Đ̐@\FZƂĂ̐_oȊw

<strong>叼 </strong>
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emailF<a href="mailto:kkadoma@med.nagoya-u.ac.jp">叼</a>
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̈Zr[, <strong>3</strong>, e005 (2014)@<a href="http://dx.doi.org/10.7875/leading.author.3.e005">DOI: 10.7875/leading.author.3.e005</a>
Kenji Kadomatsu: <strong>Mechanisms of axon regeneration and its inhibition: Glyco-neuroscience as a research of combined disciplines.</strong>

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<h2>v </h2>
@_o̎͑̂ɂĐDC_o̎͂ǑƂقƂǍĐȂDĐ鎲̖[͐~`邪C_ȏɂ͑dystrophic endballƂ΂鎲̖[oDǂ̒ƕsɍč\zƐ~`邪Cdystrophic endballł͂ꂪĂDC͍זEɓݐ̗vɂ̂ł͂ȂCזEÖqɂUD̍זEOq̂ȂłveIOJ͏dvłD|{ɃveIOJ̔Zxz`邱ƂɂC<em>in vitro</em>ɂĂdystrophic endballU邱ƂłDveIOJ̓RA^pNƒȓȂC̓ƂăRhC`_CP^_Cwp_ȂǂmĂDRhC`_уP^_͍זEOɂđjQqƂĂ͂炭C낢ƂɁCwp_͎ɑ݂điqƂĂ͂炭D킦āCRhC`_̓VivX̉Yɂďdvȗ}qł邱Ƃ킩ĂD̂悤ɁCȊwƐ_oȊwƂ̗Zɂ͂߂Ă݂_ő@\䂪炩ɂȂD̃r[ł́CĐ̐@\ɂĐ̂CRhC`_ƃP^_𒆐Sɓ̍p@\ɂ܂D

<h2>͂߂</h2>
@̂̍󍂕qioCI|}[jƂāCj_C^pNCDj_C^pNƂȂœ3̐Ƃ΂䂦łDȂC̍쓮邢͋@\̗͌IłDƂČ̗l͈lł͂ȂC򂪂C܂C̃Xebv̌ɕ̍yfĂi<a href="#F1">}1</a>jD̂Ƃ́CЂƂ̍𐶍̂Ɋ̓ƗZghO}̐ԓIɂĂ邱ƂӖĈ߁C̉e₷D܂C̐̓ZghO}̏ꂽƂŐ䂳Ăi<a href="#F1">}1</a>jD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@̐ƃZghO}</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/05/Kadomatsu-3.e005-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2014/05/Kadomatsu-3.e005-Fig.1.png&amp;caption=fig1-caption-text]

@C^pN⎉͑ɂ킽D͂^pN⎉̈Ⴂɂ炸ʂ̋@\邪CtɁC^pN⎉ɈˑꍇD܂Cyf̃mbNAEgz肵ĂC^pN⎉IԂƂ͂łȂC܂CIɕʂ̍\̐U邱ƂD̂ƂC̐̓ZghO}班ꂽƂŐ䂳Ă邱ƂӖD
@ȊwłꂽZpђḿC傤ǌ݂̕qwł悤ɁCɓIɂ͂鐶ȊwɐׂłD͏dvł͂Cق̐̕Ȋw҂ɂƂ蓜قǈɂ~̍̂͂Ȃł낤D̑sȃS[߂ɂ́C̉͂̂߂̋ZpvVȂǁC܂܂ȉۑ̉KvłDCЂƂ蓜Ȋŵ΂肾ł͕͂s\łCȊŵق̕Ƃ̋ƂdvłDȂ킿Cɂ鐶Ȋw̐[x̎Ⴊ܂ɂӂƂCȊwѐȊw̐^̔W҂łDM҂Ƃ_owɂĂC̎_邱ƂɂC܂ł݂ȂV_o@\̐@\炩ɂȂi<a href="#F2">}2</a>jD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@_ow</strong>
iaj܂ł̐_oȊw̌D
ibjꂩ̐_owD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/05/Kadomatsu-3.e005-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2014/05/Kadomatsu-3.e005-Fig.2.png&amp;caption=fig2-caption-text]

