̐onɂ_oȞ`̎ԓIȐ@\

<strong>͍ mu</strong>
iwی ]ẼC^[tF[XfBVZ^[q_oȊwj
emailF<a href="mailto:kawasaki-labo@umin.ac.jp">͍mu</a>
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̈Zr[, <strong>3</strong>, e010 (2014)@<a href="http://dx.doi.org/10.7875/leading.author.3.e010">DOI: 10.7875/leading.author.3.e010</a>
Hiroshi Kawasaki: <strong>Spatiotemporal regulation of the formation of the somatosensory system.</strong>

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<h2>v </h2>
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<h2>͂߂</h2>
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<h2>1Do_onp̓</h2>
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@2ɁC_ỏY̌ɓKĂ_łD]_on͉YɂOE̓͂ɑ΂@\I邢͍\IɕωDɏqׂ悤ɁCo_onɂĂ͓͂̑삪eՂł邱ƂC_ỏYN₷D
@3ɁCYɂՊĚɓKĂ_łD_ỏY͕KUł݂킯ł͂ȂC{Iɂ́Cô̂CB̏̂ꎞɂ̂݌肵Ă݂邱ƂD̉YIȕω̋N肤鎞͗ՊEi邢́C󐫊jƂ΂DBɂāCՊE̊JnяI𐧌䂷镪q@\̉𖾂͓IɍsĂD̂悤ɁCo_on͔]_oň`@\̌ɂďdvȈʒu߂ĂD

<h2>2D̐on̊{Iȍ\zь`̉ߒ</h2>
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iajqQ̐GõVOíCO_ojCVPMjāC]玿1̐oւƓ`BD
ibj̐on̊on}DqQ̕zɑΉon}̐o_onɂđ݂DԐFŎqQɑΉ\CԐFŎD
icj1̐oɂo̍\D]玿̒fʐ}Do͑]玿̑4w̃j[̒M̋ԕzłD̂ȂɃVOi̓͌łVPMjɗR鎋玿zD
idj1{̃qQ̃VOíC1̃oւƓ`BD
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@ނ̑̐onɂ̓qQ̕z𔽉f̐on}݂̑Ă邱ƂIłDqQɑΉgD̍\́CO_ojł̓obgibarrelettejCVPMjł̓oChibarreloidjC1̐oł̓oibarreljƂ΂Ăi<a href="#F1">}1b</a>jDƂɁCo͑]玿̑4wɑ݂Cj[̒M̋ԕzłi<a href="#F1">}1c</a>jD1̃o͊{Iɂ1{̃qQ̓͂ƍlĂĈ܂̃qQ̕zɑΉāC1̐oɃozĂi<a href="#F1">}1d</a>jDo̓ɂ̓VOi̓͌łVPMj̎玿zi<a href="#F1">}1c</a>jDo̓j[ߏoNeuNɂƉuFɂ邱ƂłDɁC玿FVGluT2ɂƉuFZgjÂɂƉuFCɂ́CVgNILV_[[FłłD̂悤ɁCȕւȕ@ɂ̍\ł邱Ƃo̓łČɗp闝RłD
@]玿̑4wɂoƃô̗̈̓Zv^Ƃ΂CoƂ͈قȂ閖̃VOi`BƍlĂDo͎VPMj̓͂邪CZv^͎łPoMj̓͂D܂CoƃZv^͂̐onɑ邪قȂ鎿̃VOi`BĂDo̓qQɂGo`B̂ɑ΂āCZv^̃j[͐Gohւ̔アDނCZv^̃j[̓Y~JȃqQ̓ɔ邱ƂCZv^̓qQ̐ϋɓIȓj^[ĂƍlĂD
