A̐BߒɂGsWFleBbNȏ̃vO~O

<strong>؉  N</strong>
iޗǐ[ȊwZpw@woCITCGX AB`w`[j
emailF<a href="mailto:t-kinosita@bs.naist.jp">؉ N</a>
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̈Zr[, <strong>2</strong>, e001 (2013)@<a href="http://dx.doi.org/10.7875/leading.author.2.e001">DOI: 10.7875/leading.author.2.e001</a>
Tetsu Kinoshita: <strong>Epigenetic reprograming of maternal and paternal genomes during plant sexual reproduction.</strong>

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<h2>v </h2>
@ߔÑGsWFleBNX̌̐iɂCDNAzȊȌ񂪈`ƂĂ͂炢Ă邱Ƃւ̗͋}ɐi񂾁DȂC̑Se͈ˑRƂčׂƂĂČ҂𖣘fĂ܂ȂDł́C̐ۂ̂ȂłCGsWFleBNXƂƂɊ֘A̐[A̐BߒƂ肠DA̕GȐBߒɂāCǂ̂悤ȕq@\ɂGsWFleBbNȏ񂪐䂳Ă̂C̐wIȈӋ`l@D

<h2>͂߂</h2>
@gȏt̋G߂ɂȂƁC̑Ԃ̖ڂy܂ĂDŁCAɂƂĉԂ炩邱Ƃ́C̐֎qc߂̏dvȉĉ݂ЂƂłD̂悤ȐA̐Bߒł́CׂƂ߂ׂ̑ݍpɂC̃ACfeBeB̈ێCWcɂ鑽l̈ێɊւāCׂ_Ci~bNȂ߂NĂDGsWFleBbNȏ܂߂`ǂ̂悤Ɂgh`B邩C邢́Cge͈͓hł̕ω`̂C܂ČʁCǂ̂悤Ȍ⑽lt^̂C͂܂ĈԂ̂͂ĂɐA̐iɑ΂ǂ̂悤ȉêC̏ڍׂ͂قƂǖ炩ɂȂĂȂD̐iɂCDNÃ`CqXg̏CCᕪqRNAȂǁCDNẢzȊÕGsWFleBbNȏ񂻂̂̂ɑ΂闝͐[܂C̏񂪐BߒɂĂǂ̂悤ɃvO~OiĵĆ݂CVȒmƕ񍐂悤ɂȂiKł<a href="#R1"><sup>1,2)</sup></a>D
@ʓIȐADNA`ɊւĂ͂قɏڍׂȑ邽<a href="#R3"><sup>3)</sup></a>Cł͊ȒPɏqׂɂƂǂ߂邪CAɂ3̃JeS[DNA`ʂ݂Dŋ߂ł́CMłESזEȂǂꕔ̍זEɂCpGzȊO̔złDNA`݂Ă邪CAł͑̏ꍇCCpGẑقCCpHpGz񂨂CpHpHziH = CCTCAj̃VgV5ʂɃ`t5-`VgVƂȂDVCkiYił́CCpGz͂DNAɂƂȂDNÂ݂`w~`ʂɂĈێ^DNA`yfMET1ɂ胁`DCpHpGz̓qXgH39Ԗڂ̃Wc̃`SqXg`yfKYP̂͂炫ɈˑĐAɓٓIȃN`yfCMT3ɂ胁`DCpHpHzRdDMiRNA-directed DNA methylationCRNAw^DNA`j̋@\ɂᕪqRNA<em>de novo</em>^`yfDRMɂ胁`<a href="#R3"><sup>3)</sup></a>D
@A̐BߒɂGsWFleBbNȏCƂ킯CDNÃ`ǂ̂悤ɐ䂳邩𗝉ɂẮCqȀd󐸂݂̂𗝉邱ƂK{łDāC܂CŌɎQl}ƂĂCgRN: A̐BזEƎ󐸐헪. <a href="http://leading.lifesciencedb.jp/1-e007/" target="_blank">̈Zr[, <strong>1</strong>, e007 (2012)</a>hnǂĂقD܂CRdDM̋@\ɊւĂCł͎ʂ̓s炭킵͉Ȃ̂ŁC̎Ql}CgAɂRNATCVO@\hnǂĂقD̂ŁCA̐BߒɂẮCY̔źC󐸌󔭐ɂāCGsWFleBbNȏ񂪐䂳ꃊvO~O邱Ƃɗi߂ĂقDȉC݁C炩ɂȂCA̐BߒɂGsWFleBbNȐɉ.

