f^̐EFǎê̕

<strong>M ʉ</strong>
ic`mww wj
emailF<a href="mailto:myuzaki@a5.keio.jp">Mʉ</a>
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̈Zr[, <strong>3</strong>, e003 (2014)@<a href="http://dx.doi.org/10.7875/leading.author.3.e003">DOI: 10.7875/leading.author.3.e003</a>
Michisuke Yuzaki: <strong>Delta receptors: a tale of an orphan receptor.</strong>

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<h2>v </h2>
@Mނ̒_onɂ~bPʂ́gh̐_o`B́CVivXOoO^~_ƁCVivX㕔ɂĎeCI`l^O^~_êɂSDf^^ếCCI`l^O^~_ê̈ƂāC1993NɑXN[jOɂ肻̈`qN[jOꂽDCf^^ê̓O^~_Ƃ͌CCI`lƂĂ̊ołȂD̂߁CNɂ킽gǎéhƂĂDCf^^ê}EX̉͂Cf^^ê]̋@\ɕK{ł邱Ƃ͖młDāCf^^êǂ̂悤ɋ@\̂ɂĂ͒N̓łD20NނC悤₭Se炩ɂȂĂf^^ê̗̌jTD

<h2>͂߂</h2>
@CI`l^O^~_êɂ́C܂ւ̔CAMPA^CNMDA^CJCj_^݂ƐwIɍlĂD1989NAMPA^O^~_eGluA1R[h`qŏɃN[jOĂ2`3N̂ɁCcAMPA^éiGluA2`GluA4jCNMDA^éiGluN1CGluN2A`GluN2DjCJCj_^éiGluK1`GluK5jR[h`qƃN[jOꂽDqẅЗ͂ƂƂɁCۂςݏグĂẅ̑傳ĔFłDf^^eGluD1GluD2R[h`q͂̃S[hbVxC1993NɊm̃CI`l^O^~_êƂ̑XN[jOɂN[jOꂽ<a href="#R1"><sup>1-3)</sup></a>DGluD1GluD2̓A~m_z񂩂͖炩ɃCI`l^O^~_êɑDCO^~_͂ߌ郊Kh͂킩炸CCI`lƂĂ̊słƂCƁgǎéhiorphan receptorjƂĂDGluD2}EX͒ȏ]Ǐ<a href="#R4"><sup>4,5)</sup></a>D܂CGluD1}EXɂ͍g̒oQ݂<a href="#R6"><sup>6)</sup></a>D̂悤ɁCǎêłȂCGluD1GluD2͒_onɂďdvȋ@\͂Ƃ炩łDC̋@\ǂ̂悤ɐ䂳Ă̂ɂẮCNɂ킽̂܂܎cĂD
@GluD1GluD2̌ɂ͓{l҂傫^ĂĎʁC悤₭GluD1GluD2̃KhуVOi`B@\炩ɂȂĂD܂CߔNł́Cǂ邢͍@\QGluD1邢GluD2̈`qɐψقƂ̊֌WwE悤ɂȂCGluD1GluD2̃VOi`B@\̗́C]݂̂ł͂ȂC_onɂʓIȃVivX@\̉𖾂ɂȂ̂Ɗ҂ĂDlIɂ́Cf^^ê̈`qN[jOꂽ1993N͕M҂w@mےCNłCMҎgČƂĂ̌ǎễVOi`B̉𖾂̗jƌ闧ɂD𖾂ȓ_͐cĂ邪C20N܂̐l̑ƂāC܂ł̃f^^ê̌jƍ̓W]ɂĂ܂Ƃ߂D

