z펾ɂAfB|TCGX̏dv

<strong>勴_EL</strong>
iÉww@wn qSǕawuj
emailF<a href="mailto:ohashik@med.nagoya-u.ac.jp">勴_</a>C<a href="mailto:nouchi@med.nagoya-u.ac.jp">L</a></a>
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̈Zr[, <strong>4</strong>, e004 (2015)@<a href="http://dx.doi.org/10.7875/leading.author.4.e004">DOI: 10.7875/leading.author.4.e004</a>
Koji Ohashi & Noriyuki Ouchi: <strong>Recent progress in adiposcience for the cardiovascular system.</strong>

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<h2>v </h2>
@bgD̓AfB|TCgJCƑ̂鐶𕪔債ċߖT邢͉ȗɍp呟łDAfB|TCgJCƂăv`AfB|lN`ĂC얞ǂɂAfB|TCgJC̏dvɂĂƕ񍐂ĂDAfB|lN`͓ӂ̉Ppɂ킦CSǎɑ΂ĂړIȖhpC얞ԂɂAfB|lN`̔̒ቺz펾̐iWɂȂƍlĂDɍŋ߂ł́CSǌnɑ΂یIɍpAfB|TCgJC肳ĂDAfB|TCGX͏z펾̕aԂ̉𖾂ɂďdvłC̃r[ł́CSǌnɍpAfB|TCgJC̈Ӌ`ɂāCM҂̍ŋ߂̌ʂӂ߉D

<h2>͂߂</h2>
@ߐH^s琶얞CƂɓb̉ߏȒ~ς́C2^AaCCُЂNŏIIɐSǎɂ邪C̕q@ɂĂ͏\ɉ𖾂ĂȂDbgD̓AfB|TCgJCƑ̂鑽̐YCߖT邢͉ȗɂ܂܂ȉeyڂƂ炩ɂĂDAfB|TCgJCƂāCTNFitumor necrosis factor-Cᇉ󎀈qjCCRPiC-reactive proteinCC^pNjCC^[CL6CC^[CL18CMCP-1imonocyte chemoattractant protein-1jCAngptl-2iangiopoietin-like protein-2jCWX`ȂǁCǎNœӂSǎ𑝈̂CPAI-1iplasminogen activator inhibitor-1ĵ悤ɈՌ𐫂𑣐îmĂC̃AfB|TCgJC͔얞ƂƂɔ㏸i<a href="#F1">}1</a>jDCAfB|lN`̂悤ɁCRǐɂ͂炫ǎ܂ނ܂܂Ȕ얞֘Aɑ΂hIɍpAfB|TCgJCɂĂCߔNC񍐂Ăi<a href="#F1">}1</a>jDRǐ̃AfB|TCgJC͔̑얞ɂ茌ZxቺCRǐ̃AfB|TCgJC̔̒ቺƉǐ̃AfB|TCgJC̔̏㏸ƂAoX邱Ƃɂ얞֘A̐iWɂȂ邱Ƃ炩ɂĂĂD̃r[ł́CAfB|lN`ӂލRǐɂ͂炫SǎɖhIɍpAfB|TCgJCɂāCM҂̌𒆐SɉD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@b̒~ςƃAfB|TCgJC̐̏Q</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/04/Ouchi-4.e004-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2015/04/Ouchi-4.e004-Fig.1.png&amp;caption=fig1-caption-text]


<h2>1DAfB|lN`ƐSǎ</h2>
@AfB|lN`͎bgDɂĂƂʂ̑^pNƂāC1996NɈ`qN[jOꂽ<a href="#R1"><sup>1)</sup></a>DAfB|lN`͎bgD番傳ɂ炸ČZx͔얞wibody mass indexFBMIjb̖ʐςƗLӂȕ̑ւƂ񍐂Ă<a href="#R2"><sup>2)</sup></a>DAfB|lN`̌Zx́C얞ɂ킦C2^Aå҂ɂĂቺ邱Ƃ񍐂Ă<a href="#R3"><sup>3)</sup></a>DɁCSǎƂ̊֘AɂĂCɗLӂȋ󂪔F߂ꂽ̊҂͗LӂȒAfB|lN`ǂ<a href="#R4"><sup>4)</sup></a>D܂CAfB|lN`̌Zxl獂l܂4ɕČƂCق̊̊댯qɂ␳ƂłAfB|lN`ǌQł͐AfB|lN`ǌQƔrăIbY2.1{̊̊댯Ƃ炩ɂꂽ<a href="#R5"><sup>5)</sup></a>DāCAfB|lN`͊ɂLpȃoCI}[J[ɂȂ邱ƂꂽD
@AfB|lN`d̐iWɉeyڂƂ̃xł炩ɂĂDdf}EXłApoEmbNAEg}EXɃAfmECXxN^[păAfB|lN`ߏɔƂC哮Ǖǂɂ鎉bH̖ʐςLӂɌCזEڒqłVCAMCXJxW[eACTNF̒ቺƂȂ<a href="#R6"><sup>6)</sup></a>D܂CAfB|lN`̓}Nt@[WɍpCXJxW[eA̔ቺ邱ƂɂA}邱Ƃ炩ɂĂi<a href="#F2">}2</a>jDɁCAfB|lN`mbNAEg}EXp͂ł́CIȏł͌ǌnɈُ͔F߂ȂCApoEmbNAEg}EXƌzApoEƃAfB|lN`̃_umbNAEg}EX쐻Ƃ哮Ǖǂɂēd̑傪F߂CdւTזȄWςLӂɑĂ<a href="#R7"><sup>7)</sup></a>D

