C^[CL6ɂ_onƖƉun̗Z

<strong>LnNLE㐳W</strong>
iww@@\ Ɖuwj
emailF<a href="mailto:arima@molonc.med.osaka-u.ac.jp">LnNL</a>C<a href="mailto:murakami@molonc.med.osaka-u.ac.jp">㐳W</a>
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̈Zr[, <strong>1</strong>, e006 (2012)@<a href="http://dx.doi.org/10.7875/leading.author.1.e006">DOI: 10.7875/leading.author.1.e006</a>
Yasunobu Arima & Masaaki Murakami: <strong>Establishment of integrated field between neurology and immunology via IL-6 amplifier.</strong>

<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/10/Murakami-1.e006-PDF.pdf" target="_blank"><img class="size-full wp-image-112 alignright" title="Download PDF" src="/images/downloadPDF.png" alt="Download PDF" width="100" height="20" /></a>
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<h2>v </h2>
@a͋CCIɂ鎾̎ÂȂǁC×_onƖƉunƂ̊֗^͒mĂĂD܂ŁCS̐_o̊]̃z⎋ȂǂhCz̕Sg̖Ɖun𐧌䂷Cg-ƉunhɂĂ͂킵͂ĂDCS̐_o̊邢͕sړIɖƉu⎾̕WIɂ͂炫g_oVOinȟۂɊւẮC̖ѕq@\͂قƂǔĂȂDŋ߁CM҂܂߁C̃O[vɂC_oVOin̋̓IȎۂĂ̕q@\̉͂i݁CS̐_o̎hƖƉunƂZw╪̌`͂܂Dł́C͂߂ɖƉunƐ_on̊bЉCÂāC_o̊ɂƉua邢͖Ɖu̐ɂĂ̌ƉۑLqāCŌɁCM҂ɂCC^[CL6𒆐SƂȖƉǔǂ̂悤ɐ_oňƗẐD

