zXt@`WCmVg[4-_ɂזE@\̐

<strong>  j</strong>
iVww@㎕wn _owj
emailF<a href="mailto:nakatsu@med.niigata-u.ac.jp"> j</a>
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̈Zr[, <strong>5</strong>, e008 (2016)@<a href="http://dx.doi.org/10.7875/leading.author.5.e008">DOI: 10.7875/leading.author.5.e008</a>
Fubito Nakatsu: <strong>Role of phosphatidylinositol 4-phosphate in cellular function.</strong>

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<h2>v </h2>
@CmVg[̖͐\郊̈łCCmVg[_邢͒E_邱Ƃɂ7ނ̈قȂCmVg[YDCmVg[͍זEIKlɓƎِ̓ɂċǍ݂CVOi`BCזEiCugtBbNȂǂ܂܂ȍזE@\ɖڂɊ֗^DȂłCzXt@`WCmVg[4-_͍זESŴɖLxɑ݂CX̃GtFN^[^pNN[g邱Ƃɂ薌_Ci~NX𐧌䂵CzXt@`WCmVg[4,5-rX_̑ÔƂċ@\肷DɋߔNCzXt@`WCmVg[4-_͏ÊƍזEƂ̐ڐGʂ邢͏ÊƃSŴƂ̐ڐGʂAɂĕK{̖SƂ炩ɂꂽD̃r[ɂẮCCmVg[̂Ȃł܂@\̂킩ĂȂzXt@`WCmVg[4-_ɒڂC̍זE@\ɂāCƂɖڐGʂA̕q̂Ƃ̋@\ɂӂCM҂ɂŋ߂̌̐ʂ܂ĉD

<h2>͂߂</h2>
@CmVg[̖͐\郊̈łCeƂăCmVg[DזEɂĐ̖ɂ郊̑ʂɂ߂銄͖1Ɣʂł邪C܂܂ȍזE@\ǂdvȎłDCmVg[̓ƂāCזȆɕ\oCmVg[3ʁC4ʁC5ʂɉtIɃ_邢͒E_NC̑gɂ7ނ̈قȂCmVg[Y邱Ƃ<a href="#R1"><sup>1)</sup></a>D̃CmVg[͍זEIKlȂǂ̖̐ɂċψɕẑł͂ȂC̖̐ɔZkĕz<a href="#R2"><sup>2)</sup></a>DƂ΁CzXt@`WCmVg[4,5-rX_͍זEɁCzXt@`WCmVg[4-_͍זEуSŴɁCzXt@`WCmVg[3-_zXt@`WCmVg[3,5-rX_̓Gh\[у\\[ɁCꂼꑽ݂i<a href="#F1">}1</a>jD́Ĉ̂̃CmVg[̍邢͑ӂ𐧌䂷Li[[уzXt@^[[̖̐ɈقȂِɂċǍ݂邱ƂɋN<a href="#R1"><sup>1,3)</sup></a>D

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@CmVg[̕q킨т̍זEɂǍ</strong>
CmVg[3ʁC4ʁC5ʂ_邢͒E_邱Ƃɂ7ނ̈قȂCmVg[YD̃CmVg[́CזEɂčזEIKlɓƎِ̓Ǎ݂D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/09/Nakatsu-5.e008-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2016/09/Nakatsu-5.e008-Fig.1.png&amp;caption=fig1-caption-text]