<h2>1DẑɂeɗRQm̃GsWFleBbNȐ</h2>
@ẑ́C߂ׂ̉[ɑ݂gDɂāCEqזĚ̂̂1cEq3̔̂̑̍זEւ邱ƂŐnD̔qÁCזECזEC2̏זEC3̔זE8j7זEȂCXiembryo sacjƂ΂i<a href="#F1">}1</a>jD̂Cԕɂ^΂Ă2̐זEƂ̎󐸂ɂ̂͗זEƒזEłCꂼ`D̍זÊCזEɂĂƂDNA`ɂGsWFleBbNȏ̕ω݂邱ƂmĂ<a href="#R4"><sup>4,5)</sup></a>D

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@ẑ̌`ߒ</strong>
ẑ́CEqזĚC@\IȑEq3̑̍זEւČ`DזEɂĂDNAE`yf̈`qĂCCvg`qȂǂWIƂDNAE`NƍlĂDYẑƈقȂCẑ̂ꂼ̍זȆʕ͂܂ĂȂDȂC`wIȉ͂Ȃт敪p͂ɂCזEɂDNAE`C24̒ᕪqRNA̎YoƗזE邢ւ̈ڍsCWIzRdDM@\ɂDNA`̃f񏥂ĂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Kinoshita-2.e001-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2013/01/Kinoshita-2.e001-Fig.1.png&amp;caption=fig1-caption-text]

@זEɂGsWFleBbNȐ̌̔[ƂȂ̂́CCvg`qƂ<em>MEDEA</em>i<em>MEA</em>j`q̔ł<a href="#R6"><sup>6,7)</sup></a>DCvg`q́C̑Η`qeReRɉĈ`q̃IEIt肳D̂悤Ȍۂ͂ɚMƔqAɂĂ݂ĂCQmCveBOƂ΂Ă<a href="#R8"><sup>8)</sup></a>D<em>MEA</em>`qC@\mHD-ZIP^̓]ʈqR[h<em>FWA</em>`qȂǂ̃Cvg`q́C<em>DEMETER</em>i<em>DME</em>j`qɃR[hDNAE`yfɂC󐸑O̎ẑ̒זEɂDNAE`C`qU<a href="#R9"><sup>9,10)</sup></a>i<a href="#F2">}2</a>jDŋ߂ł́C<em>MEA</em>`qɊւĂDNAE`̂قɂN}`̃[v\GsWFleBbNȐ̂邱ƂfƂĒ񏥂Ă<a href="#R11"><sup>11)</sup></a>Dɂ́C}EXƓlɁCV[NGT[pSNPisingle nucleotide polymorphismCꉖ^j̉͂CeɗRΗ`q邢͕eɗRΗ`qɓٓIɔCvg`q̑̌₪݂ĂĂ<a href="#R12"><sup>12)</sup></a>DẤCCvg`q̓VCkiYipψّ̂̌ɂ蔭ĂDVCkiYił́C|R[̂̍\^pNR[h<em>MEA</em>`q<em>FIS2</em>i<em>Fertilization-Independent-Seed</em>j`qɃQmCveBO݂ĂD܂C`q͈قȂĂ̂́CPqtAёoqtAɂă|R[̍\^pNR[h`q̂ǂꂩQmCveBOĂ߁CMєqAɂCvg`q́CiIȑǏʂƂĐƂRtNg<a href="#R13"><sup>13,14)</sup></a> xĂDȂCV[PT[p͂̌ʂ́CClCVCkiYiCgERV̂ŋقǂ̑l<a href="#R12"><sup>12)</sup></a>DCvg`qǂ̂悤ɐẮCC؂Kv邪CɂCA̐BߒɂGsWFleBbNȐ́CCvg`q̉͂fƂė悤ɂȂĂƂĂߌł͂Ȃ낤D

