ÂזE^ƍזEɐ

<strong> E쒼l</strong>
ibw `Ԍ`j
emailF<a href="mailto:msuzuki@nibb.ac.jp"> </a>C<a href="mailto:nueno@nibb.ac.jp">쒼l</a>
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̈Zr[, <strong>4</strong>, e006 (2015)@<a href="http://dx.doi.org/10.7875/leading.author.4.e006">DOI: 10.7875/leading.author.4.e006</a>
Makoto Suzuki & Naoto Ueno: <strong>Cell movement and polarity required for animal development.</strong>

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<h2>v </h2>
@̌`Ԍ`ɂčזËړȂǑgD3fO͕K{łD̉ߒɂāCזE͂ǂ̂悤Ɍ`Ԃ@\̔Ώ̐lzû낤DזE̕ƌX̍זẼ_Ci~bNȈړ邢͕ό`ƂȂgD̃fOƂɋ邱Ƃ`Ԍ`̌łDזȄWcIȈړό`Ƃꂽ^̂߂ɂ́Cǖʂł͋łȍזEڒC܂ʂ̋ǖʂł͌サ_ȉ^\ɂ邱ƂKvɂȂDזȄWc͍זEOVOiɂړmCזE͂ɂړ̑ǂƂDX̉^͍זEOVOiɈˑCזEǂ̖ȘAgێĂCɂ荂xɋזE^𐧌䂵ĂD܂ɁCזEЉ`ÂȂƂĂ̂D̃r[ł́CM҂̌܂߂ŋ߂̒mЉȂC`Ԍ`̉ߒǂ̂悤ɕqxŐ䂳Ă̂ɂĉD

<h2>͂߂</h2>
@ЂƂ̎󐸗͍זEԂɂȂĈ̂CɌŗĽ`ԂlD̔̉ߒɂāC͑\銲זEC܂܂ȐꉻזEւƕDCזE͂̕Â̊ՂɂĂČ͂ɂ͂Ȃ肦ȂDזEX邢͏WcƂẲ^ɂ萶̂ł̂DזEWc̋^ɂCgD͒PȃV[g\ǂЂȂǕGȍ\𐶂݂D̃r[ł́Č`Ԍ`זE^₻̔wiɂזEɐɊւŋ߂̒mCM҂̌ʂ܂߉D

<h2>1Ď`ƑO㎲̋ɐ</h2>
@̔ɂĐÂ傫ȌۂƂČ̌`Ď`̓EjȂǞ瓮Ғœ܂ŐiIɕۑꂽ{IȌۂŁCזËꕔij̓ւƗꍞނ悤Ɋד邱Ƃɂoij`ƂCɃ_Ci~bNȍזE^łD̂ƂC̕\wɂĂ͊OtזȆŜɂԂ悤ȉ^iGs{[^jNDނ̃fłAtJcKǴC̑傫ia͖1.2 mmj炱̌`̋@\̌ɏdpĂDAtJcKG̏ꍇC10̍זEւčזE1000ɂȂƂC̔wזEד͂߂D̂̂CזE͏̓iOjɂނĈړCɁC炨悤ɐ獶EɂނčLi<a href="#F1">}1a</a>jD̉^ɂCt̕Ct̔wCOt̕\wɔzu邱ƂC̍זE^͂̂̊튯`ɂ߂ďdvȈӖƂD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@̌`ɂWcIȍזE^ƍזEɐ̌`</strong>
iajAtJcKGɂ錴̌`̉ߒifʐ}jDt͐[tɂЂÂ̓Ɋדҍ`D͑gD̑ΓIȈړ̕D
ibj[t͊Oť`tBulN`wWcIɑOɈړDɂCtɈ͂D
icjʂƐLɂ钆t̍זE̋ɐщ^DPȌ`ԂזEʓזEɐVOiɂזEɐlO㎲Ɛ̕ɖa`ɕωDגȂזE̗[ɍזEˋN`CאڂזE悤ɉ^O̕ɑݓ荞݂ND
idjقȂgD̋EɂċNזE^Ƃ̐@\Dt̍זE͗אڂ̐ߍזE\זEƐڐGʒuɂނĔǂLD܂CזECa<sup>2+</sup>ZẍߓIȏ㏸ND
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/04/Ueno-4.e006-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2015/04/Ueno-4.e006-Fig.1.png&amp;caption=fig1-caption-text]

