AɓIȃ^pN̂ɂזE̐@\

<strong>ɓ<sup>1</sup>Emq<sup>2</sup>Ecב<sup>3</sup></strong>
i<sup>1</sup>Éww@_w ZpȊwU񐧌䌤C<sup>2</sup>OOw_wȊw wȁC<sup>3</sup>Éww@w wUJmEZEoCIW[O[vj
emailF<a href="mailto:masakito@agr.nagoya-u.ac.jp">ɓ</a>
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̈Zr[, <strong>5</strong>, e005 (2016)@<a href="http://dx.doi.org/10.7875/leading.author.5.e005">DOI: 10.7875/leading.author.5.e005</a>
Masaki Ito, Michiko Sasabe & Yasunori Machida: <strong>Unique mechanisms of plant cell division regulated by multi-protein complexes.</strong>

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<h2>v </h2>
@A̍זE͎͂ɍזEǂƂCA͍זÊ߂ɓLȐ@\lDƂ킯CזEƍזEǂ̍\zɋNזÉCזE̌`܂ސAɓL̉ߒłDM҂́C̉ߒɕK{łAɌŗL̃LlVl^pNɂ萧䂳MAPLi[[JXP[h𔭌C̃JXP[h͍זEuɂĔǂ̓𐧌䂷邱ƂɂזE̌`𑣐i邱ƂDɁC̉ߒ܂ސAM̐isɂ`q̓]ʂɂ͓]ʈqƂR1R2R3^MybK{ł邱ƁCR1R2R3^Mybɂ͓]ʂ銈^Myb̂ق}^MybCÅ튯̔ɂזE̒~ɂdvł邱ƂoꂽDR1R2R3^MybG1/S̐ɏdvȓ]ʈqE2FƂƂɑ傫ȃ^pN̂`ĂCL͈͂ȋ@\S\̂邱Ƃ킩DMyb-E2F̂̍\^pNɂ́CɂčזEɂ`q̓]ʂ𕉂ɐ䂷DREAM̂̍\^pNƗގ镡̃^pN݂ĂƂCAɂĂCMyb-E2F̂זE̐ɂēl̋@\\lꂽD

<h2>͂߂</h2>
@זE͑BƂ̖{Iȑ̊błCɂƂƂdvȉߒ̂ЂƂłDזẺߒ́CזEƂ΂鐧䂳ꂽ̈ʑԂƂɂCꂽF̂ƍזE2̖זEɕz邵݂łD̂悤ȍזE̕qxɂ錤ɂ͂ɓэyꂪpC̐ʂĂ邪CMɂL􂠂邢͍זÊ݂ɂĂ͕sȓ_DAɂזĚi݁CDNA̕ȂǂɂG1/S`qƍזEȂǂɂG2/M`q̓]ʂIɕϓ邱<a href="#R1"><sup>1,2)</sup></a>CG1/S`q̓]ʂ̐ɂ́CƓlɁCE2F-DPweʑ̂SIȖS<a href="#R3"><sup>3)</sup></a> 킩ĂDCA̍זE͎͂זEǂɂ܂Ă邱ƂCזEɂ͐AɌŗL̉ߒƍlD܂CA̍זE͍זEǂ݂̑ɂړłȂƂCK؂Ȋ튯̌`̂߂ɂ͍זE̎ԓIȐ䂪dvłƂĂ<a href="#R4"><sup>4)</sup></a>D̂悤ȓAɂזÊ݂𖾂邱ƂɂCזE̋@\Ɋւ肢[邾łȂCVȕq̉ߒ𖾂\DM҂́CAɏœ_ڂCזE̕q̋@\эזEƕƂ̊֌WĂD
