ǏזEƒ׋ۂƂ̑ݍp

<strong> E|c </strong>
iww@wn Ɖuwj
emailF<a href="mailto:okumura@ongene.med.osaka-u.ac.jp"> </a>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
̈Zr[, <strong>5</strong>, e007 (2016)@<a href="http://dx.doi.org/10.7875/leading.author.5.e007">DOI: 10.7875/leading.author.5.e007</a>
Ryu Okumura & Kiyoshi Takeda: <strong>Crosstalk between intestinal epithelial cells and commensal bacteria.</strong>

<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/08/Takeda-5.e007-PDF.pdf" target="_blank"><img class="size-full wp-image-112 alignright" title="Download PDF" src="/images/downloadPDF.png" alt="Download PDF" width="100" height="20" /></a>
<p>
<p>
<p>
<p>
<p>
<!--more-->

<h2>v </h2>
@ǏזE͉h{␅̋zƂ@\ƂƂɁC̒׋ۂ環ǂ̑gD܂C׋ۂɑ΂ߏȖƉu邽߂̔SoA\zD܂C׋ۂƔSŗLwɑ݂ƉuSזEƂ̂ɑ݂Ca׋ۂ܂ޒ׋ۂ̎h邢͂ɗRRƉuSזEɓ`B邱Ƃɂ蒰ǖƉun𐧌䂵CǂɂP퐫̈ێɑ傫vD䂦CǏזE̋@\`Iȑfɂ莸C邢́Cvɂ蒰t[ɗꂪƁChƒt[Ƃ̃oXČʁCǂɉǂЂND

<h2>͂߂</h2>
@qg܂ސҒœ͐Hێ悵z邱Ƃɂ萶ێD܂łȂCǂ͂̋zSB̊튯łCێ悷H܂ފÖٕ͏ǂʉ߂D܂CƂƂɂ܂܂ȍ׋ۂǂɐNCh{LxȊ̂ƒǂɒ蒅đBCt[Ƃ׋ۑp`D׋ۂ͂ɋ݂̂Ȃ炸CHɗRh{f𔭍yhɂȂӎY񋟂邱ƂɂhƃEB-EB̊֌WzD{͊OGƂȂ肤钰׋ۂƂ̗ǍDȊ֌ẄێɕsȂ̂ǂɓL̖Ɖu@\łC׋ۂƔSŗLwɑ݂ƉuSזEƂ̂ɑ݂钰ǏזE͔SoA\z邱Ƃɂ蒰׋ۂƒǏgDƂ𕪂ւāCɁCƉuSזEɃVOi`B邱Ƃɂ蒰ǖƉun𐧌䂷D̃r[ɂẮCǏזE̒ǖƉunɂ@\𒰓׋ۂƂ̑ݍp𒆐SɉD
@ȂC׋ۂƒǖƉuɂẮC<a href="http://leading.lifesciencedb.jp/2-e011/" target="_blank">{c , ̈Zr[, <strong>2</strong>, e011 (2013)</a> QƂꂽD

<h2>1D܂܂ȒǏזEƂ̋@\</h2>
@̒׋ۂ܂ފÖٕ݂̑钰ǂɂāCǖƉun͒ǏזEƉuSזEȂǂ܂܂ȃ^Cv̍זEɂ萧䂳i<a href="#F1">}1</a>jD̔SׂĂ̒ǏזE͉A|ɑ݂钰Ǐ犲זETAזEitransit-amplifyingזEjւĕCƂƂOт̂قֈړC̊Jn3`4Oт̒ɂăA|g[VXNǍoւƒEDn@\IȒǏזÉCzזECtזECPanethזECזEC^tgזECMזEɕi<a href="#F1">}1</a>jD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@ɂ钰ǏזEƖƉuSזE</strong>
ǖƉu͂܂܂ȒǏזEƉuSזEɂ萧䂳D@\IȒǏזÉCzזECtזECPanethזECזEC^tgזECMזEɕނD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/08/Takeda-5.e007-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2016/08/Takeda-5.e007-Fig.1.png&amp;caption=fig1-caption-text]

