋@\̒ቺĕϐ^pN̒~ςƐ_oϐЂNƂCNrf1ɂveA\[̈`q̓]ʐ͌̂̍P퐫̈ێɂďdvȂ͂炫Ă邱Ƃ킩<a href="#R25"><sup>25,26)</sup></a>DߔNCR܂ƂăveA\[jQ܂gpĂ邪CᇍזENrf1̊ɂtB[hobN@\ɂveA\[̔𘴐i邱ƂveA\[jQ܂ɑ΂ϐ̌ɂȂĂƍlĂDNrf1̗U̔𓯎ɐ䂷邱Ƃł΁C̑ϐ@\̍\ɂȂƊ҂D
@זECƂɁCh{ԂɉveA\[̔̐@\ɂĂ킩͂߂DmTOR1͕xh{̏Ԃ␬qɉĊC^pN⎉̐͂߂Ƃӂ̓p𑣐iזE̐⑝B𐳂ɐ䂷}X^[^pNƂĒmĂDɁCveA\[𑝉邱Ƃɂ^pN𑣐iCזEɂA~m_v[𑝑傳Ă邱Ƃ킩<a href="#R27"><sup>27)</sup></a>DmTOR1̃}X^[]ʈqłSREBP邱Ƃ͈ȑOmĂCSREBPNrf1̓]ʂ𘴐i邱ƂɂveA\[̈`q̓]ʂ㏸Ăi<a href="#F4">}4</a>jDveA\[ɂ^pNזEɂA~m_v[̈ێɏdvł邱Ƃ͈ȑO玦Ă邪<a href="#R28"><sup>28,29)</sup></a>CQ̍ۂɃA~m_̊mۂs^pNnłI[gt@W[mTOR1ɂ}邱ƂlƁCזEɂ2啪n̎g̑Δ䂪[D

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@veA\[̔Ɖh{уXgX</strong>
veA\[̔́CmTOR1VOi`BoHɂ鑝BVOiƂĂCFOXOVOi`BoHɂXgXϐƂĂCłUD܂CveA\[̋@\ቺۂɂNrf1̒~ςъɂĂUDCveA\[̊bʂ𐧌䂷邵݂͂܂słD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/10/Murata-3.e011-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2014/10/Murata-3.e011-Fig.4.png&amp;caption=fig4-caption-text]

@PI3K-AKTVOi`BoHɂ萳ɐ䂳mTOR1Ƃ͔΂ɁCFOXOPI3K-AKTVOi`BoHɂ蕉ɐ䂳]ʈqłCh{Q₳܂܂ȃXgXɑΉčP퐫̈ێɂ͂炫CI[gt@W[͂߂Ƃىp^pNP퐫̈ێ@\𔭓Dɏqׂ悤ɁCESזEłDAF16邢FOXO4Rpn6̓]ʂ㏸邱ƂɂveA\[̋@\𘴐iCُ^pN̏oɂŐyĂ<a href="#R18"><sup>18,21)</sup></a>i<a href="#F4">}4</a>jD
@mTOR1͘V̑iэזEB̑iɍpCFOXO͂̋tɍpɂ炸CǂveA\[̔U邱Ƃ͂قɂDCveA\[rL`̖ڈɂĂǂ̃^pN𕪉邩זE@\𐧌䂷v_łƍlƁC̏ꍇCveA\[ƂƂɗUĂ郆rL`K[[Ƃ̓ٓIȊ^pNp̗̌ɂȂł낤D؈ޏk̍ۂFOXO3ɂU郆rL`K[[MuRF1MAFbx/atrogin-1ȂǂDłDxh{̂ƂэזEB̂ƂɊɕăA~m_̋ƂȂ^pNƂ͂ł̂C[łD

<h2></h2>
@veA\[ɂāCNő傫ȐiẄ݂ɂڂD̂ق̏dvȃgsbNXłveA\[̑lCveA\[ƉăveA\[̋@\𐧌䂷^pNCveA\[̕qWɂẮCقQƂꂽ<a href="#R30"><sup>30)</sup></a>D
@20SRAq̊ʂjQveA\[jQ܂ɑ΂ʓIȍR܂Ƃėp悤ɂȂĈȗCveA\[͗L]ȑnWIƍl悤ɂȂĂDveA\[̓@\炩ɂȂɂāCVp_jQ܂JDƂ΁CRpn13ɂ郆rL`̔Fɑ΂jQ܂R܂ƂėL]ł邱Ƃ񍐂Ă<a href="#R31"><sup>31)</sup></a>D̔΂ɁCveA\[^̒ErL`yfUsp14jQăveA\[ɂ镪𘴐i邱ƂɂC_oϐ̎ÂƂčזEɂُ^pN𕪉悤Ƃ鎎݂ȂĂ<a href="#R32"><sup>32)</sup></a>D
@25No߂邢܂ȂCveA\[̐VpÂĂC̊֗^̈͊gÂĂDCVCCƉuL[[hɁCveA\[̏dv͂ĂƍlD

<h2> </h2>
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</ol>
<div class="au-profile">
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<span class="author">c ΕiShigeo Murataj</span>
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URLF<a href="http://www.f.u-tokyo.ac.jp/~tanpaku/" target="_blank">http://www.f.u-tokyo.ac.jp/~tanpaku/</a>
</div>
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