Ɖu}BזEF䐫BזE

<strong>n `T</strong>
iwƉuwteBAZ^[ 䌤j
emailF<a href="mailto:babay@ifrec.osaka-u.ac.jp">n`T</a>
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̈Zr[, <strong>5</strong>, e002 (2016)@<a href="http://dx.doi.org/10.7875/leading.author.5.e002">DOI: 10.7875/leading.author.5.e002</a>
Yoshihiro Baba: <strong>B cells with suppressive function in immune reaction: regulatory B cells.</strong>

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<h2>v </h2>
@BזE͍R̂YtƉuɂĒSIȖ͂ƂChɂȂĂ͂ȂȂpłD܂CȖƉuCǁCAM[ɂĂ͔ǂaԂ̈Ɋ֗^邱ƂLmĂDCƉu𘴐ipƂ͋tɁCƉu}BזȆ݂CBזÊVȋ@\ƂĒڂĂDBזE͐䐫BזEƂ΂Cŋ߂̌̐iWɂ肻̐̂Xɖ炩ɂĂD̃r[ɂẮC䐫BזE̐ƖƉu̗}̋@\CāCaԂւ̊֗^ɂāCŋ߂̒m܂D

<h2>͂߂</h2>
@2015NBזE̔炿傤50NDR̂Y郊pƂē肳ꂽƂ킩悤ɁCBזE͉tƉuɂĒSIȖ͂D܂CTזEɑ΂R̒񎦂TCgJC̕ɂƉu𐧌䂷邱ƂBזȄdvȖڂłD̂͂炫ɂCBזE͕â̊ɑ΂̖ḧꗃSŁCȖƉuCǁCAM[̌ƂȂaԂ肷邱ƂmĂDCƂ͋tɁCƉu}BזEƂĐ䐫BזȆ݂炩ɂ꒍ڂĂ<a href="#R1"><sup>1)</sup></a>DƂɁCRǐ̃TCgJCłC^[CL10Y鐧䐫BזÉC܂܂Ȏf}EXpCǂ⎩ȖƉuCɂ́CƉuᇖƉuȂǂɑ΂}\ƎC̐̑Ώۂ͑lł邱Ƃ炩ɂĂi<a href="#F1">}1</a>jDɁCC^[CL10ȊŐ@ɂƉu}鐧䐫BזȆ݂񍐂Č͔̈WDƉu̗}\BזE̐Vȋ@\Ƃďdvł΂łȂCƂ̊֘AĂՏẘϓ_ڂD̃r[ɂẮC䐫BזĚ̂܂ł̓WJѓW]ɂĉD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@䐫BזEɂ}Ɖuю</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/01/Baba-5.e002-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2016/01/Baba-5.e002-Fig.1.png&amp;caption=fig1-caption-text]


