ߖOaȊẘJ

<strong>㓡 S</strong>
iw` `\`j
emailF<a href="mailto:ygoto@protein.osaka-u.ac.jp">㓡S</a>
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̈Zr[, <strong>2</strong>, e002 (2013)@<a href="http://dx.doi.org/10.7875/leading.author.2.e002">DOI: 10.7875/leading.author.2.e002</a>
Yuji Goto: <strong>Exploring the supersaturation-dependent life science.</strong>

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<h2>v </h2>
@ߖOa͎REɂ߂ĕՓIȕwۂłCXĈɂ錋΁C^pN͂߂Ƃ邳܂܂ȕ̌CRjNĈ݂ɂ܂łDߖOaԂɂĂȂ炩̌ŊjƁCߖOa͉Cn͌͏oĕtԂɂD^pNȊw̏dvȃe[}łA~Chۂ̌`CߖOaɂxzꂽ^pN̐͏oۂłƍlƂ킩₷DߖOa͌āgȌہhł͂ȂCLۂxzdvȈqłƍlDȊŵ܂܂Ȍ̈ɂĉߖOaƂ̉Ɋւ錤sĂDƗZ邱ƂɂCߖOảɂ݂悤ȁCȊw̔IȐiW҂łD

<h2>͂߂</h2>
@g^pNƂ͉HhƖꂽƂCƓ邾낤DؓHĈ̋@\CA~m_yv`hłȂ󍂕qCȂǂȂǁCꂼ̋◧ɂ肳܂܂ȉ񓚂lDȊw̗jɂẮC^pŃiM_ɂjϐÏW鐶̕łi<a href="#F1">}1</a>jD1940NCɂēƑnIȃ^pNWJWu̘_ǂނƁCC^pN̕ϐ͋ÏWɓƂ킩<a href="#R1"><sup>1)</sup></a>i1995N Čf<a href="#R2"><sup>2)</sup></a>jDWúCfaIݍp̊TOmȂŁC^pN̋@\\ilCeBu\j͌ɕCG钁\łƍlDāCϐƂ̓lCeBu\艻鑊ݍpĕsKȍ\ƂȂ邱ƂłČʁC^pN͋ÏWƍlD́C^pÑlCeBu\ƕϐ\̗̖{ĂĂDHiƂẴ^pNɂẮCÏW̓^pN̖{Iȓł邱ƂCXCD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@^pN̗jƓW]</strong>
\CC@\̌CߖOaȊẘJցD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.1.png&amp;caption=fig1-caption-text]

@1950NC~IOrCwOrC]`[͂߂Ƃ^pNX\Ɩ炩ƂȂC^pN̋@\\ɂƂÂ邱Ƃ͂܂<a href="#R3"><sup>3)</sup></a>DX͂𒼐ڂ̌iƂȂɂĂCzuȂǂ̕wIȎ@C邢́CSxȂǂ̗̗͊wIȎ@pă^pN̍\ꂽĎ@̂قƂǂ́gnthKvƂ߁CÏWɂ͌rĂD
@w`1958NɐݗꂽCM҂̏g`\`h̃[c͂̐ݗƓɔ3̌̂ЂƂg`ntwhɂD̂̂ƂCvȌΏۂ̓^pNntłDɂ̂Ȃ^pNntp邱ƂɂC^pN̍\Ƌ@\̌iWƂ͋^ȂDC^pN̖{IȓłÏW͔rĂCɂ͎Ƃ݂ȂɂD
@M҂́C1970N㔼^pNɂĂDC^pN̋ÏW͌̏QȊOȂɂ̂łȂD1980NCR̂̃hC̃WXtBhҌ̍\𒲂ׂ<a href="#R4"><sup>4-6)</sup></a>DҌ^pN͂΂΋ÏWDÏW̗R͂͂肹CÏWȂƂ˂Ɋ肢ȂsD1987Nɂ́CgeOr[ԁhƂ΂钆ԓIȏԂ̍\萫<a href="#R7"><sup>7,8)</sup></a>DIUɂ胂eOr[Ԃ̃TCY𑪒肵悤ƂCU𑪒肷ƁCN^}[[͌Ԃɑ傫ȋÏŴ`ĂDق̃^pNł̓eOr[Ԃ̃TCY񍐂Ă̂ɃN^}[[͂ɂĂ܂łȂCƒQƂȂD

