זȆ\K肷镪q@\

<strong>OH mj</strong>
iwEĐȊwZ^[ \זEvWFNgj
emailF<a href="mailto:niwa@cdb.riken.jp">OHmj</a>
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̈Zr[, <strong>1</strong>, e008 (2012)@<a href="http://dx.doi.org/10.7875/leading.author.1.e008">DOI: 10.7875/leading.author.1.e008</a>
Hitoshi Niwa: <strong>Molecular mechanism governing pluripotency of stem cells.</strong>

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<h2>v </h2>
@}EX̒O󂩂ꂽ}EXESזÉCTCgJĈЂƂLIFɈˑIɑ\ێĂDLIFVOi͕̓]ʈq̐\Ɋ֘A]ʈqlbg[Nɓ͂ĂDƂ͕ɁCt^pNłWnt\̈ێɊ^邪CWntVOiTcf3ɂ<em>Esrrb</em>`q̔}ƂЂƂ̓_ɂđ\Ɋ֘A]ʈqlbg[Nɓ͂ĂDC}EX̒󂩂ꂽ}EXEpiSCiGsuXgזEj̓AN`rFgf2Ɉˑđ\ێĂ邪C̓]ʈqlbg[Nւ̓͗l͖炩łȂDCEpiSCłLIFVOiWntVOiւ̓͂ɂ]ʈq̔͗}ĂCꂪقȂ鑽\זE̐K肵Ă\Dł́CזËقȂ鑽\̏ԂiC[u^уvC^Ƃċʂ̂ʓIłCqgESזE͂̕ނł̓vC^ɑDC܂Œ񏥂Ă2̏Ԃ̍ق̂Ľ`\͐ΓIȂ̂Ƃ͂C}EXEpiSCEJhwߐɔ邾ŁCՖE̒̓Ľ`Ɋ^DCiC[u^уvC^̏Ԃɂĕ\^ƃVOi̓́CсC]ʈqlbg[N̏Ԃ𒍈Ӑ[Ή邱ƂɂCiC[u^̏ԂK肷̉𖾂҂D

<h2>͂߂</h2>
@זÉCȈȊO̎ނ̍זEɕ\́i\jƁCזEւĎȂƓ̕\זE𐶂ݏo\́iȕ\jƂ킹זEƂĒ`D̂C\Ƃđ\זE𑽔\זEƂԁD\́CƂՓIɂ͎OtׂĂɕł\͂ƂċK肳D󐫂זEiembryonal carcinoma cellCECזEj͗jIɂ͂߂đ̊OŔ|{ꂽ\זEłDECזE͊`iteratocarcinomajƂ΂Ot݂̐ᇂɗRC}EXɈڐA邱Ƃɂӂъ``Ƃ瑽\ƂmFꂽDɁCIɌ`ꕔ̊`ɗRECזEł́Cւ̈ڐAɂ萳ȔߒɊ^ĎOtɕCL}EX̌`\ł邱ƂmFꂽ<a href="#R1"><sup>1)</sup></a>DāCECזE̒mɂƂÂC1981NC}EXՖE̓זE򂩂󐫊זEiembryonic stem cellCESזEjꂽ<a href="#R2"><sup>2,3)</sup></a>DESזEՖEւ̈ڐAɂ荂ɃL}EX`CŐBזEnɂ^DɂCV[ɂĔ|{ESזEɂ킦`q̌̂ւƓ`B铹񂩂C̈`q@\rCmbNAEg}EX̍쐻\ɂȂD̋Zp̔шwւ̌т͑傫CJ҂2007Ñm[xww܂܂ĂDŁCESזE͑\K肷镪q@\̉𖾂̊ՂƂȂC瓾ꂽmɂƂÂC2006NC<em>Oct3/4</em>`qC<em>Sox2</em>`qC<em>Klf4</em>`qC<em>Myc</em>`q4̈`q𓱓邱Ƃő̍זE邱ƂɂCU^\זEiinduced pluripotent stem cellCiPSזEj쐻ꂽ<a href="#R4"><sup>4)</sup></a>Ď𐬂RL킪2012Ñm[xww܂܂Ƃ͋LɐVD̃r[ł́C猤̊ՂƂȂ\זEȕƕ𐋍s邽߂̕q@\ɂčŋ߂̒mTD