@zזE͉h{␅̋zɓזEłCǏזȆ啔߂D[ʂ̍זEɂ͍qƂ΂OтȂ\Ch{f͔Oт̍זEɑ݂yfɂzזEɋzD܂CzזE̒[ʂ̕\ʂ͓߂Ƃ΂铜̏Ŵɂ肨ĂC׋ۂ̒ǏזEւ̐NQ<a href="#R1"><sup>1)</sup></a>DtזE͔St̎听ł郀`Ƃ^pN𑽗ʂɎY傷邱Ƃɂ蒰̔SSt̍P퐫ێCǏזEւ̒׋ۂ̐NӂD̉A|ɑ݂PanethזE͍Rۃyv`h̎YѕɓזEłCfBtFVt@~[^pNRegIIIt@~[^pNȂǂ̍Rۃyv`hY׋ۂ̐Nɑ΂hɕsłƂƂ<a href="#R2"><sup>2)</sup></a>Cߐڂ钰Ǐ犲זENotchVOi`B邱Ƃɂ蒰Ǐ犲זE̊זEƂĂ̋@\ێjb`ƂĂdvȖ͂<a href="#R3"><sup>3)</sup></a>DזE͏זE1x߂}Ci[ȍזEł邪CHa̎ⓜmRVXgLjCKXgCZgjȂǂ̏ǃz𕪔傷邱Ƃɂ݉tXt̕储従^𑣐i̐ɏdvȖ͂D̈CߔNCRVXgLj̓}Nt@[WɂU^_fyf̎Y}ƂCǃzƒǖƉunƂ̑ݍp炩ɂꂽ<a href="#R4"><sup>4)</sup></a>DזEƓn̍זÊЂƂŁCŋ߁Cڂ߂Ă̂^tgזEłC[ʂɔׂȖт̖W悤ȍ\i^tgC[jƂ炩疼ÂꂽD܂ŁC̖͂قƂǖ炩ɂĂȂC2016NC3̌O[vɂC^tgזE͏徒ƃC^[CL25YC2^Rp邱Ƃɂ徒̔rɑ傫^邱Ƃ炩ɂꂽ<a href="#R5"><sup>5-7)</sup></a>DMזE͍R̎荞݂ɓזEŁCpCGȂǃphEǏgDɎU݂DGp-2Ƃ׋ۂ̎êȂǂĊǍoR荞<a href="#R8"><sup>8)</sup></a>CphE̎זEɍR邱ƂɂƉuOuA̎Yɑ傫^D
@̑푽lȒǏזE׋ۂSŗLwɑ݂ƉuSזEƑݍp邱ƂɂCǖƉun͍Iɐ䂳ĂD

<h2>2DǏזEɂ`SoA</h2>
@100Ƃ邨т̒׋ۂ݂钰ǂɂ́C׋ۂ環ǂ̑gDی삷C邢́C׋ۂɑ΂ߏȖƉu邽߁CǏזEɂ`SoA݂DSoA͕IȃoAƉwIȃoA2ɑʂDIȃoAɂ́C̔S핢StwCǏזE̕\ʂɑ݂铜^pN̓ɂ`铜߁CזEڒuł閧ѐڒCIȏǂƂĒǏgDւ̒׋ۂ̐NӂDwIȃoAɂ̓fBtFVt@~[^pNCRegIIIt@~[^pNCNgtFC]`[ȂPanethזE𒆐SɒǏזEYRۃyv`h܂܂D`IȑfȂǂɂ肻̔SoA̋@\j]ƒt[̕ω⒰ǏgDւ̒׋ۂ̐Nɂ蒰ǂ̉ǂNChƒ׋ۂƂ̗ǍDȊ֌W͑傫D
@Ƒ咰͓ǂł͂邪C̑gD̍\⒰ǏזE̍\͈قȂƂƂɁCSoA̋@\傫قȂi<a href="#F2">}2</a>jDł͔StYtזE̐咰Ɣ׏ȂCǏזEStwD̈ŁC̉A|ɂ͑咰ɂ݂͑ȂRۃyv`h̎YɓPanethזE݂C׋ۂƒǏgDƂ𕪂ւĂ̂ɏdvȖ͂DPanethזE܂ޒǏזE番傳Rۃyv`h͍CACҒœɂ܂ōLۑĂCA~m_c𑽂܂ނƂɂ萳ɉדdCɑѓd׋ۂ̍זEƌ̂Cä̗悪זE̓ߐ𘴐i邱Ƃɂ芈𔭊DǏזEp^[Féipattern-recognition receptorFPRRjłTolllêNodlê׋ۂɂhƍRۃyv`h̎YiCa׋ۂɊƂɂ͔SŗLwɑ݂Th17זE3^RpɂYC^[CL17C^[CL22Ȃǂ̃TCgJCɂ蒰ǏזEɂRۃyv`h̎Y͂ɘi<a href="#R9"><sup>9)</sup></a>DǏזEɂYRۃyv`hƂāCȑOCfBtFVt@~[^pNJeVW\ÎƂĒmĂCߔNCVC^N`łRegIIIt@~[^pN肳ꂽDRegIIIt@~[^pN̂ЂƂłRegIIIƂPanethזEɂTollle-MyD88VOi`BnĎYCOzۂɑ΂Rۊ𔭊<a href="#R10"><sup>10)</sup></a>DɁCǏזEɓٓIMyD88mbNAEg}EXRegIIImbNAEg}EX̏ɂĂ͒׋ۂƒǏזEƂߐڂĂƂCRegIII͏ɂĒ׋ۂƒǏgDƂ𕪂ւĂ̂ɏdvȖ͂Ƃ炩ɂꂽ<a href="#R11"><sup>11)</sup></a>D

