Ԃ̔ɂ銲זȆBѕ̐

<strong>ɓ N</strong>
iVK|[Temasek Life Sciences Laboratoryj
emailF<a href="mailto:itot@tll.org.sg">ɓN</a>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
<p>
̈Zr[, <strong>3</strong>, e014 (2014)@<a href="http://dx.doi.org/10.7875/leading.author.3.e014">DOI: 10.7875/leading.author.3.e014</a>
Toshiro Ito: <strong>Growth and differentiation control in <em>Arabidopsis</em> flower development.</strong>

<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/12/Ito-3.e014-PDF.pdf" target="_blank"><img class="size-full wp-image-112 alignright" title="Download PDF" src="/images/downloadPDF.png" alt="Download PDF" width="100" height="20" /></a>
<p>
<p>
<p>
<p>
<p>
<!--more-->

<h2>v </h2>
@Ԃ̊튯`ɂABCf񏥂Ă20N܂肽DVCkiYi𒆐SƂfAɂ`wIȉ͂͂܂Ԃ̔̌́Ĉ̕q`wуQmȊw̐iɂ傫iWĂDANXCBNXCCNẌ`qN[jOC̃R[h]ʈq̏㗬щɂ`qlbg[N炩ɂD̓]ʈq̓QmɂĐ镔ʂɌCS`q̔𐧌䂵ĂDɂ́CBזE̗UCԂ̊튯`␬nɂČƂȂ]ʈqN}`^pNCAz̍CVOi`B^pNȂǂR[h`q܂܂Dꂼ̈`q͉Ԃ̔̎ԎɂēٓIȍזEɂĔ@\ĂDŋ߂̃GsWFleBNX̌ɒڂȂCԂ̊זȆBѕɂ鎞ԓIыԓIɓٓIȐ@\ɂĘ_D

<h2>͂߂</h2>
@qA͐B튯ƂāgԁhCLB̌ʂƂĎq`Dlނ͐SN̗ĵȂŉԂ̎YłqHpɓK邱ƂoCʎ⍒̐Y̌߂̐A|ĂD܂CԂ͂̔䂦CÑlXɈĂDÍ̈ՂǉC͂ȂǂɂāCԂ̊G͕ՓIɂ݂C␶͂̏ےƂDɁCڂ낢䂭lG܁XʂԂ́C{l̖Ɓĝ̂͂h̉lς̏ےłDۂɁCׂĂ̐AɂĉԂ炩Ƃ͊זEƂĂ̊~邱ƂłC͊זE̎ӖDȂΎ̑B~߁C̎q邱ƂɐSԂ̐܂ɁC{l͐̔ƙRdˍ̂ȂD
@̐AȊw̌҂ɂ́Cq`wуQmȊwƂ͂ȃc[ĂDɂCԂ̐藧̊{␶̔̂̂𕪎q̌tœǂ݉Ƃ\ɂȂD̃r[ł́CVCkiYiɂԂ̔̌̂ȂłCƂɉߋ10NԂ̐iCGsWFleBNXזȆB̐@\ɒڂĘ_D

<h2>1DVCkiYiɂԂ̗̔</h2>
@VCkiYiƂfA͉ߋ30NԂɂԈ`wIȌɂđȍvCA̔ɂ鑽̊{𖾂炩ɂĂDA͌sэ̐[ɂ郁XeƂ΂̈ɂĂ˂ɊזEێĂCÂÂ͊זE̐₦ԂȂÂBƕɂĂDh{ɂ́Cs̃Xe͎瑝BC̑ɗts`Ăi<a href="#F1">}1</a>jDC̃VOi邢͓VOi󂷂ƁCs̃Xeɂĉh{琶Bւ̓]NDԐ̗U͂̈`wIȉ͂疾炩ɂꂽCˑoHCtˑoHCIoHCWxˑoĤقCxeoHCoHƂ̓ƗoH̃VOiCŏIIFTCSOC1CAP1CLFYƂԐ𑣐i]ʈq̔U<a href="#R1"><sup>1-8)</sup></a>i<a href="#F2">}2</a>jDB͂܂ƁC܂CtƂȂ̃Xe`Ĉ̂Cԉ肪̊튯ƂČ`i<a href="#F1">}1</a>jDԌɂāCԐU`q̉̋@\ƂĉԊ튯̕̕肷zIeBbN^pN̔U<a href="#R9"><sup>9)</sup></a>i<a href="#F1">}1</a>C<a href="#F2">}2</a>jDzIeBbN^pN͎̂ꂽʒuɂƂÂԊ튯̕UDԂ̊זȄ͔݈̂ێC萔̉Ԋ튯`ꂽ̂̊͗}DזȆB̗}܂zIeBbN^pNɂSĂD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@VCkiYiɂԂ̔</strong>
h{̃Xe͗t`CԐÛɂ͑̃Xeщԉ`DԉɂẮCzIeBbN^pN̑gɂԊ튯̕̕肳D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/12/Ito-3.e014-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2014/12/Ito-3.e014-Fig.1.png&amp;caption=fig1-caption-text]