@M҂́C܂łɁC|{זEpɂCG2/M`q̃v[^[̈ɂ͋ʂ̃VXzłMSAz񂪑݂邱ƁCāC̔zɌ]ʈqłR1R2R3^MybɂG2/M`q̓]ʂ䂳邱ƂĂ<a href="#R5"><sup>5)</sup></a>D܂CR1R2R3^Mybɂ́CG2/M`q̓]ʂ銈^MybƁCtɁCG2/M`q}}^Myb݂邱ƂꂽD̒ḿCɂזĚɂēꂽ̂łDŋ߂ɂȂCVCkiYipɂC}^Myb͊튯̔ɂזE̓K؂Ȓ~ɋ@\邱Ƃ킩<a href="#R6"><sup>6)</sup></a>DɁCR1R2R3^MybG1/S̐ɏdvȓ]ʈqE2FƋʂ̃^pN̂Ɋ܂܂邱Ƃ킩CqgVEWEoGɂčזEɂ`q̓]ʐɒSIȂ͂炫傫ȃ^pN̂łDREAM<a href="#R7"><sup>7)</sup></a> Ƃ̋@\Iȗގl悤ɂȂDCזEɂẮC^pN̏C⑊ݍpȂǂ̍Iȓ]ʌ㐧䂪dvł邱Ƃ炩ɂĂDM҂́CAɌŗLȍזEłזE̌`̕q@\ɂČCAɂזEu̓Ԃт݂̊̂ɂĖ炩ɂ<a href="#R8"><sup>8,9)</sup></a>D܂C̉ߒɂIȃugtBbNɊւ錤i݁Cqxɂ闝ił<a href="#R10"><sup>10,11)</sup></a>D
@̃r[ɂẮCG2/M`q̓]ʂ̊ї}݂̂ɂďqׁCM̐iss邵݂̓T^ƂĐAɂזE̌`̐@\ɂĉDɁCŋ߂ɂȂ薾炩ɂꂽCAɂMyb-E2F̂̔ɂĉCɂގ̐DREAM̂Ƃ̊֘AC܂CA̔ɂזȆB̗}@\ɂċc_D

<h2>1DA̔|{זEɂG2/MɓٓIȓ]</h2>
@xȓ|{\ȃ^oRBY-2זEpMTCNR[h<em>CYCB1</em>`q̃v[^[ڍׂɉ͂ʁCG2/MɓٓIȓ]ʂ̊SVXzƂMSAz񂪓肳ꂽ<a href="#R12"><sup>12)</sup></a>DVCkiYiɂ͖180G2/M`q݂邪C̈`q̑͏㗬MSAz̃`[t݂邱ƂCMSAzG2/M`qʂɐ䂷VXzłƎvꂽ<a href="#R13"><sup>13)</sup></a>DMSAzɌ]ʈqyꃏnCubhnɂXN[jOʁC^oRMybłNtmybA2肳ꂽ<a href="#R14"><sup>14)</sup></a>D<em>CYCB1</em>`q̃v[^[ɑ΂ʂ𒲂ׂʁCNtmybA2MSAzɈˑIɓ]ʂ̊ɂ͂炭]ʈqł邱ƂꂽD
@MSAzɌR1R2R3^Myb́CAɑ݂R2R3^MybƂ͈قȂČ`qYƂĒmc-MybƂ悭DNAhC\CAɂc^MybƂ݂ȂĂ<a href="#R5"><sup>5)</sup></a>DR1R2R3^Myb͚MVEWEoGɂĂG2/M`q̐ɂ邱ƂĂCזEɂčL͈͂ɕۑꂽ]ʐoH`̂Ǝv<a href="#R15"><sup>15,16)</sup></a>D

<h2>2DG2/M`q̓]ʂR1R2R3^Myb</h2>
@VCkiYĩQmɂR1R2R3^MybR[h5̈`q݂Ĉ<em>MYB3R1</em>`q<em>MYB3R4</em>`q̓^oR̓]ʈqNtmybA2Ƃ悭A~m_zR[hĂD<em>MYB3R1</em>`q<em>MYB3R4</em>`q𓯎ɔj󂵂AɂĂ͑G2/M`q̔ቺĂƂCMYB3R1MYB3R4̓VCkiYiɂē]ʂ̊ɂ͂炭]ʈqƂċ@\CG2/M`qʂɐ䂷̂ƍlꂽ<a href="#R13"><sup>13,17)</sup></a>D܂CMYB3R4͕gD⑝B̎Ⴂ튯ɂG2/M̍זEɓٓIɔĂCꎩ̂זEɂĐĂDāC犈^Myb̂͂炫́CMs邽߂G2/M`q̔זE̓̃^C~OɂăIɂ邱Ƃłƍlꂽ<a href="#R14"><sup>14,17)</sup></a>D
