eʃXgXɑ΂זE

<strong>M{YEΐ~</strong>
isww@Ȋw זEwj
emailF<a href="mailto:ytarumot@lif.kyoto-u.ac.jp">M{Y</a>C<a href="mailto:fishikaw@lif.kyoto-u.ac.jp">ΐ~</a>
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̈Zr[, <strong>3</strong>, e004 (2014)@<a href="http://dx.doi.org/10.7875/leading.author.3.e004">DOI: 10.7875/leading.author.3.e004</a>
Yusuke Tarumoto & Fuyuki Ishikawa: <strong>Cellular response to low-dose stress.</strong>

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<h2>v </h2>
@邤ŊωvƂX̃XgXɓK邱Ƃ͏dvłD`q͍̔זẼXgXɂĒSIȖSĂC]ʂ|ȂǑiKɂĖȖȐĂD̂炳XgX̑͒PƂł͖mȕ\^炳Ȃeʂ̃XgXłC̒~ςV₪Ȃǂ̎ɂƎĂDC܂ł̃XgX͍̌זEȂǕ\^̊ώ@̗eՂȍeʂ̃XgXւ̉̉͂SłCeʃXgXւ̉ɂĂ̗͏\ł͂ȂD̃r[ł́CזExɂXgX𒆐SɁCeʃXgXɑ΂鉞ɂ炩ɂȂĂmqׁĈ̂CypeʃXgX̉͂ɊւM҂̌ɂӂD

<h2>͂߂</h2>
@ׂĂ͎̐͂炳܂܂ȏ𓾂ĐĂCxh{Ԃ̕ωȂǊϓvƂXgXĂD̂悤ȃXgXɑ΂vɓK邱Ƃ͐̐q̔ɉhɂėLł邱ƂC͐ỉߒōIȃXgXh@\lBĂƍlD܂ł̌ɂăXgXɂ鑽̃^pN肳C̋@\镡Gȕq@\炩ɂĂD
@̂̃XgX̑́CPƂł͍זEȂǖmȕ\^Ȃ悤Ȓeʂ̃XgXłƍlDƂ΁CDCIȏɑ݂鐶݂͂Ȓeʂ̎OɂXgXђeʂ̊_fɂ_XgXɂ炳ĂD܂CR̊͈ł͂Ȃ˂ɕϓĂ邽߁CXgX̋xނԂƂƂɕϓł낤Dɂ鐶̂߁C͒eʂ̃XgXϓXgXɑ΂h@\{Iȋ@\ƂĔĂƍlD

<h2>1DזẼXgX</h2>
@xCZCpHC_fCh{Ȃǂ̊ω邱Ƃ͍זE̍P퐫ێ邤ōD܂ȂCזEɂƂXgXƂȂD͒PזEɂĂł͂ȂCזÊЂƂ̍זECxɈႢ͂̂̎͂̊̃XgXĂCזExɂK؂ȃXgX͏dvłDXgX̎ނ⋭x邢͐ɂ葽̈Ⴂ͂邪CXgX@\ƂĎvȂ̂`q̔łD
@זEXgXɂ炳ꂽۂɁCɉĈ`q̔N邽߂ɂ͑̏dvȒiKDڍׂ͂ق̑ɂ䂾˂邪<a href="#R1"><sup>1-3)</sup></a>CȉC̊TvqׂD܂CזEO̕ωXgXƂĊmZT[KvłDƂ΁CMVbN^pN͉xωɂϐ^pNoCMXgXЂNZT[ƂȂDXgX̎ނɂ肻F镪q@\͈قȂĂC͍זE邢͍זEɑ݂^pNXgXZT[Ƃċ@\DĈ悤ȃZT[܂炩łȂꍇD
@ŁCZT[̃VOi͊jւƓ`B<a href="#R2"><sup>2)</sup></a>i<a href="#F1">}1</a>jDƂdvȃVOi`BoĤЂƂMAPLi[[̂łCMAPLi[[Li[[Li[[iMAPKKKjCMAPLi[[Li[[iMAPKKjCMAPLi[[iMAPKjƁCyꂩqg܂ł悭ۑꂽ3̃_yfɂVOi`BJXP[hȂDMނ̍זEłp38JNKic-Jun N-terminal kinasej2XgXMAPLi[[ƂĒmĂC܂܂ȃXgX̂ƂŊDMAPLi[[͊jɂē]ʈq_ɂ芈邱ƂŃXgX`q̔UD܂CȊOɂCMAPLi[[̓N}`Ɋ֗^^pNCmRNÄ萫|ɂ^pNȂǁC܂܂ȃ^pN̋@\ƂĈ`q̔Ɋ֗^邱ƂmĂDȂĈ悤ȃXgX̃VOi`B`qߏɋNƍזE̐⑝BɈeyڂ߁C邢͔̗Uꂽ^pNɂ镉̃tB[hobN䂪͂炢ĂD΂₢IƃIt̐؂ւ\ɂ邱ƂɂCזE͕ϓɓK邱ƂłƍlD