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@Ԑ𐧌䂷`wIȌoH</strong>
ˑoHCtˑoHCIoHCWxˑoĤقCxeoHCoHVOiCŏIIFTCSOC1CAP1CLFYƂ]ʈq̔UĉԐЂND̏㗬ɂ́CԐ̗}^pNłCIoHCtˑoHCeoH̃VOȉW񂷂FLC@\ĂDFT͉ԐVOi̓^pNłCtŊ󂵂ɂԐUVOisɓ`BԐzitQj̕qIȎ̂ƍlĂDԐ̗}^pNFLCCԐ̑i^pNSOC1CԃXě^pNAP1CԂ̃zIeBbN^pNłAP1CAP3CPICAǴCׂMADShC^pNłD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/12/Ito-3.e014-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2014/12/Ito-3.e014-Fig.2.png&amp;caption=fig2-caption-text]

@炠邢͓VOiĂ͂炭ԐoH́C̓]ʈqуN}`^pNȂ`q̃JXP[hƂė悤ɂȂDVOi̊󂩂Ԋ튯̕̕肷`q̔ɂԂ̂ẤCԎыԓIȔzuɂٓIȈ`q̔lbg[Nɂ炳ƍl邱ƂłDƂɁCԐoHщԊ튯̕̕肷^pNƂẮCMADShC]ʈqvȖ͂Ă<a href="#R9"><sup>9,10)</sup></a>i<a href="#F2">}2</a>jD̓]ʈq͈قȂAɂĂɂ悭ۑĂCԂ̂Â̊{͐AĕۑĂD

<h2>2DԂ̌̕̕ɂzIeBbN^pN̍p@\</h2>
@܂⍂Z̐̋ȏɂfڂĂԂABCf́C1991Nɒ񏥂ꂽ<a href="#R9"><sup>9-11)</sup></a>D֐Ɍ`邪ЁCԕفCYׁCׂ4̉Ԋ튯́̕̕CACBCC3̃NX̃zIeBbN^pN̑gɂ茈肳i<a href="#F1">}1</a>C<a href="#F2">}2</a>jDԂ̌ɂăzIeBbN^pN̋@\ׂďꍇɂ́CԊ튯͗֐Ɍ`镁ʗtɕϊDANXCBNXCCNX̃zIeBbN^pNMADShCƂʂDNAhC]ʈqƂċ@\ĂCɂ́C͂MADShCENX̃^pNKvł<a href="#R12"><sup>12)</sup></a>i<a href="#F2">}2</a>jDȂ킿CЂւ̕ANXAP1ENXSEPƂ̂̕ɂ茈肳Dԕقւ̕̕肷XCb`ƂĂAP1-AP3-PI-SEṔCYׂւ̕̕肷XCb`ƂĂAG-AP3-PI-SEṔCׂւ̕̕肷XCb`ƂĂAG-SEP̂@\<a href="#R13"><sup>13)</sup></a>DMADShC^pN̂́C<em>in vitro</em>ɂĂ͓ʑ̂ƂCArG{bNXƂ΂5f-CC(A/T)<sub>6</sub>GG-3fƂ񕶔zɌDlʑ̂̏ꍇɂDNAɃ[v\̌`U2JCArG{bNXɌ邱ƂĂ<a href="#R14"><sup>14)</sup></a>D
@ԕقւ̕XCb`ƂȂAP1-AP3-PI-SEP̂ƁCYׂւ̕XCb`ƂȂAG-AP3-PI-SEP̂Ƃ̈Ⴂ́CAP1AĜ݂łi<a href="#F2">}2</a>jDÂɂAP1AGƂ̃L^pN𔭌ɂCِ̓MADShC̓DNAƂ̌ɂ͒ڂɂ͊֗^ȂC[CсCIhCɂCɁCC[KhCChCAP1AGƂŌ\łƂĂ<a href="#R15"><sup>15)</sup></a>DȂ킿CԕقƗYׂ̕̕肷XCb`̈Ⴂ́CAP1AGDNAhCC[ɏW񂳂悤łD܂CYׂƎׂ̃̕XCb`̈ႢAP3PI̗LłCِ̓̓^pN̑ݍpɂƂIhCKhCɂ<a href="#R15"><sup>15)</sup></a>D
@<em>in vivo</em>ɂẮCSEP3͓ʑ̂10{ȏ̕qʂł670 kDâ̕`Ă<a href="#R14"><sup>14)</sup></a>DSEP3́CAP3́CAĜɋʂĊ܂܂^pNƂāCSWI/SNF^CṽN}`fO^pNłBRMCISWI^CṽN}`fO^pNłCHR4CCHR11CCHR17CqXgE`yfłREF6肳Ă<a href="#R14"><sup>14)</sup></a>DɁCSEP3̂AĜɋʂ^pNƂāCSWI/SNF^CṽN}`fO^pNłSYD݂ĂD܂CWD40hCTPLAP2ƕ̂`邱ƂmĂ<a href="#R16"><sup>16)</sup></a>DȂ킿CzIeBbN^pN͔ɑ傫ȕ̂`Ĉ̓̕N}`̐ɂ邱ƂDCԂ̔ɂāCQm̓ٓIȕʂɂĎԎɂĂǂ̂悤ȕ̂`Ă邩ɂẮC܂킩ĂȂD