@^Myb͍זEɂēd̃tB[hobN[vɂ萧䂳D1ڂ̃tB[hobN[v́C^MybMTCNˑLi[[̊ɂ蒼ڂ̃_邱ƂłD^oRBY-2זEɂMTCNߓIɔƁC^Myb̓]ʊ\債DMTCNR[h`q͊^Myb̕WIł邱ƂC^MybMTCNƂ̂ɂ͐̃tB[hobN[v<a href="#R18"><sup>18)</sup></a>D2ڂ̃tB[hobN[v́C^MybR[h`q̏㗬MSAz񂪑݂Cꎩ̂R[h^pNɂ]ʊ邱Ƃł<a href="#R19"><sup>19)</sup></a>D̂悤ȓd̃tB[hobNG2/M`q̃o[XgIȔ̏㏸ЂNCG2Mւ̕stIȐiÂƍli<a href="#F1">}1</a>jDɂẮĈ悤Ȑ̃tB[hobNƂāCTCNˑLi[[ɂ郊_zXt@^[[CDC25TCNˑLi[[E_邵݂񏥂Ă<a href="#R20"><sup>20)</sup></a>D^MybɂtB[hobŃCCDC25̃zOȂA֓IɊlM̊Jn݂̂Ȃ̂ȂD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@Å튯̔ɂ銈^Mybї}^Myb̂͂炫</strong>
BĂזEɂẮC^MybƗ}^Myb͓זEɂēɊċ邱Ƃ͂ȂCG2̂^C~OɂāC}^Myb犈^MybւƃXCb`ƍlD^Myb́Cꎩ̂R[h`q̓]ʊCWI`qłMTCNR[h`q̓]ʊd̃tB[hobN[vɂCɐ䂳ĂD̐i񂾊튯̕זEɂẮCG2/M`q̓]ʗ}̏Ԃ}^Myb̂͂炫ɂێĂD
CDKFTCNˑLi[[CPF_D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/05/Machida-5.e005-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2016/05/Machida-5.e005-Fig.1.png&amp;caption=fig1-caption-text]

@VCkiYiɂMYB3R1MYB3R4̋@\IɌψّ̂ł́Cr؂ꂽזEǂ⑽j̍זEpxŏoȂǁCsSȍזEɂ萶T^IȈُ킪ώ@ꂽ<a href="#R17"><sup>17)</sup></a>DVCkiYi̍זEɕK{Ȉ`qƂčŏɓ肳ꂽ<em>KNOLLE</em>`qG2/MɓٓIɔCזE̌`̍ۂ̏EZɂSNARE^pNR[h<a href="#R21"><sup>21)</sup></a>D<em>KNOLLE</em>`q̃v[^[͕MSAzC|[^[AbZCɂMSAzɈˑIĊ^Mybɂ]ʊ<a href="#R17"><sup>17)</sup></a>D܂C<em>KNOLLE</em>`q̔͊^Myb𕔕IɌAɂĂ͒ቺĂC̐Aɂ<em>KNOLLE</em>`qߏɔƍזEɊւ\^̂قƂǂ񕜂ƂC<em>KNOLLE</em>`qMYB3R1MYB3R4̉ɂčזE̐ɂ͂炭ƂȂWI`qł<a href="#R17"><sup>17)</sup></a>D^Myb̕ψّ̂ɂ`q̔ԗIɉ͂ʁCMYB3R1MYB3R4ɂ]ʊ̕WI`qɂ́C<em>KNOLLE</em>`q̂قɂזEɊ֘A镡̈`q܂܂邱Ƃ킩<a href="#R13"><sup>13,17)</sup></a>DƂ΁CtOvXg̐ɂǌ^pNMAP65CזE\鑽̍Ɋ֗^Z[Xyfގ^pNGh^1,4OJi[[Ȃǂ̂قCMɓٓIȑ̃LlVl^pNȂǂR[h`qłD̂悤ɁC^MybWI`q̓]ʐזE̐is邵݂炩ɂꂽD

<h2>3DAɂזE̐@\</h2>
@ł́CR1R2R3^Myb̉ɂ鎖ۂƂčזEƂ肠CזE̌`ɕK{ȓ]ʌ㐧nCсC̐ɂMybWI`q̊֗^ɂĉDזÉCꂽF̂ƍזE2̖זEɕMɂŌ̉ߒłD̍זE͊Oւ̊דɂЂN̂ɑ΂āCA̍זE͍זEƍזEǂȂזEזE̓Oɂނ`邱ƂɂN<a href="#R22"><sup>22-24)</sup></a>i<a href="#F2">}2a</a>jD̂悤ȓIȎۂ́CɂẮCʂɌ`~IVIIуAN`tBgȂkƁCF̂̂Ɍ`ZgXsh邢̓~bh{fBƂ΂זEuɂsDCAɂזÉCꂽF̂̂Ɍ`tOvXgƂ΂זEuɂĐisDZgXshƃtOvXg͂ɐ2̋ȔǑƃAN`tBgȂ\̂ŁC2̔Ǒ݂͌ɃvX[łނi<a