]̋@\ƃ~NOA

<strong>aO<sup>1</sup>Ex _<sup>2</sup>E{{q<sup>1</sup>Eq~<sup>2</sup></strong>
i<sup>1</sup>_ˑww@w VXewC<sup>2</sup>w ̍P퐫Bj
emailF<a href="mailto:hirowake@med.kobe-u.ac.jp">aO</a>
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̈Zr[, <strong>6</strong>, e007 (2017)@<a href="http://dx.doi.org/10.7875/leading.author.6.e007">DOI: 10.7875/leading.author.6.e007</a>
Hiroaki Wake, Hiroshi Horiuchi, Akiko Miyamoto & Junichi Nabekura: <strong>Microglia for brain functions.</strong>

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<h2>v </h2>
@]̋@\͓dCIȊɂSDȂCdCIȊSj[͔]̖20߂ɂCc̖80̓OAזEƂ΂זEɂ肵߂DOAזE͐_oH̊̍P퐫SƂCߔNCڂĂDOAזËłC_onɂėB̖ƉuזEł~NOÁCaԂQɂČ`Ԃ傫ωC^̃~NOAւƕω邱ƂmĂD܂ł͊^̃~NOA̕aԂQɂɂďdvȌȂĂCZpIȖ肩~NOA̐Iȋ@\ɂĂ͕sȓ_܂܂łDߔŇwZp̔Bɂ萶̂ɂC[WO\ɂȂC~NOA̐Iȋ@\炩ɂƂƂɁC̋@\̑rɂЂN鎾ڂ悤ɂȂĂD̃r[ɂẮC~NOA̐Iȋ@\ɂĉƂƂɁC~NOA̐Iȋ@\̑rɂ萶鎾ɂċc_D

<h2>͂߂</h2>
@̂͊OE̊ٕ̈ɑ΂h䔽CƉuN@\ێDƉu͊Öٕr͂炫CRɑ΂ߏȖƉuNƂɂAM[NC܂CȂɑ΂ƉuNƂɂ莩ȖƉuЂNDIȖƉuтɂ閝ǂ͂Ӑ̎Ȃǂ܂܂ȕaԂɊ֗^邱ƂmĂD]Oł͂ȂC_̊bIȕaԂƂĖǂ݂̑ĂD
@_onɂăj[߂͖̂20ɂCق3ނ̃OAזE݂c̖80߂ƂĂi<a href="#F1">}1</a>jD̂CISfhTCgуAXgTCg͊OtɗRDISfhTCg͐̌`SC_o̓`x𐧌䂷DAXgTCg͐_o`B̐䂨ьt]֖̌`ɂ]̊ێDCtɗR~NOA͒_onɂB̖ƉuזEłD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@OAזE̎ނы@\</strong>
OAזEɂ́CAXgTCgCISfhTCgC~NOADAXgTCgуISfhTCg̓j[ƓOtɗRC~NOA͒tɗRD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/09/Wake-6.e007-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2017/09/Wake-6.e007-Fig.1.png&amp;caption=fig1-caption-text]


