AN`_o`B̐VȐ@\

<strong> ^<sup>1</sup>E؏Gi<sup>2</sup></strong>
i<sup>1</sup>ww@ABw q`ẅC<sup>2</sup>Ɉȑw UwuזEwj
emailF<a href="mailto:makosato@anat2.med.osaka-u.ac.jp"> ^</a>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
̈Zr[, <strong>5</strong>, e011 (2016)@<a href="http://dx.doi.org/10.7875/leading.author.5.e011">DOI: 10.7875/leading.author.5.e011</a>
Makoto Sato & Hideshi Yagi: <strong>Filip acts as a novel meta-regulator for actin binding proteins, Filamin A and myosin II, and controls neurotransmission.</strong>

<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/11/Sato-5.e011-PDF.pdf" target="_blank"><img class="size-full wp-image-112 alignright" title="Download PDF" src="/images/downloadPDF.png" alt="Download PDF" width="100" height="20" /></a>
<p>
<p>
<p>
<p>
<p>
<!--more-->

<h2>v </h2>
@זĚ`Ԃ^SזEi̎vȍ\^pNłAN`́C100傫AN`^pNɂ萧CזEPʂƂ鐶̊ՂSDǂƂ̊֘A񍐂Ă^pNFiliṕC]̌`ɂăAN`^pNłFilamin Aƌj[̈ړ`Ԃ̐ɂDĈɂẮCFilip͓AN`^pNł~IVIIƋCƂɋVivX\XpČ`ԂɂC_o`B𐧌䂷D]ɂăAN`^pN^䂷VXȇ݂肳邪CFilip͂̂ЂƂƂĂ͂炢Ă\lD

<h2>͂߂</h2>
@qg̔]͐i̋ɂ݂ƂDȂČ͐wIɂ͐młȂDqg̔]ɂȐƐiIɗގ镔邵CۂɁC{\ƒm͈قȂ_oHɂƂÂ͂炭D]͐îтɌÂɐVȋ@\SĔBɂ̂łDł́CVȋ@\SƂ͂ǂH@̑\Iȕʂ̂ЂƂ]玿ł낤D]玿͑]̕\ʂ̌킸mm̃j[ɏWςƂłCj[̑傫▧ẍقȂ6w̍\ȂD]SɂƂƁCԂ̕ɑ̂]玿łD݂łC]玿\j[̎ނ͊Sɂ͊m肳Ă炸C̋@\̉𖾂͓Ȃ΂łDC]玿̌`̉ߒ͓IłĈ悻̘gg݂킩ĂDȂ킿C]玿̑啔߂鋻̃j[̑͑]玿̊OC[̔]̎͂ɂĎYC]玿ւƖ@̕Ɉړđw\zD
@ŋ߂̃Qm̐iɂCǂ⎩XyNgǂȂǂ̐_炷`qєǊ֘A`q񍐂Ă邪C̕a͗ގD́C̃^pN̂Ȃ炩̋ʂ̎ۂC`q̂ꂩ͂炩ȂƓl̏QƍlƂ܂Dŋ߂ɂȂCǂɂ`q̑_ǒ`Ɋ֘AƂ̕񍐂ȂĂ<a href="#R1"><sup>1,2)</sup></a>Dł́C̃^pN蓯悤ȏQN邱Ƃ肤̂H@肤Ƃ΁C͐_ǒ`ɂǂ̂悤ȏoȂ̂H@M҂́C̏ôЂƂj[̈ړɂƂߌi߂ĂD