@̃r[ł́C_oȊwƓȊwƂ̗ẐȂłEIɂƂɐił镪̂ЂƂƂāCĐƂ̑jQ̋@\Ƃ肠D܂C݂܂łɒmĂ鎲Đ̐@\ɂĂ܂Ƃ߁CÂāCł̓̋@\̈Ӌ`эp@\ɌyD

<h2>1D_oƒ_o</h2>
@XyC̐_oUwCajal̓j[̒񏥂ɂm[xww܂܂CقɂX̋ƐтcĂDgǏQ_o2xƍĐȂhDCajal1I܂ɎctłDCajal͑_o̖̎[тȋ`̌`Ԃ悷邱Ƃ𔭌Ddystrophic endballi邢́Cretraction bulbCfrustrated growth conejƂ΂邱̌`Ԃ́C_ȏ̂ЂƂ̏ےIȃ}[J[łi<a href="#F3">}3</a>jD_oł͑ɂăOAזE̊яWςNCOAፍ`DƂɁCAXgOA͑̃^pNYꎲĐ𒼐ڂɑjQDāCOAፍ͕IȏǂƂĂłȂCqIȏǂƂĂĐjQĂƂD܂C_oɂ݂ݐ̎Đ̋@\_oł͏\ɂ͂炩ȂƂC_oɂ鎲ĐނĂЂƂ̗RłD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@_oђ_oɂ鎲Đ</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/05/Kadomatsu-3.e005-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2014/05/Kadomatsu-3.e005-Fig.3.png&amp;caption=fig3-caption-text]

@_oSchwannזEɂ肨Ă邪CSchwannזE͂܂C~jCIV^R[QCփp_veIOJȂǁCזEO}gbNX\镪qYꖌ`i<a href="#F3">}3</a>jĎʁC_o̎̑͊ꖌɂ`ꂽɂD̊ꖌ̓͑̂̂c邽߁CWallerϐɂ͊ꖌKChɂĐmɍĐDƂ̂C~jCIV^R[QCփp_veIOJ͎Đ̑iqł邩łDWallerϐɂƂȂ~G̕YSchwannזE}Nt@[Wɂ肷݂₩ɏ邱ƂCĐ̑jQq̍pӂƂϓ_dvłDāĈ̂C_o̖̎[͐~̌`ԂƂ莲͍ĐDdystrophic endball`čĐȂ_o̎Ƃ͍DΏƂłi<a href="#F3">}3</a>jD
@ȂC_o̎ĐLqƂsproutingi}jƂt𕹋L邱ƂD́C_o̎̂܂܍Đ邱Ƃ͂قƂǂȂCނC}ɂVȃlbg[N`邱ƂقƂǂł邱ƁCāCĐƕ}ƂɂƂɂDȂC}̖[dystrophic endball`邱ƂCזE̓ÕVOi͍Đƕ}ƂŕςȂ悤ɎvDāC̃r[ł́C܂Ƃ߂ĎĐƂԁD

