Cn-k玿ɂԔFmVXe

<strong>k얁EB</strong>
iww@wn qs_oȊwj
emailF<a href="mailto:kitanishi@mbn.med.osaka-u.ac.jp">k얁</a>C<a href="mailto:n-matsuo@mbn.med.osaka-u.ac.jp">B</a>
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̈Zr[, <strong>4</strong>, e001 (2015)@<a href="http://dx.doi.org/10.7875/leading.author.4.e001">DOI: 10.7875/leading.author.4.e001</a>
Takuma Kitanishi & Naoki Matsuo: <strong>Spatial representation system in the hippocampal-entorhinal circuit.</strong>

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<h2>v </h2>
@t̊Cn-k玿ɂ́CꏊזECiqזECזE݂D̃j[́CǂIuWFNgȂǊOẼh}[NƂԑIIȔ΂C̋ԔFmgn}hƂĂ͂炭ƍlĂD܂COE̕ωAwKɑ΂銈p^[̗lԂCԋLGs\[hLɂ֗^ƍlDߔNɂȂCԑIIȊp^[𐶐H@\эזE@\̉𖾂ɂނʂȌAv[`Kp悤ɂȂ茤ĂD

<h2>͂߂</h2>
@2014Ñm[xww܂́Cg]̋ԔFmɊւזE̔hɂāCJohn O'KeefeiWEIL[tjCMay-Britt Moseri}CubgE[U[jCEdvard I. MoseriGh@hE[U[j3Ɏ^ꂽD̃r[́C܂̑ΏۂƂȂꏊזEъiqזEƂ͂ǂ̂悤ȍזEȂ̂D܂C̍זE`H@\LƂ̊֘AɂāCŐV̒m܂c_D

<h2>1DꏊזE̔</h2>
@g܎ǂɂ̂HhƂԔFḿCꂪĂ߂ɏdv{IȊołDԂ̂Ȃł̎̋ꏊF邱ƂłȂ΁CmȂyn𗷂邱Ƃ͂C̒ʋ΂܂܂ȂȂDԔFm\͂̒ቺ͔Fmǂ̒jǏłDԂ𐳂Fm邽߂ɁC]͂ǂ̂悤Ȃ݂Ă̂낤D
@1971NCO'KeeféCԂ̂Ȃł̓̈ʒuɔĊj[݂邱Ƃ𔭌<a href="#R1"><sup>1)</sup></a>ĎsꂽCłɊCnƂ]ʂLɂďdvłƍlĂ<a href="#R2"><sup>2)</sup></a>DŔނ́CgJɂCs̓̔]_ov铖̐[ZpCnɓKp邱ƂɂDCnɗudɂăbĝȂŎRɊƂ̐_ovƂCbĝȂ̓̏ꏊœ̕ނƂɂj[݂邱ƂoD̂̂CI𐫂͎͕ʓIȍL̂镔ł͎キiC1̒ʘH̊ł͌ȕI𐫂jC̏ꏊʂ蔲ƂɂɊ邱Ƃ킩DꂪꏊזEiplace celljłi<a href="#F1">}1a</a>jD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@ꏊזEƊiqזE</strong>
iajꏊזÉC̂Ȃ̓̏ꏊʂ蔲Ƃɂ̂݊D̈ړ̋OՂDF̐ŁCזE̔Ί̈ʒuԐF̓_ŎDꏊזE΂ꏊiԐFjꏊeƂԁDꏊëʒu͌X̏ꏊזEɂقȂD
ibjObhזÉC̂Ȃ̏̕ꏊŊC̏ꏊOp`߂iq̒_ɈʒuD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/01/Matsuo-4.e001-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2015/01/Matsuo-4.e001-Fig.1.png&amp;caption=fig1-caption-text]