<h2>3DԂ̃zIeBbN^pN̔ы@\</h2>
@zIeBbN^pŃC̕ψقɂ{͋@\זEʂ̃^Cv̍זEɕϊĂ܂߁Cʏ̈`wIȉ͂ł͉̌oH𖾂łȂDx󐫕ψّ́C邢́CXeChzễKhʂƉԂ̃zIeBbN^pNƂ̗Z^pNɂ銈UnCܗU`qv[^[RNAi@ɂỦ\ȋ@\jñgXWFjbNAp邱ƂɂCԂ̃zIeBbN`q͉Ԃ̔̉ߒɂČpIɂ܂܂ȋ@\Ƃ炩ɂꂽDANXCBNXCCNX̃zIeBbN^pŃCꂼ4̉Ԋ튯̌`ԓIɖ炩ɂȂ܂̖ȍזEɂāC\튯̈ɂĂ̔͂܂<a href="#R9"><sup>9)</sup></a>DANX̃zIeBbN^pN͉Ԃ̃Xě̕ɂĂ邽߁CԌ̌`̒ォ甭ĂDCBNXCNX̃zIeBbN^pŃCЂ̌̌`̍ہCԕفCYׁCׂ3̊튯̌̋ʂȂԔXe[W3ɂ<a href="#R17"><sup>17)</sup></a>CꂼCԕفEYח\̈您їYׁEח\̈ɂĔUDCNX̃zIeBbN^pNłAǴCԔXe[W5ԔXe[W6̉ԕقɉ^ÂĂ튯SȗYׂɕϊ邱Ƃł<a href="#R18"><sup>18)</sup></a>DCԔXe[W7ɂȂĂ܂AG̔UĂԕ̌`͗UłȂȂ邪Cԕق̈ꕔ̌`ԂԎ̂悤ɒɂčג邱Ƃ͂łDCזȆB̒~ɂ͉ԔXe[W3AG̊Kvł<a href="#R19"><sup>19)</sup></a>DɁCYׂюׂ̐Ȍ`Ԍ`ɂ́CԔXe[W10ԔXe[W13܂łɂԌpIAG̊KvłƂĂ<a href="#R18"><sup>18,20)</sup></a>DƂɁCԂ̔̒̂RNAi@ɂAG̊mbN_EꍇCׂɂėt̓ł}ꂵgCR[̌`ώ@ꂽ<a href="#R20"><sup>20)</sup></a>DȂ킿CAG͗Yׂюׂ̕Û݂Ȃ炸Ct̃vO}@\ƂꂽD܂CԔXe[W3ԔXe[W4ɂAP3mbN_EƗYׂ玓ׂւ̕ϊN邪CԔXe[W5̂AP3mbN_EĂYׂׂɕϊ邱Ƃ͂ȂnȗYׂ`ꂽ<a href="#R21"><sup>21)</sup></a>DȂ킿CYׂ͉̌̕ԔXe[W3̑Ɍ߂ĂCYׂɉ^ÂꂽԊ튯ׂ͎ɂȂ邱Ƃ͂ȂDŁCԔXe[W7ԔXe[W8ɂAP3mbN_EƉԕق炪Ђւ̕ϊ݂ꂽD̂ƂCԕق̌͐̕B튯xCԂ̔̒܂Ō܂ĂȂƂꂽDȏCԊ튯͉̕ԔXe[WɓٓIɕstIɌ肳CCȋ@\Ԋ튯̌`ɂ̓zIeBbN^pNɂpIȈ`q̔䂪Kvł邱ƂꂽD

