Aɂ`q`̐ip^[

<strong> </strong>
iw@w擱Ȋw ̐iwUj
emailF<a href="mailto:takuno_shohei@soken.ac.jp">쏫</a>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
̈Zr[, <strong>5</strong>, e009 (2016)@<a href="http://dx.doi.org/10.7875/leading.author.5.e009">DOI: 10.7875/leading.author.5.e009</a>
Shohei Takuno: <strong>The evolutionary patterns of gene body methylation in plants.</strong>

<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/10/Takuno-5.e009-PDF.pdf" target="_blank"><img class="size-full wp-image-112 alignright" title="Download PDF" src="/images/downloadPDF.png" alt="Download PDF" width="100" height="20" /></a>
<p>
<p>
<p>
<p>
<p>
<!--more-->

<h2>v </h2>
@̃QmɂDNÄꕔ̃VgV̓`ĂDDNA`ƂDAɂĂCGẑقCHGz񂨂CHHz̃VgVɃ`݂DʂɁCCGzCHGz񂨂CHHz̗DNA`ĂꍇCDNA`͈`qgX|]̔}ɂ͂炭DC`q̓ɂẮCقCGẑ݂DNA`݂DDNA``q`ƂсCA܂ޑ̐ɂ݂D`q`͔}CނCʂ̑`qɂ݂XɂD܂ł̌ɂ`q`̋@\Ɋւ邢̉񏥂ꂽCƂɋ@\ȂƂ\Sɂ͔ے肳ĂȂD̃r[ɂẮCM҂炨тق̌O[vɂAɂ`q`̐iwIȌЉC`q`̐wIѐiIȈӋ`ɂčl@D

<h2>͂߂</h2>
@V[NGT[̔Bɂ肳܂܂Ȑ̑SQmz̉ǂeՂɂȂDɂƂȂCDNA`qXg̏Cɑ\GsWFleBbNȏC̃Qm̑Ŝɂp^[̉𖾂eՂɂȂDGsWFleBbNȏC̃Qm̑Ŝɂp^[Qmɑ΂GsQmƂԁDQmǐ̗j͔ɒCi̗_ĂDCGsQm̐iwIȌ͂͂܂΂łD̃r[ł́C܂Qm̐i̗_ɂĉC̗_GsQm̐iɓKł邩ɂċc_D

<h2>1DQmi̗_</h2>
@Qm͐̐炵߂̂ɕK{Ȉ`łC̎̂̓AfjC`~COAjCVgV4ނ̉DNAłDDNAzɂ͈`qƂ΂@\Pʂ݂C݌v}ƂĐ^pN̂ɂĂ܂܂ȖSÂDQm͔ɏdvȂ̂ł邪Csςł͂ȂDQm͓ˑRψقɂ莞ԂƂƂɕωĂDꂪ̐ǐ͂ƂȂD
@̐ilƂCڂ1݂̂̂l邾ł͕s\łC̎ɑC݂Ɍz\ŁCɁČׂĂ̌̂lKvĎ̂̏W܂WcƂсCWcx̐if`̖@ɏČ镪Wc`wƂ<a href="#R1"><sup>1)</sup></a>D͎Ԃo߂Ǝɂ莀ɐ₦邽߁CLBȂǂɂ莟`KvDWcɊ܂܂̂ǂzČオ̏Wc`D̉ߒԂďWc͈ێD
@̉ߒɂēˑRψقDWc`wɂẮC̓ˑRψق̏WcɂpxiΗ`q̕pxjɒڂDˑRψ͔ٗɒႢ߁CWcɊ܂܂ق̌̂łɓˑRψقm͖łقǒႢD܂C2{̂̐ɂāC1͖̂쐶^ƓˑRψٌ^Ƃ̃weڍ̂ɂȂĂDWcɑ݂̂̐<em>N</em>ƂƂCΗ`q̕px̏l1/2<em>N</em>ɂȂD啔̓ˑRψق͐̕\^ɂ͉eȂƍl邽߁C̂̂̌z̓_ɋNĎʁCł̑Η`q̕px͊SɋRɂ茈肷Ďʂ`IƂi<a href="#F1">}1a</a>jD啔̓ˑRψق͎ɂ͎󂯌pꂸCWcDC̕pxRɏ㏸ÂCŏIIɑΗ`q̕px1ɂȂ邱ƂD܂CׂĂ̌̂̓ˑRψقzڍ̂ƂĂ悤ɂȂĎۂˑRψق̌ŒƂԁD̂悤ɁCQm͈`IƂŘʂłiD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@Η`q̕px̕ω</strong>
ΐF̖́CVȓˑRψق̂̃Qm̂镔ʂɂĐƂDԐF̖́C̓ˑRψقWcɌŒ肳ꂽƂD
iajKxɉeȂiIIɒłjˑRψق̏ꍇD
ibjɗLȉeڂˑRψق̏ꍇD
icjɕsȉeڂˑRψق̏ꍇD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/10/Takuno-5.e009-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2016/10/Takuno-5.e009-Fig.1.png&amp;caption=fig1-caption-text]