href="#F2">}2b</a>jDŏCtOvXg͓܂Ŕǂ܂\Ă邪CCזE`ƍזEƂ܂悤ȃO̍\ƂȂCזE̌`ƂȂȂ牓SIɊg債זEǂ܂œBDזE̌`ʂłtOvXg̐ԓʂɂ́CgXSWlbg[N邢͏Gh\[ɗR鏬E~ςėZi<a href="#F2">}2b</a>jCZ\̂ɂčזEǂ̐邱ƂɂזE̌`ъg傪iށD̂悤ɁCA̍זÉCǂ̃_Ci~NXbƂtOvXǧ`ƊgCсCtOvXgɂ鏬E̗AƗZbƂזE̌`CƂ2̉ߒȂD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@זEɂ邳܂܂ȃCxg</strong>
iajAƓƂ̍זE̔rDAɂẮCtOvXgɂČ`זE̊gɂזE񕪂DɂẮCkуZgXshɂOɂނזEт邱ƂɂזE񕪂D
ibjזE̌`ɂtOvXgł̔ǂ̖ƏEAnDtOvXg̔ǑɂāCgXSWlbg[N邢͏Gh\[ɗR鏬EזEʂɗACꂪZčזE`D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/05/Machida-5.e005-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2016/05/Machida-5.e005-Fig.2.png&amp;caption=fig2-caption-text]

@tOvXgɂǑ̃_Ci~NX͍זE̌`̌͂łDtOvXǧ`̊Jn݂͖̂𖾂ł邪CtOvXg̊gɂ̓I[O~-`[ûɂVKȔǂ̌`̂邱Ƃ炩ɂꂽ<a href="#R25"><sup>25,26)</sup></a>DtOvXg͈ȔǑƓIŕsȔǂɂ\CȔǑ̃`[ujƂVKŕsȔǂ̌`ƁC̑ɂ艻CƂԂɂtOvXgg傷ƒ񏥂Ăi<a href="#F2">}2b</a>jD
@M҂́C^oRBY-2זEpwIэזEwIȉ́CсCVCkiYipq`wIȉ͂gݍ킹CLlVl^pNłNACK1ɂ芈MAPLi[[JXP[hA̍זEɂĒSIȖ͂Ƃ𖾂炩ɂi<a href="#F3">}3a</a>jDɁC̃JXP[hM̐is̉ߒɂăTCNˑLi[[ƃTCNBƂ̂̕ɂ}Iɐ䂳邱ƁC̉ɂĂ͔ǌ^pN̋@\̐ƂtOvXgɂĔǑ̕s艻ЂNꂻ̊g傪iĂ邱ƂꂽD̉ߒɂ`q̑͂ɏqׂ悤ȓ]ʐ邪C獇ꂽ^pN͈ȉɏqׂ悤ȍIȓ]ʌ㐧זE̌`BD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@A̍זE𐧌䂷NACK-PQRoH</strong>
iaj^oRɂNACK-PQRoHɂזE̐Dl̐n̓VCkiYiɂ݂D
ibjזE̍ۂNACK-PQRoH̍\^pN̍זEǍ݁DNACK1MAPLi[[JXP[h̍\^pNׂ͂ătOvXg̐ԓʁCȂ킿CזE̌`ʂɃOɋǍ݂D
icjM̐isɂTCNˑLi[[-TCNB̂ɂNACK-PQRoH̊̐DM̑OɂNACK1NPK1͏\ɒ~ςĂ邪CTCNˑLi[[ɂ郊_ɂ肻̑ݍp͑jQNACK-PQRoH͊ȂDM̌ɂȂƁCTCNBăTCNˑLi[[̊ቺC̃zXt@^[[ɂNACK1NPK1͒E_NACK1NPK1Ƃ͒ڂɌ悤ɂȂNACK-PQRoH͊D
CDKFTCNˑLi[[CPF_D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/05/Machida-5.e005-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2016/05/Machida-5.e005-Fig.3.png&amp;caption=fig3-caption-text]

