vOזEF̕q@Ɣɂ鐶IȖ

<strong>OY K</strong>
iww@wn `wj
emailF<a href="mailto:miura@mol.f.u-tokyo.ac.jp">OYK</a>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
̈Zr[, <strong>1</strong>, e002 (2012)@<a href=" http://dx.doi.org/10.7875/leading.author.1.e002">DOI: 10.7875/leading.author.1.e002</a>
Masayuki Miura: <strong>Molecular mechanisms and physiological functions of programmed cell death during development.</strong>

<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/09/Miura-1.e002-PDF.pdf" target="_blank"><img class="size-full wp-image-112 alignright" title="Download PDF" src="/images/downloadPDF.png" alt="Download PDF" width="100" height="20" /></a>
<p>
<p>
<p>
<p>
<p>
<!--more-->

<h2>v </h2>
@󐸂甭̐iނȂCזEłۂmĂDCƂVȂ̂ĂvZXɂāCꂽ̂킴킴菜ĂƂCCނƂv錻ۂs𓾂܂łɂ͎ԂD20IĈ݂Ă匤O[v̗Uۂ𔭌SpemannłC̈h́CVזE𔭓WIɐݏoẴvZXɍזE܂܂邱ƂC͂߂͎󂯓Ȃ悤łDĈ̐_oזĚזE̐ɕKvȐ_oh{q݂̑炩ɂȂCɁCp`wIȌA|g[VẌ`wIȐ@\炩ɂȂDāCA|g[VX`wIɑ삷邱Ƃł悤ɂȂƂŁCזE̐̂ɂ@\₤\ɂȂĂDł́CA|g[VX𒆐SƂvOזE̔ɂ鐶̋@\ɂĉD

<h2>͂߂ɁFɂזÊ͂܂</h2>
@Hamburgeȓɂ<a href="#R1"><sup>1)</sup></a>CɂčזEӎČŝ̓hCcHeidelbergwKalliushŏŁĈȂɂ́CꂽErnstGl?cksmannDGl?cksmann1930N1951N̑ɂāCҒœ̔ɂזE̖@\ʂȉ3ɂ܂Ƃ߂Ă<a href="#R2"><sup>2)</sup></a>D1j`Ԍ`ɂזEFɂדcoƂזE^ɂƂȂċNזEC2jgD`ɂזEFgD튯̌`ɂĕזEłĂߒɂ݂זEC3jnɂזEFiIɏʂȐł͔̂Ƃɂ艺ʂ̐ɑ݂\ߐɏôɎD`Ԍ`ɂזE͏̕ό`ZɂčLĂɊώ@C_oǂ̕邢͊⎨̌`̍ۂ̍זEƂĂĂDgD`ɂזE̖_Ăӏł͋[l@ȂĂD񂾍זEo郊{j_܂̍זEɂȂ炩̗UIȍp炷̂ł͂ȂƂ̂łDזEsvȍזȄƂɓIȐۂł邱ƂC̐isɐϋɓIɂ邱Ƃc_Ă_ŒڂD̍ĺCSpemannh́Ĉ݂A̗UIȌۂ̘Aɂʊ֌WɂƂ߂lɗގĂD
@Gl?cksmann̑ɂ݂悤ɁC挩̂l͂CɂזE̓A|g[VX̌`ԂƂÂȍזEłC܂ɉe邱ƂȂsvȍזEƂď̂ƈʂɂ͗ĂDĈɏqׂ悤ɁCߔNCVEWEoGɂ㏞B̎qhɂĐ̎CA|g[VXNזE͂܂ɐϋɓIɑBqočזȆB𑣂Ƃ炩ɂꂽD
@ҒœɂẮC`Ԍ`ɕKvȃtHQ𕪔傷gD̈ꕔ΂΍זEɂ莸ĂƂώ@ĂDƂ΁C`ۂFGF𕪔傷OtCɉShh𕪔傷ɐт́C`Ԍ`ɕKvȃVOi𕪔傷VOiZ^[ƂĂ̖C̗̈̓VOi𔭂Ƃ͍זEɂ莸Ăi<a href="#F1">}1</a>jD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@זÊ锭</strong>
זE͕svȍזȄ̂قC܂̍זE֐ϋɓIɂ͂炫邱Ƃɂ蔭Đ𐧌䂵ĂD
iaj`̂Ƃ̃VOiZ^[ɂA|g[VXD
ibjA|g[VXNזËqɂ܂̍זEւ̉eDvX^OWE<sub>2</sub>͂܂̍זȆB𑣐iDɂזEoATP̓}Nt@[WUD
icjA|g[VXNזEɂ܂̍זEւ̒͂̔D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/08/Miura-1.e002-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2012/08/Miura-1.e002-Fig.1.png&amp;caption=fig1-caption-text]


<h2>1DvOזE̕q@\̒T</h2>
@1900N㒆CSpemannh̔w҂́CCCāCU𔭐vZX̊{ƍlĂD䂦ɁCɂčזEɂ萶錻ۂώ@ĂCɑ΂قȂ߂ĂD܂C̓r̐Ґ̒mo_o߂^_ojɂזĚ́CזEKvƂ镔ʂւƈړƂɂƂ̉߂łDۂώ@CSpemannwh̉eȂC^A̐_oȊwLevi-Montalcinỉ߂͈قȂDזĚ͐_oזEɂƍl̂łD̂̂CLevi-MontalciniHamburgeřC_o̎xzWIgD̉eɂ_o͈̐ێĂƂ̃RZvgoꂽDāC_oh{qinerve growth factorFNGFjC_oזE͂̐@\ƂƂɒڂ悤ɂȂD1972NCKerrCWyllieCCurriéC܂܂ȑgD̊ώ@CזEɂ2̃^CvƂDA|g[VXiapoptosisjƃlN[VXinecrosisjłDA|g[VX̓MVŗtӖ錾tłDKerr炪C܂܂ȑgD̍זEĂ˂Ɋώ@̌`ԂɋʂȐƂCA|g[VXƂ̂TOӖ͑傫<a href="#R3"><sup>3)</sup></a>D1992NCRaff́CׂĂ̍זE͂̐זEЉɈˑĂƂ̑Cq̍p̈ʐD
@_oזENGFɂ萧\łƂĈ݂Ɋւ錤|{_oזEpčsꂽD1988NCJohnsońCNGF̏ɂ_o̍זÉCRNA^pN̊ȐKvƂ錻ۂłƔ\<a href="#R4"><sup>4)</sup></a>DA|g[VX`q̐邱Ƃ錋ʂłDāCA|g[VẌ`IȐɊւ蒼ړIȌCpčsꂽD