<h2>1D~NOA̐</h2>
@܂ŁC~NOA̗RɂĂ͂Ȃ炭c_Ă<a href="#R1"><sup>1)</sup></a>CߔNCRunx1pזEn̉͂ɂِ7.5̗Xɑ݂OזEɗR邱Ƃ炩ɂCɁCŠɂ茌t̏zs\ɂȂNa<sup>+</sup>-Ca<sup>2+</sup>A1̃mbNAEg}EXɂĔ]ɂ~NOA̐ƂCِ8.5`10Ɍ`znĔ]ɐZ邱Ƃꂽ<a href="#R2"><sup>2)</sup></a>D
@~NOA͐UĔɊɓƂmĂ<a href="#R3"><sup>3)</sup></a>D_oł̓^ɂ_o}ƃ~NOA̓ˋN̉^ƂC~NOA̓͐_oɈˑIłDߏȐ_oɑ΂C~NOAړIɂ̎ɐڐGdʂ}邱Ƃɂ_o̕یɊ^邱ƂC~NOA̓ˋN̗U̓j[̑̐ςɈˑ̃AjI`lATP̕oɈˑ邱Ƃ킩<a href="#R4"><sup>4)</sup></a>D܂CP[WhO^~_V邱Ƃɂj[ɐ_oNƃ~NOA̓ˋN_oNj[ɋ߂ÂCpannexin-1̑jQ܂łvxlVh̓^ɂ~NOA̓ˋN̐L͗}DATP̎êłP2ê̑jQ܂łAs[[X~̓^ɂ~NOA̓ˋN̐L͑jQ邱ƂC_oɈˑIpannexin-1w~`loATPdvłƍl<a href="#R5"><sup>5)</sup></a>DɁC~NOA̓ˋN̓[U[ɂ鑹ʂɏWςCATP̎êłP2Y<sub>12</sub>̑jQɂ}邱ƂP2Y<sub>12</sub>ɈˑIł邱Ƃ炩ɂꂽ<a href="#R6"><sup>6,7)</sup></a>DQ̍ۂłȂCȏԂɂĂ~NOA5Ԃقǂ̒ZԂVivXƐڐGĂ邱Ƃ2qp̃C[WOɂ薾炩ɂꂽD܂Cl̎@pč[ǂ̗̎͂̈ɂ~NOAƃVivX̐ڐGώ@ƂC~NOAVivXO̍\łu[gɐڐGCڐGɂu[g悤ώ@C~NOAVivXƕ񍐂ĂD[ǂ̗̎͂̈ɂĂ͑_oH̋@\㏞邽ߐ_oHĕҐ邱ƂmĂ邱ƂC~NOA͐_oH̍ĕҐɂ֗^ƍl<a href="#R8"><sup>8)</sup></a>D̂悤ȃ~NOA̓ɂCBѐnɂăj[уVivX̐͐䂳C_oȞ`ɂ̊䂳D

<h2>2D~NOAɂj[̐̐</h2>
@B̑ɂăj[͂̑啔邱ƂmĂDj[̓A|g[VXɂK؂Ȑێ_oH`DXɗR~NOA͊`ԂƂȂ蒆_onɐNC̒蒅n͍邽ߊɓƓɁC_fpĐ_oזEɔ\IɃA|g[VXЂNCÐHɂ菜<a href="#R9"><sup>9)</sup></a>D̂Ƃɂj[̐̐Ɋ֗^邱Ƃ]]玿ȂǕ̗̈ɂĒmCɁC̈悲ƂɓِƂmĂ<a href="#R9"><sup>9,10)</sup></a>D̂悤ɁC~NOA͍זE̎͂̊𐮂邱ƂɂC_oH`Ƃ̍P퐫̈ێSDɁCCnɂĂ͐̂ɂȂĂj[V邱ƂmĂ邪Cł̃j[A|g[VXND̃A|g[VXNj[̏~NOASƂ炩ɂĂ<a href="#R11"><sup>11)</sup></a>D

<h2>3D~NOÃVivXւ̊֗^</h2>
@VivX̓j[̂`B镔ʂłC̃j[ɂƍl񏈗ɂĔɏdvȕʂłD~NOA͂̃VivXƓٓIɑݍp邱ƂmĂD1900NɁCVivXXgbsOƂۂ񍐂ꂽD́Cʐ_oؒfۂɊʐ_o߂̍זÊ̕ɂāCזÊƍזÊɃVivX`VivXOIƂ̂Ƀ~NOA荞ŃVivX`BjQƂ̂ł<a href="#R12"><sup>12)</sup></a>Dľۂ́CMBCGۂ]玿ɒƐ̍זEɑ΂Ă邱Ƃ炩ɂĂC_onɂĂVivXXgbsO̐邱Ƃ킩Ă<a href="#R13"><sup>13)</sup></a>D܂CזÊ̎͂ɂ͗}̃VivX`Ă邪CVivXXgbsOɂ}̃VivXj[̋㏸邱ƂɂCA|g[VXjQBcl-1_o̕یpBDNFȂǂƕ񍐂ĂC~NOA_o̕یɂ͂炭Ƃl<a href="#R14"><sup>14)</sup></a>D
@VivX͔B̑ɂĉߏɌ`CъoɈˑď邱ƂmĂD̂悤ȉߒɂ萳Ȑ_oH͐kC]ɂēK؂ȏ񏈗ȂD_onɒ蒅~NOA͓ˋNL΂`Ԃ񊈐^ɕωCVivX̌`я̉ߒɊ֗^邱Ƃ炩ɂꂽi<a href="#F2">}2</a>jD܂ł̔|{זEpɂCP|{Cñj[ɂă~NOAYC^[CL10ɂVivX̌`ЂN邱Ƃ炩ɂĂ<a href="#R15"><sup>15)</sup></a>D