<h2>1D}EXESזȆ\K肷镪q@\</h2>
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<strong>1D1DLIFVOi`BoHɂ鑽\ێ̋@\</strong>
@}EXESזÉC1981N̍ŏ̎̕񍐂ɂẮCʏ̌ܗL|npC}EXَe̎悵ۉזȄŏdw|{ĂD1988NCLIFileukemia inhibitory factorCa}qj}EXESזE̕}\ێt^pNƂčp邱Ƃ񍐂ꂽ<a href="#R5"><sup>5)</sup></a>DLIF͂ȑOM1aזE̕U^pNƂē肳ĂC^[CL6t@~[ɑTCgJCłC}EXESזEɑ΂Ă͂Ƃ͋tɕ}̌ʂC|nւLIF̓YɂCۉזEƂ̏dw|{ȂɃ[`̏Ń}EXESזȆ\ێ邱ƂłDLIFGp130LIFẽȂLIFêɌCזEɂ3̃VOi`BoH쓮i<a href="#F1">}1</a>jD̂CJak-Stat3oH@\Iɏdvł邱ƂC̋@\̑rɂLIF̑݉Ń}EXESזE̕U邱<a href="#R6"><sup>6)</sup></a>CсC̐lדIȊɂLIF̔񑶍݉Ŏȕێ邱<a href="#R7"><sup>7)</sup></a> ɂؖꂽDCLIFPI3Li[[-AktoH邪CAkt̐lדIȊɂĂLIF̔񑶍݉Ŏȕ͈ێ邱Ƃ񍐂Ă<a href="#R8"><sup>8)</sup></a>D

<a name="F1"></a><div id="fig1-caption-text" style="display: none;">}1@}EXESזEɂLIFVOi̓</strong>
LIFVOiJak-StatoHCPI3Li[[-AktoHCGrb2-MAPLi[[oH3̃VOi`B@\CقȂ͂]ʈqlbg[Nɂ<a href="#R11"><sup>11)</sup></a>D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/12/Niwa-1.e008-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2012/12/Niwa-1.e008-Fig.1.png&amp;caption=fig1-caption-text]