<h2>͂߂ɁFƉunƐ_on̊b</h2>
@Ɖun̍זȆ͍זE琶܂ꂳ܂܂ȍזEɕDTזÊق̍זE͍ɂĐnCCTזE͋BɂĎȔ̏є񎩌Ȃւ̍œKȔlDƉunזE܂ꕪ鍜⋹BꎟƉuC񎩌Ȃ҂󂯊BCp߁CGCCpCGȂǂ񎟖ƉuƂDƉun͑傫2ɕނDiwIɌÂgRƉunhƁCrIVglƉunhłDRƉunɑזÉCזEC}Nt@[WCiDCD_CDC얞זEjCi`L[זEȂǂŁClƉun̍זEBזETזEłDỉߒɂĖƉun͑̓O̍׋ۂECX邽߂ɔB̂ŁCȂƔ񎩌ȂC邢́CF邱ƂłDRƉun̍זÉC׋ۂ̕\ʂ̃|C|^pNCږсCɁCECXɗRRNAC׋ۂECXDNAȂǁC񎩌Ȃ̂̃p^[ꂽ\CTollléiToll-like receptorFTLRjCRIGléiRIG-like receptorFRLRjCNODléiNOD-like receptorFNLRjȂǁCp^[Féipattern recognition receptorFPRRjɂFÐHDClƉun̍זÉCA~m_cЂƂ̈ႢC̕tЂƂ̈ႢC邢́C^pN̗̍\̈ႢFłCBזEêTזEêɂSĂDi`L[זEɂR̔F@\͏ŁCêƗ}ễVOĩoXɂ芈D
@lƉun̍זEƂĂ̑̓ɂ́CF̈`q̑gɂ`閳̑lBזEêTזEêꂼꔭBזETזE݂DECX׋ۂ̓ɐNƁCBזETזEɂĔ񎩌ȂFłêN[BDBזEê͔񎩌ȍR𒼐ڂɔFłC܂CR̗̍\FDCזE̓ɐNRC邢́C^pN̓̍\͔FłȂDTזEêMHCimajor histocompatibility complexCvgDK`q́jq̂ɒ񎦂ꂽ10`20A~m_cȂ񎩌ȃyv`hMHCqƂƂɔFDMHCqɂĔ񎩌ȃyv`ȟNoX̎͂ɂ͌lԂőlC̕ʂڐÂƂɈڐA҂TזEɂF邱ƂɂڐAЋ┽DMHCqɂ2ނCЂƂ̓L[TזEɍRyv`h񎦂MHCNXIqCЂƂ̓wp[TזEɍRyv`h񎦂MHCNXIIqłDMHCNXIq̓qgł4ނCׂĂ̗LjזEDMHCNXqɂRyv`h̒񎦂͍זEɑ݂邷ׂẴ^pNΏۂƂȂD܂CזEɂČÂȂtH[fBOɎs肵^pŃCrL`veI\[ɂĕ邱Ƃɂyv`hƂȂCMHCNXIqɂ񎦂D׋ۂECX͑B̂ŁCɊזEł͔񎩌ȂɗRyv`h͂MHCNXIqɂ񎦂DCqgł3ނMHCNXIIqɂCזE𒆐SƂR񎦍זEÐH񎩌ȂɗRyv`h񎦂DזE͂炾̋Xɂ܂ł܂Ȃ݂񎩌ȍR̐NɔƉuĎ̍ŏ̊֏łDŋ߂ł́CÐHꂽRMHCNXIqɂ񎦂NXv[e[VoꂽD́Ct@S\[񎩌Ȃ̃^pN邢̓yv`hזEɂłărL`CveI\[ɈˑɍRyv`hMHCNXIqɂ񎦂̂łD