<h2>1Dkψك}EX炩ɂGluD2̌ÓTIȋ@\</h2>
@vLGזE͏]玿炻̊OւƗB̏o͂𑗂_oזEłDvLGזÉCˋN̉ʕזE̕sہCˋN̋߈ʕɉI[uj̓oۂ́C2ނ̋̓͂D1̃vLGזE10`20{̕sۂƃVivX`ŁC1{̓oۂƂVivX`ȂDvLGזE͕sۂɂ17`150 Hz̕pxŔ΂iPXpCNjCoۂ̓͂ł1`2 Hz΂ȂiGXpCNjDCЂƂѓoۂ̓͂ɂ蔭΂ƁCvLGזEɂCa<sup>2+</sup>Zx̑傫ȏ㏸ЂNĎʁCoۂƕsۂɓ͂邱ƂԂƕs-vLGזEVivXɂVivX`B̌Ԃɂ킽ቺĎۂ𒷊}iLTDFlong-term depressionjƂԁD̔]ɒ~Lɂ͂܂܂Ȏނ݂邪CZ\^Ɋ֗^Ľ`ɂ͏]dvȖ͂DL̊bƂȂߒ́CVivXɂ_o`B̌̒IȕωłƍlĂD]ɂ^wK̊bƂȂߒ́Cs-vLGזEVivXɂ钷}łCoۂ̓͂̃^C~OgtMhƂĕs-vLGזEVivXɂ钷}̗U𐧌䂷ƂwK_iMarr-Albus-Ito_jmĂ<a href="#R7"><sup>7)</sup></a>D
@GluD2͕s-vLGזEVivXɂăvLGזÊˋN̞ˋNɂقڑIIɔDGluD2R[h`q́Cق̃O^~_ê̈`qi190 kbjƔׂ߂đ傫i1.4 MbjD܂CF̐Ǝ㕔ʂɈʒu邱ƂCŕψقND̂Ckijψق}EX<em>hotfoot</em>}EXƂсC܂ŏȂƂ16ނ̓Ɨ<em>hotfoot</em>ψق񍐂Ă<a href="#R8"><sup>8)</sup></a>DlHIɍ쐻`qmbNAEg}EX܂߁CGluD2}EXł͕s-vLGזEVivX̐ȃ}EX60炢܂Ō<a href="#R5"><sup>5,9)</sup></a>ĎʁCGluD2}EXł̓vLGזE̎ˋNɃVivXO݂Ȃg̞͂ˋNhώ@DX̏Ǝ˂ɂזE̐ѕsۂ̓͂ቺۂɂĈ悤Ȃ̞͂ˋN͈ꎞIɊώ@DC̏ꍇɂ́C͎csۂƃVivX`DGluD2}EX̞̓͂͂ˋNđ݂邱ƂłCGluD2͕s-vLGזEVivX̌`ɏdvłƗ\zꂽDۂɁCGluD2}EX̃vLGזEɃECXxN^[ɂGluD2𔭌ƁCs-vLGזEVivX͐̂ɋ}Ɍ`<a href="#R10"><sup>10)</sup></a>D܂Cqgَ̐tɗRזEłHEK293זEGluD2𔭌זEƋ|{ƁCHEK293זÊɕs-vLGזEVivXُIɌ`ꂽ<a href="#R11"><sup>11)</sup></a>DC}EX̂ɂȂĂGluD2ƁCłɌ`Ăs-vLGזEVivX͂ɂ͂C̞͂ˋNo<a href="#R12"><sup>12)</sup></a>ĎʂCGluD2<em>in vitro</em><em>in vivo</em>ɂĕs-vLGזEVivX̌`шێ𐧌䂷@\Ƃ킩D
@GluD2}EXł͓o-vLGזEVivXɂُ킪݂D쐶^̃}EXɂăvLGזE͗c᎞ɂ͕{̓oۂƃVivX`C͐nƂƂ1{̓oۂcĊ荞܂DCGluD2}EX̃vLGזE͐n̂ɂ{̓oۂƃVivX`gc^h<a href="#R5"><sup>5,9)</sup></a>D̂悤ȗc^̓oۂɂxźCsۂƃvLGזEƂ̂̃VivX`Bቺ}EXCƂ΁Cӌ^O^~_ê}EXCa<sup>2+</sup>`l}EXɂĂώ@<a href="#R13"><sup>13)</sup></a>DāC̕\^GluD2̌ɂ蕽s-vLGזEVivX邱ƂɂC2IȌʂłƍlD܂C쐶^}EXł͓o-vLGזEVivX̓vLGזE̎ˋN̋߈ʕɌǂČ`邪CGluD2}EXł͋߈ʕɂ킦ʕ̎ˋNɂ܂œo-vLGזEVivX`<a href="#R14"><sup>14)</sup></a>ĎۂCs-vLGזEVivX߁Cʕ̎ˋNɂ܂œoۂił悤ɂȂƍl邱ƂłD2̓͂_oזEɂāC̓͐ۂƂ̃VivXƁCЂƂ̓͐ۂ̃VivX̂̈΂ۂ́Cق̔]ʂɂĂώ@邩łD̂悤ɁCGluD2}EXɂĊώ@o-vLGזEVivẌُ́Cs-vLGזEVivX̌ɂ2IȌۂƂĐ\łD
@[ƂɁCcs-vLGזEVivX͌`ԓIɂ͐ł̂́CVivXYƂĒ}ЂNƂłC@\Iɂ͐ł͂Ȃ<a href="#R4"><sup>4)</sup></a>D}N邽߂ɂ͕sۂ̓͂Ɠoۂ̓͂KvłDCGluD2}EXɂ钷}̗ȔQ́Csۂ邢͓oۂƃvLGזEƂ̃VivX̌`ُɂ킯ł͂ȂƂD܂CGluD2ɑ΂R̂vLGזEɓ^ƒ}ЂN邱Ƃ킩<a href="#R15"><sup>15)</sup></a>D܂CGluD2́Cs-vLGזEVivX`@\ɂ킦Ci`ԓIɊjs-vLGזEVivXɂăVivXY̒}𐧌䂷Ƃ@\Ăi<a href="#F1">}1</a>jDł́Ĉ悤GluD22̋@\́Cǂ̂悤ȕq@\ɂŜ낤H