<h2>1DghA~Ch\w</h2>
@̂悤ȏ󋵂́C1990NɓƑ傫ςĂi<a href="#F1">}1</a>jD^pN҂͋ÏWɑΛȂȂD咰ۂȂǂɔ^pNCN[W{fBƂ΂ÏŴ邱Ƃ͖łȂ<a href="#R9"><sup>9)</sup></a>D^pN̋ÏWh^pÑtH[fBO肷ʂ̃^pN݂̑邱Ƃ炩ɂȂCqVyƂTOm<a href="#R10"><sup>10-12)</sup></a>D
@ɂ́C^pN҂͈w̏dvȃe[}łA~Ch[VX₻̌łA~ChۂɒڂDA~Chۂ̓V[g{\Ƃ镝10 nmCmɂyԍׂۂłCA~Ch[VXƑ̂邳܂܂ȎɂăA~ChЂN<a href="#R13"><sup>13-15)</sup></a>DA~Ch[VXɂ̓AcnC}[aC̓A~Ch[VXCA~Chj[p`[CII^AaȂ20ވȏオCA~Chۂ͂玾̌ƍlĂDIł̂́C1995NɎЉЂNEVCȏ]ǁiBSEjł<a href="#R16"><sup>16,17)</sup></a>DA~ChۂƋʐ^pNُ̈ȋÏŴEVCȏ]ǂ͂߂ƂvIåł邱ƂꂽDvIaA~Ch[VX̂ЂƂłDʂɁCA~Ch[VXł̓A~ChۂזEOɒ邪Cp[L\ał̓VkNČ`A~ChۂƗގۏ̋ÏŴזEɒ<a href="#R18"><sup>18)</sup></a>DA~Chۂɑ\ُȋÏW~XtH[fBO܂܂Ȏ̌ƂȂĂ邱Ƃ炩ɂȂCtH[fBOaCRtH[VaC^pNُÏWCȂǂ̗pꂪ񏥂ꂽ<a href="#R14"><sup>14,15)</sup></a>D^pN̍\tH[fBOĂ̌҂̌ɎQD
@2000NOɂȂƁCA~Ch\w䓪DA~Chۂ₻̑ÓC邢́C̃IS}[̍\邱ƂɂCÏW̕q@\A~Ch[VX̔ǋ@\𗝉悤Ƃ錤ɂȂ<a href="#R19"><sup>19)</sup></a>i<a href="#F1">}1</a>jDƂ킯CÏŴłsƂłőNMRЗ͂𔭊<a href="#R20"><sup>20,21)</sup></a>DA~Ch^pÑRAƍl鐔c̃yv`h͔`CꂪA~Ch\̃fƂĒ񏥂ꂽ<a href="#R19"><sup>19,22)</sup></a>DM҂C̓A~Ch[VX̌^pNł<sub>2</sub>~NOuAcnC}[ǎ^pNłA~Ch^pNޗƂāCntNMR <a href="#R23"><sup>23,24)</sup></a> u<a href="#R25"><sup>25,26)</sup></a> Ȃǂp\wIȌWJĎɂC{͕q̓ŃtH[fBOĂ^pNCϐqԂŃV[g`邱ƂɂCA~Chۂ`Ă悤炩ɂȂĂi<a href="#F2">}2</a>jD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@^pÑtH[fBOƃA~Chۂ̌`</strong>
iajRGlM[vt@CƁCꂼ̏Ԃ̍\D
ibjgݖ؃pYɂC[WD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.2.png&amp;caption=fig2-caption-text]


<h2>2DA~ChƌƂ̋ʓ_</h2>
@A~Chۂ̍\wIȌƕsāC^pÑtH[fBOƑΔ䂳dvȓ炩ɂȂD1960NCAnfinsenɂCIȏɂălCeBu\͔M͊wIɂƂȍ\ł邱Ƃꂽ<a href="#R27"><sup>27)</sup></a>i<a href="#F2">}2</a>jDtH[fBO͂΂ΕϐԂƃlCeBuԂƂ̓Ԃ̓]ڂƂċIɐisDɑ΂āCIȃA~Chۂ̌`͈̒xԂ̂̂ˑRɋNDCłۂV[hƂăm}[̗ntɂ킦邱ƂɂCxԂZkȂ肷邱Ƃł<a href="#R25"><sup>25,28)</sup></a>D܂Cǰ`ی`̗ƂȂĂD
@M҂́CSˌƃA~ChɓٓIȌuFfł`ItrTƂgݍ킹邱ƂɂCA~Chۂ1ۂ̃xŊϑ@m<a href="#R25"><sup>25,29)</sup></a>i<a href="#F3">}3</a>jD̕@ɂ蓾ꂽ摜́Cj`Lɔׂɂނ悭\킵ĂD܂Cȏ̍ɂۂ̌`Ԃ͂΂ΈقȂC͑^Ƃ΂邪Č`Ԃ̐ۂV[fBOɂ`d邱Ƃł<a href="#R30"><sup>30)</sup></a>D

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@A~Chۂ̌</strong>
iajȌ`D
ibjtLVuȌ`D
A~Ch(1-40) ̌`A~ChۂɂāCA~ChɓٓIȃ`ItrŤuSˌuɂώ@Dȏ̍ɂقȂ`̐ۂώ@ꂽD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.3.png&amp;caption=fig3-caption-text]