@̍זE^̌͂́CזȄWcOt̓OɂނĈړgWcIȍזËړhɂDM҂̍ŋ߂̌ɂC̈ړזEWc͈lɈړ͂𔭊Ă̂ł͂ȂC[̈ꕔ݂̂ړ\C̍זEWcĂ邱Ƃ킩Ăi<a href="#F1">}1b</a>jDזE͓ti@\IɕłȂtזEƒtזȄWcjƂ΂Čɂď̐ҍ̌`Ɋ^钆tזEƂ́C`q̈قȂ邱ƂmĂDti[Ɉʒu邱ƂC[tƂ΂j󂩂؏Ot̓̍זEOʂƂXChKX̂Ŕ|{<a href="#R1"><sup>1)</sup></a>Ct͑OɈړ邪Ctɂ͈ړ\ȂƂ킩D܂Ct̑gD̃[U[ؒfCt̍זEWcOɈړ̒t̍זEWc邱ƂɂCtł͑O̕Ɉ͂ĂitςĂjƂ炩ɂꂽ<a href="#R2"><sup>2)</sup></a>D
@̂悤ȍזEWc̈ړ͂ǂ̂悤ɋN̂낤DזËړɍזEOłtBulN`Kvł邱Ƃ͂łɂ킩ĂCtBulN`͈ړ̐͒SĂȂD|{זEgCזËړɂĂ͉wUƂȂ邱Ƃ킩ĂCwUm̕ֈړ鐫͑Ƃ΂D̔ɂWcIȍזËړɂĂCwU͕K{ł邱Ƃ炩ɂȂDƂɁČ`ɂẮCSDF-1PDGFƂ^pNwUƂđOւ̑gD̈ړ𑣐iĂDwU͊OtɂĔĂC̊̑jQ͓t̍זȆOւ̈ړjQ<a href="#R1"><sup>1)</sup></a>D܂ʂ̗ƂāC[utBbV̑j[Dj[̑OזE͎ӂ̑gDɂĔSDF-1̔ZxɈˑ̌ւƈړ<a href="#R3"><sup>3)</sup></a>D̂ƂCړזEWc͂܂Č`ꂽSDF-1̔Zxzɂ킦CêSDF-1̓ւ̈ڍsɂǏIȊzȌ`Cɂړ邱ƂCŋ߂̌ɂ薾炩ɂꂽ<a href="#R4"><sup>4)</sup></a>DȂ킿C牻wU̔ZxzmזECǂ̕Ɉړׂ肵Ă̂ƍlĎ`̍ہCt̍זE̓|fBAiˋNjOɂނɐL΂ĂC̃|fBA𑫂ɑOւƈړD܂CwU̔Zx̍قɃ|fBA`ƂΏ݂̐ĂDwU̔ZxzזEmזEɐɕϊ邵݂́Ĉ܂܂ȉߒŗp鐶̐헪ƂĂ悢낤DړזE̓ł́CʏC|fBǍ`ɂᕪqG^pNłRac1Cdc42OŁCRhoAŊĂĈ悤Ȋ̔Ώ̐זËړ\ɂĂD