<h2>1D@̕ւ̃j[̈ړ</h2>
@]玿̖7`8߂O^~__o`BƂ鋻̃j[́Cِɑ]玿̉Ő[̔]тɂĎYC@̕CȂ킿C\wɂނCő]玿\zD̃j[̈ړˏړiradial migrationjƂԁDˏړɂẮCזÊ]тɂ_oˋN]̕\ʂւƐL΂ˏOAזEdvȖSD]т͂Ȃꂽj[͂΂炭ړ̂CˏOAזE̓ˋNɏ邩ŁC΁C̐_oˋN[ƂĎg@̕ɈړDȂ݂ɁCqgɂĂ͑]玿̑2wё3wiwj̃j[̑Ƃiɂ傫ȓłDނɂĂ͑]̍Ő[݂̂ɕˏOAזE݂邪CqgɂĂ̓j[̈ړ̓rɂO]тɂOˏOAזEƂ΂ˏOAזE݂CƂɑ]玿̌`̌ɂāCO]тɂĎYꂽj[OˏOAזE̓ˋN[Ƃړւđ]玿̐w̃j[ɂȂ<a href="#R3"><sup>3)</sup></a>i<a href="#F1">}1</a>jD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@]т@̕Ɉړj[ɂ]玿̍\z</strong>
]тɂĎYꂽj[́CˏOAזE̓ˋN[ƂĔ]̕\ʂɂނĖ@̕ɏ̑]玿̈ʒu܂ňړDqgɂẮCj[̈ړ̓rɂO]тɂĂj[YC]玿̌`̌ɂĊOˏOAזE̓ˋN[ƂĈړC̑]玿̐w̃j[ɂȂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/11/Sato-5.e011-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2016/11/Sato-5.e011-Fig.1.png&amp;caption=fig1-caption-text]


<h2>2DˏړFilamin AFilip</h2>
@ˏړ̏Qɂ鎾ƂĔ]͌ߐُDCʗ͏ɔǂ邱ƂmD͂d玿̂ЂƂłCʏ̑]玿ɂ킦j[̂܂肪]̐[̔]̎͂ɔF߂邱ƂłD̃j[̂܂́C{͔]̎͂]̕\ʂɂނړׂj[ړłɏWς̂ƍlDāC̎ɂĂFilamin A̕ψق񍐂Ă<a href="#R4"><sup>4)</sup></a>DFilamin AXF̂ɃR[hAN`^pNłi<a href="#F2">}2</a>jDɂẮC2{XF̂̂זEƂɂꂩs͂炭D2{XF̂̂CψقFilamin AR[hXF̂̂͂炭񔼐̃j[]̎͂̔]тړȂƂƁC̕a܂DāC̎Filamin Aj[̈ړɌƂ̂łȂ^pNł؍ƍlD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@Filamin A̍\</strong>
N[ɂ̓AN`ʂDC[ő݂ɌCʏ͓ʑ̂ƂĂ͂炭D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/11/Sato-5.e011-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2016/11/Sato-5.e011-Fig.2.png&amp;caption=fig2-caption-text]

@Filamin A̓^pNyf̂ЂƂłJpCɂ蕪邪C̕Filamin A̋@\̐ɂďdvłDM҂́CFilamin AƌJpCɂFilamin A̕𑣐i^pNCȂ킿Cj[ɂFilamin A̗ʂ𐧌䂵j[̈ړшړ̓ř`Ԃ𐧌䂷^pNƂāCbgɂFilip𓯒肵<a href="#R5"><sup>5,6)</sup></a>D܂C}EXɂFilipmbNAEgƁC]玿̑2wё3w̓̃j[̔zuɈُ킪F߂ꂽ<a href="#R7"><sup>7)</sup></a>DȂCqgɂI[\OFilip1Ƃĕ񍐂ĂD
@bgɂFilamin AmbNAEgƃj[̈ړɏQF߂邪<a href="#R8"><sup>8)</sup></a>C}EXɂĂ̓j[̈ړɊւăqgƓlȈُ͔F߂Ȃƕ񍐂Ă<a href="#R9"><sup>9)</sup></a>DFilamin A̕ψقɂ\^͑ɂ킽CxgDCABn̑gDCëُȂǂm邪<a href="#R10"><sup>10)</sup></a>Cj[̈ړ΁CFilamin AmbNAEg}EX̕\^ƃqg̊҂̕\^͗ގƂDł́CȂ_onɂāCqgуbgƃ}EXƂ̂ŕ\^قȂ̂낤D̗RƂāCFilamin Aɑ΂⑫Iɋ@\t@~[^pNłFilamin BFilamin C̎̂ɂ锭̗l̈ႢCqgɂĔF߂O]тɂĎYj[bgƃ}EXł͈قȂ\Cɂ́C̃j[ɂFilamin Â͂炫̏dv̈ႢȂǂz肳DC͂m肵̂ł͂ȂDȂM҂́CFilipmbNAEg}EXɂĂ݂̂ꂪȓ̃j[̏Wc̑]玿ɂzu̕ψقώ@Ă<a href="#R7"><sup>7)</sup></a>C񂷂Ɣʂɂl̕ωFilamin AmbNAEg}EX̔]ɂĂĂ\͔ےłȂƍlĂD

