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emailF<a href="mailto:itohru@iam.u-tokyo.ac.jp">ɓ </a>
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̈Zr[, <strong>2</strong>, e007 (2013)@<a href="http://dx.doi.org/10.7875/leading.author.2.e007">DOI: 10.7875/leading.author.2.e007</a>
Tohru Itoh & Atsushi Miyajima: <strong>Regulatory mechanisms for adult liver progenitor cells that support liver regeneration.</strong>

<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/06/Miyajima-2.e007-PDF.pdf" target="_blank"><img class="size-full wp-image-112 alignright" title="Download PDF" src="/images/downloadPDF.png" alt="Download PDF" width="100" height="20" /></a>
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<h2>v </h2>
@̑͂߂čĐ\͂CĐ̃fƂđ̌sĂDɂ킽C̉͂̒Sɂ͕̂̐؏̂̂̍Đ̉ߒłC͐n̍זE̔⑝BɂS㏞̍ĐłDŁC򕨂ŕȂǂɂdĂ邢͖IȏQ̍זÊ̑BjQꂽꍇɂ́CȊ̑ł݂͑̔F߂ȂȊ̑OזEđCꂪ̍זE_ǏזEւƕ邱Ƃɂ̑̋@\񕜂̂ƍlĂDߔNĈ悤Ȋ̑OזEɈˑ̍Đqg̕aԂ蔽f̂ƂĒڂ߂悤ɂȂD̑OזE̎́CƂ킯C̗RɂĂ͂܂c_ÂŁC̐@\ɂĂ̗͋}ɐi݂Dł́Čƍ̉ۑɂāC̑OזE̊ɏdvȃjb`VOiɊւM҂̍ŋ߂̌ʂ܂D

<h2>͂߂</h2>
@ĐÂ傫Ȓڂ߂ĂDiPSזE𒆐SƂ̃u[̂ȂɂāCςlX̎vׂgĐh̃C[WƂ́C@\sSɂÂȂ肵ǓŐlדIɂ肾ƒuƂ悤ȗނ̂̂ȂDŁĈɂ͂ƂƁCQ⑹ɂ莸ꂽgD튯@\IɏC鎩IȍĐ\͂x܂ŔĂDCviÂ悤ȔrIȐ͂߂čĐ\͂̂ɑ΂CcOȂCqg܂ޚMɂĐ\͂͌IłD
@M̑̂ȂŗOIɍĐ\͂Ƃ̒m̂͊̑łDƂ΁C2/3OȓIɐ؏ig̐؏hƂ΂jꍇłCc̕Zԁi}EX̏ꍇC1TԒxĵɂƂ̑傫ւƍĐ@\񕜂邱Ƃ\łi<a href="#F1">}1a</a>jD̂悤Ȋ̑̍Đ\͂͂͂邩̂mĂ悤ŁCMV_b̂ȂɂveEẌbƂēoꂷDȂ킿CVォ΂𓐂ŐlԂɗ^veEX̓[EX̓{𔃂CR[JTXRɂđhɊ̑܂̂Cނ͖̊̑ӍĐ邽ߗꂵ݂𖡂킢Â邱ƂɂȂCƂ̂łDȊw̌ɂẮC̐؏ɂƂȂ̑̍Đ̎f1930NɊmĆCς烉bgΏۂƂĂCł́CgXWFjbNmbNAEgȂǈ`qς̉\ȃ}EX̌np悤ɂȂĂDĐ̕ɂЂƂ̃p_CƂĒNɂ킽͂C܂łɑ̒mWςĂD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@̑̍Đɂ2̗l</strong>
iaj㏞i㏞ĐjDfɂ镔̐؏ł́C̗tOȓIɐ؏DcgD͏QĂ炸Ĉ܂ܔ傷邱ƂɂCƂ̑̑傫񕜂i㏞jD̉ߒ́CcgDɂāCn̍זEъ̑\ق̍זE傠邢͑B邱ƂɂsD
ibjOזEɈˑ̍ĐD򕨂ŕȂǂɂdĂ邢͖IȏQ̑ł́Cn̍זÊ̑BjQD̂悤ȏ󋵂ɂẮCȊ̑OזE̊UCꂪBѕ邱ƂɂVɍזEĐsƍlD
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<h2>1D̑̍\Ƌ@\ёgD̈ێ</h2>
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<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@̑̍\</strong>
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ibjt͗ޓƂ΂э׌ǖԂʂȂ̍זEƂ̂ŕŝCSÖɗꍞ݊̐ÖɏWĊ̑痬oDC̍זEɂĎYꂽ_`́C̍זÊɌ`эג_ǂւƔroC_ǂoRĊ̑̊OւƔroD_ǂC̓喬ƓlɁC̑ɂĕ}\ƂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/06/Miyajima-2.e007-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2013/06/Miyajima-2.e007-Fig.2.png&amp;caption=fig2-caption-text]