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@~NOAɂVivX̋@\̏C</strong>
~NOA͔B̑ɂăVivX̌`𑣐iCɂ̐_oȞ`ɍpDɁCVivXÐH邱ƂɂVivX̏̉ߒɂ^D܂CVivX̉YIȕωɂ֗^D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/09/Wake-6.e007-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2017/09/Wake-6.e007-Fig.2.png&amp;caption=fig2-caption-text]

@܂C2qp̃C[WOɂĈɂĂnɃ~NOAVivX̌`Ɋ֗^邱Ƃ炩ɂꂽD^wK̍ۂɑ]玿̉^ɂăVivX̉YIȕωCȂ킿CVivX̌`яi邱ƂmĂD̃VivX̌`C~NOA`Iɏ}EXł͌邱Ƃ炩ɂꂽDɁC~NOAɓٓIBDNF̔jQƁClɃVivX̌`jQ^wKQꂽƂC~NOA͉^wK̍ۂɃVivX̌`𑣐i邱Ƃɂ^wKɕKvȃVivX̉YIȕωЂNƂ炩ɂꂽ<a href="#R16"><sup>16)</sup></a>i<a href="#F2">}2</a>jD̂悤ȃVivX̌`ւ̊^́Cn݂̂Ȃ炸BɂĂND~NOA͔B̑̓̎ɂĊ`ԂD̎ɂāC~NOA͎ˋNƐڐG邱Ƃɂ薢nȃXpCƂĒ`tB|fBǍ`𑣐i邱ƂꂽD͎ɓٓIłC̎̈ȍ~ł̓~NOAƎˋNƂ̐ڐGɂLӂȃtB|fBǍ`͋NȂDɁCegTCNɈˑă~NOAɓٓIɏłnpC~NOA̎ɓٓIɏƂCnɂXpC̐̌VivXd̕px̒ቺF߂ꂽƂC@\IȃVivXĂ邱Ƃ炩ɂꂽD̃~NOA}EXɂđ]ɂw\̂̌dCwIɌ؂ƂC~NOAnȃXpČ`𑣐i鎞ɂāC_oH`Ƃ4w2w/3wւ̋@\IȌቺDȂ킿CBɂă~NOA̓VivX̌`𑣐iCٓIȐ_oȞ`Ɋ^邱Ƃ炩ɂꂽ<a href="#R17"><sup>17)</sup></a>D
@_oȞ`̉ߒɂẮCB̏ɉߏȃVivX`ꂽ̂CnȃVivXCKvȃVivX邱ƂɂK؂Ȑ_oH`<a href="#R18"><sup>18)</sup></a>D̂悤ȃVivX̏̉ߒ͐_oɈˑIɋN邱ƂmĂD܂ŁCዅԖ_oߍזE̓˂鎋̊OĜɒڂȂC5`7ɋNVivX̊荞݂Ƀ~NOA֗^邱ƂꂽDԖ_oߍזEɂĂ̓VivX荞܂邱ƂɂԖ_oߍזEƓɂዅ̓͂Αɂዅ̓͂DʂɂȂDʐ`D̂ƂC̊ዅёΑ̊ዅɈقȂF̐Ff𓊗^CԖ_oߍזE̎ɂ_oOI̐Fɂǂ炩̓˂ł邩ʂł悤ɂʁCVivX荞܂鐶5`7ɂāCꂼ̐Ff܂ރVivXIԖ_oߍזẼ~NOAɎ荞܂Ă̂ώ@ꂽD܂C~NOAƉuFɂWdqpĊώ@ƁC~NOA̓ɃVivX\荞܂Ă悤݂邱ƂCԖ_oߍזẼVivXI~NOAɂÐH邱ƂlꂽDVivX̏̉ߒɂĐ_o̎アVivX邱Ƃ炩ɂĂ<a href="#R18"><sup>18)</sup></a>D̂߁CVivX̊荞݂͓̊ዅ̓͂ΓIɎアƂɂ萶ƍlDŁCΑ̊ዅɐFfƂƂɐ_o}eghgLV𓊗^CΑ̖Ԗ_oߍזE̐_o}}EX̖Ԗ_oߍזEɂă~NOAώ@ƁCΑ̊ዅ瓊˂Ă鎲I~NOAɑ荞܂ĂƂCBɂ~NOAɂVivX̏_oɈˑIɐ邱Ƃ炩ɂꂽ<a href="#R19"><sup>19)</sup></a>Dľۂ͎łȂC傤ǃVivX̊荞݂̎ɂ鐶3`4Tڂ̃}EX̑]玿o␶̔B̊CnɂĂώ@Ă邱ƂC~NOÃVivXɑ΂镁ՓIȑݍp̂ЂƂłƍlD
