F̂̐ڒُƂ

<strong>OIiEn粉ÓT</strong>
iwqזEw F̓Ԍj
emailF<a href="mailto:ytanno@gmail.com">OIi</a>C<a href="mailto:ywatanab@iam.u-tokyo.ac.jp">n粉ÓT</a>
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̈Zr[, <strong>1</strong>, e004 (2012)@<a href=" http://dx.doi.org/10.7875/leading.author.1.e004">DOI: 10.7875/leading.author.1.e004</a>
Yuji Tanno & Yoshinori Watanabe: <strong>Sister chromatid cohesion defects and cancer.</strong>

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<h2>v </h2>
@זEɂĕF̂𐳊mɕz邱Ƃ́C̂̔␶̎ւ̌pɂƂK{łDُȕzɂ萶F̐̉ߕśC`̊l炷ƍlĂD̂זEł͐F̕s萫Ƃ΂鍂px̐F̂̕zُ킪ώ@C̐זÊ񉻂₪̈𑣐iƍlĂDF̂SɂĕۂɃRq[VƂ΂^pNɂڒCMɂăRq[V𗣂邱Ƃɂ蕪DߔNC̐F̂̐ڒ̐@\ɂĂ̗}ɐi݁CF̂̕s萫ւƂȂoHɂĂm[܂Dł́CF̂̐ڒɂ鐧ُ킪CזEɍL݂F̂̕zُЂNq@\ɂĉD

<h2>͂߂ɁFF̂̕zُƂ</h2>
@F̂̕zُ͑̂זEɂċʂɂ݂鐫̂ЂƂłD̐́gF̕s萫hichromosomal instabilityFCINjƂ΂CF̕s萫זE͐F̂̐茸肷gِhDِ́C`q̃Rs[̑₪}`q̃Rs[̌CזÊ񉻂т̈̈ɂȂƍlĂDזEɂِ́C܂1Iȏ܂Ɋώ@CזÊ񉻂ɂdvȃXebvɂȂƂTÔ납񏥂Ă<a href="#R1"><sup>1,2)</sup></a>D̂̂CF̕s萫̂ЂN錴͓ɂ܂ĂCߔNɂȂCqxł̒m}ɒ~ς̗͐iWĂ<a href="#R3"><sup>3)</sup></a>DזEɂF̂̕z@\̔j]͐F̕s萫ЂNƂdȌƂȂƍlĂDʓIȃqg|{זEɂזE͖24Ԃł邪ĈCזE􂨂ѐF̂̕zɗv鎞Ԃ͂ق1Ԃɂ݂ȂD̒ZԂ̂ȂŃ_Ci~bNmɕzF̂̂ӂ܂𐧌䂷镪q@\͔ɐōIłDzׂoF̂́C邻̏uԂ܂Ō݂ɐڒăyA`ĂC̃yǍ`ϓȐF̂̕zۏႷ錮ƂȂ镪q@\łD܂ŁC̐ڒ̐@\ƐF̕s萫эזÊ񉻂Ƃ̊֘A͂܂蒍ڂĂȂCߔN̔|{זEѓ̂pʂ̒~ςɂCF̂̐ڒ@\̔j]F̕s萫ЂNƂōזÊ񉻂𑣐iƂfĂꂽDł́CϓȐF̂̕zۏႷ镪q@\ɂĉƂƂɁCoF̂̐ڒ@\̔j]ǂƓ̂Ƃ̐ڑ̌ĐF̕s萫̈ƂȂƂfɂĉD
@ȂCF̕s萫́Cׂ͐F̂̐̕s萫inumerical chromosomal instabilityjƁCF̂̍\̕s萫istructural chromosomal instabilityC`q̈̌dȂǁjƂɕ邪Cł́CO҂F̕s萫ƂďqׂD