<h2>2DĐ̑i@\FזEэזEȎiq</h2>
@㍪_oߐ_o͊o_oł1{̎DC͖̎ƒ2{Ɏ}ꂵĂD}͋ؓ畆ȂǂɒBC}͐ҐɒBDҐȂǂɂ蒆}Ă͍ĐȂC炩ߖ}𑹏Ăiperipheral conditioning lesionCÂQƂjĈ̂ɒ}𑹏ꍇɂ͎Đ͑iD̂Ƃ́CÂQɂĐ̃VOi炩ߊjւƓ`BꂽƂӖC܂C_o̎Đɂēݐ̍Đ\̑iƂ헪藧ƂD
@āCĐ̃VOijɓ`Bɂ́Ĉ̂\bŊjɓ`BCa<sup>2+</sup>gƁCǂɂ^pNtsA̔g2KvłDCa<sup>2+</sup>g̓eghgLVNa<sup>+</sup>`lCNa<sup>+</sup>/Ca<sup>2+</sup>ÁCdʊJ^Ca<sup>2+</sup>`lCCmVg[gX_êƂ̑uɂ`B<a href="#R1"><sup>1)</sup></a>D̔g̓veCLi[[Cʂ̃_CqXgEAZ`yfHDAC5̃_C_HDAC5̊jOւ̈ڍsCqXg̃AZ`̘iCƂA̔ЂNCĐɕKvȃ^pNR[h`q̓]ʂ̑iɊ^<a href="#R2"><sup>2)</sup></a>D^pNtsA̓_Cj[^[^pNƂĎgC̐ὠׂoGeBɕxłDωׂɂ̓_DLKC_JNK3C_STAT3C_ERKȂǂ܂܂<a href="#R1"><sup>1)</sup></a>DSTAT3ERK͋ǏɂĖ|󂳂CǏɂĖ|󂳂ꂽimportinvimentinƂꂼꌋCimportinƂƂɐωׂƂėAĂD
@Đ̑iɊ^זẼVOi`BnƂẮCȂƂ3DȂ킿CJAK-STATnCRAF-MEKnCPI3K-mTORnłi<a href="#F4">}4</a>jD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@Đ̑iqёjQqƂ̋@\</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/05/Kadomatsu-3.e005-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2014/05/Kadomatsu-3.e005-Fig.4.png&amp;caption=fig4-caption-text]

@gp130͂܂܂ȃKhɑ΂ê̍̕\^pNƂȂC̉ɂJAK-STATn@\DƂ΁Cgp130̃KĥЂƂłLIF}EX͖ÂQɔȂ<a href="#R3"><sup>3)</sup></a>DSOCS3JAK-STATnɂ}^pNČɂ莋_ȏɂ鎲Đi<a href="#R4"><sup>4)</sup></a>Dgp130̕ʂ̃KhłCNTF̔͐_ȏɂUCCNTFSOCS3̓dɂ莲Đ͑Iɑi邪Cgp130SOCS3̓dł͂̌ʂ͂܂<a href="#R4"><sup>4)</sup></a>i<a href="#F4">}4</a>jD