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@GluD2}EX̕\^</strong>
GluD2̃kψك}EX́C̃xł͕sC^̏QC^wK̏Q݂D_oH̃xł́C1js-vLGזEVivX̐Ă̞͂ˋNoC2jc镽s-vLGזEVivXɂăVivXY̒}QCƂ2̕\^D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/03/Yuzaki-3.e003-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2014/03/Yuzaki-3.e003-Fig.1.png&amp;caption=fig1-caption-text]


<h2>2DǎeGluD2̃VOi`B@\T鎎</h2>
@ʂɁCKhsȌǎễVOi`B@\𖾂邱Ƃ͍łDtɁCVOi`B@\킩Ȃ߁C@\XN[jO@ɂ郊Kh̓s\łDŁCM҂́C܂܂ȕʂɕψق킦GluD2GluD2}EX̃vLGזEɔCs-vLGזEVivX̌`sSƒ}̏QƂ2̎vȕ\^񕜂邩ǂgXL[hsƂɂC̋@\Ɋ֗^GluD2̋@\hCi荞ނƂX^[g<a href="#R16"><sup>16)</sup></a>D̂߁CvLGזEɂĂ܂܂ȕψGluD2ٓIɔgXWFjbN}EX쐻GluD2}EXƌzD܂CECXxN^[pGluD2}EX̃vLGזEɂ܂܂ȕψGluD2𔭌邱ƂsD̃Av[`ɂ݂邩ȂC@\hCi荞ނƂǎeGluD2̃VOi`B@\T邤ł͋ߓł낤ƍl̂łD
@GluD2͂ق̃CI`l^O^~_êƓl̍\ƂƍlDזEON[hCƃKhhCCזE̓ɃCI`l|AhCCāCזEC[hCi<a href="#F2">}2</a>jD낢ƂɁCN[hCψGluD2GluD2}EXɔƁC}̏Q͉񕜂̂́Cs-vLGזEVivX̒`͉񕜂Ȃ<a href="#R17"><sup>17)</sup></a>DtɁCC[hC4A~m_cψGluD2GluD2}EXɔƁCs-vLGזEVivX̒`͉񕜂Co-vLGזEVivẌُ퉻̂́C}̏Q͉񕜂Ȃ<a href="#R10"><sup>10,18,19)</sup></a>DCKhhC<a href="#R20"><sup>20)</sup></a> `l|AhC<a href="#R21"><sup>21)</sup></a> ɕψق𓱓GluD2GluD2}EXɔĂCs-vLGזEVivX̒`ђ}̏Q͂Ƃɉ񕜂ĎʂCGluD2̂2̎vȋ@\̔ɂ́CKhƂ̌CI`lƂĂ̋@\͕svł邱ƂD܂CGluD2̍N[hCC[hĆCꂼCs-vLGזEVivX̌`ђ}̗UƂ2̋@\ʌɐ䂷邱Ƃ̂ł<a href="#R22"><sup>22)</sup></a>i<a href="#F2">}2</a>jDtɁCN[hCC[hC΁CKhhC`l|AhC͕svł邱Ƃ<a href="#R23"><sup>23)</sup></a>DɂĂCGluD2̓CI`l^O^~_êɑɂ炸CCI`lƂĂO^~_̎êƂĂ@\ȂƂCȂϑIȃ^pNłDǂŁC̃VOi`B@\ȂȂ킩Ȃ킯łD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@GluD2̃hC\Ƃꂼ̃hC̕ψقɂe\^</strong>
GluD2́CזEOCN[hCCKhhCC`l|AhCCC[hCDTM1`TM4͂ꂼꖌђʕʂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/03/Yuzaki-3.e003-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2014/03/Yuzaki-3.e003-Fig.2.png&amp;caption=fig2-caption-text]