@̂悤ɁC]玿̑4w̃j[ւGo̓͌oHɂĂ͏ڍׂɌĂCۂɏ񏈗s]玿̓̐_oHɂĂ͂܂sȓ_cĂDŕM҂́Cq{dCE@ɂ]玿̑2wё3w̃j[ɂđIIGFP𔭌̑s͂ĎʁC]玿̑4wɂăZv^ɑ΂WIɓ˂Ă邱ƂoC̓˂̃p^[olbgibarrel netjƖ<a href="#R3"><sup>3,4)</sup></a>i<a href="#F2">}2</a>jD낢ƂɁCmCherryƃVivgtBV-GFPZ^pN]玿̑2wё3w̃j[ɋƂColbgɃVivX݂̑邱ƂColbg͋@\Iɏdvł\ꂽDƁColbg̓oƃZv^̃VOiт_oHȂ̂ȂD_ł́CoolbgȂǂ̍\z̋@\IȈӋ`͖炩ɂȂĂ炸C̉͂҂D

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@olbg̍\</strong>
iaj]玿1̐o̊fʁD2wё3w̃j[́C4wł̓Zv^ɗDIɓ˂ĂD
ibj]玿1̐o̐ڐ̒fʁD2wё3w̃j[̎́C4wł̓Zv^ɗDIɓ˂ĂD
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@o܂߂̐oň`̉ߒ킵ׂĂDǒ`̏ɂ́CO_ojCVPMjC1̐ôɂĂC˂Ă鎲̓qQƂ̕ɏdȂ荇ĂC̃qQ̃VOi荇ē˂Ăi<a href="#F3">}3</a>jD̏Ԃ珙Xɖ̑11̃qQւ̕i݁CɁCobgCoChCo`D̂悤ɁCǒ`̏ɂ1{̎玿̃qQɑΉoɓ˂Ă邪C`iނ1{̃qQɑΉoɓ˂肳悤ɂȂD܂C]玿̑4w̃j[̔zuɂĂCǒ`̏ɂ͈lɕzĂ邪C`iނƃǒ`ɍĔzuD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@B̉ߒɂǒ`уőԓIȃp^[̌`ɕKvȃ^pN</strong>
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@]玿̑4w̌X̃j[ɂĎˋŇ`Ԃώ@ƁCǒ`̏ɂ͂ɕˏɎˋNL΂Ă邪Cǒ`iނɂĎˋN̓o̒S̕Ɍ肵đ݂悤ɂȂDŋ߁C2qp邱ƂɂC̎ˋN̍č\z𐶌܂Ȃ}EX̔]ɂĊώ@邱Ƃ\ɂȂ<a href="#R5"><sup>5)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/8623" target="_blank">V_r[</a> łfځjDč\zɍۂĂ͎ˋNLяk݂Ȃo̒SɂނXɐL΂Ă_Ci~bNȕωώ@ꂽDNMDA^O^~_êƁCˋÑo̒Sւ̎w͎ꃉ_ɕzߒώ@ꂽ<a href="#R5"><sup>5)</sup></a>D

<h2>3D̐o_on̋ԓIȌ`̐@\</h2>
@܂ŏqׂ悤ɁC̐oño͌`̉ߒڍׂɋLqĂC܂Cq`wIȉ̗͂eՂȃ}EXpČł邱ƂC_oȞ`č\z̃fnƂđpĂ<a href="#R2"><sup>2,6-8)</sup></a>i<a href="#F3">}3</a>jDNMDA^O^~_ễmbNAEg}EXł́C]ɂobǧ`jQĂ邱Ƃ񍐂ꂽDɁC]玿̋j[Ɍ肵NMDA^O^~_êNR1TujbgCxNR1mbNAEg}EXł́CobgƃoCh͐ł邪oɈُ킪݂ꂽ<a href="#R9"><sup>9)</sup></a>D]玿̑4wɂăo̍\CΉ鎋玿̌`sSłDɁCȃ}EXł̓o̒S̕ɂނĂ]玿̑4w̃j[̎ˋNCo̒Sւ̎wĂD܂Cӌ^O^~_emGluR5̃mbNAEg}EXɂĂǒ`Ɉُ킪݂ꂽ<a href="#R10"><sup>10)</sup></a>Ďʂ́C]玿ɂO^~_ɂ_o`Bǒ`ɕK{ł邱ƂĂDO^~_ểɈʒu^pNƂāCNeuroD2уzXzp[[C1lĂDNeuroD2Ca<sup>2+</sup>ɂU]ʈqłCNeuroD2̃mbNAEg}EX̓ǒ`Ɉُ<a href="#R11"><sup>11)</sup></a>DNMDA^O^~_ê痬Ca<sup>2+</sup>NeuroD2ăǒ`𐧌䂵Ă\D܂CzXzp[[C1̃mbNAEg}EXoɈُ<a href="#R10"><sup>10)</sup></a>DzXzp[[C1mGluR5̉ł͂炢Ă\DC炪]玿̑4w̃j[ɂĂ͂炢Ă邩ȂǁCS̑𖾊mɂ邽߂ɂ͂ɏڍׂȉ͂Kvł낤D