@̂悤ȃ~NOAɂVivX̏̕q@\ƂāČnC3C1q̊֗^ĂD̂͑SgɂĐNĂâɑ΂ŏ̖̐h@\SĂCrׂâɕ̂邱ƂɂIv\jN}Nt@[WȂǂɂÐHp₷ȂD܂C̍p͊O̕âɑ΂ĂłȂCA|g[VXg̍זEVpɑ΂Ă邱ƂmĂDۂɕWIɌ̂łC3YߒƂẮCÓTIȌoHCoHCN`oH3mĂ邪CÓTIȌoHɂC3YۂɃJXP[h̊JnƂȂ̂C1qłD5̃}EXɂĖԖ_oߍזEɂC1qĂC~NOAɔC3̎êłCR3̃mbNAEg}EXɂă~NOAɂVivXOI̎荞݂邱ƂC̃^pN~NOAɂVivX̏Ɋ֗^邱ƂĂ<a href="#R19"><sup>19)</sup></a>DɁCԖɑ݂AXgTCgoTGFԖ_oߍזEɂC1q̔𑣐i邱Ƃ񍐂ĂC~NOACj[CAXgTCgƂ̍זE킪ċ@\邱Ƃɂ_oHK؂Ɍ`Ă邱Ƃ炩ɂĂĂD܂C_onɂĂ̓~NOAɓٓIɔeCX3CR1VivX̏̉ߒɊ֗^邱ƂĂDCX3CR1}EXɂĂ̓~NOA̓ɂ݂ÐHꂽVivXCVivX̏̉ߒɂ錸ቺ邱Ƃ炩ɂꂽD܂̂قCP2Y<sub>12</sub>VivX̏Ɋ֗^邱ƂĂ<a href="#R20"><sup>20,21)</sup></a>D
@~NOA̓VivX̉YIȕωɂ֗^邱ƂmĂD~NOAɓٓIBDNFƃVivX̍\IȉYQCwKjQ邱Ƃ炩ɂꂽ<a href="#R16"><sup>16)</sup></a>D̂ƂC~NOA^wKȂǂ̃VivX̉YIȕωv]̍@\ɕK{ł邱ƂD
@ɁC^pNłCD200̌ɂ莩RƉuɂTollleTLR2TLR4̔㏸C|ɑ΂TNF̎Y債ƂCCD200-CD200ěoH~NOA̐IȏԂێ邱Ƃꂽ<a href="#R22"><sup>22)</sup></a>DɁCCD200CnXCXɂĒ͒ቺĂCTNF̓^ɂ钷̒ቺƗގĂD܂C|̓^ɂCD200̌ɂ钷̒ቺ͕qɂȂ邱Ƃ킩<a href="#R22"><sup>22)</sup></a>DāCCD200-CD200ěoH̓~NOA̐_ỏYɂ^ƍlD
@CZx̃|̓^ɂTolllěoHĔVivXd͑DPU.1}EXɂĂ̓~NOAC̔VivXd̑jQ邱ƂC~NOATolllěoHVivXd̑ɕKvł邱Ƃ炩ɂꂽ<a href="#R23"><sup>23)</sup></a>DɁCǃf̊Cn}XCXɂĂ̓VivX`BŁCђ}͂ƂɑjQ<a href="#R24"><sup>24)</sup></a>D̃VivX`B̑GluN2BGluA2̒ቺƑւCGluA2̌CAMPAê̑jQC~mTCNɂ鉊ǂ̗}ɂ񕜂邱ƂꂽD̂悤ɁC~NOÅɂVivX̉Yቺ邱ƂĂD
@~NOAɓٓIɔeCX3CR1}EXɂĂ̓VivX̉Y}CɂƂȂCnɈˑIȔFm@\ቺ邱Ƃ炩ɂꂽ<a href="#R25"><sup>25)</sup></a>DCX3CR1̃KhłCX3CL1̎hɂC^[CL1̎YЂNCGCRTmCho邱ƂɂVivXOI̐_o`B̕oi<a href="#R26"><sup>26)</sup></a>D
@ŁC}̃VivXɑ΂~NOA̋@\ɂĂ͕sȓ_D_o𑹏ۂɂ́CҐɂ~NOABDNF̕oK<sup>+</sup>-Cl<sup>-</sup>Â̋@\ቺCNQej[̃VivXɂGABA<sub>A</sub>êCl<sup>-</sup>̊OdUCɂ苻㏸ɊoߕqN<a href="#R27"><sup>27)</sup></a>D3dqp񍐂ɂẮC~NOA}̃j[̑OI菜Ƃ炩ɂĂ<a href="#R14"><sup>14)</sup></a>DdCwIȎɂC̗}̃VivX̒E}玿j[̓΂𑝉邱Ƃ炩ɂꂽD_ȏ̓JWˑveCLi[[IV̊CREB̃_ЂNCRA|g[VX^pNщh{q̔UāCj[̃A|g[VX}DɁChꂽ~NOA̓vX^OWE<sub>2</sub>YCOV쓮VivX̐_oɈˑY̐āC}̃VivX̋@\̐SƂ炩ɂĂ<a href="#R28"><sup>28)</sup></a>