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@VCkiYi<em>FWA</em>`qɂQmCveBO̐@\</strong>
ẑ̒זEł̓Cvg`qł<em>FWA</em>`q5f̗̈̔zɂDNAE`NC`qUDYẑ̑ł͈ێ^DNA`yfɂDNA`͈̏ێĂDYƂ󐸑Ȍ񂪎󐸌gDɃGsWFleBbNɓ`BCeɗRΗ`qɓٓIȈ`qώ@DȂCזEł<em>FWA</em>`q̊͋NȂ߁Cł͕eѕeɗRΗ`q͂Ƃɔ}ĂD
MeF5-`VgVD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Kinoshita-2.e001-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2013/01/Kinoshita-2.e001-Fig.2.png&amp;caption=fig2-caption-text]



<h2>2D\IDNAE`̋@\</h2>
@DNẢߒł5-`VgV͖DNAɎ荞܂Ȃ߁CDNA`̈ێ@\͂炩ȂꍇɂDNAɂƂȂDNA`͌ĂD󓮓IDNAE`ipassive DNA demethylationjƂԁDCDNAɈˑ`ϋɓIɎ菜@\݂D\IDNAE`iactive DNA demethylationjƂԁD
@VCkiYiɂ<em>DME</em>`q̕ψّ̂̒PƁĈ̂́g\IȁhDNAE`yfƂĂDMĚ́CA̐BߒɂGsWFleBbNȃvO~Om邤łЂƂ̓˔jƂȂ<a href="#R15"><sup>15)</sup></a>D܂CMɂDNAE`̌ɂȉeyڂ<a href="#R16"><sup>16,17)</sup></a>D<em>DME</em>`q͔rI傫ȃ^pNR[h邪CC[ɉCɂDNAORV[[Ƃ悭hC\<a href="#R18"><sup>18)</sup></a>DVCkiYiɂĂ4̃zOC<em>DME</em>`qC<em>DML2</em>`qC<em>DML3</em>`qC<em>ROS1</em>`q݂<a href="#R16"><sup>16)</sup></a>D̂CזEɂĒSIȖ͂Ă̂<em>DME</em>`qł<a href="#R19"><sup>19)</sup></a>DPqtAłClɂĂC`q^[QeBO̎@p<em>OsROS1a</em>`qj󂷂ƁCBߒɃVrAȉe̐邱ƂĂ<a href="#R20"><sup>20)</sup></a>DDME͂߁C̃^pNɃhC\Ƃđ݂DNAORV[[́C̐C@\ɂĂ͂炭yfƂĒmĂDC@\ł́C܂G/TȂǃ~X}b`̔FƂ̐؂oNCkNI`hi̐ؒfCCDNA̍DNAK[[ɂMbv̏CNCDNAC͊DVCkiYiɂROS1DME̐wIȉ͂̌ʁC̃^pN̓OAj5-`VgVƂ̃yA~X}b`yÂ悤ɔFC5-`VgV̐؂oƃkNI`hi̐ؒfsƂꂽDāC̍yfDNAE`yfłƗĂD܂CDNAK[[DNAzXt@^[[ȂǉC@\ɂyfĈƂ̒iKɂDNAE`ɕKvł邱Ƃ<a href="#R21"><sup>21,22)</sup></a>CADNAE`͉C@\̕q@\Ɨގ̌oHɂsĂ邱ƂĂi<a href="#F3">}3</a>jD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@AɂDNAE`̋@\</strong>
DNA`ƂȂĔ}ꂽԂɂ`qCDNAE`ƂȂē]ʂ܂ł̉ߒɂ́C܂܂䂪DDMEROS1ȂDNAE`yf̌؂ɁCC@\DNAE`̉ߒł͕K{ł邱Ƃ킩ĂĂD܂CN}`̋@\ϊKvłƍlĂD
<sup>m</sup>CF5-`VgVD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Kinoshita-2.e001-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2013/01/Kinoshita-2.e001-Fig.3.png&amp;caption=fig3-caption-text]