@C܂ɓˑRψق\^ɉeڂꍇDˑRψٌ^쐶^ɔאɐBɗLȉeڂꍇlD쐶^ƔׂƂ̌̎c₷KxƂсCˑRψقɂe̂̓Kx쐶^̓Kx܂ƁCΗ`q̕px͋}ɏ㏸Œ肳i<a href="#F1">}1b</a>jD̑Η`q̕px㏸͂𐳂̎RIƂԁDCLȓˑRψقׂ̂ĂWcɌŒ肳킯ł͂ȂCWĉ݂D́C̎RI̗͂`I̗͂ɕ邱ƂXɂĂ邩łDtɁCˑRψق̉e̂̓Kx쐶^̓Kx܂ƂCΗ`q̕px͋}ɒቺXɂi<a href="#F1">}1c</a>jD̗͂𕉂̎RIƂԁD̎RȈꍇƓlɁC`I̗͖͂łȂCɂ܂ł͂邪CLQȓˑRψقWcɌŒ肳邱ƂĎۂ͏Wc̑傫قǂ悭ND́C`I̗͂͏Wc̑傫قǑ傫łD܂Ƃ߂ƁCQḿC悢ˑRψقɎcCˑRψق؂̂ĂĐiXɂ邪CŘʂ傫Ȗ͂D

<h2>2DGsWFleBNX̊b</h2>
@QmƂ͊ȒPɂƐɌŗL̐݌v}łD̂\邷ׂĂ̍זẼQmDC̂ɂĂCႤgD̍זEKvƂ`q̃Zbg͈قȂDƂ΁CA̗tł΂ǂ̍זEɂĂtɕKvȈ`񂪔CԂł͂܂`񂪓K؂ɔ悤vOĂD܂C̂̔iނƂɓK؂Ȉ`q̔I邢̓ItKvCQmȂDNAzȊȌɂ`̔͐䂳DDNAzȊȌɂ`q̐͐ۂɐ[ĂĈ悤DNAz̕ωƂȂȂCזÊ̂ɂp`q̕ω镪̓GsWFleBNXƂ΂D
@̈`q𐧌䂷@\ƂăGsWFleBbNȏC悭ĂD1ڂ̓qXg̏CłDDNA͂ނ̂܂܍זEɑ݂̂ł͂ȂCqXg^pNDNAƂ̂̕łN}`Ƃđ݂CɁC炪ÏWF̂`DqXg4ނ̃qXg^pN2Ȃ锪ʑ̂`邪CqXgɉwIȏCt^邱ƂqXg̏CƂԁDƂ΁CqXgH39Ԗڂ̃A~m_łLys`ƁC̎ӂ̃N}`͋ÏWăweN}`ƂȂ蔭͗}DCqXgH34ԖڂLys̃`͔̊ƋւD
@2ڂDNA`łD̃r[ɂẮCƂɐ^jɂVgṼ`ɏœ_ĂDDNÂ4ނ̉̂CVgV̘Z5ʂ̒YfqɃ`t^DQmɂĂׂẴVgV`킯ł͂ȂDɂẮC{IɃVgV̂ɃOAjÂCGz̃VgV`ꂤDCGzDNA`CG`ƂԁDCAɂĂׂ͂ẴVgV`ꂤ邪C̔zɂقȂ郁`̋@\pDAɂDNA`ɂCG`CCHG`CCHH`3ނCH̓OAjȊỎDDNA`́CqXgH39ԖڂLys̃`ƓlɁC}ɂ͂炭ƍlĂD
@DNA`͍זÊ̂ɂp<a href="#R2"><sup>2)</sup></a>DDNA͓d点\ƂCZX5f-CG-3f̂ƂA`ZX3f-GC-5fƂ񕶍\ɂȂD{IɁCZX̃VgV`ĂƂCA`ZX̃VgVɍmŃ`ĂDCזEɂƂȂDNA̍ۂɐVɍ閺DNA̓`ĂȂD܂C񕶍\̕Е̃VgV`ĂȂDw~`ԂƂD̃w~`ԂFCDNÃVgVVɃ`čזÊ̂CGzDNA`ێ@\݂D̋@\̒jƂāCłDNMT1CAłMET1ƂDNA`yf肳ĂD܂CAɂCMT3ƂNhCDNA`yf݂DCMT3CHG`̈ێ̒jƂĂ͂炫CCHG`ƃqXgH39ԖڂLys̃`ɑ݂Ɉˑ鎩ȋ[vɂ芈<a href="#R3"><sup>3)</sup></a>DCCHH`ɂĂ͍זE􂲂ƂRNAˑ^DNA`̋@\͂炭<a href="#R2"><sup>2)</sup></a>D̂悤ȋ@\ɂDNA`͍זÊ̂ɂێD