<h2>2DvOזE̕q@\̔</h2>
@NGF̏ɂ_oזEɈ`q̔KvȂƂ͎IɎꂽCvOזE̎sɂ`IȐɂẮCFڌ̂ȂԂłD̏󋵂ɏI~̂́Cpq`wIȌłD<em>Caenorhabditis elegans</em>͑̂Ŕώ@₷C󐸗̍זEnׂĖ炩ɂĂB̑זEłD̂炾Âł́CK܂זEn1090̍זE܂131̍זEłD܂ɁC`IɃvOꂽזEɂĎsĂ킯łD
@̍זEɒڂ1980Nォ͂܂DHedgecocḱCזẼvZXɈُ͂߂Ă̕ψّ́C<em>ced-1</em>ψّ̂<em>ced-2</em>ψّ́i<em>ced</em>F<em>cell death abnormal</em>j𔭕\CזE`Iɐ䂳Ă邱ƂD̂Ƃꂽψّ̂́CזE̎sł͂ȂC񂾍זEÐHɉêłD̍זẼvZXώ@ƁCʂׂזE܂ĎÐH܂2ԂȂ̂ŁC炾̈قȂꏊŎUIɋNזȆŜώ@̂͂ނDC<em>ced-1</em>ψّ̂<em>ced-2</em>ψّ̂ł͎זEÐHꂸ̂Ɏc邽߁CߋɍזE̋NƂm̂eՂɂȂ̂łDÂāCHorvitžɂāC<em>ced-1</em>ψّ̂pזE̎sȂψّ́i܂CזE̎[̏oĂȂψّ́j̃XN[jOsCIȕψّ<em>ced-3</em>ꂽ<a href="#R5"><sup>5)</sup></a>D<em>egl-1</em>ψّ̂ł͉AɂYɕKvȋؓxz_oזENĎ邽ߎYłȂȂD<em>egl-1</em>ψّ̂<em>ced-3</em>ψّ̂Ƃ̓dψّ̂́CזE}邽ߎYsS̕\^񕜂D<em>egl-1</em>ψّ̂̕\^͊ώ@₷C<em>ced-3</em>`q̑Η`q𓯒肷XN[jOɍDsłD<em>egl-1</em>ψّ̂Ƃ̓dψقɂY\ɂȂψّ̂XN[jO邱ƂɂC<em>ced-3</em>`q̑Η`qꂽقCVK̈`q<em>ced-4</em>肳ꂽ<a href="#R5"><sup>5)</sup></a>DĂɁCזE̐ɂ@\l^̕ψّ̂Ƃ<em>ced-9</em>ψّ̂ꂽ<a href="#R6"><sup>6)</sup></a>D
@̂̂Cꂼ̕ψّ̂̌`qN[jOƁĈׂĂMނɂĂۑꂽ`qłCA|g[VX̐̒SƂȂ^pN̈ÃXN[jOɂ蓯肳ꂽDCed-3̓^pNyf̂ЂƂJXp[[CCed-4͂̊^pNApaf-1CCed-9Ced-4̊jQBcl-2t@~[^pNCEgl-1Bcl-2t@~[^pN̂͂炫}^pNBH3 only proteinR[hĂD2002NC`ẘb\zBrennerC̍זEn𖾂炩ɂSulstonCɂזĚoH𖾂炩ɂHorvitz3ɁCm[xww܂^ꂽD

<h2>3DA|g[VX̎sɕK{łJXp[[̊̋@\</h2>
@ł̓vOזEɕKvȃJXp[[Ced-3݂̂ł̂ɑ΂CVEWEoGMނł͕̃JXp[[זEɂĂDׂẴJXp[[͊̂قƂǂȂÔƂĐDN[vhCCp20Cp10ɕ邪CJXp[[̓vhC̍\Ɗ̓Tu^CvɕނDvhC̓^pNԂ̑ݍpSCARD邢DED\ĂāCזE̎hɈˑĂCARD邢DEDɂق̃A_v^[^pN邱ƂɂJXp[[͑ʑ̂ƂȂ芈D̃^CṽJXp[[̓CjVG[^[JXp[[Ƃ΂C̊JXp[[JXP[h̊JnVOiƂȂDZvhCJXp[[3CJXp[[6CJXp[[7́C㗬̃CjVG[^[JXp[[ɂp20p10ɐؒfċ悤ɂȂDGtFN^[JXp[[ƁC܂܂ȊؒfčזEsD݂܂łɁC1000ȏ̃GtFN^[JXp[[̊oĂDCjVG[^[JXp[[ɕނJXp[[8̊ƂĂBH3 only proteinłBidmC̐ؒfYłtBid~gRhAoH̃A|g[VXJnDCGtFN^[JXp[[ƔrāCCjVG[^[JXp[[̊͉̃GtFN^[JXp[[BidȊOقƂǒmĂȂD
@ł́C~gRhAɋǍ݂Bcl-2t@~[^pNCED-9CED-4ĂDvOזENזEłBH3 only proteinłEgl-1̔UĎʁCCed-9Ced-4Ƃ̌Ced-9Egl-1Ƃɒu<a href="#R7"><sup>7)</sup></a>C~gRhA痣ꂽCed-4Ced-3ƌ邱ƂɂCed-3זEs<a href="#R8"><sup>8,9)</sup></a>i<a href="#F2">}2</a>jD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@CVEWEoGCMނɂĕۑꂽזE̎s̃VOioH</strong>
JXp[[oHA|g[VXs̒SIȂ݂ƂĎgĂD
Debcl/BuffyFVEWEoGBcl-2t@~[CDTRAF1DTRAF2FJNK̊ɂA_v^[^pNCDTRAF1͚MނTRAF4CDTRAF2͚MނTRAF6ƑDHtrA2/OmiSmac/DIABLOFƂɍזE̎hɉ~gRhAo^pNŁCݐ̃JXp[[jQ^pNIAPt@~[̋@\jQD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/08/Miura-1.e002-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2012/08/Miura-1.e002-Fig.2.png&amp;caption=fig2-caption-text]