<h2>3DFilip^pNƂẴ~IVIIb</h2>
@]̌`Ƃ͈قȂCnɂƂȂFilamin A̔]ɂ锭ʂ͑傫<a href="#R11"><sup>11)</sup></a>D̂̔]ɂẮCǓזEFilamin A̔ʂِ͑ɔׂ킸ƂD̂̃j[ɂFilamin A̔F߂ꂽƂ̕񍐂͂̂́C_o`B̏łXpCiˋNjɂ锭͖mɂ͔F߂Ȃ<a href="#R12"><sup>12)</sup></a>DŁCFilip͐̂ɂĂF߂DŕM҂́CFilip͐̂ɂFilamin AȊÕ^pN@\Ƒz肵CFilipƌ^pNTĎʁCAN`^pNł~IVIIb肳ꂽ<a href="#R11"><sup>11)</sup></a>D

<h2>4DAN`ۂт̌^pN</h2>
@ŁCAN`ۂт̌^pNɂĊȒPɂ܂Ƃ߂ĂDAN`ۂ͍זĚ`ԂזEɂ镪qԂ̐̎vȒSłCǂђԌatBgƂƂɍזEi\D_onɂẮC_o`B̏łVivXCƂɁCVivXłXpČ`Ԃê̓ԂɂC]̌`̍ۂɂ̓j[̈ړ₻̂̂̐_oȞ`ɂČƂ̂łȂS<a href="#R13"><sup>13)</sup></a>DזEɂẮCAN`ۂ͂܂܂Ȍ`Ƃ͂炭DƂ΁Cۂsɉ{W܂AN`ۂ́CזEɂĂ͔Oт̍i\CړזEɂĂ͂̑Oʂɂ݂鎅󉼑𗠑łDCۂǂԖڏɂȂꍇɂ́CAN`ۂ͍זËړɏdvȗt󉼑̗ł\ƂĂ̖͂Ď`̕ώCAN`ۂɌCAN`^pNɂ炳D160ȏ̃AN`^pNmĂCAN`̏dђEdɂ^pNCAN`ۂ̕}ɂ^pNCAN`ۂ̑ɂ^pNCAN`ۂ̉ˋɂ^pNCAN`ۂƖ^pNƂ̌ɂ^pNCAN`ۂ̈艻ɂ^pNCAN`ۂƔǂƂ̌ɂ^pNȂǁCɂ킽<a href="#R14"><sup>14)</sup></a>D
@Ƃ悭mꂽAN`^pN̓~IVł낤D~IV͍i؍זEɂăAN`ۂƋ؎kЂNDʂɁC~IVN[ɂ̓AN`ƌATP̉wbhhC<a href="#R15"><sup>15)</sup></a>DATP̉ɂGlM[𓾂āC~IV̓AN`ۂ̂ړD~IVɂ13镪q킪݂邪<a href="#R16"><sup>16)</sup></a>C@\̉͂̐ił鉡؂̋،ۂ\~IV̓~IVIIɑD~IVII͏dCyCK{yꂼ2{Cv6̃TujbgdZʑ̂ƂĂ͂炭i<a href="#F3">}3</a>jDɁC̘Zʑ݂̂͑ɏdă~IVۂ`DؓזEɂ~IVIIF߂Cؓ^̃~IVIIȂ~IVۂƓlɔؓ^̃~IVȂ~IVۂɂ̗[ɃwbhhC݂DāC[ꂼŃAN`ۂƌCATPɂ藼[ɌAN`ۂǂ߂Â邱ƂłD̍pɂCؓ^̃~IVII͍זÊ܂܂ȊɉčזĚ`Ԃ𐧌䂷<a href="#R17"><sup>17)</sup></a>D