<h2>1D䐫BזE̐󂨂уTuZbg</h2>
@ŏBזEɂƉu̗}ꂽ̂́C1974ÑbggڐG畆Ɋւ񍐂ł<a href="#R2"><sup>2)</sup></a>DBזËړɂa󂪊邱ƂꂽCBזEBזËړł͂̍p݂͂ȂD}EXɂŏ̕񍐂͎IȖƉu]Ґfł<a href="#R3"><sup>3)</sup></a>DBזE`IɌ}EXł͖쐶^̃}EXɔ׎IȖƉu]Ґ̕aԂ邵ĎCBזEƉuɑ΂}Iɂ͂炭̂ł͂Ȃƍl悤ɂȂD2000NɂȂƁCׂĂBזEƉu̗}\𔭊킯ł͂ȂCC^[CL10YBזEƉu}\ƂCg䐫BזEhƂ΂悤ɂȂD̂̌̐iWɂC䐫BזE̗}Ώۂ͑ɂ킽邱ƂD݂ł́C咰CIȖƉu]ҐCR[QU֐߉CڐG畆CAM[CI^AaCڐAБΏhaC얞ɂ閝ǂƂߏȖƉuɂ鎾aCƉuюᇖƉu}ƍlĂ<a href="#R4"><sup>4-10)</sup></a>i<a href="#F1">}1</a>jD
@C^[CL10䐫BזEɂƉu̗}ɏdvłƂ񍐂𔭒[ɁCǂBזẼTuZbg䐫BזEȂ̂Ƃۑɑ΂EMĒ킵ĂʁC̐̂Xɂڂɂꂽ<a href="#R11"><sup>11)</sup></a>i<a href="#F2">}2</a>jD͂߂ɕ񍐂ꂽ̂́CCD1dBזEłD咰fɂāCC^[CL10YCD1dBזEԖp߂ɂđǂ}邱Ƃꂽ<a href="#R4"><sup>4)</sup></a>D̂̂CBT2ӉBOזEiIgMCD21CD23jR[QU֐߉ɂ<a href="#R12"><sup>12)</sup></a>C܂CB10זEiCD5zCD1dBזEjڐG畆ɂ<a href="#R13"><sup>13)</sup></a>CC^[CL10YBזEł邱Ƃ񍐂ꂽDBזEɂ͂ƂɕӉBזEƂ̏d݂ꂽDɁCB10זEB1זEƂ\^ɎĂDȑOCB1זEC^[CL10𕪔傷邱Ƃ͒mĂCB2זEƋʂ邽߂̎wWƂĎgꂽقǂłDVeB1זEזE̋@\}ǐTזE̕jQ邱ƂꂽCaԂƂ̊֌W͖𖾂łD܂CI^^pNłTIM1̔ƃC^[CL10̎YƂɑւ̂邱Ƃꂽ<a href="#R1"><sup>1)</sup></a>DBזEɂC^[CL10̎YɂẮCBזE<em>in vitro</em>ɂĎĥELISA@邢͍זETCgJCF@ɂ]ꂽDC|[^[}EXp<em>in vivo</em>ɂC^[CL10̔ɂĒׂƁCTlۂɊ}EXɂĂB̃vY}זE<a href="#R14"><sup>14)</sup></a>CIȖƉu]ҐɂĂ͏p߂̃vY}uXg<a href="#R15"><sup>15)</sup></a> ɂČoꂽD܂łɕ̌ñC^[CL10|[^[}EX쐻Ă邪Cꂼ̌nɂĊxmRNÄ萫قȂ邽߉߂ɂ͒ӂKvł̂́C𔭏ǂ}EXɂăC^[CL10YBזE𓯒肷LȎiɂȂƎvD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@䐫BזE̗̕U</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/01/Baba-5.e002-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2016/01/Baba-5.e002-Fig.2.png&amp;caption=fig2-caption-text]

@䐫BזE̕\ʃ^pN̕\^ɊւẮC̕񍐂ɂ炸ʂĂƂ͂D̗RƂāCɗpĂ鎾fCC^[CL10Y̕]nCƉu̈ႢeĂ\D܂C䐫BזẼTuZbgłƂ͂ȂDɁCC^[CL10ȊO̗vfɂƉu̗}\𔭊BזEɂĂ̒m~ςDBזEƂ܂CƂ΁Cǂ⊴ȂǈقȂhCCǍ݂̈ႢɂC܂܂ȕ邢͊̉ߒւ䐫BזẼTuZbg݂lĂ\lD