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@AfB|lN`ɂSǎɑ΂hp</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/04/Ouchi-4.e004-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2015/04/Ouchi-4.e004-Fig.2.png&amp;caption=fig2-caption-text]

@̉ǂ͓d̐iWɂĔɏdvȖ͂ĂDǔɂĒSIȖ͂}Nt@[WɊւẮCAfB|lN`͉ǐTCgJC̔}邱<a href="#R8"><sup>8)</sup></a>CRǃTCgJCłC^[CL10̔U邱ƂȂǂ񍐂Ă<a href="#R9"><sup>9)</sup></a>i<a href="#F2">}2</a>jDɁCAfB|lN`}Nt@[W̋ɐωC܂CTNFȂǂ̉ǐTCgJC𕪔債ǎNɂ͂炭M1}Nt@[WCC^[CL10Ȃǂ̍RǐTCgJC𕪔債RǓIɂ͂炭M2}Nt@[Wւ̕ϊU邱Ƃ񍐂Ă<a href="#R10"><sup>10,11)</sup></a>i<a href="#F2">}2</a>jD
@AfB|lN`ɂM2}Nt@[Wւ̓]̗ÚCAfB|lN`ê̂ЂƂłAdipoR2邱Ƃ񍐂Ă<a href="#R12"><sup>12)</sup></a>i<a href="#F2">}2</a>jDAdipoR1AdipoR2́C2003NɃAfB|lN`êƂē肳ꂽ^pNł<a href="#R13"><sup>13)</sup></a>D7񖌊ђʌ^̍\CmG^pN^ẽt@~[Ƃ͍\Iы@\IɈقȂt@~[ɑƍlĂD[ƂɁCAfB|lN`ɂM2}Nt@[Wւ̓]̗U͎bgD̎悵bזEȊỎ敪i}Nt@[WьǓזE╽؍זEȂǌǕǂ\זE܂ށjɂĂF߂ĂCAfB|lN`bgDɂ鉊ǂ̐ɂ֗^Ă\ꂽ<a href="#R10"><sup>10)</sup></a>D܂Cǂ̐ɂďdvł}Nt@[WɂA|g[VXזEÐH\ɑ΂CAfB|lN`iIɍpRǍp𔭊邱Ƃ񍐂Ă<a href="#R14"><sup>14)</sup></a>D̕q@\ƂāCAfB|lN`VȃAfB|lN`̎êƂē肳ꂽזE̕\ʂ̃JeBLɌCђʃhCCD91A_v^[^pNƂāCA|g[VXNĂזE݂₩ÐH邱Ƃ񍐂Ă<a href="#R14"><sup>14)</sup></a>i<a href="#F2">}2</a>jDȏC얞ԂɂāC}Nt@[WɂRǍpAfB|lN`̔̒ቺd̐iWɂȂ\ꂽD
@܂CAfB|lN`̋Sɑ΂یIȍpɂĂ炩ɂĂDAfB|lN`mbNAEg}EXɂĐSğ󗬃f쐻AfB|lN`̋Sɑ΂钼ړIȍpɂČƂCS؍[ǂ͈̔͂͗Lӂɑ傫CS؏Q̎wWłNA`Li[[ZxLӂɍl<a href="#R15"><sup>15)</sup></a>D̂ƂCAfB|lN`mbNAEg}EX̋SؑgDł͐S؍זẼA|g[VXщǔLӂɑĂDVebg̐S؍זEp<em>in vitro</em>ɂł́CAfB|lN`COX-2-PGE<sub>2</sub>VOi`BoHTNF̗̔}ɂRǍpƁCAMPLi[[VOiS؍זE̍RA|g[VXpɂCSǕیp𔭊邱Ƃꂽi<a href="#F2">}2</a>jD܂CAfB|lN`̓}EX̐Sğ󗬃fɂāCAdipoR1ƃJxI3Ƃ̂̕VOi`BoHTJhwVOi`BoHɂAMPLi[[SǕیp𔭊邱Ƃ񍐂Ă<a href="#R16"><sup>16,17)</sup></a>DTJhw̓AfB|lN`̎êƂē肳ꂽCђʃhCCǂ̂悤AMPLi[[VOîɂĂ͍̐ʂ҂D
@AfB|lN`mbNAEg}EXɂăAfmECXxN^[păAfB|lN`𔭌ƁC債S؍[ǂ͈̔͂LӂɌ쐶^̃}EXƓxɂ܂ŉP<a href="#R15"><sup>15)</sup></a>DɁCAfB|lN`mbNAEg}EXɑ哮kp{s׃f쐻ƂCS傪D̃}EXɃAfmECXxN^[ɂAfB|lN`𔭌ƁCS͗LӂɌ쐶^̃}EXƓxɂ܂ŉP<a href="#R18"><sup>18)</sup></a>D|{S؍זEtFjtŏ邱Ƃɂ萶S؍זE̔ɑ΂CAfB|lN`AMPLi[[VOiĖhIɍpi<a href="#F2">}2</a>jD܂CAfB|lN`͔|{S؍זẼA|g[VXZ~_[[̏㏸ɂXtBSV1-_̎Y̑}邱Ƃ񍐂Ă<a href="#R19"><sup>19)</sup></a>DAfB|lN`͒_fĎ_fQɂЂN|{S؍זẼA|g[VXɂĂC_XgXቺ邱Ƃɂ}邱Ƃ񍐂Ă<a href="#R20"><sup>20)</sup></a>DɁCOՏIȃu^̃fɂĂCğ󗬂̂ƂɃAfB|lN`ɒ邱ƂɂCS؍[ǂ͈̔͂͌S@\P邱ƂoĂ<a href="#R21"><sup>21)</sup></a>DCAfB|lN`ǂ͐S؂ɏQЂNCAfB|lN`̕[͓dS؂̏Qɑ΂hIɂ͂炭Ƃ炩ɂꂽDȏCAfB|lN`͋}S؍[ǂ̎Ö@̊JɂVȕWIƂȂ\ꂽD