@DNAE`̉ߒ́Ĉ悤ȉC@\ɂ5-`VgV̏̂قɂCDNAE`z̔F⌈CN}`\N}`@\̕ωC邢́CqXgC̕ωƂȂƂ\z<a href="#R19"><sup>19)</sup></a>Dŋ߂̌ɂC̕q@\̈[悤₭݂͂߂ĂĂ<a href="#R23"><sup>23,24)</sup></a>DM҂́Cɏqׂݐ̃Cvg`qł<em>FWA</em>`q̔ł<em>FWA-GFP</em>`q𗘗pāCQmCveBOɈُ̂ψّ̂̑IsĂD<em>FWA</em>`q́C5f̗̈SINEggX|]̑}ɗRƍl锽z񂪑݂CꂪCveBÕVẌł邱ƂĂ<a href="#R25"><sup>25)</sup></a>D̔źCʏCxDNA`Ă`q͗}Ă邪CזEɂDMEɂDNAE`ƈ`q͗U<a href="#R9"><sup>9)</sup></a>Dψّ̂̑IɗpRXgNǵC<em>FWA</em>`q̃QmCveBO̐ɕKvȃVẌ܂łD
@npāCHMGhC<em>SSRP1</em>i<em>structure specific recognition protein 1</em>j`q݂<a href="#R23"><sup>23)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/3658" target="_blank">V_r[</a> łfځjD<em>SSRP1</em>`qFACTifacilitate to chromatin transcription/transactionjqXgVŷ̍\^pNR[hĂ<a href="#R26"><sup>26)</sup></a>Cyꂩqg܂ōLۑĂDSSRP1SPT16ƃweʑ̂`C]ʂ̊JnC]ʐLCDNACDNACȂǁCN}`̋@\ϊKvȐ̋ǖʂɓoꂷqXgVył邱ƂmĂ<a href="#R26"><sup>26)</sup></a>D<em>ssrp1</em>ψّ̂́C<em>FWA-GFP</em>`qłȂƂɂ킦C󐸂ĂȂɂ炸̐L⒆זE̊j􂪂݂ꂽD̂悤ȕ\^͎Iiautonomous endosperm developmentjƂ΂Cق̃Cvg`qł<em>MEA</em>`q̕ψّ̂Ȃǂɂ݂D̂߁C<em>FWA-GFP</em>`q̔wWɑIψّ̂ł͂C<em>SSRP1</em>`q͂ق̃Cvg`q̔ɂe邱ƂlꂽDۂɁC܂܂ȃCvg`q̔𒲂ׂʁC<em>ssrp1</em>ψّ̂ł͑̃Cvg`q̔ɉê݂邱Ƃ킩DɁC<em>FWA</em>`qDNA`̈CȂ킿CQmCveBÕVẌɂDNAE`ɂe邱Ƃ킩<a href="#R23"><sup>23)</sup></a>D
@DNAE`̓́Cǂłǂ̈`qǂ̂悤DNAE`邩ƂɐwIɂ܂邱ƂނƂɂDѐAāCQmChDNAE`̋NזEgD͌ĂDƂ΁CMł͐Bn󐸌̏ȂǌꂽזEɂĔ\IDNAE`ND̂Ƃ͐AɂĂlłCזEgD̂Ȃ̂1̍זEɂȂDāCwIȉ͂ɂ肱̎ɂ܂邽߂ɂ́CGsQm͂ɂ͊x̌IȌƁCזĚIȒP@̊mKvłDŁCh{gDɂDNAE`ɂ͂炭ROS1ɊւĂCǂłǂ̈`qDNAE`Ă邩Ƃɓ̂͂ނD̂Ƃ́Cǂłǂ̈`qƂ₢ɓCȂ킿C󐸑OɁCזEɂāC<em>FWA</em>`qCDNAE`邱Ƃ̖炩<em>FWA-GFP</em>`qpnɂĈ`wIȉ͂sƂł͌ʓIł邱ƂӖĂDŕM҂́Cێ^DNA`yfMET1̕ψّ<em>met1</em>DNAE`yfDME̕ψّ<em>dme</em>Ƃ̓dweڍ̂쐻C<em>FWA-GFP</em>`q̊ɂe͂ĎʁCזEɂ<em>dme</em>ψّ̂<em>FWA-GFP</em>`qłȂƂ\^C<em>met1</em>ψّ̂͊Sɗ}邱ƂꂽDāC<em>dme</em>ψقɂDNAE`̂łȂȂזEłC炩<em>met1</em>ψقɂDNA`̃xቺĂΈ`q͂ЂN邱ƂꂽDCFACTqXgVy̍\^pNR[h<em>SSRP1</em>`q̏ꍇɂ́C<em>met1</em>ψّ̂<em>ssrp1</em>ψّ̂Ƃ̓dweڍ̂ł́CזEɂ<em>met1</em>ψقɂ<em>ssrp1</em>ψق̗}ʂ͔ɎキCقǂ<em>met1</em>ψّ̂<em>dme</em>ψّ̂Ƃ̓dփeڍ̂̌ʂƂ͖炩ɈقȂĂD̂ƂCDNA`̂قCN}`@\<em>FWA</em>`q̓]ʂɑjQIɂ͂炢Ăƍl邱ƂłCق̐ɂĖ炩ɂȂĂ<em>SSRP1</em>`q̋@\<a href="#R26"><sup>26)</sup></a> Ƃ悭vD܂CזEɂĊj͂߂ƁCɂƂȂ<em>FWA-GFP</em>`q̔͏XɋȂĂD̂ƂCDNA`ꂽԂŕԂƁCȂN}`N}`ւƒuĂƂƈvĂ<a href="#R23"><sup>23)</sup></a>Dȏ̒mCf܂Ƃ߂i<a href="#F4">}4</a>jD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@SSRP1DEMTERɂDNAE`ƈ`q̔Ũf</strong>
`wIȉ͂CDNA̒E`ɂDEMETER܂߂C@\FACTqXgVŷ̍\^pNłSSRP1KvƍlD<em>ssrp1</em>ψّ̂ł́CCvg`qł<em>FWA</em>`qDNAE`UȂ߁CȂƂDMETER܂މC@\݂̂łDNAE`͐isȂDSSRP1ɂN}`@\KvƍlĂD
<sup>m</sup>CF5-`VgVD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Kinoshita-2.e001-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2013/01/Kinoshita-2.e001-Fig.4.png&amp;caption=fig4-caption-text]