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@~IVII̍\</strong>
dCyCK{yꂼ2{ȂZʑ̂ƂĂ͂炭DdN[̃wbhhCɂATPasehCуAN`ʂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/11/Sato-5.e011-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2016/11/Sato-5.e011-Fig.3.png&amp;caption=fig3-caption-text]

@~IVƂȂђĂAN`^pNłFilamin A̓AN`ۂǂ̉ˋɂi<a href="#F4">}4a</a>jDFilamin A͂N[ŃAN`ۂƌCʑ̂`邱ƂɂAN`ۂˋ<a href="#R18"><sup>18)</sup></a>D̉ˋɂCAN`ۂ͖Ԗڏ̍\ƂQɂȂD̃Q̍\͍זEړۂɌ`t󉼑̓ɂĂ΂ΔF߂CזËړɂďdvȋ@\͂D܂CFilamin Aɂ͂܂܂ȍזEVOi`Bɂ^pN邱ƂmĂC^pNƂĂ͂炭<a href="#R10"><sup>10)</sup></a>i<a href="#F4">}4b</a>jD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@Filamin A̋@\</strong>
iajʑ̂ȂFilamin A2̃AN`ۂƌAN`ۂǂˋD
ibjזE̋ߖTɂẮC܂܂ȃVOi`Bɂ^pN̑^pNƂĂ͂炭D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/11/Sato-5.e011-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2016/11/Sato-5.e011-Fig.4.png&amp;caption=fig4-caption-text]


<h2>5D~IVIIbƃj[̈ړѐ_o`B</h2>
@]ɂĔؓ^̃~IVIIזËړɂƂ<a href="#R19"><sup>19)</sup></a>DC]玿ɂj[̈ړɂӋ`ɂĂ͖mł͂ȂD]玿ɂ킪RȂ銊]ǂ͕̑ˏړ̏Q̂߂ƂCȏ̗Ⴊ<em>Lis1</em>`q̕ψقɂDLis1͒Ŝ̈ʒuъj̈ʒu̐ăj[̈ړɈُЂN<a href="#R20"><sup>20)</sup></a>Cŋ߂̌ɂāCLis1̓AN`у~IV̐ɂ֗^邱Ƃ炩ɂĂ<a href="#R21"><sup>21)</sup></a>D<em>Lis1</em>`q̕ψق̃weڍ̃}EXɂĂ͏]ɂj[̈ړɈُ킪F߂C̃j[ɂăAN`у~IV̐ɂᕪqGTPaseCƂRhoAĂ<a href="#R21"><sup>21)</sup></a>DʂɁCRhoA͔ؓ^̃~IVIICזEɌ`Ԃ̕ωЂNזËړɊ֗^<a href="#R22"><sup>22)</sup></a>DC~IVIIb̃mbNAEg}EXɂĂ͏]̒`ѓ̐_oj̈ʒüُ̂قɂ͔]ɂđ傫Ȉُ͔F߂Ȃ<a href="#R23"><sup>23)</sup></a>D̂ƂCؓ^̃~IVIIj[̈ړ̋@\ׂ͂Ẵj[ɋʂ̂ł͂Ȃ\D
@̂ɂă~IVIIb͐_o`BɂďdvȖ͂DזEɂL̊Ղ̂ЂƂƂ钷ɂẮCVivXʂłXpC̃VivX̖ʂɂê̐̕ωɂ킦CXpĈ̂̌`Ԃ̕ω̊ՂƂ邪Č`Ԃ̕ὠ~IVIIbɂƂ낪傫<a href="#R24"><sup>24-26)</sup></a>DnXpC͂̏㕔̑̐ς傫}bV[ľ`ԂC~IVIIb͂̊ɑǍ݂<a href="#R27"><sup>27)</sup></a>D~IVIIb̂͂炫}ƃXpČ`Ԃ͍גˋNlɂȂD~IVIIb̊x̕ωɂC炭̓AN`ۂC`ԂωƍlD