@CSsS̊҂ɂĂ̓AfB|lN`̌Zx㏸ĂCAfB|lN`̌ZxȂقǗ\̑邱Ƃ񍐂Ă<a href="#R22"><sup>22)</sup></a>DCAfB|lN`mbNAEg}EX̍F邱ƂɂS؍[ǃf쐻ƂC4TԂ̂ɂ͐S@\LӂɑC̓AfmECXxN^[ɂAfB|lN`𔭌邱ƂɂLӂɉP<a href="#R23"><sup>23)</sup></a>DɁCAfB|lN`mbNAEg}EXɃhL\rV𓊗^邱ƂɂSsSf쐻ƂCS@\ɏdẍُC̓AfmECXxN^[ɂAfB|lN`𔭌邱ƂɂPꂽ<a href="#R24"><sup>24)</sup></a>D̓̌ʂCAfB|lN`SsS̐iWɑ΂hpCSsS̏ԂɂAfB|lN`̌Zx̏㏸͑㏞Iȕωł\ƂlꂽD
@SsS̊҂ɂăAfB|lN`̌Zx㏸镪q@\ƂāCS[igEAyv`h]igEAyv`hȂǃigEAyv`h̊֗^񍐂ĂDS[igEAyv`hє]igEAyv`h͐SsŜƂɐSōꕪ傳złCSsS̏dǉт̌ZxƂ͐̑ւƂ񍐂ĂDigEAyv`h͗Ap⌌ǊgpȂǋSǕیpCՏ̌ɂĂSsSÖƂėpĂDSsS̊҂ɂĂ̓AfB|lN`̌ZxƐ̑ւĂCϗʉ͂ɂĔ]igEAyv`h̓AfB|lN`̌Zx̓Ɨ\qł<a href="#R25"><sup>25)</sup></a>D܂Cqg|{bזEɐS[igEAyv`h邢͔]igEAyv`hYƃAfB|lN`̔㏸邱ƁCSsS̊҂ɐS[igEAyv`h𓊗^ƃAfB|lN`̌Zx㏸邱ƂĂDCSsŜƂ̍AfB|lN`ǂ́CSsŜƂɑANPS[igEAyv`hBNP]igEAyv`hɂAfB|lN`̕呣ipɂ\ꂽ<a href="#R26"><sup>26)</sup></a>D
@d̔ǂѐiWɂČǓ̏Q͔ɏdvȈqłDAfB|lN`mbNAEg}EXɂč쐻fɂĂ͌ǐVQĂ<a href="#R27"><sup>27)</sup></a>DC쐶^̃}EXɑ΂AfmECXxN^[ɂAfB|lN`ߏɔƌǐViꂽD̔̓h~iglKeBu^AMPLi[[̉ߏ蔭ɂ}ꂽƂCAfB|lN`ɂ錌Ǔ̕یpAMPLi[[ƍlꂽD܂C|{ǓזEɂāCAfB|lN`AMPLi[[ē^NOyf邱ƂɂCǐVɏdvȌǓזE̗VǗl\̌`𑣐iA|g[VX}邱Ƃ炩ɂꂽ<a href="#R28"><sup>28)</sup></a>i<a href="#F2">}2</a>jD܂C|{ǓזEɂsiRNAɂAdipoR1mbN_EƃAfB|lN`̓YɂAMPLi[[VOiubNꂽƂCAfB|lN`AdipoR1-AMPLi[[-^NOyfVOi`BoHČǓ̕یp𔭊\ꂽ<a href="#R29"><sup>29)</sup></a>D
@ɁCAfB|lN`͔|{ǓזEɂCOX-2̔㏸CPGI<sub>2</sub>̕𑣐i邱Ƃɂ茌Ǔ̕یp𔭊邱Ƃ炩ɂĂ<a href="#R29"><sup>29)</sup></a>i<a href="#F2">}2</a>jDǓɓٓICOX-2mbNAEg}EXɂĉf쐻ƁCǐVLӂɏQĂ<a href="#R29"><sup>29)</sup></a>DǓɓٓICOX-2mbNAEg}EXɂăAfmECXxN^[ɂAfB|lN`ߏɔƁCǐV̑ipF߂ꂸCAfB|lN`AMPLi[[VOiɂ킦CCOX-2-PGI<sub>2</sub>VOi`BoHČǓ̕یp𔭊邱ƂꂽD܂CAfB|lN`COX-2̔㏸镪q@\ƂẮCJeBLƂ̃A_v^[^pNłCD91PI3Li[[-AktVOi`Bn邱Ƃɂ邱Ƃꂽ<a href="#R29"><sup>29)</sup></a>D
@AfB|lN`ǂ͍ɂ֗^邱Ƃ񍐂ĂDuwIȌɂAfB|lN`ǂ͍̓Ɨ댯qł邱Ƃꂽ<a href="#R30"><sup>30)</sup></a>D܂CAfB|lN`mbNAEg}EXɍHH𕉉ׂ2TԂŗLӂȌ̏㏸<a href="#R31"><sup>31)</sup></a>CAfmECXxN^[ɂAfB|lN`𔭌ƍHHׂ̕ɂ錌̏㏸͔F߂ȂȂD܂C얞ѓAãfłKKAy}EX͏TƂƂɌ㏸邪CAfB|lN`ߏɔ邱Ƃɂ茌̏㏸͗}邱Ƃ炩ɂꂽ<a href="#R31"><sup>31)</sup></a>DAfB|lN`mbNAEg}EX͍HHׂ̕ɂCXR͐Ă炸Cǂѐtɂ^NOyf̔̒ቺ݂ꂽƂCAfB|lN`͌ǓɒړIɍpC^NOyf̊ɂNO̎Y㏸邱ƂŌ̏㏸}邱ƂꂽDȏ̂悤ɁCAfB|lN`̓}Nt@[WьǓזES؍זEƂSǂ\זEɑ΂C܂܂ȎêĒڂɍpCǂ̗}͂߂Ƃ\^𐧌䂷邱Ƃɂ葽ʂȐSǕیp𔭊ƍlꂽDCêVOi`BoHɂĂ͏\ɉ𖾂Ă炸CȂ錤ʂ҂D

<h2>2DCTRP9ƐSǎ</h2>