@WanǵCwIȎ@ɂMނɂJXp[[̋@\𖾂炩ɂDނ́CHeLaזE̍זE敪̒otɃnX^[̊̑ɗRjCdATP킦ƃJXp[[3Ċj̋ÏkNƂ<em>in vitro</em>זEUn\zDdATPɈˑIȃJXp[[3̊ɕKvȃ^pNHeLaזE̍זE敪̒ot琸C3Apafiapoptotic protease-activating factorj^pNJXp[[3̊ɕKvȂƂDꂼ̃^pN𐸐č\߂ƂCApaf-1CED-4̃zOCApaf-2̓VgN<em>c</em>CApaf-3̓JXp[[9łDA|g[VX̃VOiזEł́CVgN<em>c</em>~gRhAזEւƕoăA_v^[^pNApaf-1ƕ̂`DVgN<em>c</em>̕o𐧌䂷̂Bcl-2t@~[^pNłDʑ̂ƂApaf-1-VgN<em>c</em>́î̕CA|vg\[ƂԁjɃCjVG[^[JXp[[łJXp[[9N[gCꂪʑ̉邱ƂŊi<a href="#F2">}2</a>jDApaf-1̓VgN<em>c</em>ƌWD40s[gCCED-4ɂ̃hC͂ȂDVEWEoGу}EXɂWD40s[ĝȂApaf-1̃XvCVOoAg݂C̃oAg̓VgN<em>c</em>ɔˑIɃJXp[[łD
@VEWEoGApaf-1͂ق̃^pNKvƂɔʑ̂`CCjVG[^[JXp[[DroncN[gĂDĈɂĂDiap1DroncɌ̊}Ă邽ߍזE͗UȂDDiap1RINGhCrL`K[[łCJXp[[̈萫䂵ĂDזE̎hזEł<em>reaper</em>`qC<em>hid</em>`qC<em>grim</em>`qi<em>RHG</em>`qƂ΂jC̈`qYDiap1ƌ邱Ƃł̎ȃrL`𑣐iւƓĎʁCDronc̊CāC̃GtFN^[JXp[[DriceDcp1A|g[VXU<a href="#R10"><sup>10)</sup></a>i<a href="#F2">}2</a>jD
@JXp[[oHɊւẮCזEÕKhɂJnOoHiɑ΂āC~gRhAoRJXp[[oHoHƂjDFasKh-FasCTNF-TNFễvg^CvƂĒmĂDł͊OoH͒mĂȂCVEWEoGɂTNF̃zOEigerƂ̎eWengenDCJXp[[oHۑĂ킯ł͂ȂCJNK̊ɈˑזEU<a href="#R11"><sup>11)</sup></a>D

<h2>4DɎsזE菜Ƃɂ锭ɂĐmCY̏</h2>
@זE̔ɂĂ͎UIɍזEN邪Ĉ悤ȎזE͂ǂ̂悤ȐזEȂ̂낤DזȆB╪̍ۂɃG[Ĉ悤ȍזẺߒŎ菜邱Ƃ͑zɂȂC͂ĂȂ̂D̂ɂčזẼvZXׂɊώ@邱ƂC̍ۂɃG[̐זE𒲂ׂ邢΂񒼐ړIȕ@łD̂悤Ȍɂ́C1זẺ𑜓xł̐̃C[WO\ŁCClȕ}[J[̗płזEnLłDVEWEoG匊Ɍ`钆wт́C@BeƂĂ͂炭ołDoO̍זEisensory organ precursorFSOPjvj[NX^[ɐĈ̂CΏ̕ɂ芴o킪`D݂̂ɊւĂ͈`wIȌ̖LxȒ~ςC}[J[[ĂDɁCoO̍זE̊OȏSߒ匊ɂĂ炾̕\ʂŋN̂ŁCԂ̈肵̃C[WO\łDoO̍זE̐Ƃ<em>neuralized</em>i<em>neu</em>j`qirL`K[[R[hCNotch̊ɕKvDeltãGhT[g[VX𑣐ij̔IɂȂ邱Ƃł킩DoO̍זE܂Ƃ̍זEDelta𔭌C܂̍זENotchĂ炪_onזEƂȂ̂}邽߁i}jCߐڂזEɊoO̍זE͏oȂƂ`wIȌ玦ĂDƂ낪CoO̍זȄo<em>neu</em>`q̔wWɐ̃C[WOɂώ@ƂCCoO̍זEƂȂזE̋ߖT<em>neu</em>z̍זEo邱Ƃ炩ɂȂD̂悤ȊoO̍זElזÊقƂǂ́CǕ􂵂̂A|g[VXɂ萶̂珜ꂽD
@oO̍זElזE͔Ώ̕C<em>neu</em>`q̔ȂDɊoO̍זEƂȂזEł͂܂̍זEɔNotch݂̊₩ɒቺĂCoO̍זElזEɂ͂܂̍זEƓlɍNotch݂̊ꂽD̊ώ@ʂ́C_onזẼ}[J[ł<em>neu</em>`q𔭌oO̍זElזÉC̐ɖ̐CɎsזEł邱ƂĂD̂悤ȊoO̍זElזE͖{̊oO̍זEɑ΂20̊ŐĈقƂǂ̓A|g[VXɂ莸ꂽD<em>Notch</em>weψّ̂ł20ɊoO̍זEC̕]ȒwтƂCoO̍זElזȄoƃA|g[VX̐ɂ<em>Notch</em>`q̂Ă邱ƂlꂽD̂悤ɁC̃C[WOɂ蕪ɎsזȆ݂炩ɂȂCOo̔zup^[́C}łȂCɂĐG[A|g[VX菜ƂŊ邱ƂꂽDA|g[VX̋@\ƂāC̉ߒŐsvȍזE邢͊댯ȍזȄĂCɂ킦CזEЉ̂ȂōזEꉻĂvZXɂāCɕs̐זE邱Ƃɂ蔭ɂĐmCY̏sĂ邱Ƃ炩ɂȂ<a href="#R12"><sup>12)</sup></a>i<a href="#F3">}3</a>jD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@זEɂ锭ɂĐmCY̏</strong>
_o̔ɂďIj[́CVivXߒ̋ɂ萔̐䂪NDCÏȑOɂC_oO̍זEiKɂĕ̃G[NזEĈ悤ȍזE͍זEɂIIɎ菜ĂDVEWEoGɂOǒ`̉ߒɂẮC2̐_oO̍זEɎs菜ĂDł́CזE1ȏオvOזEɂ菜邪C8_on̍זEł邱ƂlƁC悤ȔɂĐmCY̏@\ƂāC̍זÊȂDҒœł͐_oȞ`̂ƂɁCNGFɑ\_oh{qɂj[̐䂳邱ƂmĂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/08/Miura-1.e002-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2012/08/Miura-1.e002-Fig.3.png&amp;caption=fig3-caption-text]