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@ё咰ɂSoA</strong>
iajDɍRۃyv`h܂މwIȃoA׋ۂ𐧌䂷D
ibj咰DStw𒆐SƂIȃoAɂ蒰׋ۂƒǏgDƂւĂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/08/Takeda-5.e007-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2016/08/Takeda-5.e007-Fig.2.png&amp;caption=fig2-caption-text]

@̖100{Ƃ邨т̒׋ۂ݂咰ɂPanethזE݂͑ȂCtזE̐StwǏזEĂC̔Stw͊OStwƓStw2̑wɕ<a href="#R12"><sup>12)</sup></a>DSt̎听͔tזEY铜^pÑ`łC`͕^`Ɩ^`2ɕDё咰ɂĂ͕^`łMuc2St̎听łCʂɕt<em>O</em>-^St̔S𐶂C܂CǏזE̕\ʂ̓ƌڒ悤Ƃ钰׋ۂɑ΂IɌ邱Ƃɂ蒰׋ۂ̐N邢͐ڒӂD咰̒ǏזE̒ɂStwɂĂMuc2Ɍ\ƂCOStw͂Muc2̖ȍ\h傠邢͒׋ۂ̃veA[[ɂ蕪񂾏ԂɂD܂CقƂǂ̒׋ۂ͊OStwɐCStw͂قږۏԂɕۂC咰ɂĂ͓Stwɂ蒰׋ۂƒǏgDƂ͕ւĂĂ<a href="#R12"><sup>12)</sup></a>D䂦CStw\Muc2}EXMuc2<em>O</em>-^̕tɕsȍyfłC1galt1}EX͓StwC׋ۂ̒ǏgDւ̐NF߂D
@Rۃyv`h̎YɓPanethזE݂Ȃ̂ɂ炸Cт̒׋ۂ݂咰ɂēStwۂɕۂC׋ۂƒǏgDƂւĂ@\͂܂Ŗ炩ɂĂȂDM҂́C̓Stwۂɕۂ邱Ƃɑ咰̋zזEɓٓIɍLypd8ƂGPIAJ[^^pNdvȖ͂Ƃ𖾂炩ɂ<a href="#R13"><sup>13)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/12339" target="_blank">V_r[</a> łfځjDLypd8<em>N</em>-^ɂ荂xɏCĂCǏזE̒[̕\ʂɔCǏזE̕\ʂPIɗV咰̊Ǎoɕ傳DVLypd8͑咰ۂ<em>Proteus</em>׋ۂȂǕږт׋ۂ̕ږтƗDIɌC̉^}邱Ƃɂ蒰ǏgDւ̐NӂłD܂CLypd8mbNAEg}EXɂĂ͓StwђǏgDւ̒׋ۂ̐Nώ@C^̍咰ۂ<em>Proteus</em>׋ۂLӂɑoꂽDLypd8mbNAEg}EX̓fLXg_igEɂIȒɑ΂銴󐫂iĂĈƂCLypd8咰ɂĒ׋ۂƒǏgD𕪂ւĂ邱Ƃɂ蒰ǂ̉ǂӂƂ炩ɂꂽi<a href="#F3">}3</a>jD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@Lypd8̋@\Lypd8mbNAEg}EX̕\^</strong>
iaj쐶^}EXDLypd8͑咰̒ǏזEɍCǏזEPIɗVǍoւƕ傳DLypd8͑咰ۂ<em>Proteus</em>׋ۂȂǕږт׋ۂƗDIɌ̉^}邱ƂɂNӂD
ibjLypd8mbNAEg}EXDږт׋ۂǏgDɐNCɂƂȂIȒɑ΂銴󐫂iD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/08/Takeda-5.e007-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2016/08/Takeda-5.e007-Fig.3.png&amp;caption=fig3-caption-text]