@CTRPiC1q/TNF-related proteinjt@~[^pN͕C1qɍ\ގC1qlhCуR[QhCCAfB|lN`ƍ\IɗގĂ邱ƂAfB|lN`pOɕނĂ<a href="#R32"><sup>32)</sup></a>DCTRP9CTRPt@~[^pN̂AfB|lN`ƃA~m_ƂCAfB|lN`ƓlCTRP9̌Zx͔얞f}EXɂĒቺ邱Ƃ񍐂Ă<a href="#R33"><sup>33)</sup></a>D܂CSğ󗬃fѐS؍[ǃfɂĂCTRP9̌Zx͒ቺ邱Ƃ񍐂Ă<a href="#R34"><sup>34,35)</sup></a>DS؏QfɂėVb_̌Zx㏸ĂCbgDɂ_XgX}[J[㏸Ă邱ƁC|{bזEɃp~`_H<sub>2</sub>O<sub>2</sub>Y邱ƂɂCTRP9̔ቺ邱ƂCCTRP9͔̔얞ɂĂS؏QɂĂl̋@ɂ萧䂳Ă\苻[<a href="#R34"><sup>34)</sup></a>D
@CTRP9͐Sǎɑ΂hIȍpƂ񍐂ĂD}EX̐Sğ󗬃fɂCTRP9̓^͐S؍[ǂ͈̔͂<a href="#R34"><sup>34)</sup></a>DSğ󗬂̂̂̐SgDɂĂAMPLi[[ɂ郊_̃xiĂ邪CCTRP9̓^AMPLi[[ɂ郊_̃xɘiD|{S؍זEpɂāCh~iglKeBu^AMPLi[[pAMPLi[[VOiubN邱ƂɂCTRP9ɂS؍זẼA|g[VX̗}ʂ͏ƂCCTRP9̓AfB|lN`ƓlAMPLi[[VOiĐSǕیp𔭊邱Ƃꂽi<a href="#F3">}3</a>jDɁCAdipoR1siRNAɂmbN_ECTRP9ɂAMPLi[[VOi̘ijQꂽƂCCTRP9͐S؍זEɂAdipoR1-AMPLi[[VOi`BoHĐSؕیp𔭊邱Ƃꂽ<a href="#R34"><sup>34)</sup></a>D܂C2^Aa}EXɂS؍[ǃfɂĂCCTRP9̓^͎_XgX}邱ƂɂSؕیp𔭊邱Ƃ񍐂Ă<a href="#R36"><sup>36)</sup></a>i<a href="#F3">}3</a>jD܂CǕǂɑ΂ẮCCTRP9̓^̓AfB|lN`ƓlAdipoR1-AMPLi[[-^NOyfVOi`BoHČǓɈˑ̌ǒoɔ𑣐i邱Ƃ񍐂Ă<a href="#R37"><sup>37)</sup></a>i<a href="#F3">}3</a>jD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@CTRP9ɂ얞֘Aɑ΂hp</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/04/Ouchi-4.e004-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2015/04/Ouchi-4.e004-Fig.3.png&amp;caption=fig3-caption-text]

@}EX̑ړQfɂĂCCTRP9̓^͐V̑}邱Ƃ񍐂Ă<a href="#R38"><sup>38)</sup></a>i<a href="#F3">}3</a>jD|{Ǖ؍זEɂ錟ł́CCTRP9͕؍זȆB}C̋@ɂĂCTRP9AdipoR1AMPLi[[VOicAMP-veCLi[[AVOi`BoH邱Ƃ񍐂Ă<a href="#R38"><sup>38)</sup></a>i<a href="#F3">}3</a>jDAfB|lN`AMPLi[[VOiĕ؍זȆB}C؍זEɂcAMP-veCLi[[AVOi`BoHȂ߁CCTRP9̓AfB|lN`Ƃ͈قȂ@ɂ蕽؍זEɍpƍlCCTRP9ɂcAMP-veCLi[[AVOi`BoH̊Ɋ֗^ê̓肪҂DɁCApoEmbNAEg}EXɑ΂`ECXxN^[pCTRP9𒷊Ԃɂ킽ߏɔ邱ƂɂC򓮖̓dɂ鎉bH̖ʐςщǐTCgJC̔}CۉьǕ؍זE𑝉邱Ƃɂv[N̈艻i邱Ƃ񍐂Ă<a href="#R39"><sup>39)</sup></a>D|{}Nt@[WɂāC_ᖧx|^pN̓Yɂ㏸鉊ǐTCgJC̔́C`ECXxN^[pCTRP9ߏɔ邱ƂɂLӂɗ}邱Ƃ񍐂Ă<a href="#R39"><sup>39)</sup></a>D
@CTRP9̓AfB|lN`ƎêL邾łȂCAfB|lN`ƃIS}[`邱Ƃ񍐂Ă<a href="#R33"><sup>33)</sup></a>DAfB|lN`mbNAEg}EX͑ړQfɂĖ쐶^̃}EXɔאV̑̑傫Ƃ񍐂Ă<a href="#R40"><sup>40)</sup></a>DAfB|lN`mbNAEg}EXCTRP9ߏɔ邱ƂɂV̑}邱Ƃ񍐂ĂCCTRP9̓AfB|lN`̈ꕔ̍p㏞Ă\ꂽ<a href="#R41"><sup>41)</sup></a>D

<h2>3DFGF21ƐSǎ</h2>