<h2>1DF̃TCN</h2>
@זE􂷂邱ƂőBTCNiזEj悤ɁCF̂ɂ{ƕzƂTCNiF̃TCNji<a href="#F1">}1</a>jDG1ɂ1Zbg̐F́iqg̏ꍇɂ́C46{jSiDNAjɔ{D̂ƂCꂽoF݂̂͌ɐڒăyA`D̂̂CG2ւMijɓƁCF͕̂zɓKRpNgȂɋÏki<a href="#F2">}2</a>jD̂ƂCזEƐF̂ƂuĂĂj͕󂵁CF̂̉^щłXshǂF̂Ƃ炦ߒɓDזE̗̋ɂLтĂXshǂ́CoF̂̂ꂼɌ`铮̂ɔ΂̕ڑC͂̃oXɂF͍̂זE̐ԓʂɕԁDׂĂ̐F̂ƁCoF̂̂̐ڒ͉CXshǂɂ1Zbg΂̕ւƈĂDɂƂȂזE􂵁CϓȐF̐CȂ킿C`2̖זED̂̂F̂͒EÏkCjƂ肩ނƂōĂъj`D̂悤ȃTCNĐF͔̂{ϓɕzD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@F̃TCN</strong>
G1̐F̂́CSiDNAjɕoF̃yA`DG2ւMijɐiނƐF̂͋ÏkD̂̂CזE̗ɂɂ钆ŜLтXshǂô𔽑΂̕Ƃ炦Ĉ邱ƂŁCoF̃yA񂷂iMjDׂĂ̎oF̂񂷂ƃyA͕iMjC2̖זEւƕzꂽ̂זE􂪋NCזE͍ĂG1ւƐiށDF̂̕zɈُ킪F̐̉ߕsNƁCזÊ񉻂₪̈ЂNƍlD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/09/Watanabe-1.e004-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2012/09/Watanabe-1.e004-Fig.1.png&amp;caption=fig1-caption-text]

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@MɂF̂̓</strong>
ԊMOւƐisۂɐF́iFj̋ÏkƂƂɊj̕󂪋NDMOɂĂ͐F̂̎óiԐFjXshǁiΐFjƂ炦ĐF̂̐񂪂͂܂DMɂĂׂĂ̐F̂ƁCMւ̐isNF̃yA͕zDF̂̕zƓɍזE􂪋N2̖זED̍ۂɐF̂͒EÏkĂъj`DF̂̐ڒ͎ô΂̕Ƃ炦ۂɒ͂𐶂ݏoD͐F̂̐̂ߕK{łCڒ̎ꂽF̂͐łȂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/09/Watanabe-1.e004-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2012/09/Watanabe-1.e004-Fig.2.png&amp;caption=fig2-caption-text]


<h2>2DoF̂̐ڒ̐@\</h2>
@Ă番̏uԂ܂ŁCoF̂͂ǂ̂悤ɐڒĂ̂낤H@̖₢ɑ΂铚́CRq[VicohesinjƂ΂^pN̔ɂ炳ꂽ<a href="#R4"><sup>4)</sup></a>DRq[VSmc1CSmc3CScc1CSA4̃TujbgȂ郊O̍\`i<a href="#F3">}3a</a>jCoF̂Ƃ肩ނł̐ڒmƍlĂ<a href="#R5"><sup>5)</sup></a>DRq[Vɂڒ͐F̂̑Sɂ킽m邪CҒœ̍זEłMւƐisۂɐF̘̂rɂڒ͉̑<a href="#R6"><sup>6)</sup></a>i<a href="#F3">}3b</a>jD́CF̘̂rɑ݂Rq[VSATujbgLi[[Plk1ɂ胊_邱ƂɋNĂD_ꂽRq[VWaplƂ΂^pN̂͂炫ɂF̂͂邱ƂmĂ邪CWaplǂ̂悤ɂă_Rq[V̉𗣂𑣐îɂĂ͖𖾂̓_DF̘̂rɂRq[V̏̐IȈӋ`́CoF̂̐ڒ炩ߕIɉĂƂɂĈɊSɕۂ̌߂邱ƂłƍlĂD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@oF̂̐ڒ</strong>
iajRq[V̍\DSmc1CSmc3CScc1iRad21jCSAiSA1CSA2j4̃TujbgȂCO̍\ƂD̃O\ɂ葩˂悤ɎoF̃yA͐ڒƂf񏥂ĂD
ibjMLi[[Plk1ɂRq[ViSATujbgj̃_iPj́CWaplF̘̂rɂRq[V̉𗣂𑣐iDVSV̓zXt@^[[PP2AƋPlk1ɝhRCZgAɂF̂̐ڒی삷DZgAɂڒ̈ێ́CoF̂̂ɂ钣͂̔ѐF̂̐ɕK{̖D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/09/Watanabe-1.e004-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2012/09/Watanabe-1.e004-Fig.3.png&amp;caption=fig3-caption-text]