<h2>5DזEUVOiƌ`Ԍ`</h2>
@ʂ̃A|g[VXώ@锭ۂ̂ЂƂɁCGl?cksmann`Ԍ`ɂזE̗ƂĂƂ肠Ă_oǂ̕D_oǂƂ͔]Ґ̂ƂƂȂ튯łC̐_o̍E̗[̐_oǂƂȂ悤Z_oǕւČ`DvIȐVI`łO]ǂ△]ǁCǗ̍ǂ񕪐Ғł̌̂ЂƂ́C_oǕُ̈łƍlĂDA|g[VXNזE͒ʏ͂ɏĂ܂CoŒ肵ĒׂƂ܂ł̌@ɂ茟oł̂͂ꕔɂȂDɁCMނ̐_oǕ͎q{̓Őis邽ߐ̃C[WOɂώ@͂ނC̑gDwIȌ@ł̓A|g[VX̗LƐ_oǕ̐ۂƂʂ̔肵łC҂̊֌Wڍׂɉ͂邱Ƃ͂ނD
@ŁCזEUVOi̗𒲂ׂړIŁCuGlM[ړifluorescence resonance energy transferFFRETjɂJXp[[̊łv[up̃C[WO͂sꂽĎʁC̐_oǕ̉ߒɂăA|g[VXNזEɂ́CȂƂ2ނ̂ӂ܂邱Ƃ킩DʏCJXp[[3A|g[VXNזE͒fЉCɋߖT̑gDɈݍ܂邱ƂŎ菜邱ƂmĂDC̐_oǕ̉ߒł͂̒fЉ鎀זEɂ킦CfЉɑgDEԂɂƂǂ܂זÊ邱Ƃ炩ɂȂDɁC̃C[WOɂ蓪̐_oǕɂĂ̑x̑肪\ƂȂCA|g[VXjQꍇɂ͐_oǕ̑xɌ邱Ƃ炩ɂȂD܂CA|g[VXƂɂ͐_oǂ̕iނ悤ώ@ꂽĎʂCA|g[VX͓̐_o̌`ԕωɊ^邱ƂŐ_oǕ̉~ȐisɍvĂ邱Ƃꂽ<a href="#R13"><sup>13)</sup></a>D
@Ȕ̉ߒł́C̐_oǕ̂̂}Ȕ]̊g傪邽߁C_oǕ̎ԓɏI邱Ƃ͂̂̔]̔ɂƂɏdvƍlD̂悤ɁCA|g[VX͉~Ȍ`Ԍ`^̐sɂ͂炭ƂŁCȔ]̂ÂɍvĂDA|g[VXɂזECsvȍזȄɂ킦C`Ԍ`^ɕKvȗ͂̐ɂ邱Ƃ́CVEWEoGɂw̕<a href="#R14"><sup>14)</sup></a> CY̊OB̉]^<a href="#R15"><sup>15)</sup></a> łĂDɁCq悤ɁCVOi^pN̕ɂĂ̐isɐϋɓIɂ邱ƂlD