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@XgXMAPLi[[ɂ`q̔</strong>
XgXɂ芈ꂽMAPLi[[oH́C]ʂ|Ȃǂ܂܂ȒiKɂ`q̔Ɋ^D
MAPKKKFMAPLi[[Li[[Li[[CMAPKKFMAPLi[[Li[[CMAPKFMAPLi[[D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/04/Ishikawa-3.e004-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2014/04/Ishikawa-3.e004-Fig.1.png&amp;caption=fig1-caption-text]

@yqgȂǂɂĂ̓XgX`q̓]ʂ̓ƂāCnEXL[sO`q⑝BɊ֘A`qƔrāC`qv[^[TATA{bNXC]ʂJnۂɃqXgAZ`yf܂SAGÂɂ鐧䂪dvł邱ƂmĂ<a href="#R1"><sup>1)</sup></a>D܂CVEWEoGɂĂ͔MVbN^pN̂ЂƂHsp70̈`q̗̈ɓ]ʊJn̒̏ԂŒ~RNA|[[Ǎ݂ĂCXgX̍ۂ̓]ʂRNA|[[̐LiKĊJ邱Ƃł΂₢]ʂ\ɂȂĂD̂悤Ȓ~|[[݂͚̑Mނ̍זEɂĂmĂChɑ΂vȍזE\ɂĂƍlĂ<a href="#R2"><sup>2)</sup></a>D
@mRNA]ʂꂽ̂̈`q̔CƂɁC|Jn̒iK̐XgX@\ƂďdvłDT^IȖ|́CmRNA5fLbv\ɖ|Jnq̂łeIF4F̂C3fɃ|A^pNCmRNA[v̍\Ƃ̂CJntRNA܂eIF2̂|ɕKvȂق̃^pN邱ƂɂJnDeIF2͖|JnƂƂɃ{\[痣ꂽ̂CӂъĂ̖|JnɎgpDCזEXgXɂ炳eIF2̃TujbgieIF2j̃_ɂĊjQ邽߁CJntRNA̋ʂčזEŜ̖|Jn}i<a href="#F2">}2a</a>jDeIF2Li[[͕iMނł́CGCN2CPKRCPERKCHRI4jCꂼقȂނ̃XgXɂ芈<a href="#R4"><sup>4)</sup></a>D܂CeIF4F̂Ɋ܂܂eIF4E͌^pNł4EBPɂjQi<a href="#F2">}2a</a>jDh{\ɂƂTorLi[[4EBP}Ă邪Ch{Q̍ۂɂ̗͂}ቺ4EBPeIF4E̋@\jQ邱Ƃɂ|̌͑傫ቺ<a href="#R3"><sup>3)</sup></a>DŁĈ悤ȏɂĂIIɖ|󂳂`q݂i<a href="#F2">}2b</a>jD܂̂́CmRNA5f|̈ɕ̏ORFiuORFj`qłDƂ΁CXgXɏdvȓ]ʈqłoyGCN4MނATF4ȂǂR[hmRNÁCeIF2̃_Nۂɖ|̌㏸<a href="#R4"><sup>4)</sup></a>D܂CIRESiinternal ribosome entry sitejmRNA5fLbv\ɔˑIɖ|󂪊Jnł邱ƂCeIF4EjQꂽꍇł|󂳂<a href="#R3"><sup>3)</sup></a>DɁCXgX̍ۂɔ}CNRNAɂĂ̈`q̖|󂪐䂳D|󂪗}ꂽmRNA͍זEɂăXgX邢P{fBƂ΂\̂`CȂƂ̈ꕔ̓XgXꂽ̂|󂪍ĊJ邱ƂmĂ<a href="#R5"><sup>5)</sup></a>D