@̂ƂCF̂̃ZgAƂ΂镔ʂɂĂ̓Rq[V@\܂ʂڒێD́CVSViShugoshinjƂ΂^pN̂͂炫ɂ<a href="#R7"><sup>7)</sup></a>DVSV́CzXt@^[[PP2Aƕ̂`ZgAɋǍ݂邱ƂŁCRq[V_ی삵Waplɂ鏜@\ɝhRƍlĂDqgɂĂ2̃pOoĂCꂼSgo1CSgo2ƖÂĂD̍זEɂĂSgo1oF̂̐ڒɎvȖSCSgo2PP2A̋Ǎ݉̑iڒ̈ێɊ^ƍlĂ<a href="#R7"><sup>7,8)</sup></a>DVSVɂی@\ɂێZgAɂڒ́CoF̂Xshǂɂ蔽ΕɈۂɒ͂𐶂ݏoCɂF͉̂̐\ƂȂDRq[VVSVsꍇȂǐF̂̐ڒĂ܂悤ȏ󋵂ł́CoF̂͐񂷂邱ƂłזEɎU΂Ă܂CזE͐ɐF̂𕪔z邱ƂłȂDZgAɂڒێ邱ƂłׂĂ̐F̂זE̐ԓʂɕԂƁCĎXsh`FbN|Cg@\ĎʁCrL`K[[̂łAPC/Cianaphase promoting complex/cyclosomejCTCNBуZLisecurinj̕NDƂɁCZL̓Rq[V̐ؒfSZp[[̑jQ^pNłC̓̕Zp[[̊ɂƂȂRq[V̐ؒf𑣐ioF̂̕ЂND
@̂قɂCRq[VDNȀC`q̓]ʐɋ@\邱ƂmĂ邪Cł͂̋@\т񉻂Ƃ̊֘AɂĊD

<h2>3DF̂̐ڒɂ^pNُ̈Ƃ</h2>
@yp`wIȎ@ɂRq[Vꂽ_ŁCoF̂̐ڒ@\ƐF̕s萫Ƃ̊֘A͎Ă<a href="#R4"><sup>4)</sup></a>D̂̂ĈזEɂăRq[V̔ʂ̑邢͌񍐂ꂽD܂CF̕s萫咰זË`q͂ɂăRq[VɊ֘A^pNɕψق݂CRq[V̔x̒ቺF̂̐ڒ̌ƂƂɐF̕s萫U邱Ƃꂽ<a href="#R9"><sup>9)</sup></a>Ďʂ́CRq[Vُ̈킪זEɂF̕s萫̌ƂȂ\DɌIȏ؋ƂāCRq[ṼTujbgSA2̔x̒ቺѕψق܂܂ȂזEɂĐF̕s萫̈ƂȂ邱Ƃ񍐂ꂽ<a href="#R10"><sup>10)</sup></a>DSA2XF̂Ɉ`qߒj̍זEɂ1Rs[݂Cы@\pɂɐDSA2̋@\זEł͐F̕s萫݂邪CׂƂɁCOISA2𔭌Ƃ̐F̕s萫͉ꂽD́CRq[Vُ̈킪F̕s萫̌ƂȂ邱ƂÂʂƂD
@Rq[ṼTujbĝقɂCF̂̐ڒɂ^pNُ̈킪F̕s萫₪񉻂𑣐i邱Ƃ񍐂ĂDɏqׂ悤ɁCVSVMɂĐF̂̐ڒێ邽߂ɕK{̖͂C̑咰זEɂSgo1̔ẍُ`q̕ψق񍐂ꂽ<a href="#R11"><sup>11,12)</sup></a>D܂CSgo1̃wembNAEg}EXɂĂ񉻂iƂʂ񍐂Ă<a href="#R13"><sup>13)</sup></a>DRq[V̏ꍇƓlɁCSgo1̋@\ُɂĂF̂̐ڒ̌ѐF̕s萫ώ@邱ƂCoF̂̃ZgAɂڒ̌F̕s萫ɒĂƍlD