@^oRɂāCMAPLi[[JXP[h̍ŏʂɈʒûMAPLi[[Li[[Li[[łNPK1ł<a href="#R27"><sup>27,28)</sup></a>CNACK1Ƃ̌ɂ芈<a href="#R29"><sup>29)</sup></a>i<a href="#F3">}3a</a>jDNPK1NACK1͍זE̌`ʂłtOvXg̐ԓʂɋǍ݂i<a href="#F3">}3b</a>jDNPK1̉ɂẮCMAPLi[[Li[[łNQK1/NtMEK1CсCMAPLi[[łNRK1/NTF6@\i<a href="#F3">}3a</a>jDNPK1NQK1NQK1NRK1́CꂼCړIɑݍpĉ̃Li[[_CJXP[h̑Ŝꂽ<a href="#R30"><sup>30)</sup></a>D̃^pNׂ͂ătOvXg̐ԓʂɋǍ݂C̃h~iglKeBuψّ̂𔭌ƕsSȍזE̒~ρCjCזEȂǂ̍זE̕sSD̃JXP[h̓VCkiYiɂĂۑĂ<a href="#R30"><sup>30-34)</sup></a>C̕ψׂّ̂͂čזE̕sS̕\^D̂悤ɁC^oRуVCkiYiɂĂ͗ގMAPLi[[JXP[hזEɂDɂĂCERK1ERK2ZgXshɋǍ݂<a href="#R35"><sup>35-37)</sup></a>CזĚɂċ@\ƍlĂ<a href="#R38"><sup>38)</sup></a>D
@VCkiYiɂNACK1̃zOR[h<em>AtNACK1</em>`q<em>AtNACK2</em>`q́CꂼCזE̕sSψّ̂瓯肳ꂽ<em>HINKEL</em>`q<em>TETRASPORE/STUD</em>`qƓł<a href="#R29"><sup>29,39,40)</sup></a>D<em>HINKEL/AtNACK1</em>`q<em>TETRASPORE/STUD/AtNACK2</em>`q̕ψّ̂́CꂼC̍זËُ킨щԕ̌`ُ̈C̓dψّ͔̂z̒vł<a href="#R41"><sup>41)</sup></a>D͏d@\CA̍זEɂĕK{łDNACK1NPK1Ȃǂ邾łȂCtOvXg̐ԓʂɃN[g<a href="#R29"><sup>29)</sup></a>D̂悤ɁCNACK1NPK1͍̌זĚƂȂ锽ƂDM҂́CMAPLi[[JXP[h𒆐SƂoHNACK-PQRoHƖ<a href="#R30"><sup>30)</sup></a>i<a href="#F3">}3a</a>jD
@NACK-PQRoH̊CDKTCNˑLi[[ɂ蕉ɐ䂳Ă<a href="#R8"><sup>8)</sup></a>i<a href="#F3">}3c</a>jDNACK1Mɒ~ςCMAPLi[[JXP[h\^pN͂ȑO瑶݂CM̑Oɒ~ϗʂ㏸DCNPK1͂߂Ƃ3̃Li[[̊M̒̂̂͂߂ċN<a href="#R29"><sup>29,30)</sup></a>DM̑O璆ɂẮCTCNˑLi[[-TCNB̂ɂNACK1NPK1_ꂻ̌jQĂ邩łDM̒̂̂TCNBTCNˑLi[[̊ቺƁCNACK1NPK1݂͂₩ɒE_C݂ɌNPK1̃Li[[CtOvXg̊g储эזE̌`N<a href="#R8"><sup>8)</sup></a>D̂悤ɁCNACK-PQRoH̊M̐is̉ߒɂČɐ䂳ĂD
