RNA^pNƎRƉu

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iswECX h䌤j
emailF<a href="mailto:otake@virus.kyoto-u.ac.jp">| </a>
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̈Zr[, <strong>2</strong>, e013 (2013)@<a href="http://dx.doi.org/10.7875/leading.author.2.e013">DOI: 10.7875/leading.author.2.e013</a>
Osamu Takeuchi: <strong>Innate immunity and RNA binding proteins.</strong>

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<h2>v </h2>
@RƉúCâXgXɑ΂̕TolllêȂǂ̎êɂFC̉ǉN@\łDRƉuɂ}Nt@[WȂǂY鉊ǐTCgJĆCǂ̎NѐɏdvȖ͂ĂDTolllễVOiɂTCgJC`q͂߂ƂǂɊ֘A`q̔́C]ʂł͂ȂC]ʌmRNA̕і|ȂǂɂĂkɐ䂳CK؂ȉǉۂĂDmRNA̕і|̗}ɂ邱Ƃ̒m}CNRNAɂ킦CmRNA̕s艻𑣐iTristetraprolinRNAyfłRegnase-1ƂmRNA3f|̈ɌRNA^pNɂāCǂ̐ɂdv炩ɂȂĂDזEVOi`BnɂRegnase-1̔͒ڂɐ䂳邱ƂC]ʂłȂmRNÄ萫ɂĂCזE̊ÕVOiɂ蒼ڂɐ䂳ĂƍlDł́Cǂ̓]ʌ㐧̕q@\ɏœ_ĉD

<h2>͂߂</h2>
@Ɖun͑傫RƉuƊlƉuƂɕނ邱ƂłDlƉuTזEBזEƂ`q̍č\KvƂêɂ񎩌ȂF@\ƉuLɂďdvł̂ɑ΂CRƉu̓}Nt@[WזEȂǂɂSCQmɃR[hꂽêɂâFCɂâ̔r≊ǉɏdvȋ@\ł<a href="#R1"><sup>1)</sup></a>D܂CRƉu͎זElƉůɂĂdvȖ͂ĂDǂ̎Nѐɂ́CC^[CL1CC^[CL6CTNFitumor necrosis factorCᇉ󎀈qjȂǉǐTCgJCCI^C^[tF̂邱ƂmĂD̃TCgJC͕â̊ɂC}Nt@[WזEȂǂYD
@RƉu͏hɑ݂êa̍\iPAMPFpathogen-associated molecular patternCa֘Aqp^[jo邱ƂɂUD̂悤PAMPFp^[Féipattern recognition receptorFPRRjƂāCTollléiToll-like receptorFTLRjCRIG-IléiRIG-I-like receptorFRLRjCNODléiNOD-like receptorFNLRjCC^N`éiC-type lectin receptorFCLRjmĂ<a href="#R1"><sup>1)</sup></a>D̂CTolllêC^N`êI^^pNōזE̓Gh\[ɋǍ݂CC邢́Cݐ̎C|^pNCDNACRNAƂ܂܂PAMPFDɑ΂CRIG-Ilê͖ђʗ̈זEɋǍ݂2{RNA^pNłCזEɂRNAECX̊̔FɂďdvłDNODlêזEɑ݂êŁCyv`hOJtWFȂǈꕔTolllêƋʂPAMP̔FɂD
@Ct}\[ꕔNODlêCقƂǂ̃p^[Fê͍זEVOi`BnĈ`qDƂ΁CTolllêTLR3C̍זËăA_v^[^pNłMyD88ƌCɁCIRAKčזEɃVOi`BCTRAF6Ȃǂ̃|rL`VOi^pNւIBLi[[iIKKjDIBLi[[IKKCIKKCNEMO/IKK\CNF-BjQ^pNłIB_CrL`-veI\[nɂIB̕UĎʁCIBVNF-B͊jւƈڍsCǂɊ֘A`q̃v[^[̈ɌĂ̓]ʂDRIG-Ilê̓A_v^[^pNƂIPS-1čזEVOi`Bn邪C̉łIBLi[[NF-B̊jւ̈ڍs𑣐iȂǁCʂ̃GtFN^[^pNĂD܂CNODlê̈ꕔC^N`ễVOiNF-B邱ƂmĂCp^[FễVOi͂̑ɋʂ̃W[ƍlDTolllê̈ꕔRIG-IlễVOi͓]ʈqłIRF3IRF7iIRFFinterferon-regulatory factorjI^C^[tFYD
@̂悤ɁCRƉuɂăp^[Fê]ʂ̊ɂזEVOi`BnCGsWFleBbNȓ]ʂ̐@\ɊւẮC܂ŏڍׂȉ͂ȂĂDCTCgJC̎Y͓̐]ʂł͐C}CNRNA₳܂܂RNA^pNɂ]ʌ㐧̏dv炩ɂȂĂĂDł́C}CNRNAɊւ͂قɂ䂸<a href="#R2"><sup>2)</sup></a>CRNA^pNƈ`q̔Ƃ̊֘Aɏœ_ĂD