<h2>1DזE@\𐧌䂷CmVg[</h2>
@CmVg[̖͐\鎉̂ЂƂƂĂ̖̂قC̏dvȐIȖSDÂm@\̂ЂƂ́CZJhbZW[̎YVOi`B̐łDזEɑ݂G^pNêƃzXzp[[CɂzXt@`WCmVg[4,5-rX_CmVg[1,4,5-gX_ƃWAVOZ[ɕZJhbZW[̎Yi<a href="#R4"><sup>4-6)</sup></a>D
@ɁCCmVg[͍זEɂĂ̖̖̂̂̐ڈƂẴh}[NIȖSD_ʂ̈قȂCmVg[͂ꂼِ̓ɂقȂ鐶̖ɕzDāCقȂCmVg[ɂ͂ꂼٓIɌGtFN^[^pN݂DƂ΁CzXt@`WCmVg[4,5-rX_ɌPHhC^pŃCזEɂzXt@`WCmVg[4,5-rX_̋ǏIȔZx̏㏸ɂƂȂזEɃN[gD܂CzXt@`WCmVg[3-_ɌPXhCFyvehC^pŃCǏIȃzXt@`WCmVg[3-_̔Zx̏㏸ɂƂȂGh\[ɋǍ݂<a href="#R7"><sup>7)</sup></a>D̂悤ɁĈ̂̃CmVg[̈قȂǍ݂̓GtFN^[^pN̎ԓIɓٓIȃN[g\ɂC܂܂ȃ^pNK؂ȏꏊɓImȃ^C~OŃN[g邱ƂɂX̐ɒ炷D̓ɂCCmVg[͍זE̋ǏɂVOi`B̏XCb`Ƃċ@\CAĚ`▌_Ci~NXƂȂugtBbNȂǂ̕GȃJXP[hɒ炵肷D̂悤ɁCCmVg[͍זEIKlɃACfeBeB邱ƂɂזE@\𐧌䂷D
@̂قɂCCmVg[͂ق̎̑ÔƂĂ̋@\C܂CזEɂ鎉AюzIX^VXɂĂ߂ďdvȖSƂ炩ɂD܂CזEi̐C`l̋@\̐CזȆȂǁC܂܂ȐɊ֗^邱Ƃ炩ɂĂD̂悤ɁCCmVg[͍זE@\dvȈqƂȂĂD

<h2>2D܂܂Ȑ̖_Ci~NX𐧌䂷zXt@`WCmVg[4-_</h2>
@zXt@`WCmVg[4-_͍זEɂ鑶ݗʂ̂ƂCmVg[̂ЂƂłɂ炸C̋@\̏ڍׂɊւĂ͂܂ɑ̓䂪cĂDzXt@`WCmVg[4-_̓zXt@`WCmVg[ƂCCmVg[4ʂ_PI4Li[[ɂVKɍD܂ŁCoyɂĂ3ށCMނɂĂ4ނPI4Li[[肳Ă<a href="#R8"><sup>8,9)</sup></a>i<a href="#F2">}2</a>jDMނɂẮCPI4Li[[͍\ѐwIȓɂ^CvIIƃ^CvIIIɕނĂCꂼɃу2ނ݂DƂƂ̓^CvI݂C͂̂ɃCmVg[3ʂ_PI3Li[[ł邱ƂDPI4Li[[͂ꂼꂪقȂ鐶̖ɋǍ݂CƎ̋@\SƂ炩ɂĂD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@CmVg[4ʂ_PI4Li[[̍\</strong>
PI4Li[[ɂ̓^CvIIƃ^CvIII݂DqgɂāCPI4Li[[III͍זEɂzXt@`WCmVg[4-_̎YCPI4Li[[III̓SŴɂzXt@`WCmVg[4-_̎YSD^CvIIƂẮCGh\[уSŴɂzXt@`WCmVg[4-_̎Y𐧌䂷PI4Li[[IICсCזE邢̓Gh\[ɂzXt@`WCmVg[4-_̎YSƂĂPI4Li[[II݂D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/09/Nakatsu-5.e008-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2016/09/Nakatsu-5.e008-Fig.2.png&amp;caption=fig2-caption-text]