<h2>3DGluD2̍N[hCVivX̌`𐧌䂷VOi̎</h2>
@CGluD2͍N[hCĂǂ̂悤ɕs-vLGזEVivX̌`𐧌䂵Ă̂낤H@̓́C܂\zO̕炫D_炢ƁCזE番傳Cbln1Ƃ܂ŃCI`l^O^~_êƂ͂܂֌WƍlĂ^pNCs-vLGזEVivX̑Oɑ݂NeurexinƁCVivX㕔ɑ݂GluD2̍N[hCƂɓɌ邱ƂɂCs-vLGזEVivX̌`шێ𐧌䂷̂łDM҂炪C̔ɂo܂ȒPɏЉD
@1984Nɏ]ɓٓIȃyv`hƂcerebellin肳ꂽ<a href="#R24"><sup>24)</sup></a>D1991NcerebellinR[hprecerebellin mRNA肳ꂽ<a href="#R25"><sup>25)</sup></a>DCprecerebellin mRNAR[hA~m_zɂ̓yv`h̑ÔƂẴ`[t݂͑CSƂĎRƉun̕C1qƗގ^pNR[hĂD̂߁Cprecerebellincerebellin̑Ôł͂ȂCꎩ̂@\̂ł͂ȂƍlCgprehƂړ͕sKł邱Ƃ̂Cbln1Ƃ΂邱ƂɂȂi<a href="#F3">}3</a>jDCbln1זEɂقڑIIɔC̃kψك}EXזE̐Ɍyx̒ቺi10j݂ƂƂɉ^D̂ƂCCbln1זE̐ێ^pNłƍlꂽDCق̕\^݂͂炸CCbln1̎êVOi`B@\͈ˑRƂĕsłD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@Cbln1̃hC\</strong>
iajRƉun̕C1qDN[CCysCR[QlhCCC1qhCDC1qhC͎Oʑ̂̍\ƂCɉ18ʑ̂`D
ibjCbln1Dcerebellin̑ÔƍlprecerebellinƖꂽCbln1hC\ƂC2̎Oʑ̂ĘZʑ̂`D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/03/Yuzaki-3.e003-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2014/03/Yuzaki-3.e003-Fig.3.png&amp;caption=fig3-caption-text]

@2002NɂȂCM҂̌Cbln1}EX͈̉˗܂ꂽDقǂȂCdCwIȉ͂ɂCCbln1}EX͕s-vLGזEVivX̐ቺCC}ЂNȂƂ<a href="#R26"><sup>26)</sup></a>D̂ƂCCbln1͕s-vLGזEVivXɂċ@\邱Ƃ^ꂽDŁCs-vLGזEVivXdqɂڍׂɉ͂ĂƂCVivX̐̌IȒቺƃvLGזEɂ̞͂ˋN̏oƂCGluD2}EXƍ\^ƂD܂CCbln1זE番傳邱Ƃ킩D̂悤ɁCꂼ̌}EX̕\^邱ƂCêsCbln1ƃKhsGluD2́C݂ɕ̂`̂ł͂ȂƍlɂD̂̂CGluD2̍N[hCCbln1ٓIɌ邱Ƃ<em>in vitro</em>ɂ薾炩ɂ邱ƂɐD܂CƉugDFɂCs-vLGזEVivX̃VivXԌɂCbln1Ǎ݂CGluD2}EXł̓VivXԌCbln1邱Ƃ킩<a href="#R27"><sup>27)</sup></a>DCbln1}EXCbln1𓊗^ƕs-vLGזEVivX̂Ɍ`ꂽ<a href="#R28"><sup>28)</sup></a>CCbln1GluD2Ƃ̓d}EXłCbln1̓^ɂVivX̌`݂͂Ȃ<a href="#R27"><sup>27)</sup></a>D̎́Csۂ番傳ꂽCbln1vLGזEGluD2ƌ邱ƂɂCs-vLGזEVivX̌`шێ𐧌䂵ĂƂDقǂȂCCbln1̓VivX㕔ɑ݂GluD2ƓɁCVivXOɑ݂NeurexinƂ邱Ƃ<a href="#R29"><sup>29)</sup></a>DGluD2̃VOi`B@\𒲂ׂĂM҂̌Cbln1}EX̉͂˗ꂽ̂͂܂̋RłC܂Cbln1Nɂ킽TĂGluD2̃KhłƂ́Cgtoo good to believehƂׂZfBseBȔłD
@̌i߂邤ŏdvȔ̂ЂƂ́CGluD2plHVivX̌`ł<a href="#R11"><sup>11)</sup></a>DזEƐtɗR_oזEłHEK293זEƂ|{ĂCזE̎HEK293זEɂ̓VivXO`ȂDCGluD2𔭌HEK293זEɂ͐lHVivX`̂łDM҂́CCbln1}EXזEGluD2𔭌HEK293זEɂ͐lHVivX`ȂCCbln1|nɂ킦邱ƂɂlHVivX̌`U邱ƂoDȂ킿CCbln1זE̓ɂčp̂ł͂ȂCזEOɕ傳ꂽCbln1VivX̌`U邱ƂmɂȂDxāCGluD2𔭌HEK293זEזEƂ̂ɐlHVivX`CGluD2ƂƂɖƉu~Ă^pNʕ͖@ɂ͂ʁCGluD2CCbln1CNeurexinȂ^pN̂`邱ƂCM҂̌Ƃ͂܂Ɨĕ񍐂ꂽ<a href="#R30"><sup>30)</sup></a>D2010NɂȂCGluD2͌ǎêł͂ȂCbln1̎êƂĂ̈ʒum̂łi<a href="#F4">}4</a>jD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@GluD2͂͂ǎêł͂Ȃ</strong>
GluD2́CsۂoN[hCɌCbln1ƁCcȂƂɃOAזEoꃊKhhCɌD-ZƂC2̃KhDC[hC͒}̗Uɋ@\D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/03/Yuzaki-3.e003-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2014/03/Yuzaki-3.e003-Fig.4.png&amp;caption=fig4-caption-text]