@ӂł̒S튯ł̑́Ĉقɂ߂đ̏dvȐ@\D@\̑啔͎זEł̍זEɂSĂD̍זE͋@\IȒSłƓɁC̑Ŝ8قǂ߂Ă邱ƂC\Ȃɂ͂Ȃ邪C̑̍ĐƂ͑`Iɂ͊̍זE̍Đ̂ƂƂD̑̑gDɂāC̍זE͖喬ƒSÖƂ2ނ̌ǂ𗼒[Ƃ鎲ɂĔz񂵁Ĉ悤Ȋ̍זÊޓƂ΂э׌ǂsi<a href="#F2">}2b</a>jD̑\̍זEi̎זEjȊO̍זE͂ЂƂɊ̔זEƏ̂C_ǏזECזECۉזECޓזECNbp[זÊقCe̖Ɖun̍זEȂǂɊ܂܂D
@̑̍Đ𗝉邤ł́CƂ͕ʂɁCnזEƂȊOƂʂ̂̂LłD̑ɂĂ͊̍זEђ_ǏזEn̍זEł邪C͑gD̍\ɂĘAđ݂ĂD̍זEƒ_ǏזEƂ̐ڑ͉UwIɁgwOǁhicanal of HeringjƂ΂\ƂD̍זÊdvȋ@\̂ЂƂ_`̎YłC̍זEɂĎYꂽ_`́Cאڂ̍זÊɌ`Ԍiэג_ǁjւƕ傳Dэג_ǂɗo_`́CwOǂʂĒ_ǏזEɂ\Ǎo\ł_ǂւƒŏWC̑̊O֏ôŏIIɏ\wւƔroD
@̍זEђ_ǏזẺ͔ߒɂāCَ̊̑ɑ݂鋤ʂ̑OזEłg̉זEhihepatoblastjɗRD̑w̕ł́C̍זEђ_ǏזEւ̓̕\זEg̊זEhƒ`C̉זEَ͑ɂ̊זEƈʒuÂĂ<a href="#R1"><sup>1)</sup></a>DȂC̉זEƓ邢͗ގזȆ݂́Ĉ̊̑ɂĂ͖mɂ͔F߂ȂD̂̊̑oĔ|{nɋꍇɍB\Rj[`\C̕\זȆ݂͕񍐂Ă̂<a href="#R2"><sup>2-4)</sup></a>C̍זEƂƂ̐̂̊̑ɂĂǂɑ݂Cǂ̂悤ȋ@\ŜC̑̑gD̃eiXiȏ󋵂̂Ƃł̑gD̃^[I[o[j̑̍ĐɊ^Ă̂ǂ́C܂ĕsłDtn⒰ǁC畆Ȃǂ̑gDł́CnזE͔̎rIZ߁CgDזÊ΂₢זE̋̍sĂ邱Ƃ͖młDɑ΂C̑̑gDi̍זEj̃^[I[o[͐JƂ^CXpōsĂƂCזE̋̊ώ@ѕ]͗eՂł͂ȂDʂɂ́C̍זẼeiX͐n̍זE̕ɂSĂƂlxzIłDŁCȊ̑̑gDɂĂ喬i_ǑjVȊ̍זEݏoCSÖɂނXɑoĂƂ񏥂Ă<a href="#R5"><sup>5)</sup></a>DۂɁC_ǏזẼ}[J[łSox9̈`qɃ^LVtFɂ芈U邱Ƃ̂ł悤ɂCreRri[[iCreERT2j̈`qmbNC}EXpCre/<em>loxP</em>nɂ`IȍזEn̉͂ɂC^LVtF̓^ɂWꂽזE_ǂ̕t߂璆SÖɂނĂɍLĂC1NxŊ̑̂قƂǑŜ߂ƂʂC傫ȏՌ<a href="#R6"><sup>6)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/1981" target="_blank">V_r[</a> łfځjDȂCق̃O[vɂCCreRri[[𔭌ʂ̃}EXnpC̍זEWƂזEn̉͂̌ʂ͂ނ˂ɔےIŁCԂł̊̍זẼeiXɂāC̊̍זEȊOɂ֗^͂قƂǖłƂĂ<a href="#R7"><sup>7,8)</sup></a>D̂񖵏悤ȕ񍐂͓Iɉ߂邱Ƃ\ɂȂ̂CX̎nŗpꂽW̎@iזE̎ށCW̌Ȃǁj̍ĕ]܂߂āČ҂ƂłD