@ECX׋ۂɂMHCNXIqɂR񎦂jQ^pN̂΂Α݂邱ƁC܂ĈזEłMHCNXIqȂ̂B邱ƂCMHCNXIqɂL[TזEւ̍R̒񎦋@\͊זE₪זEɂƂȋЂł邱Ƃ킩DCMHCNXIIqɂR̒񎦂wp[TזEƉunɂĂ͏dvłCƉǔזEłDۂɁC̍זEȂƁCȃL[TזE̔CBזER̂ʂɎY`זEւ̕NȂDwp[TזEق̍זEgwvhƂɏdvȃ^pNƂăTCgJCDTCgJCƂ́CזỄVOi`Bɏdvȉñ^pNŁCqʂ͖20,000ƔrICC^[CLiinterleukinFILjCC^[tFiinterferonFIFNjCPJCCBqCTNFitumor necrosis factorCᇉ󎀈qjCTGFitransforming growth factorCgXtH[~OBqjȂǁC100ވȏオ܂܂D܂ł̌C̃TCgJC͖Ɖun΂łȂC_onɂĂ@\邱Ƃ킩ĂD̃r[̎̂ЂƂłC^[CL6iIL-6j́CRƉunƊlƉun̗ɍpTCgJCłD
@wp[TזEł͍R񎦂ƂɎ͂ɑ݂TCgJCɂCꎩ̂̔TCgJC肳ĂD܂CIL-12IFNoTh1זEɁCIL-4IL-4oTh2זEɁCIL-6TGFIL-17oTh17זEɁCTGFƂقTזE̊}鐧䐫TזEiT<sub>reg</sub>זEjɕD̃wp[TזẼTuZbĝȂŁCƂɎȖƉu≊ǂɑ΂Ɋ֘ÂTh1זETh17זEłCAM[ȂǂɊ֘ÂTh2זEłDM҂炪ΏۂƂĂ鎩ȖƉûȂɂ́CTזEȂ̍RFĉǂ邱Ƃɂ葟̋@\QĔǂ̂DM҂炪C_onƖƉunƂ̑ݍpؖdǂ̃fłIȖƉu]Ґ́C~GISfhTCg^pNɗRyv`h}EXɖƉu邱ƂɂC_onTh1זETh17זEɈˑǂÛłD
@̃r[̂ЂƂ̎ł_ońCꂪ邽߂̔sɕKvȏ炾̋Xɂ܂œ`BsÅ튯łD_onƖƉunł͋@\^pNLĂ邱ƂXmĂDƂ΁C}EXTזE̕\ʂɑ݂Thy1R͐_õ}[J[ƂĂLłDɁC_on̔̍ۂɋ@\KC_X^pNłZ}tH͂܂܂ȖƉuזEɔĂCƉuɐ邽߂ɂɏdvłD܂CM҂炪ΏۂƂĂIL-6t@~[TCgJCɂ́C_oזẺh{qłCNTFiciliary neurotrophic factorC@їl_oh{qjĂD
@_on͔]i]CԔ]C]CC]CjƐҐȂC_on疖ɂނт̂_onłD]̂ȂłCƂɐ̈ێɏdvȊԔ]C]CC킹Ĕ]ƂDC_on͐_oזÊW܂Đ_o߂`C_oہijɂĒ_onƊȇƂłD]ł閖_o͔]_oƂCk_oC_oC_oCԐ_oCO_oCO]_oCʐ_oC_oC_oC_oC_oC㉺_o̍E12΂݂DCҒŐ_o͐Ғł̒ŊԌƂ1΂݂Dł8΁iC1`C8C}EXł7΁jCł12΁iT1`T12C}EXł13΁jCł5΁iL1`L5C}EXł6΁jCł5΁iS1`S5jD_oɂ͖̑킩璆_onɃVOi`B鋁S_oƁC_oñVOi𖖏̑ɓ`B鉓S_o2ނ݂Cwp[TזEƓlɁC}̐_oƋ̐_o݂D
@@\Iɂ͐_on͑̐_oƎ_oƂɑʂD̐_óCO̎h`B鋁S̊o_oƁCɂĔNS̉^_oȂDC_o͐SCCċzCȂǂ炾̍P퐫Ɋ֗^̂ŁCⓦ̂Ƃɋ@\_oƁCx̂Ƃɋ@\镛_oD̂̂̑ɕz鋁S̊o_o͌㍪_o߂oRĐҒł̔w̌㍪ɓ蒆_onɂȂD_on̉S_o͐Ғł̑̕O͉^_oƂĖ̑ɂȂDo_oƉ^_o̐_oۂ͌㍪_o߂ƌ_oƂƂɂЂƂɂ܂Ƃ܂薖̑ɕzD̐_oƂďdvȂ͓̂̊o_oщ^_oł_oŁC]_o12΂̂ȂŗBCɂ܂ŒBĂD