@ȏ̃A~Chۂ̌`Ƃ܂l̓ۂvׂ邱ƂłDȂ킿Č`ł<a href="#R31"><sup>31,32)</sup></a>DOɐ̒P̌`Ԃ̓A~ChۂƂ͑傫قȂDC҂̌`̓͂܂łDA~Chۂ̕q\邢͌q\͂킩ȂĂC̖{͌`Ɠł邱ƂzłD
@̌́CߖOaԂɂĊj邱Ƃɂ`DA~ChۂC^pN̉ߖOantꂽƂɐ͏o\`Ԃł邱ƂꂽDvIa̓^pNɂ`dD܂CvIaɂ͑^ïقȂ\^jDƂɁCA~m_zvI^pNƂȂvIaɂCh⊴oHɂ葽^̂邱ƂĂ<a href="#R17"><sup>17,33)</sup></a>DvIa̓`dz̃vI^pN^CƂɕsvcȂƂƍlĂ邪CvI^pN`銴̍\Č`Ɠ^`dNĂƍlƁCȂ͒̕ϓIɗłD
@IȃA~Chۂ̌`͗nt̕Iȏɑ傫ˑ邱ƂmĂDƂɁCntÒuƊj`͂ȂȂNȂDÒuɂĉJĎIȃA~Chۂ̌`𒲂ׂ邪Ĉ悤Ȏ̍ČmF邱Ƃ͗eՂłȂDŁCIȃA~Chۂ̌`ɂĂ͗nt͂C邢́CUƂ邱ƂʓIɍsDƁCÒuɔ׃A~Chۂ̌`͊mɑ܂Dł́C`ɂj`͂ɂ董i邱Ƃ悭mĂ<a href="#R34"><sup>34)</sup></a>D̓_ʂĂD

<h2>3DgɂA~Chۂ̌`</h2>
@nt̂͂񂪃A~Chۂ̊j`ЂN̂ł΁Cg̏Ǝ˂ɂĂľʂ҂łƍl<a href="#R35"><sup>35)</sup></a>Dg2wcȏ̍gȂ鉹głCẽZT[Cj󌟍CEۂȂǂ܂܂ȗprɗpĂDgGNgjNX⒴gwƂ̈͊e̎YƂɒĂDntɒgƎ˂ƃLre[VƂ΂~N̋CAi<a href="#F4">}4</a>jDꂪfMkďłƂC̊ƂƂOHWJ𐶂D܂CLre[V͗nt̃~NȗЂNDWJ͂܂܂ȉwЂNC~Nȗ͗nɑ΂Cf◱qȂǕIȗ͂𔭊DA~ChvIł͒g̋AWe[V͂𗘗păV[h𕪒fȃV[h̐𑝂₷ƂʓIɍsĂ<a href="#R28"><sup>28)</sup></a>Dۂ̐L̓V[h̖[ŋN̂ŁCV[hϐ邱ƂȂؒf邱Ƃł΁C1̐ؒfɂV[h̊Zx2{ɂȂDvI^pŇɂẮCDNA𑝕邽߂PCR@ƓlȁCg𗘗pvIV[h̑񍐂Ă<a href="#R36"><sup>36)</sup></a>D

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@gɈˑwƃA~Chۂɑ΂</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.4.png&amp;caption=fig4-caption-text]

@_ϐ<sub>2</sub>~NOuɑ΂钴g̏Ǝˎsi<a href="#F5">}5</a>jDÒu܂܂ł͉NȂɂāC^̒gƎˑupă^pNntɒgƎ˂DāCA~ChɓٓIȃ`ItrŤuώ@̂Ƃ킹āCUɂnt̏Ԃώ@DƁC1ԌC`ItrŤuƌU̓˔Iȏ㏸ϑꂽDqԗ͌ɂ萶𒲂ׂƁCZA~ChۂłĂD̂悤ɂĂłZۂ_ϐ<sub>2</sub>~NOuɑ΂1/10ʁCgƎ˂ȂɂĂ킦ƂC`ItrŤuƌU͂ɏ㏸D܂Cgɂ莩IɌ`ꂽZۂ̓V[hƂĂ̔\͂ĂDȏ̎C_ϐm}[̃<sub>2</sub>~NOuɒgƎ˂邱ƂɂA~ChۂVɐ邱Ƃ炩ɂȂD

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@gɂ<sub>2</sub>~NOũA~Chۂ̌`</strong><a href="#R35"><sup>35)</sup></a>
_ϐ<sub>2</sub>~NOui0.3 mg/mlC0.1 M NaClCpH 2.5jɑ΂C^̒gƎˑupāC2Hz̒g1Ԃ̏ƎˁC9Ԃ̒~̂ԂŏƎ˂DA~ChɓٓIȃ`ItrŤuqԗ͌ɂώ@ƂC1Ԃ̒xԂ̂̂A~Chۂ̌`͂܂Ƃ炩ɂȂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.5.png&amp;caption=fig5-caption-text]