@ȏ̂悤ɁC܂܂ȒǏזEɂ\zSoAɂCǂ̑gD͕a׋ۂ܂ޒ׋ۂ܂Cɂ蒰ǂɂP퐫͈ێĂD

<h2>3D׋ۂǏזEɂڂe</h2>
@ǂɂ100BacteroidesFirmicutes𒆐SƂ푽lȍ׋ۂC̒׋ۂ͒Zb_r^~ȂǂY邱Ƃɂhɉh{ʂŉbƂƂɁC_o`BłZgj̕𑣐iȂǁCߔŃC_onւ̉eڂĂ<a href="#R14"><sup>14)</sup></a>D܂CǖƉun͒׋ۂ邢͂̑ӎYCH̉h{fƂvɂ萧䂳DہC׋ۂ݂̑Ȃۃ}EXɂĂ̓pCGCǗphECԖp߂ȂǒǂɊ֘A郊pgD͒`łCSŗLwɑ݂ƉuOuAYזETh17זE̐ȂCa׋ۂ̊IȒfɑ΂銴󐫂̘iF߂<a href="#R15"><sup>15,16)</sup></a>D
@ǂɂP퐫̈ێɈSǏזE܂׋ۂ炳܂܂ȉeĂ邱ƂCۃ}EXɂ̒׋ۂ蒅mgoCI[gZppȂǂɂ薾炩ɂꂽD׋ۂ̂ЂƂłZOg׋ۂ𖳋ۃ}EXɒ蒅邱ƂɂCZOg׋ۂ̒ǏזEɐڒ邱Ƃɂ蒰ǏזĚA~ChAȂǂ̎YiČA~ChA͔SŗLwɂTh17זE̕U<a href="#R17"><sup>17,18)</sup></a>DM҂̌O[v́C׋ۂɗRATPSŗLwɂTh17זE̕U邱Ƃ𖾂炩ɂ<a href="#R19"><sup>19)</sup></a>C܂CATPyf̂ЂƂłEntpd7}EXɂĂ͏̊ǍoɂATP̔Zx㏸SŗLwɂTh17זE邱Ƃ񍐂<a href="#R20"><sup>20)</sup></a>D̒׋ۂ邢͂ɗRATPɂ蕪̗UꂽTh17זÉCC^[CL17C^[CL22ƂǐTCgJCY邱Ƃɂ蒰ǏזE̍Rۃyv`h̎Y𑣐iC̍Rۃyv`h׋ۂ𐧌䂷ƂAD
@ߔNCǏזEɂă^pÑtRVSFut2}EXɂĂ͒ǏזEɔ閌^pNtRVꂸC<em>Salmonella thyphimurium</em><em>Citrobacter rodentium</em>Ƃa׋ۂ̊ɑ΂銴󐫂iĂƂCǏזEɂ閌^pÑtRVhɏdvł邱ƂC̃tRVSŗLwɑ݂3^RpZOg׋ۂȂǂ̒׋ۂɈˑĕ傳C^[CL22ɂU邱Ƃ炩ɂꂽD̂悤ɁC^pNƂƂɒǏזEɔ铜͔SoA̋@\ɂďdvłC܂C̓̍\׋ۂɂωD
@׋ۂTollle-MyD88VOi`BnNodlê̂ЂƂłNLRP6ĔtזEɂSt̎Y𑣐iDƂɁCtזE̔St̕ɂNLRP6-Ct}\[oHdvłCCt}\[̊ɂI[gt@W[̊tזE̔St̕傪UCCt}\[Ɋ֘A^pN}EXɂĂ͔tזE̔St̕oQCStwt[̗idysbiosisjNƂƂɁCǂ̉ǂɑ΂銴󐫂傷<a href="#R21"><sup>21)</sup></a>D܂Cɏqׂ悤ɁCPanethזE͒׋ۂTollle-MyD88VOiɈˑRegIIIȂǂ̍Rۃyv`hYDɁCǏזETolllêĒ׋ۂɂhBAFFAPRIL̎YUCBAFF邢APRILɂBזECD40ɔˑIȃNXXCb`U邱ƂɂCa׋ۂ̒蒅т̓őfɑ΂hIɂ͂炭ƉuOuA̎YɊ^<a href="#R22"><sup>22)</sup></a>D
@׋ۂ̑ӎY܂ǏזEɒړI܂͊ԐړIɉeD׋ۂYH@ۂى邱ƂɂY闏_CvsI_C_Ȃǂ̒Zb_́Ĉ̃GlM[Ƃėp݂̂Ȃ炸CǏזȆB𑣐itזE̔St̎Y𘴐iƂSoÄێɂdvłDM҂̌O[v́C׋ۂɂYgvgt@̑ӎYłCh[ǏזEɂClaudin-7OcculudinȂǖ邢͐ڒɊ֘A^pN̔𘴐iSoA𑝋邱Ƃ𖾂炩ɂ<a href="#R23"><sup>23)</sup></a>Dʂ̌O[v́CCh[ǏזEPXRƂêh邱ƂɂTolllẽVOiɈˑčזEڒq̔𘴐i邱Ƃ񍐂<a href="#R24"><sup>24)</sup></a>D
@ȏ̂悤ɁC׋ۂ₻̑ӎYɂ蒰ǏזE̔SoAɊ֘A^pN̔@\͐䂳CǏזE܂܂܂ȋ@\ɂ蒰׋ۂ𐧌䂵C׋ۂƒǏזE͂ꂼꑊ݂ɍpƂɂ蒰ǂɂP퐫͈ێi<a href="#F4">}4</a>jDCǂ̓ẽ^Qm͂⃁^{[͂iނƂɂCɒ׋ۂ₻̑ӌoHCɂ͖m̑ӎY炩ɂCSoA̋@\𐧌䂷VȈq肳邱Ƃ҂D

