׋ۂƒǖƉu

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emailF<a href="mailto:kenya@rcai.riken.jp">{c</a>
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̈Zr[, <strong>2</strong>, e011 (2013)@<a href="http://dx.doi.org/10.7875/leading.author.2.e011">DOI: 10.7875/leading.author.2.e011</a>
Kenya Honda: <strong>The gut microbiota and immune system.</strong>

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<h2>v </h2>
@ǂ̓j[NȖƉun\zĂDł́CǊƉuזEƓɗ}\̋ƉuזEoX悭ݏoĂD́Cǂ܂܂Ȕ̐NƂ댯ɂ˂ɂ炳Ă̂ƓɁCIɐڂ閳QȐH⒰t[ɑ΂Ă͕sKvɖƉuȂ悤䂳Kv邽߂łDoX悭䂳ꂽǖƉun̍\zɂāCt[dvȂ͂炫Ă邱ƂXɖ炩ɂȂĂĂDt[\X̍׋ێ́CꂼقȂlɂǖƉunɉeDƂ΁CZOg׋ۂƂ΂ǂɏ݂׋ۂ̓}EX̏̔SŗLwɂTh17זE͂̕ɗUDŁCNXgWAɑǂɏ݂׋ۂ͐䐫TזE̐𑝉̋@\߂DāCt[̍׋ێ̍\ُ͖̈ƉüُւƂȂC܂܂ȎUDł́C׋ۂɉeč\zĂ郆j[NȏǖƉunɂďЉD

<h2>͂߂</h2>
@ǂ̊Ǎo͌C׋ۂɂƂ肫߂Č̂悢oCIAN^[Ƃċ@\ĂC1 g10<sup>11</sup>̃I[_[ŌC׋ۂ݂ĂDMނ̒ǂɂ͖1000킠邢͂ȏ̍׋ێ킪hƑݍpBĂC͑ŜƂĒt[Ƃ΂ĂDŋ߂̎V[NGT[pt[̉͂CǐC얞CAaCCdCǂȂǁCqĝ܂܂Ȏɂ锭ǂ̊󐫂ƁCt[̍׋ێ̍\ُ̈ƂڂɌтĂ邱Ƃ炩ɂȂĂĂD̒t[̍׋ێ̍\ُ̈́gdysbiosishƂ΂ĂC׋ێ̐̌iPjCȂ͂̍׋ێُ̈ȑC邢́Cʏ͗Dł͂̍׋ێ̌Ȃǂ<a href="#R1"><sup>1)</sup></a>DȂ킿Cdysbiosis͒t[̑ŜƂĕۗL`q̐CgŜƂċ@\Iɗh׋ۂ̍\Ƃ̂Ɠ`łDāC̎ɑ΂dysbiosis̉P߂ďdvȎÖ@ƂȂ肤邱ƂCւ̈ڐA̎Ȃǂ疾炩ɂȂDƂ΁C<em>Clostridium difficile</em>ƂɂU͌dysbiosisƂȂC҂̕ւ̈ڐAdysbiosisPC̎ɂĔɍʂ𔭊ƂՏ\Ă<a href="#R2"><sup>2)</sup></a>D
