]玿̑w\̌`ɂj[̈ړт̈Ӌ`

<strong> </strong>
ic`mww Uwj
emailF<a href="mailto:kazunori@keio.jp"></a>
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̈Zr[, <strong>6</strong>, e004 (2017)@<a href="http://dx.doi.org/10.7875/leading.author.6.e004">DOI: 10.7875/leading.author.6.e004</a>
Kazunori Nakajima: <strong>Neuronal migration during layer formation in the cerebral cortex.</strong>

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<h2>v </h2>
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<h2>͂߂</h2>
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@ȂMނ̔]̃j[͎YꂽʂړĂ\`̂낤H@ߔŇɂC]ƂgD\z邤Ńj[Ɉړ邱Ƃ̈Ӌ`_Ԃ݂ĂDj[̈ړƂߒɂזÊ̊֌WZbgCK؂Ȑ̂ƃj[̂̐V֌W\z邱Ƃ\ɂƂ_C̈Ӌ`̂ЂƂƍlD܂Cj[ړ邱ƂɂȍזEOɔICReLXgɈˑIȐn\ɂƂӋ`ƍlD
@ȉɂẮC܂C̑]玿ɂăj[̈ړɂw\`ߒɂĉDÂāCŋ߁Cj[̈ړ͂̂̂̑wɓٓIȃTu^CvɓK؂ɕ邤łdvȖƂ炩ɂĂ̂ŁCɂĂ̒mЉDȂC̃r[ɂĂ͊ȒP̂߁g]玿hƂԂCۂɂ͑̌̓}EX́g]V玿hōs꓾ĂmłD

<h2>1D]玿̔ɂj[̈ړсginside-outhlł̑w\̌`</h2>
@]玿̃j[ɂ́C傫ċj[Ɨ}j[2ނ݂Dj[͑]玿̔]̋߂ɂĎYC]̕\ʂɂނĕˏɁi@̕Ɂjړ̂ɑ΂C}j[͑]玿̊OiI]邢͊Ԕ]̈ꕔjɂĎYC]̕\ʂɕsɁiڐ̕Ɂjړđ]玿ɐiD̈ړl̏ڍׂɂĂ͍ŋ߂̂̑ɂďڏqĂ̂<a href="#R2"><sup>2-4)</sup></a>Cł͊Tv݂̂D
@]iVj玿͔]̕\ʂɕs6̑wiIw`VIwjȂw\D̂̂̑w͂ꂼɊ܂܂\Iȃj[̌`Ԃ⎲˂̗lɂÂ<a href="#R5"><sup>5)</sup></a>CƂ΁CIVw͂Ɏ]玿ւ̓͂rIȐ̃j[\CIIw/IIIw͑]玿̗̖̂A鐍̍זEȍ\j[łD]玿ɂďꂽ́CVwVIw]玿̊OiҐC]CȂǁjւƏo͂D]玿̗̖̂̂̂삪ꂼL̋@\ƂɑΉāCƂ΁C1^ł͑Vw1oł͑IVwȂǁĈ̂̑w̑ΓIȌij[̐j̖͗ɂ傫قȂD
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<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@]玿ɂw\̌`̉ߒ</strong>
}EXَ̑e̔]̑]̊fʂ̖͎}D]玿ɂĂƂɎYj[́C]̕\ʂ̋߂̕Ӊтɑ݂Cajal-RetziusזEƁC[ʒuɋǍ݂Tuv[głD̂̂C]тɂĎYꂽj[́C]̕\ʂ̑ւƈړĕӉт̒ňړCTuv[gƕӉтƂ̂ɔ玿ginside-outhlō\zDԑт͔玿ɏo肷鎲s镔ʂłD̒ȍ~ɂȂƁC]т̂]̕\ʂ̑ɔ]тёɐזE~ϑт肳悤ɂȂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/07/Nakajima-6.e004-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2017/07/Nakajima-6.e004-Fig.1.png&amp;caption=fig1-caption-text]