<h2>4DԂ̃zIeBbN^pÑ^[QbgƂȂ`q</h2>
@]ʈqƂċ@\zIeBbN^pNۂɂǂꂭ炢̐̂ǂ̂悤ȃ^[Qbg`q𐧌䂵Ă̂Ƃ₢ւ̓́C2000Nォ̃QmȊw̐iWɂ薾炩ɂĂDIȈ`q̗UnpāC}CNAC@RNA-seq@ƂRNAvt@COsƂɂCÛ̎ԎɂIȈ`q̉͂\łDɁCN}`Ɖu~@ƂɂZkꂽz̃Qm^COAC@ɂ͂邢̓nCX[vbgȃV[NGVOɂC]ʈq̌zQmChɉ͂邱Ƃ\łD܂łɁC`qуQmChȌɂƂÂCANXCBNXCCNXCENXׂẴzIeBbN^pNAP1CAP2CAP3-PICAGCSEP3̉̃^[Qbg`q͂Ă<a href="#R20"><sup>20-24)</sup></a>D̃zIeBbN^pNזEɂ锭ʂ͂ق̓]ʈqƔ׍CQmChȌ̉͂ł́CAP3-PI1500CAP1CAP2CAG2000CSEP34000ƁCɂԕʂƌĂD̂C`qƂƂ̓]ʈqƂ̑֊֌W݂ꂽ̂ꂼꐔSقǓ肳ꂽD܂CAP1̃^[QbgƂȂ镔ʂ̔ȏSEP3̌ʂłCۂMADShC^pN̂`ċ@\邱Ƃ^[Qbg`q̉͂ɂĂxꂽ<a href="#R23"><sup>23)</sup></a>D
@ꂼ̃^[Qbg`q͉Ԃ̔̎ԎɂēٓIȍזEɕ̈ɂĔUDƂ΁CCNX̃zIeBbN^pNłAǴCԔXe[W6ɁCCYׂނɂȂזEɂāCʂ̓]ʈqłSPL/NZZ̔U邱Ƃɂԕ̌`U<a href="#R25"><sup>25)</sup></a>D<em>ag</em>ψّ̂ɂ<em>SPL</em>/<em>NZZ</em>`qُ̔IɗU邱ƂɂCԕق̏㕔[ɉԕX̌`UꂽD̊튯͉qAɂĂ݂tIȗYׂ̌`ԂɎĂD܂C<em>ag</em>ψّ̂ɂĈُIȈ`qv[^[p<em>AG</em>`q̔UꍇɂC<em>SPL</em>/<em>NZZ</em>`q͉ԔXe[W5ԔXe[W6̂ꂽԉɂāCނƂȂ̍זEɂĂ̂ݔUꂽD́CSPL/NZZ̗̔Uɂ́CAĜقɔ̎זEɓٓIȃ^pN֗^Ă邱ƂD
@AG͉ԔXe[W10̗ỶׂԎɂDAD1ƂWX_yf̔UCԕ̐nCނ̊JCԎ̐LIɐ䂵Ă<a href="#R18"><sup>18)</sup></a>DDAD1ُ͈IȈ`qv[^[p<em>AG</em>`q̔UƂCnԕقɂĂUꂽD́CłSPL/NZZ̔U邱ƂłȂȂ蕪ԕقɕÂꂽԊ튯ɂĂDAD1̔͗Uꂤ邱ƂDۂɁCԔXe[W7̂AG̔UƂɂ݂Ԏԕق̌`ԂɂłDCSPL/NZZ̔ÛpIAG̊ȂꍇɊώ@ꂽtIȗÝׂCԕ̌`ÛCԎނ̌`ɕKvȃ^pNDAD1̔UȂʂłƉ߂D
@Ԋ튯͗tɗR鑊Ȋ튯łC튯̔z߂`q⌴̌`ɂ`qȂǂ͗tƉԂŋʂĔĂD[ƂɁCtƉԂŋʂɔ錴̌`ɂ<em>JAG</em>`q́CԂɂĂAG̒ڂ̃^[Qbg`qƂĐ䂳Ă<a href="#R20"><sup>20)</sup></a>DANXCBNXCCNẌ`q͉ԉɂĔʂCԂɓٓIȈ`q̗̔Uł͂ȂCtɓٓIȈ`q̗̔}CtƉԂɋʂ`q̉Ԋ튯ɂ锭̗U܂ŁCɑ̈`q̔𐧌䂵ĂDԂ̃zIeBbN^pNƂĂ̋@\Ƃ̐wIȈӖ̒T͂ꂩ̉ۑłŁCꂼ̈`qǂ̂悤ɎԓIыԓIɓٓIȐĂ̂Ƃ₢ւ̒܂C悤₭͂܂ƂłD

<h2>5DԂ̊זEɂ鑝B̗}@\</h2>
@ԂɂẮCזE̋B}Ďq`DԂ̊זȆBѕ̃}X^[`q́CCNẌ`qł<em>AG</em>`qłDAG̊ɂ͊זĚ^pNłWUSړIɋ@\Ă<a href="#R26"><sup>26,27)</sup></a>i<a href="#F3">}3</a>jDWUS̓zIhC]ʈqłČɂ芲זE͈ێȂȂ邽ߎׂȂԂɂȂDWUSLFYȂǂ̓]ʈqƂƂAG̗̔UɒړIɂĂi<a href="#F2">}2</a>jDԔXe[W3ɂAG̔Uꂽ̂ɂCWUS͉Ԃ̊זȆBێÂDWUSAG͖2Ԃɂ킽Ԍ̒Sɂēɋ@\DāC\ȊזȆBȂꂽ2̂ɁCAG<em>WUS</em>`q̔]ʃxŗ}邱Ƃɂ芲זȆBSɒ~i<a href="#F4">}4</a>jD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@Ԃ̊זE𐧌䂷3̓]ʈqƂ̋@\^ψّ̂̕\^</strong>
iajWUSCAGCKNÚCꂼCzIhCCMADShCKhCCWNtBK[hC]ʈqłCזE^pNCU^pNC]ʗ}^pNƂċ@\D
ibj쐶^̉Ԃ́COCЁCԕفCYׁCׂD<em>wus</em>ψّ̂ɂĂ͉Ԋ튯̐C<em>ag</em>ψّ̂<em>knu</em>ψّ̂ɂĂ͉Ԋ튯̐D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/12/Ito-3.e014-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2014/12/Ito-3.e014-Fig.3.png&amp;caption=fig3-caption-text]

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@<em>KNU</em>`q̔̃^C~O͑BƕƂ̃oX̐ɏdvł</strong>
ʏ͉ԔXe[W6ɔ<em>KNU</em>`qɔƁCBƕ̃oXĉԂ̊זE̊ɒ~Ă܂߉Ԋ튯̐DtɁC<em>KNU</em>`q̔xƃXëُȑB̌ʂƂĉԊ튯̐D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/12/Ito-3.e014-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2014/12/Ito-3.e014-Fig.4.png&amp;caption=fig4-caption-text]