<h2>3DDNAE`yf̕ψّ̂𗘗pQmChDNA`</h2>
@זEł̋@\DNAE`yfDMEɂāCVCkiYi<em>dme</em>ψّ̂敪ɂQmChDNA`͂ȂꂽDẤCgERVޗDNA`󐫍yfpĂق̑gDƂDNA`r͂CɂĂ͕eɗRQmDNA`͒ቺ邱ƂĂ<a href="#R27"><sup>27)</sup></a>C̏ڍׂ͖炩ł͂ȂDVbgKoCTt@CgV[NGX͂C쐶^̃VCkiYi敪łׂ͂ẴJeS[DNA`̃x敪ႢƂꂽ<a href="#R4"><sup>4)</sup></a>D܂Cڂׂ_́C敪ɂCpHpHz̃`̃x͒n㕔̉h{gD荂ƂłD̑̓gX|]lẑ߁CזEɂDNAE`̌ʁCgX|]̓]ʂЂN24΂̒ᕪqRNA~ςCꂪזE邢ֈڍsăgX|]̗}CƂ񏥂Ă<a href="#R2"><sup>2,4)</sup></a>DŐV̌ł́CDME̕WIƂĂQm̈̏ڍׂ݂ĂĂ<a href="#R5"><sup>5)</sup></a>DDMEATb`500 bpȉ̏ȃgX|]WIƂĂD܂C̓weN}`̈ł͂ȂCkNI\[̏Ȃ[N}`̈ɋǍ݂Ă邱ƂꂽD
@DNAE`yf̕ψّ̂ƂāCh{gDɂ@\̌<em>ROS1</em>`qC<em>DML2</em>`qC<em>DML3</em>`qɑ΂Odψّ̂pQmChDNA`͂ȂĂ<a href="#R4"><sup>4,5,28)</sup></a>D킦āC<em>ROS1</em>`q̕ψّ̂̉͂C̃R[hDNAE`yf͉h{gDɂĉߏɘiLQ5-`VgV菜C`qۏ؂͂炫ĂƗĂ<a href="#R16"><sup>16)</sup></a>Ďʂl킹ƁCADNA`̏_Ci~bNɐ䂳Ă邱Ƃ킩D