<h2>1DAUb`z񌋍^pNɂ鐧@\</h2>
@TCgJC⑝BqR[hmRNAɂ́C3f|̈AU𑽂܂AUb`ziT^Iɂ́CAUUUAjpxɑ݂邱ƂmĂD܂C̔z݂̑̕pxmRNA̕s萫Ƃւ邱Ƃ񍐂ĂDƂ΁CTNF̎hɑ΂ɗU`qmRNA3f|̈͑AUb`zƂ񍐂ĂCmRNA͂葬ƍlĂ<a href="#R3"><sup>3)</sup></a>D܂ŁCAUb`zɌ^pNƂẮCTristetraproliniTTPj₻̃t@~[^pNłZfp36L1CZfp36L2C܂CAUF1CKSRPCHuRȂǁCmĂ<a href="#R4"><sup>4)</sup></a>D
@TristetraprolinTolllêւ̎hɂ葁ɗU^pNłC2CCCH^WNtBK[̈D̗̈RNAhCƂĒmCmRNA3f|̈ɑ݂AUb`zƂ̌ɂďdvłDTristetraprolinTNFR[hmRNAAUb`zs艻i<a href="#F1">}1</a>jD܂łɁCTristetraprolin̓C^[tFC^[CL10͂߂܂܂ȃTCgJCmRNÄ萫̐ɂ邱Ƃ񍐂ĂDTristetraproliň}EXTNF̉ߏȎYɂ֐߉𔭏ǂ<a href="#R5"><sup>5)</sup></a>DTristetraprolinTNFR[hmRNA3f|̈ɌCEAfjyf܂CCR4-NOT̂N[g邱ƂɂCmRNA|AD|ȀꂽmRNA͂ÂăLbv\CXRN1GN\\[ȂǂRNAyfɂ蕪DAUF1TNFCC^[CL1CC^[CL6Ȃǂ̃TCgJCmRNA3f|̈AUb`zČCmRNAs艻邱ƂmĂ<a href="#R4"><sup>4)</sup></a>DAUF1}EX̓|ɂVbNɑ΂쐶^}EX󐫂łCTNFC^[CL1ƂǐTCgJCߏɎY邱Ƃ񍐂ĂDKSRPRNAXvCVO}CNRNA̎YȂǂɂ^pNł邪CAUb`zɌTCgJCR[hmRNAs艻قC̖|}邱Ƃ񍐂Ă<a href="#R6"><sup>6)</sup></a>Dɑ΂ClAUb`z񌋍^pNłHuŔCAUb`zmRNAזEɂĈ艻邱ƂmĂ<a href="#R7"><sup>7)</sup></a>DAUb`z񌋍^pN͎RƉułȂlƉu̐ɂ邱Ƃ񍐂ĂD̗ƂāCZfp36l1Zfp36l2͋BɂTזE̕ɕKvłC܂C}TזEa̔ǂ}ĂD܂CZfp36L2͐ԉ苅nOזE̎ȕɂ邱ƂmĂ<a href="#R8"><sup>8)</sup></a>D