@CdysbiosisȂƂĉǂƌтCɎƌт̂C̗R͏\ɂ͖炩ɂĂȂD̗R̂ЂƂƂđz肳Ă̂́CƉun̍P퐫dysbiosisɂj]Ƃ̂łDȂ킿CƉun悤ȍ׋ێ킪DʂƂȂCtɁCƉun}悤ȍ׋ۂĂ邽߁C̑̂ƂĖƉunُ̈ȊUƂłDƉunH̐⒰׋ۂȂǖ{͉Ă͂Ȃ̂ɔCS̃oA@\ُ̈ƖIȉǂ炳̂ł͂ȂƍlĂi<a href="#F1">}1</a>jDwiɂƂÂCX̒׋ێ킪ǂ̂悤ɏh̖ƉunɉeĂ̂CҌȂʂɔcĂƂ錤ڂĂDȂ킿Cۃ}EXɂ̍׋ێ킾𓊗^C̍׋ۂ݂}EX쐻āC̍׋ێ̒PƂł̉e𒲂ׂ悤Ƃ̂łD̕@͌ÂmĂC^Qm͂邢̓^{\[16S͂gݍ킹邱ƂɂCptȃc[ƂĂӂђڂ߂ĂDۂɂ̕@ɂCt[\׋ۂꂼꂪقȂ邩ŏh̖ƉuזE̕@\ɉeĂ邱ƂXɖ炩ɂȂĂĂD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@dysbiosisƉ</strong>
iajgȒt[hDoNeCfBAɑ׋ۂуNXgWAɑ׋ۂLxɑ݂C׋ێ̑lC@\IɂĂDZOg׋ۂNXgWAɑ׋ۂȂǂɂTh17זEƐ䐫TזEƂoX悭ݏoC拭ȔS̃oAۂĂD
ibjgdysbiosishDHC`Iȑfɂ鉊ǁCR̎gpȂǂɂCDłׂoNeCfBAɑ׋ۂуNXgWAɑ׋ۂC׋ێ̑lC{݂͂Ȃ͂̍׋ێ킪Ƃdysbiosis𐶂邱ƂDdysbiosisTh17זE␧䐫TזEȂǂɂƉun̊Ɨ}Ƃ̃oXɈُ炵CS̃oA̔jƁC{͖Ɖunׂł͂ȂH̐⒰׋ۂɑ΂ُȊUD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/11/Honda-2.e011-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2013/11/Honda-2.e011-Fig.1.png&amp;caption=fig1-caption-text]


<h2>1DǖƉun</h2>
@ǂ̔S͊ƐڂĂa̍ő̐NoHƂȂ邽߁CƎ̃oAn\zĂDƂ΁C̃Nvgꕔ̊זËɂ́CזEq邩̂悤PanethזE݂DPanethזETollléiToll-like receptorFTLRjNODéiNODFnucleotide-binding and oligomerization domainjĔFCfBtFVȂǂ܂܂ȍRۃyv`hYāCa̐NhƓɏ݂׋ۂ̍\ɂeĂD܂Cǂ̏ɂ͔tזEigobletזEj݂CtזE͂StYĂD咰ł͂̔tזÊ͂炫ɂɌStw`D׋ۂ͔StẘOw܂ł͓荞ނƂł邪CזE̒̔Stw̓w̓`ǂɌĂ邽ߓ荞߂Cɂ׋ۂڂɏɐG邱Ƃ܂NjłD
@ǂɂ͔Ƀj[NȖƉuזE݂ĂDwɂ͏ԃpiintraepithelial lymphocyteFIELjƂȃp݂Dԃp͂CD8zTזEł邪זEQCECXȂǂ̔ɊזEɃA|g[VXU邱Ƃɂ芴̊ghłDw̉̔SŗLwɂ͖ƉuOuAYזETזEL̍זEƂđ݂CÂ猤ĂDɍŋ߁CTזEłBזEłȂRƉupTuZbgiinnate lymphoid cellFILCjǂɑ݂邱Ƃ񍐂ĂDRORtƂ]ʈq𔭌邱ƂƂO[v3 ILCƂ΂TuZbg̓C^[CL22YCǂ̏זE̍Rۃyv`h̎Y𑣐i邱ƂɂS̃oA@\𑝋ĂDCO[v2 ILCƂ΂TuZbg̓C^[CL5уC^[CL13YC񐶒ɑ΂銴hɏdvȖ͂ĂD2ILCTuZbg͂Ƃɏǂ̔Sɔɑ݂ĂD