@CCmVg[4ʂE_zXt@^[[肳ĂCSac1hCʂĂ<a href="#R10"><sup>10)</sup></a>i<a href="#F3">}3</a>jDSac1͏ÉCсCזȄԂɉSW<a href="#R11"><sup>11)</sup></a> ɋǍ݂閌^pNłCזEуSŴɂčꂽzXt@`WCmVg[4-_̒E_SDÊɋǍ݂閌^pNǂ̂悤ɍזEуSŴ̃zXt@`WCmVg[4-_𐧌䂷̂C̕q@\͋c_̓IłCSac1ÊƍזEƂ̐ڐGʂɋǍ݂邱ƂɂgX̍זEɋǍ݂zXt@`WCmVg[4-_E_邱ƂoyꂨѓזEɂĎꂽ<a href="#R12"><sup>12,13)</sup></a>Dŋ߁CM҂܂ޕ̌O[v́CSac1͏ÊƍזEƂ̐ڐGʂ邢͏ÊƃSŴƂ̐ڐGʂďÊɗAĂzXt@`WCmVg[4-_CVXł鏬ÊɂĒE_邱Ƃo<a href="#R14"><sup>14-16)</sup></a>D܂CÊƃSŴƂ̐ڐGʂɋǍ݂CILVXe[^pNłOSBPƕ̂`ăSŴ̃tg\̌`Ɋ^邱ƂĂ<a href="#R17"><sup>17)</sup></a>DSac1hCق̃zXt@^[[̂Csynaptojanin <a href="#R18"><sup>18)</sup></a> Sac2 <a href="#R19"><sup>19)</sup></a> ̓GhTCg[VXoHɂăzXt@`WCmVg[4-_̃zXt@^[[Ƃċ@\邱ƂmĂD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@Sac1hCzXt@^[[̍\</strong>
qgɂẮCCmVg[E_Sac1hC3ނ̃zXt@^[[肳ĂDSac1͖ђʗ̈ďÊɋǍ݂DזEɂĂ͂ɃzXt@`WCmVg[4-_E_邱Ƃ悭mĂ邪C<em>in vitro</em>ɂĂ̓zXt@`WCmVg[4-_̂قzXt@`WCmVg[3-_zXt@`WCmVg[3,5-rX_Ȃǂɑ΂ĂE_DSac2͏GhTCg[VXoHɂăzXt@`WCmVg[4-_̒E_SDSac3͂ɃGh\[ɋǍ݂zXt@`WCmVg[3,4-rX_̒E_SDȂCsynaptojanin1synaptojanin2Sac1hCCmVg[̃zXt@^[[ł邪Cɂ͎ĂȂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/09/Nakatsu-5.e008-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2016/09/Nakatsu-5.e008-Fig.3.png&amp;caption=fig3-caption-text]