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@ɂvƒǏזEƂ̑ݍp</strong>
׋ۂ₻ɂӎY܂ފv́CǏזEƉuSזEɍp邱ƂɂSoA܂ޒǖƉunɎX̉eڂD܂Ca׋ۂ܂ޒ׋ۂ͊vɂ萬nSoAɂ萧䂳CǂɂP퐫͈ێD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/08/Takeda-5.e007-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2016/08/Takeda-5.e007-Fig.4.png&amp;caption=fig4-caption-text]


<h2>4DSoA̔j]⒰t[̗ɂЂN钰ǂ̉</h2>
@ᇐ咰N[aɑ\鉊ǐ́C܂܂Ȉ`Iȑf邢͊v܂Ĕǂ鑽q̎łD`IȑfɊւẮCߔÑQmCh֘A͂ɂC<em>FUT2</em>`qC<em>MUC1</em>`qC<em>MUC19</em>`qC<em>NOD2</em>`qƂSoA̋@\Ɋ֗^`qɊ֘A`qƂĂĂDɁCǐ̊҂̒ǂɂĂ͎ۂɃfBtFVȂǂ̍Rۃyv`h̎YSt̎Y̒ቺƂSoA̋@\̒ቺF߂Ct[̑l̒ቺCFirmicutesɑ׋ۂ̌C咰ۂȂǂ̒׋ۉȂ܂Proteobacteriaɑ׋ۂ̑Ƃt[̗ꂪmFĂDƂC`IȑfɂSoA̋@\̒ቺ邢͊vɂ钰t[ُ̈ɂCh̔SoAƒt[Ƃ̃oX邱Ƃɂ蒰׋ۂ̒ǏgDւ̐NeՂɂȂƁCɑ΂h̖Ɖuɂ艊ǂNƍlDۂɁCSoA̋@\Ɋ֘A`q}EXɂĒRǂ邱ƁC邢́CIȒfɑ΂銴󐫂i邱Ƃ񍐂ĂD
@ё咰ɂSt̎听łMuc2}EXC邢́C<em>O</em>-^̏CQC1galt1}EXɂẮC咰ɂēStw`ꂸǏgDւ̒׋ۂ̐N₻ɂƂȂ̎RǂF߂<a href="#R25"><sup>25,26)</sup></a>DǏזEɔNodlê̂ЂƂłNLRP6}EXɂĂ͔tזE̔St̕傪܂N炸Cɂ咰̓Stw`ƂȂ蒰t[̕ωɂIȒѕa׋ۂ̊ɑ΂銴󐫂i<a