<h2>6DזE</h2>
@19I㔼CRoux́C̔ɂĂזEԂ̋āCK؂Ȃ̂IĂƂ_[EBi_ɉel񎦂D̂̂CזEƂۂIɒm悤ɂȂ̂́CMoratáCVEWEoGp<em>Minute</em>ψكN[̉͂ɂD<em>Minute</em>ψقł̓{\[̍ቺC̃weڍ͖̂쐶^ɔ׍זȆB\D<em>Minute</em>weψّ̂̃N[쐶^̃VEWEoGɂĖȏזȄWcłɌ`ƁC̃N[͂͂ߏȍזEWc邪Ĉ̂CזEWcϋɓIɎĂD̍זEׂĂ<em>Minute</em>weψّ̂łƂɂ͂̂悤Ȍۂ͊ώ@ȂƂC<em>Minute</em>weψّ̂̃N[̏͑B\̈قȂזEWci쐶^<em>Minute</em>weψّ́jꍇɍזEN邽߂łƉ߂ꂽĎۂ̓JXp[[jQ^pNp35̔ɂ}̉\łƂCJXp[[ɂA|g[VX̗Ů֗^Ă邱Ƃ킩<a href="#R16"><sup>16)</sup></a>D
@זE<em>Minute</em>ψكN[ł̂݋N킯ł͂ȂCB\̈قȂזEWcꍇɊώ@Ⴊ񍐂ĂDɂ<em>dMyc</em>`q̔ʂ̈قȂN[`ƁC<em>dMyc</em>`q̔ʂ̏ȂN[̎ӂ̍זEWcꂽD̂悤<em>dMyc</em>`qߏɔזE͒ҁisuper competitorjƂ΂DᐬpזEɂ`q̃XN[jOɂCWarts}`qoHɂ`qi<em>expanded</em>`qC<em>hippo</em>`qC<em>Salvador</em>`qC<em>mats</em>`qC<em>fat</em>`qjɕψقƁC̍זEWc͒҂ƂĂӂ܂ƂꂽDCɐ`qi<em>scribble</em>`qC<em>discs large</em>`qj́C̕ψّ̂͐̉ߑBɂᇂ`邪CɂĕψكN[`ƍזEɂgD珜ꂽDEigerɂזEoH<em>scribble</em>ψكN[Ƃ̍זEɂזEɂ<a href="#R17"><sup>17)</sup></a>DזE̋N鋫Ë킵ׂʁCזEɂ莀łזE͋EɌǂđ݂C񂾍זE͂܂̏זEÐH邱ƂꂽDËɂזEÐH́C񂾍זȄł͂ȂCϋɓIɍזEЂNƂʂ񍐂Ă<a href="#R18"><sup>18)</sup></a>D
@SϑԂVEWEoGł́CcłꂽgD̂قƂǂזEɒuD̑gD̓ւigDč\zjł́CgDזȆBƗcזȄƂċN邪C҂̊֌W͍זEɎƂ낪D̕\gDזÉC̐߂ƑO2̍זEWcƂ̂ɐĈ̗̂cɂG2ɂčזEx~ĂDGNW\̔ɂ匉JnƍĂэזE͂߁C匊15Ԉȍ~ɂ͑gDזE̍זEWc̊gɂȂc̕\זEƒuĂD̂ƂCc̕\זẼA|g[VX}ƑgDזȆB}CtɁCgDזȆB`wIɗ}Ɨc̕\זẼA|g[VX͑啝ɒxꂽƂCA|g[VXƑBƂ݂͑ɂ肠ۂł邱Ƃ킩D
@ɏqׂCJXp[[̊łFRETv[upĐ̃C[WO͂sƂCJXp[[3l̊͗c̕\Ƀ_ɂ݂̂ł͂ȂCgDזEƐڂ鋫Ë̗c̕\זEɂčpxɊώ@ꂽDËɂJXp[[̊͑gDזȆB`wIɗ}ƁC邢́CߎO[U[pċË悾őBx点Ƃ̃JXp[[݂̊͂ȂȂƂCËőBgDזEJXp[[̈SĂ̂ƍlꂽDBƃA|g[VXƂ̘Aւ̋Nĕ҂̋EisĂƂ́CgDŜ̃TCYύXɑgD̓ւȂƂLȂ݂łDBĂ͋ËɂčזEUC܂CזE͋ËɂĂ̑B𑣐i邱ƂŁCRƂזE̓ւ肪N<a href="#R19"><sup>19)</sup></a>DËɂăA|g[VXNזEoꂽDppCߖT̑gDזEɍpĂ̐ZƊg𐧌䂵Ă<a href="#R20"><sup>20)</sup></a>D

<h2>7D㏞B</h2>
@gD͈̐̍זEɂ\ĂāĈɂ͔ĐɂĂȂ炩̕@ɂgD̒葫ۂ݂ĂDזEł́Cɂ蕉זEɂĎẴTCYɕῶȂD͎ꂽזÊ܂̍זEBCK؂ȑgD̃TCYFđB~邩łD̂悤ȍזEɂU鑝Bۂ͑㏞BƂ΂ĂD
@VEWEoǦ㕔ɃGtFN^[JXp[[jQ^pNp35̈`q𔭌Cː̑ŜɃA|g[VXUC邢́CA|g[VXU`qi<em>reaper</em>`q<em>hid</em>`qj<em>p35</em>`qƂ𓯎ɔł́Č㕔ɂčזEUVOi̓IɂȂ邪CGtFN^[JXp[[jQĂ邽߃A|g[VX͑j~ĂiVEWEoG̃CjVG[^[JXp[[Droncp35ɂjQȂjD̎ł́CA|g[VXNȂזElHIɂĂ邱ƂɂȂDƁC㕔ɂčזẺߑBώ@ꂽD̍זEłJNK̊ƍזEB𐧌䂷<em>wingless</em>`q<em>dpp</em>`q̔̏㏸F߂C̃A|g[VXNȂזE͑BVOi𔭂Ă邱ƂꂽDCDppWingless̓A|g[VXNȂזẺߑBɂ͕Kvł邪CQgDŋN㏞Bɂ͕KvȂƂ񍐂Ĉ݂ƂC⏝Q̂Ƃ̑㏞Bɂǂ̂悤ȑBVOî͕sł<a href="#R21"><sup>21)</sup></a>DJXp[[ψّ̂pCGtFN^[JXp[[̊㏞B́̕CCjVG[^[JXp[[Dronc̃xŋN邱Ƃ炩ɂȂ<a href="#R22"><sup>22)</sup></a>Ď㕔ɂ<em>p35</em>`q<em>dronc</em>`qƂ𓯎ɔƁCgĎJNK̊C<em>p53</em>`q̔Uώ@ꂽDJNK͍זEXgXɂ芈邪CDronc̉ɂ<em>p53</em>`q̔UꂽƂ́C<em>p53</em>`qDNȀQ݂̂Ȃ炸CזẼXgXmĊ邱ƂĂ<a href="#R23"><sup>23)</sup></a>D
@̂悤ɁCB̍gDłDronc̉ɂđBVOi̔邱ƂĂ邪CG1ōזE̒~Ăᐬ̈ꕔ̍זEWc<em>hid</em>`q̔ɂזEUƁC̍זEWcHedgehog傳G1ōזE̒~Ă܂̍זEɑ㏞B̗U邱Ƃꂽ<a href="#R24"><sup>24)</sup></a>Ďnɂ<em>dpp</em>`q<em>wingless</em>`q֗^CC<em>dronc</em>`qł͂Ȃ̉̃GtFN^[JXp[[R[h<em>drice</em>`q<em>dcp1</em>`q㏞BɕKvłD̂悤ɁC㏞B͍זE̗UזEWcɂCقȂJXp[[ɈˑċNĂ邱Ƃ킩D
@זEƑ㏞B͂ƂɑIȐۂłƍli<a href="#F4">}4</a>jDזEi<em>Minute</em>weψّ̂Ɩ쐶^̐ڐGC邢́C<em>dMyc</em>`q̔ʂ̈قȂזEWc̐ڐGj̏ɂĎłזEWc<em>p35</em>`q𔭌čזE}ĂCߏȑ㏞B͊ώ@ȂDזEɂזE͂̋ËŋN邪CA|g[VXNȂזE̎nł̓N[̑ŜɂčזEUVOiIɂȂĂDVOi𔭂זEɂďWcʁicommunity effectjĂ̂ǂ̈ႢȂ̂ȂD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@זEƑ㏞B</strong>
זEƑ㏞B͑זÊ݂tB[hobNɂP퐫݂̂ƂȈێ@\łDזEWĉȂɓKxɗזEƁCזEɂ肻̍זE͐ϋɓIɍזENDזEłߒł͑BqoC܂̍זȆBDBq󂯎זE͂܂̍זEɔדKx߁CזEЂNꂤD̂悤ȍזȆ݂̓Kx̊Ď@\͂炭ƂɂCזEWc̎ۂ̂ƍlD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2012/08/Miura-1.e002-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2012/08/Miura-1.e002-Fig.4.png&amp;caption=fig4-caption-text]