<h2>3DSŴɑ݂zXt@`WCmVg[4-_</h2>
@SŴ̓zXt@`WCmVg[4-_Lxɑ݂IKl̂ЂƂłDoyɂĂPI4Li[[łPik1SŴɂzXt@`WCmVg[4-_̎YS<a href="#R20"><sup>20,21)</sup></a>D<em>pik1</em>ɂĂ̓zXt@`WCmVg[4-_̗ʂ50قǌ邱ƂCPik1SŴɂĎYzXt@`WCmVg[4-_͍זEɂzXt@`WCmVg[4-_̑ʂ̖񔼕߂Ƃ<a href="#R22"><sup>22,23)</sup></a>D܂C<em>pik1</em>͒vƂȂ邱ƂCPik1̋@\͍זEɂăzXt@`WCmVg[4-_̎YSStt4Ƃ͓ƗĂC@\IɏdȂƍlĂDPik1Frq1ɈˑăSŴɃN[g<a href="#R24"><sup>24)</sup></a>DPik1̃SŴւ̃N[gArf1ɂĂ䂳D<em>pik1</em>ɂĂ̓SŴ̌`Ԃُ̈CזẼ\\[ɑtE̒fЉCזËُȂǂD܂CzXt@`WCmVg[4-_̓SŴ̏EAɂĕK{łD
@זEɂẮCPik1̃zOłPI4Li[[IIISŴɂzXt@`WCmVg[4-_̎YSDPI4Li[[IISŴɂzXt@`WCmVg[4-_̎YɊ֗^Ƃ񍐂DPI4Li[[IIĨSŴւ̋Ǎ݂ɂ́CPik1ƓlɁCoyFrq1̃zONCS1Ƃ΂frequeninArf1֗^ƍlĂ<a href="#R25"><sup>25,26)</sup></a>D܂CPI4Li[[IIǏ^pNłACBD3̃mbN_EɂPI4Li[[IIIזEɎU݂ƂCACBD3܂PI4Li[[IIĨSŴւ̋Ǎ݂Ɋ֗^Ƃ񍐂<a href="#R27"><sup>27,28)</sup></a>D
@SŴɂāCzXt@`WCmVg[4-_͎X̃GtFN^[^pNN[g邱Ƃɂ肻̋@\𐧌䂷DNX̃A_v^[^pNłAP1́CzXt@`WCmVg[4-_ɂSŴɃN[g邱Ƃɂςׂ݉ƂȂ^pN̑IʂуNX핢Ě`𑣐iCSŴ̏EA𐧌䂷<a href="#R29"><sup>29)</sup></a>DGOLPH3܂CzXt@`WCmVg[4-_ƌ邱ƂɂSŴɃN[gCAN`i̐ăSŴ̌`Ԍ`Ɋ֗^<a href="#R30"><sup>30,31)</sup></a>D܂CAɊ֗^^pN̓zXt@`WCmVg[4-_ɈˑăSŴւƋǍ݂邱Ƃɂ@\𔭊DCERT͏ÊSŴւ̃Z~h̗AS^pNł邪CCERT̂PHhCSŴɂăzXt@`WCmVg[4-_ٓIɔFČ邱ƂɂCSŴւ̃Z~h̗A𐧌䂷<a href="#R32"><sup>32)</sup></a>D̂قCFAPP1FAPP2̓ORXtBS̗ASC͂Cꂼ̂PHhCSŴɂăzXt@`WCmVg[4-_F邱Ƃɂ肻̗A𐧌䂷DɁCILVXe[^pNłOSBP͂PHhCCSŴɂăzXt@`WCmVg[4-_F邱ƂɂSŴւƋǍ݂DOSBP͏ÊƃSŴƂ̖ڐGʂɋǍ݂CÊRXe[AƓɁCSŴzXt@`WCmVg[4-_AD