<h2>3DQmƃGsQm̊֌W</h2>
@ߔNDNAV[NGT[̔BɂC̐ɂđSQmz񂪉ǂĂDɂƂȂCQm̑ŜɂăGsWFleBbNȏCǂ̂悤ɕz邩͂悤ɂȂD̃GsWFleBbNȏC̃p^[Qmɑ΂GsQmƂԁD܂܂ȐgDɂăGsQm̉ǂ}ɐiłČ̕̂ɂăGsQmǂ錤łD
@AɂDNA`̓QmɃ_ɂ͕zȂDDNA`̃p^[́CQmɂ`q̖xуgX|]̖xƖڂɃNDClȐA<em>Brachypodium distachyon</em>̑SQmɂāCQm̗̈̂DNA`̃xC܂C`ꂽVgV̊ɂ͑傫Ȃ΂<a href="#R4"><sup>4)</sup></a>i<a href="#F2">}2a</a>jDDNA`̃x́CF̂ɂgX|]̖xƐ̑ցC`q̖xƕ̑ւDgX|]̓ɂẮCCG`CHG`̃xۗči<a href="#F2">}2b</a>jDCG`CHG`ƁCCHG`ƋւqXgH39ԖڂLys̃`gX|]̈ɂweN}`̌`ɏdvłƍlĂC̐AɂẴp^[݂<a href="#R5"><sup>5)</sup></a>D܂Cv[^[̈ɂĂDNA`̃xɒႢi<a href="#F2">}2c</a>jD́C`q̔}Ȃ߂ƍlD`qR[ḧɂĂ͈`qԗ̈荂xCG`݂邪CCHG`CHH`̃x͒Ⴂi<a href="#F2">}2c</a>jD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@<em>Brachypodium distachyon</em>̃QmɂDNA`̃p^[</strong>
iaj1F̂ɂDNA`̃p^[CgX|\̖xC`q̖xD
ibjgX|]DNA`̃p^[D0̓gX|]̋EC̓gX|]̖{̂D
icj`qDNA`̃p^[D0͓]ʊJn_CE0͓]ʏI_D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/10/Takuno-5.e009-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2016/10/Takuno-5.e009-Fig.2.png&amp;caption=fig2-caption-text]