@FGF21FGFifibroblast growth factorCۉזEBqjt@~[ɑ镪^pNł<a href="#R42"><sup>42,43)</sup></a>DߔNCFGF21͊̑⍜i؂ɂ킦CbgDɂĂ邱Ƃ񍐂Ă<a href="#R44"><sup>44,45)</sup></a>DFGF21mbNAEg}EX͎bޏkϐǂ̕aԂ悵CCXR<a href="#R46"><sup>46)</sup></a>DCFGF21gXWFjbN}EX͔얞2^Aaɑ΂Rł<a href="#R43"><sup>43)</sup></a>DɁC얞}EXFGF21𓊗^邱Ƃɂ茌l⒆b̌ZxIɉPƂ񍐂Ă<a href="#R43"><sup>43)</sup></a>D[ƂɁCFGF21͎bgDɂăAfB|lN`̔㏸邱ƁCɁCAfB|lN`mbNAEg}EXɂĂFGF21̃CXRɑ΂PpȂȂ邱Ƃ񍐂ĂCFGF21ɂ2^Aaɑ΂Pp̓AfB|lN`̔̏㏸邱Ƃꂽ<a href="#R47"><sup>47,48)</sup></a>D
@ŋ߂ɂȂC}EXɂFGF21ׂ͈ɂSSğ󗬏Qɑ΂یpƂ񍐂Ă<a href="#R49"><sup>49-51)</sup></a>D}EX̐Sğ󗬃f쐻ƂC̑юbgDɂFGF21̔㏸CS؍זEɂFGFe1--klotho-AktVOi`BoHĐS؍זẼA|g[VX}邱Ƃ񍐂Ă<a href="#R51"><sup>51)</sup></a>i<a href="#F4">}4</a>jDM҂ɂŐV̕񍐂ł́CAfmECXxN^[ɂFGF21̔㏸ƁC쐶^̃}EXɂĂ̓AfB|lN`̌Zx㏸C}EX̐S؍[ǃfɂS؂̔Cx̂CS@\ɉPꂽCAfB|lN`mbNAEg}EXł͕͂IɂPȂ<a href="#R52"><sup>52)</sup></a>DCFGF21ɂS؍[ǂ̂̂̐SfO̗}ṕCȂƂꕔ̓AfB|lN`̑̕iĂ邱ƂꂽDCFGF21̓^ɂS؍[ǂ̂̂̉ǐTCgJC̗}ṕCAfB|lN`mbNAEg}EXɂĂ͊Sɏ邱ƂCFGF21ɂS؍[ǂ̂̂̉ǔ̗}p̓AfB|lN`̑̕i邱Ƃꂽi<a href="#F4">}4</a>jD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@FGF21ɂSǎɑ΂hp</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/04/Ouchi-4.e004-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2015/04/Ouchi-4.e004-Fig.4.png&amp;caption=fig4-caption-text]


<h2>4DI`ƐSǎ</h2>
@I`̓CeN`1Ƃ΂ĂCƂƉñKNgtm[XN`Ƃē肳ꂽ<a href="#R53"><sup>53)</sup></a>DI`͌ɕ傳Oʑ̂`邱Ƃ񍐂Ă<a href="#R53"><sup>53)</sup></a>DbgDCƂɓbgDɂčF߂ČZx̓AfB|lN`Ɠlɔ얞ɂĒቺ邱Ƃ񍐂Ă<a href="#R54"><sup>54,55)</sup></a>D
@ߔNCdъƃI`Ƃ̊֘AɂĂ񍐂ĂCI`̌Zx򓮖ǂ̔ƕ̑ւƂ񍐂Ă<a href="#R56"><sup>56,57)</sup></a>D܂C̊҂ł̓I`̌ZxLӂɒႢƂ񍐂Ă<a href="#R58"><sup>58)</sup></a>DāCI`̓AfB|lN`ƓlɁCɂLpȃoCI}[J[ɂȂ邤邱ƂꂽD
@ŋ߁CM҂́C}EX̐Sğ󗬃fɂāCI`̓^ɂ[ǂ͈̔͂Ɍ邱Ƃ񍐂<a href="#R59"><sup>59)</sup></a>Dbg̐VeS؍זEp<em>in vitro</em>ɂ錟ɂCI`AMPLi[[Akt̓Ɨ2̃VOi`BoHĐS؍זẼA|g[VX}邱Ƃ炩ɂꂽ<a href="#R59"><sup>59)</sup></a>DɁCbgDɓٓIȃI`gXWFjbN}EXɑ哮kp{s׃f쐻ƂCS傪ɉP<a href="#R60"><sup>60)</sup></a>D܂CI`̑O^AMPLi[[VOiERKVOi̗}ɂC|{S؍זEtFjtŏ邱Ƃɂ萶S؍זE̔}邱Ƃ񍐂Ă<a href="#R60"><sup>60)</sup></a>i<a href="#F5">}5</a>jDȏCI`͔얞ɂƂȂ鋕SS̎Ö@̐VȕWIɂȂ肤邱ƂꂽD

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@I`ɂSǕیp</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/04/Ouchi-4.e004-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2015/04/Ouchi-4.e004-Fig.5.png&amp;caption=fig5-caption-text]