@GluD2-Cbln1-Neurexin̂͂܂łɒmĂVivX`^pNƂ͈قȂ2̓ĂDЂƂ́CVivX̌`Ԃ␔̂̂ɍp_łDƂ΁CNeurexin}EXNeuroligin}EXł̓VivX̐ɑ傫Ȓቺ݂͂ꂸCVivX̌`Ƃ̓VivX̐nɍpƍlĂDGluD2-Cbln1-Neurexin̂VivXOɂăVivXEWςCVivX㕔ɂGluD2C[hCɌ^pNWς邱ƂɂVivX̐nɊ^Dɂ킦āCGluD2-Cbln1-Neurexin͕̂s-vLGזEVivX̑OˋNU{^̍\`p邱Ƃ킩<a href="#R31"><sup>31)</sup></a>DNeuroliginNeurexinƌ邪Ĉ悤Ȋ͂ȂD̈Ⴂ́CGluD2ƌCbln1NeuroliginNeurexinxɏWς邱Ƃɂ̂ƍlĂDVivX`^pNƂĂGluD2-Cbln1-Neurexin̂̂ЂƂ̑傫ȓ́Cn̂ɂăVivX`銈ƂłDɏqׂ悤ɁCCbln1}EX̏]Cbln1𓊗^ƕs-vLGזEVivX̂Ɍ`Dق̃VivX`^pNɂ<em>in vivo</em>̐n]ɂ銈͂ȂCĂɎアD

<h2>4DGluD2C[hCVivXY𐧌䂷VOi̎</h2>
@GluD2C[hCĂǂ̂悤ɕs-vLGזEVivXɂVivXY𐧌䂷̂낤H@CI`l^O^~_ê̂ЂƂAMPA^ê_oɂăVivX㕔ɂđIIɃGhTCg[VX邱ƂC}̕q̂łƍlĂD܂ł̌Cs-vLGזEVivXɂāC}Uh͑ӌ^O^~_êC̉ɂveCLi[[CCAMPA^eGluA2TujbgC[ɑ݂880ԖڂSer_邱Ƃ킩ĂDGluA2Tujbg͂C[ŌW^pNGRIPƌ邱ƂɂVivX㕔ɂȂƂ߂Ă邪C880ԖڂSer_邱ƂɂGRIP͂Cʂ̌W^pNPICK1ƌ邱Ƃɂ蒷}<a href="#R32"><sup>32)</sup></a>i<a href="#F5">}5</a>jDƂ΁CsۂƓoۂƂ𓯎ɎhɁC]̐ؕЂɃz{[GXe𓊗^ăveCLi[[C𒼐ڂɊ邱ƂɂĂCs-vLGזEVivXɂĒ}U邱Ƃł<a href="#R33"><sup>33)</sup></a>D낢ƂɁCGluD2}EX̏]̐ؕЂɃz{[GXe𓊗^ĂGluA2Tujbg880ԖڂSer̓_ꂸCGRIP͂Ȃߒ}͗UȂƂ킩<a href="#R34"><sup>34)</sup></a>DɁCGluA2Tujbg880ԖڂSer4cO876ԖڂɂTyrCGluD2}EXł͒ԂɂĂTyr̃_iĂ邱ƂDGluA2TujbgC[̒fЂp<em>in vitro</em>ɂ郊_ł́C876ԖڂTyr_ĂƁC炭dׂ邢͗̓IȏQɂC880ԖڂSer̃_jQꂽD܂CGluD2}EX̏]̐ؕЂł͒}Uh킦ĂGluA2Tujbg880ԖڂSer̓_ꂸCAMPA^ễGhTCg[VXi܂C}j͋NȂDC܏ɂGluA2Tujbg876ԖڂTyrE_ƁCGluD2}EXɂĂ}Uhɂ880ԖڂSer_悤ɂȂC}񕜂D܂C876ԖڂTyrPheɒu_Ȃ悤ɂGluA2TujbgvLGזEɔGluD2}EXł́C}ɗUꂽDȏ̌ʂ́CAMPA^eGluA2Tujbg876ԖڂTyr̃_̘iCGluD2}EXɂ钷}̏Q̌ł邱ƂĂi<a href="#F5">}5</a>jD