<h2>2D̑̍ĐF2̗l</h2>
@͈̑ꕔ؂ĂĐĂƂǂɂȂƂ̂́C͐mȂł͂ȂDɏqׂƂC͕̑t\ƂĂC̐؏f͒ʏ͗tPʂƂčsD̂ƂCct͂ȂQĂ炸Cɑ݂gDړIȑ͂ĂȂD̐؏̂̂ɂ́Cct傷邱Ƃɂ̑͂Ƃ̑傫Ƌ@\񕜂D؂ꂽtĂѐĂ킯ł͂ȂCāC̑Ŝ̂͂Ƃɂ͂ǂȂD̂悤ȍĐ́g㏞h邢́g㏞ĐhƂ΂i<a href="#F1">}1a</a>jD̉ߒł́Cc̍זEnԂ̂܂܁C債蕪􂵂肷邱ƂɂCgDŜƂĂ̑傫񕜂Đ<a href="#R9"><sup>9)</sup></a>DȂ킿CȑgDזE邢͑OזE̐VȍזE̋͂ȂƂĂD̐؏̂̂̑Đ邳܂͂߂ČI[ۂł邽߁CNɂ킽C̃f̑̍Đ̌ɂS[fX^_[hƂĂD̂ƂC̑̍Đɂ͖ȊזE邢͑OזE͊֗^ȂƂlʂɍL܂D
@ȂC̑̂QƂɑ΂Đ̉lꍇC̐؏f́CӖC߂ĐlדIœꂾƂD̐؏p␶̊̈ڐAsqg͕ʂɂāCbg}EX̂悤ȓ̊̑̈ꕔꂢɐ؂Ƃ󋵂͂قƂǂ肦ȂDނC̑{Q̑́Ci喬j炳X̖򕨂ŕ邢̓ECX̊ȂǂɋNƍlD̂悤ȏꍇɂ͊̍זẺ󎀂A|g[VXUCǔƉuNꂤƂ_ŁC̐؏̂ƂɎc邫ꂢȊ̑̑gDƂ͗l͂ԈقȂDQ̒xy邢͌Ił΁Cאڂ邠邢͎c̍זE􂷂邱ƂōĐ͉\ł낤DȂCQ̒xdĂł蒷邢͖肵ꍇC򕨂Ȃǂ̍pɂ̍זÊ̑BjQꂽ悤ȏꍇɂ́C͂␬n̍זEɈˑĐVXe͏\ɋ@\ȂȂD̂悤ȏ󋵂ł́CȊ̑ɂ݂͑ȂCȍזEođɕ邱ƂɂC̑̍ĐsƍlĂi<a href="#F1">}1b</a>jD
@̂悤ȓȍזẼvg^CvCI[oזEioval celljƂ΂̂łDƂƂ́Cbgɂ2-AZ`A~mtI̓^ɂ̍זȆB}ԂɂāC̐؏邢͎lYf̓^ɂ̑ɏQꍇɁC喬̎ӂɏoזEƂċLqC̗~`̌`Ԃ疼Âꂽ<a href="#R10"><sup>10)</sup></a>D̍זEƒ_ǏזEƂ̋EɈʒuwOǂ̋ߖToC̗҂̐킹ƁCɁCgDwIȊώ@̍זEђ_ǏזEւ̓̕\ƍlꂽƂĈ̊̑iQ̑jɂ̊זȆ㖼ƂȂĂD̂̂Cގ̍זȄQf}EXɂĂU邱Ƃ炩ɂȂC}EXɂĂQƂɏoȍזEɑ΂CI[oזÊ̖LKpX݂D݁C}EXɂăI[oזEȔQfƂĂƂėpĂ̂́C3,5-WGgLVJ{j-1,4-WqhRWiDDCjܗLHa̓^CсCG`IjYRRH̓^2łD́CI[oזEUfƂĈĂ̂́CقȂawiƂĂCUזE̐lԂɂ͈ႢF߂DɁCbgƂ͈قȂQfłāC}[J[̔ɂĂvȂ_DԂ̈Ⴂ܂߁C܂܂ȏQɂUI[oזEɂ͕sώ݂̑邱Ƃ炩ɂȂĈ̖͂č܂˂ĂD܂C̍זE^ɓ̕\Ƃ͌ɂ͎ĂȂƂCQ̂Ƃ݈̂ߐɏo邱ƂC\Ǝȕ\Ē`銲זEƂ́CނCߐɑOזEWcƈʒuÂقmƂlĂDł́CȉCg̑OזEhƂď̂pCꂪĐ̉ߒgOזEɈˑ̍ĐhƂԂƂɂD
@̑OזEɗގזÉCECX̉CAR[̎CAR[b̎CǊ̉ȂǁCqg̊̑ɂX̎ɂĂ΂Ώȏώ@DɁC̓xƎ̒xɂ͑ւF߂CaԐwIɏdvȈӖ̂ƍlĂD̑ɂQɂЂÂۉ̔ǂisCւ̊֗^CƂ킯Ĉ񊲍זEƂ̊֘AȂǂĂ̂́C̎Ԃ͖炩ł͂ȂD̑OזE̗UƂɈˑ̑̍Đ̉ߒ́CߔNCqg̕aԂ蔽f̂ƂĒڂ߁C}ɌiWD