@ł́C̃VOi`BoH͂ǂ̂悤Ȉ`q̔邱Ƃő\̈ێɊ^Ă̂낤H@̓̂߁C}EXESזEɂĖԂɂēٓIɔ]ʈqāCLIF̔񑶍݉Ŏȕێ邩ǂꂽĎʁC2003NɃzI{bNX]ʈqNanog<a href="#R9"><sup>9,10)</sup></a>C2009NɂKruppelt@~[ɑWNtBK[]ʈqKlf4T{bNX]ʈqTbx3<a href="#R11"><sup>11)</sup></a>Ĉ悤Ȕ\͂ƕ񍐂ꂽDāĈKlf4Jak-Stat3oHɂāCTbx3NanogPI3Li[[-AktoHɂāC̔̊邱Ƃꂽi<a href="#F1">}1</a>jD
@ŁC1990NCECזEp͂C2̃zI{bNX֘ADNÄ]ʈqOct3/4ԂɂēٓIɔĂƕ񍐂ꂽ<a href="#R12"><sup>12-14)</sup></a>D2000Nɂ́COct3/4̔ʂɈێ邱Ƃ}EXESזEɂ鑽\̈ێɕK{łC̔ʂ̑LIF̏ƓlɕUČ͉h{Otւ̕U邱Ƃ񍐂ꂽ<a href="#R15"><sup>15)</sup></a>DOct3/4Sryt@~[ɑHMG{bNX]ʈqSox2ƕ̂`WI`q̓]ʂ<a href="#R16"><sup>16)</sup></a>DSox2܂}EXESזEɂ鑽\̈ێɕK{łC̋@\͉̌h{Otւ̕U<a href="#R17"><sup>17)</sup></a>DOct3/4̋@\}h{Otւٓ̕IɗU@\ƂāCOct3/4͉h{Otւ̕w߂zI{bNX]ʈqCdx2Ƒݗ}H`COct3/4̔Cdx2̔Uĉh{Otւ̕ÛƍlĂ<a href="#R18"><sup>18)</sup></a>D܂CSox2Oct3/4Ƒ݊H`CSox2̔Oct3/4̔ւāCʓIɉh{Otւ̕UƍlĂD
@ł́CLIF̃VOi`BoH͂ǂ̂悤Oct3/4邢Sox2ɘAĂ̂낤H@Oct3/4̔𐧌䂷]ʈqƂāCOct3/4CSox2CNr5a2CNanogCEsrrbȂǂ񍐂ĂDāCNanog̘͂A^pNƂďdvƍl邪CŁCNanogזE͕sȂ\ێł̂ŁCꂾł͐łȂ<a href="#R19"><sup>19)</sup></a>DKlf4Oct3/4Sox2ƋĕWI`q̓]ʊɂ͂炭Ƃ񍐂ĂC@\IȘAɏdvƍl<a href="#R20"><sup>20)</sup></a>D܂COct3/4ɂ蒼ڂɐ䂳WI`q̌Ƃ<em>Klf4</em>`qC<em>Tbx3</em>`qC<em>Nanog</em>`qC<em>Nr5a2</em>`qC<em>Esrrb</em>`qׂĂĂ邱ƂCɃR[h]ʈq̓lbg[N`Ȉ艻sĂƍl邪C̍\̏ڍׂ͉𖾂ĂȂD
@Myc܂CLIFVOi`BoHɊ֗^]ʈqƍlĂDψٌ^Myc̋ɂLIF̔񑶍݉Ŏȕێ邱Ƃ񍐂Ă<a href="#R21"><sup>21)</sup></a>DCMycPƂŌ}EXESזE͐Ɏȕ邪CMycMycnƂ̓d}EXESזE̊Otւƕ邱ƂCMyct@~[̋@\Iȏdꂽ<a href="#R22"><sup>22)</sup></a>DCMyc̓ʑ̌`̃p[gi[łMax}EXESזE͒ʏ̌ܗL|nł͈ێłȂCGSK3jQ܂MAPKjQ܂܂ޖ|niqjł͈ێłƂCMyct@~[̋@\̓}EXESזEɂ鑽\̈ێɖɕKvł͂ȂƂ<a href="#R23"><sup>23)</sup></a>D

<strong>1D2DFGFVOi`BoHɂ镪Ű@\</strong>
@LIFɂ芈3̍זEVOi`BoHƂMAPLi[[oHi<a href="#F1">}1</a>jĎoH́C}EXESזÊFGF4ɂhFGFê̍זEVOi`BoHłDMAPLi[[oH͑\̈ێɝhRĕUɂ͂炫CFgf4邢Erk2̌ɂ肱̌oH̊jQƁC}EXESזE̎ȕ͈艻Iȕ}<a href="#R24"><sup>24)</sup></a>D܂CMAPLi[[NanogTbx3̊jւ̈ڍsɗ}Iɂ͂炭Ƃ񍐂Ă<a href="#R11"><sup>11,25)</sup></a>DC܂łMAPLi[[oHɂ@\IȕWI^pN͕񍐂ĂȂD