@Ԃ̊זE̊}̃^C~O̐ɂẮCAG̒ڂ̃^[Qbg`qł<em>KNU</em>`qdvȖ͂<a href="#R19"><sup>19)</sup></a>DKNU̓WNtBK[WUS̓]ʗ}^pNłCԔXe[W6ɊזȆ݂̈ɂĔUi<a href="#F3">}3</a>C<a href="#F4">}4</a>jDKNU̔̃^C~O͑Bƕ̃oX𒼐ړIɐ䂷̂łC̔ɂԊ튯̐͌CtɁC̒x͉Ԋ튯̐̑ɂȂi<a href="#F4">}4</a>jDȂ킿CKNUWUSAGɂ鎞ԓIɊuĂꂽ̃tB[hobNoH̉݃^pNƂčpD܂CKNȖ̔̓|R[^pNɂ蓱шێqXgCɂ}ĂD

<h2>6DzIeBbN^pNɂqXgC̐</h2>
@]ʈqłAG͉ԔXe[W3ɂĔUꂽ̂CԔXe[W6ɂKNUSPL/NZZ̔U<a href="#R19"><sup>19,25)</sup></a>DԔXe[W6̉ԉɂAG̔UƁCSPL/NZZ͉̔ԕ?̌`̈ɂđɗUDƂ낪CKNU̔AG̔UĂ2̂ɗUDɁCזȆB̗}ɂ͉ԔXe[W3͂܂AG̊KvłCAG̔1点ĉԔXe[W4ɂėUꍇɂ́CKNU̔ʏ1Ċώ@ꂽ<a href="#R19"><sup>19)</sup></a>DȂ킿CɈقȂ̈ɂĔ̗UAG2̒ڂ̃^[Qbg`qł<em>KNU</em>`q<em>SPL</em>`q́CꂼقȂ@\ɂ萧䂳ĂƐ肳DAG<em>KNU</em>`qɒڂɌ̂ɂ炸C̗U2Ԃ̂ꂪ̂͂Ȃ낤D
@AGɂ]ʂ̗U̓|R[^pNr邱Ƃ͂܂i<a href="#F5">}5</a>jD`q}悤ȃqXgC̈ێɕKvȃ|R[^pŇAGɂjQƁCזE̐isɂƂȂ`q̗}Ԃ̊߂NDɂC<em>KNU</em>`q̔2ԂƂԂ̂ƂȂUƂoCI^C}[@\񏥂Ă<a href="#R28"><sup>28)</sup></a>i<a href="#F5">}5</a>jD́C]ʈq|R[^pNrԓIȐזEƘA͂߂Ă̗ƂȂD

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@AGɂזEɈˑIȃqXgC@\̃f</strong>
<em>KNU</em>`q̑̔̓|R[^pNɂ}ĂDAG̔UƁC|R[^pÑN[gɕKvȃ|R[zɋIɌ̊jQDɂCזEɂ鎞Ԃ̂ƂȂ`q̗}Ԃ̊߂ւāC<em>KNU</em>`q̔UD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/12/Ito-3.e014-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2014/12/Ito-3.e014-Fig.5.png&amp;caption=fig5-caption-text]

@|R[^pN͔̉ߒɂāCԓIыԓIɓٓIȈ`q̐ɏdvȖ͂<a href="#R10"><sup>10)</sup></a>D|R[^pN͂قڂׂĂ̍זEɂĔĂ邪CٓIȃQm̈ւ̓Ƃ̔rɂCԓIыԓIɓٓIȈ`q̐䂪炳ĂƍlD|R[^pNN[ĝɕKvȃ|R[z̓VEWEoGɂčŏɓ肳ꂽ<a href="#R29"><sup>29)</sup></a>D<em>KNU</em>`q̏㗬ɂ͂̃|R[z񂪂C̖150 bp̒Zz̓|R[^pN𓱓C`q}悤ȃqXgC~ς邱Ƃɂʂ̈`qv[^[̊}Ƃ@\<a href="#R28"><sup>28)</sup></a>DԂ̔̉ߒɂAG̔Uꂽ̂CAG<em>KNU</em>`q̏㗬̃|R[zɌƁC|R[^pN<em>KNU</em>`qrꌋłȂȂDɂł́C`q}悤ȃqXgCێ邽߂ɁC|R[^pNSDNAtH[Nɂ˂ɌĂ邱ƂĂ<a href="#R30"><sup>30,31)</sup></a>DȂ킿C|R[^pNrƁC`q}悤ȃqXgC͏i<a href="#F5">}5</a>jD܂CqXgC̃_Ci~bNȕωɂ͍זE̐isKvł<a href="#R32"><sup>32)</sup></a>DۂɁC<em>KNU</em>`q̗̔U܂ł̃^C~O͍זE̐isɈˑIł<a href="#R28"><sup>28)</sup></a>DIɂ́CזE̐is𑁂߂邱Ƃɂ11<em>KNU</em>`q̔͗UCtɁCזȆjQɂ2Ԃ̎Ԃ̂͂ɒxꂽDɁClHIȈ`qv[^[\z邱Ƃɂ|R[^pN̔rɂ]ʐnČ邱ƂłD
@VEWEoGɂāC|R[žɂqXgCɂė}Ă^[Qbg`q̔CזE̐isɈˑĒE}邱ƂĂ<a href="#R33"><sup>33,34)</sup></a>DÅזEɂẮCۂɁC]ʈq|R[z̊jQ邱Ƃɂ^[Qbg`q̔E}Ăƍlꂽ<a href="#R28"><sup>28)</sup></a>DAG͉Ԋ튯̕ъזȆB̗}𓝍Iɐ䂵ĂDזȆB̗}זEɂƂÂoCI^C}[ɂ萧䂳Ă̂͂Ȃ낤DQmChȉ͂ɂCAG̉ɂĕ̍זE̐^pN̔䂳Ă邱ƂĂD\̂ЂƂƂāCAG͉Ԋ튯̗̕UƑB̗}̃^C~O̍œK͂邽߁CזEđBƕ߂Ă邱ƂlD܂CɂĂ͖ȊזE͊TṽYȂƂ񍐂<a href="#R35"><sup>35)</sup></a>DԂ̊זE̔̉ߒɂ鎞ԓIȐɂāCזE̐isɂƂȂoCI^C}[@\ɂ͐wIȕKR̂邱Ƃ\zD