<h2>3D̑OזE̐ƋN</h2>
@I[oזEƂāCƂƁC̑OזE͌`ԊwIȓɂ`ѓ肳ĂC݂ł́C}[J[̔ɂƂÂċc_̂ʓIłD̑OזẼ}[J[ƂāCÓTIɂ̓TCgP`19Cŋ߂ł́CEpCAMCCD133iProminin 1jCSox9CIXeI|`ȂǂpĂ邪Cׂ͂ĐȊ̑̒_ǂɂĂ<a href="#R2"><sup>2,4,6,8,11,12)</sup></a>D̂ƂC_ǏזEƊ̑OזEƂ}[J[̔ɂʂ邱Ƃ͂قƂǕs\ƂĂ悢DɁC̑OזE͖喬ɏoC_ǂɗގNX^[̍\ƂȂ̈ւƍLĂDQ̎ނxɂقȂ邪C̏ꍇɂ͖ĂȊǍo\͌`Ă炸Cג_ǔ邢͋U_ǑȂǂƂ΂D̑OזE̗Uioёjƍג_ǔƂ́CO҂@\IȑʁC҂`ԓIȑʂɒڂĂƂႢłāC{Iɂ͓̌ۂƂ炦ĂƁCM҂͍lĂiłC`̂̂ƂĈjD̑OזE͌ǗȍזEWcƂđ݂Ă̂C̒_ǌnƂ͂ǂ̂悤Ȋ֌Wɂ̂́ĈƂłD
@M҂̌ł́ĈƂ_ǏזEɂ͔CQƂ̑OזEɓٓIɔ^pNƂāCEpCAM̃pOłTrop2𓯒肵Ă<a href="#R4"><sup>4)</sup></a>DȂCTrop2̗̔L╪\ƂȂ炩̋@\IȍقƑւĂ邩͕słDʂ̃O[v́CFoxL1-Cre BACgXWFjbN}EXp邱ƂŏQƂ̊̑OזEW邱Ƃ\łƂ̕񍐂ȂĂ<a href="#R13"><sup>13)</sup></a>DȂ킿CCreRri[[𔭌nKȃ|[^[}EXƊ|킹ƁĈƂ_ǂ͕WꂸCQƂ̑OזEٓIɕW邱Ƃ\łDɁCזEn̉͂ɂC̕Wꂽ̑OזE͊̍זEђ_ǏזEւƕ邱ƂĂD_́CݐFoxL1͊̑OזẼ}[J[ƂȂ邩ǂ͕słC_ł́C̓ȃ}EXnpĂ̂݁Cg̑OזEh𓯒肷邱Ƃ\ȂƂłDCȂ`q̉͂邢̓}[J[̒TȂǂC_ǏזEƊ̑OזEƂ̋ʓ_ё_薾mƂȂ邱Ƃ߂D