@MAPLi[[łNRK1̉̃^pN̐wIȉ͂Cǌ^pN̂ЂƂłMAP65NRK1ɂ胊_邱Ƃ킩<a href="#R42"><sup>42,43)</sup></a>DMAP65́CqgłPRC1CoyłAse1Ƃ΂CזEɕK{łTCNˑLi[[ɂ郊_̐<a href="#R44"><sup>44-46)</sup></a>DMAP65͔ǂ𑩉銈CMAPLi[[ɂMAP65̃_<em>in vitro</em>ɂĔǂ̑̊}D܂CMAPLi[[񃊃_ψٌ^MAP65^oRBY-2זEɂĉߏɔƔǂ̈萫㏸CtOvXg̊g傪邵xĎʂ́CNRK1MAP65_C̑}邱ƂɂtOvXg̊g𑣐i邱ƂĂ<a href="#R42"><sup>42)</sup></a>D
@VCkiYiɂזE̌`ɂẮCgXSWlbg[N邢͏Gh\[ɗR鏬Ei<a href="#F2">}2b</a>jD͓̃|XgSWAoHւčזEւƗAƂĂ<a href="#R47"><sup>47-49)</sup></a>D̏E͍זEʂɂSNARE^pNėZCזE̌`ɂDSNARE^pN݂SNAREhCđݍpCugtBbNoHƂɓٓIȕ̂`ċ@\<a href="#R11"><sup>11)</sup></a>DR1R2R3^Myb̕WIł<em>KNOLLE/SYP111</em>`q͍זE̌`ɕK{SNARE^pN̂ЂƂR[h<a href="#R21"><sup>21,50)</sup></a>D܂CזEɈُψّ̂ɂČ^pNƂē肳ꂽKEULÉCKNOLLEƌSNARÊ̌`𑣐i<a href="#R51"><sup>51)</sup></a>Dŋ߁CgXSWlbg[N邢͏Gh\[ɗR|XgSWAoH番傳זE̌`ɂċ@\鏬Ě`ɂ^pNƂBIG1CBIG2CBIG3CBIG4񍐂ꂽ<a href="#R10"><sup>10)</sup></a>D̂悤ɁCזE̌`ɂċ@\鏬Ě`Zɂ^pN炩ɂĂCtOvXgɂEÂ݂⏬E̐ς݉׃^pNɂĂ͕sȓ_DM҂́CזE̌`ɂ͂炭Ȃ炩̃^pN̗ANACK1\ɂČĂ<a href="#R52"><sup>52)</sup></a>D

<h2>4D]ʂ̗}ɂ͂炭R1R2R3^Myb̔Ƃ̋@\</h2>
@VCkiYiɑ݂5R1R2R3^Mybɂ́CMYB3R1MYB3R4̂悤Ȋ^Mybł͂ȂC]ʂ̗}ɂ͂炭}^Myb݂邱Ƃ炩ɂꂽ<a href="#R6"><sup>6)</sup></a>DR1R2R3^MybR[h`q܂܂ȑgŔj󂵂dψّ̂oƂCA~m_ẑ悭MYB3R3MYB3R5ɔj󂳂G2/M`q̔㏸<a href="#R6"><sup>6)</sup></a>D̕ψق͂ɏqׂ^Myb̕ψّ̂ɂ݂ꂽُ𑣐iȂƂC͂ς}Iɂ͂炭]ʈqłƍlꂽDG2/M`q̃v[^[̊}^Myb̕ψّ̂ɂĒׂC}^Myb̌ʂMSAzɈˑĂ邱Ƃ킩DMyb͈ʂɓ]ʂ]ʈqłƂ݂ȂĂĈ݂ƂC^MybƗ}^Mybɑ݂邱ƂmĂ̂̓VCkiYił<a href="#R6"><sup>6,53)</sup></a>DVCkiYiɂ}^Myb̈`qj󊔂ڍׂɉ͂ʁCȉɎ悤ɁC}^Myb͑BĂזEƑB~זE̗ɂċ@\Ă邱Ƃ킩<a href="#R6"><sup>6)</sup></a>D
@BĂזE𑽂܂ރVCkiYi̕gDC邢́C̏̎X̊튯ɂẮC<em>CYCB1</em>`qG2/M̍זEɂ邽߁Cu^pNɂW1זEƂ̃pb`̔p^[DC}^Myb̕ψّ̂ɂĂ<em>CYCB1</em>`qזẼXe[WɈˑɔ錋ʁCgD̍זElɌu悤ɂȂD̂ƂCBĂזEɂ}^Myb̋@\́CG2/MȊO̎ɂē]ʂ}邱ƂɂCWI`q鎞זE̓̃Xe[WɌ肷邱Ƃłƍlꂽi<a href="#F1">}1</a>jD^Myb邢͗}^Myb̕ψّ̂ꂼ̕\^́Cψقgݍ킹ƂɑIɌC݂̕ψق̌ʂł悤ȍp͎Ȃ<a href="#R6"><sup>6,53)</sup></a>D̂ƂC^MybƗ}^Myb͓זEœɊċ̂ł͂ȂC^MybƗ}^MybזEɂČ݂Ɋ悤Ȑ؂ւ\ɂ関m݂݂̂ƍli<a href="#F1">}1</a>jD