@ÓTIȃVOi`BnłRAF-MEKnɂẮC܂ŎĐɂđoĂCŋ߂̃GKgȎɂ肢݂̌DȂ킿C㍪_oߍזEю_oɂēٓIB-RAF𔭌ƎĐiČʂMEK1邢MEK2̌ɂ<a href="#R5"><sup>5)</sup></a>i<a href="#F4">}4</a>jDRAF-MEKn̉ɂĂǂ̃^pN@\Ă邩ɂĂ͂܂sł邪CRAF-MEKn͔ǂ̈艻ɂďdvHDAC6𐧌䂵ĂCɋ@\Ă\D
@PTENPI3K-mTORnɂ}^pNłD_oɂēٓIPTENƎ_o̎Đi<a href="#R6"><sup>6)</sup></a>i<a href="#F4">}4</a>jDɁCB-RAF̔PTEŇ͎Đɑ΂Iɂ͂炭<a href="#R5"><sup>5)</sup></a>D܂CRAF-MEKnPI3K-mTORn̓NXg[NĂ\D
@3̃VOi`Bnɂ킦CcAMPCATF3CDLK-1̏dvɂĂӂD㍪_oߐ_oɂזEcAMP̃x͐3`4ڂɋ}ɒቺDɌĉāC~G~G֘A^pNɂ㍪_oߐ_o̎̐L͗}D̗}cAMP̃AiOɂ<a href="#R7"><sup>7)</sup></a>i<a href="#F4">}4</a>jDATF3cAMPɈˑ̓]ʈqłDATF3͖ÂQɂ蔭iDATF3𔭌gXWFjbN}EXł͖_ȏɂĎĐiĂ邪CҐ̂悤Ȓ_ȏɂĂ͌ʂȂi<a href="#F4">}4</a>jD̂Ƃ́CזEOɑ݂鎲Đ̑jQqɑ΍Rʂ͂Ȃ̂́CATF3Đ̑iqł邱ƂĂDDLK-1RAFƓMAPKKKɑDɂ<em>daf-2</em>ψق݂͒̂łȂCĐɘiĂDDAF-2̉ɂė}]ʈqDAF-16/FOXÓC<em>daf-2</em>ψّ̂ɂĂ͗}Ȃ߁C̉DLK-1̔㏸DDLK-1Ƃ̉̃VOi͔ǂ̍č\ɏdvł邽߁C~̌`ɕK{ł<a href="#R8"><sup>8)</sup></a>i<a href="#F4">}4</a>jD
@זEȎiqɂẮCCNTFɂ킦CGDNFneurotrophindvłC͐_ȏɍۂĂłȂĈ̂̃nre[VɂĂ̏㏸邱ƂmĂ<a href="#R9"><sup>9)</sup></a>i<a href="#F4">}4</a>jDɁCVEGFǂ̐VĎĐ𑣐iƍlD̃^pN̎êт̉̃VOi`BnlƁCJAK-STATnCRAF-MEKnCPI3K-mTORnĐ𑣐iƂRZvg͗ɂȂĂ̂ȂDȂĈ悤ȍזEOqƍזEVOiƂ̘AւɂẮCĐɂď\Ɍ؂ĂƂ͂ȂD