@LA~Chۂɑ΂Ēg̏Ǝ˂ÂƐۂ͒fЉ<a href="#R28"><sup>28)</sup></a>DŁCۂUʂƐۂjӂʂ̗͂炭Ɨ҂肠CZċώȃA~ChۂłƊ҂DۂɁCg̏Ǝ˂ÂƖ150qiqʖ200j̃<sub>2</sub>~NOu\rIώȃA~Chqł<a href="#R37"><sup>37)</sup></a>D̂悤ȃA~Chq͐ɋώɕU邱ƂeՂłD݂łCA~Chۂ̍\wIȌ͐ۂqʂłƂƂɒsψł邽ߗeՂł͂ȂD̏ċώȃA~Chq͗ntNMRȂǃ^pNntΏۂƂ\̌ɗLł<a href="#R38"><sup>38,39)</sup></a>D

<h2>4DߖOaƂVȎ_</h2>
@A~Chی`̖{^pN̉ߖOa̐͏oł邱Ƃ͂܂Ȃ<a href="#R32"><sup>32)</sup></a>Dɗninj̗nxߖOa͗ntw̌ΏۂłDA~Chۂ𗝉ɂ͈ʓIȗn̉ߖOaƐ͏oɊւmOɂƂKvłDňƂȂ͏oۂ͗n̔ZxnxƂɋNDƂɉwHw̕ł͏͂Ƃ΂C̊̕{łDƂ΁C~Eo͍Őɂ悭n邪CxƗnx͉ߏ̃~EoƂĐ͏oD
@^pNł܂ľۂNi<a href="#F6">}6</a>jDjg̗]`[pH 4t߂ŉ݂ȂƂ悭nCOaԁï1jɂDNaClȂǂ̉킦Ɨnx͉Ct_Iɂ͗nxߏ̃]`[͌ƂĐ͏o<a href="#R40"><sup>40,41)</sup></a>DCnxĂIȊj`̋NȂߖOa݂C͏ԁï2jƂ΂DԂŌ͏oɂ̓V[hKvƂDV[hɂ茋JnƁCn̔ZxnxɓȂ܂Ō͐istԂƂȂĒ~DZxɍ߂ƎIȊj`̋Nsԁï3joDsԂł͈̒xԂ̂̂CjDɉߖOaȂƉߖOaێ邱ƂłȂȂCxԂƂȂj͂Ŕï4jDʂɔĵꂼꂪ\ɐȂɗn̐͏o͏IĂ܂CʂƂāCł͂Ȃs`iAt@XjȋÏWD̂悤ɂĂł^pN̕s`ÏW͕sKɑݍpČŒ艻KXԂɑ<a href="#R41"><sup>41)</sup></a>D^pN̐ɗp闰áC܂Ƀ^pÑKXԂ肾ĂDȏČ`ɂ͉ߖOaK{łCߖOaƌ`͕\̂̌ۂƂD

<a name="F6"></a><div id="fig6-caption-text" style="display: none;"><strong>}6@ߖOaƏ</strong><a href="#R41"><sup>41)</sup></a>
iajjg]`[pH 5t߂ɂ鉖ZxɈˑΔeD
ibj<sub>2</sub>~NOupH 2ɂ鉖ZxɈˑ\Ԃ̑}D
n̔ZxtnxႢƂ͖Oaԁï1jłDߖOaԂ́CIȊj`̋NȂԁï2jƁCxԂ̂̂IȊj`ւƂЂÂ̋Nsԁï3jȂDߖOaxi݃KX]ړ_ƁCɕs`ÏWiKXԁj𐶂ï4jD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.6.jpg" target="_blank">[Download]</a></div>[hs_figure id=6&amp;image=/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.6.png&amp;caption=fig6-caption-text]