@̂悤ɁCGsQm̍\̓Qm̍\ƖڂɊ֘AD̐AɂĂl̃p^[݂<a href="#R5"><sup>5-7)</sup></a>DCQmɑ傫ȕωNꍇCGsQmɂeƗ\zDtɁCGsQm̃p^[Qm̍\ɉeڂƂD`ꂽVgV͓ˑRψٗɍȂC`~ɕω₷ȂDہCCG`݂݂̂Ä`qɂẮCCGz̐`qGCܗʂ҂LӂɏȂ<a href="#R8"><sup>8)</sup></a>D܂CQm̐iƃGsQm̐i͋֘AD

<h2>4DAɂ`q``q̓</h2>
@`qR[ḧɂCG`͈`q`igene body methylationjƂ΂DʂɁCQm̐iۂɂ͂܂܂Ȏ̂ŃQmrDCÂɕ̂̃Qm̔ŕC`qR[ḧ̂قł͍łD̂߁CGsQmi̗ƂĈ`q`ɒڂD
@`q`ȊODNA`͈`qgX|]̗̔}ɂ͂炭ƍlĂDC`q`̋@\͂܂słD`q`̃x͈`q̂ő傫Ȃ΂<a href="#R5"><sup>5)</sup></a>DCGzɂ`q`͔ʂ̍`qɂ݂Xɂ邽߁CȂƂ̗}ɂ͂ȂƎv<a href="#R8"><sup>8,9)</sup></a>D
@܂łɁC`q`̋@\ɊւĂ܂܂ȉ񏥂Ă<a href="#R10"><sup>10-12)</sup></a>DƂ΁C1j`q̓ɂqXgH2A.Z̒~ς}C2j`q̓ɑ݂v[^[̔}C3jCg̃XvCVOɂC4j]ʂ̌グC5j]ʗʂ̃mCYCȂǂ񏥂ĂDC܂̂ƂCǂ̉ߎɌD
@ۂ̂ƂCVCkiYiق̐AɂāC`q`̓_ɑ݂킯ł͂Ȃ<a href="#R8"><sup>8,13)</sup></a>Dɂqׂ悤ɁC`q`͔ʂ̍`qɂ݂D1j̃qXgH2A.Z͑gD邢͊ɓٓIɔ`qɂ悭݂DۂɁCgD̑`qقǈ`q`݂XɂDЂƂdvȓ_ƂāC`q̒D`qقǈ`q`\XɂD`qɂẮC2j̕svȃv[^[mオDӂ߁C`qɂ͈`q`݂̂ȂDɁC`qقǃGL\̐Ɗ҂Ĉ悤Ȉ`qɂẮC3j̃XvCVŐ@\dvɂȂ肤DہCfAłVCkiYi͂߁CAɂĈ`q̒ƃGL\͍̐̑ւD܂C`q`͂܂Œ񏥂Ă悤ȋ@\̉ۂɊ҂`qɂĂ݂Xɂ悤ɂ݂D

<h2>5D`q`̐iIȕۑ</h2>
@̂ǂꂩ̉邢͕̉ꍇC`q`͏dvȋ@\ƂɂȂDꂪDNA`ł͂ȂDNAz̏ꍇɂ͋c_͊ȒPɂȂDDNAẑ̈悪ɏdvłꍇC܂܂Ȏ̂łDNAzrƂCق̗̈ۑĂ邱Ƃ҂D́CDNAz񂪕ωȂ̂ł͂ȂDDNAz͈̑xŕωDC̕ω̂̓KxቺƁČ̂͌cɂȂD܂C̕ω͕̎RIɂ莟ɓ`炸i<a href="#F1">}1c</a>jĎʁCDNAẑŔrƂCdvDNAzɂĕω͋NĂȂ悤ɂ݂D
@M҂́C̗_DNA`CƂɁC`q`ɉpł邩ǂ𒲂ׂ邽߁CClƂ̋߉ł<em>B</em>. <em>distachyon</em>̑SQmɂDNA`̃p^[rD̂őcʂƂ`q̃yAI[\OƂԂCCl<em>B</em>. <em>distachyon</em>̃I[\ÔłCG`̃xĂLӂȐ̑ւ<a href="#R4"><sup>4)</sup></a>i<a href="#F3">}3</a>jD܂CClɂĂ`q`q`ꍇC<em>B</em>. <em>distachyon</em>̃I[\OɂĂxDNA`݂ꂽD̂悤ȌX͂܂܂ȐAɂĒׂCAuiȂ̃VCkiYi<em>Arabidopsis lyrata</em>CɁC̋߉<em>Capsella rubelle</em>ɂĂ݂ꂽ<a href="#R14"><sup>14)</sup></a>DqACqACV_A݂ꍇɂľX݂CŒ4ÑXpň`q`͕ۑĂ邱Ƃꂽ<a href="#R5"><sup>5)</sup></a>D̂ƂC`q`͏dvł\ꂽD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@Cl<em>Brachypodium distachyon</em>̃I[\OɂCG`̃x̕ۑ</strong>
_̓Cl<em>B</em>. <em>distachyon</em>Ƃ̂̃I[\OD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/10/Takuno-5.e009-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2016/10/Takuno-5.e009-Fig.3.png&amp;caption=fig3-caption-text]