<h2>4DYẑɂGsWFleBbNȐ</h2>
@ÃGsWFleBbNȕψق͌Ɉ肵ē`BႪ<a href="#R29"><sup>29)</sup></a>DDNA`̏񂪕ωGsWFleBbNψّ̂́CBߒɂăvO~ONƉ肷ƁCꂽDNA`̏Ƃɖ߂邽ߌɓ`BȂƂ\zD̂߁CA̐BߒɂDNA`̏̃vO~ÓCMƂ͑傫قȂ邱Ƃ\zĂD܂CɏqׂזEɂDNAE`C͖ڂƑމgDȂ̂Ŏɂ͒ڂ͉eȂD킦āC󐸂ɂ鐸j`鐶Bn◑זEւ̐BnɂāCʂȑgD邢͍זEɑ΂͂̂ނ䂦mȃvO~OɊւ͖RDȂCߋɂ́C^oR̉ԕ5-`VgV̍R̂ɂFʂ̕񍐂݂<a href="#R30"><sup>30)</sup></a>Dj̑OזEłYזEɂDNA`̒ቺĂCvO~Ỏ\ĂCR̂ĝߐmȒʐɖR܂lĂ͂ȂD
@2009NɓƁCVCkiYiɂăQmChDNAჁ`UN}`fO^pNDDM1idecreased in DNA methylationj̕ψّ̂pāCǎꂽDNA`̏񂪕ÄƂłȂ̈Ƃ݂邱Ƃ炩ɂꂽ<a href="#R31"><sup>31)</sup></a>D쐶^DNA`̒ቺ<em>ddm1</em>ψّ̂ƂzƁC<em>ddm1</em>ψقɗRQm̈ɂӂDNA`݂悤ɂȂD܂ĈƂRdDMoH̕ψّ̂ł͊ώ@Ȃ߁CᕪqRNA@\ł邱Ƃꂽ<a href="#R31"><sup>31)</sup></a>DǂłƂ͎ĉ́CᕪqRNADNA`̕⏞p̂邱Ƃ炩ɂȂD܂CYźiԕjɂĉh{זE̊jƐזE̊jƂł͂j̑傫قȂ邱ƂCZkẍႢlĂDVCkiYił́Ch{זE̊jɂDDM1͒~ςȂƁCZgAɓٓIȃqXgH3̃oAg͋Ǎ݂ȂƁCԕƐזE̊j21΂̒ᕪqRNA~ς邱ƁCȂǂŕ񍐂ꂽ<a href="#R32"><sup>32,33)</sup></a>D̂ƂCh{זEł̓QmChDNAჁ`̋N邱ƁCɊώ@21΂̒ᕪqRNAɂ萸זEɂgX|]}邱ƁCfƂĒ񏥂ꂽ<a href="#R32"><sup>32)</sup></a>D
@2012NɓC̃fx΂łȂCɉIȔ񍐂_\ꂽ<a href="#R34"><sup>34)</sup></a>Dԕɂĉh{זE̊jƐזE̊jCɂ́C҂̑OזEł鏬EqזE̊jZ\[^[ɂ蕪CQmChDNA`͂ȂтɒᕪqRNẢ͂sꂽDDNA`͂ł́CVbgKoCTt@CgV[NGXɂf[^ƂɁCDNA`̒xɓvIɗLӍ̂̈iDMRFdifferentially methylated regionj肵ĂĎʁCCpGzɊւẮC̍זẼQm̂łDMR͖mɓ肳邪C肳ꂽDMR͔rIȂƂ킩DȂ킿CM̐BnłCpGz̃`QmChɒቺ邱ƂƂ͌ۂقɂĂD܂CCpHpGzɂ͂̍זEɂČDMR͊ώ@ĂȂDŁCCpHpHzɊւĂ͏EqזE̒iKłłɂDNA`̏񂪌IɎĂ邱Ƃ炩ɂȂD̂Ƃ́C<em>de novo</em>^DNA`yfDRM2̒~ςEqזEɂ݂ȂƂxꂽDCh{זEł͂ق̍זEƔrCpHpHz̃`ӂэȂĂĈƂDRM2̋Ǎ݃p^[ƂvĂ߁CVKDNA`̋NĂ邱Ƃ\zꂽDȂ킿CYźiԕj́CזẼ^CvƁC܂CDNA`̃JeS[ƂɈقȂ鐧̋NĂ邱Ƃ킩D