<h2>4DזEɑ݂zXt@`WCmVg[4-_</h2>
@זE̓SŴƂȂŃzXt@`WCmVg[4-_̖Lxɑ݂鐶̖łDoyɂčזEɂzXt@`WCmVg[4-_̎YStt4SDStt4̓veCLi[[C̑jQ܂łstaurosporineɊ󐫂ψّ̂̃XN[jOɂPꂽ<a href="#R33"><sup>33)</sup></a>DStt4Efr3Ypp1ƕ̂`邱ƂɂזEɋǍ݂zXt@`WCmVg[4-_Y<a href="#R34"><sup>34)</sup></a>D<em>stt4</em>`q̉x󐫕ψق}`q̎YƂĒPꂽђʌ^̍זE^pNłSfk1܂CStt4̍זEւ̃N[gɊ֗^邱Ƃ񍐂Ă<a href="#R35"><sup>35)</sup></a>D`wICזEwICwIȉ͂ɂCStt4͍זEɂzXt@`WCmVg[4-_̎YɂĕK{ł邱ƂĂ<a href="#R23"><sup>23)</sup></a>D<em>stt4</em>ɂĂ͍זEɂzXt@`WCmVg[4-_̑ʂvƂȂD́CSŴɂăzXt@`WCmVg[4-_YPik1̋ɂ背XL[ȂƂCStt4Pik1͓PI4Li[[łȂ@\Iɂ͏dƗĂ邱ƁCāCזEƃSŴ̃zXt@`WCmVg[4-_v[͈قȂ邱Ƃꂽ<a href="#R23"><sup>23)</sup></a>D<em>stt4</em>`q̉x󐫕ψي̓veCLi[[CVOi`BnCAN`iCזEǂȂǍזEɂzXt@`WCmVg[4,5-rX_̐@\ɖڂ@\ɈُƂCStt4ɂYzXt@`WCmVg[4-_̓zXt@`WCmVg[4,5-rX_̑ÔƂĂ̖SƂ炩ɂĂDȂC<em>stt4</em>`q̉x󐫕ψيɂĂ͉tĚ`ԂɈُ킪݂邱ƂCזEɑ݂zXt@`WCmVg[4,5-rX_Ƃ͂񂵂Ēڂ̊֌ŴȂ̖ɂ@\݂̑ĂD
@זEɂĂPI4Li[[IIIStt4̃zOƂċ@\DPI4Li[[IIIR[hcDNÃN[jO1996Nɕ񍐂ꂽ<a href="#R36"><sup>36)</sup></a>DPI4Li[[III̓A~m_z̑@\IɂStt4ƓlɍזEɂzXt@`WCmVg[4-_̎Y@\SƗ\zꂽDCAMIeVIIêւ̎ĥ̂zXt@`WCmVg[4,5-rX_čC̋ƂĕKvȃzXt@`WCmVg[4-_̎YPI4Li[[III֗^邱Ƃ񍐂ꂽ<a href="#R37"><sup>37,38)</sup></a>Cڍׂȋ@\͂͒xXƂĐi܂ȂD̗R̂ЂƂɁCPI4Li[[III̋Ǎ݂Ȃ炭sł邱ƂD܂ŁCPI4Li[[III̍זEւ̋Ǎ݂f[^͓Ă炸CɁCÉCSẂCjɋǍ݂ȂǏ񏥂Ă<a href="#R8"><sup>8)</sup></a>D
@2012NC܂ŊJnRhłƐMĂMetR[hRh͊JnRhł͂ȂCScDNAƂĂzɂN[59A~m_cR[hz񂪌Ă邱Ƃ<a href="#R39"><sup>39)</sup></a>DɁCVPI4Li[[III^pNƂEFR3A/BTTC7A/B肳CSPI4KIII͂̃^pNƕ̂`邱ƂɂזEɋǍ݂邱ƂꂽDPI4Li[[IIImbNAEgזEɂāCNX핢Ě`ُ̈AN`ǐ`ُ̈ȂǍזEɂzXt@`WCmVg[4,5-rX_̌ɂƂȂُ킪݂ꂽƂCPI4Li[[III͍זEɑ݂zXt@`WCmVg[4,5-rX_̑ÔłzXt@`WCmVg[4-_̎YɕK{ł邱ƂꂽD܂CPI4Li[[IIImbNAEgזEɂĂ͍זEɂRXe[̌זEɋǍ݂^pNُ̈IȋǍ݉ƂCPI4Li[[IIIɂYzXt@`WCmVg[4-_͍זẼACfeBeB̊mɏdvȖSƂ炩ɂꂽ<a href="#R39"><sup>39)</sup></a>DɁCStt4̍זEւ̃N[g𑣐iSfk1̃zOłTMEM150A͂PI4Li[[IIIƌזEɂzXt@`WCmVg[4-_̎YɊ^邱<a href="#R40"><sup>40)</sup></a>CāCVPI4Li[[IIǏ^pNƂFMA126A/BP<a href="#R41"><sup>41)</sup></a>CPI4Li[[IIIEFR3A/BCTTC7A/BCTMEM150ACFAM126A/Bƕ̂`邱ƂDFAM126AiʖFHyccinj͐_o̒E𐶂`̎ł锒WXgtB[̌`q̎YłCPI4Li[[IIÎזEɂzXt@`WCmVg[4-_̎Y~Ǧ`ɂďdvȖSƂ炩ɂꂽ<a href="#R41"><sup>41)</sup></a>D̂قCזEɑ݂zXt@`WCmVg[4-_̓zXt@`WCmVg[4,5-rX_ƂƂɍזEɂ镉ďׂ`Ɋ^CX̃^pN̍זEւ̃N[g`l̋@\̐Ɋ֗^邱Ƃ񍐂ꂽ<a href="#R42"><sup>42)</sup></a>D