@ˏۂɂăR[VɂړĂj[́C̐擱ˋN̐[]̕\ʂ̒̕ӉсȋIwjɓBƈړlωDȂ킿C擱ˋN̐[ӉтɓB܂ܓˋNZkCזÊˏۂ痣ĈCɕӉт̒܂ňグړƍlĂD̉ߒ̓^[~igXP[VƂ΂<a href="#R8"><sup>8)</sup></a>i<a href="#F2">}2a</a>jD̑IIw`VIw\鋻j[͂̉ߒɂԂ߁CʂƂāCj[͎YꂽɕӉт̒ɂĔ]̕\ʂ̑ɐςݏオĂiginside-outhlji<a href="#F1">}1</a>jDȂ킿Ĉ̂̑w\j[͐_oזEi_oOזEj̕ɂj[ƂĎYꂽȂ苤ʂD̏̑IIw`VIw̃j[zu镔ʂ͔ɂĂ͔玿Ƃ΂D

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iajReelin͈ړĂj[̏I_ɂă^[~igXP[VNƂƂɁCj[̂̐ڒߓIɑDReelinƑ]玿ɂj[̔zu͑傫đŜƂċt]D
ibjj[̈ړ̓rReelinُIɋƂɐÏW̌`̉ߒDj[ƂĂ̎ÝCFCIWFCsNF̏ɑDj[Reelin̈̎͂ňړ邽߁CxYꂽj[قǂiS̋߂jɔzuD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/07/Nakajima-6.e004-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2017/07/Nakajima-6.e004-Fig.2.png&amp;caption=fig2-caption-text]

@Ӊтɂ͂̎ނ̃j[Ǎ݂邪C̑\IȂ̂Cajal-RetziusזEƂ΂j[łi<a href="#F1">}1</a>C<a href="#F2">}2a</a>jDCajal-RetziusזEReelinƂ^pNזEOɕ債Cginside-outhlł̑w\̌`̉ߒ𐧌䂷<a href="#R9"><sup>9)</sup></a>DCajal-RetziusזE͏ô̂ɏƂĂCɂ݈̂ߓIɑ݂dvȃj[łDCajal-RetziusזE͑]玿̃j[̂Ȃł͂ƂɎYj[̂ЂƂł邪C̔]тɗR̂ł͂ȂC]玿̊OŎY]̕\ʂɕsɈړđ]玿ɐi<a href="#R10"><sup>10)</sup></a>D
@ƂɎYj[ɃTuv[gƂ΂j[C玿̂ɐ[ɋǍ݂i<a href="#F1">}1</a>jDTuv[g͎瓊˂ꂽۂ̑IVw̃j[ɂƂǂ܂̈ꎞIȕWIɂȂdvȃj[ł邪C͂ô̂ɂقƂǂDc̃Tuv[g͑VIbw\Đ_oHlbg[N̈ꗃSCCajal-RetziusזEƂȂő]玿̔ɏdvȖSj[̂قƂǂw\̌`̂邱Ƃ͋[D