@ƕs`ȋÏWC邢́CKXԂ̐͏óCő̂Ɖt̂Ƃ̑]ڂɂĂ͂܂DƂ΁C͓_PCfiSiO<sub>2</sub>ǰłD̏ŗn̂팋gJĂƈ琬ƐlHłDV[fBOƓłDɑ΂āCnZԂŗpƕs`ȋÏWɑgKXԁh̐ΉpKXłDΉpKX͉Ö𑪒肷镪xvp̃ZɎgD̂悤ɁC_PCfł͌ƃKXԂƂʂč쐻邱Ƃ\łDCKXȂǂ̃KX́CƓ_PCf听Ƃ邪C܂܂ȕƂ̍łDƂẮC_igEiNa<sub>2</sub>OjC_}OlVEiMgOjC_JVEiCaOjȂǂD݂邱Ƃɂ_PCf͌ɐ邱ƂłCpƂɁgKXԁh̃KXɂȂD܂Cɂẑ߃KX͉O𓧉߂ȂDCA~Chی`̂܂܂ȑjQ܂JĂ邪C̑̓A~Chۂ̌`jQs`ȋÏW肾<a href="#R42"><sup>42)</sup></a>D̂悤ȑjQ܂̌ʂ̓KXɊ܂܂镛̌ʂƋʂĂD
@ߖOa͂߂ĈʓIȎRۂłCɂ܂܂ȗ邱ƂłDJ͐C̉ߖOa͂܂D̉ߗp\IȗłCjłƕX͐D܂CqgɂĎЂNAH΁C_΁CɕȂǂ̌΂̉ߖOaƈ̂ƂȂĂDAH΂̓VE_JVEC_΂̓RXe[Cɕ͔A_̌ɂNDRjNC͐ł͐΂ɐHׂ邱Ƃ͂łȂČ̓RjNCɊ܂܂VE_JVE̐j󌋏ɂDTgČsłYCLssƐhƂ邪R͂ƓłD̂悤ɁC͉ߖOaƂ͂ƂĐ镨̌Ɉ͂܂ĕ炵ĂD
@ȂM҂́CgቷŉߗpꂽZx̊ɏՉthɂC[W悤ɁCߖOa͂߂ĕsȏԂłC킸ȕIȎhɂĂ܂CȌۂɂȂƎvĂD̂悤ȍlς̂gGRJChł<a href="#R32"><sup>32)</sup></a>i<a href="#F7">}7a</a>jDC^[lbǧ́C炪vȂƂ񓚂ĂDƂCgߖOahŌƁgGRJChԂĂD|_igẺߖOant𗘗pȈՃq[^[GRJCłD8 M̐|_igEߖOant͎ł͂߂ĈłC߂ȂƂŉߖOa͉ȂDƂ낪CߖOantɂ͋ЂĂCăJ`bƂՌƉߖOa͏uɉČ̐͏o͂܂D50 ml̐|_igEnt1ӏɐ́Cb̂ɓ`dđŜő̂ɂȂD̂Ƃ̋ÌŔM𗘗pĒgƂ邱Ƃł̂łD₦ăJ`J`Ɍł܂|_igE͕ŎςƗnDuƗ₦āC͂߂̉ߖOantɂǂD

<a name="F7"></a><div id="fig7-caption-text" style="display: none;"><strong>}7@GRJCƃr̚</strong>
iajő́ijւƕςĂr̃GRJCD
ibjr̚D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.7.jpg" target="_blank">[Download]</a></div>[hs_figure id=7&amp;image=/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.7.png&amp;caption=fig7-caption-text]

@|_igE͂܂܂ȉ̂ȂłƂɉߖOa`₷łCȂ̋ނƂĂ悭gĂ炵DM҂w⍂Z̎ƂŖڂɂƂ̂ȂDLɂȂ̂͋Ȃł낤DwĎۂɑ̌Ă݂Cg^pÑA~Chی`́CߖOaɂhƊmMDGRJCÒuĂCߖOa͂炭ivɉȂD܂CԂɂDꂪJ`bƂՌɂ萔bŌŉD邢́C|_igÊЂƂ킦Ƃ|_igE͂V[hƂČJnD܂ŁC؂Ƀ}b`ŉ΂邱ƂɂC܂ňɑ݂Ă؂ꂪuɔR؂Ă܂C[WłDߖOa͏dvłDĂȂƂł͂ȂDr̚₪voꂽi<a href="#F7">}7b</a>jDr̓̚f}[NEdger RubinƂl1900N͂߂ɍlĂłDł邪C̎ӂɒڂƌl̊Ɍg܂GhƂĂȂݐ[D܂ŁCA~Chۂ̍\ɒڂsĂDA~Chۂ̍\͏dvł邪C܂ňʂłCƓ邢͂ȏɏdvȂ͍̂\肾łDgnxhgߖOahɒڂ邱ƂKvłD

<h2>5DA~Chۂ̌`̐</h2>
@IȃA~Chۂ̌`́C͂UƂȂǂ̃AWe[V킦ĂԂ̂Č̈łDg̏Ǝ˂́C͂UƂɔ׌ʓIł邾łȂ삪ȒPłD܂CΏۂƂ^pNntꂽǂ𗁑ɂĒgƎ˂邱Ƃł̌ʂ݂邱ƂłDŁCA~Chۂ̌`钴gƁC̎xɑłv[g[_[̂邱Ƃl<a href="#R43"><sup>43)</sup></a>DA~Chۂ̌`̓`ItrŤupƃv[g[_[ɂʉ邱ƂłDۂɎŝĂ}CNv[gpĎsĂ݂ƒǧʂ͂ƌo邱Ƃłi<a href="#F8">}8</a>jDv[gŒ肵܂܂ł͏Ǝ˂钴g̋xGlM[͈قȂ邽߁Cv[g̈ʒuɂA~Chۂ̔܂ł̒xԂ͑傫قȂDŁCv[g]Ǝ˃GlM[ł邾ώƒxԂ͓D܂CA~Chۂ̌`͒g̏Ǝ˂ɂ董i镨włDȂCgƎ˂ȂƓԂŃA~Chۂ͂܂`ȂD