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@XgX̍ۂ̖|̐@\</strong>
iaj܂܂ȃXgXɂ|Jn}DeIF2Li[[͊JntRNA̋ɕKveIF2̋@\jQD܂C4EBPmRNA5fLbv\̔FɏdveIF4EjQD
ibjuORFIRES5f|̈Ɋ܂mRNA̖|́CXgX̂Ƃł͑ΓIɑD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/04/Ishikawa-3.e004-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2014/04/Ishikawa-3.e004-Fig.2.png&amp;caption=fig2-caption-text]


<h2>2Deʂ̃XgXɂזE</h2>
@܂ŏqׂXgX@\̑́Ceʂ̃XgXɑ΂Ă@\ƍlDC͂ƂȂhꍇɂ́CזẺm_IȉeꍇDƂ΁CoyɂĒeʂ̐ZXgXۂɂ́CWcɂ͂̃XgXɉĈ`q𔭌זEƉȂזEƂ<a href="#R6"><sup>6)</sup></a>D̂ƂCZXgXɏdvMAPLi[[łHog1iMނp38̃zOj̊̒x̓XgX̋xɔႵđCHog1ɂU`q̔ʂƂ͕KւȂD܂C]ʂ̊ɂ臒l̂邱ƂD̂悤ȓ̉ɂĂ̓N}`\̐䂪dvƍlĂ<a href="#R6"><sup>6)</sup></a>D܂CeʃXgX邢͍eʃXgXɂ菈oymRNAу^pN̗ʂԗIɒׂʂł́CeʃXgXƂɂ͑mRNAу^pN̔ʂϓĈ̂̈`qɂmRNA̕ϓƃ^pN̕ϓƂ͑ւCeʃXgXƂɂmRNA̕ϓƃ^pN̕ϓƂ͕KւȂ<a href="#R7"><sup>7)</sup></a>DɁCeʃXgXɉۂ̍זẼ^pN̕ϓɂéC]ʂɂ̂|ɂ̂̂ق傫ƂĂDCył͎_XgX̋xɉĈقȂ]ʈqɂ`q̔SIȖSƂmĂ<a href="#R8"><sup>8)</sup></a>D̕񍐂́CXgX̋xɂقȂ镪q@\邢͈قȂ鐧@\ň`q̔䂳Ă邱ƂĂCזẼXgX̑Se𖾂炩ɂ邽߂ɂ͒eʃXgXɑ΂鉞ɒڂKvł邱ƂĂD

<h2>3DeʃXgXɂlϐьϐ</h2>
@XgXɑ΂K̂ЂƂɁCזEeʂ̃XgXivC~OXgXjɂ炷ƁĈ̂ɂ炳鍂eʂ̃XgXi2XgXjɑ΂RlƂۂmĂi<a href="#F3">}3</a>jĎۂ͊lϐiacquired tolerancejƂ΂ĂCזẼxɂ炸̂̃xɂĂ܂܂Ȑɂĕ񍐂ĂD̃XgXɑ΂R̊l͈ߓIȌۂłCvC~OXgX̂x̎Ԃo߂Ɗώ@ȂȂD܂CXgXɂϐψّ̂邱Ƃł͐ȂD܂Ĉ悤ȒR̓vC~OXgXƂ͈قȂނ2XgXɑ΂ĂlCϐicross-tolerance邢cross protectionjƂԁDϐ͉w\p@̗ގŵőώ@錻ۂł邪CxωƐZXgX̂悤ɂ܂֌WȂƎvXgX̂łN肤D

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@eʃXgXɂlϐ</strong>
iajeʃXgXɂ炳ꂽזÉCזEЂN葝B邵肷D
ibjeʃXgXɂ炳ꂽזEɂ́Cmȕ\^ώ@ȂD
icjeʃXgXivC~OXgXjɂ炳ꂽזÉCɂÂeʃXgXi2XgXjɑ΂RlC㏸ilϐjD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/04/Ishikawa-3.e004-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2014/04/Ishikawa-3.e004-Fig.3.png&amp;caption=fig3-caption-text]