<h2>2D䐫BזEƎȖƉu</h2>
@ȖƉufɂBזEɂƉu̗}ɂĂ͑̕񍐂邪Cł́CrI͂̐ił֐߉є]ҐɂďqׂD
@}EXII^R[QƉu邱Ƃɂ蔭ǂ邱Ƃ̂łR[QU֐߉̓qg̖֐߃E}`̎fƂĎg邱ƂD֐߃E}`̓R[Qɑ΂鎩ȍR̂ɂ蔭ǂ邽BזE͕aqƂĂ͂炭CBזE}qƂĂp邱Ƃ񍐂ꂽDR[QU֐߉𔭏ǂ}EXɂāCBT2ӉBOזEvȃC^[CL10YBזEł邱Ƃꂽ<a href="#R12"><sup>12)</sup></a>D̃TuZbg<em>in vitro</em>ɂăR[Q̎hɂC^[CL10𕪔債Cʂ̃}EXɈړ邱Ƃɂ֐߉̏Ǐɘa邱ƂmFꂽD̗}\͋CłɊ֐߉𔭏ǂĂ}EXɂĂʂ݂ꂽDɁCnBזȆBшێCvY}זE̐ɂďdvȖ͂TCgJCłBAFF݂̑̂ƂŔ|{BזEړƁCC^[CL10ɈˑăR[QU֐߉̏Ǐ}邱Ƃ񍐂ꂽ<a href="#R16"><sup>16)</sup></a>DqgɂĂC֐߃E}`̊҂ɂĂ̓C^[CL10Y\BזE̐Ă邱Ƃ񍐂ĂCaƂ̈ʊ֌WɊ֐S悹Ă<a href="#R17"><sup>17)</sup></a>D
@IȖƉu]Ґ̓}EXɐ_o̐\^pNł鎩ȍRуAWogƉu邱Ƃɂ蔭ǂ邱ƂłC̏Ǐ̗ގqg̑dǂ̃fƂčLgĂDIȖƉu]Ґ𔭏ǂ}EXɂāCRCD20R̂̓^ɂBזEƏǏ͉P邪Cǂ̂܂BזEƋtɕaԂ͏dǉ邱Ƃꂽ<a href="#R18"><sup>18)</sup></a>D܂CBזE͔ǂ̂Ƃяɂ͖Ɖu̗}Cǂ̂̂ɂ͖ƉȗiDʂɂȂ邱ƂꂽDBBזE̗{qړɂIȖƉu]Ґ͗}C̍pɃC^[CL10̎YK{ł邱Ƃꂽ<a href="#R5"><sup>5,13)</sup></a>DM҂́C|[^[}EXpɂC<em>in vivo</em>ɂăC^[CL10𔭌ĂBזẼTuZbg͏p߂ɂĕ̗UvY}uXgł邱Ƃo<a href="#R15"><sup>15)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/9615" target="_blank">V_r[</a> łfځjDvY}uXgBזEvY}זEւ̏̒̕iK̍זEłƍlĂCvY}זEƓlɍR̂̎Y\CvY}זEƈقȂ葝B\]ʈqBlimp1̔ႢDBOȓIɐ؏}EXɂĂ͎IȖƉu]Ґ̕aԂɕωȂƁCp߂BזE݂Ȃ}EXɂĂ͎IȖƉu]ҐƂCBזEƉu̗}\𔭊ꏊ͏p߂łCC^[CL10zvY}uXg}BזEł邱Ƃ\zꂽDہCvY}זE̕ɕK{łBlimp1BזEɂēٓIɌ}EXɂĂ͎IȖƉu]Ґ̑F߂ꂽ<a href="#R15"><sup>15)</sup></a>Dp߂̃C^[CL10YvY}uXg͎̕IȖƉu]Ґ̔ǂɂ͂߂ėU邽߁Cߏȉǂ}邽߂̃̕tB[hobN@\ƂĂ͂炢Ă\lD
@܂CC^[CL10ȊOɂƉu̗}@\񍐂ĂDRǐTCgJCłC^[CL35YvY}זEIȖƉu]Ґ̗}Ɋ֗^邱Ƃ炩ɂꂽ<a href="#R19"><sup>19)</sup></a>DC^[CL35YBזÉCIȖƉu]Ґ̂قɂCIȖƉuuhEɑ΂}pF߂ꂽ<a href="#R20"><sup>20)</sup></a>Ďnł́CC^[CL35̓C^[CL10YBזE̗̕UɕKvł邱Ƃ񏥂ĂDɁCPD-L1BזEhEwp[TזE}邱ƂɂIȖƉu]Ґ̕aԂ邱Ƃꂽ<a href="#R21"><sup>21)</sup></a>D̓C^[CL10ɈˑCɁC̃TuZbg͍RCD20R̂ɂĂȂD
@ÂCqg̑dǂBזE̊֗^邱ƂĂ<a href="#R17"><sup>17)</sup></a>DĔ^dǂ̗ՏɂāCRCD20R̂̓^ɂBזȄɂaς̒ጸї\̉P݂ꂽƂCaԂ̑ւBזE̊֗^ꂽ<a href="#R22"><sup>22)</sup></a>DtɁCaԂ̉PɊ֗^BזE̖ꂽDƂ΁Cdǂ̊҂ɗRBזE̓C^[CL10̎Y\ቺĂC܂Cdǂ̍Ĕ\hƂčŔFĂC^[tF̎hɂCBזEɂC^[CL10̎Yꂽ<a href="#R23"><sup>23)</sup></a>DɁCBAFFAPRILjQ銈̂A^VZvg̗Տɂđdǂ̍Ĕ̕px㏸DR͖炩ɂĂȂCBAFFC^[CL10YBזE̕UƂ񍐂邱Ƃ<a href="#R24"><sup>24)</sup></a>C䐫BזȄɂe֗^\D