<a name="F8"></a><div id="fig8-caption-text" style="display: none;"><strong>}8@gɂA~Chۂ̌`</strong><a href="#R43"><sup>43)</sup></a>
iaj96EFv[gɃ<sub>2</sub>~NOu̗ntƃ`ItrT킦CgƎ˂D`ItrŤuxϑ邱ƂɂA~Chۂ̌`oDԂFŎEFł́CA~Chۂ葬`ĂD
ibjꂼ̃EFɂu̎ԕωD
icjꂽA~Chۂ̌qԗ͌D
idjHANABI̊OρD
iejHANABIpĊϑ<sub>2</sub>~NOũA~Chی`D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.8.jpg" target="_blank">[Download]</a></div>[hs_figure id=8&amp;image=/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.8.png&amp;caption=fig8-caption-text]

@gƎˑuƃv[g[_[Ƃ̂邱ƂɂCA~Chۂ̌`IɗUo鑕uHANABIJi<a href="#F8">}8</a>jĎꌹHANdai Amyloid Burst InduceriA~ChUujłD܂ŁCłグԉ΂悤ɁC̒xԂ̂̂A~Chۂ̌``ItrŤux͋}㏸DƂ΁C<sub>2</sub>~NOupfł́C1ԂɓăA~Chԉ΂Ăɑłグ邱ƂłD̑uHANABI͋zUȂǂ̌oł̂ŁCA~ChۂłȂg̏Ǝ˂ɂ邳܂܂Ȍۂ̊ϑɂpłDɂ́C^pÑlCeBuԂɂ錋CA~ChۈȊÕ^pN̋ÏW܂܂DƂɋ@\^pN̋ÏW͍R̈Ȃǃ^pN܂̈萫]邤ŏdvłCɊp邱Ƃ҂łD

<h2>6DߖOa̎̂ƒg̍p@\</h2>
@ߖOaƂ͂ł낤DԂƂ͉ł낤DȂϐ^pN̓A~ChۂƂĂɐ͏oߖOaԂɕۂ̂ł낤D܂Cg͂ǂ̂悤Ȃ݂ɂߖOâł낤DߖOaɂĂ˂ƁCg񕽍thgԁhȂǂ̗pƂƂɊj`̂ނDj`炷ݍp̓GlM[Iɂ͍D܂C̕qW邱Ƃ̓Ggs[IɍłC߂Ă܂ɂNȂDj`ƁĈ̂̐͗eՂłCj͈CɐĕtԂɂD̂悤Ȑ́C^pN܂ވʂ̌̕łȂCA~Chۂ̌`ɂĂ΂ΗpDȂCGRJC̋łȉߖOa݂ĂƁCǂĂȂɊj`ނ̂Cʂ̐قȂDȂ|_igE͋łȉߖOant̂Ĉ݂͂ǂ̂炢Ă̂낤D
@ɂqׂ悤ɁCߖOȃ\Iȗ͐̉ߗpłDXɂȂ邵݂͕ẘ{IdvȖł萸͓IȌȂĂ<a href="#R44"><sup>44)</sup></a>D2002NCX`̊jRs[^[ɂčČꂽ<a href="#R45"><sup>45)</sup></a>DX`̊jƂ́C̕X^̐flbg[NɌ`ꂽԂłC߂ĎRGlM[Č͍łDŋ߂ł́Cߗp̍\Ƃꂩi߂Ă<a href="#R46"><sup>46)</sup></a>Dߗpɂ́CU邢͐łȂƂł悢C\̍\Cꂪߗp̓قȕ炵ĂƂD܂Cߗp̍\ꎩ̂oNƈقȂĂ\D
@ȏ̐̉ߗpɊւc_݂ƁCߖOa̎̂͂܂ł<a href="#R32"><sup>32)</sup></a>DߖOa͌͏o̎RGlM[ǂƂɂ萶鏀ԂłDnɂƂ莩RGlM[ǂƂ͑ΓIȖłD1̉\́CʓIɂ悤ɁC͏ô߂̊j`̎RGlM[ǂƂłDC͏o炷q́Cɂ܂܂ȍ\]ڂU\Dꂪ͏oƋ锽łȂ΁C͗ntԂ̎RGlM[CЂẮCΓIɗn̐͏o܂āČʁCߖOaƂȂDʂ̂ƁCfbhGhv_Ng̈艻łD̂悤ȃfbhGhv_NgƂẮCnqɂnx߂悤ȍ\ω̂قCqԂł̏ȑݍpȂǂlDɏЉߗp̍\<a href="#R46"><sup>46)</sup></a>C܂ɂ̂悤ȏԂɂ݂DɑzƁC^pÑtH[fBO͕sn̕ϐ^pNn𐫂ĉߖOaɂȂ邱Ƃǋ߂ɐfbhGhv_Ngɂ݂Ă܂D
@ȂƂĂm肽͉̂ߖOa̎̂łDǐ̉ߗpЂɂƁCߗpۂɂ́Cj`̍łȂCXƋ悤Ȑ̍\̋NĂ\DGRJCɂ͐|_igĚƋ悤ȍ\|_igE̐nt\݂Ȃ낤DlCeBuȃjg]`[̉ߖOantɂ͌Ƌ悤ȗnt\Ȃ낤DA~Ch^pNyv`h̉ߖOantɂ̓A~Ch͏oƋnt\Ȃ낤DȂCM҂z悤ȃfbhGhv_NgƂẲߖOaԂ̎̂𖾂炩ɂ͂ȂD̎wWƂėnt̓`x肳邪CߖOaɂĂ̓m}[ȊÔ݂̂悤ɂ݂͂ȂDA~Ch̕ł͍זEŐIS}[̒~ςڂĂ邪CߖOaƃIS}[Ƃ̊֌WɂĂ悭킩ȂDCߖOai݂ƃKXԂDŁCKXԂƂ͉ߖOaԂ̂܂܃gbvꂽ̂Ƃ݂ȂƂłDKXԂĂ˂ɒׂ邱ƂłCߖOa̎̂𖾂炩ɂ肪肪炦邩ȂD
@܂CߖOaԂɑ΂钴g̍p̕q@\𗝉邱Ƃ[łD݁ClߖOả炷@\ƂāCgLre[VCA̕\ʂɃ^pNZks`ÏWЂNĂ\i<a href="#F4">}4</a>jDs`ÏWɃA~Chj킸ł܂܂Ă΁CjƂĉߖOa͉A~Ch͐͏oD}ōlƁi<a href="#F6">}6b</a>jCgƎ˂ɂC̈ƕs̈C邢́Cs̈ƃKẌƂ̋EɈړƍlDɂĂCǧʂ͋͂łA~Chۂ̌̋͂ȎiƂȂ邱Ƃ͂܂ȂD