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@GluD2͒}́gN₷h𐧌䂷Ԃł</strong>
iaj쐶^̃}EXɂẮCGluD2C[hCɃ`VzXz^[[PTPMEG邱ƂɂCAMPA^eGluA2Tujbg876ԖڂTyr̃_͒ቺDGluD2}EX̃vLGזEɂẮC876ԖڂTyr̃_͘iĂD
ibj}Uhɂӌ^O^~_êhƁCveCLi[[CCAMPA^eGluA2Tujbg880ԖڂSer_D̂߁CAMPA^êW^pNłGRIP͂CAMPA^ễGhTCg[VXi܂C}jЂNDGluD2}EXł876ԖڂTyr̃_iĂ邽߁CveCLi[[C880ԖڂSer_łCGRIPAMPA^ê͂ȂD̂߁C}͏QD
PKCFveCLi[[CCY876F876ԖڂTyrCS880F880ԖڂSerCPF_D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/03/Yuzaki-3.e003-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2014/03/Yuzaki-3.e003-Fig.5.png&amp;caption=fig5-caption-text]

@ł́CGluD2}EXł͂ǂAMPA^eGluA2Tujbg876ԖڂTyr̃_iĂ̂낤H@M҂́CTyr̃_Ɋ֗^CCvLGזEɔGluD2ƌ^pNƂāCPTPMEGɒڂDPTPMEG̓oh4.1hCPDZhCזE^`VzXt@^[[ŁC2000Nɍyc[nCubh@ɂGluD2C[hCɌ^pNƂē肳ꂽ<a href="#R35"><sup>35)</sup></a>DPTPMEG}EX̏]ł͒}Q邪<a href="#R36"><sup>36)</sup></a>C̕q@\͂悭킩ĂȂDM҂́CGluA2Tujbg876ԖڂTyrPTPMEG̊ƂĒE_邱Ƃ𔭌DۂɁCPTPMEG}EXł876ԖڂTyr̃_iĂČʁC}Uhɂ880ԖڂSer̓_ȂDɏqׂ悤ɁCC[hC4A~m_cψGluD2GluD2}EXɔĂ}̏Q͉񕜂ȂDC4A~m_cψGluD2PTPMEG̃`VzXz^[[hC𒼐ڂɗZLGluD2GluD2}EXɔƒ}񕜂D܂CzXt@^[[ȂψPTPMEG쐶^}EX̏]vLGזEɔƁCPTPMEG̋@\jQ}QꂽDCzXt@^[[ȂPTPMEGɂɕψق𓱓GluD2ƌłȂψPTPMEǴCPTPMEG̋@\jQ}QȂDȏ̎ʂCGluD2C[hC}̐ɂ́CPTPMEGƂ̌Ƃ̃zXt@^[[Kv\ł邱Ƃ炩ɂȂ<a href="#R34"><sup>34)</sup></a>DGluD2C[hCPTPMEGƌ邱ƂɂAMPA^eGluA2Tujbg876ԖڂTyr̃_̏Ԃ𐧌䂵Cg}̋N₷h𐧌䂷Ԃ̂悤Ȗ͂Ăƍl<a href="#R37"><sup>37)</sup></a>i<a href="#F5">}5</a>jD
@2007NGluD2̃KhhČ\CD-ZуOVƌ邱Ƃɂ藧̍\ω邱Ƃꂽ<a href="#R38"><sup>38)</sup></a>DC̐IȈӋ`͕słDM҂́CD-ZvLGזEɓ^ƁCs-vLGזEVivXAMPA^êGhTCg[VX邱Ƃo<a href="#R39"><sup>39)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/2665" target="_blank">V_r[</a> łfځjDGluD2}EX̃vLGזEC邢́CD-ZƂ̌ʂɕψق𓱓GluD2𔭌vLGזEɂĂ͂̌ۂ݂͂ȂD܂CזE̊ɂ蕽sۂoꂽO^~_BergmannOAɑ݂Ca<sup>2+</sup>ߌ^AMPA^êɌƁCBergmannOACa<sup>2+</sup>D-Zo邱ƂoꂽDނ̏]ɂĂD-Zyf̔ʂ2`3T荂Ȃ邽߁CD-Z̕o͗ĉ݂ɂ݂D2`3T܂ł͒}U₷^wKl₷̂́CBergmannOAoD-ZGluD2̃KhhCƂ̌AMPA^ễGhTCg[VXi܂C}jЂN₷邽߂ł邱ƂDD-ZƂ̌ɂAMPA^ễGhTCg[VX̐ɂCGluD2C[hC͕K{łD̂ƂCGluD2̃KhhCD-Z邱ƂɂЂNȂ炩̗̍\̕ωCזEɓ`dCC[hCɌPTPMEGAMPA^ễGhTCg[VX𐧌䂷oH쓮邱Ƃli<a href="#F4">}4</a>jD