<h2>1D_on̊ɂƉuaіƉu̐</h2>
@_onɂ邳܂܂Ȏ̕aԂ̌`ɂāC_onɑ݂}Nt@[Wl̍זEł~NOA͂ƂCz錌tNƉun̍זE̊֗^񍐂͑D_onɂ鎩ȖƉuł鑽dǂ̂قɂC_oϐɕނAcnC}[aCp[L\aCҍdǂȂǂ̕aɂāCTזȄWςIL-17ǍZx̏㏸񍐂Ă<a href="#R1"><sup>1-3)</sup></a>DɁCҒł𑹏ہC̕aɐZ銈TזECƂTh1זEU邱Ƃꂽ<a href="#R4"><sup>4)</sup></a>DǂȂǂ̐_ɂĂCǂ̕aԂɊ֗^Ă邱ƂĂD
@ɏqׂ悤ɁC_oւ̎hɂ͋SƉS2݂C_onƖƉunƂ̑ݍp͂ꂼ̐_oւ̎hɂ鐧ĂDÂF߂ꌤ̐ił_o-ƉuݍṕCS̐_o̊≺-tnɍpCXeCh\ƂR`RChAhiȂǃJeR[A~ɕoCnƉunɊԐړIɉegS_o--Ɖun̑ݍphł<a href="#R5"><sup>5-7)</sup></a>DۂɁC_oւ̎hɂORR`RChƉu̗}@\̘_͑XDƂɁCBɑ݂cTזE̓ORR`RChɑ΂Ɋ󐫂C܂܂Ȑ_o̊ɂeD܂C܂܂ȉǐɐ閝uɂɂẮCS̊o_o̎h₦ԂȂ͂邱ƂɂC̎h𓊉e]̊Ď`ԂǂɈˑIɕω邱Ƃ킩ĂD
@CS̐_o̊BCCB⃊p߂Ȃǂ̖ƉuɒڂɍpC_o`B^pN̕ړIɖƉuזEߖT̍זEɉegS_o-Ɖun̑ݍpȟɂẮCfIȌ_炷悤Ș_͂قƂǂȂD̃̕pCIjÂЂƂ́CčTraceymłDނ̃O[v́Cł1990Ň㔼炱̌̕sĂDCS̖_oւ̎hMORR`RCh̕U邱ƁCS̖_oւ̎hjR`êB̃p邱Ƃ킩ĂDɁCՏIȒmCi҂ɂjR`̐ێ悪LӂɉP邱ƂoꂽD̔wiCނ̃O[v́CAZ`R쓮̕_oǔ}Ƃ̉ĎʁC_ỏS̊ɂhAZ`R}Nt@[W̊}Ă邱Ƃo<a href="#R8"><sup>8)</sup></a>D̓Iɂ́C<em>in vitro</em>ɂɂāCGhgLV̎ĥ̂}Nt@[W甭鉊ǐTCgJCCTNFCIL-1CIL-6CIL-18̔̓AZ`Rɂ}ꂽCǗ}TCgJCłIL-10͉̔eȂDtɁC_o̓dChɂ銈IL-10ƃORR`RCȟZx̏㏸UDނ́C̉S_o-Ɖun̑ݍpAZ`R쓮̍RǌoHƍlCȂ錟킦ĎʁC_ỏS̎hɂCǐ_o߂ւB_o̖[BɂămAhi̔U邱ƁC̃mAhi̓[\^CD4zTזEɂăAhi1êƃAhi2êɍpăAZ`R̔U邱ƁCɂ̂̂CAZ`R͋ߖT̃}Nt@[Wɂă7jR`AZ`Rêɍpă|ɂĥ̂TNF̔}邱ƁCo<a href="#R9"><sup>9)</sup></a>Dނ͌݁CƉuւ̐_o`B̕oɂƉuזE̗}oHgInflammatory ReflexhƂсC𑱂Ăi<a href="#F1">}1</a>jD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@Ɖuւ̐_o`B̕oɂƉuזE̗}oHgInflammatory Reflexh</strong>
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@CM҂炪Vɔ_o-Ɖun̑ݍṕCS̊o_o̊Š_o̊ЂNC5ł̔w̌ǂ̓זEɃPJC̉ߏ蔭̋@\łgIL-6AvhmAhiɈˑIɊCPJCCCL20U邱Ƃɂ茌̎ȖƉuTh17זE̕ʂɏWςȖƉuÛł<a href="#R10"><sup>10)</sup></a>i<a href="http://first.lifesciencedb.jp/archives/4397" target="_blank">V_r[</a> łfځjDŋ߂ɂȂČǓזEւ̋ǏIȐ_oւ̎hɂƉȗioH́gGateway ReflexhƖÂꂽ̂ŁCM҂̖̂pi<a href="#F2">}2</a>jD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@ǓזEւ̋ǏIȐ_oւ̎hɂƉȗioHgGataway Reflexh</strong>
d͂ɂq؂̊͊o_ohC5łւ̌_o̊UD_o̖[̓mAhioC5ł̔w̌ǂ̌ǓזEɂIL-6AvߏɊD̈A̎hC5ł̔w̌ǓזEɉߏ̃PJCCCL20UƉuזEЂ悹DtɎ̌ƂȂ悤ȕaTזE݂ƁC]ѐҐɂĎȖƉuЂND
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/10/Murakami-1.e006-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2012/10/Murakami-1.e006-Fig.2.png&amp;caption=fig2-caption-text]