<h2>6DXpCɂFilipу~IVIIb</h2>
@Filip̓~IVIIbɑ΂ʂы@\2̖ʂŗ}Iɂ͂炭<a href="#R11"><sup>11)</sup></a>DFilipȂ|{זEFilip𔭌ƃ~IVIIb̗ʂDɁCFilipȂCñj[Filip𔭌ƁCXpC̊ɂă~IVIIbC܂C~IVIIb̋Ǎ݂ĂɔF߂XpC̐DFilipFilamin Aɑ΂ĂCa<sup>2+</sup>ˑveA[[̕𑣐i<a href="#R5"><sup>5)</sup></a>C~IVIIbɑ΂Ăގ@\ɂp\li<a href="#F5">}5</a>jD

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@Filip̃XpCɂ@\</strong>
iajFilip݂̑ȂXpCɂAN`ۂу~IVIIb̋Ǎ݁D
ibjFilip݂̑XpCɂAN`ہC~IVIIbCFilip̋Ǎ݁D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/11/Sato-5.e011-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2016/11/Sato-5.e011-Fig.5.png&amp;caption=fig5-caption-text]

@C~IVIIb̏dɂFilipƂ̌ʂɂČƂCN[̃AN`ʂATPasehC̋ߖTɂ<a href="#R11"><sup>11)</sup></a>DFilipƂ̌ɂ~IVIIbATPase̒ڂ̕ω͑肳ĂȂČʂATPaseɑ΂Ȃ炩̍pz肳邱ƁCāCFilip𔭌ȂCñj[Filip𔭌ۂ̃XpČ`Ԃ̕ωƁCATPasȇjQɂ~IVIȊjQ܂ƂĂ͂炭urX^`𓊗^ۂ̃XpČ`Ԃ̕ω悭ގƂ<a href="#R11"><sup>11)</sup></a>CFilip~IVIIbɑ΂ATPasejQp\͍ƍlDȂC~IVɂATPasejQƃAN`Ƃ̌QDɁCFilip̓~IVIIb̃AN`ʂ̋ߖTƌ邽߁C̏QɂAN`ƃ~IVIIb̌jQ\lD
@]ɂFilip̔͌ǓIłDO]ɂĂ͑]玿CȂłt玿Cɂ͝ĜȂǂ̕Ӊn̊֘Aʂѕ̂ɖĂȔF߂DCCnɔ͔F߂Ȃ<a href="#R11"><sup>11)</sup></a>D̎CXpC\^pN̑g͋ψł͂ȂƁĈ߁CXpC͔̐]̕ʂƂɈقȂ邱ƂD

<h2>7DFilipƐ_o`BюaƂ̊֘A</h2>
@Filip̓XpČ`Ԃ݂̂Ȃ炸XpCւNMDAê̋Ǎ݂ɂ<a href="#R11"><sup>11)</sup></a>DFilip𔭌Cñj[ɂẮCXpCɂNMDAê̋Ǎ݂ĎۂS@\̏ڍׂ͖炩ɂĂȂCˋNƃXpCȂXpC̊̖S\z肳DāCFilip̃mbNAEg}EXɂĔ]ɂ_o`Bώ@Ƃ傫ωĂ<a href="#R11"><sup>11)</sup></a>D
@CFilip͓ǂ̊҂̑OtɂĂ̔̓Ԃ傫ωĂCǂƂ̊֘AĂ<a href="#R1"><sup>1)</sup></a>DāCFilip݂̂Ȃ炸Cj[̈ړɂÃ^pNǂɊ֗^Ƃ񍐂Ă<a href="#R1"><sup>1)</sup></a>D́Cǂ̔ǂ͜늳ւ̐Ǝ㐫̐^̌]̌`邢͔B̒iKɂƂ̍l<a href="#R2"><sup>2)</sup></a> 𗠂ÂƂl邪CɁCFilipɑ\悤ɍזEi̐ɂ^pŃCɃj[̈ړɂ݂̂Ȃ炸CXpCɂזEi̐䂨тł̐_o`BƖڂɊ֌WD䂦C]̌`ƃXpCɂ_o`BSɓƗۂƂĈƂɂ͖Ĉ݂ɐƂ߂邱Ƃ͂ȈՉƂ悤D