<h2>3DĐ̑jQ@\FזEэזEȎjQq</h2>
@זȆjQq̂ȂłCPTENCSOCS3CRhoCKLF4CL^Ca<sup>2+</sup>`l͏dvłi<a href="#F4">}4</a>jDRho̓~GR^pN̉ɂċʂɂ͂炫CRhoLi[[/ROCKăAN`̏d𑣐iC̐L}<a href="#R10"><sup>10,11)</sup></a>DKLF4͓]ʗ}qłDKLF4mbNAEg}EXł͎_o𑹏̂̎Đ쐶^}EXɔחLӂɑi<a href="#R12"><sup>12)</sup></a>DL^Ca<sup>2+</sup>`l̏dv́CÂQɂ芴o_o̔΂Ƃۂ疾炩ɂȂ<a href="#R13"><sup>13)</sup></a>D̔΂̌́CL^Ca<sup>2+</sup>`l̃TujbgłCa<sub>v</sub>1.2̔̒ቺɂ̂łDۂɁCCa<sub>v</sub>1.2mbNAEg}EXł͎Đi<a href="#R13"><sup>13)</sup></a>DזE̊Đ}邱ƂL^Ca<sup>2+</sup>`l̃f[^͋[D
@זEȎjQq́C~GR^pNCKC_X^pNCveIOJC3̃JeS[ɕ邱ƂłD
@~GR^pŃCזEOɑ݂鎲Đ̑jQqƂėjIɂƂ悭ĂD̑ƂɂЂÂWallerϐɂC~GD̃~GɗR^pN̖[Ɛڂ邱ƂCĐjQ̈ɂȂD̍ĺC1988NC~GR^pNɑ΂R̂Đ𑣐iƂʂɂx悤ɂȂ<a href="#R14"><sup>14,15)</sup></a>D2000NC̍R̂FRNogo-Ał邱Ƃ񍐂ꂽ<a href="#R16"><sup>16)</sup></a>D܂ł́C~GR^pN͂NogoCMAGCOMgp3ŁCNogoêp75𒆊jƂê̕ɂCRho-RhoLi[[/ROCKȂǂ̃VOi`Bn邱Ƃ킩ĂDȂCNogoCMAGCOMgp̃gvmbNAEg}EXɂ_ô̂̎Đы@\̉񕜂ɂĂ͌O[vɂ茋_قȂĂC3̃^pN<em>in vivo</em>ɂ鎲Đ̑jQɊ֗^Ă̂ǂ͕Kmł͂ȂD
@KC_X^pN̂ȂłCqsemaphorinCephrinCslit͂ꂼɃO[v`邪C͐_o̍ۂ̃KC_X^pNƂċ@\΂łȂC_o̍ۂɂUꎲĐ̑jQɂ͂炭i<a href="#F4">}4</a>jD
@3ڂ̑jQqƂĂƂ݂ɒڂĂ̂CveIOJłDveIOJ̓RA^pNƂɋL钷ȓiORT~mOJjȂDveIOJɌORT~mOJƂẮCRhC`_CP^_Cwp_Cf}^_mĂDRhC`_̌veIOJ𑍏̂ăRhC`_veIOJƂԁDlɁCP^_veIOJCwp_veIOJȂǂ̑̂DЂƂ̃RA^pNɃRhC`_ƃP^_̗veIOJiP^_/RhC`_veIOJj邪CP^_ƃRhC`_͕ʁX̓łC̓̂ŃP^_ƃRhC`_ƂȂ邱Ƃ͂ȂD
@_o̍ۂɊꂽAXgOÁCKC_X^pNɂ킦veIOJYDjgَ̑ě㍪_oߍזE̎̓veIOJ܂ރjgZ[X̒ZfłȂƕ񍐂ꂽ̂C1990N̂ƂłD̂ƂɗpꂽveIOJ̓RhC`_уP^_܂ނ̂ŁCRhC`_P^_yfɂ蕪邱Ƃł̑jQ͎ꂽ<a href="#R17"><sup>17)</sup></a>DveIOJ͎ۂɑʂɂĎYĂ<a href="#R18"><sup>18)</sup></a>D2001N2002Nɂ́C<em>in vivo</em>ɂăRhC`_yf̓^ɂ莲Đы@\̉񕜂iꂽƂ񍐂ꂽ<a href="#R19"><sup>19,20)</sup></a>D̂悤ɁC܂ŃRhC`_SɍlĂC1990N̕񍐂ɂP^_̏dv͏ؖĂȂCM҂́C_P^_}EX̍쐻ɐC2006NC̃P^_}EXł͑̂̂ɐ_oˋN̐Li邱Ƃ񍐂<a href="#R21"><sup>21)</sup></a>DP^_}EX͂܂CҐ̂̂̎Đы@\̉񕜂i<a href="#R22"><sup>22)</sup></a>DɁCP^_yf̓^ɂCҐ̂̂̎Đы@\̉񕜂͑iꂽ<a href="#R23"><sup>23)</sup></a>D
@P^_邢̓RhC`_厖ƂĂCveIOJɂăRA^pN͒PȂ鑫ł͂ȂDRA^pNMϐAu~ƒuĐlHIȃveIOJ\z肷ƁCĐ̑jQ͎<a href="#R23"><sup>23)</sup></a>DɁCaggrecanCphosphacanCbrevicanCneurocanƂveIOJ̃RA^pNyfɂ蕪邱ƂɂĂCĐ̑jQ͎<a href="#R24"><sup>24)</sup></a>DāCRA^pNɂ铜̓K؂Ȓ񎦂Đ̑jQɂďdvƎv<a href="#R23"><sup>23,25)</sup></a>D