<h2>5D{ɂǂāFGluD2̓CI`lƂĂ͂炩Ȃ̂H</h2>
@̂悤ɁCGluD2͍N[hCɌCbln1ɂ蕽s-vLGזEVivX̌`шێ𐧌䂵CKhhCɌD-ZC[hCɌPTPMEGɂAMPA^ễGhTCg[VXȂ킿}𐧌䂷邱Ƃ킩DdvȂƂ́Ĉ̋@\GluD2̃CI`lƂĂ̊KvƂȂƂłDł́CGluD2̓CI`lƂĂ܂@\Ȃ̂ł낤H@CI`lƂċ@\ȂƂƁCCI`l^O^~_ê̈Ƃă`l|AhC̃A~m_z񂪐iIɕۑĂ邱Ƃ܂łȂDۂɁCRGluD2̈`qψك}EXł<em>lurcher</em>}EXł́CKhhCƃ`l|AhCƂ̂̃J[1A~m_ψقɂCGluD2˂ɊJCI`lƂċ@\邱Ƃ킩Ă<a href="#R40"><sup>40,41)</sup></a>D܂CCI`l^O^~_êłJCj_^ê邢AMPA^ễ`l|AhCGluD1邢GluD2̃`l|AhCƒuLếCO^~_̓^ɂJCI`l<a href="#R42"><sup>42)</sup></a>DȂ킿CGluD1GluD2̃`l|AhĆC񐶗Iȏł͂̂́C`lƂċ@\邱Ƃ\łD
@ŋ߂ɂȂCӌ^O^~_emGluR1邱ƂɂCIȏɂĂGluD2CI`lCԌo߂̒xVivXdЂNƂꂽ<a href="#R43"><sup>43)</sup></a>D܂CGluD2mGluR1veCLi[[Cƕ̂`ĂCGluD2}EXłmGluR1̃VOi`Bቺ邽ߒxVivXdシ邱Ƃꂽ<a href="#R44"><sup>44)</sup></a>DC܂łmGluR1ۂɂ݂xVivXdTRPC3`lʉ߂CIɂ邱ƂĂCTRPC3}EXł͂̓d͂܂<a href="#R45"><sup>45)</sup></a>D̂Ƃ́CGluD2̓CI`lƂċ@\̂ł͂ȂƂD܂CxVivXd͍זEɂ`Ṽ_iƌシ邱ƂmĂCۂɁCGluD2}EXɃ`V_̑jQ܂𓊗^ƁCサĂxVivXd͐퉻D̂ƂCGluD2}EXɂĊώ@xVivXď́CPTPMEG̊̏Qɂ`V_̘iɂƉ߂邱ƂłD̂悤ɁCGluD2CI`lƂĂ͂炭̂C͂炭Ƃ΁Cǂȏꍇłǂ̂悤ȐIȈӋ`̂ɂẮCɎcꂽۑłD