<h2>2DړĂj[̕Ӊт̒ɂWёI</h2>
@]玿ɂginside-outhlł̃j[̔zű@\炩ɂɂẮC̉ߒj]Rǂ̓ˑRψك}EXł<em>reeler</em>}EX̉͂dvȖSD<em>reeler</em>}EX̑]玿̑w\͑傫ĂCŜƂċt]igoutside-inhjƂƂi<a href="#F2">}2a</a>jCÂ璍ڂĂiCۂɓT^Iȁgoutside-inhl݂̂͑]玿̌㕔݂̂łC]玿̑OɂĂ͑w\sĂɂȂƂقmƎvjD<em>reeler</em>}EXɂĂ͈ړĂj[ړ̑łˏOAۂɈُ킪ƍl̂ÓTIȍlłC1995NČ`qł<em>reelin</em>`q肳lςD<em>reelin</em>`qɔj[͈ړĂj[łˏOAłȂCӉтCajal-RetziusזEł߂ł<a href="#R9"><sup>9,11)</sup></a>i<a href="#F2">}2a</a>jDCajal-RetziusזE͈ړ̂܂ɓ˂̏I_ɑ݂j[łƂCReelin͈ړĂj[ɑ΂ړ~̃VOi^pNłƍl悤ɂȂD
@ɁC]̕\ʂɂނĈړĂj[Reelinɂӂƒ~ƍl΁Cginside-outhlł̃j[̔zu͗₷DłɁCړ̓rɂĈُIReelinsꂽDReelinړ~̃VOi^pNłȂCReelinɂӂĈړ~j[a؂邱Ƃ҂ꂽDƂ낪Cʂ͗\zƂ͈قȂĂDړĂj[͂ɏa؂̂ł͂ȂC̃j[łꂢȊۂÏW`̂ł<a href="#R12"><sup>12)</sup></a>i<a href="#F2">}2b</a>jDÏW̕\ʂ͂Ȃ߂炩ŁCj[͈ړ\čEɑ݂̈ʒu𒲐ȂWƂlȂDCÏW̒S߂͍זÊrCُIɔReelinɔZkċǍ݂DזÊrꂽ̒S̕ɂ́CWĂj[̐擱ˋN݂̂iC͎ˋNƂĐnĂDȂ킿CӉтƂ悭̈悪ÏW̒SɌ`ꂽ̂łDɁCړĂj[͂̋ÏWɂāginside-outhlŔzuĂDȂ킿CƂ炫j[͂ɂĂj[zċÏW̒SReelinz̈ɖʂʒuňړƂߒԂ邱ƂɂÏW͑傫Ȃ邱Ƃi<a href="#F2">}2b</a>jDӉт̂悤ɁCړĂj[̍זÊiȂ̈悪`邱ƁC܂C̒íjɂāginside-outhlŃj[zu邤ŁCCˏOA̐[CCajal-RetziusזEȂǂ̔]̕\ʂ̋߂̍\͕svłCReelinƂ^pN΁ginside-outhl͍Č邱ƂꂽD
@ُIɔReelinɑ΂ړĂj[ċÏW`邱Ƃ킩CReelin̖{̔ʂłӉт̒ɂĈړĂj[͋ÏW`̂낤H@炽߂Ĕ]̐ؕЂώ@ƂCɕӉт̒CȂ킿C玿̂Ƃ\w̕ɖñj[\m̕ŖẄ悪݂邱Ƃ킩C玿сiprimitive cortical zoneFPCZjƖꂽ<a href="#R13"><sup>13)</sup></a>D
@Reelinz̈iӉсjɂ͈ړĂj[̐擱ˋN͐ił̂ɂȂזÊ͐iłȂ̂CړĂj[ReelinɂӂƂǂ̂悤Ȃ݂ŋÏW`̂CɂĂj[xɋÏẄƂ炫j[͂ȂeՂɒʉ߂ł̂CȂǁCC𖾂ׂdvȓ_邪Cُ̋̌ʂReelin̐wIȋ@\l邤Ŏɕxނ̂ƍlD
@āCReelinPȈړ~̃VOił͂ȂƂāCł́CĂ̂ł낤H@ړ̓rɂReelinƃj[ÏW`ƂCj[ǂ̐ڒ𑝋\lꂽDCُ̋̎́Cj[̂̐ڒ𑝋Ƃ\̂قCReelinɂӂꂽj[͂̍זEO甽悤ɕωāi̖̒̂悤ɁjÏW`Ƃ\ےłȂDŁCِ<em>reeler</em>}EX̑]玿̃j[𕪎U|{ReelinYƂsꂽĎʁCɃj[ÏW`邱ƂmFCReelin̓j[̂̐ڒ𑣐i@\Ƃ킩i<a href="#F2">}2a</a>jD̋ÏW̌`NJhwĂCNJhwɑ΂j[̐ڒ͂Reelinɂ葝邱Ƃ͌qԗ͌ɂ蒼ړIɏؖꂽ<a href="#R14"><sup>14)</sup></a>D͈̑ߓIȂ̂łC΂炭ReelinY܂̃xɂǂDڒ͂̑ߓIł闝R͕sł邪ClדIɑƃj[̍ŏIIȔzu͗ꂽDCɂĂj[ÏWƂ炫j[ʉ߂ł錻ۂƊ֌ŴȂD
@ł́CӉт̒ɂĂ킴킴j[ߓIɋÏW邱Ƃɂ͂ǂ̂悤ȈӋ`̂H@_ł͕sł邪CזÊǂ玿тɂčxɐڒċÏW邱Ǝ̂ɂȂ炩̐wIȈӋ`ƑzDړĂj[͈ړIOɂقڊ1ƂԂɂ킽茴玿тɂƂǂ܂邪ĈɉNĂ̂낤H
@gقڊ1h玿тɂƂǂ܂ƂƂ́CɂĂj[ƂƂ炫j[玿тɂč݂邱ƂӖD炪ʂ̑wɔzu悤ɁC玿тɂăj[Iʂ\zD
@́CȂƂꕔ̃j[ɊւẮCŏIIɔzuׂwƂɑIʂ悤Cړ̓rɂĂłɉ^ÂĂ邱ƂCߋ̔|{ɂ莦ĂD̓Iɂ́CӉт̒ɓB܂̈ړĂj[P̍זEɂ܂ŕÛC񂷂`[ûȂŌ܂ܔ|{sꂽD̔|{ɂẮCɂЂƂ̑傫ȋÏW򂪌`Ă邪C̓̍\𒲂ׂʁCIVwɔzuׂj[́C肳ɎYꂽj[Ƃɔ|{ꍇC邢́C肠ƂɎYꂽj[Ƃɔ|{ꍇCÏW̒S߂ɑIʂċǍ݂<a href="#R15"><sup>15)</sup></a>D̂悤ȑIʂ̉ߒ玿тɂċNĂ\́CC؂鉿lƎvDɂĂCVYړĂj[̂̊֌WReelin̐̂ƂœK؂ɍ\zĂŁCӉт̒̌玿тƂꏊ͓ʂȖƍlD