<strong>1D3DWntVOi`BoHɂ鑽\ێ̋@\</strong>
@Wnt͔ߒ̂܂܂ȏʂł͂炭t^pNłDWntVOi͌ÓTIoHɂĂFrizzledLrp5邢Lrp6ƂȂêւGSK3̗}ɂ͂炭i<a href="#F2">}2</a>jDGSK3̓Jej_̕𘴐îŁCWntVOi̎hɂGSK3̗}̓Jej艻D艻~ςJej͊jւƈڍsCTcft@~[ɑ]ʈqƋĕWI`q̔𐧌䂷D2004NC}EXESזEɑ΂Wnt3ajQ܂邢GSK3jQ܂̓Y͑\̈ێɊ^邱Ƃꂽ<a href="#R26"><sup>26)</sup></a>D2008Nɂ́CGSK3jQ܂MAPLi[[jQ܂𓯎ɓY邱ƂɂC|nɂă}EXESזȆ\ێł邱Ƃ񍐂ꂽ<a href="#R27"><sup>27)</sup></a>DGSK3jQ܂MAPLi[[jQ܂gݍ킹|ni2i|njLIFȂɑ\ێł邪CLIF킦Ƒ\ێ̌ʂ邱ƂC̍זEVOi͋Iɂ͂炫悤łD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@}EXESזEɂWntVOi̓</strong>
WntVOiGSK3̊}CJej̈艻Ɗjւ̈ڍsւē]ʗ}qTcf3̋@\}C̕WIł<em>Esrrb</em>`q̓]ʊЂNƂɂ葽\̈ێɊ^Ă<a href="#R29"><sup>29)</sup></a>D̂ƂCTcf1ɂ]ʊU邪C̑\̈ێւ̊^͊mFĂȂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/12/Niwa-1.e008-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2012/12/Niwa-1.e008-Fig.2.png&amp;caption=fig2-caption-text]

@ł́CWntVOi`BoH͂ǂ̂悤Ȉ`q̔𐧌䂷邱Ƃő\̈ێɊ^Ă̂낤H@Tcft@~[ɑ]ʈq̂ЂƂTcf3̓}EXESזEɂĂ̋@\Ƒ\̈ێ艻邱ƂC}EXESזEɂWntVOi`BoH̋@\Iȍ\^pNł邱ƂꂽDŁCTcf3͂ɓ]ʗ}qƂĂ͂炭ƁCāC̋@\WntVOi̎hɂjɒ~ςJejƂ̌ɂ}邱Ƃ񍐂ꂽ<a href="#R28"><sup>28)</sup></a>DȂ킿CWnt3ajQ܂邢GSK3jQ܂̓^̓Jej̊ւTcf3ɂWI`q̓]ʗ}邱ƂɂC\̈ێɊ^Ă̂łDCWntVOi̓}EXESזEɂĂJejTcf1Ƃ̂̌̕`<em>Axin2</em>`qȂǂ̕WI`q̓]ʊNC̑\̈ێւ̊^͂܂ł̂Ƃ댟؂ĂȂDŋ߁CTcf3ɂ]ʗ}WI`qƂ<em>Esrrb</em>`q肳ꂽDEsrrb̐lדIȔ̈ێGSK3jQ܂̌ʂւłCEsrrb}EXESזEGSK3jQ܂ւ̉rDŁCEsrrb̐lדIȔ̈ێNanogKlf4CTbx3ƓlLIF̌ʂւłCEsrrb}EXESזELIF̑݉ł͑\ێ邱ƂłDCEsrrb̋@\GSK3-Tcf3oH̕WIƂĂ͕KvLIFVOi`BoH̊ɂ㏞\łCLIFVOiWntVOi̓]ʈqlbg[Nւ͕̓͂\ŁCCƂ邱Ƃ\ɂȂ<a href="#R29"><sup>29)</sup></a>i<a href="#F2">}2</a>jD