@ɁC_o̊gDւ̍זE̐Z𑣐iĂ邱ƂɂĂ͕M҂̂قɂ񍐂CT[JfBAYɂ_o͔̊ƉungDɂăAhiêPJCڒq̔㏸CgDւ̖ƉuזËڍs𑣐i邱ƂɂsǐVbNɂ^Ă<a href="#R11"><sup>11)</sup></a>D܂CƉułȂ̌ɂĂC_oւ̎h̎Ɋ֘AƂ񍐂ȂĂC}EX̎ɂCLԂɂĂ܂܂Ȍ`̂̕zuĎ炷邱ƂɂCזȆ}łƂD̗}@\̋@ƂāC܂܂Ȏohɂ_o̊NC̉Ńv`̔}ᇂ̗}ɂȂƂ̂Ƃؖꂽ<a href="#R12"><sup>12)</sup></a>D
@̂悤ɁC_o邢͕_onƉuזEɒڂɍpCƉunזEԐړIɍp肷邱ƂɂCŏIIɖƉu𐧌䂷邱ƂXɖ炩ɂȂDȉCM҂IL-6Av̔܂ގȖƉǔ̊TvЉĈ̂CGateway Reflexɂċ̓IɏЉD

<h2>2D@\TCgJCIL-6̔Ƃ̎ê̍\</h2>
@1981NCrv́Cj҂̔xEZoזE̔|{㐴ɑ݂BזEɁCR̂̎YUn̕q邱Ƃ𔭌<a href="#R13"><sup>13)</sup></a>D̃C^[CL6iIL-6j́C1986Nɂ́C`q̍\肳ꂽ<a href="#R14"><sup>14)</sup></a>D̂̂̈`qg^pNpCIL-6ɂ͑ʂȋ@\̂邱Ƃ킩DƂ΁C̑ɂĂ͂炫ǂ̎wWƂȂ}̃^pNYC`זȆBqƂȂCJ|W̑BqƂȂCTMEזȆBqƂȂCYC̐_oɂĎCɂ͂炫ẽz𕪔傳CjזECP`mTCg𑝐BCTזE̐UCȂǂł<a href="#R15"><sup>15)</sup></a>DCIL-6YזE͔ɑC̍זE͊IL-6YD
@1988Nɓ肳ꂽIL-6ếCזEÖɃTCgJCẽt@~[ɓI4̃VXeCchCCɁCTrp-Ser-Cӂ̃A~m_c-Trp-SeriWSxWSjƂ`[tĂDCזË͋ɒ[ɒZ߁CIL-6êɉVOi`B^pN݂̑ꂽDۂɁCIL-6IL-6êɂ͕q130,000̓^pNgp130<a href="#R16"><sup>16)</sup></a>Dqg̑ٔՂgp130𐸐čRgp130R̂쐻邱ƂɂCgp130R[hcDNAN[jOꂽ<a href="#R17"><sup>17)</sup></a>Dgp130IL-6IL-6ê̎hɂʑ̂`CזE̋ߖTɂ`VLi[[JAKƌ邱ƂōזEɃVOi`B<a href="#R18"><sup>18,19)</sup></a>D̂̂CSTAT3JAK̊ɈˑIɊēʑ̂`CjɈړĉǐ^pNR[h`q̓]ʂ𘴐iD̂ƂCIL-6VOĩ̕tB[hobNɋ@\SOCS3CSOCS3gp130ɌJAK̊}邱ƂɂIL-6VOi͎<a href="#R15"><sup>15)</sup></a>i<a href="#F3">}3</a>jD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@IL-6VOi`BoH</strong>
gp130IL-6̌IL-6êɂʑ̉C`VLi[[łJAKɌ邱ƂōזEɃVOi`BDJAK̊ɂ胊_ꂽgp130C[4̃`VcCY767CY814CY905CY915ɂSTAT3CSTAT3JAKɂ肳Ƀ_ēʑ̉jւƈړDSTAT3̕WI^pNłSOCS3́CJAKɂ胊_ꂽgp130̃`VcY759JAKɌCJAK̊}邱ƂɂSTAT3̊D
PF_D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/10/Murakami-1.e006-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2012/10/Murakami-1.e006-Fig.3.png&amp;caption=fig3-caption-text]