<h2>5DzXt@`WCmVg[4-_ɂ閌ڐGʂɂ鎉A̐</h2>
@܂ŁCזEɑ݂zXt@`WCmVg[4-_̓zXt@`WCmVg[4,5-rX_̑ÔƂĂ̖ȋ@\łƍlĂDȂߔNɂȂCzXt@`WCmVg[4-_͍זEɂ鎉A̐CזEɂ鎉zIX^VX̐ɂ߂Đ[֘AƂXɖ炩ɂDזEɂ鎉Aɂ́CugtBbNɂ萧䂳鏬EAɈˑIȌoĤقCEAɔˑIȌoH݂C͎A^pNilipid transfer proteinjƑ̂Ã^pNɂ萧䂳DA^pN͎ƌ郊KhhCCꂪa|PbgƂċ@\邱Ƃɂ̎͂݁Cێ邱ƂłD̓ɂCA^pN͈̖̐玉𒊏oC̎ʂ̖̐ւƗA邱ƂɂCقȂ鐶̖̂̎A}邱ƂłD

<h2>6DILVXe[^pNt@~[ɂzXt@`WCmVg[4-_A̐</h2>
@ILVXe[^pNt@~[͎A^pN̂ȂłrI傫ȃt@~[\Cyꂩqgɂ܂ŕۑĂ<a href="#R43"><sup>43)</sup></a>D̃vg^CvłOSBP̓ILVXe[Ɍ^pNƂ1984Nɓ肳ꂽDɑ̃zȎ݂C݂ł́Coyɂ7Cqgɂ12̃ILVXe[^pNt@~[̃o[݂̑mFĂ<a href="#R44"><sup>44)</sup></a>DILVXe[^pNt@~[ɂ͋ʂăKhhC݂C̃hCa|PbgƂċ@\邱Ƃɂ̎͂<a href="#R45"><sup>45)</sup></a>D́CׂẴILVXe[^pNt@~[̂KhhC͋ʂăXe[ioyɂĂ̓GSXe[CזEɂĂ̓ILVXe[уRXe[j͂܂ƍlĂCŋ߂ł́CzXt@`WCmVg[4-_zXt@`WZƓٓIɌ郊KhhC݂̑ĂDɁCILVXe[^pNt@~[ɂ͍זEɂǍ݂K肷hC⃂`[t݂CȂłCFFAT`[tƂ΂z񂪑݂DFFAT`[t͏E̖^pNłVAP-AVAP-B̂MSPhCƌCɂILVXe[^pNt@~[͏E̖ɌqD܂CقڂׂẴILVXe[^pNt@~[ɂPHhC݂CAׂ̖̔F₻ꎩ̂̋Ǎ݂ɂĂ߂ďdvȖSD
@̂悤ȍ\ɂCILVXe[^pNt@~[͋@\Iɂ̓Xe[̗̎A⎉zIX^VX̐Ɋ֗^Ɨ\zĂDCg^pNƂĔKhhC<em>in vitro</em>ɂă|\[ƍƁC̃|\[瑼̃|\[ւ̃RXe[̗AF߂ꂽƂCILVXe[^pNt@~[̓RXe[Ȃǂ̗̎AɊ֗^\ꂽDCoyp͂ɂẮCXe[̗Ał͂ȂzIX^VXɊ֗^Ƃ񍐂VOi`BɊ֗^Ƃ񍐂ȂCזExɂڍׂȋ@\̉͂͒xĂD