<strong>1D4D\ƃGsWFleBNX</strong>
@܂ŁCVOi̓͂Ƃ̊֘AɂāCɓ]ʈqɂ`q̔ɂƂÂiWFleBbNȁj@\ɂďqׂDōŋ߁CGsWFleBbNȐ@\\̈ێɊ^Ă邱Ƃ񍐂ĂD
@ATPˑIN}`č\̂̂ЂƂłNuRDinucleosome remodelling and histone deacetylaseĵ́C̑\̈ێւ̊^@\Iɏؖꂽŏ̃GsWFleBbNqłDNuRD̂̍\^pN̂ЂƂłMbd3}EXESזE͕ɑ΂RCLIF̔񑶍݉łȕ𑱂<a href="#R30"><sup>30)</sup></a>DNuRD̂͂ɓ]ʂ}@\ƂmĂCŋ߁C}EXESזEɂNuRD̂Klf4CKlf5CTbx3CRex1Ȃǂ̔}ĂČ͂̓]ʈq̔𑝉邱Ƃɂ蕪ɑ΂RU邱Ƃꂽ<a href="#R31"><sup>31)</sup></a>DCqXgE`yfLSD1NuRD̂̍\^pNł邪C̋@\͑\̈ێɂ͊֗^CÛ̂̈`q̔Ɋ^Ă悤ł<a href="#R32"><sup>32)</sup></a>D
@BAF̂ATPˑIN}`č\̂̂ЂƂł邪Cɓ]ʊɊ^_NuRD̂Ƃ͈قȂD}EXESזEɂESזEɓٓIȍ\^pN܂esBAF݂̂COct3/4NanogƌĂ]ʈqɂWI`q̓]ʊɊ^邱ƂmĂ<a href="#R33"><sup>33)</sup></a>D܂CQmChȉ͂łesBAF̂Stat3ƂƂǍ݂C̕WI`q̔ւ̊^Ă<a href="#R34"><sup>34,35)</sup></a>D
@}EXESזEł͈`qR[ḧ̃N}`SʂɃ[N}`ԂɂCqXǧpxɋNĂ邱ƂmĂ<a href="#R36"><sup>36)</sup></a>D̂悤ȏԂ̈ێɂ͓]ʊɂqXgCp^[̐ϋɓIȌ`֗^ĂƍlDqXgAZ`͓]ʊɂqXgC̑\ł邪C̏C𓱓qXgAZ`gXtF[[ihistone acetyltransferaseFHATĵЂƂTip60́CmbN_Eɂ@\IȃXN[jO瑽\̈ێւ̊^Ă<a href="#R37"><sup>37)</sup></a>D܂ŋ߁Cʂ̃qXgAZ`gXtF[[łMOF/Myst1/Kat8}EXESזEɂ鎩ȕ̈ێɕK{ł邱Ƃ񍐂ꂽ<a href="#R38"><sup>38)</sup></a>DqXgH34Ԗڂ̃Wc̃`iH3K4mej]ʊɂqXgĈЂƂłCTrithoraxO[vitrxGĵ̓Ɋ֗^ĂD}EXESזEɂTrithoraxO[v̂̍\^pN̂ЂƂWdr5́CQmɂOct3/4ƋǍ݂\̈ێɊ^ĂƍlĂ<a href="#R39"><sup>39)</sup></a>D
@Ƃ͑ΏƓIɁC̃GsWFleBbNȐ@\̓weN}```q}ɂ͂炭C}EXESזȆ\̈ێɂ͕KvȂ<a href="#R40"><sup>40)</sup></a>DPolycomb}2iPRC2j̓qXgH327Ԗڂ̃Wc̃`iH3K27me3j𓱓ē]ʂ}邪C}EXESזEɂĂ̍\^pNłEedCSuz12CEzh2H3K27me3قڏłĂ\͈ێD܂CH3K4me3H3K27me3݂̍񉿂̃hCibivalent domainj̓}EXESזEɂĎȕƕ̐ɂGsWFleBbNȏԂƂĒڂ߂Cŋ߂̕񍐂ł́CGSK3jQ܂MAPLi[[jQ܂킦2i|nŔ|{ꂽ}EXESזEɂẮCQmɂH3K4me3H3K27me3݂̍hCĂɂ炸C̑\̏Ԃ͂ނ똴iĂ邱ƁCāC̕ỦߒłH3K4me3H3K27me3݂̍hC̏o͖mł͂ȂƂꂽ<a href="#R41"><sup>41)</sup></a>DāCH3K27me3̓ɂH3K4me3ƍ݂hČ`ɂ͋@\IȈӋ`݂͑Ȃƍlق悢ƎvD