<h2>2Dҍ̌`ƓŐɐ</h2>
@t͂̂ɐҍ`Dҍ͐Ғœł͔̌ɏgDł邪C̏ɂẮCO㎲ƒ鎲i瑤ɂނł邽߁COƂԁj̕ɂx̕Ăҍ̑gDXɐɏW܂O̕ɍגȂ邱ƂɂO㎲̕ɐL΂CƂ̌`Ԍ`ɂďdvȖDt̑Oւ̈ړjQƂ̐ҍ̌`ُɂȂ邱ƂCM҂́Č`͐ҍ̌`ƘAĂ̂ƍlĂDҍgD͐ɏW܂CɑO㎲̕ɐLт^͐ҍgD̑Ŝ̕ό`ƂāgʂƐLhiconvergence and extensionjƂ΂D̑gD̕ό`͌X̍זE̕ό`ƂȂƂ悭mĂD̉^̉ߒł́Cҍ̍זE͏Xɖa`ɂȂĈ݂Ɋ荞ނ悤ɂčE̕΂߂邱Ƃώ@ĂD܂CזE`Ԃ̕ωƂƂɁCגȂזE̗[ɂ͍זEˋNi|fBAуtB|fBAj`邱ƂCזEǂזEˋNgČ݂Ɉ肠Ƃʂ̌͂ɂȂĂƂi<a href="#F1">}1c</a>jDCŋ߁CAN`OɂזEZk邱ƂɂאڂזEƂ񏥂ꂽ<a href="#R5"><sup>5)</sup></a>DɂĂCOɂזEɐgD̎ʂCāCɂLЂNƂɕςȂD
@זEɐ𐧌䂷邵݂ƂāCgʓזEɐhiplanar cell polarityFPCPjmĂ<a href="#R6"><sup>6)</sup></a>DʓזEɐ̓VEWEoG̕\ʂɐ鏬Ȗсiсj̐ނ╡\ê̔zu肷邵݂ƂČĂi<a href="#F2">}2a</a>jDVEWEoGɂ`wIȎ@p͓IȌɂCʓזEɐ̃VOi`Bn\鑽̃^pNĂC̐ŕۑꂽ^pNłFrizzlediFzjCStrabismus/Van GoghCFlamingoCזEɂDishevelledCPrickleCDiegoȂǂƑݍpCזE̒[ɐ̋ɐi<a href="#F2">}2b</a>jDҒœɂẮC͔ÓTIWntoĤЂƂŁCWnt5Wnt11Ȃǂ̃KhƂȂ邱ƂmĂDM҂́CʓזEɐVOi^pNłGlypican4i[utBbVł́C<em>knypek</em>`qɃR[hjPrickleҒœɂĂ͌̌`ѐҍ̌`ɕK{ł邱Ƃ𖾂炩ɂ<a href="#R7"><sup>7,8)</sup></a>D܂C̒ḿCʓזEɐVOiĕۑĂCזE΂łȂtזE̊ȉ^ɂKvł邱ƂĂDʓזEɐ͌̌`邢͐ҍ̌`΂łȂC܂܂Ȋ튯̌`CƂɁCLƂȂ튯̌`ɗpĂDŋ߁CʓזEɐVOi^pNłVan Gogh-like 2iVangl2j̃mbNAEg}EX̕\^CVangl2l̐LɕKvł邱Ƃꂽ<a href="#R9"><sup>9)</sup></a>D̂悤ɁCgD̎ʂƐLɂ͓g܂킳Ă\D܂CזE̔Ώ̐𐶂ނƂVEWEoGт̌`ɂƓl̋@\́CҒœɂĂ炩ɂĂD̗LэזE͑gD̎ɂċKzuĂC̔̉ߒł͕ʓזEɐVOi^pNłFz3Vangl2זE̊̑ɋǍ݂邱ƂKvł<a href="#R10"><sup>10,11)</sup></a>DAǂ͐BŎYꂽqq{֗A邽ߋ@щ^Ƒ̃q_\`D̉ߒɂĂʓזEɐVOi^pN@\ĂCזE̊-[ɂċǍ݂Celsr1iFlamingȏ^pNjƑ@щ^ƃq_\sKɂȂ<a href="#R12"><sup>12)</sup></a>D܂C̏̃m[hî̕ڂ񂾑gDjɂẮCm[hזE̕\w1@тזĚɈʒǔɂނĉ]^邱Ƃ̍ĚɕKvł邪C̉ߒɕʓזEɐVOi^pN̑O㎲ɂΏ̂ȋǍ݂K{ł邱Ƃ炩ɂĂ<a href="#R11"><sup>11,13)</sup></a>D

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@VEWEoG̏ɂ镽ʓזEɐVOi</strong>
iajmꂽʓזEɐVOi͏т̐ʒuʑɒ߂D̋@\̑ŜŋNCɂт̂ނ낤D
ibjזEɂ镽ʓזEɐVOi^pN̋Ǎ݁DFrizzlediFzj͉ʑCStrabismus/Van GoghiVangj͋߈ʑCFlamingoiFmij͉ʑƋ߈ʑ̗̒[ɋǍ݂DזEɂẮCDishevellediDshjDiegoiDgoj͉ʑCPrickleiPkj͋߈ʑɂĖ^pNƑݍpDݗ}@\Ȃǂߎɂ^pN̕zɋɐD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/04/Ueno-4.e006-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2015/04/Ueno-4.e006-Fig.2.png&amp;caption=fig2-caption-text]