@ǂ̔SɂCD4zTזE݂Ă邪C̑̓iC[u^TזEł͂Ȃ^TזE邢̓[^TזEłD̂Ȃɂ́CC^[CL17Y邱ƂƂwp[TזEłTh17זECƉun̗}ɂċ@\鐧䐫TזEiTregזEj܂܂DTh17זEѐ䐫TזE͊hɂ͂炭ƂƂɁCǂ̍P퐫̈ێɂďdvȂ͂炫D𖾂̕Cǂ̔S͂炳܂܂ȖƉuזEɂȃoAn\zCa̐NhƓɐH⒰׋ۂɑ΂ƉuȂ悤䂳ĂD
@׋ۂ͏ǖƉunɐ[eĂDe͖ۃ}EXp͂疾炩ɂȂĂDƂ΁Cۃ}EXł̓pCGCǗp߁CԖp߂ɏCBBזË您TזË̌`s\łDɁCSgɂCD4zTזEɑ΂鉞Th2זEɑ΂鉞ɂĂC̖ƉuOuE̔ZxSPFispecific-pathogen-freeC̗LQȕâȂjɂĎ炵}EXƔחLӂɍCȂ킿CAM[N₷ԂɂȂĂ邱ƂĂD܂Cۃ}EX̏ǂ̏͊OIȃXgXɑ΂ƎłCfLXg_ɂ钰̗Uɑ΂󐫂D܂ĈɂꂼqׂƉuOuAYזECTh17זEC䐫TזÉCCۃ}EXɂČĂDCÄُ́Cۃ}EXɒ׋ۂ𓊗^C邢́CSPFɂĐTԂɂ킽莔炷邱Ƃɂ萳ɉ񕜂<a href="#R1"><sup>1)</sup></a>D

<h2>2D׋ۂƖƉuOuAYזE</h2>
@ƉuOuAYזE͏ǂ̔SɓL̍זEƂČÂ猤ĂƉuזEłDǂ̖ƉuOuAYזE͎ƂăpCGɂ󒆐Sigerminal centerjƂxɑgDꂽ\ɂāCBזEBCNXXCb`C̍זEψقƂߒւ邱Ƃɂ萶ݏoDāC̉ߒɂTזÊ͂炫K{łDTזE̕⏕ƉuOuAzƂȂBזÉCpCG痣zւĂӂєSŗLwɂǂĂD́CƉuOuAzƂȂBזE͓ɃCeO47悤ɂȂ邪C̃KhłMAdCAM1ǂ̔SŗLw̌ǓזEɔĂ邽߂łDSŗLwɃz[~OƉuOuAzBזÉCɌ`זEւƕĖƉuOuAʑ̂Y悤ɂȂDƉuOuAʑ̂͏זE̊ꖌɔĂ|ƉuOuêƌCgXTCg[VXɂꑤǍoւƗADCSł͌Ǘp߂SŗLwɂTזEɁgˑIȁhNXXCb`ɋNĂ邱ƂmĂDCTזEˑNXXCb`ɂ萶ݏoƉuOuÁCRƉuɂvȉɂďdvł邪CTזEɈˑ̃NXXCb`ɂYꂽƉuOuAƔאea͒ႢD
@ƉuOuAYזE͖ۃ}EXɂĂ̐ɌĂDȂ킿C׋ۂ݂̑̕ɕK{ł邱Ƃ炩ɂȂĂDtɁCƉuOuA̎YɏQ̂AIDmbNAEg}EXɂĂ͒׋ۂ̍׋ۗʂُɑ邱Ƃ񍐂ĂD܂CƉu}^pNPD-1}EXł́ChEwp[TזËُȑɂ蓑ׂsSBזEcea̒ቺƉuOuAāCt[̍׋ێ̍\ُ̈łdysbiosis̐邱Ƃ񍐂ĂD̂悤ɁCƉuOuAƒ׋ۂ́C׋ۂƏǖƉunƂ݂ɉeȂP퐫ۂĂ邱ƂDƂȂĂD
@׋ۂ̂ȂłCZOg׋ہisegmented filamentous bacteriaFSFBj̓}EX⃉bg̏ɂĖƉuOuAYזE̐⒰ǂ̊ǍoɂƉuOuA̔Zx͂ɏ㏸邱ƂmĂ<a href="#R3"><sup>3)</sup></a>DۂɁCۃ}EXɃZOg׋ۂPƂŒ蒅邱ƂɂC̊ǍoɂƉuOuA̔Zx͌ɏ㏸DC咰ɂƉuOuA̎Yɂ̓NXgWAɑʂ̍׋ێ킪iIɂ͂炭ƂmĂDZOg׋ۂ͏ɒ蒅CNXgWAɑʂ̍׋ێ͑咰ɒ蒅邽߁Cꂼꂪ邢͑咰ƂʂɓٓIɖƉuOuA̎YiɂƍlDZOg׋ۂNXgWAɑ׋ۂɂƉuOuA̎Yi̕q@\͂܂̂Ƃ킩ĂȂD