<h2>3Dj[̈ړReelinɂ萧䂳</h2>
@Reelinj[̋ÏWЂNƂ͖炩ł邪CCŋ߂̌ɂCj[̈ړ̂̂Reelinɂ萧䂳邱Ƃ킩ĂD
@R[VɂړĂj[́CŌɃ^[~igXP[VƂ΂ړlɕωĈړD̃R[V^[~igXP[Vւ̈ړl̕ϊCReelinɂЂN邱Ƃ킩Ăi<a href="#F2">}2a</a>jD̕ϊɂReelin̉ɂăCeO邱ƂƂĕKv<a href="#R16"><sup>16)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/6008" target="_blank">V_r[</a> łfځjCɁCNJhwуlN`-At@fBn֗^<a href="#R17"><sup>17)</sup></a>DRtBAN`זEinɂj[̈ړ̐ɂĂ񍐂Ă<a href="#R18"><sup>18)</sup></a>D^[~igXP[Vɂړ̋͂킸\młC玿ǂ̑Ŝ̌CȂ킿Cj[ړ鋗̑Ŝ炷Ƃ킸ł邪C̃^[~igXP[V̉ߒjQƁginside-outhlł̃j[̔zu͊SɗCɎYꂽj[ƂƂYꂽj[Ƃ݂ċǍ݂悤ɂȂ<a href="#R13"><sup>13)</sup></a>D̂ƂCړ̋ƂĂ͂킸ł邪C^[~igXP[V̉ߒ玿w̌`ɂĔɏdvȂ̂ł邱ƂD