@܂C̑OזE}[J[ɗz̍זEׂ͂ĈlɁgOזEhƂĂ̊iѕ\j̂CƂ_̏dvȉۑłD炭C_Ŋ̑OזEƂĂƂ炦Ă͕̂sψȏWcłCɂ͕̒iKɉKw݂ƍlD̓_ŒڂׂȂ̂́Cŋ߂Lgr5Ɋւ񍐂ł<a href="#R14"><sup>14)</sup></a>DLgr5́C̉A|iNvgjɑ݂銲זE͂߁C܂܂ȑgD̊זEɂēٓIɔ}[J[ƂĂ悭mĂD̕񍐂ł́CLgr5-LacZmbNC}EXLgr5-CreERT2mbNC}EXp͂CWɗz̍זȆX̏QƂɓٓIɏoiȂ킿CȊ̑ɂ݂͑ȂjƁC̍זE<em>in vitro</em>IKmCh|{nɂ葝̍זEւƕU邱Ƃ\łCɁC̏Qf}EXֈڐAƐ\ł邱ƂĂCLgr5Q̑ɓٓIȊ̊זE}[J[Ǝ咣ĂDɂCQ̑̐F͖Ăł͂ȂCLgr5ɂWĂ̂́C_ǌnזEъ̑OזËꕔ݂̂ł悤ɂ݂DW̌iCreERT2̔ʂg̕pxjeĂ\邪C̑OזȄWĉȂLgr5̔̈قȂ鈟Wc݂COזEi邢́CזEjƂĈقȂ鐫󂨂ы̂ł΁Cւɋ[D
@bg̃I[oזE̓wOǂɗRƂgDwIȊώ@ɂƂÂC}EX邢̓qgɂĂC̑OזE̗R̓wOǂłƂl炭ʓIłi<a href="#F3">}3</a>jD̍זEƒ_ǏזEƂ̋EɈʒu镔ɁC҂ɓɕ邱Ƃ̉\ȍזEi̋Nj݂Ƃ̂͑ÓȃfɎv邪Cۂɂ́C܂ȏؖ͂ȂĂȂDwOǂ͉UwIȊώ@ɂƂÂċK肳\łCٓIɓ肵W邱Ƃ̉\ȃ}[J[ƁCpčזEn͂邱Ƃ̉\ȌńC_ł݂͑ȂD̑OזE̋NɂẮCɗRƂ咣ꂽC݂͌ł͂قڊSɔے肳ĂDŋ߂ł́CCre/<em>loxP</em>npĊ̍זEђ_ǏזEꂼٓIɕWčזEnǐՂ邱ƂɂC̑OזEɗR邩c__݂悤ɂȂĂ<a href="#R6"><sup>6-8)</sup></a>Dɏqׂ̍זẼeiX̏ꍇƓlɁCpꂽniW̎@jKpꂽ̏Qf}EXɂقȂ錋ʂĂCIȌ͓ĂȂ̂łDςƁC}[J[̔ɂĂ͓̑OזEƂĈĂזEłC̗ǓƂȂ̑ւ̏Q̎ނɂCقȂNɗR\D̉͂̐iWɂCIɂ̓}[J[݂̔̂Ȃ炸CނC̗R╪\ɂƂÂĊ̑OזEƂ΂WcVɒ`ȂCוĂ̂ł͂ȂƊ҂D