@z~VXihormesisC臉iʁjƂ́CZx邢͑ʂɗpƗLQł镨iŕjCZx邢͔ʂŗpƋtɗLvɍpƂCpʔւۂ̂Ƃ<a href="#R9"><sup>9)</sup></a>DƂ΁C̐ɕKvȎ_f͍Zxł͔x̏QȂǈeyڂCC⍂Zx̎_f̓X|[cÎ̎ÂɗpȂǗLvȑʂ킹ĂiCׂĂ̂̕悤ȗpʔւ킯ł͂ȂjD݂͂܂c_̗]n傫Cz~VXʂƍR񂠂邢͍RVƂ̊֘A悤ȕ񍐂Dɏqׂlϐьϐ̓z~VXʂ̈ƂƂ炦邱ƂłD
@lϐ邢͌ϐ̕q@\ɂĂ͕sȓ_CvC~OXgX̍ۂɃ^pNjQ邱ƂɂR̊l}邱ƂCvC~OXgX̍ۂɔ̗U`qYɂʂ傫ƍlD܂܂ȃXgX̂ƂŋʂĔ̗U`q݂̑}CNAC͂ɂ薾炩ɂĂCoyłESRienvironmental stress responsejCyłCESRicore environmental stress responsejƂ΂CꂼꐔS̈`q܂܂Ă<a href="#R10"><sup>10,11)</sup></a>D܂܂ȃXgXɉĔ̏㏸`q̐͐ɂقȂCoyɋ߂łJW_ǂ̌ł<em>Candida albicans</em>ł͔ɏȂ<a href="#R1"><sup>1)</sup></a>D܂CMނ̍זEɂĂ̈`q݂̂̃XgXɂ苤ʂĔ̏㏸邱Ƃ񍐂ĂC͍זEɂĂقȂ<a href="#R2"><sup>2)</sup></a>D
@lϐ邢͌ϐώ@XgX͐ɂقȂDƂ΁Coył̓vC~OXgXMXgXC2XgX_XgXƂꍇɌϐN邪Ct̑gł͋NȂ<a href="#R12"><sup>12)</sup></a>DCył͂ǂ̑głϐUC2XgXɑ΂鐶㏸<a href="#R13"><sup>13)</sup></a>DESRCESR\`qɂ͑lȐ@\^pNR[hĂ邪CKOɏXgXւ̉ɕK{łȂ̂܂܂ĂC͏IɑƊ҂XgXɑ΂h@\ɂȂƂf񏥂Ă<a href="#R12"><sup>12)</sup></a>Doył݂悤ȉ̔Ώ̐͂ق̐łώ@ĂC̐邢͍זEĂɂƂKŐiĂʂƍl<a href="#R14"><sup>14)</sup></a>D

<h2>4DϐwWƂeʃXgXɊ֘A^pN̒T</h2>
@זEɒeʂ̃XgXPƂŏꍇɂ́CזEȂǔʂ̗eՂȕ\^͊ώ@łȂD̂߁C]̌ł͍eʂ̃XgXזEɏꍇɊώ@\^wWƂăXgXɊ֗^^pNTĂDC̏ł͒eʃXgXɑ΂鉞ɂĂƂɏdvȋ@\^pŃCĂeʃXgXɑ΂鉞̍ۂ̕\^ɂ͂قƂǉeȂ߁C̑Ώۂ珜OĂ܂Ƃ\zD
@ɏqׂlϐϐ͘AăXgXɂ炳ۂ̌ۂłCϓɂXgX̌̂ꂽfɂȂDɁČۂɂזE̒R̊ĺCvC~OXgXɑ΂זẺ𔽉fĂƍlD܂Clϐ邢͌ϐwWƂ邱ƂɂCPƂł͕\^̊ώ@ɂeʃXgXɑ΂鉞Ĉ̂ɂ鍂eʃXgXɑ΂鉞ԐړIɔfł邱ƂӖD̂ƂCK؂ȋx2XgXp邱ƂɂCזE̐wWƂĊlϐ邢͌ϐ̗LʓIɊώ@邱ƂłDeʃXgXɕKvȃ^pNُ̈ɂϐɌƂ\z邱ƂCM҂́CeʃXgXɂ^pN𓯒肷邽߁CyɂČϐɌזË`wIȃXN[jOsĎʁČϐĂCȉČ`qYƂē肳ꂽ2̃^pN̋@\ɂďڍׂɏqׂD