@葫miquorum sensingCNIZVOj͍׋ۂɂĂ݂ۂŁC含̉wpďWc̖x݂ɊmCwiI[gCf[T[j̔ZxƈĂɂɉsƂƂ̂łDa^pN̎YCזE̗Uɂ׋ۏWc̎IȊǗC̋@\ɂ萧䂳Ă<a href="#R25"><sup>25)</sup></a>D葫mɂזE̗ÚCIȍsׂɂWcƂĂ̌퐫ۂ͂炫̂ƍlĂ<a href="#R26"><sup>26)</sup></a>DזEł悤Ȃ݂͂炢Ă̂Ƒz肳邪CI[gCf[T[̂悤Ȓ葫mɂ镪q͖̎̂炩ɂĂȂD

<h2>8DgD̍ĐƍזEUVOi</h2>
@זE㏞B́C΁CgD̏CɂP퐫̈ێ@\ƂƂ炦邱ƂłCĐƗގDgDƂזEЉ͍זEƑBƂ̃oXɂ肻̍P퐫ێĂDAtJcKGɂăI^}WNV̔ؒfƂꂪĐ邪C̍ۂɂ͍Đ̈ꕔɂăJXp[[3̊ώ@C̊jQ܂ɂ}ƍזEƍזEB̑jQNĐȂȂ<a href="#R27"><sup>27)</sup></a>D̂Ƃ́CVEWEoG̕ϑԂ̍ۂ̕\̍ĕҐƓlɁCזEBɐϋɓIɂ邱ƂĂD
@Đ̍ۂ̑㏞B̓qhp玦ꂽDqhݒî̂قڒj2ƁC̍Đ̈ɂ̓A|g[VXɂ݂D̃A|g[VXNזEWnt3𔭌܂̍זȆB𑣂DJXp[[jQ܂ƃA|g[VX}CCĐNȂȂDWnt3mbN_EƂ͂Đ͑jQꂽƂCł̑㏞BɂWnt3KvȂƂꂽ<a href="#R28"><sup>28)</sup></a>D
@1900N㔼΁CHadorńC̈ꕔؒfĂ琬̕oɂǂĂƁCŐؒfʂĐƂnmDؒf[łJNK̊NC̊`wIɗ}Ƒ̎NȂȂDȓO㎲̋EɂDppĂ邪C̗̈̂Ƃwweak pointƂ΂ʂȏꏊDweak pointɂ悤ɐؒfĐoɂǂƁCĐ̂Ƃrւ̓̕]pxɋNDؒfɂJNK̊<em>Polycomb</em>Q̈`q}C<em>Polycomb</em>Qɂ]ʂ̗}ẴZN^[`q<em>vestigial</em>̔U<a href="#R29"><sup>29)</sup></a>D̋rւ̓̕]͋r<em>wingless</em>`qߏɔ邱ƂɂĂN邪C̎nɂĂؒf̂ƂƓlɑB̂ȉ̂weak pointɐ<a href="#R30"><sup>30)</sup></a>C<em>vestigial</em>`q̔UN<a href="#R31"><sup>31)</sup></a>D<em>p53</em>`q<em>dronc</em>`qɕψق̂ꍇĈ̌`͑傫ቺƂCĐ̂Ƃ̑B╪̓]ɂ㏞BɂĎgĂזEUVOi֗^Ă̂ƍlꂽ<a href="#R23"><sup>23)</sup></a>DᐬɃJXp[[jQ`q<em>diap1</em>̕ψكN[`C<em>p35</em>`q𔭌đ㏞B𑣂ƁCgD̔ɂ킦̈ꕔɐGpl̓̕]N<a href="#R32"><sup>32)</sup></a>D

<h2></h2>
@ɂčP퐫ێ邵݂̂ȂŁC̃tB[hobN͂ȂĂ͂ȂvZXłDJacobMonod咰ۂɂĔNg[XIýCӎYɂ`q̔}𐧌䂷邵݂łDP퐫זEWcƂC}NȃxōlƁC咰ۂEDFƂ5̃A~m_cȂyv`hI[gCf[T[ƂčזEOɕo邱ƂɂCזEUWcƂẲߏȑB𕉂ɐ䂵Ă<a href="#R33"><sup>33)</sup></a>DPזEB̂Ƃ͈قȂC󐸗d˂锭̉ߒł́CזE̐ɕω邱ƂɂCψȍזEWc̑߂ɗ}̂邵݂܂ʂĂ悤ɂ݂DCVEWEoG̐̌`CҒœ̈ȍ~̃Xe[WɂĂ܂Ƃ܂זEWcłgDƂɂ́CgD\זE̒葫䂪KvɂȂĂDɂ͑gD̍P퐫ۂߍזÊ݂Ă͂łCזE㏞B͂̊{IȂ݂ƍl邱Ƃł悤DɂזEЉ̊拭P퐫𗝉邤ŁCזE͂˂ɔOɂׂۂȂ̂łD