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@̑OזĚɂۑ</strong>
̑OזE͏QƂ喬ɂďo邪C̐mȗR͂킩ĂȂDȊ̑ɁCQƂ̑OזÊƂƂȂCȁg̊זEh݂ƂlDꂽ̑OזE͑BȂgDւƐZC̍זEђ_ǏזEւƓɕ邱ƂɂĐɊ^ƍlĂDCP̊̑OזȆgDɂĎۂɓ̕\Ƃȏؖ͂ȂĂȂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/06/Miyajima-2.e007-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2013/06/Miyajima-2.e007-Fig.3.png&amp;caption=fig3-caption-text]


<h2>4D̑OזE̐@\</h2>
@̑OזE̗ŰN悤ȏQ̂Ƃɂ͉ǔ̂ƂȂƂCTNFC^[CL6CC^[tFȂǂ܂܂ȉǐTCgJC̊֗^ĂDȂłC̑OזE̐ɂdvƂmɎĂ̂̂ЂƂCTNFt@~[^pN̂ЂƂTWEAKłD̑ɓٓIȃgXWFjbN}EXAfmECXɂ`qnpāC}EX̊̑ɂTWEAK邱Ƃɂ̑OזEU<a href="#R15"><sup>15)</sup></a>DtɁCTWEAK̎êłFn14̃mbNAEg}EXł́CI[oזEȔQf}EXɂĊ̑OזE̗U}Ă<a href="#R15"><sup>15,16)</sup></a>DC̗}͕I͈ߐ̂̂łC̑OזE̗Uɂ鐧^pN͂قɂ݂ƍlD܂CTWEAK邢Fn14𔭌זE͕Kmɓ肳Ă͂炸C̃VOȋOזEɒڂɍp̂C̍p@ɂ͕sȓ_cĂD
@̑OזE̐ɂ^pNƂāCقɂWntt@~[mĂDbgC}EXCqgɂāC̑X̏QƂWnt̔㏸邱ƁC̑OזEł̓JejoH̊U邱ƂC̃O[vɂ肠ŕ񍐂ꂽ<a href="#R17"><sup>17-20)</sup></a>DC19ނWntt@~[̂CꂪĂ͕̂񍐂ɂقȂĂCdvmɂ͎ĂȂD܂CWntYזEp@C̑OזEɂ@\ɂĂ炩ł͂ȂCŋ߂ɂȂCVɋ[񍐂ȂꂽiɂẮĈɏqׂjD̂قɂCHGF̑OזE̗Uɏdvł邱ƂC̎êłc-Met̃mbNAEg}EXp͂玦Ă<a href="#R21"><sup>21)</sup></a>D̏ꍇ́CTWEAKCɏqׂFGF7Ƃ͈قȂCHGFPƂŊ̑OזE\ɗU邱Ƃ\ł邩ǂɂĂ͎ĂȂD