<h2>7DߖOaȊẘJ</h2>
@܂ŁCM҂́CA~Chۂɋ̍\`ĂDu⌴qԗ͌ɂA~Chۂ̌`Ԃ𒲂ׁČq\ѕq\̉𖾂߂Ă<a href="#R23"><sup>23-26)</sup></a>DāCaIݍp␅f̏dvC܂CV[hɈˑ`̓𖾂炩ɂĂD̂悤ȍ\wIȌdvł邱Ƃ͋^ȂD
@Cr̚i<a href="#F7">}7b</a>jɏے悤ɁCA~Chۂł闝Rt̎_l邱ƂdvłD܂CɗnĂ^pNyv`h͗nx̒ቺł͐͏oDƂ낪Cۂɂ͗eՂɐ͏ołȂƂ΂΂łCߖOaԂĂ܂DāCߖOâȂłԂ͈ӊOɂłłCʏ̏ł͉ȂDꂪ̂́CȂ炩̌ɂǏIȔZxɍ܂CԂێłsԂ邢̓KXԂꍇłDߖOaԂ̈萫Ƃ͊֌WȂCV[hꂽꍇɂ͉ߖOa͈CɉD
@̂悤Ȏ_ɂƁC1ɏdvȂ̂́Cn̔ZxƗՊEZxƂ̊֌WłD^pNɂƂ肻̍\ƔZx̑}<a href="#R41"><sup>41,47)</sup></a>i<a href="#F9">}9</a>jDnł^pN͗nxD^pN傫ĂĂnx荂ZxɂĂ͕qԑݍp܂^pN͐͏oDlCeBuȃ^pN̗nx͍̂ɑ΂C^pN͕ϐƗnx͋ɒ[ɉ̂ŁCϐ̓^pN̐͏oЂND̂ƂC^pN̍\j[NłX͂ɗp悤ȒP`DCϐ^pN̂悤ɍ\lł΁Cnx^pN͕s`ȋÏŴ`DCϐ^pNł߂ĒZyv`h͌`DA~Ch^pN؂oꂽc̃yv`h͔`邪C̓A~ChƂăA~Chۂ̃fƍlĂ<a href="#R19"><sup>19,22)</sup></a>D炭Cʂ̃A~Chۂ͒Pƕs`ȋÏŴƂ̂ɈʒuDۂ̂̋KIȑݍpłP͂łȂDłCNX\͈ێ邱ƂɂA~ChۂłD^pNȂ葊ݍpɑlɂȂƁCKIȃNX\Ƃ邱Ƃłs`ȋÏŴDāC}ɂ͉ߖOaԂDnxĂߖOa݂邱ƂɂC]ڂ͂ɂ͋NȂDԂsԂ݂̑͐͏oۂ𕡎GDɐ͏o̗͂܂ƉߖOa͈ێłKXԂoD炭Cs`ÏW邢̓KXԂ̌`ɉߖOa݂͑Ȃ<a href="#R41"><sup>41)</sup></a>D