@M҂́CʂƐL̐@\T邽߁C@\IȍזEɐ̌`̎wWƂĔǂ̓Ԃώ@DEB1EB3͔ǂ̃vX[iL[jɌ鐫DāCEB1邢EB3GFPƂ̗Z^pNɂĂ̓Ԃώ@Ɣǂ̐L̋ɐm邱ƂłDזEC[WOɂώ@̌ʁCǂ͐ҍƂ̑Ɉʒu̐߁i͋ؓɂȂjƂ̋EɂނĐL邱Ƃ킩<a href="#R14"><sup>14)</sup></a>i<a href="#F1">}1d</a>jD̐ҍƑ̐߂ƂقȂgD̋E̐ҍɂẮCזECa<sup>2+</sup>Zx̕pɂȏ㏸݂ꂽDقȂgD̐ڐG|{ɂĂlCa<sup>2+</sup>Zx̏㏸ώ@C̑gD̐ڐG|{ł͂̕px͒ႢƂCҍƑ̐߂Ƃَ̑gD̂̋ECa<sup>2+</sup>Zx̏㏸̈ɂȂȂ炩̏Ƃ\z<a href="#R15"><sup>15)</sup></a>D

<h2>3D_oǂ̌`ƒɐ</h2>
@_oǂ͊Ot_ôɐ݂钆_oňŁCOł͔]C̊ł͐Ґ`D_oǂ͗ނƗrނƂŋʂIȊǌ`̉ߒւ邱ƂmĂi<a href="#F3">}3a</a>jD_oǂ͊OtU_oƐ_oƂ΂V[g̑gDɕωĈ̂C_oOtƂ̋EɑO㎲ɂĐ_oƂ΂闲N`D̐_o̒ɂĐ_oȂ邱ƂɂC_o̒[ɂėZC_o̃V[g\ǂ`邱Ƃ킩ĂD̊ǌ`jQ_oǕsS̓qgɂ2000`3000̏oY1̊ł݂񕪐Ғŏǂ̌łC`IȔwi邢͊vɂ񕪐Ғŏǂ̕ả𖾁CƂɁCזExł̕aԂ̉𖾂͈wɂďdvȌۑ̂ЂƂłD̐_oǂ̌`ɂזEό`̋@\̉𖾂ɂẮĈ̊OŔѐ_oǂ̌`ώ@邱Ƃ̂łAtJcKGjg󂪑傫vĂD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@_oǕɂזE^</strong>
iajAtJcKGɂ_oǂ̌`̉ߒifʐ}jĎ`̂̂ɔwɌ`ꂽ_oOti_oj̑ɂ1΂̃q_\i_oj`Ĉɐ_oa`D_o̒[ǂwŗZǍ\i_oǁj`D
ibj_oזE̒ɐɂזĚ`Ԍ`Ɣ_oOtɂgD񎩗Iȋ@\Dɐ_oזÉCǂ̍pɂ蒸̕ɐL̂C1jANg~IV̊ɂ蒸[kD܂CgD񎩗Iȉ^ƂāC2j_oOẗړɂ鈳kD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/04/Ueno-4.e006-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2015/04/Ueno-4.e006-Fig.3.png&amp;caption=fig3-caption-text]