<h2>2D}EXEpiSC̑\K肷镪q@\</h2>
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<strong>2D1D}EXEpiSCƂ́H</strong>
@}EXESזE͎q{ɒOՖEꂽ\זEł邪C2007NC̐i񂾒̌󂩂\זEꂽ<a href="#R42"><sup>42,43)</sup></a>D̍זE̓GsuXgזEiepiblast stem cellCEpiSCjƖC}EXESזEƂ͂܂܂ȓ_ňႢi<a href="#F4">\1</a>jD}EXEpiSC̑BLIFɂ͈ˑC}EXESזEɂLIFVOi̓͂ɂ]ʈqłKlf4Tbx3ĂȂDCNanog͔Ă邪C̔EpiSC̎ȕɕKvȉt^pNłAN`r̃VOiɂ萧䂳Ă邱ƂĂDŋ߁CNanogEpiSCꂽ̂ŁC}EXESזEƓlɁCNanog̋@\EpiSCɂ鑽\̈ێɂK{ł͂ȂƂ<a href="#R44"><sup>44)</sup></a>D

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>\1</strong>@<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/12/Niwa-1.e008-Table-1.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2012/12/Niwa-1.e008-Table-1.png&amp;caption=fig4-caption-text]

@}EXESזEEpiSC̔|{ɂĔ|{𑱂ƁC̈ꕔEpiSCl̑\זEւƈڍs邱Ƃ񍐂ĂDtɁCEpiSCSK3jQ܂MAPLi[[jQ܂킦2i|nł͕Ă܂CLIFƌ܂ޔ|nł킸ESזEl̑\זEւ̈ڍsF߂ɂȂDĈƂC}EXESזEɂēٓIɔĂ]ʈqKlf2CKlf4CNanogCTbx3CEsrrbCNr5a1CNr5a2̂ǂꂩЂƂߏ蔭邩C邢́CLIFVOiIɊƁC̍זEESזEl̑\זEւƁgvO~Oh<a href="#R45"><sup>45,46)</sup></a>DāCESזEEpiSCւ̈ڍs͔ߒ̏̕ωłĊ{Iɂ͕stIłC̋tsɂ͕זȄꍇƓlɈ`qKvƂD
@ł́CEpiSC͔ߒɂĂǂ̎̑\זȄԂɋ߂̂낤H@}EXESזE̎nBזE̕Ȕ̌ɂC}EXESזE番`ꂽ̑\זEɑԂ͎nBזEUł̂ɑ΂CEpiSC͓l̔|{ł͗UłȂƂ񍐂ꂽ<a href="#R47"><sup>47)</sup></a>DɁC̍זEюnBזE`܂̒i5.5jɂ鑽\זË`qvt@C̔rCEpiSC͂̎̑\זEƂ͈قȂĂ邱ƂꂽĎʂCEpiSC͐BזÊC6ȍ~̎̑\זEɋ߂ƐD

<strong>2D2DEpiSC̓K肷镪q@\</strong>
@ł́CESזEEpiSCƂ̈Ⴂ͂ǂ̂悤ȕq@\ɂK肳Ă̂낤H@ɏqׂEpiSCvO~O銈]ʈq́C}EXESזEɂĂ͂LIFVOi`BoHɊ֗^ĂCꂼ̋@\ESזȆ\̈ێɂĕK{ł͂ȂƂ_ŋʂĂDāC}EXESזEɓIȑ\LIFVOiւ̉ɈˑĂƍlDC}EXESזEƔrEpiSCɂċ`qCEpiSCɓIȑ\K肷@\Iȃ^pN͂܂œ肳ĂȂD
@EpiSC̓GsWFleBbNȐ̓_ł}EXESזEƂ͑傫قȂĂDł͒̒ɂăGsWFleBbNȐɂ2{XF̂̈̕sN邪C̃}EXESזE͒O2{XF̂ƂɊȏԂێĂ̂ɑ΂CEpiSCł1{XF̂ɕsNĂD܂C̉ߒŐ䂳`q̃qXgCԂɂ炩ȈႢ񍐂ĂDɁC<em>Dnmt3a</em>`q<em>Dnmt3l</em>`qƂDNA`Ɋ֗^`q̔EpiSCɂčƂώ@ĂDĈ悤ȈႢǂ̂悤ɂEpiSC̕\^ɋ@\IɊ֗^Ă͖̂炩łȂD