@xɂẮCI`͐SǕیpƂ񍐂ĂDI`̓Y͓^NOyf̊ČǓɈˑ̌Ǌg𑝋<a href="#R61"><sup>61)</sup></a>i<a href="#F5">}5</a>jD܂C쐶^̃}EXɃI`Sg^ƁCfɂ錌P^NOyfVOii邱Ƃ炩ɂꂽ<a href="#R62"><sup>62)</sup></a>D|{ǓזEpł́CI`̓^AMPLi[[-^NOyfVOi`BoHă}gQɂ錌ǐV𑣐iCǓזẼA|g[VX}邱Ƃ񍐂Ă<a href="#R62"><sup>62)</sup></a>i<a href="#F5">}5</a>jDɁCI`͌ǓזEERK-NF-BVOi`BoH}邱ƂɂCVCAMICAMȂǂ̍זEڒq̔}P̐ڒ}邱Ƃ񍐂Ă<a href="#R63"><sup>63)</sup></a>D܂C}EX̑ړQfɂāCI`̓^AMPLi[[VOiERKVOi}邱ƂɂCV̑B}邱Ƃ񍐂Ă<a href="#R64"><sup>64)</sup></a>i<a href="#F5">}5</a>jDI`͕؍זEɂp38-JNKVOi`BoH}CVCAMICAMȂǂ̍זEڒq̔}邱Ƃ񍐂Ă<a href="#R65"><sup>65)</sup></a>D
@ȏ̂悤ɁCI`͐Sǎɑ΂CAfB|lN`ƗގVOiĖhIȍp𔭊DCAfB|lN`AMPLi[[VOiĐS؍זẼA|g[VX}̂ɑ΂CI`AMPLi[[Akt̓Ɨ2̃VOi`BoHĐS؍זẼA|g[VX}ȂǁCAfB|lN`Ƃ͈قȂ@ɂSǕیp𔭊邱ƂlCI`̎ê̓܂߂ڍׂȃVOi`BoH̉𖾂҂D

<h2></h2>
@ǐAfB|TCgJCƍRǐAfB|TCgJCƂ̃oX̔j]얞֘AɋyڂeɂāC̒mWςD̃r[ɂďЉCAfB|lN`CCTRP9CFGF21CI`ȂǍRǐAfB|TCgJC̔얞ɂƂȂ̒ቺ́CbgD邢͉ȗɂĉǂNӐSǎ̐iWɊ^ĂD䂦CRǐAfB|TCgJC̔㏸邱Ƃ₻̉̃VOi`BoH𑝋邱Ƃ́C얞֘A̎ÂɂVȕWIƂėL]łD܂CCTRP9̓AfB|lN`pOłCêƂăAfB|lN`̎êłAdipoR1L邱Ƃ񍐂Ă邱ƂCCAfB|lN`ƃAfB|lN`pOƂ̑ݍpC܂Cʂ̃VOi`BoH̉͂dvɂȂƍlDق̃AfB|TCgJCƂ̂̑ݍpɊւĂCFGF21͎bgDɂAfB|lN`̔㏸邱Ƃ񍐂ĂD܂CI`̎ê͂܂炩ł͂ȂCAMPLi[[VOiAktVOiȂǃAfB|lN`Ƌʂ̃VOi邱ƂCAfB|lN`Ƃ̑ݍpɂĂȂ錤KvłDC̍RǐAfB|TCgJCCɂ́CVK̃AfB|TCgJC̔C@\Cݍp̌C얞ɂƂȂNꂽ̉ǂƁČʂƂĂ̐Sǎ̔ǁC̐iW̕q@\̉𖾂ɂȂ邱ƂlD

<h2> </h2>
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<li id="R10"><span class='au'>Ohashi, K., Parker, J. L., Ouchi, N. et al.</span>: <span class="ti">Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype.</span> <span class='so'>J. Biol. Chem., 285, 6153-6160 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20028977" target="_blank">PubMed</a>]</span></li>
<li id="R11"><span class='au'>Lovren, F., Pan, Y., Quan, A. et al.</span>: <span class="ti">Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages.</span> <span class='so'>Am. J. Physiol. Heart Circ. Physiol., 299, H656-H663 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20622108" target="_blank">PubMed</a>]</span></li>
<li id="R12"><span class='au'>Mandal, P., Pratt, B. T., Barnes, M. et al.</span>: <span class="ti">Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin.</span> <span class='so'>J. Biol. Chem., 286, 13460-13469 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21357416" target="_blank">PubMed</a>]</span></li>
<li id="R13"><span class='au'>Yamauchi, T., Kamon, J., Ito, Y. et al.</span>: <span class="ti">Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.</span> <span class='so'>Nature, 423, 762-769 (2003)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/12802337" target="_blank">PubMed</a>]</span></li>