@ꏊזEΊ߂ꏊłꏊéCꏊזEƂɂ܂܂łDƂ΁CꏊזÊ͕pŊCʂ̏ꏊזE͕̒SŊƂłDāC̏ꏊזEW߂ƁCꏊe삪̕܂ŜD̂߁CꏊזE̊ǂݎ邱ƂɂtɁC܂ǂɂ邩\łDہCɌv\̏ꏊזE10 cmȉ̌덷Ńbǧ݈ʒu𐄒ł<a href="#R3"><sup>3)</sup></a>D܂CꏊזÊ킾ƂāC̊oɈˑȂƂDƂ΁CÈłɂĎo΂ĂꏊזE̊͂ƂǂێDkoCGoCȍsvł<a href="#R4"><sup>4)</sup></a>DɁCJ[gɏ悹ēĂꏊIIȊ͐邱ƂCƂ^w߂̏K{ł͂Ȃ<a href="#R5"><sup>5)</sup></a>DāCꏊזE͓̊̊oɂ`Ɍ܂̂ł͂ȂC܂܂ȏ𓝍ʂƂāC]IɐԔFm𔽉f̂ƍlD̂悤ȓCꏊזE͔Fmn}̐_oՂłƒ񏥂ꂽ<a href="#R6"><sup>6)</sup></a>D
@ꏊזE̊p^[͖ȖɒׂĂD܂܂Ȃ̊i~`Cp`CC8̎^CE^CWOUO^jCv[<a href="#R7"><sup>7)</sup></a>CXy[XVg̖d͋<a href="#R8"><sup>8)</sup></a> ȂǁClȊɂďꏊIIȊmFĂD܂Cbgɂ킦C}EXCRECTłꏊזE݂ĂDȂCREĂƂ̏ꏊe͋`iɂ蔭Ηςjł̂ɑ΂<a href="#R9"><sup>9)</sup></a>Cbg点Kiǂoۂ̏ꏊe͉ɉтĂ荂̕\Ⴂ<a href="#R10"><sup>10)</sup></a>DqgɂĂCfBXvCz̃o[`ȊɂĂł͂邪CꏊIIɊj[݂̑mFĂ<a href="#R11"><sup>11)</sup></a>DꏊזE͚Mނɋʂ̕ՓIȋԔFmVXe\ƍlD

<h2>2DꏊזẺUw</h2>
@Cn̍\ɖڂނāCꏊזE̓ɂĂ肭킵݂Ăi<a href="#F2">}2</a>jDCnCA1삨CA3̐̍זEƎזEꏊזEƂĂ̊p^[CݍזE͂̕ʂɂĂmȏꏊI𐫂ȂƂiC̏ꍇCݍזEۂƂזE̕ނ͎œdCwIȓɂƂÂĂCꂪgDwIȕނƌɍv邩͕słjD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@Cn̍\</strong>
iajbg̖͎̓}D
ibjbg̔]𑤕݂}DCnњk玿́CꂼꍶȆ]1΂݂Cw-̕ɍג`ƂD
icjCn̐fʁDCnCA1삨CA3̐̍זEƎזE͋̓ˍזEłCقɁCꂼ̗̈ɑlȉݍזE݂DˌoHƂẮCk玿CA3쁨CA1Ƃ߂gVivXoHCk玿CA1ɒړ͂玿-AjoHȂǂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/01/Matsuo-4.e001-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2015/01/Matsuo-4.e001-Fig.2.png&amp;caption=fig2-caption-text]

@ꏊזE̊p^[͊O̊ɉēIuɍĔzu邱ƂmĂC̍Ĕzu̗lԂ̈ɂقȂĂDĔzuɂ́Cꏊe삪ωIȍĔzuCꏊe͕ς炸Ηωpx̍ĔzuD̌`𐳕`~`ւƂɕό`ƂCA1ɂĔzû悤킵ׂC`̕ω킸Ȃꏊe͂悻ɕۂC`̕ω傫ȂƏꏊe삪ĂɕIȍĔzuƂoꂽ<a href="#R12"><sup>12)</sup></a>Ďʂ́CꏊזÉCω邢͌񂩂S̑⊮p^[ƁCOÊ킸ȕωsqɋʂp^[̗sƂĂDp^[CA1̏㗬ł鎕CA3삪N_ƍlĂDł́C̏ꏊזȄ͕ꏊeC̂킸ȍقɂ肨̂̂̏ꏊeɂ锭Ηsqɕω<a href="#R13"><sup>13)</sup></a>DCA3ł͊̂킸ȕω͕px̍ĔzuƂĕ\Cω傫ȂƂ܂ŔΗ̒Ⴉj[VɏꏊזEƂĊ͂߂CtɁCĂꏊזEȂȂƂĔzu<a href="#R13"><sup>13,14)</sup></a>D
@̈̂ł̐̈Ⴂɂ킦C̈ɂĂC̎iw-C߈-ʁC\w-[w3jɂʒuɂꏊזE͈̐قȂĂDȂ̂́CCn̔w-ɂꏊẽTCY̕ωłDbgɒʘH^ɑ点ꍇCwCA3̏ꏊẽTCY͖1 mCɂނقǑ傫ȂCƂł10 mɒB<a href="#R15"><sup>15)</sup></a>D̏ꏊזE͂܂Ȋ\Cwł͂̊̂Ȃł̏ڍׂȈʒuCƂ@\̂̕ȂD
@߈-ʂƂł͏ꏊI𐫂قȂDk玿狭˂߈CA1́COk玿̓˂鉓CA1ԑI𐫂<a href="#R16"><sup>16)</sup></a>Dk玿ɂ͂̂ɏqׂiqזE݂COk玿̃j[͖mȋԑI𐫂C̋Ԃ邢͔ԂƂ̎IȍقCA1̋߈-ʎɔfƍlĂD
@܂CCA1̐̍זEwɂ͕\w-[w̎ɐ̍זE5`8wقǂȂł邪CꏊזEƂȂ銄┭΃p^[̓\wƐ[wƂňقȂ<a href="#R17"><sup>17)</sup></a>D̂悤ɁCCnɂ̈̈̓ł̈ʒuɂCقȂ\ꏊזEzĂD