<h2>4DF̂̐ڒɂ^pNiF̃pbZW[̂̋Ǎ</h2>
@ł́CZgAɂڒُ̈͂ǂ̂悤ɂĐF̕s萫ЂN̂낤H@Rq[VVSVɕψقזEł͐F̂̐ڒ\ɈێĂԂɂĂCMɂFُ̂̐킪ώ@Ă邱ƂCoF̂̐ڒ̈ێ@\̂̂F̂̐ɂȂ炩̖ƂlDŋ߂̌ʂCRq[VVSV́CF̂̐ɏdvȖF̃pbZW[́ichromosomal passenger complexFCPCj̃ZgAւ̋Ǎ݂ɑ΂ĂdvȖƂɂCF̂̋ϓȕzɊ^邱Ƃ炩ɂȂ<a href="#R14"><sup>14,15)</sup></a>D
@ϓȐF̂̕źCoF̂̓̂΂̕LтĂXshǂɂ邱ƁiڑjɂBDCXshǂ̓̂ւ̐ڑ͍ŏ̓_ɋN邽߁CoF̂ЕɈĂ܂悤ȈڑN肤D̂悤ȌڑmC͂̂CMLi[[Aurora B܂ސF̃pbZW[̂ł<a href="#R16"><sup>16)</sup></a>i<a href="#F4">}4a</a>jDF̃pbZW[̂́CAurora BCINCENPCSurvivinCBorealin4̃^pNȂCôɂ͂܂ꂽCi[ZgAƂ΂̈ɋǍ݂DAurora B̊̓Ci[ZgA𒆐SƂzCڑ̂悤Ɏô̂ɒ͂Ȃ󋵂ł͓̂܂ŊyԂ悤ɂȂ<a href="#R17"><sup>17)</sup></a>DƁĈ̊OɈʒuXshǂƂ̐ڑɂăC^[tF[XƂĂ͂炭KMNlbg[NƂ΂铮̃^pNiNdc80CDsn1CKNL1j_悤ɂȂi<a href="#F4">}4b</a>jD̃^pÑ_̓XshǂƂ̐ea𕉂ɐ䂷邱ƂĂC̃_ƂȂCڑƂf񏥂ĂDۂɁCAurora B̊jQƁCڑ̑ɂƂȂFُ̂̐킪ώ@DڑĒ͂ƁCôCi[ZgA痣邱ƂɂCAurora Bɂ铮̃^pÑ_x͒ቺɍpD܂Cɂ킦C͂̐̂ɂAurora BɝhRzXt@^[[łPP1PP2AǍ݂C̃^pÑ_x͒ቺD̂悤ɂāCڒɂ萶ݏo钣͂Aurora Bɂڑ̏C@\邱ƂɂC悭ڑmƍlĂD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@Aurora Bɂ铮̂ƃXshǂƂ̐ڑ̏C</strong>
iajAurora B͎ô̂̃Ci[ZgAɋǍ݂DôЕ̋ɂɗRXshǂɂƂ炦ꂽꍇɂ͎ôɒ͂͐ȂD̂悤Ȉڑł́ĈCi[ZgAɋ߂̈ɈʒuAurora B̂͂炫ɂs艻Dô̋ɂɗRXshǂɂ蔽΂̕Ɉꂽڑł́Ĉ̓Ci[ZgA痣ꂽ̈ɈʒuAurora Bɂs艻܂ʂD
ibjAurora B͔ǂƂ̃C^[tF[XƂȂKMNlbg[NƂ΂铮̃^pN_iPj邱ƂɂĈƔǂƂ̐ڑs艻DAurora B̊̓Ci[ZgAɋ߂̈قǍzDڑmꓮ̂Ci[ZgA痣ƁCAurora B̊ቺƂƂɁCzXt@^[[łPP1PP2ÂɋǍ݂KMNlbg[N͒E_DɂǂƓ̂Ƃ̐ڑ艻D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/09/Watanabe-1.e004-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2012/09/Watanabe-1.e004-Fig.4.png&amp;caption=fig4-caption-text]

@F̃pbZW[̂̃Ci[ZgAւ̋Ǎ݂̓Xshǂ̐ڑɂC@\͂炩邤ŕK{ł邪C̋Ǎ݉̋@\͓ɂ܂ĂDM҂̌́CRq[VMLi[[Haspin̖F̃pbZW[̂̋Ǎ݂𐧌䂷邱Ƃ񍐂<a href="#R14"><sup>14)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/1488" target="_blank">V_r[</a> łfځjDHaspin̓qXgH33Ԗڂ̃XIjc_Li[[łCM̍זEɂẴ_̓ZgAɂĊώ@D̃_͐F̃pbZW[̂̍\^pN̂ЂƂłSurvivinƂ̒ڂ̑ݍpF̃pbZW[̂ZgAւƋǍ݂D܂ŁCHaspinZgAɂĂ̂݃qXgH33Ԗڂ̃XIjc_@\͒mĂȂDypHaspin̓Rq[VƒڂɌ邱ƂCHeLaזEł̓Rq[VRNAi@ɂmbN_EזEɂăZgAɂqXg_F̘̂rւƊgU悤ώ@ꂽD̂ƂCMɂăZgAɈێRq[VCHaspin̋@\F̃pbZW[̂̋Ǎ݂𐧌䂷邱ƂꂽD܂CM҂̌́CVSVSgo1CSgo2̂ꂼꂪF̃pbZW[̂̍\^pN̂ЂƂBorealinƒڂɌCF̃pbZW[̂ZgAւƋǍ݂邱Ƃ<a href="#R15"><sup>15)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/1008" target="_blank">V_r[</a> łfځjDVSVBorealinƂ̑ݍp̓TCNB-CDK1̂ɂBorealiñ_ɂ董iD̂悤ɁCoF̂̃ZgAɂڒɂ͂炭Rq[VуVSV́Cڑ̊mɕKvȐF̃pbZW[̂̋Ǎ݂䂵Ă邱Ƃ킩D