<h2>5DYẑɂCvg`q̐</h2>
@āC̎́CYẑ̌`ߒɂăCvg`q͂ǂ̂悤Ȑ邩łDh{זECpGźCDNAE`x͌肳̂́CזEƂ͖mȍD܂C̑DNAE`yf̕WIzƃI[o[bvĂ邱Ƃ炩ɂȂ<a href="#R34"><sup>34)</sup></a>D܂łɁCDNAE`yf̉ԕɂ@\͖mɂ͕񍐂ĂȂCŋ߂ɂȂC<em>dme</em>ψّ̂ł͉ԕ̔藦ቺƂ񍐂Ȃꂽ<a href="#R35"><sup>35)</sup></a>D̕\^Ƃ̈ʊ֌W͖炩ɂȂĂȂCh{זEƐזEƂDNA`rƁCCvg`qł<em>FWA</em>`q̃VẌC܂CCvg`qł<em>MEA</em>`q5f̗̈3f̗̈CpGz̃`h{זEɂĒቺĂ邱Ƃ炩ɂȂĂ<a href="#R35"><sup>35)</sup></a>DeɗRΗ`qɓٓIɔ<em>FWA</em>`q<em>MEA</em>`q̊́Cẑ̒זEɔDNAE`yfR[h<em>DME</em>`qɈˑĂDŁCDNAE`yfȇł͂炢Ă邱Ƃ́CȌۂłDȂ炱C``BȂh{זEɂDNAE`ł邱ƂɒӂKv邾낤DᕪqRNA̒~ς͂f[^ł́CזEɂĕeɗRΗ`qɓٓIɔCvg`qDMRɂ킦āCeɗRΗ`qɓٓIɔCvg`qDMRɈvC24̒ᕪqRNA̒~ς݂<a href="#R34"><sup>34)</sup></a>D̒ᕪqRNA̗R͉h{זEłƍlĂD܂CזEɂCpGz񂠂邢CpHpHzɑ΂DMRɈvᕪqRNÁCqƔrāC21̒ᕪqRNA葽oĂD21邢24̒ᕪqRNÁCh{זE̊jɂĎYoꐸזE̊jւƈڍsāCꂼgX|]Cvg`q𐧌䂵ĂƍlĂDȂ킿CẑƓlɁC``B鐸זEɂGsQm苭łɕ⋭ĂƍlĂD
@Mł̓Cvg`q̃vO~O͐BnŋNDBnɂẮCO̐DNA`̏āCY̐Bn񂲂Ƃ<em>de novo</em>^`yfɂDNA`܂邱Ƃɂ胊vO~O͊D܂ꂽCvg`qDNA`̏́C󐸗ɂQmChDNAE`ی삳C̍זEւƎ󂯌p邱ƂɂАe̔ێ<a href="#R2"><sup>2)</sup></a>DŁCVCkiYi̕eɗRΗ`qɓٓI<em>FWA</em>`q<em>MEA</em>`qɊւāCeɗRΗ`q̕s<em>de novo</em>^`yfR[h<em>DRM1</em>`q<em>DRM2</em>`qɂ͈ˑȂƂĂ<a href="#R9"><sup>9,36)</sup></a>CDNA`݂̏̃vZX͕KvȂƍlĂD܂CѐAɂQmCveBOł́CDNA`̓GsWFleBbNȏƂċʂėpĂ邪C̐@\͈قȂ邱ƂĂDVCkiYiɂCvg`qDNA`̐́Cɏqׂ悤ɁCsĂ`qȇ̒זEɂDNAE`邱ƂɂsĂD<em>FWA</em>`q́CYẑɂCpGz̃`̈ێ`q̔}ɏdvł邱ƂĂ邽<a href="#R37"><sup>37)</sup></a>CזECpHpHzɂQmChDNA`̏̉e͂ȂƍlCʂƖ͂ȂDŁCŋ߂̃QmCh͂ɂ蓯肳ꂽCvg`qł<em>SDC</em>i<em>Suppressor of drm1 drm2 cmt3</em>j`q́Cv[^[zɑ݂锽z̃VgVRdDMoHɈˑDNA`Ă邱ƂmĂD炭́C̔z<em>SDC</em>`q̃QmCveBOɂVẌƍlDƂɁC<em>SDC</em>`q̗̂̈DNA`́CזECpHpHzɂQmChDNA`̏ی삳Ă邱Ƃꂽ<a href="#R34"><sup>34)</sup></a>DMł̓QmChDNAE`Kvȃ`ی삷@\ĂC֘A@\A݂\D