<h2>5D̑OזExzjb`ƃVOi</h2>
@ʂɁCgDזE邢͑OזÉC̎͂Ƃ܂זEזEOɂ薢̈ێ⑝Bѕ̐邱ƂmĂD̂悤ȓȔ̂Ƃgjb`hinichejƂԁDM҂́C̑OזEɑ΂Ă̊𐧌䂷Ȃ炩̃jb`݂Ɖ肵C𓯒肷邱Ƃ݂<a href="#R22"><sup>22)</sup></a>D̑Ɋ̑OזȄoF߂悤ȏQꂽƂɂ͐ۉ≊ǔ̗UƂȂƂC̑OזEiI[oזEjۉזE␯זEȂǂ̊ԗtnזE⌌tnזEƑݍp邱Ƃ񍐂ȂĂDŁCDDCܗLHa̓^ɂ̏Qf}EX̊̑̑gDؕЂpāCX̊ԗtnזE}[J[ьtזE}[J[ƁC̑OזE}[J[Ƃ̋ƉuFsD̂ƂC}[J[̔wWƂčזEZ\[^[ɂP邱ƂɂāCƂɍזE\ʃ}[J[ɒڂĎʁCThy1i= CD90jz̍זȆOזEɗאڂđ݂邱ƂoD
@Thy1zזE͂܂܊̑OזÊ΂ɑ݂邾Ȃ̂낤H@ɁC̍זȆOזEɑ΂jb`ƂĐ^ɋ@\̂łȂCȂ炩̃VOiĒړIɍp̊𐧌䂵Ă͂łDŁĈ悤ȃVOȋ݂Ǝ̂𖾂炩ɂ悤ƍlDThy1zזE͊ԗtnזE̐CŁC̍זEƒ_ǏזEɕiƑz肳j̑OזE͏nזEƍlDŁCԗtƏƂ̑ݍpɂ邱Ƃ̒mĂX̍זEԃVOi`B^pNɂāC̑ɏQ̂Ƃ̔p^[ĎʁCL͂ȌƂFGFt@~[̂ЂƂłFGF7iʖKGFjoDFGF7̔͐Ȋ̑ɂĂ͂قƂǔF߂Ȃ̂ɑ΂CDDCܗLHa^ɂ̏Qf}EX͂߁C_`T̐̊̏Qf}EX▝̉f}EXȂǁC̑OזE̗UƂȂX̊̏Qf}EXɂČɗUꂽD̔͊̑OזE̎͂ɂĊώ@CɁCZ\[^[pĒPזE敪ɂ`q͂CThy1zCD45ÅԗtnזEFGF7̂ȎYזEł邱Ƃ炩ɂȂDŁCFGF7̓ٓIȎêłFGFe2b͊̑OזEɂċĂD̂ƂCFGF7͊̑OזE̊ƂȂ܂܂ȏQ̂ƂɋʂāCThy1z̊ԗtnזEɂYѕ傳C̑OזEɒڂɍp邱ƂꂽD܂Cqg̋}̉⌀Ǌ̉̊҂̌ɂāCFGF7̔Zx傷邱ƂmFꂽD
@ŁCFGF7mbNAEg}EXpĉ͂ƂCDDCܗLHa^ɂ̏Qf}EX_`T̐̊̏Qf}EXɂāC̑OזE̗UقڊSɗ}Ă邱Ƃ炩ɂȂDDDCܗLHa^ɂ̏Qf}EXpĂɏڍׂɌƂCFGF7mbNAEg}EXł͊̑̏QɑvLӂɏ㏸ĂDŁChLVTCN̓^ɂ̑ɂēٓIFGF7邱Ƃ̉\ȃgXWFjbN}EX쐻͂ƂC̑ɏQ̂ȂԂłFGF7̉ߏ蔭ɂlדIɊ̑OזE̊ЂNƂ\łDɁCDDCܗLHa^ɂ̏Qf}EXɂFGF7ߏɔƁCĐUёiQ̒x͌y邱ƂꂽDȏ̌ʂC̑ɏQꂽƂCFGF7jb`זEƂ̑ݍp̑OזE̊ɏdvł邱Ƃ͂߂Ė炩ɂȂi<a href="#F4">}4</a>jDɁCFGF7̋@\imbNAEg}EXj邢͉ߏ蔭igXWFjbN}EXjɂ̑OזE̗Ũxꂼ}邢͑ꍇɁC̑̏Q̒xƑւđ邢͉PƂ́C̑OזEۂɊ̑̍ĐɐϋɓIɊ^Ă\DIɂ́CFGF7邢͊֘A^pNp邱ƂɂCqg̎X̊̎ɑ΂VK̎Ö@̊Jւ̉p҂D

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@FGF7VOiɂ̑OזE̗̊U</strong>
̑ɂQɉāC喬ɂThy1z̊ԗtnזED̍זEFGF7Yѕ傷邱ƂɂC̑OזE̊ёUgjb`hƂċ@\D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/06/Miyajima-2.e007-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2013/06/Miyajima-2.e007-Fig.4.png&amp;caption=fig4-caption-text]