<h2>3D䐫BזEƎ</h2>
@ᇖƉuɑ΂BזE}ʂƂ́CBזE}EXɂāCזEQTזE̍RᇊƁC񃏃N`̌ʂƂȂǂ玦ĂDBזE}EXł́C쐶^̃}EXɔׁC܂܂ȂזȆB}邪CɂBזEYC^[CL10̊^̑傫Ƃ񍐂ꂽ<a href="#R25"><sup>25)</sup></a>D܂C}EXBp𓊗^Ƃ̑BɂvƂȂ邪CRCD20R̂̓^ɂBזEƃp̑B͗}ꐶ啝ɉP<a href="#R26"><sup>26)</sup></a>D̎nɂāCCD5zCD1dBזEړƃpB悤ɂȂv㏸DC^[CL10BזËړł͂̌ʂ݂͂ȂƂCBזE̓C^[CL10ɈˑIɎᇖƉu}ƍlD܂Cᇂ̏p߂ɂBזEWς邱Ƃm邪CBזE}EXɈړƎᇂDᇍRɓٓIBזEזEƉu}邱ƂɂCזȆBɗLȊ肾ĂƎvꂽDm[}̏ꍇC̏p߂ɂBT2ӉBOזẼTuZbgpxɌoꂽ<a href="#R27"><sup>27)</sup></a>D
@ŋ߁COBɐZC^[CL10Y鐧䐫BזE̐VTuZbg肳ꂽD̃TuZbg̓vY}uXg̈ꕔƍlCƉuOuAzCPD-L1zCC^[CL10zƂ<a href="#R28"><sup>28)</sup></a>D}EXOB񃂃fɍR܂łILTv`pʂœ^Ăʂ݂͂ȂCBזE}EXRCD20R̂ɂBזE}EXɂẮCpʂ̃ILTv`ɂזEQTזE̊񂪔rꂽDILTv`̓^ɂC^[CL10zPD-L1zƉuOuAzBזẼTuZbgDʂɂזEւƐZCRᇖƉu}邱ƂꂽD̎ᇖƉu̗}ɂ̓C^[CL10CPD-L1CƉuOuÂׂĂ̔Kvł邱ƂꂽD܂C񃂃fł͏p߂ɂTGFYCD25zBזE̕UᇖƉu}邱Ƃ񍐂ꂽ<a href="#R29"><sup>29)</sup></a>ĎʂCᇖƉȗړIƂBזȄÖ@VȂ̎Ð헪ƂẲ\Ђ߂邱ƂlD