href="#R27"><sup>27)</sup></a>DɁCt[̗݂̂`qσ}EXƖ쐶^}EXƂ𓯂P[WŎ炷ƁCt[̗ꂪ쐶^}EXɓ`dǂ̉ǂ̊󐫂iD܂CMyD88mbNAEg}EXɂĂ͒ǏזE̍Rۃyv`h̎Y̒ቺƂSoA̋@\̒ቺNCIȒɑ΂銴󐫂i<a href="#R28"><sup>28)</sup></a>DN[aɑ΂銴󐫈`qł<em>NOD2</em>`q}EXłPanethזEɂNF-B̊N炸fBtFVȂǂ̍Rۃyv`h̎Yቺ<a href="#R29"><sup>29)</sup></a>DNOD2mbNAEg}EX͒RǂȂC<em>Helicobacter hepaticus</em>fɂĖ쐶^}EXƔrĉ񒰂̖[ɃN[al̓ǂF߂<a href="#R30"><sup>30)</sup></a>D܂CǏזEɔ^pN̗AɂAP-1B}EXɂĒǏזEɂfBtFVȂǂ̍Rۃyv`h̎YቺC܂C^ƉuOuA̒ǂւ̗AQC̔SoA̋@\̒ቺɂN[al̖Ǒ݂<a href="#R31"><sup>31)</sup></a>D
@M҂́Cɏqׂ悤ɁCǏזEɔLypd8Ƃɕږт׋ۂ̒ǏזEւ̐N}邱Ƃ񍐂CLypd8mbNAEg}EXɂĂ͓Stwւ̒׋ۂ̐NF߂CIȒɑ΂銴󐫂i邱Ƃ𖾂炩ɂ<a href="#R13"><sup>13)</sup></a>DɁC̊󐫂͕ږт׋ۂɑ΂󐫂̂R܂łQ^}CVO^ꍇɂ͒ቺC΂ɁCږт׋ۂɑ΂󐫂̂ȂoR}CVO^ł͍׋ۂ̌̌ɂږтOAۂCɂƂȂIȒɑ΂銴󐫂ɘi邱Ƃ炩ɂꂽD
@ȏ̂悤Ȉ`qσ}EXpɂCǏזEɂ`SoA̋@\̒ቺ₻ɂƂȂt[̗ɂ蒰ǂ̉ǂɑ΂銴󐫂i邱ƂCǏזEƒ׋ۂƂ̑ݍpɂ蒰ǂɂP퐫ێ邱Ƃ炩ɂꂽD

<h2></h2>
@܂܂ȒǏזEƂ̋@\C܂CǏזEɂ\zSoȀڍׂƒ׋ۂ₻̑ӎYɂ钰ǏזE̋@\̐CɁCSoÄُƒt[ُ̈ɂƂȂǂ̉ǂɂĉDǏזE͔SoA\z邱Ƃɂ蒰׋ۂ𐧌䂵CɁC׋ۂ̎hɂSoA͐nC܂CǏזE͒׋ۂ̎hƉuSזEɓ`B邱Ƃɂ蒰ǖƉun̐SDᇐ咰N[aƂǐɂẮCaɂďXɉ𖾂͐ił̂̈ˑRƂĕsȓ_DƂɁCᇐ咰ɂĂ͂̕aƂĔSoÄُ킪ڂĂDSoA̋@\C܂CǏזEƒ׋ۂƂ̑ݍp̉𖾂ɐiނƂɂCǐ̕aѕaԂ̉𖾂ƂɂVȎÐ헪̊J҂D