@CB~זEɂ}^Myb̂͂炫ƂĖ炩ɂꂽ̂́Ci邢́CjזEɂ]ʗ}̊mт̈ێłDʏCזE~čŏIIɕזEɂĂG2/M`q̔͂قƂǔF߂ȂC}^Mybψّ̂ɂĂ͂łɕi邢́C~ĕNߒɂjזEG2/M`q̔pĂ܂CߏȐُIȍזE􂪐<a href="#R6"><sup>6)</sup></a>ĎʂCiݍזE~זEɂẮCG2/M`q̓]ʂȂł͂ȂCϋɓIɓ]ʂ}邵݂݂Ă邱ƂD̂悤ɁC̐isɂƂȂG2/M`q̓]ʂ̗}ɂė}^MybvȖSĂi<a href="#F1">}1</a>jCꂪA̔̉ߒɂ鎞ԓIȍזE̐ɏdvȈӖƂꂽD܂CG2/M`q̔ɑ΂}^Myb̌ʂ́CׂׂĂ̊튯gDɂđSgIɂ݂ꂽƂCÅ튯ɂĈʓIɂזE̐̕𔽉fĂ̂ƍlD

<h2>5DVCkiYiɂMyb-E2F̂̔DREAM̂Ƃ̗ގ</h2>
@~x~Ԃ̓זEɂāCזEɊ֘A`q̓]ʂ}^pN݂̂̑炩ɂĂ<a href="#R7"><sup>7)</sup></a>D\^pNȂǂɑ̈Ⴂ͂邪CqgCVEWEoGCɋʂɑ݂傫ȃ^pN̂łCꂼɈقȂ閼̂Ă邪Cł́ĈDREAM̂ƂԁDVEWEoGɂĐwIɓ肳ꂽDREAM̂̑傫ȓ́C]ʈqE2Fił́CE2F2jMyb^pN̂ɑ݂邱Ƃł<a href="#R54"><sup>54,55)</sup></a>i<a href="#F4">}4a</a>jDqgDREAM̂̏ꍇɂ́CMybE2Fił́CB-MybE2F4/5j^pN̂ɓɑ݂邱Ƃ͂ȂC͍זËقȂɋʂ̃RÂƌCقȂ\^pNDREAM̂Ƃđ݂<a href="#R56"><sup>56)</sup></a>i<a href="#F4">}4a</a>jDDREAM̂̋ʂ̋@\͍זEɊ֘A`q̓]ʂ}邱ƂłCMyb̖DREAM̂ɂ]ʂ̗}邱ƂłƍlĂDqgDREAM̂͑B~x~Ԃ̍זEɂāCG1/S`qG2/M`q̓]ʂ}Ă<a href="#R57"><sup>57)</sup></a>DזEB̎hSɂނߒɂāCRÂɑ݂^pNE2F4/5B-MybɌĈ̂CB-Myb̓tH[Nwbh^]ʈqFoxM1N[gG2/M`q̓]ʂ<a href="#R56"><sup>56)</sup></a>i<a href="#F4">}4a</a>jD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@DREAM̂̍\^pN</strong>
iajqgуVEWEoGɂĐwIɓ肳ꂽDREAḾDʂ̃RÂE2FMybȂǂ̓]ʈqĂDqgɂẮCBĂזEƑB~זEƂō\^pNقȂDVEWEoGɂẮCBĂזEɂMybE2F̂ɑ݂D
ibjVCkiYiɂė\zMyb-E2F́DVCkiYiɂ́CE2FBMYB3R4܂ފ^Myb-E2F̂ƁCE2FCMYB3R3܂ޗ}^Myb-E2F̂C}^Myb-E2F͔̂iމߒɂč\^pNωD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/05/Machida-5.e005-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2016/05/Machida-5.e005-Fig.4.png&amp;caption=fig4-caption-text]