<h2>3DIL-6Ɉˑ̃E}`f}EXIL-6Av̔</h2>
@RIL-6e̍R̂ɂ薝֐߃E}`ւ̑傫ȎÌʂꂽ<a href="#R20"><sup>20)</sup></a>DȂČʂ̕q@\͒Nɂ킽słD̗R̂ЂƂ́CIL-6ˑ̂悢f݂Ȃ߂łDM҂́Cgp130ɂāCSOCS3Ƃ̌ɏdvTyr759PheɒumbNC}EXCF759}EX쐻<a href="#R21"><sup>21)</sup></a>D̈`qσ}EXłSOCS3Ɉˑ̃̕tB[hobN@\}IL-6VOiIɓ邱ƂɂC1NقǂŃE}`l̊֐߉ǂ<a href="#R22"><sup>22)</sup></a>DF759}EXMHCNXIIq邢CD4}EXƊ|킹Ǝ̔ǂ͗}C܂CF759}EXł͊CD4zTזEƂƂɑDɁCF759}EXpڐA̎CƉunזEɉߏIL-6VOi݂ƁCCD4zTזE̔ǂ邱Ƃ킩<a href="#R23"><sup>23)</sup></a>DɎi߂ƁCߏIL-6VOi͐ۉזE⌌ǓזEȂǔƉunI^R[QzזEɍpTזE̐UTCgJCIL-7̔UCCD4zTזECƂTh17זE֐߉̗U邱Ƃ炩ɂȂ<a href="#R23"><sup>23,24)</sup></a>D܂CF759}EX̊֐߉́CƉunזEɉߏIL-6VOi`BIL-7邱ƂŁCԐړITh17זEU邱ƂɂЂNĂD
@̋^́CߏIL-17͂ǂ̂悤ɃE}`l֐߉U邩łDIL-17̂Cɂď㏸TCgJC𒲂ׂD30ȏ̃TCgJCуPJCɂĒׂCIL-6ƃPJĈ݂ɑʂɗUꂽD̎_@ƂāCIL-6݂̑̂IL-17I^R[QzזEɍpIL-6ĂёʂɔIL-6̐̃tB[hobN@\CgIL-6Avhꂽ<a href="#R24"><sup>24)</sup></a>i<a href="#F4">}4</a>jD̂̌CIL-6Av͋@\Iɂ̓PJC̑ʔǏɂ鉊ǂU@\łCqwIɂNF-BSTAT3̓ł邱ƁCɁCaIɂ͎ȖƉu܂މǂ̗Uɏdvł邱Ƃؖꂽ<a href="#R24"><sup>24-26)</sup></a>D

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@ǐPJC̔U@\gIL-6Avh</strong>
ۉזECǓזEȂǂI^R[Qz̔ƉunזEIL-17AIL-6͂炫NF-BSTAT3ƁCPJCȂǉǗU^pN̔𑊏IɗU@\gIL-6AvhDIL-6Av̊ɈˑIɁCF759}EX̊֐߉͂ƂCdǂ̃fłIȖƉu]ҐǂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/10/Murakami-1.e006-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2012/10/Murakami-1.e006-Fig.4.png&amp;caption=fig4-caption-text]


<h2>4Dt]֖Ƒd</h2>
@_on͌t]֖Ƃ΂ȋ@\ɂʂ̑Ƃ͊u₳ĂD݂̑1913NɎ؂ĈȗCȌǂ̍\̂ł邱ƂĂD̂ɁCdqɂώ@ɂC_oňǓזÊɂ͖i^CgWNVj݂̑邱Ƃ킩DɁC猌ǂƂ܂זEזECAXgTCgC}Nt@[WȂǕɂ킽邽߁Cɑ݂זĚǂ̊Oւ̐ZĂD́Cɑ݂זE╪qʂ̑傫ȕ͌t]֖ʉ߂łȂƍlĂCŋ߂ł́C܂܂ȃgX|[^[̌ǓזEɑ݂ĂCq̑IIȏô邱ƂؖꂽDȂC_onɂĂ]ᇂȂǂ͔ǂCɁCECX̊⎩ȖƉuDۂɁCȒ_onɂÐHp~NOA݂C܂܂ȖƉunזEʂł͂邪݂ĂDƉunǂ̂悤ȋ@\ɂ茌t]֖ʂC_onɂĔ񎩌ȂĎr̂͒N̋^łDȂǂɂ͌t]֖݂͑ȂƂƉuזE͂̂悤ȕʂ璆_onւƈڍs\C邢́Ct𕪔傷]̖paTזE̐N\ĂD
@M҂炪E}`ƂƂɌΏۂƂĂ鑽dǂ́C_on̒EłC]CҐC_oȂǂɑlȐ_oǏ󂪐C̊҂ł͍ĔƊԂD莾ɔF肳ĂwałC킪ł10l10lقǁCĂł10l50lقǂ̜늳łDɑǂ̃s[N30΂قǂłD͊Sɂ͓肳ĂȂCȔCD4zTזECƂTh17זETh1זE̊֗^ĂD̂悤ȑdǂ̓fƂāCM҂́CIȖƉu]ҐpĂDȍRł~GISfhTCg^pNyv`h𐳏C57BL/6}EXɖƉuƁC2TԂقǂŐҐє]ɎȔCD4zTזEiTh17זETh1זEjZჂ咥ƂaԂ悷DaԂ𔭏ǂ}EX玩ȔCD4zTזEPĐȃ}EX̐ÖɈړ1TԂقǂŎアǏ󂪔F߂C2TԂs[NɎIȖƉu]Ґ̕aԂ𐶂DǓזEƉunזEɂgp130STAT3}EXhɂƂ̕aԂ͗}C܂CIL-17AmbNAEg}EX玩ȔCD4zTזE쐻ƂɂaԂ͗}ꂽƂCIȖƉu]Ґ̔ǂIL-6Av̊ɈˑĂ邱Ƃ킩<a href="#R24"><sup>24)</sup></a>D