<h2></h2>
@b͂􂷂邪Cؓ̑s̕ωƖڂɊ֌WgD̂ЂƂɓEDEU؂͓Ê܂𒼍sāi@̕ɁjCE؂͓Ê܂Ȃ悤Ɂiڐ̕ɁjD̈قȂ鑖s䂦ɁCؓ̎kłĂʂȂǂɉEg肷邱Ƃ\ɂȂDM҂́Cl݂̂XpC̊ɂĂzł̂łȂƍlĂDۂɁCAN`ۂу~IVۂ̃XpC̊ɂ鑖sƁC傫2ނ̗l悤łDȂ킿CVivX̖ʂɁCΏcɐLтۂƁC֏ɑۂłD̋@\IȈӋ`͈قȂ邱Ƃz肳邪C͖mɂ͂ȂĂȂDCۂ̑sƂɂɐ䂪Ă邩CƂɁCFilip2ނ̗l̐ۂƂ̘AւɂĂ͋[D
@Filip͐̂̔BiKɉCΌp[gi[ウĂ͂炭DȂ킿CFilamin Aj[̈ړ`Ԃ̐ɁC~IVIIbXpČ`Ԃѐ_o`B̐ɂD]CAN`^pN̏ʂœ邵݂ɂĂ͖mɂ͊TOĂȂCCFilip͂߂Ƃ^pN肪ƂāCזEi̐̃JXP[hmɗ悤ɂȂ邱Ƃ҂ĂDɁCp[gi[̑Iɂ́CPɃp[gi[̔ʂ̑ǂ݂̂Ȃ炸kȐ@\݂̑\͍Ƒz肳C̉𖾂҂ĂD