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@AUb`z񌋍^pNɂmRNÄ萫̐</strong>
TCgJCȂǂR[hmRNA3f|̈ɑ݂AUb`zɂTristetraprolinCAUF1CHuRȂǂRNA^pNCmRNAs艻邢͈艻DTristetraprolinAUF1́CCCR4-NOT̂ɂ|ȀƂāCGN\\[ɂ3f5fւRNA̕CсCLbv\̏̂̂5f3fւRNA̕ЂNDCHuRAUb`zmRNA艻D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/11/Takeuchi-2.e013-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2013/11/Takeuchi-2.e013-Fig.1.png&amp;caption=fig1-caption-text]

@̂悤ɁCAUb`z񌋍^pN͉ǐTCgJC̎Y𐳂ɕɐ䂵Cǂ̃oXƂĂ邱Ƃ炩ɂȂĂD

<h2>2DRegnase-1̖Ɖuɂ</h2>
@mRNÄ萫AUb`ẑ݂Ő䂳Ă킯ł͂ȂD<em>Zc3h12a</em>`q̓}Nt@[WɂTolllễVOiɂ蔭UC̈`q̃R[h^pNRNasë您CCCH^WNtBK[̈D܂C̃^pN̓C^[CL6R[hmRNAƌCזEɋƂRNAyfɈˑĂmRNA𕪉D܂Ĉɏqׂ悤ɁC̃^pN͖Ɖun̐ɂĂdvłƂCM҂́CRegnase-1iregulatory RNase-1jƖi<a href="#F2">}2a</a>jDRegnase-1̓C^[CL6R[hmRNA3f|̈ɑ݂Xe[v̈ĂmRNAs艻<a href="#R9"><sup>9)</sup></a>i<a href="#F2">}2b</a>jD܂CRegnase-1}Nt@[WɂẮCTolllêւ̎hɉC^[CL6C^[CL12 p40Ȃǂ̎YiĂDRegnase-1mbNAEg}EX̓f̖@ɂĐ܂邪̒xC3TڂقǂŎS͂߁C12T܂łɂ͂قڑSႪSDRegnase-1mbNAEg}EX͌ɂĂ܂܂ȃNX̖ƉuOuĂC܂CRjR̂R2{DNAR̂ȂǎȍR̂YĂDRegnase-1̌̂Ƃł͌`זȆC܂CGtFN^[TזȆώ@ꂽDRegnase-1mbNAEg}EX̑gDώ@ƁCxȂǂ̑gDւ̃pCƂɁC`זE̐ZłCxɂĖƉuOuGYזEƉuOuAYזE̒ȑF߂ꂽD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@Regnase-1̍\Ƌ@\</strong>
iajRegnase-1̍\DDSGxxSFAsp-Ser-Gly-X-X-SerCPF_D
ibjRegnase-1̓C^[CL6R[hmRNAi<em>IL6</em> mRNAj3f|̈ɑ݂Xe[v\FC𒼐ڂɕ邱Ƃɂs艻ĂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/11/Takeuchi-2.e013-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2013/11/Takeuchi-2.e013-Fig.2.png&amp;caption=fig2-caption-text]

@Regnase-1̌ɂ艊ǂN镪q@\邽߁CCre-<em>loxP</em>npčזEɓٓIRegnase-1mbNAEg}EX쐻DTזEɓٓIRegnase-1ƂCSgɂRegnase-1mbNAEg}EXƓl̉ǐ𔭏ǂC8TĂ玩RɎS͂߂D܂C̃mbNAEg}EXɂ܂܂ȑւ̉ǍזE̐Z⒘BF߂CGtFN^[TזEь`זEĂD܂CTזEêւ̎hɂCD4zTזẼTCgJC̎YiĂCTזEɔRegnase-1TזE̊}͂Ă邱Ƃ炩ɂȂDCD4zTזEɂRegnase-1̕WImRNAɂČƂCTCgJCłC^[CL2CזE\ʃ^pNłICOSOX40C]ʈq̂Ȃłc-RelR[hmRNAĂ邱Ƃ炩ɂȂCRegnase-1͍זE킲ƂɓImRNAWIƂĖƉuזE̊𐧌䂵Ăƍlꂽ<a href="#R10"><sup>10)</sup></a>D
@ȏ̌ʂCRegnase-1͖Ɖůɂ^pNR[hmRNARNAyfƂĒڂɕ邱ƁC܂CRƉuъlƉuɂ͂炭זEɂāCȖƉủǐ̔ǂ}邽ߏdvȃ^pNł邱Ƃ炩ɂȂDŋ߂ɂȂCRegnase-1ƋtɁCC^[CL6R[hmRNA3f|̈Ĉ艻^pNArid5ȃ݂񍐂Ă<a href="#R11"><sup>11)</sup></a>D