<h2>5DCi[ZgA-VSVlbg[NƂ</h2>
@F̂̓ڑɕK{̖F̃pbZW[̂ƃVSVƂ̂̋̕Ǎ݂𐧌䂷lbg[ŃgCi[ZgA-VSVlbg[NhƂ΂<a href="#R18"><sup>18)</sup></a>i<a href="#F5">}5</a>jDMLi[[Bub1ɂ胊_ꂽqXgH2A120Ԗڂ̃XIjcweN}`^pNHP1́CVSV̒ڂ̑ƂȂ邱ƂmĂ<a href="#R19"><sup>19,20)</sup></a>DHaspinɂqXgH33Ԗڂ̃XIjc̃_Bub1ɂqXgH2A120Ԗڂ̃XIjc̃_́CF̃pbZW[̂ƃVSVƂ̂̕Ci[ZgAɋǍ݂邽ߕK{̖͂2̃qXg}[NłCCi[ZgA-VSVlbg[NɂĒSIȖ͂ĂDBub1̋@\sS͓ڑُ̈זEɐF̕s萫炵C񉻂ЂNƍlDۂɁCqĝזEɂĂBub1̕ψق񍐂ĂCBub1̃wembNAEg}EX͐F̕s萫<a href="#R21"><sup>21)</sup></a>D܂CHP1͑̂זEɂĔ̒ቺώ@Ă<a href="#R22"><sup>22)</sup></a>D

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@Ci[ZgA-VSVlbg[N</strong>
MLi[[Bub1ɂqXgH2A120Ԗڂ̃XIjc̃_iPj́CVSVSGO`[tƂ̑ݍpVSVǍ݉DF̃pbZW[́iCPCjMLi[[Haspinɂ胊_ꂽqXgH33Ԗڂ̃XIjcɒڂɌ邱ƂŋǍ݉iD2̃qXg̃_C͐F̃pbZW[̂ƃVSVƂ̂̋̕Ǎ݂𐧌䂷qXg}[NłC̋Ǎ݂𐧌䂷lbg[NCi[ZgA-VSVlbg[NƂԁDVSṼRChRC̈ɂ̓zXt@^[[PP2ACZgAɂăRq[Vی삷D܂CRq[VHaspin̑ɂȂƍlĂCqXgH33Ԗڂ̃XIjc̃_𑣐iDVSV̂P-V-I`[tHP1Ƃ̑ݍpZgAւ̋Ǎ݂Ɋ^DHP1Suv39Hɂ胁`iMjꂽqXgH39Ԗڂ̃Wc𑫏ƂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/09/Watanabe-1.e004-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2012/09/Watanabe-1.e004-Fig.5.png&amp;caption=fig5-caption-text]

@Suv39H1т̃pOłSuv39H2́CF̂ɂHP1̑ƂȂqXgH39Ԗڂ̃Wc̃`yfłDSuv39H1Suv39H2̃_umbNAEg}EX͎oF̂̐ڒُ̈킨ѐF̕s萫ᇌ`̃XN܂Ă邱Ƃ񍐂Ă<a href="#R23"><sup>23)</sup></a>D܂CSuv39H1Suv39H2ƝhRE`yfłJMJD2t@~[^pN̉ߏ蔭CF̕s萫̂זEɂĕ񍐂Ă邱Ƃ<a href="#R24"><sup>24)</sup></a>CqXgH39Ԗڂ̃Wc̃`̐́CזÊ񉻂ɂďdvȈӖƍlDJMJD2t@~[^pN̉ߏ蔭F̕s萫ЂN@\ɂĂ͖炩ɂȂĂȂCHP1уVSV̋Ǎݐ̒ቺĂ\lD
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<h2></h2>
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<h2> </h2>
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</ol>
<div class="au-profile">
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<span class="author">O IiiYuji Tannoj</span>
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<strong>n ÓTiYoshinori Watanabej</strong>
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</div>
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