<h2> </h2>
<ol>
<li id="R1"><span class='au'>Gulsuner, S., Walsh, T., Watts, A. C. et al.</span>: <span class="ti">Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network.</span> <span class='so'>Cell, 154, 518-529 (2013)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/23911319" target="_blank">PubMed</a>]</span></li>
<li id="R2"><span class='au'>Walsh, T., McClellan, J. M., McCarthy, S. E. et al.</span>: <span class="ti">Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia.</span> <span class='so'>Science, 320, 539-543 (2008)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/18369103" target="_blank">PubMed</a>]</span></li>
<li id="R3"><span class='au'>Hansen, D. V., Lui, J. H., Parker, P. R. et al.</span>: <span class="ti">Neurogenic radial glia in the outer subventricular zone of human neocortex.</span> <span class='so'>Nature, 464, 554-561 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20154730" target="_blank">PubMed</a>]</span></li>
<li id="R4"><span class='au'>Fox, J. W., Lamperti, E. D., Eksioglu, Y. Z. et al.</span>: <span class="ti">Mutations in <em>filamin 1</em> prevent migration of cerebral cortical neurons in human periventricular heterotopia.</span> <span class='so'>Neuron, 21, 1315-1325 (1998)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/9883725" target="_blank">PubMed</a>]</span></li>
<li id="R5"><span class='au'>Nagano, T., Yoneda, T., Hatanaka, Y. et al.</span>: <span class="ti">Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone.</span> <span class='so'>Nat. Cell Biol., 4, 495-501 (2002)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/12055638" target="_blank">PubMed</a>]</span></li>
<li id="R6"><span class='au'>Nagano, T., Morikubo, S. & Sato, M.</span>: <span class="ti">Filamin A and FILIP (filamin A-interacting protein) regulate cell polarity and motility in neocortical subventricular and intermediate zones during radial migration.</span> <span class='so'>J. Neurosci., 24, 9648-9657 (2004)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15509752" target="_blank">PubMed</a>]</span></li>
<li id="R7"><span class='au'>Yagi, H., Oka, Y., Komada, M. et al.</span>: <span class="ti">Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex.</span> <span class='so'>Neurosci. Lett., 612, 18-24 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26655467" target="_blank">PubMed</a>]</span></li>
<li id="R8"><span class='au'>Carabalona, A., Beguin, S., Pallesi-Pocachard, E. et al.</span>: <span class="ti">A glial origin for periventricular nodular heterotopia caused by impaired expression of Filamin-A.</span> <span class='so'>Hum. Mol. Genet., 21, 1004-1017 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22076441" target="_blank">PubMed</a>]</span></li>
<li id="R9"><span class='au'>Feng, Y., Chen, M. H., Moskowitz, I. P. et al.</span>: <span class="ti">Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 103, 19836-19841 (2006)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17172441" target="_blank">PubMed</a>]</span></li>
<li id="R10"><span class='au'>Feng, Y. & Walsh, C. A.</span>: <span class="ti">The many faces of filamin: a versatile molecular scaffold for cell motility and signalling.</span> <span class='so'>Nat. Cell Biol., 6, 1034-1038 (2004)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15516996" target="_blank">PubMed</a>]</span></li>
<li id="R11"><span class='au'>Yagi, H., Nagano, T., Xie, M. J. et al.</span>: <span class="ti">Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation.</span> <span class='so'>Sci. Rep., 4, 6353 (2014)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/25220605" target="_blank">PubMed</a>]</span></li>
<li id="R12"><span class='au'>Noam, Y., Phan, L., McClelland, S. et al.</span>: <span class="ti">Distinct regional and subcellular localization of the actin-binding protein filamin A in the mature rat brain.</span> <span class='so'>J. Comp. Neurol., 520, 3013-3034 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22434607" target="_blank">PubMed</a>]</span></li>
<li id="R13"><span class='au'>Luo, L.</span>: <span class="ti">Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity.</span> <span class='so'>Annu. Rev. Cell Dev. Biol., 18, 601-635 (2002)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/12142283" target="_blank">PubMed</a>]</span></li>
<li id="R14"><span class='au'>dos Remedios, C. G., Chhabra, D., Kekic, M. et al.</span>: <span class="ti">Actin binding proteins: regulation of cytoskeletal microfilaments.</span> <span class='so'>Physiol. Rev., 83, 433-473 (2003)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/12663865" target="_blank">PubMed</a>]</span></li>
<li id="R15"><span class='au'>Sellers, J. R.</span>: <span class="ti">Myosins: a diverse superfamily.</span> <span class='so'>Biochim. Biophys. Acta, 1496, 3-22 (2000)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/10722873" target="_blank">PubMed</a>]</span></li>