<h2></h2>
@ABCf̔\CԂ̌`Ԍ`̕qxł̉͂͑傫WĂD̔wiɂ́Cψّ̂`qN[jOm̕ψّ̂Ƃ̑dψّ̂쐻邱ƂɂCm̈`qƂ̊֘ATĂ`wIȕ@_ɂ܂@\ĂƂDɁCߋ\NԂ̃QmȊwɂƂÂ}CNAC@⎟V[NGT[Ȃǂ̋ZpiɂCANXCBNXCCNX̃^pN̉ɂĂ͂炭^[Qbg`q̑S̑𖾂DɁCƂȂ`q̃C[WO␔wIȉ͂ɂC`wIɓ肳ꂽƂȂ`q\^ɂ܂ł̉ߒ𗝉悤ƂAv[`ɍsĂDȂCẌ`qǂ̂悤ɂĎԓIыԓIɓٓIɐ䂳Ă̂́C܂炩ɂȂĂȂDɁCꂼ̃zIeBbN^pNɂ萧䂳ɑ̈`qCǂ̂悤ɋIɍpĒ@\肾̂ɂĂCقƂǂmłD̃r[ɂĂ̈悤ɁC̐ɂ̓GsWFleBbNȃN}`̐䂪dvȖ͂ĂD܂CAz̒aIȐɂČȂSĂD
@̉ۑƂāCQmChȉ͂ɂĎԎɂԓIȓِ̉𑜓xグĂKvƍlD̂߂ɂ́C܂ł̐wIȉ͂ɗpĂ̋ψꐫグĂƂ̗vłDɂ́C̍זEُɑBψّ̂̊pC̈`q|[^[pZ\[eBOCwWƂ鐸nȂǂ̍Lp҂D܂C͎@ꎩ̂̊xグ邱ƂKvłD̂ȂZpIȐiɂזEɓٓIȉ͂ł悤ɂȂ΁CԎыԓIȔzuɂƂÂcȏ񂪓邾낤DāC𓝍Iɉ͂Ă@KvɂȂĂł낤Dɂ́Cς䂭ɏĕωA̍YC邢́CK͂gݍޕKvDzIeBbN`q3̌`Ԃ̍\zɂ`q̓IȔ̑Sẻ𖾂́C̐AȊw̌҂ɂƂĎgłƂD