<h2>6DqAɂ`q`̐ip^[</h2>
@C݁CƂm炵Ƃ`q`̋@\̉́C`q̃weN}`}YłƂ̂ł<a href="#R3"><sup>3)</sup></a>DVCkiYiɂĂ͐̈`qweN}`̕WIɂȂD܂CCG`CCHG`CqXgH39ԖڂLys̃`~ςC̈`q̔}D̃weN}`ɂCHG`̈ێɂCMT3dvłƍlĂDCVCkiYiɑ݂IBM1̓weN}`̕WIƂȂ`qCHG`уqXgH39ԖڂLys̃`C`q̃weN}`ӂȔ𑣐iĎʁC`q̓ɂCG`݂̂cD܂CVCkiYiɂĈ`q`͂Ƃɋ@\Ȃ\D
@x錋ʂƂāC`q`ȂVCkiYi̋߉킪ꂽ<a href="#R15"><sup>15)</sup></a>DAuiȐAł<em>Eutrema salsugineum</em><em>Conringia planisiliqua</em>ɂāCQm<em>CMT3</em>`qĂDɂƂȂC炭`qweN}`ȂȂC̕Ył`q̓CG`݂ȂȂƗ\zD
@̌ʂ́C`q`iIɍxɕۑĂdvłƂʂƖ悤ɂ݂DCɏqׂ悤ɁCỉߒɂĂ͂܂ɐɐBɕsȉe炷ˑRψقŒ肳邱Ƃi<a href="#F1">}1c</a>jD́CɂˑRψق̕px̓Ԃ͋Rɂʂ傫߂łCWc̑傫قǂ̋Řʂ͂炫₷ȂD܂C̎RIɂˑRψق̕px͒ቺɂނƂ邪CRɕpx㏸WcɌŒ肳m̓[ł͂ȂD<em>E</em>. <em>salsugineum</em><em>C</em>. <em>planisiliqua</em>ɂ<em>CMT3</em>`qш`q`ĂƂʂ炢邱Ƃ́C`q`͐ɂ͕KK{ł͂ȂCƂƂłD
@̂̂ɂ݂DNA`̃ẍقȂ̈DMRidifferentially methylated regionC`ϗ̈jƂDDMR͂Sbpƈ`q̑SƔהɒZC`q̓ɑ݂DVCkiYi100̈ȏ̑SQmz񂨂ёSQmɂDNA`̃p^[͂<a href="#R16"><sup>16,17)</sup></a>CDMRCG`̃x̍̂ɂĈ`q̔ʂɂ͂炭XɂD܂C`q`̋@\̗L͂ƂC̕ω`qɂȂ炩̉eڂƂ͊m炵D܂CDMRɂ`q̏㏸XEF[fk̃VCkiYȉWcC܂Cnւ̓KɊ֗^\ꂽ<a href="#R17"><sup>17)</sup></a>ĎʂCDNAz̕ωłȂCDNA`̕ωɂ̎RI͂炭\D
@VCkiYǐ̂̂ɂ݂ψق́C70N100N̂ɒ~ςꂽ̂łD̐il邤ł͔ɒZԂɁCSbpƂZ̈ɂDNA`̃ẍႢ~ςꂽDŁĈň`q`̃xrƂɂ͕ۑĂXɂƂCDMR̂悤ȏȕω͌ǂ͏Ɨ\zDCƒi̎ԂlƂCȕω̒~ςɂ`q`̃x傫ω\͔ےłȂ낤D
@܂Ƃ߂ƁC`q`͐A̐ɕK{ł͂ȂDC`q`̃x̕ω͈`q̔ɑȂ菬ȂeڂDDNAz̕ωƔׂāCDNA`̕ω`q̔ɂڂe͏ƂVCkiYiɂĎĂ<a href="#R18"><sup>18)</sup></a>DCɂ킽ilƂC`q`̕ω̒~ς͈`q̔ь̂̓Kxɉe\D