<h2>4Dj[̓ٓIȃTu^Cvւ̕ɂזEړ̈Ӌ`</h2>
@āC]玿̂̂̂̑wɂ͂ꂼIȃTu^Cṽj[Ǎ݂DȂ킿CX̃j[̐ۂ̘Al܂ތ`Ԃ┭}[J[`qȂǁĈ̂̑wƂɋʂmĂ<a href="#R5"><sup>5)</sup></a>D]̋߂ɂăj[ƂĎYꂽɈˑginside-outhlł̍ŏIIȔzũp^[񂪂݂ƁCj[ƂĎY^C~OƂ炪ŏIIɕTu^CvƂɂ͑ւD̂߁C]̋߂ɑ݂_oזEi_oOזEj́Ciނɂꂵɂ̕\ωCɈقȂTu^Cṽj[î̂CɃOAזEjYƂ킩₷lʂɎ󂯓Ă<a href="#R19"><sup>19)</sup></a>i<a href="#F3">}3a</a>jDۂɁC_oזEi_oOזEj̕\ɕωߒSזEɓݐ̋@\CɉeڂזEÕVOi肳<a href="#R20"><sup>20,21)</sup></a>D

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@]玿ɂj[̃Tu^Cv̌̋@\Ɋւ2̍l</strong>
iaj_oזEi_oOזEjזE̕\̐isɂƂȂω邱ƂɂCقȂTu^Cṽj[YD
ibjYꂽ̃j[͂܂Tu^CvŏIIɌ肳Ă炸Cj[̐nɂƂȂזEOȂǂ̉eɂ̃Tu^Cṽj[ւƕD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/07/Nakajima-6.e004-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2017/07/Nakajima-6.e004-Fig.3.png&amp;caption=fig3-caption-text]

@Cꂼ̃Tu^Cṽj[ɓٓIɔ}[J[ƂĂg^pN͂̑]ʈqł邪ĈȂɂ̓Tu^Cv̌肻̂̂̐ɂ̂܂܂邱Ƃ킩Ă<a href="#R22"><sup>22,23)</sup></a>iƂ΁CTbr1CFezf2CCtip2CSatb2COtx1CBrn1/2CSox5CCoupTFICRorbȂǁjDƂ낪ĈȂŐ_oזEi_oOזEj̒iKɂĔ͂߂̂͂ꕔiBrn1/2CFezf2COtx1ȂǁjɂCق̓j[ɂȂĂ甭͂߂D̎́C_oזEi_oOזEjꎩ̂ԂɈˑIɕ\ωƂi<a href="#F3">}3a</a>jƂ͕KȂCȂƂCϋɓIɎx̂ł͂ȂDtɁCŏIIɕăj[Ƃĕ̂C邢́CړÎɃTu^Cv̌̉ߒ̏ȂƂꕔNĂ\zi<a href="#F3">}3b</a>jD
@֘AЂƂ̏dvȒmƂāCj[ƂĒaĂC̑܂łł΃Tu^CvlדIɓ]邱Ƃꂽ<a href="#R24"><sup>24,25)</sup></a>D̓Iɂ́C[w̃j[̕qłFezf2cɂĐw̃j[ɋƁC͐[w̃j[̃Tu^CvւƓ]Dc̃j[̃Tu^Cv̌ɂ邱̉Y̔́C]玿ɂw\̌`̉ߒ̗ɑ傫ȃCpNgD
@j[ȂƂcɂ̓Tu^Cv̌ɉYƂƂɂ͂ǂ̂悤ȈӋ`̂낤D̃qĝЂƂ́CӊOȎ瓾ꂽD̃j[̏WcgwhƂďW@\𖾂炩ɂ邱ƂړIƂāC̑wɓٓIɔזE\ʃ^pNTꂽʁCPcdh20ƂJhwX[p[t@~[ɑ^pNIVwɓٓIɁCCj[̈ړÎɔ邱Ƃoꂽ<a href="#R26"><sup>26)</sup></a>DŁC͑IVwɔzuׂj[IVwɏWߒ邱Ƃ҂Pcdh20jQƂC͂ɕU邾łȂCIIw/IIIwɈُɔzuꂽD͑IVw̃j[̃}[J[𔭌CIIw/IIIw̃j[̃}[J[𔭌D}[J[ł͂ȂC̓˗lזĚ`ԂȂǂIIw/IIIw̃j[ɓIȃTu^Cvɓ]Ă܂ĂĎʂłPcdh20̂̂Tu^Cv̌𒼐ڂɐ䂷\ےłȂCj[̈ړ̉ߒꎩ̂ɕKvȍזEiɊ֘A^pNjQȂǁCPcdh20Ƃ͖֌Wȕʂ̕̕@ɂC{͑IVwɔzuׂj[lדIɑIIw/IIIwɈُIɔzuɂĂCl̃Tu^Cv̓]邱ƂmFꂽDȏ̌ʂ́CIVw̃j[ƂĐ邽߂ɂ́Cj[IVwƂiזEOjɓK؂ɔzu邱Ƃ߂ďdvł邱Ƃ𕨌<a href="#R26"><sup>26)</sup></a>D
@{͑IVw̃j[Ƃĕׂj[𐳂邽߂ɕKvȁCIVwɓٓIȁiIIw/IIIwɂ݂͑IVwɂ̂ݑ݂ƂӖł́jזEO͉̎̂ł낤H@_ł͂܂qIȎ͕̂sł邪CIVwɐi鎲dvȖS\l<a href="#R26"><sup>26)</sup></a>DڍׂɂẮČɊ҂D
@ȏ̂悤ɁCj[̈ړ́Cj[K؂ȏɔzȗwɓٓIȍזEOɔI邱ƂɂC̃Tu^Cvւ̕𑣐i邽߂ɂdvȈӋ`Ƃ킩ĂD