@AɂāCB~gDɂ}^Myb̖͓DREAM̂ɂ͂炫zN̂ł<a href="#R6"><sup>6,58)</sup></a>DVCkiYiɂė}^Myb`qN}`Ɖu~@ɂ蒲ׂʁCG2/M`qƓɁC]ʈqE2F̕WIƂȂ鑽̈`q}^MybƋaDNAfЂƂē肳ꂽ<a href="#R6"><sup>6)</sup></a>ĎʂC<em>in vivo</em>ɂāC}^MybE2FƂ̂ɒڂ邢͊Ԑڂ̑ݍpCMyb-E2F̂MybE2FDNÄG2/M`qG1/S`q̗Ɍ̂ł͂ȂƍlꂽDwIɒׂƂCMybE2F͕̂`ĂCɁCقɂDREAM̂̍̕\^pÑzO܂܂\ꂽ<a href="#R6"><sup>6,53)</sup></a>DŁCAɓLȍ\^pŇƂāCTCNˑLi[[̈킪Ɖu~ɂ茟oĂD܂CqgCVEWEoGCɂĕۑĂDREAM̂̍\^pNłLIN37/Mip40LIN52͐Aɂ̓zOȂƁC܂CqgɂDREAM̂ɃN[gtH[Nwbh^]ʈqɑΉ]ʈqt@~[͐Aɂ݂͑ȂƂȂǂCAɂMyb-E2F̂̍\^pŃCDREAM̂̍\^pNƂ͂ȂقȂƍlD
@VCkiYiɂāC^Myb܂Myb-E2F̂Ɨ}^Myb܂Myb-E2F̂́C]ʈqE2F̈قȂ镪q܂łDVCkiYiE2Fɂ́C]ʂ̊ɂ͂炭E2FAE2FBƁC]ʂ̗}ɂ͂炭E2FC݂<a href="#R3"><sup>3)</sup></a>D̂̉͂̌ʁC}^MybE2FCƁC܂C^MybE2FBƁCꂼCƗMyb-E2F̂`邱Ƃ\zꂽ<a href="#R6"><sup>6,53)</sup></a>i<a href="#F4">}4b</a>jDVCkiYiMyb-E2F̂͊튯̔̉ߒɂč\^pNωĂ悤DBĂזE𑽂܂ޏ̃Xe[W̗tɂẮC}^MybRBR܂Myb-E2F̂ɑ݂邪CE2FC݂͑ȂDCזEB~̃Xe[WɂẮCRBRłȂE2FC}^MybƋa<a href="#R6"><sup>6)</sup></a>i<a href="#F4">}4b</a>jDVCkiYiMyb-E2F̂́CqgDREAM̂̂悤ɁC\^pN̕ωƂȂȂCזE┭̉ߒɂĂ̂͂炫_Ci~bNɕωĂ̂ł͂ȂƍlDM҂́CMyb-E2Fׂ̂̂Ă̍\^pN₻̓Ԃ̑Se𖾂炩ɂׂĂDDREAM̂ɂ͖𖾂ȕcĂCMyb-E2F̂̌CAɓL̐@\DREAM̂̐iIȕۑȂǂɂĐVm̓邱Ƃ҂D

<h2></h2>
@̃r[ɂẮCŋ߂ɂȂ薾炩ɂꂽC^pN̂ɂAɂזE݂̐̂Ɋւ2̗ɂĉDЂƂ́CVCkiYiɂMyb-E2F̂ɂ]ʐłDMyb-E2F̂̍\^pNWIDNAƂ̌זE튯̔̃Xe[WɈˑĂǂ̂悤ɕω̂C܂C\^pN̂ɂ͂ǂ̂悤ȋ@\Iȑݍp̂ȂǁC̉ۑ肪cĂDזE𐧌䂷MybE2FƂ2̎vȓ]ʈq^pN̂ɑ݂邱Ƃ̐IȈӋ`Ȃǂɂė̐iނƂ҂DЂƂ́CLlVl^pNłNACK1MAPLi[[JXP[h̍\^pNƂ̂̕ɂזE̐łD̃^pN̂͋Ȕǂ̍\̂łtOvXgɑ݂CŔǂ̓Ԃ𐧌䂷邱ƂɂזE̌`𐧌䂷D̃^pN̂̌́CזĚɂÂ̖łCזEƍזEǂ̍\zєǂ̐ƂȔ̓̉𖾂ɂȂ\DMAPLi[[̐VȊNACK1̖m̐ς݉׃^pNɊւ錤́Ĉ悤Ȃ݂̗ɓJƊ҂DCזEɂẮĈ̂̉ߒ̏I̉ߒ̊JñVOiɂȂƂlƁCזE̊ɂG1̊JnG0ւ̈ڍs𐧌䂷\DCꂽ悤ȐA̍זE𐧌䂷錮ƂȂ^pN̂𒆐SƂāCזExь̃xł̌i߂邱ƂɂCAɓLȍזEь̂̌`̐n𖾂D

<h2> </h2>
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</ol>
<div class="au-profile">
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<span class="author">ɓ iMasaki Itoj</span>
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