<h2>3D׋ۂTh17זE</h2>
@ǂ̔Sɂ͕^邢̓[^CD4zTזEPIɑ݂D̂Ȃɂ́CC^[CL17AY邱ƂƂ邱ƂTh17זEƂ΂CD4zTזẼTuZbgɑ܂܂DTh17זE̎YC^[CL17ACC^[CL17FCC^[CL22Ȃǂ̃TCgJĆCזEɂ̎êĂDזECRۃyv`h̎Y𑣐iCǂ̔S̃oA@\߂D̂߁CTh17זE͔xہCa咰ہCFuhEۂȂǂ̕a׋ۂCJW_ۂȂǂ̐^ۂɑ΂銴hɂĕK{̖͂DƂ΁CC^[CL17AуC^[CL17F}EX͉FuhEۂɓaNDŁCTh17זE̎YTCgJC͍D̏WςƋǂЂNƂmĂDTh17זẺߏȊ͑dǁC֐߃E}`CǐȂǎȖƉu邢͎ȉǐ̔ǂ⑝ɂȂDāCTh17זE̐lHIɑ邱ƂłΊǂ̎ÂɂȂCtɁC̐邱ƂłΎȖƉu̎ÂɂȂƍlD
@iC[uCD4zTזETh17זEւ̕ɂ́CC^[CL6TGFƂ2̃TCgJCdvł邱ƂmĂDC^[CL6TGFTh17זE̕ɂĕK{̓]ʈqłRORt̔UD́CTGFɂhłRORt̔͗UDȂC̏ꍇɂ͓ɐ䐫TזE̕ɂ]ʈqFoxp3UCFoxp3RORtƌ̊}邽߁CTh17זEւ͗̕}Ă܂DɃC^[CL6邱ƂɂSTAT3CSTAT3ɂFoxp3̔}āCRORt̔ʂƂ̊㏸邱ƂɂTh17זEւƕƍlĂDC^[CL6TGFɂ蕪̗UꂽTh17זÉĈ܂܂ł͉ǂN̂ɏ\ȋ@\ĂȂDC^[CL6TGFɂhĂ邠CTh17זE̓C^[CL23ê𔭌悤ɂȂDāCC^[CL23̎hĂ͂߂āCTh17זE͉ǂN̂ɏ\ƂȂa̔rɂ͂炭DC܂ɉߏȃC^[CL23̎hTh17זEaIȍזEւƕĂ܂ƂmĂDۂɁCC^[CL23ë`qɂ1^isingle nucleotide polymorphismFSNPjƉǐƂɋւ̂邱Ƃ񍐂ĂDǐTCgJCłC^[CL1TNFTh17זE̕ɑ΂iIɂ͂炭ƂmĂCTh17זÉCǂɂ蕪iCǂɂ肳ɉǐƂȂזEƂD
@Th17זEɂēMׂƂ́Cǂ̔SŗLwɂƂ݂邱ƂłDtɂƁCSg̑ɂčPITh17זȆ݂̂͏ǂ̔SŗLwłD̗LQȕâȂSPFɂĎ炵Ă錒Nȃ}EXɂāCTh17זE͏̔SŗLwɂƂɑ݂DTh17זE͐シ̃}EXɂ͂قƂǑ݂ȂC炷ɂꑝDۃ}EX邢͍R𓊗^}EXɂĂ͒ǂ̔SŗLwɑ݂Th17זE̐͌ĂD̂ƂCTh17זE͒̕t[ɗRȂ炩̕qɂUĂ̂ƍlDۂɁC׋ۂɗRtWF邢͔񃁃`DNATolllêłTLR5TLR9ꂼꊈCTh17זE̕𑣐iƂ񍐂D܂ŁC׋ۂɗRATPɂTh17זE̕U邱ƂmĂ<a href="#R4"><sup>4)</sup></a>D