<strong>2D3DEpiSC̃Lւ̊^\</strong>
@ESזEEpiSCƂʂ\^ƂāCՖEɒꂽƂ̃Lւ̊^\D2007N̕񍐂ł́CEpiSCՖEɒĂقƂǂ͓זEƗZC킸ȃL󂪉ꂽɂȂƂĂ<a href="#R42"><sup>42,43)</sup></a>DCEpiSC͒ɗR鑽\זEłCOՖEւ̈ڐÄُ͈ڐAł邩CꂪLɊ^łȂRƂlD܂CEpiSĈƂƂȂ钅̑\זE܂C󔭐̉ߒɂĎOtւ̕\ƂCEpiSCΓIȈӖŃLւ̊^\rĂƂ͍lɂDEpiSC̃Lւ̊^\𐳓ɕ]邽߂ɂ͒ւ̓̈ڐAsƂzICɂ͋ZpIɍD
@ōŋ߁CM҂́CEJhwߐɋEpiSCՖEɒC̃Lւ̊^\<a href="#R48"><sup>48)</sup></a>i<a href="#F3">}3</a>jDEJhwŔCEJhw̓}EXESזEɂčזEԐڒǂ傽ڒqł邱ƁCāCߋ̕񍐂łEpiSCł͂̔ቺĂƂĂƂɂDEJhw2Ԃɂ킽蔭EpiSCɂẮC}EXESזEɓٓIȈ`q̔͗UꂸC܂CXF̂̍ĊF߂ȂƂC}EXESזEɓٓIȓ]ʈqƂ̂悤ȃvO~O͗UĂȂƍlꂽDC̍זEՖE1ƁC5ǍDȃL`DāCEpiSCLւ̊^\rĂ悤ɂ݂̂͂̐ΓIȔ\͂̌̂ł͂ȂCC}EXESזEɓٓIȓ]ʈq̋@\̓Lւ̊^\K肷̂ł͂ȂƂD܂C̕@ō쐻ꂽL}EXłEpiSCɗRזE̐BזEnւ̊^͊ώ@łȂD́Cɏqׂ悤ɁCEpiSCBזEn̂̂́̕C̑\זȄԂɋ߂Ƃ𔽉fĂ̂ȂD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@EJhw̔ɂ}EXEpiSC̃Lւ̊^</strong>
iajEJhw𔭌UĂ2ڂ̃}EXEpiSCCROCKjQ܂̑݉ŒPזEɉ𗣂ՖEɒD
ibjEpiSCEJhw̔ɈˑIȃLւ̊^<a href="#R48"><sup>48)</sup></a>D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/12/Niwa-1.e008-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2012/12/Niwa-1.e008-Fig.3.png&amp;caption=fig3-caption-text]