<h2>3DRoquinɂTזEюRƉu̐</h2>
@RoquińCG`jg\Af̓^ɂψقɂ莩ȖƉu𔭏ǂ悤ɂȂ}EXnɂāČ`qɃR[h^pNƂČoꂽ<a href="#R12"><sup>12)</sup></a>D̕ψك}EX́CȍR̂̎YCBɂ󒆐ShEwp[TזȆCTזEɂICOS̔̑悵DRoquin<em>Rc3h1</em>`qɃR[hCrL`K[[ƍlRINGtBK[̈ɂ킦CRNAƌCCCH^WNtBK[̈CсCROQhCDRoquinICOSȂǂR[hmRNAɒڂ̓}CNRNAԐړIɌC̕s艻UƍlĂDRoquińCWIRNAɒEAfjyf܂CCR4-NOT̂N[g邱ƂɂC̕𑣐ii<a href="#F3">}3</a>jD܂CRoquinTNFR[hmRNA3f|̈ɑ݂Xe[v\ɌƂ̕񍐂CRoquinɕψق}EXł̓|̓^ɑ΂TNF̎YiĂ<a href="#R13"><sup>13)</sup></a>DāCRegnase-1ƓlɁCRoquin͊lƉuюRƉuƂɐ䂷RNA^pNłƍlD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@RoquinɂmRNÄ萫̐</strong>
RoquinICOSTNFR[hmRNA3f|̈ɑ݂Xe[v\FCCR4-NOT̂N[gC|ȀmRNA̕ЂND
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/11/Takeuchi-2.e013-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2013/11/Takeuchi-2.e013-Fig.3.png&amp;caption=fig3-caption-text]


<h2>4DƉuזEɂVOi`BɂmRNÄ萫̐</h2>
@ɏqׂ悤ɁC]ʂ͍זE̊O̎hɂזEVOi`Bnkɐ䂳Ă邱Ƃ悭mĂD킦āC̌ɂCmRNÄ萫ꎩ̂זE̊O̎hɂ萧Ă邱Ƃ炩ɂȂD
@Ƃ΁CRƉuɂ芈MAPLi[[t@~[̂ЂƂłp38 MAPLi[[́CAUb`zRNA艻邱ƂmĂD̕q@\̂ЂƂƂāCp38 MAPLi[[MK2CMK2Tristetraprolin_邱ƂD_ꂽTristetraprolin14-3-3Ƃ΂^pNƌ邱ƂɂCTNFȂǂR[hmRNAs艻銈ቺƍlĂi<a href="#F4">}4a</a>jD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@ƉuזEɂVOi`BɂmRNÄ萫̐</strong>
iajRƉuhɂmRNÄ萫̐DTolllêւ̎hɂ芈p38 MAPLi[[MK2_CMK2Tristetraprolin_D_ꂽTristetraprolin14-3-3ƌCWImRNA痣ED܂CTolllêւ̎hIBLi[[CIBLi[[Regnase-1_ărL`-veA\[nɂ镪𑣐iD̕q@\ɂCTNFC^[CL6R[hmRNA͈艻D
ibjTזEêւ̎hMALT1CMALT1Regnase-1𒼐ڂɐؒfDɂWImRNÄ萫܂邱ƂCTזE̊Ɋ^D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/11/Takeuchi-2.e013-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2013/11/Takeuchi-2.e013-Fig.4.png&amp;caption=fig4-caption-text]