<h2>4D~NOAƕa</h2>
@Ǌ֘AɂẮCƗ}̃oẌُƁCЉš@уR~jP[VQƂ̑ւwEĂDǊ֘Å҂̔]ɂĂ͖nȃXpC̖x̏㏸mĂ<a href="#R29"><sup>29)</sup></a>DɁCُȃVivX\F߂Ă<a href="#R30"><sup>30)</sup></a>DB̑ɂĉߏɌ`ꂽVivX荞܂邪CǊ֘Â悤Ȑ_oBQɂĂ̓VivX̊荞݂ɋNȂʁCVivX̖xߏɂȂ邱Ƃ֘AƍlĂD܂ŁCCx3cr1}EXɂāCB̉ߒɂ~NOAɂVivXÐH̏Q񍐂Ă邪<a href="#R20"><sup>20)</sup></a>CɁCVivX̋@\ُ̈킨юЉIȍsُ̈킪ЂN邱Ƃꂽ<a href="#R31"><sup>31)</sup></a>i<a href="#F3">}3a</a>jDɁCǊ֘Å҂ɂċ@\ቺƍlĂOя玿я]ɂă~NOAĂ邱Ƃ킩Ă<a href="#R32"><sup>32)</sup></a>D܂CǊ֘Å҂̔wOOO玿ɂ13l̂9lɃ~NOÅF߂Cł͍זÊ̑̐ςCDł͍זE̖x㏸Ă<a href="#R33"><sup>33)</sup></a>DɁCǊ֘Å҂̔wOOO玿ɂĂ̓~NOAj[̋߂ɔzuĂC~NOA̓ˋNj[Ƃ肩ނ悤ώ@Ă<a href="#R34"><sup>34)</sup></a>D܂CǊ֘Å҂ɂċ@\̒ቺ̈ɂ̓~NOÅVivX̖x̏㏸邱ƂC~NOÅƕaԂƂ̊֘AĂD܂CǊ֘Å҂ɂĂ͗̈̂̌̐Ǝ㐫wEĂ邪<a href="#R31"><sup>31)</sup></a>C~NOAɂVivX̏̉ߒƗ̈̂̌Ƃ̊֘AĂ<a href="#R19"><sup>19,20,31)</sup></a>D

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@~NOAɂVivX̐@\̔j]Ǝ</strong>
iajǊ֘ADCX3CR1͖̌nȃVivX𑝉邾łȂCЉIȍsjQD
ibjAcnC}[^̔Fm@\QDA~Ch^pÑIS}[C1qC3C3êĂWIƃ~NOAVivXÐHD܂CTDP43̋@\̔j]̓~Ch^pÑIS}[ÐHѕ𑣐iCVivXÐHiD
icjSgGe}g[fXDI^C^[tFVOȋjQɂSgGe}g[fX̃f}EXɂĒ_ȍǏ󂨂уVivX̏}D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/09/Wake-6.e007-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2017/09/Wake-6.e007-Fig.3.png&amp;caption=fig3-caption-text]