<h2>3DꏊזEƋL</h2>
@ꏊזE͊CnɈˑԋLGs\[hLɐ[֗^ƍlĂDwKɂƂȂꏊזE̓Iȕω̗݂Ă݂悤D
@VȊTƁCȏꏊזE̊琔\̂Ɍ`<a href="#R18"><sup>18)</sup></a>CȂJ<a href="#R19"><sup>19,20)</sup></a> ɓɂĂp^[ČꂤDꏊזE̊p^[́C̂̂ɂĂ̋ԋĽ`шێ𔽉f悤ɂ݂D
@̂̊wKɂ킦CԏƂق̏ƂAwKɂĂꏊזE͕̊ωDƂ΁C̂ȂœdCVbN鋰|twKɂꏊe삪Ĕzu<a href="#R21"><sup>21)</sup></a>D܂CHwKsƃS[n_ɏꏊe삪Wς<a href="#R7"><sup>7)</sup></a>C̏ꏊɉBꂽW߂ۑł́ĈꏊւƏꏊe삪Ĕzu<a href="#R22"><sup>22)</sup></a>Dꏊe͓ɂƂdvȈӖꏊɏWIɔzûȂD
@̂悤ȋԏƂق̏Ƃ̘A͂ǂ̔]ʂɂčŝ낤D́CCnɂ͂܂܂Ȋo͂Ă<a href="#R23"><sup>23,24)</sup></a>Ĉ̈ʒu<a href="#R25"><sup>25)</sup></a>C<a href="#R26"><sup>26)</sup></a> ɂ蔭Εpx̕ωj[݂DɁC̃j[͂΂ΏꏊI𐫂˔<a href="#R26"><sup>26)</sup></a>D̏A_oCwKɂꏊזE̍ĔzůՂȂ̂ȂD

<h2>4DiqזE</h2>
@ԏ̏͊Cnōs킯ł͂ȂD2005NCMay-Britt MoserEdvard I. Moser̃O[v́Ck玿ɊiqזE݂邱Ƃ𔭌i<a href="#F1">}1b</a>jD2lO'KeefěŊw񂾂̂C͏ꏊזĚsĂCɊCnւ̓o͂Sk玿ɖڂނ悤ɂȂDk玿ƊCn͔wǂѕǂɘAĂD܂Cɏqׂ悤ɁCCnł͔w̏ꏊזEقǉsꏊI𐫂D̉UwIȊ֌WCk玿ɂĂwقǋԏ̏ɏdvƗ\zC̕ʂ_ovDĎۂɁCꏊIIȔΊoƂɐ<a href="#R27"><sup>27)</sup></a>Dk玿̃j[́CꏊזEƂ͈قȂC̂Ȃő̎eĂD̎e̔z݂߂邽߁C傫ȊpċL^sƂe삪Op`߂iq̒_ɋKIɔzu邱Ƃ𔭌CiqזEigrid celljƖÂ<a href="#R28"><sup>28)</sup></a>DقǊiqזE̎e̊Ԋug傷邱Ƃ킩D̂ɁCiqזE͑OCnxrіTCnxrɂĂ݂Ă<a href="#R29"><sup>29)</sup></a>DiqזE̎ê̋͊ɂ炸悻łD܂CiqזE͏ꏊזEƂ͈قȂCǂ̊łÂoɂeقǂȂiC_<a href="#R30"><sup>30,31)</sup></a> QƂ̂ƁjD̐Cނ́CiqזE͕ՓIȋ̎wWłƒ񏥂ĂD