<h2>7DÊƃSW̖Ƃ̐ڐGʂɂzXt@`WCmVg[4-_ƃRXe[̌A</h2>
@oyɂILVXe[^pNt@~[̃o[łOsh4́CȑOC<em>in vitro</em>ɂ郊|\[pAbZCɂăXe[̃|\[瑼̃|\[ւƗA銈ƂmĂ<a href="#R45"><sup>45)</sup></a>D2011NCގ<em>in vitro</em>AAbZCnpāCOsh4ɂXe[̗AzXt@`WCmVg[4-_ɂٓIɑjQ邱ƁCāC̃zXt@`WCmVg[4-_ɂXe[̗ȂjQ̓zXt@`WCmVg[4-_Osh4̃KhhCɓ荞ނƂɂhRjQł邱Ƃoꂽ<a href="#R46"><sup>46)</sup></a>D܂COsh4̃KhhC̓Xe[łȂzXt@`WCmVg[4-_KhƂ邱ƂCۂɁCOsh4<em>in vitro</em>ɂăzXt@`WCmVg[4-_A銈ƂꂽD̃zXt@`WCmVg[4-_Osh4̐VȃKhłƂACfBÁCKhhCƃzXt@`WCmVg[4-_Ƃ̋X\͂ɂؖꂽ<a href="#R46"><sup>46)</sup></a>DOsh4̃KhhCɂ̓Xe[ƃzXt@`WCmVg[4-_̂ǂ\ł邪Cǂ炩݂̂荞ދԂ݂ȂƂD̃f[^ƂɁCOsh4̓Xe[ƃzXt@`WCmVg[4-_Âł͂Ȃƒ񏥂C̉́C2NCO[vɂ蓮זEpďؖꂽD
@2013NCOsh4̚MނɂzOłOSBPCSŴɑ݂zXt@`WCmVg[4-_ƂPHhCɂ錋CсCE̖^pNłVAPƂFFAT`[tɂSŴƏÊƂ̐ڐGʂɋǍ݂CÊčꂽRXe[SŴւƗAƓɁCSŴɖLxɑ݂zXt@`WCmVg[4-_ÊւƋtA邱Ƃؖꂽ<a href="#R14"><sup>14)</sup></a>D̗Ǎ`͌AłCA鎉͈̕łD܂CRXe[͏ÊSŴցCzXt@`WCmVg[4-_̓SŴ珬ÊւƗAĂD

<h2>8DÊƍזEƂ̐ڐGʂɂzXt@`WCmVg[4-_ƃzXt@`WŽA</h2>
@זEzXt@`WCmVg[4-_LxȐ̖ł邪CłzXt@`WCmVg[4-_̗AɏdvȖSƂ炩ɂꂽDORP5ORP8͂ق̃ILVXe[^pNt@~[̃o[Ƃ͈قȂ薌ђʗ̈CÊɋǍ݂<a href="#R43"><sup>43)</sup></a>DORP5͏Êƃ\\[Ƃ̐ڐGʂɂNPC1ƌ邱ƂɂRXe[̑ӂїAɊ֗^邱Ƃ񍐂Ă<a href="#R47"><sup>47)</sup></a>CORP8̋@\ɂĂ͂قƂǒmĂȂDŁCORP5ORP8ƔrI̍Osh6Osh7̓Xe[ł͂ȂzXt@`WZ̗AǂƂ񍐂ȂĂ<a href="#R48"><sup>48)</sup></a>CזEɂORP5邢ORP8̋@\͂̋Ǎ݂܂߉𖾂ĂȂD
@ORP5ORP8HeLaזEɂďÊƍזEƂ̐ڐGʂɋǍ݂C̋Ǎ݂́CN[ɑ݂PHhCɂזEɑ݂zXt@`WCmVg[4-_̔Fɂ̂ł邱Ƃ炩ɂꂽD@\m邤ŁCORP5邢ORP8̃KhƂȂ鎉̓͌ȂDŁCORP5̃KhhC𓮕זEɔ̂Cʕ͖@ɂ茋Ă鎉݂̓ƂCzXt@`WCmVg[4-_уzXt@`WZIȃKhƂē肳ꂽD́CORP5ORP8ɔrI̍Osh6Osh7Xe[ł͂ȂzXt@`WZKhƂƂ<a href="#R48"><sup>48)</sup></a> ƈvD<em>in vitro</em>ɂ郊|\[AAbZCє|{זEp@\͂ɂCORP5ORP8̓zXt@`WCmVg[4-_ƃzXt@`WŽA}邱Ƃ<a href="#R16"><sup>16)</sup></a>DȂ킿CORP5ORP8́C1jזEɑ݂zXt@`WCmVg[4-_ƂPHhCɂ錋ďÊƍזEȂƂߖڐGʂ`C2jPI4Li[[IIIɂYꂽzXt@`WCmVg[4-_זE炻ꎩ̂̂KhhCւƈ͂݁C3jzXt@`WCmVg[4-_ÊւƗADÂāC4jÊɂčꂽzXt@`WZƌC5jzXt@`WZזEւƋtAi<a href="#F4">}4</a>jD̂悤ɁCzXt@`WCmVg[4-_זE珬ÊւƗA邱ƂɂCzXt@`WZ̏ÊזEւ̗ADȂ킿CORP5ORP8ɂzXt@`WZ̗A̓zXt@`WCmVg[4-_쓮Ă̂łD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@ORP5ORP8ɂzXt@`WCmVg[4-_ƃzXt@`WŽA̐</strong>
זEɂPI4Li[[IIÎɂ荇ꂽzXt@`WCmVg[4-_ORP5ORP8̂KhhCɈ͂܂ꏬÊւƗADCÊɂčꂽzXt@`WZORP5ORP8ɂזEւƋtADזEƏÊ̂ɂ̓zXt@`WCmVg[4-_̔Zxz݂CɂzXt@`WZ̋tA\ɂȂD
PI4PFzXt@`WCmVg[4-_CPSFzXt@`WZCPIFzXt@`WCmVg[D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2016/10/Nakatsu-5.e008-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2016/10/Nakatsu-5.e008-Fig.4.png&amp;caption=fig4-caption-text]