<h2> </h2>
<ol>
<li id="R1"><span class='au'>Kobayashi, Y., Kaya, H., Goto, K. et al.</span>: <span class="ti">A pair of related genes with antagonistic roles in mediating flowering signals.</span> <span class='so'>Science, 286, 1960-1962 (1999)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/10583960" target="_blank">PubMed</a>]</span></li>
<li id="R2"><span class='au'>Lee, H., Suh, S. S., Park, E. et al.</span>: <span class="ti">The AGAMOUS-LIKE 20 MADS domain protein integrates floral inductive pathways in <em>Arabidopsis</em>.</span> <span class='so'>Genes Dev., 14, 2366-2376 (2000)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/10995392" target="_blank">PubMed</a>]</span></li>
<li id="R3"><span class='au'>Mandel, M. A., Gustafson-Brown, C., Savidge, B. et al.</span>: <span class="ti">Molecular characterization of the <em>Arabidopsis</em> floral homeotic gene <em>APETALA1</em>.</span> <span class='so'>Nature, 360, 273-277 (1992)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/1359429" target="_blank">PubMed</a>]</span></li>
<li id="R4"><span class='au'>Weigel, D. & Meyerowitz, E. M.</span>: <span class="ti">Activation of floral homeotic genes in <em>Arabidopsis</em>.</span> <span class='so'>Science, 261, 1723-1726 (1993)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17794879" target="_blank">PubMed</a>]</span></li>
<li id="R5"><span class='au'>He, Y. & Amasino, R. M.</span>: <span class="ti">Role of chromatin modification in flowering-time control.</span> <span class='so'>Trends Plant Sci., 10, 30-35 (2005)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15642521" target="_blank">PubMed</a>]</span></li>
<li id="R6"><span class='au'>Gan, E. S., Xu, Y., Wong, J. Y. et al.</span>: <span class="ti">Jumonji demethylases moderate precocious flowering at elevated temperature via regulation of <em>FLC</em> in <em>Arabidopsis</em>.</span> <span class='so'>Nat. Commun., 5, 5098 (2014)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/25267112" target="_blank">PubMed</a>]</span></li>
<li id="R7"><span class='au'>Xu, Y., Wang, Y., Stroud, H. et al.</span>: <span class="ti">A matrix protein silences transposons and repeats through interaction with retinoblastoma-associated proteins.</span> <span class='so'>Curr. Biol., 23, 345-350 (2013)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/23394836" target="_blank">PubMed</a>]</span></li>
<li id="R8"><span class='au'>Xu, Y., Gan, E. S., Zhou, J. et al.</span>: <span class="ti">Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.</span> <span class='so'>Nucleic Acids Res., 42, 10960-10974 (2015)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/25183522" target="_blank">PubMed</a>]</span></li>
<li id="R9"><span class='au'>Ito, T.</span>: <span class="ti">Coordination of flower development by homeotic master regulators.</span> <span class='so'>Curr. Opin. Plant Biol., 14, 53-59 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20869907" target="_blank">PubMed</a>]</span></li>
<li id="R10"><span class='au'>Gan, E. S., Huang, J. & Ito, T.</span>: <span class="ti">Functional roles of histone modification, chromatin remodeling and microRNAs in <em>Arabidopsis</em> flower development.</span> <span class='so'>Int. Rev. Cell Mol. Biol., 305, 115-161 (2013)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/23890381" target="_blank">PubMed</a>]</span></li>
<li id="R11"><span class='au'>Coen, E. S. & Meyerowitz, E. M.</span>: <span class="ti">The war of the whorls: genetic interactions controlling flower development.</span> <span class='so'>Nature, 353, 31-37 (1991)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/1715520" target="_blank">PubMed</a>]</span></li>
<li id="R12"><span class='au'>Pelaz, S., Ditta, G. S., Baumann, E. et al.</span>: <span class="ti">B and C floral organ identity functions require <em>SEPALLATA</em> MADS-box genes.</span> <span class='so'>Nature, 405, 200-203 (2000)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/10821278" target="_blank">PubMed</a>]</span></li>
<li id="R13"><span class='au'>Honma, T. & Goto, K.</span>: <span class="ti">Complexes of MADS-box proteins are sufficient to convert leaves into floral organs.</span> <span class='so'>Nature, 409, 525-529 (2001)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/11206550" target="_blank">PubMed</a>]</span></li>
<li id="R14"><span class='au'>Smaczniak, C., Immink, R. G., Muino, J. M. et al.</span>: <span class="ti">Characterization of MADS-domain transcription factor complexes in <em>Arabidopsis</em> flower development.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 109, 1560-1565 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22238427" target="_blank">PubMed</a>]</span></li>
<li id="R15"><span class='au'>Krizek, B. A. & Meyerowitz, E. M.</span>: <span class="ti">Mapping the protein regions responsible for the functional specificities of the <em>Arabidopsis</em> MADS domain organ-identity proteins.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 93, 4063-4070 (1996)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/8633017" target="_blank">PubMed</a>]</span></li>
<li id="R16"><span class='au'>Krogan, N. T., Hogan, K. & Long, J. A.</span>: <span class="ti">APETALA2 negatively regulates multiple floral organ identity genes in <em>Arabidopsis</em> by recruiting the co-repressor TOPLESS and the histone deacetylase HDA19.</span> <span class='so'>Development, 139, 4180-4190 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/23034631" target="_blank">PubMed</a>]</span></li>
<li id="R17"><span class='au'>Smyth, D. R., Bowman, J. L. & Meyerowitz, E. M.</span>: <span class="ti">Early flower development in <em>Arabidopsis</em>.</span> <span class='so'>Plant Cell, 2, 755-767 (1990)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/2152125" target="_blank">PubMed</a>]</span></li>
<li id="R18"><span class='au'>Ito, T., Ng, K. H., Lim, T. S. et al.</span>: <span class="ti">The homeotic protein AGAMOUS controls late stamen development by regulating a jasmonate biosynthetic gene in <em>Arabidopsis</em>.</span> <span class='so'>Plant Cell, 19, 3516-3529 (2007)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17981996" target="_blank">PubMed</a>]</span></li>