<h2>5D̂ق̋ԑIIȃj[</h2>
@Cn-k玿ɂ́CقɂԑIIȃj[݂i<a href="#F3">}3</a>jDOCnxrɂāC̓̌ɔĔ΂铪זEihead direction celljĂ<a href="#R32"><sup>32,33)</sup></a>D̂̂CזE͓k玿CwWjCO̊jCOjCc㕔玿CTCnxrɂ݂ƕ񍐂ꂽ<a href="#R34"><sup>34)</sup></a>D܂CCnxrɂ́C̕̋ɕǂ݂ƂɊ鋫ExNgזEiboundary vector cellj݂Ă<a href="#R35"><sup>35)</sup></a>Dk玿ɂ́CiqזEƓזE̗̐킹RWNeBuזEiconjunctive cellj<a href="#R36"><sup>36)</sup></a>CǍۂȂǂ̊̒[ɂƂɊ{[_[זEiborder cellj݂<a href="#R37"><sup>37)</sup></a>D܂COk玿̃j[́Ĉꏊł͂ȂĈȂɒuꂽIuWFNg̏ꏊɔ<a href="#R38"><sup>38)</sup></a>D

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@Cn-k玿ɑ݂ԑIIȃj[</strong>
bg̔]ƁC̖fʁD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2015/01/Matsuo-4.e001-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2015/01/Matsuo-4.e001-Fig.3.png&amp;caption=fig3-caption-text]

@܂܂ȋԏ͂ǂ̂悤ɓĊp̂낤H@̂ЂƂ̉́CoHϕƃh}[Nɂ␳Ƃgݍ킹ԃirQ[Vł<a href="#R39"><sup>39)</sup></a>Dݒnʂ̒n_ւƐ^ړ邱Ƃz肵Ă݂悤D܂CꏊזEݒnCזEړDiqזE̎IȔΊړ̎wWƂėpƓn_̍WvZłD݂ɂԂ΁CCӂ̋ȐɂoHϕɂirQ[VƂȂDCoHϕ͓IȋԏpirQ[VłCɎƂ̌덷~ςDExNgזE{[_[זE͕ǂIuWFNgȂǊOẼh}[N̋𑪂蒼CoHϕ̌덷C邽߂ɖĂ̂ȂD

<h2>6DԑIIȐ_ỏH@\эזE@\</h2>
@ԑIIȃj[͊Cn-k玿ɖWĂC̊ɂ͂Ȃ炩̑ݍpƑz肳DCݍpԑIIȊ`邽߂̉H@\ɂ́C܂sȓ_D
@iqזE񍐂ꂽCiqזE̓͂ďꏊזE`Ƃf񏥂ꂽ<a href="#R40"><sup>40)</sup></a>DiqזE͊Cnɓ˂\w̚k玿ɑ݂<a href="#R36"><sup>36)</sup></a>CۂɁCCnւƓ˂dCwIȏ؋邱Ƃ<a href="#R13"><sup>13,41)</sup></a>C̉͂񍇗IɎvDCߔŇ́C̃fɋ^𓊂mW܂ĂDCnњk玿ɓ˂uj}ƁCiqזE̊̎ɂ炸ꏊזE̊ɂ͉e<a href="#R42"><sup>42)</sup></a>CV̊ɂĂ͐VꏊזE`邱Ƃ񍐂ꂽ<a href="#R43"><sup>43)</sup></a>DɁCw畠ɂk玿Sɔj󂵂ꍇłCꏊזE͕̊IɂQȂ<a href="#R44"><sup>44)</sup></a>Dɑ΂CtɁCCn̊}ƊiqזE̊<a href="#R45"><sup>45)</sup></a>Dk玿ƊCńC㗬ƉƂ̊Kw֌Wł͂ȂCݍpɂȋԕ\鑊IȃVXeȂ̂ȂDCꏊזEiqזÊԏ͂ǂ̔]̈悩炳̂낤H@זẺZɂiqזE`ƂCExNgזẺZɂꏊe삪`Ƃ邪Č҂D
@㗬̓̓p^[̂ɂ킦āC̓͂VivXăj[ɓ`BԑIIȊ̊mɂĂ͏dvł낤DVivXYɂ`Bx̕ώCL̊ՂƂȂזE@\łƂƂɁCꏊזĚ`шێɂ֗^邱ƂĂDVivXY}NMDAȇjQ𕠍oɓ^ƁCꂽɂꏊזE͉̊eȂ̂́CV̊ɂČ`ꂽꏊזE̊̒萫<a href="#R46"><sup>46)</sup></a>D܂C̈IINMDAêmbNAEgꍇɂ́CԋL̏QƂƂɏꏊזE̔΃p^[<a href="#R47"><sup>47)</sup></a>DVivXYɊ֗^^pNƂāCقɂCaMKII <a href="#R48"><sup>48)</sup></a>CCREB <a href="#R49"><sup>49)</sup></a>CPKA <a href="#R50"><sup>50)</sup></a>CGluR1 <a href="#R51"><sup>51)</sup></a> ꏊזE̊ɉeƕ񍐂ĂDߔN̊oɂpb`Nv@<a href="#R52"><sup>52)</sup></a> Ca<sup>2+</sup>C[WO@<a href="#R53"><sup>53)</sup></a> ṕCꏊזE̎ˋNɂ^̉ߒԑI𐫂̊mɏdvł邱ƂĂCˋN-VivXʂɂ鉉Ẑ݂ȂD