@܂C_o`BłZgjǒ`Ɋ֗^Ă邱ƂmĂi<a href="#F3">}3</a>jDZgjyfł郂mA~_yfÃmbNAEg}EXɂẮC]玿̑4w̃j[̕zёΉ鎋玿̂ɂĂCǒ`ꂽ<a href="#R12"><sup>12)</sup></a>Ďʂ́CZgj̔Zx㏸ƃǒ`jQ邱ƂӖĂDɁCZgjזEɎ荞ރZgjẪmbNAEg}EXɂĂǒ`jQĂƂCזEÕZgjZx̏㏸ǒ`ُ̈ɂȂƍl<a href="#R13"><sup>13)</sup></a>DɁC̃mbNAEg}EXƃZgj1BễmbNAEg}EXƂ|킹邱ƂɂCǒ`ُ̈͌y邱Ƃꂽ<a href="#R14"><sup>14)</sup></a>Ďʂ́CזEÕZgjZx̏㏸́CȂƂIɂ̓Zgj1BêoĂ邱ƂĂDɁCAfj_VN[[1Ɉُ̂}EXɂĂ̓ǒ邱ƂmĂDזEÕZgjZx̏㏸ɂZgj1BêhC̉ɂăAfj_VN[[1}ăǒ`ُ̈ɂȂƐĂD
@܂C]玿̑4w̃j[ɂˋŇ`ԓIȔB̋@\ɂĂ͂ĂDɃo̒SɂĔ݂̂Btbd3̔shRNAɂmbN_EƁCł̓o̒S̕ɑIIɂނ͂̎ˋNCZv^ɂ݂ˏɕz邱Ƃ킩<a href="#R15"><sup>15)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/7992" target="_blank">V_r[</a> łfځjDɁCBtbd3oɋ_oɋ`邽ߕЊՕƁCˋŇ`Ԃɕω̋N邱Ƃ킩Ďʂ́CBtbd3]玿̑4w̃j[ɂˋN̍č\zɏdvł邱ƂӖĂ<a href="#R15"><sup>15)</sup></a>D܂CBtbd3͖쐶^}EXł͊jɏWςĂ邪CNMDA^O^~_ễmbNAEg}EXł͍זEɋǍ݂ĂĎʂ́CO^~_ɂ_o`BƂȂCBtbd3jւƈڍs邱ƂɂˋŇ`Ԃ̍č\zЂN\Ă<a href="#R15"><sup>15)</sup></a>D
@ŋ߁CM҂́CɏqׂolbgpāC]玿̋Ǐɂ_oȞ`@\ɂČ<a href="#R16"><sup>16)</sup></a>Dq{dCE@pđ]玿̑2wё3w̃j[GFP𔭌邱Ƃɂolbgł邱ƂCGFPƂƂɁColbǧ`𐧌䂷\̂^pNĎʁCDs\^Jhw𓱓ۂɃolbǧ`jQ邱ƂoDɁCDs\^Jhw𔭌ƃolbǧ`͑jQ邪Colbg`ꂽƂɗDs\^Jhw𔭌Ăolbg͉ȂƂ킩D̂Ƃ́CזEڒqłJhwolbg̈ێł͂Ȃ`ɏdvł邱ƂĂ<a href="#R16"><sup>16)</sup></a>DJhw͐_oH̑IIȌ`ɏdvł͂ȂƍlCۂɁC]Cnɂ_oȞ`ɏdvł邱Ƃ񍐂ĂDȂC]@\̒ł]玿ɂJhw̖ɂĂ͕sȓ_Ď̌ʂ́CJhw͑]玿̋Ǐɂ_oȞ`ɂdvł邱ƂĂ<a href="#R16"><sup>16)</sup></a>D

<h2>4D̐o_on̎ԓIȌ`̐@\̗тق̐_onւ̔gy</h2>
@]_oň`@\𗝉邽߂ɂ2̎_dvł낤D1́CԓIȃp^[̌`@\̗łC܂ŏqׂĂ悤ɁC̐IȌʂĂD2́CԓIȐ@\̗łDȂ킿Č`Cxg͔邢͔B̉ߒɂẴ^C~OŋN邱ƂK{ł邱ƂC̃^C~OK肷鎞ԓIȐ@\̗dvȂ̂łĎ`Cxg{Ƃ͂܂قȂ鎞ɋNƁC`ُ̈ɂȂƗ\zD̂悤ɁCԓIȐ@\͏dvłɂ炸CԓIȃp^[̌`@\ɔוsȓ_D
