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<strong>rؕۍOEǓT</strong>
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emailF<a href="mailto:y.araki@iri.titech.ac.jp">rؕۍO</a>C<a href="mailto:yohsumi@iri.titech.ac.jp">ǓT</a>
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̈Zr[, <strong>1</strong>, e005 (2012)@<a href=" http://dx.doi.org/10.7875/leading.author.1.e005">DOI: 10.7875/leading.author.1.e005</a>
Yasuhiro Araki & Yoshinori Ohsumi: <strong>Awakening the hibernation of autophagy research using yeast.</strong>

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<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/09/Ohsumi-1.e005-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2012/09/Ohsumi-1.e005-Fig.4.png&amp;caption=fig4-caption-text]


<strong>3j^pNAtg9</strong>
@Atg9Atg^pN̂ȂŗBCђʗ̈^pNłCCI[gt@S\[̌`ɂĎ̋łƍlĂDŋ߁CזE߂30qAtg9ɑ݂30`60 nm̏Ȇ݂Ƃ炦ꂽ<a href="#R27"><sup>27)</sup></a>Duɂʉ͂Ch{QɉPASɂ͕3Atg9EN[gꂸCȏAtg9E̗݂͂ȂƂCAtg9͎̋ƂĖ̐LɊ֗^CI[gt@S\[`̊jƂďiKɋ@\Ă悤łi<a href="#F5">}5</a>jDAtg9͍ŏIIɃI[gt@S\[̊OɋǍ݂D

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@^pNAtg9</strong>
ђʗ̈^pNłAtg9͍זEɂ30`60 nm̏Eɑ݂Dh{QԂɉĕ3Atg9EPASɃN[gCI[gt@S\[`̊jƂďiKɋ@\ĂDAtg9͍ŏIIɃI[gt@S\[̊OɋǍ݂D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/09/Ohsumi-1.e005-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2012/09/Ohsumi-1.e005-Fig.5.png&amp;caption=fig5-caption-text]


<strong>4jI[gt@W[ɓ2̃rL`ln</strong>
@I[gt@W[ɂĂƂł̂́CAtg^pNɃrL`ln2܂܂邱ƂłƂĂߌł͂ȂDrL`nƂ́CrL`yfiE1jCrL`yfiE2jCrL`K[[iE3j3̍yf̂͂炫ɂCATPɈˑIɁCrL`C[̃OVcƕWI^pÑWc̃ÃA~mƂ̃C\yv`h`nłi<a href="#F6">}6a</a>jD

<a name="F6"></a><div id="fig6-caption-text" style="display: none;"><strong>}6@2̃rL`ln</strong>
iajAtg8Atg12̂2̃rL`lnDrL`iUbj́CE1CE2CE33̍yfɂƋL`DAtg12ɂE1Atg7CE2Atg10CAtg5łDAtg12-Atg5̂Atg16ƕ̂`DAtg8Atg4̃VXeCveA[[ɂC[ɃOVcIoDAtg8ɂE1Atg7CE2Atg3C̓zXt@`WG^m[A~iPEjłDAtg12-Atg5̂ɂAtg8̃zXt@`WG^m[A~iD
ibjAtg8-zXt@`WG^m[A~̂ɂ閌̗ZDAtg8-zXt@`WG^m[A~̂̃zʑ̉ɂ薌ǂȂ킳D̋ÏWE̖CdŵÖŵ݂Zw~t[WUND
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/09/Ohsumi-1.e005-Fig.6.jpg" target="_blank">[Download]</a></div>[hs_figure id=6&amp;image=/wordpress/wp-content/uploads/2012/09/Ohsumi-1.e005-Fig.6.png&amp;caption=fig6-caption-text]