<h2>4D䐫BזEƊ</h2>
@BזȄdvȖ͊ǂɑ΂鐶̖hłDɁC̊Ɖu}悤Ȑ䐫BזE݂D׋ۂ̊ƂāCTlۂ邢̓XeAۂ̃}EXւ̊fɂĎꂽDBזE̓Tlۂr悤ȖƉuU邪C̍p@͍R̂ɂ̂ł͂ȂCR̒񎦂ɂTזEɂזEƉuU邱ƂɂƍlĂDŁCBזETlۂɑ΂銴h}邱ƂꂽDTlۂɊ}EXBɂĂ̓C^[CL10YvY}זE邢̓vY}uXg̕UꂽD<em>in vitro</em>ɂTlۂ̎hɂĂBזE̓C^[CL10𕪔債DBזEɂăC^[CL10}EXɂẮCTlۂɊƂ̍DCi`L[זECTזE̊CTlۂ̔r\邵㏸邱ƂꂽDɁCvY}זE邢̓vY}uXgɂ̓C^[CL35YTuZbg݂CTlۂ̊ɑ΂銴󐫂㏸Ă邱Ƃ炩ɂꂽD܂CBזE}EX̓XeAۂ̊ɑ΂RƂCXeAۂ̊ɂĂBזE͖Ɖu}ĂD̏ꍇCB̕ӉBזEC^[CL10̋ƂȂ}\𔭊邱ƂꂽD
@񐶒̊ɂĂBזE͘iї}𐧌䂷D񐶒̊ɂƂȂ݂BזEɂƉu̐ɂAM[⎩ȖƉȕǏ󂪊ɘa邱Ƃ񍐂ꂽDƂ΁CZz̊ɂAM[Cǂ}邪ČʂBɑ݂CD1dBזEɂC^[CL10̎YɈˑ<a href="#R30"><sup>30)</sup></a>DC񐶒Ɋ}EX̔xɂĂ䐫BזE̕UꂽCC^[CL10ȊŐ@\ɂ艊ǂ}Ă悤łD܂CǊ񐶐}EX̒Ԗp߂PCD23BזÉC{qړɂAM[Cǎxє]Ґ}C̍pC^[CL10ɈˑȂƂꂽ<a href="#R31"><sup>31)</sup></a>DBזE݂ꏊɂƉu̗}pقȂ\C@̉𖾂҂D
@qgɂĂ񐶒̊Ɛ䐫BזEƂ̊֘AĂDdǂ̊҂ɂĂBזEɂC^[CL10̎Y̒ႢƂmĂ邪C񐶒݂̊̂銳҂͊ĂȂ҂ɔׁCBזEɂC^[CL10̎YCߏȎȖƉu}Xɂ<a href="#R32"><sup>32)</sup></a>DߔNC킪܂ސiɂĂ̓AM[⎩ȖƉuĂČ̂ЂƂƂāCq̉PɂƂȂXN̒ቺ񏥂ĂD̋@͕sł邪C䐫BזE֗^\D
@ECX̊ɂ萧䐫BזE̕U邱Ƃ́C}EXTCgKECXpɂmFꂽDECX̊ɂC^[CL10YBזEуvY}uXgoCECXɓٓICD8zTזE̎Y}ꂽ<a href="#R33"><sup>33)</sup></a>D}EXK}wyXECX68̓}EXɌo@BזEɂĐ邱ƂmCECXɗRM2^pN͂̊̐эĊɂďdvƍlĂDāCĊɂM2^pNBזEɂ]ʈqIRF4̔𑣐iCvY}זE̕уC^[CL10̎YU邱Ƃꂽ<a href="#R34"><sup>34)</sup></a>Dh̖Ɖu}邱̍ṕC}EXK}wyXECX68̎TCN̐̂ߗLɂ͂炢ĂƑzꂽDqg̊ǂɂẮCqgƉusSECX<a href="#R35"><sup>35)</sup></a> 邢B^̉ECX<a href="#R36"><sup>36)</sup></a> Ɋ҂ɗR閖BזE̓C^[CL10̎Y\Ăƕ񍐂C䐫BזEƂ̊֘AwEĂD̕aƂ̈ʊ֌W͂܂sĂł邪C䐫BזEWIɂn͖ECX̊ɑ΂鐶̖h̋ƂėL]ȂD