<h2> </h2>
<ol>
<li id="R1"><span class='au'>Hambruger, V.</span>: <span class="ti">History of the discovery of neuronal death in embryos.</span> <span class='so'>J. Neurobiol., 23, 1116-1123 (1992)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/1469378" target="_blank">PubMed</a>]</span></li>
<li id="R2"><span class='au'>Glucksmann, A.</span>: <span class="ti">Cell death in normal vertebrate ontogeny.</span> <span class='so'>Biol. Rev., 26, 59-86 (1951)</span></li>
<li id="R3"><span class='au'>Kerr, J. F., Wyllie, A. H. & Currie, A. R.</span>: <span class="ti">Apoptosis: basic biological phenomenon with wide-ranging implications in tissue kinetics.</span> <span class='so'>Br. J. Cancer, 26, 239-257 (1972)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/4561027" target="_blank">PubMed</a>]</span></li>
<li id="R4"><span class='au'>Martin, D. P., Schmidt, R. E., DiStefano, P. S. et al.</span>: <span class="ti">Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.</span> <span class='so'>J. Cell Biol., 106, 829-844 (1988)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/2450099" target="_blank">PubMed</a>]</span></li>
<li id="R5"><span class='au'>Ellis, H. M. & Horvitz, H. R.</span>: <span class="ti">Genetic control of programmed cell death in the nematode <em>C</em>. <em>elegans</em>.</span> <span class='so'>Cell, 44, 817-829 (1986)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/3955651" target="_blank">PubMed</a>]</span></li>
<li id="R6"><span class='au'>Hengartner, M. O., Ellis, R. E. & Horvitz, H. R.</span>: <span class="ti"><em>Caenorhabditis elegans</em> gene <em>ced-9</em> protects cells from programmed cell death.</span> <span class='so'>Nature, 356, 494-499 (1992)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/1560823" target="_blank">PubMed</a>]</span></li>
<li id="R7"><span class='au'>Yan, N., Chai, J., Lee, E. S. et al.</span>: <span class="ti">Structure of the CED-4-CED-9 complex provides insights into programmed cell death in <em>Caenorhabditis elegans</em>.</span> <span class='so'>Nature, 437, 831-837 (2005)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16208361" target="_blank">PubMed</a>]</span></li>
<li id="R8"><span class='au'>Chinnaiyan, A. M., OfRourke, K., Lane, B. R. et al.</span>: <span class="ti">Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death.</span> <span class='so'>Science, 275, 1122-1126 (1997)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/9027312" target="_blank">PubMed</a>]</span></li>
<li id="R9"><span class='au'>Yang, X., Chang, H. Y. & Baltimore, D.</span>: <span class="ti">Essential role of CED-4 oligomerization in CED-3 activation and apoptosis.</span> <span class='so'>Science, 281, 1355-1357 (1998)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/9721101" target="_blank">PubMed</a>]</span></li>
<li id="R10"><span class='au'>Kuranaga, E. & Miura, M.</span>: <span class="ti">Nonapoptotic function of caspases: caspases as regulatory molecules for immunity and cell-fate determination.</span> <span class='so'>Trends Cell Biol., 17, 135-144 (2007)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17275304" target="_blank">PubMed</a>]</span></li>
<li id="R11"><span class='au'>Kanda, H., Igaki, T., Okano, H. et al.</span>: <span class="ti">Conserved metabolic energy production pathways govern Eiger/TNF-induced non-apoptotic cell death.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 108, 18977-18982 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22065747" target="_blank">PubMed</a>]</span></li>
<li id="R12"><span class='au'>Koto, A., Kuranaga, E. & Miura, M.</span>: <span class="ti">Apoptosis ensures spacing pattern formation of <em>Drosophila</em> sensory organs.</span> <span class='so'>Curr. Biol., 21, 278-287 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21276725" target="_blank">PubMed</a>]</span></li>
<li id="R13"><span class='au'>Yamaguchi, Y., Shinotsuka, N., Nonomura, K. et al.</span>: <span class="ti">Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure.</span> <span class='so'>J. Cell Biol., 195, 1047-1060 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22162136" target="_blank">PubMed</a>]</span></li>
<li id="R14"><span class='au'>Toyama, Y., Peralta, X. G., Wells, A. R. et al.</span>: <span class="ti">Apoptotic force and tissue dynamics during <em>Drosophila</em> embryogenesis.</span> <span class='so'>Science, 321, 1683-1686 (2008)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/18802000" target="_blank">PubMed</a>]</span></li>
<li id="R15"><span class='au'>Kuranaga, E., Matsunuma, T., Kanuka, H. et al.</span>: <span class="ti">Apoptosis controls the speed of looping morphogenesis in <em>Drosophila</em> male terminalia.</span> <span class='so'>Development, 138, 1493-1499 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21389055" target="_blank">PubMed</a>]</span></li>
<li id="R16"><span class='au'>Moreno, E., Basler, K. & Morata. G.</span>: <span class="ti">Cells compete for decapentaplegic survival factor to prevent apoptosis in <em>Drosophila</em> wing development.</span> <span class='so'>Nature, 416, 755-759 (2002)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/11961558" target="_blank">PubMed</a>]</span></li>
<li id="R17"><span class='au'>Igaki, T., Pastor-Pareja, J. C., Aonuma, H. et al.</span>: <span class="ti">Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in <em>Drosophila</em>.</span> <span class='so'>Dev. Cell, 16, 458-465 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19289090" target="_blank">PubMed</a>]</span></li>
<li id="R18"><span class='au'>Ohsawa, S., Sugimura, K., Takino, K. et al.</span>: <span class="ti">Elimination of oncogenic neighbors by JNK-mediated engulfment.</span> <span class='so'>Dev. Cell, 20, 315-328 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21397843" target="_blank">PubMed</a>] [<a href="http://first.lifesciencedb.jp/archives/2710" target="_blank">V_r[</a>]</span></li>
<li id="R19"><span class='au'>Nakajima, Y. -I., Kuranaga, E., Sugimura, K. et al.</span>: <span class="ti">Non-autonomus apoptosis is triggered by local cell cycle progression during epithelial replacement in <em>Drosophila</em>.</span> <span class='so'>Mol. Cell Biol., 31, 2499-2512 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21482673" target="_blank">PubMed</a>]</span></li>
<li id="R20"><span class='au'>Ninov, N., Menezes-Cabral, S., Prat-Rojo, C. et al.</span>: <span class="ti">Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis.</span> <span class='so'>Curr. Biol., 20, 513-520 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20226662" target="_blank">PubMed</a>]</span></li>
<li id="R21"><span class='au'>Perez-Garijo, A., Shlevkov, E. & Morata, G.</span>: <span class="ti">The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the <em>Drosophila</em> wing disc.</span> <span class='so'>Development, 136, 1169-1177 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19244279" target="_blank">PubMed</a>]</span></li>
<li id="R22"><span class='au'>Kondo, S., Senoo-Matsuda, N., Hiromi, Y. et al.</span>: <span class="ti">DRONC coordinates cell death and compensatory proliferation.</span> <span class='so'>Mol. Cell. Biol., 26, 7258-7268 (2006)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16980627" target="_blank">PubMed</a>]</span></li>
<li id="R23"><span class='au'>Wells, B., Yoshida, E. & Johnston, L.</span>: <span class="ti">Compensatory proliferation in <em>Drosophila</em> imaginal discs requires Dronc-dependent p53 activity.</span> <span class='so'>Curr. Biol., 16, 1606-1615 (2006)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16920621" target="_blank">PubMed</a>]</span></li>
<li id="R24"><span class='au'>Fan, Y. & Bergmann, A.</span>: <span class="ti">Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the <em>Drosophila</em> eye.</span> <span class='so'>Dev. Cell, 14, 399-410 (2008)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/18331718" target="_blank">PubMed</a>]</span></li>
<li id="R25"><span class='au'>Bassler, B. L. & Losick, R.</span>: <span class="ti">Bacterially speaking.</span> <span class='so'>Cell, 125, 237-246 (2006)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16630813" target="_blank">PubMed</a>]</span></li>
<li id="R26"><span class='au'>Erental, A., Sharon, I., Engelberg-Kulka, H.</span>: <span class="ti">Two programmed cell death systems in <em>Escherichia coli</em>: an apoptotic-like death is inhibited by the <em>mazEF</em>-mediated death pathway.</span> <span class='so'>PLoS Biol., 10, e1001281 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22412352" target="_blank">PubMed</a>]</span></li>
<li id="R27"><span class='au'>Tseng, A., Adams, D., Qiu, D. et al.</span>: <span class="ti">Apoptosis is required during early stages of tail regeneration in <em>Xenopus laevis</em>.</span> <span class='so'>Dev. Biol, 301, 62-69 (2007)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17150209" target="_blank">PubMed</a>]</span></li>
<li id="R28"><span class='au'>Chera, S., Ghila, L., Dobretz, K. et al.</span>: <span class="ti">Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration.</span> <span class='so'>Dev. Cell, 17, 279-289 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19686688" target="_blank">PubMed</a>]</span></li>
<li id="R29"><span class='au'>Lee, N., Maurange, C., Ringrose, L. et al.</span>: <span class="ti">Suppression of Polycomb group proteins by JNK signalling induces transdetermination in <em>Drosophila</em> imaginal discs.</span> <span class='so'>Nature, 438, 234-237 (2005)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16281037" target="_blank">PubMed</a>]</span></li>
<li id="R30"><span class='au'>Johnston, L. A. & Schubiger, G.</span>: <span class="ti">Ectopic expression of wingless in imaginal discs interferes with decapentaplegic expression and alters cell determination.</span> <span class='so'>Development, 122, 3519-3529 (1996)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/8951067" target="_blank">PubMed</a>]</span></li>
<li id="R31"><span class='au'>Sustar, A. & Schubiger, G.</span>: <span class="ti">A transient cell cycle shift in <em>Drosophila</em> imaginal disc cells precedes multipotency.</span> <span class='so'>Cell, 120, 383-393 (2005)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15707896" target="_blank">PubMed</a>]</span></li>
<li id="R32"><span class='au'>Ryoo, H. D., Gorenc, T. & Steller, H.</span>: <span class="ti">Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.</span> <span class='so'>Dev. Cell, 7, 491-501 (2004)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15469838" target="_blank">PubMed</a>]</span></li>
<li id="R33"><span class='au'>Kolodkin-Gal, I., Hazan, R. & Gaathon, A.</span>: <span class="ti">A linear pentapeptide is a quorum-sensing factor required for <em>mazEF</em>-mediated cell death in <em>Escherichia coli</em>.</span> <span class='so'>Science, 318, 652-655 (2007)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17962566" target="_blank">PubMed</a>]</span></li>
</ol>