@SPFɂĎ炵}EXłC炵{݂ɂTh17זE͈̐قȂDƂ΁CčTaconic FarmsЂwSPF}EX̏ɂ͑Th17זEmFł邪CčJackson LaboratoryЂwSPF}EXɂ͏݂ȂD̂Ƃ́Cǂ̂悤ȍ׋ێłĂ׋ۂ݂΂킯ł͂ȂC̍׋ێ킪Th17זEٓ̕IɗUĂ邱ƂĂDāCTaconic FarmsЂ̃}EX̒ǂɂ͂̂悤ȍ׋ێ킪蒅ĂCJackson LaboratoryЂ̃}EXɂ͒蒅ĂȂƍlDTaconic FarmsЂ̃}EXJackson LaboratoryЂ̃}EX̒׋ۂrƂCTaconic FarmsЂ̃}EXɂ̓ZOg׋ۂ݂Jackson LaboratoryЂ̃}EXɂ݂͑ȂƂ炩ɂȂ<a href="#R5"><sup>5)</sup></a>DɁCZOg׋ۂ݂̂PƂŒǂɒ蒅}EX̏ɂđTh17זEmFCJackson LaboratoryЂ̃}EXɃZOg׋ۂ𓊗^Taconic FarmsЂ̃}EXƓlTh17זE̕UꂽDȏォCZOg׋ۂTh17זE͂̕ɗU׋ۂłCJackson LaboratoryЂ̃}EXɂďTh17זEȂ̂̓ZOg׋ۂ݂ĂȂ߂ƍlꂽD
@ZOg׋ۂ͕߂`Ԃ@ۏ̒׋ۂłĈ̖͂̓IȌ`ԂɗRD̏זEɋڒĐ邱ƂƂĂC̐ڒɂCƉuOuAYזETh17זEȂǂ̏h̖ƉuזEɉeĂƍlDZOg׋ۂ͚MށCށC঒ށCށCȂǑ̐̒ǂɑ݂ĂD}EXуbgɒ蒅ĂZOg׋ۂ̃QmǂČʁCZOg׋ۂ̓NXgWAɑƍlĂ<a href="#R6"><sup>6)</sup></a>DQmTCY͏C邢͑BɕKvȑӌoH̑hɈˑĂƍlDtWF₢̐ڒqCɂ菬̏זEɐڒƍlD̐ڒA~ChAȂǉǐ^pN̎YUCꂪTh17זE̕ɂȂƑz肳ĂD
@ZOg׋ۂɂTh17זE̗̕ÚCRۃyv`h̎YiȂǏǂ̔S̃oA@\߂邱ƂɂȂChɂĕa׋ۂ̊ɑ΂R߂D̂߁CZOg׋ۂǂɑ蒅}EX́CƂ΁Ca׋<em>Citrobacter rodentium</em>̊ɑ΂RDȂ킿CZOg׋ۂɂTh17זÉ̕ChɂƂghhƂł͗LvłƍlDŁCƂ΁C`IɎȖƉȗfƃZOg׋ۂɂTh17זE͎̕ȖƉu̔ǂɂȂ\DۂɁC֐߉f}EXłKBxN}EX͖ۂ̊ł͊֐߉}CZOg׋ۂ𓊗^Th17זE̕鋭͂Ȋ֐߉U<a href="#R7"><sup>7)</sup></a>D܂Cdǂ̎}EXfɂĂZOg׋ۂ̒蒅Ǐ̈ɂȂ邱Ƃ񍐂ĂDȂ킿CgȖƉu邢͎ȉǁhƂɂĂ̓ZOg׋ۂɂTh17זE̕͏hɂƂLQł邱ƂɂȂDZOg׋ۂ͑̐̒ǂɑ݂邪Cqgł݂̑Ă<a href="#R8"><sup>8)</sup></a>DZOg׋ۂ̂́C邢́CZOg׋ۂƓ̋@\qg̒׋ۂ𓯒肵CɁC𐧌䂷@Jł΁Cǂ⎩ȖƉu̐VȎÖ@ƂȂ\D

<h2>4D׋ۂƐ䐫TזE</h2>
@䐫TזEiregulatory T cellFTregjCD4zTזẼTuZbĝЂƂłC]ʈqFoxp3𔭌邱ƂƂDȍRɑ΂Ɖus̈ێChɂƂLQȉߏȖƉu̗}ɂ͂炭K{̍זEłDFoxp3}EXɂ͐䐫TזËُ̕ɂv̑Qiǁjώ@邪C䐫TזËړɂ肻̏Ǐ͗}D܂CqgɂĂC<em>Foxp3</em>`q̕ψقVIPEXǌQƂ΂Sg̎ȖƉǔƂȂ邱ƂmĂD䐫TזE͑SĝׂĂ̊튯ɑ݂C̊CD4zTזÊ悻10߂Dɑ΂Cǂ̔SŗLwɂĂ͐䐫TזE̊ɍCCD4