@M҂́C1̐oɂǒ`̎ԓIȐ@\ɂĉ͂D}EXَ̑ee琶܂ĂɃǒ`͐is邱ƂCoꎩ̂ǒ`JñXCb`łƂ̉Ă<a href="#R17"><sup>17)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/7799" target="_blank">V_r[</a> łfځjD̉؂邽߁C}EXɐlדIɑYUCǒ`ɂČDoY̎𐳊mɋL^邽߁C؂ԊOrfIR[_[pċL^ČʁCYŐ܂ꂽ}EXł͐Ỹ}EXɔrăoLӂɑɌ`邱Ƃoi<a href="#F4">}4a</a>jD̃ȏ`́C`̑x̂ł͂ȂC`̎܂邱ƂłD̂ƂCoǒ`̊JnK肵Ă邱ƁCсCoǒ`Jn𐧌䂵Ă邱Ƃꂽ<a href="#R17"><sup>17)</sup></a>i<a href="#F4">}4b</a>jD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@ǒ`ɂ鎞ԓIȐ@\</strong>
iaj}EXɐlדIɑYUƁCoɌ`D̎Ԃ̌o߂͎󐸂̂̂̓ł邱ƂɒӁD
ibjoɂ_oȞ`̖͎̐}DoƂȂCזEÕZgjZxቺČʁCǒ`C邢́CɓٓIȎ˂̌`ND
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@ɁCoƃǒ`ƂȂq@\ɂĉ͂DőԓIȃp^[̌`ɂ`q̂ꂩC͎ԓIȗiKłỏɈʒûł͂ȂƍlD_o`BłZgj̍זEOZxُɍmA~_yfAmbNAEg}EXł̓ǒ`jQ邱Ƃ񍐂ĂCȔBɂZgj̐IȖ͕słDŁCZgjỏɈʒuǒ`̊Jn𐧌䂵Ă̂ł͂Ȃƍli<a href="#F4">}4</a>jDۂɁC]ҐtɂăZgj̔Zx𑪒肵ƂCô̂ɃZgjZx͒ቺ邱ƁCсCYɂZgjZx̒ቺ鎞͑܂邱ƂoĎʂ́CoZgj̔Zxቺ𐧌䂵Ă邱ƂĂ<a href="#R17"><sup>17)</sup></a>DÂāCZgj̔Zxቺǒ`Jn𐧌䂵Ă̂ǂD܂CZgj̔Zxቺ̏\ɂČ邽߁CZgj̍jQăZgj̔Zxቺ𑁊ɐƂCǒ`̎܂邱ƂoDtɁCZgj̔Zxቺ̕KvɂČ邽߁CZgj̕jQƂCǒ`ɑ΂鑁Y̌ʂjQꂽĎʂ́CZgj̔Zxቺoɂǒ`JnɕKv\ł邱ƂĂ<a href="#R17"><sup>17)</sup></a>i<a href="#F4">}4</a>jD
@o̐onɂ_oȞ`𐧌䂵Ă邱Ƃ킩C@\IȔBoɂ萧䂳Ă̂ǂDŁCô̂ɔBMsɒڂ<a href="#R18"><sup>18)</sup></a>D}EX̐Ve͏o̒ɂ͓݂ċzM͂߂܂łɎԂ邪CXɏBZԂŚMł悤ɂȂD̚M܂ł̎Ԃ̒Zkoɂ萧䂳Ă邩ǂDYŐ܂ꂽ}EXƐYŐ܂ꂽ}EX̚M܂ł̎ԒZkɂČƂCYŐ܂ꂽꍇɂ͎ԒZki邱Ƃo<a href="#R18"><sup>18)</sup></a>D낢ƂɁC^@\̎wWłN蔽˂͑ỶeȂĎʂ́CMs̔Boɂ萧䂳Ă邱ƂĂ<a href="#R18"><sup>18)</sup></a>D
@̐onfƂČoꂽCoZgj̔Zxቺ_oȞ`CƂVȐ@\Cق̐_oȞ`䂷ʓIȐ@\ł邩ǂ<a href="#R17"><sup>17)</sup></a>Dɏqׂ悤ɁC]ҐtɂZgj̔Zx͏ô̂ɒቺC]Ґt͔]̂܂܂ȕʂɂӂĂ邱ƂCZgj̔Zx̕ω͔]̂܂܂ȕʂɉeĂ\ƍlDŁCoƓlɏo̒Ɍ`CmA~_yfAmbNAEg}EXɂĈُɂȂɓٓIȎ˂ɒڂD̂ł́CEႠ邢͍ɗRዅ̖Ԗ_oߍזE̎́C̓ːłOĜɂĈقȂ̈ɕē˂ĂCɓٓIȎ˂Ƃ΂DɓٓIȎ˂͏o̒ɂ͂܂Ă炸CɗRԖ_oߍזE̎͊OĜɂč݂Ă邪Co10قǂŉEႨэɗRԖ_oߍזE͕̎ɓٓIȎ˂D̊ɓٓIȎ˂̌`͑Yɂ董i邱ƁCɁCZgj̔Zxቺɂ董i邱Ƃoꂽ<a href="#R17"><sup>17)</sup></a>Ďʂ́CoZgj̔Zxቺɂ鐧@\Conɂ_oȞ`䂵Ă邱ƂӖĂ<a href="#R17"><sup>17)</sup></a>i<a href="#F4">}4</a>jD̐@\Cɑ̔]̈ɂ_oȞ`𐧌䂵Ă̂[D