@Regnase-1^pN̏CĖƉůɂ_Ci~bNȐĂDRegnase-1͒ԂɂĂƉuזEɔĂĆC}Nt@[WɂăC^[CL6R[hmRNA̔Sɗ}邽߂ɏdvłD̂Ƃ́CRegnase-1זEɂĂ͒Ԃł쐶^̍זEƔrăC^[CL6mRNAĂ邱Ƃ炩łDTolllêւ̎h邢̓C^[CL1ɂMyD88hɑ΂āCRegnase-1IBLi[[̂ɂ蒼ڂɃ_CrL`-veI\[nɂ葁ɕ邱Ƃ炩ɂȂ<a href="#R14"><sup>14)</sup></a>DRegnase-1ɂIBLi[[ɂ胊_Asp-Ser-Gly-X-X-SerƂA~m_z񂪕ۑĂi<a href="#F2">}2a</a>jCIBLi[[זEłTolllêւ̎hɑ΂Regnase-1݂͂̕ȂȂقC_2̃Zcɕψق𓱓ꍇɂRegnase-1͋̕NȂȂC܂CC^[CL6R[hmRNA̎Y苭}D̂悤ɁCTollle-IBLi[[oH́CNF-B]ʂ̊iANZĵ݂Ȃ炸CRegnase-1𕪉邱Ƃœ]ʂɑ΂u[L邱ƂɂCC^[CL6Ȃǂ̉ǐTCgJC̐vȎYĂƍli<a href="#F4">}4a</a>jD܂CRegnase-1̓}Nt@[Wɂĕꂽ̂CԂōĔĂD̍ĔɂRegnase-1̓]ʂ̊Ă邪Cɂ킦CRegnase-1R[hmRNÄ萫Ă邱Ƃ炩ɂȂDRegnase-1́CRegnase-1ꎩ̂R[hmRNAWIƂDRegnase-1^pNƁCɂRegnase-1R[hmRNA艻ĈƂԍRegnase-1̍ĔɊ^Ă̂ƍlꂽD
@܂CRegnase-1TזEɂĂIȐĂ邱Ƃ炩ɂȂĂDTזEê̊̃VOiɂĂRegnase-1̕F߂邪C̋@\̓veI\[̑jQ܂ɂ}ꂸC}Nt@[WɂTolllêւ̎hɑ΂镪̋@\Ƃ͈قȂ̂ƍlꂽDTזEɂRegnase-1́̕CBCL10MALT1/paracaspaseTזEł͔F߂ȂƂCBCL10MALT1/paracaspaseƂ̂̕dvłƎvꂽDMALT1̓JXp[[̂悤ɃAMjĉŐؒf^pNyfCTזEɂNF-B̊ɏdvȃ^pNłDȂCMALT1̃^pNyfNF-B̊ɂ͕K{ł͂ȂƍlĂC̊ɊւẮCErL`yfłA20̂قɂ͂킩ĂȂDM҂́CTזEMALT1̃^pNyfɑ΂jQ܂łzVRPR-fmkɂ菈ƁCTזEêւ̎hɑ΂Regnase-1̕NȂȂ邱ƂoD܂CMALT1Regnase-1111Ԗڂ̃AMjĉŐؒf銈ƂoDRegnase-1111Ԗڂ̃AMjcAjcɒuψّ̂TזEêւ̎hɑ΂ĂȂƂCMALT1ɂRegnase-1̐ؒf̕у^pN̕s萫ɂďdvł邱Ƃ炩ɂȂD܂CTזEêւ̎hɑ΂c-RelCICOSCOX40R[hmRNAƂRegnase-1̕WImRNA͈艻邪CTזEzVRPR-fmkɂ菈邱Ƃɂ肱mRNA͕s艻ƂCMALT1ɂRegnase-1̕TזEɂGtFN^[^pN̔ɉe邱Ƃꂽ<a href="#R10"><sup>10)</sup></a>i<a href="#F4">}4b</a>jD
@̂悤ɁCƉuזEזE̊ÕVOíC܂ł̃ZghO}Ƃē]ʂ݂̂ł͂ȂCmRNÄ萫ڂɐ䂷邱ƂɂCƉun̐ɏdvȖ͂Ă邱Ƃ炩ɂȂĂD