@1998NCAtg12n炩ɂȂ<a href="#R28"><sup>28)</sup></a>D186A~m_cȂAtg12́CEFX^ubgɂAtg12̂̂قɁC40 kDقǑ傫ohF߂ꂽDAtg5EFX^ubgɂ蓯l2{̃ohF߂Cqʂ̃ohAtg12̃EFX^ubgɂ蓾ꂽohƈvDŏIIɁC̍qʂ̃oh́CAtg12C[̃A~m_cAtg5149Ԗڂ̃WcƋL̂ł邱ƂDAtg12C[̃OVčC邢́CAtg5149Ԗڂ̃Wc̕ψقɂČ̂̌`sSƃI[gt@W[sSꂽƂCAtg5WIƂAtg12ɂ郆rL`lnI[gt@W[ɕK{łƍlꂽDŁCE1CE2CE3̎̂ƂȂDoy<em>atg7</em>ψي<em>atg10</em>ψيłAtg12-Atg5̂͏DrL`ln̓ł`IGXeAtg12Atg7̂CсCAtg12Atg10̂ł݂ꂽƁCAtg7rL`yfUba1ƑĂƁCAtg12-Atg7̂<em>ATG10</em>`qɈˑȂAtg12-Atg10̂<em>ATG7</em>`qɈˑƂCAtg7E1CAtg10E2ł邱Ƃi<a href="#F6">}6a</a>jDE3͖ł邪C<em>in vitro</em>ɂč\nɂAtg7Atg10݂̂Atg12-Atg5̂ŐꂽƂCE3͂̌nɂ͕KvȂƍlĂDAtg12nɂ͋tCȂ킿CEAtg12yf݂̑ȂƂCق̃rL`lnƂ͈قȂ_łDAtg12C[OVcł鐬n^ƂĈ`qɃR[hĂD܂CAtg12-Atg5̂Atg16ƑݍpCAtg16Ƃ̌ʑ̂Ƃđ݂D̓ʑ̂̌`PASւ̋Ǎ݂ɕK{łD
@Atg8ЂƂ̃rL`lnɂ邱Ƃ́C2000NɔDAtg8C[Ƀ^O𓱓ƁC͐̂ɂ<em>ATG4</em>`qɈˑIɏꂽDWipCAtg4̓VXeCveA[[łCAtg4ɂAtg8C[̃AMjcOVc̘Io邱Ƃ炩ɂȂ<a href="#R29"><sup>29)</sup></a>Doy<em>atg4</em>ψيɂI[gt@W[sSCC[̃AMjcOVcƂȂAtg8̕ψّ̂ɂꕔ}ꂽƂCAtg8C[̘IoOVcdvł邱ƁC܂CAtg12Ƃ1\ɂ鑊Atg8̓rL`l^pNł邱Ƃ\zꂽDƉudq@ɂAtg8̃I[gt@S\[ւ̋Ǎ݂ώ@ꂽCɈv悤ɁCwIȉ͂ɂĂAtg8͖敪ɑ݂D<em>atg4</em>ψيC[̃OVcAtg8̕ψّ̂łAtg8͖ƑݍpłȂƂCAtg8̐̂ɂWI͖ɋ̂łƍlC͓IɒTꂽĎʁCZx̔Af݂̑̂Ƃł̃EFX^ubgɂ育킸Ȉړx̍2{̃ohF߂ꂽC̎_ł͕WI͕słDNCړx̑傫ȃoh̓zXt@`WG^m[A~̓̃A~mAtg8̃OVcƂA~h`̂ł邱Ƃ炩ɂȂ<a href="#R30"><sup>30)</sup></a>D́C݂܂łɒmĂ郆rL`l^pN̂C^pNł͂ȂWIƂB̗łDAtg8-zXt@`WG^m[A~̂<em>atg7</em>ψّ̂<em>atg3</em>ψّ̂ɂďCAtg8Atg7̂CсCAtg8Atg3̂Ƀ`IGXe݂ꂽƁCAtg3͊VXeCc̋ߖTɂAtg10ƑłƂCAtg7E1CAtg3E2ł邱Ƃ炩ɂȂi<a href="#F6">}6a</a>jDAtg8Atg12͂̂̈قȂE2ɂ炸CʂE1ƂAtg7pƂقȔ@\ĂDAtg12-Atg5̂Atg8̍č\nɓYAtg8̃zXt@`WG^m[A~iD2007Nɂ́CAtg8̃I[gt@S\[`ɂ@\̈[炩ɂȂ<a href="#R31"><sup>31)</sup></a>D<em>in vitro</em>ɂč\nɂāCAtg8̃zXt@`WG^m[A~ɂƂȂCzXt@`WG^m[A~܂ރ|\[ÏŴ`DAtg8-zXt@`WG^m[A~̂̓zʑ̂`ĂƂC̑ʑ̉ɂ薌ǂȂ킹@\̂ƍlꂽDɁC̋ÏWE̖CdŵÖŵ݂Zw~t[WUNĂ邱Ƃ킩i<a href="#F6">}6b</a>jD<em>in vitro</em>ɂă|\[̋ÏWw~t[W̋NȂ邢͒ቺĂAtg8̕ψّ̂𕪗ƂC̕ψّ̂oył͂<em>in vitro</em>ɂ銈ɑւāCI[gt@WbN{fB[łȂCłĂ^I[gt@W[Ɉُ𐶂ƂCAtg8͍זEɂĂI[gt@S\[̌`̍ۂ̖̐LŏIiKɂu̖[̗ZɊ^ĂƍlꂽD