@ōŋ߁Cjb`VOiɂ̑OזE̐̕ɊւĂ[񍐂ȂĂ<a href="#R23"><sup>23)</sup></a>Dł́C̑OזE̗Uэג_ǔ̊ώ@QC̎vȕaԂɂƂÂg_ǏQhсg̍זEQh2ɑʂC҂ɂ̑OזEjb`̈ႢɒڂĂDqgɂẮC_`̍dς⌴d_ǉOҁCC^̉ECXɂ閝̉҂ɂD}EXɂẮCDDCܗLHa^ɂ̏Qf_ǏQ̍ĐfCG`IjYRRH^ɂ̏Qf̍זEQ̍ĐfƈʒuÂČD_ǏQ̍ĐfɂẮC̑OזE̎͂ɂ̓؃AN`z̐ۉזEił́CؐۉזEƂłjWςCꂪNotch̃KhłJagged1𔭌邱Ƃɂ̑OזEɂNotchVOi`BoHĂDNotchVOi`BoH͔̉ߒɂĊ̉זE_ǏזEւ̗̕Uɏdvł邱ƂmĂC̍Đ̉ߒɂĂ̑OזE_ǏזE̕ւ̕UĂ邱ƂCNotchVOi`BoH̑jQ܂pȂǂ玦ꂽDŁC̍זEQ̍ĐfɂẮC̑OזE̎͂ɂ̓}Nt@[W̏WςF߂ꂽD}Nt@[W͏Qɂ莀ł̍זE̎c[ÐHWnt3a𔭌Dꂪ̑OזEɍpƁCJejoHɂNotch̕ɂNumb̔UCNotchVOi`BoH̊}邱ƂɂCʓIɊ̍זE̕ւ̕iꂽDȂ킿CNotchVOi`BoHWntVOi`BoHƂ2̃VOi`BoH̊̃oXɂC̑OזE̕̕䂳Ƃf񏥂Ăi<a href="#F5">}5</a>jDȂCɏqׂƂC_ǏQƂDDCܗLHa^ɂ̏Qf}EXɂĂ̑OזEɂWntVOi`BoH̊͗UĂCPɗʓIȈႢɂ̂C邢́Cɕʂ̃VOi`BoH̊֗^ɂ鎿IȈႢ̂ȂǁČ̐iW]܂D܂Cł؃AN`z̐ۉזÉCM҂̌oThy1zזEƓ邢͗ގ̂ƍlDThy1zזEɂFGF7VOiɂ̑OזEjb`CG`IjYRRH^ɂ̏Qf}EXɂĂ@\Ă̂ǂ͏dvȌۑłD

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@WntVOi`BoHNotchVOi`BoHƂ̃oXɂ̑OזE̕ɂ^</strong>
̑OזEɂNotchĂD_ǂɏQNꍇɂ͖喬ɂă؃AN`z̐ۉזEjb`\CNotch̃KhłJagged1𔭌邱Ƃɂ̑OזEɂNotchVOi`BoHDɂC̑OזE͒_ǂւƕUDŁC̍זEɏQNꍇɂ́C}Nt@[Wjb``D񂾊̍זE̎c[ÐH}Nt@[WWnt3a𕪔債C̑OזEɂăJejoHNumb̔UDNumbNotchVOi`BoHjQ邽߁Ĉ͂炫ɂC̑OזE͊̍זEւƕUD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/06/Miyajima-2.e007-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2013/06/Miyajima-2.e007-Fig.5.png&amp;caption=fig5-caption-text]

@܂łɏЉTWEAKCWntCHGFCFGF7CNotch𒆐SƂāC܂܂ȃVOi`BoHǂ̂悤Ɋ֘AݍpĂ̂C̉͂ɂC̑OזȄoCC@\𐧌䂷זEԃlbg[N̑Se炩ɂ邱Ƃ҂D

<h2></h2>
@fɂĂ͑㏞ĐC邢́COזEɈˑ̍Đ̂ꂼʂ͂sĂ邪Cۂ̃qg̊̎̕aԂɂė҂͋݂CQ̕ʂxȂǂɉēK؂ȔU邱ƂɂC̑͂̊拭ȍĐ\͂ĂƍlD́C2̍Đ̗lǂ̂悤Ɋ֘A܂AgC̃oX䂳Ă̂ɂœ_ĂKv邾낤D̑̍Đ̕q@\𕪎qэזẼxɂĖ炩ɂ邱Ƃ́C̑̂Đ\͂̔閧ƂƂɁC킠邢͑gD̍Đǂ{̗ɂȂ邾낤DɁC̊OɂiPSזEȂǂlHIɂ肾זECgDCڐAƂÖ@ɂ킦āCɂƂƔĂĐ\͂ЂđƂCʂ̎_ɂ鎡Ð헪̑noɂȂ̂Ɗ҂D

<h2> </h2>
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</ol>

<h2>Ql}</h2>
<ol>
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</ol>
<div class="au-profile">
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<span class="author">ɓ  iTohru Itohj</span>
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<strong>{  āiAtsushi Miyajimaj</strong>
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URLF<a href="http://www.iam.u-tokyo.ac.jp/cytokine/index.html" target="_blank">http://www.iam.u-tokyo.ac.jp/cytokine/index.html</a>
</div>
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