<h2>5DȔCD4zTזĚt]֖ɂN</h2>
@M҂̍쐻IȖƉu]Ґ̕aԂ̔ǂ́CȏIɂ͔ɕsvcȂ̂łDt]֖݂̑ɂ炸Cɑ݂鎩Ȕwp[TזE_onɐNaԂ`̂łDaԂ̖mȔǂ܂CȔwp[TזE̐Öւ̈ړ̂̂5ڂɂĐҐώ@ƁCȔwp[TזE͑5ł̔w̌ǂ̎͂ɂ݂̂ɏWςĂi<a href="#F5">}5</a>jD̏WςI^R[Qz̔ƉunזE⌌ǓזEɂgp130邢STAT3ƔF߂ꂸCɁCȔwp[TזEIL-17AƂɂF߂ȂƁC̕ʂ̌ǓזEɂSTAT3NF-BĂƂCǓזEɂIL-6Av̊Ȕwp[TזȆ5Ŕw̌ǂ̎͂ւ̏Wςɏdvł邱ƂؖꂽDIL-6Av͂܂܂ȃPJC̗U@\łĎnɂďdvȃPJC݂̓ƂC5Ŕw̌ǂłTh17זȄWςɏdvȃPJCłCCL20̔㏸ĂC܂CCCL20êłCCR6鎩Ȕwp[TזEł͂̐Z͗}ꂽD

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@IȖƉu]Ґ̔ǏɂĕaCD4zTזE͑5ł̔w̌ǂ̎͂ɏWς</strong>
IȖƉu]Ґ𔭏ǂ}EXɕaCD4zTזEړ̂5ڂɁCҒłɂĐؕЂ쐻זȄWς͂D
iajw}gLV-GIVF5ŁD
ibjF̎lp̕g債摜D
icjw}gLV-GIVF5ł̐ؕ10pč\zO摜DF̋CD4zTזECԐF̃`[u5łɂ錌ǂDaCD4zTזE͑5ł̔w̌ǂɑWςĂC5ł͌t]֖ɂNɂȂĂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/10/Murakami-1.e006-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2012/10/Murakami-1.e006-Fig.5.png&amp;caption=fig5-caption-text]

@ȂC5Ŕw̌ǂɂIL-6AvߏɊCCL20Ă̂낤H@5łɂ͍ő̍Rd͋؂łq؂̊o_ǒ㍪_o߂݂̂ŁCd͂̎hɂƂȂq؂̊o_o̊֗^ĂƉ肵DŁCčqFǌǁiNASAjɂĊJꂽnŖd͂Čłng㎈hpi<a href="#F6">}6</a>jD㎈𖳏d͏ԂɂƑ5Ŕw̌ǂɂCCL20̔͒ቺCȔwp[TזȄWς͔F߂ȂȂD̂ƂC㍪_o߂ł͊o_o̊F߂ȂDɁC̏ԂŃq؂dChƁi<a href="#F6">}6</a>jCh̎ԂɔႵđ5Ŕw̌ǂɂCCL20̔ƌ㍪_o߂ɂc-<em>fos</em>`q̔񕜂DɁCrO؂ڎl؂dChƁCꂼ̊o_ǒ㍪_o߂݂̑ł3Ŕw̌ǂɂCCL20̔ƌ㍪_o߂ɂc-<em>fos</em>`q̔㏸ƂCo_ỏߏȊɂ肻̌㍪_o߂݂̑镔ʂ̋ߖTCҒł̔w̌ǂɂăPJCCȔwp[TזE̒_onւ̐N`Ă邱Ƃ킩D