<h2>6Df^^êƍ̔]@\Ƃ̊֌WF]Ɠ</h2>
@ߔNCGluD2̌ψقƌnŕ񍐂ꂽ<a href="#R46"><sup>46-48)</sup></a>D̊҂́CGluD2}EXɂ\^ƓlɁC]̉^⎩U咥ƂDC2̗\zO̒m炳ꂽDЂƂ́Cqgł͏]̈ޏk͂Ȃ͂_łD}EXł͏]̒ł͖쐶^12قǂޏk݂͂ȂCqgł͏]̒80`96߂̗eς݂̌DʂɁCזE̐̂߂ɂ̓vLGזE-sۃVivXts̉h{qKvƂĂDqg̃vLGזE̓}EXƔ1זE͂邩ɑ̕sۂƃVivX`ĂD̂߁CGluD2ɂ镽s-vLGזEVivX̌זEɑ΂Ă傫ȉeڂ̂ȂDЂƂ̓IȒḿCꔭB̏QłD͏]̍\Qł͂ȂC@\̏QƍlĂD5Ύ̏Ǘł2ꕶbȂC12Ύ̏Ǘł3Ύɑ錾̗͂Ȃ肷<a href="#R47"><sup>47)</sup></a>D̍]@\̏Q͏]̔^̋@\𔽉fĂ̂C邢́C]ȊO̔]ʂɔĂGluD2̋@\𔽉fĂ̂ɂẮČۑƂȂĂDqgGluD2R[h`q́C}EXƓlɁCɑ傫F̐Ǝ㕔ʂɑ݂ĂDāCCGluD2̕ψقɂ򐫈`ƌnVK̕ψقɂ銳҂邱Ƃ\zD
@GluD1̓}EXł͓̓LэזEɂċDcɂ͐̂ɋ邪Cn̂ɂ͂ɊCnɂĎアF߂ƂĂ<a href="#R2"><sup>2)</sup></a>DۂɁCGluD1}EXɂ͍g̒oQ݂邪CCnɂVivXY͏QȂƕ񍐂Ă<a href="#R6"><sup>6)</sup></a>DƂ낪ߔNCGluD1R[h`qƐ_Ƃ̊֘AŎwEꂽDƂ΁CQmCh֘A͂ɂoɐQ<a href="#R49"><sup>49,50)</sup></a> 邢͓<a href="#R51"><sup>51-54)</sup></a>CɁCRs[^͂ɂ莩ǂƂ̊֘A񍐂ĂDŁCGluD1}EX̕\^𐸍ƂC}EXɂĂsǏU̘iCǏCЉ̏Q݂邱Ƃ񍐂ꂽ<a href="#R55"><sup>55)</sup></a>D<em>in vitro</em>ł̎ɂāCGluD1̍N[hCɂCbln1₻̃t@~[^pNłCbln2邢Cbln4CVivX`\<a href="#R27"><sup>27,56,57)</sup></a>D܂CA~m_z񂩂GluD1C[hCɂPTPMEG邱Ƃ\zĂCۂɁĈɂPTPMEGĂ<a href="#R35"><sup>35)</sup></a>D̂ƂCGluD1GluD2ƎVOi`BoHđO]ɂċ@\C]@\Ɋ֗^邱Ƃ\zĂD<em>in vivo</em>ɂGluD1ǂ̂悤ɍp̂Cꂩ̌̐iW҂D

<h2></h2>
@`qN[jOCʕ͖@CɋߔNł́CQm͂ɂC܂ł܂܂Ȗm̃^pN肳ĂDC肳ꂽ^pN̋@\̉𖾂͕KȒPł͂ȂD̃r[ł́CXN[jOɂ`qN[jOĈȗ20N߂̎ւāC悤₭VOi`BoḦ[炩ɂȂĂgǎéhf^^êɂĂ̌jLDēƒfƉcꂸUԂĂ݂ƁČ̐iWɂāC2̑傫ȃuCNX[ƎvDЂƂ́CXL[ɂGluD2̋@\hC̍i荞݂̐łDGluD2̍N[hCC[hCꂼʁX̋@\ɕKv\ł邱Ƃ킩Ă͂߂āC̃XebvɏW邱Ƃ\ɂȂDXL[̓VEWEoGɂĂ͕ʂɍsĂC܂݂ł́C`qψك}EX̍쐻CECXxN^[ɂٓIɈ`q𔭌邱Ƃ́CقǂւȂƂł͂ȂDC10N܂̎_ł́C}EX̕\^wWƂXL[̎{ɂƂ肩ɂ͑傫ȌfKvƂD̂悤ȌóCʂ߂΂łȂCƍČ邱Ƃ̑؂炽߂ĎDЂƂ́C܂C傫ȃuCNX[́CCbln1}EXƂ̏ołD܂ZfBseBȔłCGluD2}EX̕\^mĂ炱CCbln1GluD2̃Khł͂ȂƋ^ƂłDǂ̂ƂCm̃^pÑVOi`BoH̉𖾂́CF҂C肱ƌi߂邱ƂȂ̂ȂD

<h2> </h2>
<ol>
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</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">M ʉiMichisuke Yuzakij</span>
F1993N ȑww@mے CCN čRoche Institute of Molecular BiologyC1995N čSt. Jude Childrenfs Research HospitalC2002N  yoāC2003Nc`mww D
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URLF<a href="http://www.yuzaki-lab.org/" target="_blank">http://www.yuzaki-lab.org/</a>
</div>
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