<li id="R14"><span class='au'>Takemura, Y., Ouchi, N., Shibata, R. et al.</span>: <span class="ti">Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies.</span> <span class='so'>J. Clin. Invest., 117, 375-386 (2007)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17256056" target="_blank">PubMed</a>]</span></li>
<li id="R15"><span class='au'>Shibata, R., Sato, K., Pimentel, D. R. et al.</span>: <span class="ti">Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms.</span> <span class='so'>Nat. Med., 11, 1096-1103 (2005)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16155579" target="_blank">PubMed</a>]</span></li>
<li id="R16"><span class='au'>Wang, Y., Wang, X., Jasmin, J. F. et al.</span>: <span class="ti">Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection.</span> <span class='so'>Arterioscler. Thromb. Vasc. Biol., 32, 934-942 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22328772" target="_blank">PubMed</a>]</span></li>
<li id="R17"><span class='au'>Denzel, M. S., Scimia, M. C., Zumstein, P. M. et al.</span>: <span class="ti">T-cadherin is critical for adiponectin-mediated cardioprotection in mice.</span> <span class='so'>J. Clin. Invest., 120, 4342-4352 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21041950" target="_blank">PubMed</a>]</span></li>
<li id="R18"><span class='au'>Shibata, R., Ouchi, N., Ito, M. et al.</span>: <span class="ti">Adiponectin-mediated modulation of hypertrophic signals in the heart.</span> <span class='so'>Nat. Med., 10, 1384-1389 (2004)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15558058" target="_blank">PubMed</a>]</span></li>
<li id="R19"><span class='au'>Holland, W. L., Miller, R. A., Wang, Z. V. et al.</span>: <span class="ti">Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.</span> <span class='so'>Nat. Med., 17, 55-63 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21186369" target="_blank">PubMed</a>]</span></li>