@RettǌQ͎Ǘl̏Ǐ_oBQłCXF̂ɃR[h<em>Mecp2</em>`q̕ψقɂЂN<a href="#R35"><sup>35)</sup></a>C܂ŁCMecp2̓j[݂̂Ȃ炸CAXgTCgC~NOACISfhTCgɂ邱Ƃ킩ĂDMeCP2~NOAj[уVivXɑ΂Ő𔭊邱Ƃ͖炩ɂĂ̂<a href="#R36"><sup>36)</sup></a>Ĉɂ~NOAɓٓIMecp2̌̉eɂĂ͈vĂȂ<a href="#R37"><sup>37,38)</sup></a>DVȒmƂāCRettǌQ̍ŏIXe[WɂāC~NOA͑OVivXߏɎ荞ނƂɂaԂ̌`Ɋ^邱Ƃ炽߂ĎꂽDɁC~NOAɓٓIMecp2̋@\l^̕ψق邢͋@\^̕ψق́C~NOAɂߏÐHCVivX̌Csُ̈ɂ͂܂eȂƂmFꂽ<a href="#R39"><sup>39)</sup></a>DāC~NOARettǌQ̍ŏIXe[Wɂċ@\\ꂽD
@AcnC}[^̔Fm@\QɂẮC̏ɂVivX̋@\̑rwEĂ<a href="#R40"><sup>40)</sup></a>D܂ŁC~NOÂЂN]ɂ閝Iȉǂ_oŐɂ펿IȎЂNƍlĂDCRǖ򂪗LłȂƂC\IȍRǐTCgJCłC^[CL10ނǏƕ񍐂Ă邱ƂȂǂ<a href="#R41"><sup>41)</sup></a>CIȉǂ}邾ł͕aԂ̉Pɂ͂ȂȂƂ炩ɂĂDA~Ch^pN̏ɂ̓~NOAɂÐHdvłƂC~NOA}EXɂĂA~Ch^pNɂ͌ȕωF߂ȂƂC~NOAɂA~Ch^pNÐHɂĂ͋c_ÂĂ<a href="#R42"><sup>42)</sup></a>D̂悤ȃ~NOA2ʐaԂɊ֗^C̐isɂ邱Ƃ悤ɂȂĂDBɂă~NOAC1qɕWꂽnȃVivX邱ƂɂK؂Ȑ_oH`邱ƂĂ邪<a href="#R19"><sup>19)</sup></a>CAcnC}[ãf}EXɂăv[N`ȑÕVivXC1qĂ邱ƂCA~Ch^pÑIS}[C1q𑝉邱Ƃ炩ɂꂽDɁCA~Ch^pÑIS}[̓^ɂ}fɂāC~NOAC3êVivX邱Ƃꂽ<a href="#R43"><sup>43)</sup></a>DɁC~NOAC3ê͔]ҐtɂA~Ch^pN̏𐧌䂷邱Ƃ炩ɂꂽ<a href="#R44"><sup>44)</sup></a>D܂CC3̌A~ChÕ^pN邢̓vZj1ɂ_oϐɑ΂یIɋ@\邱Ƃꂽ<a href="#R45"><sup>45)</sup></a>D̎CBɂ~NOAɂVivX̏̋@\AcnC}[^Fm@\QɂĈُɂȂCKvȃVivX邱ƂɂaԂЂN邱Ƃꂽi<a href="#F3">}3b</a>jDAcnC}[ãf}EXɂẮC~NOAɂTDP43̌A~Ch^pNCɁCIȃVivX̌Ƃ킩<a href="#R46"><sup>46)</sup></a>i<a href="#F3">}3b</a>jD܂CO^Fmǂ̊҂ɔF߂progranuliň\\[̌ѕ̂̉ߏȎYЂNC~NOAɂIIȃVivX̊荞ُ݂̈킨эsُ̈C̕aԂɂĂ͕̂̊}邱Ƃɂsُ̈킪P邱Ƃ炩ɂꂽ<a href="#R47"><sup>47)</sup></a>D
@gpm\[}̊ɂ鐇QfɂāC~NOAĂ邱ƂƉugDIȎ@ɂ薾炩ɂĂ<a href="#R48"><sup>48)</sup></a>D}邢͖IȐ̔D͉ǔNDqgњMނɂāC̔Dɂ茌̔̐͑CC^[CL1CC^[CL6CTNFƂǐTCgJC̑ЂNCt]֖̓ߐi<a href="#R49"><sup>49)</sup></a>DߔNC~NOAɂ͊TY݂̑邱ƂĂCԂ̂قƔrēˋN̒␔`ԂقȂ邱ƂmĂ<a href="#R50"><sup>50)</sup></a>D̂߁CTYɂă~NOA̋@\قȂ\DɁC̔DVivXÐH𑣐iƂʂCIȐ̕s͉ǐ^pN̔̏㏸ƂȂȂ`ԓIȃ~NOÅЂNƂĂ<a href="#R51"><sup>51)</sup></a>D
@SgGe}g[fX͎ȖƉûЂƂŁCN̏ɍDCSg̉ǐQNDMCJC̏ďCaςƂSg̏ǏC畆SCtǏCVǏǏƂIȏǏ̂قC_ȍǏƂzCC_ʂĂ݂DRNMDAe̍ŔCR{\[PŔCRR̂Ȃǂ̎ȍR̂̎ŶɈˑ̃A|g[VXF߂C_ȍǏƂ̊֗^wEĂ邪Cmȋ@\͉𖾂ĂȂ<a href="#R52"><sup>52)</sup></a>D_ȍǏ͏ɐff邱ƁC_ȍǏ͎ȖƉuԂɂĂςȂ邱Ƃ񍐂Ă<a href="#R53"><sup>53)</sup></a>CgDɂƉȕԂ_ǏK肷\ڂĂDȂ킿CSgGe}g[fX̃f}EXłMRL/lpr̍L}EX쐻ƁCSg̎ȖƉuقڏC_ȍǏ͐܂܂ł<a href="#R53"><sup>53)</sup></a>DāC̃f}EXɂ钆_ȍǏ͂񐶂ƕstIȂ̂ł̂C邢́CƗ̂ł邱ƂDSgGe}g[fX̊҂̎悵~NOA̍זEłBV2זE邱Ƃ炩ɂĂ<a href="#R54"><sup>54)</sup></a>D_ȍǏ悷SgGe}g[fX̃f}EXɂĐ钆_ȍǏ󂨂уVivX̏́CI^C^[tFVOȋjQɂ}ꂽ<a href="#R55"><sup>55)</sup></a>DɁCI^C^[tFɂ~NOÅɂj[邢̓VivXɊ֘A镨ÐH邱Ƃ炩ɂꂽi<a href="#F3">}3c</a>jD