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@o_onpɂāC_ỏY邢͗ՊȄI̐̋@\ڂ߂ĂD̐onł́CqQQ邱Ƃɂ1̐õoɉYIȕωЂNƂłC̓qQ̏QɂỏYƂ΂DȂ킿CQqQɑ΂okCאڂog傷D̃qQ̏QɂỏY̋@\ɂ͂܂sȓ_CO^~_A1̃mbNAEg}EXɂẮCǒ`͐ł邪qQ̏QɂỏYɈُ݂̂邱Ƃ񍐂ꂽ<a href="#R19"><sup>19)</sup></a>D܂CO^~_-AXpM_ẪmbNAEg}EXłqQ̏QɂỏYɈُ킪݂ꂽ<a href="#R19"><sup>19)</sup></a>Ďʂ́CO^~_ÂqQ̏QɂỏY𘴐iĂ邱ƂĂD
@܂CqQ̏QɂỏY͏o̒̈ꎞɂĂ݂C̗ՊEƗUȂD̂悤ɁCՊEIƃqQ̏QɂỏY@\ڂĂCoɂ_o`BłZgjO^~_̊֗^ꂽDZgjyfł郂mA~_yfȂjQ܃NM邢̓mA~_yfAmbNAEg}EXp͂ł́CՊȄIɉe݂͂Ȃ<a href="#R20"><sup>20)</sup></a>D܂C]玿̋j[Ɍ肵NMDA^O^~_êNR1TujbgCxNR1mbNAEg}EXłCՊE͐ɏIĂ<a href="#R21"><sup>21)</sup></a>Ďʂ́CqQ̏QɂỏYɂՊȄI̓ZgjO^~_ɂ萧䂳ĂȂƂĂD
@oł͎ĐjQ^pNłNogoANogoBC܂C̎êՊȄI𐧌䂵Ă邱Ƃ񍐂ꂽ<a href="#R22"><sup>22)</sup></a>D܂CĐjQ^pNƂĂقɂMAGOMgpȂǂ̂邱ƂmĂDM҂́C炪ISfhTCgɋʂĔĂ邱Ƃ𗘗pCISfhTCg邱Ƃɂ肱̎ĐjQ^pN̔܂Ƃ߂đjQ<a href="#R23"><sup>23)</sup></a>DISfhTCg̔ɕK{ȓ]ʈqOlig1̃mbNAEg}EX͂CqQ̏QɂỏYɂՊȄI͉ĂȂ<a href="#R23"><sup>23)</sup></a>Ďʂ́CqQ̏QɂỏYɂՊȄIɂ̓ISfhTCg͕svł邱ƂĂ<a href="#R23"><sup>23)</sup></a>D̂悤ɁC̐onɂՊȄI̋@\ɂ͕sȓ_C̉͂҂D

<h2></h2>
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<h2> </h2>
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<h2>Ql}</h2>
<ol>
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</ol>
<ol>
<span class='au'>Erzurumlu, R. S., Guido, W. & Molnar, Z. (eds.)</span>: <span class="ti">Development and Plasticity in Sensory Thalamus and Cortex.</span> <span class='so'>Springer-Verlag, New York (2006)</span>
</ol>
<div class="au-profile">
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<span class="author">͍ muiHiroshi Kawasakij</span>
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