<h2>7DAɂ`q`̐ip^[</h2>
@`q`͂܂܂Ȑɑ݂CҒœCҒœCAɂ݂<a href="#R9"><sup>9)</sup></a>DCsɂāCÃRPAɂĈ`q`݂͂Ȃ<a href="#R7"><sup>7)</sup></a>DM҂́CA̗jɂĈ`q`ǂ̂悤ɐiĂ𖾂炩ɂ邽߁CJĂ5̗ȂSQmɂDNA`̃f[^CсCVɓ9̗AɂDNA`̃f[^͂<a href="#R5"><sup>5)</sup></a>D̃f[^́CRPA3CV_A2CqA3CqA6܂ށi<a href="#F4">}4</a>jD̎ɂĂ͑SQmz񂪉ǂĂȂEST̃f[^pD̂߁CGL\ɂDNA`̃p^[ɏœ_ĂD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@A14̌n֌WуGL\ɂDNA`̃x</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/10/Takuno-5.e009-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2016/10/Takuno-5.e009-Fig.4.png&amp;caption=fig4-caption-text]

@̗̂̂ÃGL\ɂDNA`̕ς̃xɂ͑傫Ȃ΂i<a href="#F4">}4</a>jDRPނɂĂCG`CCHG`CCHH`ׂ̂ĂɒႢlDCV_A͍CG`̃xDqACG`̃xClɁCCHG`݂CVCkiYǐʂƂ͑傫قȂDqAɂẮCCG`̃xɂ͂΂͂̂́CCHG`CHH`̃x͒ႢXɂDɁCSQmz񂪉ǂĂɂāC`qDNA`̃p^[𒲂ׂƂDv[^[̈ɂDNA`啝Ɍ_ƁC`q̒ɂقDNA`̃xȂ_͋ʂłi<a href="#F5">}5a</a>jDC_DCG`̃x̐Βl͎ɂ傫قȂDɁCe[_}cł͈`q̓ɂčCHG`݂ꂽĎX͗qAɓٓIƂ킯ł͂ȂCgERVɂĂʂĂi<a href="#F5">}5a</a>jD

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@Aɂ`q`</strong>
iajVCkiYiCe[_}cCgERVɂ`qDNA`̃p^[D0͓]ʊJn_CȆ0͓]ʏI_D
ibjA14ɂQm̑傫ƃGL\ɂDNA`̃xƂ̊֌WD_͗A14킻ꂼD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/10/Takuno-5.e009-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2016/10/Takuno-5.e009-Fig.5.png&amp;caption=fig5-caption-text]

@ǂ̂悤ȗv`q̓ɂDNA`̃x肷ׂ̂<a href="#R5"><sup>5)</sup></a>DAɂăQm̑傫ɂ͔ɑ傫Ȃ΂CQm傫ɂĂ̓gX|]Ȃǂ̔z񂪑啔߂<a href="#R19"><sup>19)</sup></a>DgX|]̈͊{IɃweN}`CDNA`̃xɍD̂߁CQm傫قDNA`̃xC`q̓ɂĂYIDNA`̃x㏸ĂƗ\zD̉؂邽߁C14̗Ä`qgX|]Ɨގ̂̂ƋU`q炵̂菜C`q`̃xƃQm̑傫Ƃ̊֌W͂ĎʁCCG`CHG`ɂėLӂȐ̑ւoC͎xꂽi<a href="#F5">}5b</a>jDƂɁCCHG`ƃQm̑傫Ƃ̑ւƂCQmYƂCHG`㏸ƍlꂽĎʂ́CAɂăQmiƁCGsQmɕtĐi邱ƂƂD