zTזE30ȏɒBDǂɑ݂鐧䐫TזE͐H̐ɑ΂Ɖue⒰׋ۂɑ΂ƉuwIȕsȂǂɂƑz肳ĂDۃ}EXɂđ咰ɑ݂鐧䐫TזE̐ɌĂ邱ƂC咰ɂ鐧䐫TזE̕⑝Bɒ׋ۂ݂̑傫^ĂƍlD䐫TזEɂ́CBɂĂFoxp3zזEƂĕC鋹B䐫TזEitTregזEjƁCʏCD4zTזEƂĖɑ݂̂Foxp3zƂȂC閖䐫TזEipTregזEj2ނD咰̐䐫TזEɂ́C׋ۂɂ蕪̗Uꂽ䐫TזE܂܂ĂƍlĂDB䐫TזEƖ䐫TזEƂłTזEễpgACȂ킿CFłRقȂĂDāCǂɂĖ䐫TזE̕Û́CB䐫TזEł̓Jo[Ȃ悤ȍRɑ΂ĂƉu𐧌ł悤ɁĈldvȕq@\łƍl<a href="#R9"><sup>9)</sup></a>D
@̗LQȕâȂSPF}EXɃoR}CV𓊗^Ɛ䐫TזE̐͌D܂CSPF}EX̕ւNzɂ菈Ėۃ}EXɓ^Ɛ䐫TזE̋͂ȕ̗Uώ@邱Ƃ<a href="#R10"><sup>10)</sup></a>CoR}CV󐫂Nzϐ̒׋ۂC䐫TזE̕ɂ׋ێłƍlD׋ۂ̂Ȃł̂̓NXgWAɑ׋ۂłDۂɁC}EX̏ǂPꂽ46<em>Clostridium</em>׋ۂ𖳋ۃ}EXɌo^ƁC䐫TזÊ߂ċ͂ȕ̗Uώ@<a href="#R10"><sup>10)</sup></a>DC<em>Lactobacillus</em>׋ۂ<em>Bacteroides</em>׋ۂȂǂ̓^ł͂̂悤Ȑ䐫TזȆ͔F߂ȂDāC׋ۂ̂ȂŃNXgWAɑ׋ۂ䐫TזE̕ɔɏdvȖ͂ĂƍlD46<em>Clostridium</em>׋ۂ͑咰ɑ݂鐧䐫TזEɂC^[CL10̎YCTLA4̔iDC^[CL10͉Ǘ}̃TCgJCłCC^[CL10邢̓C^[CL10ê̌ɂ蒰𔭏ǂ邱ƂmĂD܂CCTLA4͊TזE̗}ɂ͂炭êłCCTLA4}EX͑Sg̎ȖƉu𔭏ǂ邱Ƃ񍐂ĂDāC46<em>Clostridium</em>׋ۂ͑咰ɂĐ䐫TזE̐𑝉ƓɁC̋@\iƂD
@}EX̏ǂɗR46<em>Clostridium</em>׋ۂƓ̐䐫TזE̗̕U\׋ۂ́Cqg̏ǂɂ݂<a href="#R11"><sup>11)</sup></a>D{llj{eBAɗRւ̎𖳋ۃ}EXɓ^ƁC䐫TזE̗̕Uώ@D̕ւNzɂ菈Ėۃ}EXɓ^ƁCɋ͂Ȑ䐫TזE̗̕Uώ@<a href="#R11"><sup>11)</sup></a>D䐫TזE̕}EX̉ӕ̓eēxNẑC2{Ɋ߂ĕʂ̖ۃ}EXɓ^ĂClɐ䐫TזE̗̕Uώ@D̉ߒԂĐ䐫TזE̗̕U\׋ۂZk}EX̉ӕ̓e|{邱ƂœꂽC17̃NXgWAɑ׋ۂɂC͂萧䐫TזE̗̕U\D}EXɗR46<em>Clostridium</em>׋ۂCqg̕ւPꂽ17̃NXgWAɑ׋ۂCNXgWANX^[̂CNX^[XIVaCNX^[IVCNX^[XVIIIɑĂ<a href="#R10"><sup>10,11)</sup></a>Dqgɏ݂׋ۂŃNXgWANX^[IVɑ<em>Faecalibacterium prausnitzii</em>́C<em>in