<h2>3D\זËʓIȕ</h2>
@1981Ñ}EXESזE̎̕񍐂̂̂C܂܂ȓ킩ESזE݂̎ꂽCLւ̊^\̏ؖ܂ސ̕񍐂͊FłD1995NCՖẼTESזE̎񍐂ꂽC̔|{̓}EX̂̂Ƃ͈قȂCLIF̑ɃAN`rFgf2܂ނ̂ł<a href="#R49"><sup>49)</sup></a>D1998Nɂ́C|{ŃqgESזE̎񍐂<a href="#R50"><sup>50)</sup></a>Ĉ̂Cق̓킩łՖEESזE̎łȂꂽD
@Ĉ悤ȃ}EXƂȊO̓ESזE̔|{ɂˑ̈Ⴂ́C}EXɂĎٓILIFVOi\̈ێɂ͂炭߂łƉ߂ꂽDCɏqׂ}EXɂEpiSC̎́Ĉ悤ȏ󋵂ςD}EXEpiSĆC}EXȊO̓ESזEƓCAN`rFgf2ɈˑIɑ\ێĂ݂̂Ȃ炸CȊO̐ɂĂC}EXESזE肱ESזEɎĂD́C}EXESזEƂȊO̓ESזËႢ́CɈˑIȈႢƂC瑽\זEV[ɂĂƂǂ܂iK̈Ⴂł邱ƂĂD
@C}EXEpiSCƂق̓ESזEiƂ΁CqgESזEjƂɂ͌IȈႢDO҂ɗR̂ɑ΂C҂͒OՖEɗRCƂ_łDŁCqgESזE}EXEpiSCɎĂȂ΁CqgESזẺ͎ߒɂĒɑ܂Ŕ\זȄWcɗRCƂƂȂ̂낤H@ŋ߁C̓_鋻[ʂ񍐂ꂽD}EXՖE̓זELIFܗL|nŔ|{ESזEł邪CAN`rFgf2ܗL|nŔ|{EpiSCł̂<a href="#R51"><sup>51)</sup></a>D́CɏqׂqgESזE̎Ɋւ鉼x̂łD
@qgESזE}EXESזEƑł͂ȂCނC}EXEpiSCƑłȂCgESזEhƂP͒Pɂ̍זEȌɗRƂȏŁCזȄԂ̑\킹ĂȂƂɂȂD2009NC}EXESזE^̑\̏ԂiC[u^\ina?ve pluripotencyjC}EXEpiSC^̑\̏ԂvC^\iprimed pluripotencyjƂ镪ނ񏥂ꂽ<a href="#R52"><sup>52)</sup></a>Dɂ΁CqgESזE̓vC^\זEɕނ邱ƂɂȂD݁C̕ނ͑\זE̐ɂ镪ނƂĕyD

<h2></h2>
@ł́C̑\זEꂽזEiC[u^ɂȂ邩vC^ɂȂ邩͂ǂ̂悤Ɍ肳̂낤H@ɏqׂʂ炩Ȃ悤ɁCɂ2̃p[^[݂DЂƂ͗RזE̔iKŁCiC[u^\זEvC^\זE邱Ƃ͂ĂC̋t͂肦ȂDЂƂ͔|{ŁCiC[u^̏Ԃێł|{݂ȂCiC[u^\זEɗRĂƂĂ|{ꂽזE̓iC[u^ł͂肦ȂD_ŁCiC[u^̏Ԃێł|{̓}EXуbgƂނɂĂmĂȂDGSK3jQ܂MAPLi[[jQ܂킦2i|nɂ|{CވȊOł̓iC[u^\̈ێɂ͏\ł͂Ȃ悤łDɂ́Cɂ閾炩ȈႢ݂DȂCiC[u^\זEɂ̓vC^\זEɎpIɂ܂DƂ΁C`qǧ̓iC[u^\זÊق͂邩ɍCvC^\זEɂ`q^[QeBO͒ʏ̕@ł͍łD܂C2i|nɂ|{ɂ݂悤CiC[u^\זÊقψȐňێ邱Ƃ\łiǗ̓_ŗLłDC}EXESזEɂiC[u^\̈ێ@\VOi̓͂Ƃ̊֘AɂĖ炩ɂCɂ̃vC^\ւ̈ڍs̉ߒɂῶ邱ƂɂC̕ǂCՓIȃiC[u^\זE̔|{̊m҂D

<h2> </h2>
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</ol>
<div class="au-profile">
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<span class="author">OH mjiHitoshi Niwaj</span>
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