<h2>4D̎e</h2>
@~dystrophic endballƂ̈Ⴂ͂ǂɂ̂낤H@AtV̐_o̐~̌`ɂẮCǂ̍č\dvł<a href="#R26"><sup>26)</sup></a>DȂ킿C̖[͔ǂƕsɍč\邱ƂɂזEi`CEA̕ւނɂ͂炭Ƃɂ莲ĐɐiނƍlDɂĂǂ̍č\̏dvmFĂCɂDLK-1Ƃ̉̃VOi֗^Ă<a href="#R8"><sup>8)</sup></a>i<a href="#F4">}4</a>jDdystrophic endball_ȏɂĂ݂̂́Cǂ̍č\̕sSł<a href="#R27"><sup>27)</sup></a>DۂɁCǍč\̑jQ܂łmR_][͐~dystrophic endballւƕϊ邱Ƃł邵CCǂ̈艻܂ł^L\[dystrophic endbalľ`}ł<a href="#R27"><sup>27)</sup></a>DŏdvȂ̂́Cdystrophic endbalľ`̂̂͒_oɂƂƔ`ł͂ȂCiזEOqjɂ̂ł邱ƂłDƂ΁C㍪_oߍזE̖̎}͑Ɛ~`邪C}͑̂̂dystrophic endball`D㍪_oߍזEveIOJ̔Zxẑ|{ɂĔ|{ƁC<em>in vitro</em>ɂĂdystrophic endbalľ`U邱Ƃł<a href="#R18"><sup>18)</sup></a>i<a href="#F3">}3</a>jDۂɁCҐ̕ʂɂ̓veIOJWςĂC<em>in vivo</em>ɂĂveIOJ̔Zxz݂Ǝv<a href="#R18"><sup>18)</sup></a>D܂CɂveIOJ̎Ydystrophic endbalľ`̌łCĐ̑jQ̒SɂȂĂ\D
@ł́CveIOJ͂ǂ̂悤ȎêẴVOi_oɓ`BĂ̂낤H@܂ŁCRhC`_̎êƂāCě^`VzXt@^[[CNogoéCContactin-1񍐂ĂD
@PTPЂLAR͎ě^`VzXt@^[[̓Tut@~[ɑi<a href="#F4">}4</a>jCRhC`_ƌ@\IȎêƂĂ͂炭DPTPЃmbNAEg}EX͐Ґ̂̂̎Đы@\̉񕜂iĂ<a href="#R28"><sup>28)</sup></a>C<em>in vitro</em>ɂĂveIOJ̔ZxzɋtĎL邱ƂłDPTPЂ̓wp_ƂCCwp_ɂIS}[i<a href="#F5">}5</a>jDRhC`_ƃwp_PTPЂ̓N[̖ƉuOulhCɋIɌ邪CRhC`_PTPЂ̃IS}[NȂ<a href="#R29"><sup>29)</sup></a>i<a href="#F5">}5</a>jDɁCPTPЂƃwp_veIOJ͎ɂċǍ݂邪RhC`_veIOJ͍זEO}gbNXɑ݂D̂ƂCwp_veIOJƃVXŌIS}[PTPЂCזEOɎYꂽRhC`_veIOJƃgXɌƒPʑ̉CƂ@\ĂĂ<a href="#R29"><sup>29)</sup></a>i<a href="#F5">}5</a>jDʂɁCě^`VzXt@^[[͒Pʑ̂ł͊^ƂȂCIS}[ƂȂ邱ƂŕsƍlĂDāC̑̍ۂɃRhC`_veIOJƌ邱ƂɂPTPЂ̃zXt@^[[㏸邱ƂCdystrophic endbalľ`܂ł̈A̔̈ɂȂĂƑzDȂC̃zXt@^[[̊܂ވA̔ؖꂽ킯ł͂ȂDLARN[ɂƉuOulhCPTPЂ̂̂ƎĂCRhC`_ƌ<a href="#R29"><sup>29)</sup></a>DLARmbNAEg}EX̐_o̓RhC`_veIOJ܂ޔ|{ɂĂL<a href="#R30"><sup>30)</sup></a>i<a href="#F4">}4</a>jDLAR2ނ̑jQyv`h쐶^̐_o̐L𑣐iDɁCRhC`_veIOJCOS-7זEɔLAR̃zXt@^[[𘴐iDƂ낪CLAR2ނ̑jQyv`h́CꂼCLAR̃IS}[̑jQуzXt@^[[̑jQ̂߂ɊJꂽ̂łD܂CLARPTPЂƂ͋tɁCIS}[^ł\DLARPTPЂɂwp_veIOJуRhC`_veIOJ̊֌WɂẮCȂ錤KvłƎvD