<h2></h2>
@GsQm̐ǐ͂͂܂΂łD݁CAɂĂ̓VCkiYǐƂiłCق̎̃f[^~ςDCGsQm̐ïʑmɂ́C葽̃QmуGsQm̃f[^KvɂȂDQm̐i̊b͏Wc`wɂ邱Ƃ͂̃r[̖`ɂďqׂDlɁC܂܂Ȏ̃GsQm̑^f[^̉͂̓GsQm̐i̖@̉𖾂ѐi̗_̍\zɏdvłC̔WɊ҂D

<h2> </h2>
<ol>
<li id="R1"><span class='au'>Crow, J. F. & Kimura, M.</span>: <span class="ti">An Introduction to Population Genetics Theory.</span> <span class='so'>Harper & Row, New York (1970)</span></li>
<li id="R2"><span class='au'>Matzke, M. A. & Mosher, R. A.</span>: <span class="ti">RNA-directed DNA methylation: an epigenetic pathway of increasing complexity.</span> <span class='so'>Nat. Rev. Genet., 15, 394-408 (2014)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/24805120" target="_blank">PubMed</a>]</span></li>
<li id="R3"><span class='au'>Saze, H. & Kakutani, T.</span>: <span class="ti">Differentiation of epigenetic modifications between transposons and genes.</span> <span class='so'>Curr. Opin. Plant Biol., 14, 81-87 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20869294" target="_blank">PubMed</a>]</span></li>
<li id="R4"><span class='au'>Takuno, S. & Gaut, B. S.</span>: <span class="ti">Gene body methylation is conserved between plant orthologs and is of evolutionary consequence.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 110, 1797-1802 (2013)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/23319627" target="_blank">PubMed</a>]</span></li>
<li id="R5"><span class='au'>Takuno, S., Ran, J. H. & Gaut, B. S.</span>: <span class="ti">Evolutionary patterns of genic DNA methylation vary across land plants.</span> <span class='so'>Nat. Plants, 2, 15222 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/27249194" target="_blank">PubMed</a>]</span></li>
<li id="R6"><span class='au'>Feng, S., Cokus, S. J., Zhang, X. et al.</span>: <span class="ti">Conservation and divergence of methylation patterning in plants and animals.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 107, 8689-8694 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20395551" target="_blank">PubMed</a>]</span></li>
<li id="R7"><span class='au'>Zemach, A., McDaniel, I. E., Silva, P. et al.</span>: <span class="ti">Genome-wide evolutionary analysis of eukaryotic DNA methylation.</span> <span class='so'>Science, 328, 916-919 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20395474" target="_blank">PubMed</a>]</span></li>
<li id="R8"><span class='au'>Takuno, S. & Gaut, B. S.</span>: <span class="ti">Body-methylated genes in <em>Arabidopsis thaliana</em> are functionally important and evolve slowly.</span> <span class='so'>Mol. Biol. Evol., 29, 219-227 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21813466" target="_blank">PubMed</a>]</span></li>
<li id="R9"><span class='au'>Zemach, A. & Zilberman, D.</span>: <span class="ti">Evolution of eukaryotic DNA methylation and the pursuit of safer sex.</span> <span class='so'>Curr. Biol., 20, R780-R785 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20833323" target="_blank">PubMed</a>]</span></li>
<li id="R10"><span class='au'>Jones, P. A.</span>: <span class="ti">Functions of DNA methylation: islands, start sites, gene bodies and beyond.</span> <span class='so'>Nat. Rev. Genet., 13, 484-492 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22641018" target="_blank">PubMed</a>]</span></li>
<li id="R11"><span class='au'>Kim, M. Y. & Zilberman, D.</span>: <span class="ti">DNA methylation as a system of plant genomic immunity.</span> <span class='so'>Trends Plant Sci., 19, 320-326 (2014)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/24618094" target="_blank">PubMed</a>]</span></li>