<li id="R20"><span class='au'>Tao, L., Gao, E., Jiao, X. et al.</span>: <span class="ti">Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress.</span> <span class='so'>Circulation, 115, 1408-1416 (2007)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17339545" target="_blank">PubMed</a>]</span></li>
<li id="R21"><span class='au'>Kondo, K., Shibata, R., Unno, K. et al.</span>: <span class="ti">Impact of a single intracoronary administration of adiponectin on myocardial ischemia/reperfusion injury in a pig model.</span> <span class='so'>Circ. Cardiovasc. Interv., 3, 166-173 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20332381" target="_blank">PubMed</a>]</span></li>
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<li id="R28"><span class='au'>Ouchi, N., Kobayashi, H., Kihara, S. et al.</span>: <span class="ti">Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells.</span> <span class='so'>J. Biol. Chem., 279, 1304-1309 (2004)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/14557259" target="_blank">PubMed</a>]</span></li>
<li id="R29"><span class='au'>Ohashi, K., Ouchi, N., Sato, K. et al.</span>: <span class="ti">Adiponectin promotes revascularization of ischemic muscle through a cyclooxygenase 2-dependent mechanism.</span> <span class='so'>Mol. Cell. Biol., 29, 3487-3499 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19398582" target="_blank">PubMed</a>]</span></li>
<li id="R30"><span class='au'>Iwashima, Y., Katsuya, T., Ishikawa, K. et al.</span>: <span class="ti">Hypoadiponectinemia is an independent risk factor for hypertension.</span> <span class='so'>Hypertension, 43, 1318-1323 (2004)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15123570" target="_blank">PubMed</a>]</span></li>
<li id="R31"><span class='au'>Ohashi, K., Kihara, S., Ouchi, N. et al.</span>: <span class="ti">Adiponectin replenishment ameliorates obesity-related hypertension.</span> <span class='so'>Hypertension, 47, 1108-1116 (2006)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16651465" target="_blank">PubMed</a>]</span></li>
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</ol>
<div class="au-profile">
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<span class="author">勴 _iKoji Ohashij</span>
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