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@veIOJɂ鎲Đ̑jQ</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/05/Kadomatsu-3.e005-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2014/05/Kadomatsu-3.e005-Fig.5.png&amp;caption=fig5-caption-text]

@NogoêNogoCMAGCOMgp̋ʂ̎êłDƂ낪CNogoe1Nogoe3̓RhC`_Ƃ<a href="#R31"><sup>31)</sup></a>DNogoe1Nogoe3̃_umbNAEg}EX͑̂̂̎ĐiĂi<a href="#F4">}4</a>jD́CNogoe1邢Nogoe3̒PƂ̃mbNAEgł݂͂ȂDNogoe1CNogoe3CPTPЂgvmbNAEg}EXł͂ɎĐiĂ邱ƂCNogoe1Nogoe3PTPЂ2̌n̓NXg[NĂ\D
@Contactin-1̓RhC`_ɂ_oˋN̐L̑iɂêƂē肳ꂽDRhC`_͂܂ŎĐ̑jQqƂĉĂĈRhC`_ÉCɂĂ͂ނ_oˋN̐Lɂ͂炭DContactin-1̓RhC`_EƌCRhC`_Eɂ_oˋN̐LContactin-1̃mbN_Eɂ}<a href="#R32"><sup>32)</sup></a>DKC_X^pNnetrin̎ނɂUɂɂ͂炭̂ƓlɁCRhC`_̎ނɂ莲̐L̑iɂjQɂ͂炭\DāCContactin-1<em>in vivo</em>ɂăRhC`_̋@\IȎêƂĂ͂炢Ă\D
@܂ŃRhC`_êɂďqׂĂCP^_êɂĂ͈ˑRƂĕsłi<a href="#F5">}5</a>jDҐ̂̂̎Đы@\̉񕜂̑iʂ́CP^_yfƃRhC`_yfƂœł<a href="#R23"><sup>23)</sup></a>D܂CM҂̗\Iȃf[^ɂƁC<em>in vivo</em>ɂĎĐ̑jQ̒SɂȂ̂́CP^_/RhC`_veIOJłƎvDāCP^_CRhC`_Cê3҂̊֌WƂĈ̔̕WɏdvłD

<h2>5DƐ_ỏY</h2>
@RhC`_veIOJ͎Đ̑jQɂƂǂ܂炸C_ỏYɂĂdvłDyj[ilbg̓puAu~z̉݃j[̓ʂȍזEO}gbNXłĈȐ̓RhC`_veIOJCqA_Ctenascin RłDʏCc̗ՊEɂ݂ȂoɈˑIȐ_oYCRhC`_yf̓^ɂ萬̂ɂċNƂł<a href="#R33"><sup>33,34)</sup></a>D܂Cc^̗_p^[RhC`_̃gXWFjbN}EXł́ĈɂĂoɈˑIȐ_oY݂<a href="#R35"><sup>35)</sup></a>D̂ƂĈɂĂyj[ilbg͗ՊE̗ĉ悤ɂ邢\ɂȂĂD̂Ƃ́CS̃RhC`_C_̃p^[ɂʂRhC`_̋@\hCyj[ilbǧ`ɂďdvłCoɈˑIȐ_oY𐧌䂵Ă邱ƂD
@_oY̊Ղɂ̓VivX̉YDRhC`_yfqA_yfAMPAê̑ւ̈ړ𑣐i<a href="#R36"><sup>36)</sup></a>D̑ړ͋_õVivXYɂďdvȃXebvȂ̂ŁCזEO}gbNX̐łRhC`_уqA_̃VivXY𕉂ɐ䂵ĂƂD܂CRhC`_yf̓VivX̌㕔`ˋNɂXpC̉їN𑣐i<a href="#R37"><sup>37)</sup></a>D̂ƂCRhC`_VivX`̗}qƂĂ͂炭ƂDɁCٓIȃnre[VƃRhC`_yf̕ṕCbgɂĐҐ̂̂̎̊p̉񕜂Ɍʂ𔭊Ƃ񍐂<a href="#R38"><sup>38)</sup></a>D
@ȏ̃f[^́CRhC`_̗}Iȋ@\́CĐɑ΂ĂłȂC_oYɂyԂƂĂD