<li id="R16"><span class='au'>Foth, B. J., Goedecke, M. C. & Soldati, D.</span>: <span class="ti">New insights into myosin evolution and classification.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 103, 3681-3686 (2006)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16505385" target="_blank">PubMed</a>]</span></li>
<li id="R17"><span class='au'>Vicente-Manzanares, M., Ma, X., Adelstein. R. S. et al.</span>: <span class="ti">Non-muscle myosin II takes centre stage in cell adhesion and migration.</span> <span class='so'>Nat. Rev. Mol. Cell Biol., 10, 778-790 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19851336" target="_blank">PubMed</a>]</span></li>
<li id="R18"><span class='au'>van der Flier, A. & Sonnenberg, A.</span>: <span class="ti">Structural and functional aspects of filamins.</span> <span class='so'>Biochim. Biophys. Acta, 1538, 99-117 (2001)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/11336782" target="_blank">PubMed</a>]</span></li>
<li id="R19"><span class='au'>Solecki, D. J., Trivedi, N., Govek, E. E. et al.</span>: <span class="ti">Myosin II motors and F-actin dynamics drive the coordinated movement of the centrosome and soma during CNS glial-guided neuronal migration.</span> <span class='so'>Neuron, 63, 63-80 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19607793" target="_blank">PubMed</a>]</span></li>
<li id="R20"><span class='au'>Tsai, J. W., Bremner, K. H. & Vallee, R. B.</span>: <span class="ti">Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue.</span> <span class='so'>Nat. Neurosci., 10, 970-979 (2007)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17618279" target="_blank">PubMed</a>]</span></li>
<li id="R21"><span class='au'>Sudarov, A., Gooden, F., Tseng, D. et al.</span>: <span class="ti">Lis1 controls dynamics of neuronal filopodia and spines to impact synaptogenesis and social behaviour.</span> <span class='so'>EMBO Mol. Med., 5, 591-607 (2013)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/23483716" target="_blank">PubMed</a>]</span></li>
<li id="R22"><span class='au'>Kolega, J.</span>: <span class="ti">Asymmetric distribution of myosin IIB in migrating endothelial cells is regulated by a rho-dependent kinase and contributes to tail retraction.</span> <span class='so'>Mol. Biol. Cell, 14, 4745-4757 (2003)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/12960430" target="_blank">PubMed</a>]</span></li>
<li id="R23"><span class='au'>Ma, X., Kawamoto, S., Hara, Y. et al.</span>: <span class="ti">A point mutation in the motor domain of nonmuscle myosin II-B impairs migration of distinct groups of neurons.</span> <span class='so'>Mol. Biol. Cell, 15, 2568-2579 (2004)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15034141" target="_blank">PubMed</a>]</span></li>
<li id="R24"><span class='au'>Ryu, J., Liu, L., Wong, T. P. et al.</span>: <span class="ti">A critical role for myosin IIb in dendritic spine morphology and synaptic function.</span> <span class='so'>Neuron, 49, 175-182 (2006)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16423692" target="_blank">PubMed</a>]</span></li>
<li id="R25"><span class='au'>Rex, C. S., Gavin, C. F., Rubio, M. D. et al.</span>: <span class="ti">Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation.</span> <span class='so'>Neuron, 67, 603-617 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20797537" target="_blank">PubMed</a>]</span></li>
<li id="R26"><span class='au'>Hodges, J. L., Newell-Litwa, K., Asmussen, H. et al.</span>: <span class="ti">Myosin IIb activity and phosphorylation status determines dendritic spine and post-synaptic density morphology.</span> <span class='so'>PLoS One, 6, e24149 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21887379" target="_blank">PubMed</a>]</span></li>
<li id="R27"><span class='au'>Hotulainen, P. & Hoogenraad, C. C.</span>: <span class="ti">Actin in dendritic spines: connecting dynamics to function.</span> <span class='so'>J. Cell Biol., 189, 619-629 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/xxx" target="_blank">PubMed</a>]</span></li>
</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">  ^iMakoto Satoj</span>
F1991N ww@wȔmے CCN ww C1994N sww C1998N ȑw oāC2013Nww@ABw D
e[}F]玿̌`ɂ镪q@\эזE@\C_o̔Bɂ镪q@\эזE@\D
Fj[Rs[^[̐ECۂ̔]̑ΏۂƂẅ̗ւƃVtg܂Dz͂邩ɂ邵݂ł͂炭]̓C̎ŏłׂɋ΂ł܂D킹āCꂽmxbhTChւƉpł̂邱ƂĂ܂D
URLF<a href="http://www.anat2.med.osaka-u.ac.jp/" target="_blank">http://www.anat2.med.osaka-u.ac.jp/</a>

<strong> GiiHideshi Yagij</strong>
F1998N ww@wȔmے CCN ȑw C2009N  yC2011N Ɉȑw yoāC2015N  D
e[}F_onɂčזĚ`Ԃ𐧌䂷@\D
F_onɂזĚ`ԂƋ@\̊֌WɂāCC𖾂ĂD
URLF<a href="http://www.hyo-med.ac.jp/faculty/course/anatomy1.html" target="_blank">http://www.hyo-med.ac.jp/faculty/course/anatomy1.html</a>
</div>
? 2016  ^E؏Gi Licensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