<a name="F6"></a><div id="fig6-caption-text" style="display: none;"><strong>}6@nŖd͂Čłng㎈h</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/10/Murakami-1.e006-Fig.6.jpg" target="_blank">[Download]</a></div>[hs_figure id=6&amp;image=/wordpress/wp-content/uploads/2012/10/Murakami-1.e006-Fig.6.png&amp;caption=fig6-caption-text]

@̋^́Co_ỏߏȊǂ̂悤ɑ5Ŕw̌ǂ̏Ԃω邩łDǂ̏Ԃ͈ʓIɁC_oł_oƕ_oɂ萧䂳ĂD5Ŕw̌ǂɂ錌̑x𑪒肵ƂC㎈ɂ肻̑xLӂɌCɁCq؂̓dChɂ肻̑x͉񕜂D5ł̋ߖŤ_o߂łc-<em>fos</em>`q̔ߏłC̏Ԃ͑1łɔrLӂɍDۂɌ_o̖[番傳mAhiɂ茌ǓזEƁCIL-6Av̊͘iDɁCmAhiê̑jQŏƁC5ł̔w̌ǂɂCCL20̔CNF-B̊CȔwp[TזE̐ZCɁCaԂ̔ǂLӂɗ}ꂽDȏ̎Co_ỏߏȊ͋ߖŤ_o߂̊ЂNƂ炩ɂȂD̂ƂC_oɂxz̈̌ǓזE͉ߏȃmAhiɂ蔘ICIL-6Av̉ߏȊCCL20ĎȔwp[TזE̐N`C̕ʂ璆_on̉ǐU<a href="#R10"><sup>10)</sup></a>i<a href="#F2">}2</a>jD
@̌ʂ瓾ꂽC_onƖƉunƂ̑ݍpɊ֗^VRZvǵCߏȐ_oւ̎h͋ߖŤǂ̏ԂωƉuזE̐ZɊ֗^CƂ̂łDCׂꂽ_oւ̎h͏d͂⎋oN_Ƃ̂łC_IȎh܂ނق̎hłCl̎ۂ_on܂߂܂܂ȑ̌ǂɐ\D̂߁Cɉ^葟ɑ΂鎩ȔTזE݂C̑̋ߖTɐ_oւ̉ߏȎh݂ƁCǂ̏ԂωĕWIւ̎ȔTזE̐ZǂЂN\C̃RZvǵCɓٓIȎȖƉu̔ǋ@\ɐVȎ_𓊂̂ƂD

<h2></h2>
@E}`fpIL-6Av̌CIL-6ǂUɂ͔ƉunI^R[QzזẼPJC̉ߏȔdvł邱Ƃ킩DɁCIL-6Av͑dǃfɂďd͂ɂ_oւ̎hƂ܂āCt]֖ɂƉuזE̐Ň`ɖ𗧂ĂDIL-6AvƂRZvǵCCD4zTזEȂǂ甭TCgJCƉunזEɂ͂炭NF-BSTAT3ɊCߏȃPJC̎YċǏɂ鉊ǂUƂ̂ŁCM҂́C̋@\ǁCƂɖǂ̍{ƂȂ錴ƍlĂDۂɁCIL-6Av̐`qWI`qɊւC`wIȎ֘A`qƂ̔rsĂ݂ƁCɂ͎ѕaԂ̊֘A`qX܂܂C܂C̎ѕaԂȖƉu΂łȂC^{bNǌQC_oϐĈق̉ǐɂ܂łłDCIL-6Av̂Ȃ͂ɂCǂN_Ƃ鎾ѕaԂ̔ǋ@\ƂɂCǂ̊֗^邳܂܂Ȏɂꂵސlɏłvł΂ƍlĂD

<h2> </h2>
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</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">Ln NLiYasunobu Arimaj</span>
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<strong> WiMasaaki Murakamij</strong>
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URLF<a href="http://www.med.osaka-u.ac.jp/pub/molonc/www/index.html" target="_blank">http://www.med.osaka-u.ac.jp/pub/molonc/www/index.html</a>
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