vitro</em>̔|{nɂāCqg̖̒PjC^[CL10̎Y𑣐i邱ƂĂDǐ̊҂Ags[畆̊҂ɂẮCt[̑Ŝɂ߂NXgWANX^[IVуNXgWANX^[XIVåĂ邱Ƃ񍐂Ă<a href="#R12"><sup>12)</sup></a>DNXgWAɑ׋ۂǂɖLxɑ݂}EX͑咰ɂĐ䐫TזECCfLXg_ILT]ɂU钰ɑ΂RD܂CSg̖ƉuOuEւ̉уAM[}ꂽԂɂD͂CNXgWAɑ׋ۂɂ鐧䐫TזE̗̕Uqg̖Ɖu̐ɖ\ĂCȂ킿CNXgWAɑ׋ۂ̕[Ö@AM[⎩ȖƉu̎Ö@ƂȂ肤ƍlD
@NXgWAɑ׋ۂ͂ɖӒы߈ʌ̏זE̋ߖTɑw`悤ɂĒ蒅D蒅̗lԂCNXgWAɑ׋ۂ͏זEɋeĂƍlDۂɁC}EXɗR46<em>Clostridium</em>׋ۂ݂̂𒰊ǂɒ蒅}EX̑咰̏זEP̈`qԗIɉ͂ƁCTGFȂǐ䐫TזȆB╪𑣐i^pNR[h`q̔ĂD܂Cqg̕ւPꂽ17̃NXgWAɑ׋ۂ݂̂𒰊ǂɒ蒅}EX̉ӕ̓e̐o𒰂̏זEɂ킦ƁCTGF̎Y̗Uώ@DāCNXgWAɑ׋ۂ͒ǂ̏זEhC咰ɂĐ䐫TזE̕UĂƍlD

<h2></h2>
@ǂɂ͔Ƀj[NȖƉuזE݂i̍זETuZbg܂݂ƍljCƉuזE̕@\͒׋ۂɂ[eĂDt[`׋ۂ͌XقȂlɂ肻ƉuזEɉeĂƍlD̃oẌُ킪ɂȂƑz肳Ăi<a href="#F1">}1</a>jC̎ɂĂ͒t[̉ς{ÂƂȂ肤邽ߌiłDt[̉ς̂߂̐׋ۂ̕[Ö@͌ÂsĂCvoCIeBNXƂĕyĂDC܂ŗpĂvoCIeBNX͐̂ւ̉ewWɒPĂ킯ł͂ȂCPɔ|{ȒPł_ɑϐłƂRɂIꂽ̂Dŋ߂ł́C҂̕ւ̈ڐAɌʓIɎÂł邱ƂĂ邪Cւ̂̂̓^͖m̃ECX̊ȂǊ댯ƂȂ߁Cɑ׋ێɓKvDŏЉZOg׋ۂNXgWAɑ׋ۂ́Cꂼˏo@\ĂD̂悤ȁCǂɏ݂ĂȂĥזE̕@\֐lדIɕς邱Ƃ̂ł׋ێ킪C̃voCIeBNXɂȂƍl<a href="#R13"><sup>13)</sup></a>D܂Ct[̍׋ێ̍\ُ̈łdysbiosis̉ṔCPƂ̍׋ێ̓^ł͍łƍlDhւ̉e̔cł̍׋ێ̑gCCVvoCIeBbNXƂĊJĂ̂ƍlD

<h2> </h2>
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</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">{c iKenya Hondaj</span>
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URLF<a href="http://www.riken.jp/research/labs/ims/gut_homeost/" target="_blank">http://www.riken.jp/research/labs/ims/gut_homeost/</a>
</div>
? 2013 {c  Licensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