<li id="R19"><span class='au'>Sun, B., Xu, Y., Ng, K. H. et al.</span>: <span class="ti">A timing mechanism for stem cell maintenance and differentiation in the <em>Arabidopsis</em> floral meristem.</span> <span class='so'>Genes Dev., 23, 1791-1804 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/ 19651987" target="_blank">PubMed</a>]</span></li>
<li id="R20"><span class='au'>O'Maoileidigh, D. S., Wuest, S. E., Rae, L. et al.</span>: <span class="ti">Control of reproductive floral organ identity specification in <em>Arabidopsis</em> by the C function regulator AGAMOUS.</span> <span class='so'>Plant Cell, 25, 2482-2503 (2013)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/23821642" target="_blank">PubMed</a>]</span></li>
<li id="R21"><span class='au'>Wuest, S. E., Maoileidigh, D. S. O., Rae, L. et al.</span>: <span class="ti">Molecular basis for the specification of floral organs by APETALA3 and PISTILLATA.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 109, 13452-13457 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22847437" target="_blank">PubMed</a>]</span></li>
<li id="R22"><span class='au'>Kaufmann, K., Muino, J. M., Jauregui, R. et al.</span>: <span class="ti">Target genes of the MADS transcription factor SEPALLATA3: integration of developmental and hormonal pathways in the <em>Arabidopsis</em> flower.</span> <span class='so'>PLoS Biol., 7, e1000090 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19385720" target="_blank">PubMed</a>]</span></li>
<li id="R23"><span class='au'>Kaufmann, K., Wellmer, F., Muino, J. M. et al.</span>: <span class="ti">Orchestration of floral initiation by APETALA1.</span> <span class='so'>Science, 328, 85-89 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20360106" target="_blank">PubMed</a>]</span></li>
<li id="R24"><span class='au'>Yant, L., Mathieu, J., Dinh, T. T. et al.</span>: <span class="ti">Orchestration of the floral transition and floral development in <em>Arabidopsis</em> by the bifunctional transcription factor APETALA2.</span> <span class='so'>Plant Cell, 22, 2156-2170 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20675573" target="_blank">PubMed</a>]</span></li>
<li id="R25"><span class='au'>Ito, T., Wellmer, F., Yu, H. et al.</span>: <span class="ti">The homeotic protein AGAMOUS controls microsporogenesis by regulation of <em>SPOROCYTELESS</em>.</span> <span class='so'>Nature, 430, 356-360 (2004)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15254538" target="_blank">PubMed</a>]</span></li>
<li id="R26"><span class='au'>Lenhard, M., Bohnert, A., Jurgens, G. et al.</span>: <span class="ti">Termination of stem cell maintenance in <em>Arabidopsis</em> floral meristems by interactions between <em>WUSCHEL</em> and <em>AGAMOUS</em>.</span> <span class='so'>Cell, 105, 805-814 (2001)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/11440722" target="_blank">PubMed</a>]</span></li>
<li id="R27"><span class='au'>Lohmann, J. U., Hong, R. L., Hobe, M. et al.</span>: <span class="ti">A molecular link between stem cell regulation and floral patterning in <em>Arabidopsis</em>.</span> <span class='so'>Cell, 105, 793-803 (2001)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/11440721" target="_blank">PubMed</a>]</span></li>
<li id="R28"><span class='au'>Sun, B., Looi, L. S., Guo, S. et al.</span>: <span class="ti">Timing mechanism dependent on cell division is invoked by Polycomb eviction in plant stem cells.</span> <span class='so'>Science, 343, 1248559 (2014)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/24482483" target="_blank">PubMed</a>]</span></li>
<li id="R29"><span class='au'>Muller, J. & Kassis, J. A.</span>: <span class="ti">Polycomb response elements and targeting of Polycomb group proteins in <em>Drosophila</em>.</span> <span class='so'>Curr. Opin. Genet. Dev., 16, 476-484 (2006)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/16914306" target="_blank">PubMed</a>]</span></li>
<li id="R30"><span class='au'>Hansen, K. H., Bracken, A. P., Pasini, D. et al.</span>: <span class="ti">A model for transmission of the H3K27me3 epigenetic mark.</span> <span class='so'>Nat. Cell Biol., 10, 1291-1300 (2008)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/18931660" target="_blank">PubMed</a>]</span></li>
<li id="R31"><span class='au'>Francis, N. J., Follmer, N. E., Simon, M. D. et al.</span>: <span class="ti">Polycomb proteins remain bound to chromatin and DNA during DNA replication <em>in vitro</em>.</span> <span class='so'>Cell, 137, 110-122 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19303136" target="_blank">PubMed</a>]</span></li>
<li id="R32"><span class='au'>Dodd, I. B., Micheelsen, M. A., Sneppen, K. et al.</span>: <span class="ti">Theoretical analysis of epigenetic cell memory by nucleosome modification.</span> <span class='so'>Cell, 129, 813-822 (2007)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17512413" target="_blank">PubMed</a>]</span></li>
<li id="R33"><span class='au'>Busturia, A., Wightman, C. D. & Sakonju, S.</span>: <span class="ti">A silencer is required for maintenance of transcriptional repression throughout <em>Drosophila</em> development.</span> <span class='so'>Development, 124, 4343-4350 (1997)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/9334282" target="_blank">PubMed</a>]</span></li>
<li id="R34"><span class='au'>Sengupta, A. K., Kuhrs, A. & Muller, J.</span>: <span class="ti">General transcriptional silencing by a Polycomb response element in <em>Drosophila</em>.</span> <span class='so'>Development, 131, 1959-1965 (2004)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15056613" target="_blank">PubMed</a>]</span></li>
<li id="R35"><span class='au'>Yagita, K., Horie, K., Koinuma, S. et al.</span>: <span class="ti">Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 107, 3846-3851 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20133594" target="_blank">PubMed</a>]</span></li>
</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">ɓ NiToshiro Itoj</span>
F1997N sww@wȔmے CCN čCalifornia Institute of TechnologyC2003N Senior Research FellowC2005N VK|[Temasek Life Sciences LaboratoryɂPrincipal InvestigatoroāC2011N蓯Senior Principal InvestigatorD
FThings do always work outD
URLF<a href="http://www.tll.org.sg/group-leaders/toshiro-ito/" target="_blank">http://www.tll.org.sg/group-leaders/toshiro-ito/</a>
</div>
? 2014 ɓ N Licensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