<h2>6D󐸌̃GsWFleBbNȐ</h2>
@󐸌󔭐̃Xe[WĂ܂܂Ȉ`qDNA`ɂĉ͂f[^C󔭐Xe[WɂCpHpHz̃`̃x̏㏸ώ@Ă<a href="#R38"><sup>38)</sup></a>i<a href="#F5">}5</a>jD܂ĈƂ̓QmChȃf[^ɂĂÂĂ<a href="#R4"><sup>4)</sup></a>DBߒɂGsWFleBbNȐ䂪󐸌̃GsWFleBbNȐɉeƂāCVEWEoG̎Gvہihybrid dysgenesisjD܂Čۂ͂΂ΐA̐BߒɂᕪqRNA̐ƔrĘ_Ă<a href="#R1"><sup>1)</sup></a>DVCkiYi󔭐̉ߒɂCpHpHz̃`RdDMᕪqRNAɂ萧䂳Ă<a href="#R38"><sup>38)</sup></a>D܂CɌƂ߂錻ہCƂ΁C{̂̂̌GɂᕪqRNA֗^ĂCqTCY̐ɂĂ邱ƂĂ<a href="#R39"><sup>39)</sup></a>Dq̓on̉ߒł͕eɗRᕪqRNAɒ~ςĂ<a href="#R40"><sup>40)</sup></a>ĈƂƂ̊֘A[D

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@Yẑ̌`ߒ</strong>
Yẑ́CEqזĚ̂̂CEqזE2̑̍זEւČ`D1ڂ̕ł́Csɂh{זEiԕǍזEƂ΂jƗYזE`D̂̂C2ڂ̓̕VCkiYił͉ԕ̐n̂܂ɋNCYזÊݕ􂵂2̐זE`D̉ߒł́CEqזE̒iKCpHpHz̒Ⴡ`ώ@ĂCh{זEɂȂCpHpHz̃`x͂ӂя㏸DזEłCpHpHz̃`̃x͒ႭC󐸌łCpHpHz̃`x͂ӂя㏸邽߁Ceiԕj̑CpHpHz̃`ɊւĂ̓vO~Ȏ݂ĂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Kinoshita-2.e001-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2013/01/Kinoshita-2.e001-Fig.5.png&amp;caption=fig5-caption-text]


<h2></h2>
@܂ŏqׂĂ悤ɁCV[NGT[pDNA`͂ȂǂƂāCA̗Yẑ̉h{זEƐזEƂ2̍זEɂC3̃JeS[DNA`̐䂪炩ɂȂĂDזEɂCpHpHz̃`̏Ǝ󐸌̃vO~Ő@\CBɑ΂tIȋ@\h{זEɂCpGzDNAE`̋@\CāCזEƂ̒ᕪqRNÂƂ̌ʂ炳Qm̈萫C̉ߒ̐wIȈӋ`ɊւĂC܂܂邱ƂƗ\zĎ̓˔jƂȂ̂́C܂łȂ1זE탌xł̉͂łD̉ۑƂāCɋZpvVKvƍl邪CזEւזEnɂGsWFleBbNȐɂ܂KvD炭́CȂɖ炩ɂȂł낤D
@ŉA̐BߒɂGsWFleBbNȐ@\́CVCkiYî悤ȋψȃQm񂨂уGsQmf𒆐SɌi߂ĂDŁĆCqg܂߈`񂪋ψł͂ȂΏۂɁCWcь̂ɂGsQmɑl݂͂ȂCGsWFleBbNȏ͂ǂ̂悤Ɋ拭ێĂ̂C܂C̑la瀂ƗLBɂǂ̂悤Ȕj]̂C炪Nł̐ỉߒɂǂ̂悤ɉêC̑ΏۂLĂ̂ƎvDƂɐÁCԂ{̊ԂɂǦ`rIeՂłCG틭̋@\ȂǁC̉ߒɂGsWFleBbNȐ@\̉𖾂̉ۑłƍl<a href="#R41"><sup>41)</sup></a>D

<h2> </h2>
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</ol>

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