<a name="F9"></a><div id="fig9-caption-text" style="display: none;"><strong>}9@^pN̗nxƍ\</strong><a href="#R41"><sup>41,47)</sup></a>
iaj^pÑTCYƔZxɈˑ\Ԃ̑}D
ibjRtH[Ṽj[NƔZxɈˑ\Ԃ̑}D
nx̋E͔M͊wIɌ肳Ă邪C݂̗nx͉ߖOaɂxzĂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.9.jpg" target="_blank">[Download]</a></div>[hs_figure id=9&amp;image=/wordpress/wp-content/uploads/2013/01/Goto-2.e002-Fig.9.png&amp;caption=fig9-caption-text]

@ȂCnxɂƂÂA~Chی`̃f́Cb_̗ՊE~ZZxƃ~Z`ɂ悭ĂDCIɈقȂ̂́Cb_̃~Z`ɂ͉ߖOa݂͑ȂƂł낤DߖOa͌̂悤ɂƂKIȍ\ɂ̂ݑ݂ƍlD܂CKIȒɂ͉ߖOa邪Cs`ÏWɂ͂ȂC邢́C߂ĕsłƗ\D
@ȏ́gnxhgߖOahɂƂÂƁCA~Chۂ̕q\ьq\ɂƂÂƂ̂ɂȂƂCr̓̚䂪𖾂ł낤D

<h2></h2>
@^pN╨̉ߖOaۂɒڂƐȊw̐VȒn݂Ăi<a href="#F1">}1</a>jDɂqׂ悤ɁCJCXɂ炸CƖ̂̂̂܂ɂ͕KߖOaDREňʓIȉߖOa͐̂ɂ[肱݁C^pNُ̈ȋÏW⌋΂łȂCۑŜɑ傫ȉeyڂĂ\DCߖOaLłƂ琶͉ߖOapł낤CsłȂΐ͂ł邾邩ŐiĂł낤DA~Chۂ̌`͐ߖOa𗘗p\IȗƂ݂ȂƂłDߖOaȂΗnx^pNyv`h͂ɐ͏oDƂ낪CߖOaɂntԂ͈ێD́C}Ȋ̕ωɑ΂ɏՍp炷qVŷ͂炫ɎĂD
@̂قĈɂă^pN̂ߖOaۂƂāCAN`ǂȂǑ@ۏ̍\̂̌`ȂǂlDɂ͂܂܂ȃ^pN֗^̌`╪𐧌䂵ĂDECX̑BɂẮCECXj_JvVȟ`̓JvVh^pNPʑ̂j_ꂽ̂CɐisD̏ꍇɂCJvVh^pNPʑ̂̉ߖOâĂ\DߖOaۂ̓͑傫ȋłDGRJC킩悤ɁC߂Ă͂肵ĂĈ̃XCb`ƂčœKłD
@܂Ń^pN̍\@\ČCЂẮCȊw̌ŜɂāCgߖOahƂTO͂قƂǒڂĂȂDCRE݂킽ƁCߖOa͂߂ĂӂꂽۂłDāCwHwɂ镨̗̈̕悩Cntwɂ鐅̉ߗp̌̈Cwɂ錋΂̌̈܂ŁCߖOaOƂLsĂDłCߖOaׂ̎̂͂Ă̌̈ɂĂ܂łDߖOa͉Ȋŵ܂܂ȗ̈f{IՓIŖ{IȊTOłDVȐ؂Ƃ邱ƂɂCȊw̔IȐiW҂łD

<h2> </h2>
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</ol>

<h2>Ql}</h2>
<ol>
<span class='au'>㓡S</span>: <span class="ti">^pÑtH[fBOƃA~Chی`F^pNC̊Ɩ̊.</span> <span class='so'>w, 21, 898-902 (2003)</span>
</ol>
<ol>
<span class='au'>Lee, Y. -H. & Goto, Y.</span>: <span class="ti">Kinetic intermediates of amyloid fibrillation studied by hydrogen exchange methods with nuclear magnetic resonance.</span> <span class='so'>Biochim. Biophys. Acta, 1824, 1307-1323 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22885025" target="_blank">PubMed</a>]</span></li>
</ol>
<div class="au-profile">
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<span class="author">㓡 SiYuji Gotoj</span>
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URLF<a href="http://www.protein.osaka-u.ac.jp/physical/yoeki.html" target="_blank">http://www.protein.osaka-u.ac.jp/physical/yoeki.html</a>
</div>
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