<li id="R12"><span class='au'>To, T. K., Saze, H. & Kakutani, T.</span>: <span class="ti">DNA methylation within transcribed regions.</span> <span class='so'>Plant Physiol., 168, 1219-1225 (2015)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26143255" target="_blank">PubMed</a>]</span></li>
<li id="R13"><span class='au'>Niederhuth, C. E., Bewick, A. J., Ji, L. et al.</span>: <span class="ti">Widespread natural variation of DNA methylation within angiosperms.</span> <span class='so'>Genome Biol., 17, 194 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/27671052" target="_blank">PubMed</a>]</span></li>
<li id="R14"><span class='au'>Seymour, D. K., Koenig, D., Hagmann, J. et al.</span>: <span class="ti">Evolution of DNA methylation patterns in the Brassicaceae is driven by differences in genome organization.</span> <span class='so'>PLoS Genet., 10, e1004785 (2014)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/25393550" target="_blank">PubMed</a>]</span></li>
<li id="R15"><span class='au'>Bewick, A. J., Ji, L., Niederhuth, C. E. et al.</span>: <span class="ti">On the origin and evolutionary consequences of gene body DNA methylation.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 113, 9111-9116 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/27457936" target="_blank">PubMed</a>]</span></li>
<li id="R16"><span class='au'>Schmitz, R. J., Schultz, M. D., Urich, M. A. et al.</span>: <span class="ti">Patterns of population epigenomic diversity.</span> <span class='so'>Nature, 495, 193-198 (2013)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/23467092" target="_blank">PubMed</a>]</span></li>
<li id="R17"><span class='au'>Dubin, M. J., Zhang, P., Meng, D. et al.</span>: <span class="ti">DNA methylation in <em>Arabidopsis</em> has a genetic basis and shows evidence of local adaptation.</span> <span class='so'>Elife, 4, e05255 (2015)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/25939354" target="_blank">PubMed</a>]</span></li>
<li id="R18"><span class='au'>Meng, D., Dubin, M., Zhang, P. et al.</span>: <span class="ti">Limited contribution of DNA methylation variation to expression regulation in <em>Arabidopsis thaliana</em>.</span> <span class='so'>PLoS Genet., 12, e1006141 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/27398721" target="_blank">PubMed</a>]</span></li>
<li id="R19"><span class='au'>Tenaillon, M. I., Hollister, J. D. & Gaut, B. S.</span>: <span class="ti">A triptych of the evolution of plant transposable elements.</span> <span class='so'>Trends Plant Sci., 15, 471-478 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20541961" target="_blank">PubMed</a>]</span></li>
</ol>

<h2>Ql}</h2>
<ol>
<span class='au'>ؑ</span>: <span class="ti">il.</span> <span class='so'>gX (1988)</span>
</ol>
<ol>
<span class='au'>cq</span>: <span class="ti">qîقڒ: RƓ̐if.</span> <span class='so'>uk (2009)</span>
</ol>
<ol>
<span class='au'>c ()</span>: <span class="ti">GsWFleBNX: ̕q@\獂@\܂.</span> <span class='so'>wl (2013)</span>
</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author"> iShohei Takunoj</span>
F2008N kww@_wȔmے CCN w@w擱Ȋw mC2010N čCaliforniawIrvineZ mC2012N čCaliforniawDavisZ moāC2013N葍w@w擱Ȋw D
e[}FiwƂDƂɁC`wx[XɂQmiwCWc`w̎@pC鐶ΏۂƂČi߂ĂDɁCGsWFleBNXi̗_Ɏ荞݁CVȐif̍\z߂ĂD
URLF<a href="https://sites.google.com/site/shoheitakunoj/home" target="_blank">https://sites.google.com/site/shoheitakunoj/home</a>
</div>
? 2016   Licensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