<h2></h2>
@MɂĂ͂܂I[gt@W[̌́C؊ւāCoyɂĂ̕q̂𖾂ꂽDAtg^pN͐ĐiIɍLۑĂC̃zOmbNAEg܂̓mbN_E邱ƂɂCMɂI[gt@W[Č؂ꂽ<a href="#R32"><sup>32)</sup></a>ĎʁC̃̕TCNƂ{IȖ̂قɂɑlȐۂւ̊֗^炩ɂȂC݁CM̃I[gt@W[͋߂ĂDCAtg^pNǂ̂悤ɗL@IɘAgăI[gt@S\[̌`ɂ̂ƂI[gt@W[ɂƂdvȖ́CoyɂĂقƂǉ𖾂ĂȂD
@̑傫ȏǂ̂ЂƂƂāCI[gt@S\[`̑fߒ𖾂邽߂̒ԑ̂ώ@ĂȂƂDoỹI[gt@S\[`K{`q̕ψيłׂ͂āCdqɂώ@ł̓I[gt@S\[̌`݂ꂸCI[gt@S\[`̐is̓rŒ~悤Ȗԑ̂ołĂȂĎŔjɂ́C<em>in vitro</em>ɂI[gt@S\[`̍č\n̍\zĂƂȂł낤DKvƂȂ^pN⎉Ȃǂɂ킽ȍ\zŁC݂܂ł̖ԗIȃXN[jOɂ炸I[gt@S\[`K{`q18瑝ĂȂƂCT^IAtg^pNׂ͂ĒPĂƍlDmAtg^pNƂ̊֘A^pNCсC邱ƂŁC񂪂ȒPɃI[gt@S\[l̎dȂ鏬Ȅoώ@邩ȂDɂ́CI[gt@S\[̎g̉𖾂K{ł낤D܂Ŗ̗ZɂẮCSNAREpZCtE̗Z<a href="#R33"><sup>33)</sup></a>CGh\[̗ZȂ<a href="#R34"><sup>34)</sup></a>C<em>in vitro</em>Sč\n̐ႪUDI[gt@S\[͓dłCɁČ`ߒ͖̐LCό`CZȂ邽߁C̕G͂Ƃ͔rɂȂȂDC<em>in vitro</em>ɂč\n\z΁C瓾鉶b͌v肵Ȃ̂ɂȂł낤D

<h2> </h2>
<ol>
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</ol>

<h2>Ql}</h2>
<ol>
<span class="ti">Special Issue on Autophagy.</span> <span class='so'>FEBS Lett., 584, 1279-1436 (2010)</span>
</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">r ۍOiYasuhiro Arakij</span>
F2001N ww@wnȔmے CC CpPaterson Institute for Cancer ResearchChCcHeidelbergwZMBHCHƑwi@\ ioāC2011N蓌HƑwteBA@\ CD
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<strong> ǓTiYoshinori Ohsumij</strong>
HƑwteBA@\ CD
URLF<a href="http://www.ohsumilab.aro.iri.titech.ac.jp/" target="_blank">http://www.ohsumilab.aro.iri.titech.ac.jp/</a>
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? 2012 rؕۍOEǓT Licensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