<h2>Ql}</h2>
<ol>
<span class='au'>Җ{p </span>: <span class="ti">זEEA|g[VXW}X^[</span>. <span class='so'>ry (2006)</span>
</ol>
<ol>
<span class='au'>OYK </span>: <span class="ti">זEWҁiwj</span>. <span class='so'>ry (2010)</span>
</ol>
<ol>
<span class='au'>Douglas R. Green, cd Ė</span>: <span class="ti">ւ̓؁FA|g[VXƂ܂܂ȍזE</span>. <span class='so'>fBJETCGXEC^[iVi (2012)</span>
</ol>
<ol>
<span class='au'>Miura, M. (ed.)</span>: <span class="ti">Cell death in development and regeneration.</span> <span class='so'>Dev. Growth Differ. 53(2) (2011)</span>
</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">OY KiMasayuki Miuraj</span>
F1988N ww@wȔmے CCN  mC1989N c`mww C1992N čMassachusetts General HospitalmC1995N }gwbwn utC1997N ww C2001N w]ȊwZ^[ `[[_[oāC2003N蓌ww@wn D
e[}FזE݂זEЉ̐ƈێ̋@\Dgq̂͂炫͍זEЉŒׂhbg[ɁC̃xł̕q@\̉͂sĂD
URLF<a href="http://www.f.u-tokyo.ac.jp/~genetics/index.html" target="_blank">http://www.f.u-tokyo.ac.jp/~genetics/index.html</a>
</div>
? 2012OY KLicensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