<h2>5D䐫BזEɂC^[CL10̎Y̋@</h2>
@_ł́C䐫BזEɂƉu̗}\̒j̓C^[CL10łƍlĂDC^[CL10͂܂܂ȍזE番傳鋭͂ȍRǐTCgJCłC̎Y@\̌d˂ĂDBזEɂẮCTollléiToll-like receptorFTLRjCCD40CBזEễVOiKvƍlĂ<a href="#R37"><sup>37)</sup></a>D
@TLR2TLR4̎hBזEɂC^[CL10̎Yɏdvł邱Ƃꂽ<a href="#R38"><sup>38)</sup></a>DBזEł̂TLR2TLR4L}EXɂĎIȖƉu]Ґ̕aԂ邵ƂCTolllê<em>in vivo</em>ɂƉu̗}\ɂdvłD܂CTLR2TLR4̉^pNłMyD88BזEɂēٓIɌ}EXɂĂIȖƉu]Ґ݂̑CTolllễVOȉdvmFꂽDɁCTlۂ̊fɂĂCTLR2TLR4MyD88ւVOiBזEɂC^[CL10̎YуTlۂɑ΂Ɖuコ<a href="#R14"><sup>14)</sup></a>DTolllễVOiBזẼvY}זEւ̕ND̍ہCIRF4Blimp1̔K{ƂȂƂCTolllê̎h̓C^[CL10Y鐧䐫vY}uXg̕ɕKvłƑzꂽDBlimp1mbNAEg}EXɂ킦CIRF4BזEɂĂ̓C^[CL10̎YQĂCM҂̌ɂCBזEɓٓIIFR4mbNAEg}EXɂĂ͎IȖƉu]Ґ̏Ǐ󂪏dǉ邱Ƃ炩ɂꂽ<a href="#R15"><sup>15)</sup></a>DɁCIRF4͕łȂCC^[CL10`q̓]ʂɂ֗^邱Ƃꂽ<a href="#R15"><sup>15,34)</sup></a>D
@BזE̕\ʂɔCD40́CTזE̕\ʂCD154ƌ邱Ƃɂ芈ČʁCBזȆBѕUDTזEɈˑƉuɕK{̉ߒł邪C䐫BזE̋@\ɂĂdvłƍlĂDBזEɓٓICD40L}EXł͎IȖƉu]ҐdǉC̕aԂBזEɂC^[CL10̎Y\̒ቺɂ邱Ƃ񍐂ꂽ<a href="#R5"><sup>5)</sup></a>DR[QU֐߉fɂĂCCD40hBזE̓C^[CL10̎Y\iC̍זEړ邱Ƃɂ֐߉}邱Ƃꂽ<a href="#R12"><sup>12)</sup></a>D
@BזEê͍RɓٓIBזẺɂĕK{łDIȖƉu]Ґ𔭏ǂ}EXPBזEiȍRFBזE܂܂jʂ̃}EXɈړƎIȖƉu]Ґ}邱Ƃł邪CƉuĂȂ}EXPBזEł̗͂}ʂ͔Ɏォ<a href="#R39"><sup>39)</sup></a>D܂CR̔FŒ肵BזEéiȍRɂ͔ȂjBזE͎IȖƉu]Ґ}łȂDɁCIȖƉu]ҐЂN}EXPBזEBזEêhƃC^[CL10傳ꂽ<a href="#R5"><sup>5)</sup></a>ĎʂC䐫BזE̖Ɖu̗}\ɂ͍RِKvł邱ƂꂽD
@M҂̌CBזEểɂăC^[CL10̎YɏdvȂ̂Ca<sup>2+</sup>VOił邱Ƃ炩ɂꂽ<a href="#R40"><sup>40)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/2800" target="_blank">V_r[</a> łfځjDBזEêhƁCꂽzXzp[[C2CmVg[1,4,5-gX_YCꂪE̖ɂCmVg[gX_êƌ邱Ƃɂ菬ÊɒꂽCa<sup>2+</sup>זE֕oDÊCa<sup>2+</sup>̗V͋}ɋN邪ʂߐłCזEɂCa<sup>2+</sup>Zẍێɂ͍זEOCa<sup>2+</sup>̎IȗKvłDSTIM͏E̓oɂCa<sup>2+</sup>̌mƁCזEɂCa<sup>2+</sup>`lƑݍpCa<sup>2+</sup>D̉ߒ̓XgA쓮Ca<sup>2+</sup>Ƃ΂<a href="#R41"><sup>41)</sup></a>DBזEɓٓISTIM}EXɂĂ̓XgA쓮Ca<sup>2+</sup>jQ邪Cɂ킦CC^[CL10̕傪邵ቺDCa<sup>2+</sup>ɂ芈ꂽJVj[ѓ]ʈqNFATC^[CL10̔Uƍlꂽ<a href="#R40"><sup>40)</sup></a>i<a href="#F3">}3</a>jDBזEɂSTIMٓIɌ}EXɂĂ͎IȖƉu]ҐC̃}EXɗRBזEɂĂ̓C^[CL10̎YjQĂƂCCa<sup>2+</sup>̗BזEɂƉu̗}\ɏdvł邱Ƃ킩<a href="#R40"><sup>40)</sup></a>D