<h2>5DTCgJC̎Y̖|ɂ鐧</h2>
@TCgJC͖̔|ɂĂĂDƂ΁CGAIT̂́C{\[̍\^pNłL13aCO^~-vtRNAyfCNS1֘A^pN1COZAfqh-3-_fqhQi[[\DC^[tFR[hmRNA3f|̈ɑ݂GAITzɌC̖|}邱ƂmĂ<a href="#R15"><sup>15)</sup></a>D
@܂CI^C^[tF̎Y|ɂĐ䂳Ă邱ƂmĂD|}qł4E-BP14E-BP2͓]ʈqłIRF7R[hmRNA̖|}ĂC̖|}qזEł̓ECX̊ɑ΂I^C^[tF̎YiĂC܂CECX̊ɑ΂銴󐫂ቺĂ<a href="#R16"><sup>16)</sup></a>D܂CC^[tFɂ蔭̗UOASL1IRF7R[hmRNA5f|̈ɌC̖|𕉂ɐ䂷邱Ƃ񍐂Ă<a href="#R17"><sup>17)</sup></a>Dɑ΂C|JnqłeIF4ÉC209Ԗڂ̃Zc_邱ƂɂIB̖|JnDeIF4Ẽ_ψّ̂𔭌}EXłIB̖|󂪒ቺ邱ƂɂNF-B芈CC^[tF̎Y̘iN<a href="#R18"><sup>18)</sup></a>D̂悤ɁCmRNÄ艻ł͂ȂC|܂RƉuɂIɐ䂳ĂD

<h2></h2>
@ł́CRƉu̓]ʌ̐@\RNA^pN̊ϓ_DRegnase-1}EX̗Ⴉ݂ĂC]ʌ㐧͐̂ɂP퐫̈ێɏdvł邱Ƃ͖炩łDɁC܂ŁCǉ̐ɂזEVOi`Bn͓]ʈq̊ɂ̂SłƍlĂCmRNÄ萫|̐CזEVOi`Bn̉ɂĒڂɐĂ邱ƂCł͂邪炩ɂȂĂDȂC͂̕܂WrłƂ킴ȂD܂ŁCqgłRNÄ^pN400ȏ񍐂Ă邪C̑͋@\\ɂ͖炩ɂȂĂȂ<a href="#R19"><sup>19)</sup></a>D܂C^pNR[hȂRNAƂẮC}CNRNÂقɂlincRNAilarge intervening non-coding RNAjȂǂ݂CقȍזEǍ݂Ƃ݂̂邱Ƃ璍ڂ߂ĂDlincRNAɂTolllê̂TLR4ւ̎hɑ΂̗Û݂<a href="#R20"><sup>20)</sup></a>CȂłClincRNA-Cox2͖ƉuɊ֘A`q̔]ʂ̒iKɂĐ䂵Ă邱Ƃ񍐂Ă<a href="#R21"><sup>21)</sup></a>ĎɂCRNA^pNmRNȂS̑炩ɂȂC܂ł̓]ʂ𒆐SƂ]ʌ㐧܂߂IȂ̗ւƁCǂ̕q@\̍l]ĂƂ҂D܂CRegnase-1RNAyfłȂCɃ_Ci~bNȔ̕ωNƂC̊┭𐧌䂷邱Ƃɂ艊ǐ̎Ö@ɂȂ邱Ƃ҂D

<h2> </h2>
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</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">|  iOsamu Takeuchij</span>
F2001N ww@wnȔmے CC2002N čDana-Farber Cancer InstituteC2004N wa C2007N  yoāC2012N苞swECX D
e[}FRƉuɂ鉊ǂ̐@\CƂɓ]ʌ㐧̊ϓ_疾炩ɂD
URLF<a href="http://www.virus.kyoto-u.ac.jp/Lab/Takeuchi_HP/index.html" target="_blank">http://www.virus.kyoto-u.ac.jp/Lab/Takeuchi_HP/index.html</a>
</div>
? 2013 |   Licensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