<h2></h2>
@`q̖̔ԗIȉ͂C~NOAɂ`q̔ɂ͗̈ɓٓIȑl݂̑邱Ƃ񍐂ꂽ<a href="#R56"><sup>56)</sup></a>DɁC̈悲ƂɃ~NOÃ^[I[o[قȂĂCx~Ԃ̃~NOA̓_Ɏȕ̂ɑ΂CaԂ̍ۂɂ͓̃~NOAN[iɑB邱ƂꂽD܂CB̂̂ɂ̓A|g[VXтق̗̈ւ̊gUɂ~NOA͌ȏԂɂǂ邱Ƃꂽ<a href="#R57"><sup>57)</sup></a>D~NOǍ`Ԃ͔]̗̈ɂĈقȂ邱ƂmĂC~NOȂlɂ͂̂悤ȋN̈Ⴂ̂ȂD~NOA̐ɂ͐̂邱ƂĂ<a href="#R58"><sup>58)</sup></a>Cʂɂ蔭ǗdǓxɍق̔F߂鎾ɂĂ̓~NOA̐\lD~NOA͔B̑]ɑ݂邽߁C~NOÄُ͐_oȞ`Cǂɑ\_oBQȂǂɊ֗^\D

<h2> </h2>
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</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">a OiHiroaki Wakej</span>
F2007N Ésww@w CCN w C2009N čNIH National Institute of Child Health and Human DevelopmentC2012N bw C2014N w yoāC2016N_ˑww@w D
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URLF<a href="http://www.med.kobe-u.ac.jp/nature/index.html" target="_blank">http://www.med.kobe-u.ac.jp/nature/index.html</a>

<strong>x  _iHiroshi Horiuchij</strong>
w D

<strong>{{ qiAkiko Miyamotoj</strong>
_ˑww@w D

<strong>q ~iJunichi Nabekuraj</strong>
w D
</div>
? 2017 aOEx _E{{qEq~ Licensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