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@䐫BזEɂC^[CL10̎Y̋@\</strong>
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<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/01/Baba-5.e002-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2016/01/Baba-5.e002-Fig.3.png&amp;caption=fig3-caption-text]

@CD40VOiCTolllẽVOiCBזEẽVOi̓C^[CL10̎Yɂďdvł邪CȈӖł́C䐫BזE̕ɕKvȂ̂C邢́CC^[CL10`q̓]ʂɕKvȂ̂C킩ĂȂDȊOɂCC^[CL21ê邢MHCNXIIqBזEIȖƉu]Ґɑ΂}\ƂmĂ邪<a href="#R42"><sup>42)</sup></a>Cׂ͂ăvY}זE̕ɕK{ł邱ƂC܂𖾂ĂȂ䐫BזE̋̕@\𗝉肪ɂȂƊ҂D

<h2></h2>
@BזE͖Ɖȗiї}̓ʐƂC̍p̃oX⑊݂̃tB[hobN@\̔j]a̕aԂɊ֗^邱ƂD̃r[łƂ肠قɂCqgɂăC^[CL10Y镡BזẼTuZbg肳Ă<a href="#R15"><sup>15,23,43)</sup></a>C}EXɂmƂ킹Ɛ䐫BזE͋ψȃTuZbgȂƂ͍lɂĈƂ͌i߂邤ł̏ǂ̂ЂƂƂȂĂD̓_ɂĂC䐫TזEɂFoxP3̂悤Ȑ䐫BזEɂēٓIȈ`qC邢́CʂėpVOî݂ǂ͂肳邱ƂdvƍlD}BזE푽lłꍇɂ́CƂɐC@\CqՂ𖾂炩ɂĂƂK{ł낤D̂ŁCqgɂĐ䐫BזEƎ̕aԂƂ̈ʊ֌W𖾂炩ɂCBזE̋@\WIƂՏpւƓWJ邱Ƃ҂D

<h2> </h2>
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</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">n `TiYoshihiro Babaj</span>
F2002N ww@wnȔmے CCN čOklahoma Medical Research FoundationmC2005N wƉuAM[ȊwZ^[ oāC2008NwƉuwteBAZ^[ CyD
</div>
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