<h2> </h2>
<ol>
<li id="R1"><span class='au'>Merga, Y., Campbell, B. J. & Rhodes, J. M.</span>: <span class="ti">Mucosal barrier, bacteria and inflammatory bowel disease: possibilities for therapy.</span> <span class='so'>Dig. Dis., 32, 475-483 (2014)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/24969297" target="_blank">PubMed</a>]</span></li>
<li id="R2"><span class='au'>Ayabe, T., Satchell, D. P, Wilson, C. L. et al.</span>: <span class="ti">Secretion of microbicidal -defensins by intestinal Paneth cells in response to bacteria.</span> <span class='so'>Nat. Immunol., 1, 113-118 (2000)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/11248802" target="_blank">PubMed</a>]</span></li>
<li id="R3"><span class='au'>Sato, T., van Es, J. H, Snippert, H. J. et al.</span>: <span class="ti">Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.</span> <span class='so'>Nature, 469, 415-418 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21113151" target="_blank">PubMed</a>]</span></li>
<li id="R4"><span class='au'>Saia, R. S., Mestriner, F. L., Bertozi, G. et al.</span>: <span class="ti">Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages.</span> <span class='so'>Mediators Inflamm., 2014, 896029 (2014)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/25125801" target="_blank">PubMed</a>]</span></li>
<li id="R5"><span class='au'>Gerbe, F., Sidot, E., Smyth, D. J. et al.</span>: <span class="ti">Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites.</span> <span class='so'>Nature, 529, 226-230 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26762460" target="_blank">PubMed</a>]</span></li>
<li id="R6"><span class='au'>von Moltke, J., Ji, M., Liang, H. E. et al.</span>: <span class="ti">Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.</span> <span class='so'>Nature, 529, 221-225 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26675736" target="_blank">PubMed</a>]</span></li>
<li id="R7"><span class='au'>Howitt, M. R., Lavoie, S., Michaud, M. et al.</span>: <span class="ti">Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.</span> <span class='so'>Science, 351, 1329-1333 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26847546" target="_blank">PubMed</a>]</span></li>
<li id="R8"><span class='au'>Hase, K., Kawano, K., Nochi, T. et al.</span>: <span class="ti">Uptake through glycoprotein 2 of FimH<sup>+</sup> bacteria by M cells initiates mucosal immune response.</span> <span class='so'>Nature, 462, 226-230 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19907495" target="_blank">PubMed</a>]</span></li>
<li id="R9"><span class='au'>Rubino, S. J., Geddes, K. & Girardin, S. E.</span>: <span class="ti">Innate IL-17 and IL-22 responses to enteric bacterial pathogens.</span> <span class='so'>Trends Immunol., 33, 112-118 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22342740" target="_blank">PubMed</a>]</span></li>
<li id="R10"><span class='au'>Cash, H. L., Whitham, C. V., Behrendt, C. L. et al.</span>: <span class="ti">Symbiotic bacteria direct expression of an intestinal bactericidal lectin.</span> <span class='so'>Science, 313, 1126-1130 (2006)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16931762" target="_blank">PubMed</a>]</span></li>
<li id="R11"><span class='au'>Vaishnava, S., Yamamoto, M., Severson, K. M. et al.</span>: <span class="ti">The antibacterial lectin RegIII promotes the spatial segregation of microbiota and host in the intestine.</span> <span class='so'>Science, 334, 255-258 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21998396" target="_blank">PubMed</a>]</span></li>
<li id="R12"><span class='au'>Johansson, M. E., Philipson, M., Petersson, J. et al.</span>: <span class="ti">The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 105, 15064-15069 (2008)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21327117" target="_blank">PubMed</a>]</span></li>
<li id="R13"><span class='au'>Okumura, R., Kurakawa, T., Nakano, T. et al.</span>: <span class="ti">Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia.</span> <span class='so'>Nature, 532, 117-121 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/27027293" target="_blank">PubMed</a>] [<a href="http://first.lifesciencedb.jp/archives/12339" target="_blank">V_r[</a>]</span></li>
<li id="R14"><span class='au'>Yano, J. M., Yu, K., Donaldson, G. P. et al.</span>: <span class="ti">Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.</span> <span class='so'>Cell, 161, 264-276 (2015)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/25860609" target="_blank">PubMed</a>]</span></li>
<li id="R15"><span class='au'>Kamada, N., Kim, Y. G., Sham, H. P. et al.</span>: <span class="ti">Regulated virulence controls the ability of a pathogen to compete with the gut microbiota.</span> <span class='so'>Science, 336, 1325-1329 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22582016" target="_blank">PubMed</a>] [<a href="http://first.lifesciencedb.jp/archives/4813" target="_blank">V_r[</a>]</span></li>
<li id="R16"><span class='au'>Kitajima, S., Morimoto, M., Sagara, E. et al.</span>: <span class="ti">Dextran sodium sulfate-induced colitis in germ-free IQI/Jic mice.</span> <span class='so'>Exp. Anim., 50, 387-395 (2001)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/11769541" target="_blank">PubMed</a>]</span></li>