<h2></h2>
@Mނ̔̔]ɂāCVYꂽj[͂Ȃړ̂H@Ƃɉɂ͂قǈړȂ邱ƂlƁCɂ͐_oH𕡎GĂŏdvȂȂ炩̐iIȈӋ`Ă\lDtɂȂCȂ]玿̐_oזEi_oOזEj͂̑啔]̋߂ɋǍ݂CזEiOזEĵ܂ܔ]̕\ʂɂނĒړĂȂ̂낤H@̑]玿̖͗삪B̐Ƃ̂ЂƂł邪CĈƂƊ֌W\z肳D]i]̂j]̕\ʂ̑ɂ̂݌`C]̑ɂ͌`ȂƂɂ֌W\D낢z܂ƁC{IɏdvȂƂ܂݂ĂȂCĂDX̃j[̋~N̖ڂŊώ@CVOiւ̔ǐՂėƂC܂ł̒ʏ̎@Ƃ͍{IɈقȂAv[`C̖{̗ɂ͕KvȂ̂ȂD

<h2> </h2>
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<li id="R11"><span class='au'>Sekine, K., Kubo, K. & Nakajima, K.</span>: <span class="ti">How does Reelin control neuronal migration and layer formation in the developing mammalian neocortex?</span> <span class='so'>Neurosci. Res., 86, 50-58 (2014)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/24969097" target="_blank">PubMed</a>]</span></li>
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<li id="R15"><span class='au'>Ajioka, I. & Nakajima, K.</span>: <span class="ti">Birth-date-dependent segregation of the mouse cerebral cortical neurons in reaggregation cultures.</span> <span class='so'>Eur. J. Neurosci., 22, 331-342 (2005)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16045486" target="_blank">PubMed</a>]</span></li>
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</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author"> ́iKazunori Nakajimaj</span>
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URLF<a href="http://plaza.umin.ac.jp/~Nakajima/" target="_blank">http://plaza.umin.ac.jp/~Nakajima/</a>
</div>
? 2017   Licensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