@ł́C̎A͂̕ǂ̂悤ȕq@\ɂ̂낤H@ɂ̓zXt@`WCmVg[4-_dvȌɂĂDzXt@`WCmVg[4-_͍זEуSŴɖLxɑ݂D́CזEɋǍ݂PI4Li[[IIICсCSŴɋǍ݂PI4Li[[III̍pɂDŁCÊɂ̓zXt@`WCmVg[4-_͂قƂǑ݂ȂD́CÊɋǍ݂zXt@`WCmVg[4-_̃zXt@^[[łSac1̍pɂD܂CזEуSŴƏÊƂ̂ɂ̓zXt@`WCmVg[4-_̔Zxz݂邽߁CzXt@`WCmVg[4-_͍ZxłזEуSŴZxł鏬ÊւƈɗADꂪCzXt@`WZRXe[̋tAC܂CÊזEуSŴւ̗AK肷CƂfłD̃f́CזEōꂽzXt@`WCmVg[4-_ȂÊőӂ̂Ƃʂ̖DȂ킿CzXt@`WCmVg[4-_זE珬ÊւƗA͂Cʂ̎̋tAɗpĂ邩łD

<h2></h2>
@zXt@`WCmVg[4-_͓זEɂĂƂCmVg[̂ЂƂłCSŴזECāCGhTCg[VXoH\IKlɂẮCugtBbN̐ɌȂCmVg[ƂĒmĂDȂCȊÕzXt@`WCmVg[4-_̂{̋@\ɂĂ͂قƂǂ킩ĂȂDƂɁCזEɂĂ͒PɃzXt@`WCmVg[4,5-rX_̑ÔƂĂ݈̑Ӌ`݂̂mȋ@\ƂĔFĂD̂悤ȔwîƁCzXt@`WCmVg[4-_̓ILVXe[^pNt@~[ɂ閌ڐGʂ̌AɕK{̖SƂ炩ɂꂽD̃zXt@`WCmVg[4-_ɂ쓮鎉̌A̕q@\␶IȈӋ`ɂĂ͂܂܂sȓ_Dŋ߁CzXt@`WZ̑ӈُ悷Lenz-MajewskiǌQɂāCILVXe[^pNt@~[zXt@`WCmVg[4-_ƃzXt@`WŽA֗^\ꂽ<a href="#R49"><sup>49)</sup></a>DɁCזESŴłȂCGh\[ƏÊƂ̐ڐGʂɂĂzXt@`WCmVg[4-_̊֗^閌_Ci~NX̐@\炩ɂ<a href="#R50"><sup>50)</sup></a>DāCILVXe[^pNt@~[̂قɂڐGʂA𐧌䂷^pN݂邱Ƃ炩ɂĂD̂Ȃ͂ɂCzXt@`WCmVg[4-_ɂ閌_Ci~NX̐▌ڐGʂ݂ȎÂ݁C̐@\w𖾂邱Ƃ҂D

<h2> </h2>
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</ol>
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