<h2>7DK}gɒڂH@\̉</h2>
@ԏ񏈗̓IȑʂƂ炦邽߁CIȏɂ̈Ԃ̏`BTAv[`DAv[`̗ƂāCł̓K}gɒڂɂďЉDK}g͊Cn-k玿܂ނ܂܂Ȕ]̈Ŋώ@g30`90 Hz̔]głDj[̊p^[̓K}g̉eC΂΁CK}g̓̈ʑŔ΂悤^C~OŒ肳ĎۂʑŒƂDj[Wcœ̃K}gɈʑŒ肷ƁC~b̐xœ΂ƂȂVivXזEɊ`B₷D̂߁CK}gւ̈ʑŒ͗̈Ԃ̌Iȏ`BɍvƍlĂD
@Cn-k玿ł́CxK}gƑK}g2ނ̎gт̃K}gώ@DCA3쁨CA1ƂoHł͒xK}gCk玿CA1ƂoHł͑K}gCꂼꓯĐCCA1ɂ͂̂̂̃K}gɈʑŒ肷ꏊזȆ݂邱Ƃ񍐂ꂽ<a href="#R54"><sup>54)</sup></a>D܂C2̌oHɂK}g̓ʑŒ͍̋sɉĕω<a href="#R55"><sup>55-58)</sup></a>D̂߁C㗬CA3삨њk玿͂̂̂̃K}g̑ш̐_oāCCA1̏ꏊזE̊_Ci~bNɐ䂷̂ƍlD
@mCK}gւ̈ʑŒ͏ꏊזE̊p^[ɖڂɊ֘AƍlꂽDCʑŒ𐧌䂷זE@\CʑŒƏꏊזE̊Ƃ̋̓IȊ֌W͕sDŕM҂̂ЂƂikj́Cs̃bgCA1삩}`jbgL^sCV̌oɍۂʑŒ̗lԂƁC̍זE@\ƂăVivXY̊֗^ɂĒׂD
@ʓIȖ򗝊wIȎ@邢͈`wIȎ@ɂVivXY̑ł́C]@\sSgɏQ邱ƂD̂߁Cɂ萶_o̕ώCVivXY̑ɂ蒼ړIɐ̂C邢́CSg̕ωɂԐړIɐ̂ʂłȂD̖邽߁CECXxN^[ɂǏIȈ`qςƁC̕ʂ琳mɃ}`jbgL^s@VɊmi<a href="#F4">}4a</a>jD̎@ɂCȔ]ɂāCCA1̋̈ɂVivXYƂ̗̈̐_op^[Ƃ̈ʊ֌W𒲂ׂ邱Ƃ\ɂȂD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@V̊ɂCn-k玿̉H̃f</strong>
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<h2> </h2>
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</ol>
<div class="au-profile">
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<span class="author">k 얁iTakuma Kitanishij</span>
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<strong> BiNaoki Matsuoj</strong>
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</div>
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