<h2></h2>
@̍Đ𗝉邽߂ɂ́CזEэזEȎiqёjQqׂ̂ĂɔzKvDɁC_ô̂̋@\̉񕜂̋@\ǂƁC[̍זÊقт̏CC̐LCړȈꏊւ̓BCVivX̌`C@\IȐ_olbg[N̍ĕҁCƂ̃XebvzłD݂̂Ƃ뎡Ö@̂Ȃ_ȏɐVȎÖ@oȂCӂ܂ĕWIƂȂ镪q肵Ȃ΂ȂȂDRhC`_͎Đɂ킦ăVivXY}̂ŁCRhC`_WIƂ邱Ƃ͏\ɈӖ邾낤DC܂ŎgĂRhC`_yf͍׋ۂɗR̂łCqgɑ΂Ĕgp͂łȂ낤DāCRhC`_nRhC`_ê͂̑ւ̎iƂėLƎvDĈ߂ɂ̓RhC`_ê̐mȍp@\̉𖾂KvłDȂłP^_/RhC`_veIOJłȂCP^_ê̓Ɖ͂͌Ƃ̂łȂۑłDCajal1I܂ɂ̂悤ɂĂDgC_ȏ̂̂̍Đ\ɂȂƂȂC͌㐢̉Ȋw҂̓w͂ɂ̂ł낤hD

<h2> </h2>
<ol>
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<li id="R19"><span class='au'>Moon, L. D., Asher, R. A., Rhodes, K. E. et al.</span>: <span class="ti">Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC.</span> <span class='so'>Nat. Neurosci., 4, 465-466 (2001)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/11319553" target="_blank">PubMed</a>]</span></li>
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<li id="R31"><span class='au'>Dickendesher, T. L., Baldwin, K. T., Mironova, Y. A. et al.</span>: <span class="ti">NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans.</span> <span class='so'>Nat. Neurosci., 15, 703-712 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22406547" target="_blank">PubMed</a>]</span></li>
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<li id="R35"><span class='au'>Miyata, S., Komatsu, Y., Yoshimura, Y. et al.</span>: <span class="ti">Persistent cortical plasticity by upregulation of chondroitin 6-sulfation.</span> <span class='so'>Nat. Neurosci., 15, 414-422 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22246436" target="_blank">PubMed</a>] [<a href="http://first.lifesciencedb.jp/archives/4319" target="_blank">V_r[</a>]</span></li>
<li id="R36"><span class='au'>Frischknecht, R., Heine, M., Perrais, D. et al.</span>: <span class="ti">Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity.</span> <span class='so'>Nat. Neurosci., 12, 897-904 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19483686" target="_blank">PubMed</a>]</span></li>
<li id="R37"><span class='au'>Orlando, C., Ster, J., Gerber, U. et al.</span>: <span class="ti">Perisynaptic chondroitin sulfate proteoglycans restrict structural plasticity in an integrin-dependent manner.</span> <span class='so'>J. Neurosci., 32, 18009-18017 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/23238717" target="_blank">PubMed</a>]</span></li>
<li id="R38"><span class='au'>Garcia-Alias, G., Barkhuysen, S., Buckle, M. et al.</span>: <span class="ti">Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation.</span> <span class='so'>Nat. Neurosci., 12, 1145-1151 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19668200" target="_blank">PubMed</a>]</span></li>
</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">叼 iKenji Kadomatsuj</span>
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URLF<a href="http://www.med.nagoya-u.ac.jp/biochem/" target="_blank">http://www.med.nagoya-u.ac.jp/biochem/</a>
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