<li id="R17"><span class='au'>Ivanov, I. I., Atarashi, K., Manel, M. et al.</span>: <span class="ti">Induction of intestinal Th17 cells by segmented filamentous bacteria.</span> <span class='so'>Cell, 139, 485-498 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19836068" target="_blank">PubMed</a>]</span></li>
<li id="R18"><span class='au'>Atarashi, K., Tanoue, T., Ando, M. et al.</span>: <span class="ti">Th17 cell induction by adhesion of microbes to intestinal epithelial cells.</span> <span class='so'>Cell, 163, 367-380 (2015)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26411289" target="_blank">PubMed</a>]</span></li>
<li id="R19"><span class='au'>Atarashi, K., Nishimura, J., Shima, T. et al.</span>: <span class="ti">ATP drives lamina propria T<sub>H</sub>17 cell differentiation.</span> <span class='so'>Nature, 455, 808-812 (2008)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/18716618" target="_blank">PubMed</a>]</span></li>
<li id="R20"><span class='au'>Kusu, T., Kayama, H., Kinoshita, M. et al.</span>: <span class="ti">Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine.</span> <span class='so'>J Immunol, 190, 774-783 (2013)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/23241884" target="_blank">PubMed</a>]</span></li>
<li id="R21"><span class='au'>Wlodarska, M., Thaiss, C. A, Nowarski, R. et al.</span>: <span class="ti">NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.</span> <span class='so'>Cell, 156, 1045-1059 (2014)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/24581500" target="_blank">PubMed</a>]</span></li>
<li id="R22"><span class='au'>He, B., Xu, W., Santini, P. A. et al.</span>: <span class="ti">Intestinal bacteria trigger T cell-independent immunoglobulin A<sub>2</sub> class switching by inducing epithelial-cell secretion of the cytokine APRIL.</span> <span class='so'>Immunity, 26, 812-826 (2007)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17570691" target="_blank">PubMed</a>]</span></li>
<li id="R23"><span class='au'>Shimada, Y., Kinoshita, M., Harada, K. et al.</span>: <span class="ti">Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon.</span> <span class='so'>PLoS One, 8, e80604 (2013)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/24278294" target="_blank">PubMed</a>]</span></li>
<li id="R24"><span class='au'>Venkatesh, M., Mukherjee, S., Wang, H. et al.</span>: <span class="ti">Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.</span> <span class='so'>Immunity, 41, 296-310 (2014)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/25065623" target="_blank">PubMed</a>]</span></li>
<li id="R25"><span class='au'> Van der Sluis, M., De Koning, B. A., De Bruijn, A. C. et al.</span>: <span class="ti">Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.</span> <span class='so'>Gastroenterology, 131, 117-129 (2006)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16831596" target="_blank">PubMed</a>]</span></li>
<li id="R26"><span class='au'>Fu, J., Wei, B., Wen, T. et al.</span>: <span class="ti">Loss of intestinal core 1-derived <em>O</em>-glycans causes spontaneous colitis in mice.</span> <span class='so'>J. Clin. Invest., 121, 1657-1666 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21383503" target="_blank">PubMed</a>]</span></li>
<li id="R27"><span class='au'>Elinav, E., Strowig, T., Kau, A. L. et al.</span>: <span class="ti">NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.</span> <span class='so'>Cell, 145, 745-757 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21565393" target="_blank">PubMed</a>]</span></li>
<li id="R28"><span class='au'>Araki, A., Kanai, T., Ishikura, T. et al.</span>: <span class="ti">MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis.</span> <span class='so'>J. Gastroenterol., 40, 16-23 (2005)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15692785" target="_blank">PubMed</a>]</span></li>
<li id="R29"><span class='au'>Kobayashi, K. S., Chamaillard, M., Ogura, Y. et al.</span>: <span class="ti">Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.</span> <span class='so'>Science, 307, 731-734 (2005)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15692051" target="_blank">PubMed</a>]</span></li>
<li id="R30"><span class='au'>Biswas, A., Liu, Y. J., Hao, L. et al.</span>: <span class="ti">Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 107, 14739-14744 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20679225" target="_blank">PubMed</a>]</span></li>
<li id="R31"><span class='au'>Takahashi, D., Hase, K., Kimura, S. et al.</span>: <span class="ti">The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice.</span> <span class='so'>Gastroenterology, 141, 621-632 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21669204" target="_blank">PubMed</a>]</span></li>
</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">  iRyu Okumuraj</span>
F2016N ww@wnȂɂĔm擾CNww@wn D
e[}F咰ɂSoA̋@\D
Fbw̌珬Â֍vD

<strong>|c  iKiyoshi Takedaj</strong>
ww@wn D
URLF<a href="http://www.med.osaka-u.ac.jp/pub/ongene/" target="_blank">http://www.med.osaka-u.ac.jp/pub/ongene/</a>
</div>
? 2016  E|c  Licensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