@܂ł̌ɂĂƂڂĂ̂́C_o̓ŋN`Ԍ`łi<a href="#F3">}3b</a>jD_o͏\ƂC̊O[CꑤƂmȒɐD[ɂ͋łȃ^CgAhwX`OẺt̂̐NӂC܂CזEV[gƂĂ̓ێĂD_o̋ȂɂזE͂̒ɐɂčזELђ[kƂ2̑傫ȕωNČʂƂāCь`̌`Ԃւƕω邱Ƃ킩ĂDqW|CgƂ΂̈悪擱Ă̍זE̕ό`NƂgD̋Ȃ̌͂ƍlĂDM҂̍ŋ߂̌ɂCꎲ̕ւ̍זELɂĂ͔ǂ̐Ldvł邱Ƃ킩ĂD_oǂ̋ȕ̍זE̔ǂώ@ƁC[}CiX[CꑤvX[ƂĔzĂD̔ǂ̐L𐧌䂵_oǂ̌`ɂ^pNTƂCMID1MID2Ƃ΂qgOpitzǌQiCCCAȂǂ̏\̓Ɉُ킪݂ǰ`qɃR[h^pNCǂɌזĚ`ԕω𑣐iĂ邱Ƃo<a href="#R16"><sup>16)</sup></a>D̈`q̋@\jQƁC_oɂđgD̋ȂɂזĚ`ԕωjQꂽD艻ǂ̃}[J[łAZ``[uƉuFƂCMID1MID2ɂǂ̈艻ቺĂCɂ葩jQꂽƂōזEL}ꂽ̂ƍlꂽDזELɂÂċN钸[ḱC[ɏWςANg~IVn̊ɂND񂿂Ⴍfipurse-string modeljƂ΂悤ɁC[ɂăAN`̂ЂזEڂ悤ɕό`邽߁CזE͌ʂƂĂь`ɂȂD̃ANg~IVn̐ɂ͑̃^pNĂCÓTIWntoHAN`^pNShroom3ȂǂRhoÅ~IṼ_̑iɋ@\邱Ƃ킩Ă<a href="#R17"><sup>17)</sup></a>D܂CזEڒ[kWcIȍזE̕ό`ɂďdvł邱Ƃ킩ĂCJhwlN`ȂǍזEڒq̋@\炩ɂĂ<a href="#R17"><sup>17,18)</sup></a>DזEڒq̖́CgDƂĂ̓ێ΂łȂCזE^̋N_ƂȂړCkCLWȂǍזE̕IȕωזEڒĎ͂̍זEɓ`B邱Ƃɂ̂낤D
@̂ΑgDIȉ^ɑ΂CM҂́CSȐ_oǕɂ͑gD񎩗Iȉ^Kvł邱Ƃoi<a href="#F3">}3b</a>jD_oǂ̂̂͐_o炩番C[k̏dvȌ͂ɂȂĂ邪C̊ǌ`ɂ͔_o^Ă邱Ƃ킩Ă̂<a href="#R19"><sup>19)</sup></a>D_oOt̊^ɂẮC[̕\ʂ̐LWCO㎲ɂזECʂƐLɂgDfOC̓w\wɂނiˁj̍זÊׂ荞݁CȂǂǌ`𑣐iƂ̉\񏥂ĂCM҂̎ъώ@ł́C̉\x錋ʂȂDCfW^XLV[gidigital scanned light-sheet microscopeFDSLMjpזEC[WOώ@ɂC_oזȆO[璆ɂނđ傫ړĂC̈ړ͒ōɔwւƂނĂ邱Ƃ킩DɁCwɂނזE͈lɂ̕\wwɂĐLĂD̍זEWc̈ړ_oǕɊ^Ă̂ƍlCɏڍׂɊώ@D_oOt͕\wƐ[wƂɕ邱ƂłD\w̍זE͓T^Iȏl̑gD`CJhwȂǂłȍזEڒɂgDƂĂ̈萫ѓێĂ̂ɑ΂C[w̍זE͍זEڒキCtזÊ悤ɌX̍זE`ōזEˋNLȂwւƐϋɓIɈړĂ邱Ƃ킩D̐[w̍זE^\w̏זEĂ̂Ɨ\zC[U[ɂgDؒfsDؒfgD̔͂̂ĂƂCؒfʂ͔w̕ɔ傫J邱Ƃ킩D܂CCeÕmbN_Eɂ[w̍זE̔wւ̈ړjQƐؒf̂̂̔͏ȂC܂C_oǕsSЂNDȂ킿C[w̍זEƕ\w̍זEƂ̂ɂ͎アזEڒiĆjC[w̍זE̊Ȉړ_o̔wւ̈ړ擱_o𑣐iĂ̂ƌ_Â<a href="#R19"><sup>19)</sup></a>D̂ƂCSȐ_oǕ͒[kƂgDIȋ@\Ɣ_oOẗړɂgD񎩗Iȋ@\̗҂ɂ芮邱Ƃ炩ɂꂽD

<h2>4D_oזËړƍזEɐ</h2>
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<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/04/Ueno-4.e006-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2015/04/Ueno-4.e006-Fig.4.png&amp;caption=fig4-caption-text]

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<h2></h2>
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<h2> </h2>
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</ol>
<div class="au-profile">
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<span class="author">  iMakoto Suzukij</span>
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<strong> liNaoto Uenoj</strong>
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</div>
? 2015  E쒼l Licensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