<h2>5DHIR/HIRAɂXgX̐</h2>
@yɂČϐ̌`qƂēꂽ<em>slm9</em><sup>+</sup>`q́CoyHIR邢͚MHIRÃzOłSlm9R[h<a href="#R13"><sup>13)</sup></a>DHIR/HIRÂ͕Ƃċ@\ĂCoyłHir1CHir2CHir3CHpc2CyłHip1CSlm9CHip3CHip4CMނłHIRACCabin1CUbinucleiniUBN1UBN2j炻ꂼ\Ăi<a href="#F4">}4a</a>jDHIR/HIRA͎vȃqXgH3-H4VŷЂƂłCDNAɔˑIɃkNI\[DNAɔzûɏdvł<a href="#R15"><sup>15)</sup></a>DCق̃qXgH3-H4VyłCAF-1DNAuɊ܂܂PCNAƌCDNAɐVKɍDNAɃkNI\[zuDqXgH3ɂ͂̃oAg݂邪ĈȂŃqgHIRA̓qXgH3.3ƁCCAF-1̓qXgH3.1уqXgH3.2ƑIIɌDqXgH3.3܂ރkNI\[DNAɂ铮̎RxƂCق̃qXgH3oAg܂ރkNI\[Ƃ͋@\IɈقȂƍlD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@HIR/HIRAɂN}`̐@\</strong>
iajHIR/HIRÂ̍\^pND
ibjHIR/HIRAɂ`q̐@\D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/04/Ishikawa-3.e004-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2014/04/Ishikawa-3.e004-Fig.4.png&amp;caption=fig4-caption-text]

@HIR/HIRA͈`q̔ɂ[Ăi<a href="#F4">}4b</a>jDoyHIRDNAȊOɂqXg̈`q̓]ʂ}^pNƂē肳ꂽD̂̂CHIR̓weN}`̌`шێC`q̋ߖT̐ݓIȁicrypticj`qv[^[̓]ʂ̗}ɏdvł邱Ƃ炩ɂȂCL͈͂ɂē]ʐɂĂ<a href="#R15"><sup>15)</sup></a>DyɂĂCweN}`̌`CggX|]̔}CA`ZX]ʎY̔}Ȃǂɋ@\D܂CMނ̍זEł͍זEVɓٓIȃweN}`\łSAHFisenescence-associated heterochromatic fociǰ`ɏdvłDɂ킦āCHIR/HIRA͓]ʂ𐳂ɐ䂷@\DۂɁCMނ̍זEɂăqXgH3.3܂ރkNI\[́C]ʂ̗}Ă`q̈悾łȂC]ʂ̊Ă`q̈ɂώ@Dؕ肷<em>MyoD</em>`q̔ɂHIRAɂ`qv[^[̈ւ̃qXgH3.3̔zudvł邱ƂĂCHIRA]ʂ𐳂ɐ䂵ĂłD܂CoyꂨњMނ̍זEɂāCRNA|[[`q̈ʉ߂̂̃kNI\[̍č\HIR/HIRAĂƂ̕񍐂CHIR/HIRA͓]ʐL̒iKɂN}`\̈ێɏdvƂf<a href="#R15"><sup>15)</sup></a>D
@M҂̌ɂ<a href="#R13"><sup>13)</sup></a>Cyɂ<em>hip1</em><sup>+</sup>`qC<em>hip3</em><sup>+</sup>`qC<em>hip4</em><sup>+</sup>`qꂼ`qj󂷂<em>slm9</em>j󊔂ƓlɌϐɌƂCHIRÂƂĂ̋@\ϐɂďdvłƍlꂽDHIRÂ̍\^pNR[h<em>slm9</em><sup>+</sup>`qC<em>hip1</em><sup>+</sup>`qC<em>hip3</em><sup>+</sup>`qC<em>hip4</em><sup>+</sup>`q̔j󊔂ƁCXgXMAPLi[[R[h<em>spc1</em><sup>+</sup>`qiMނ<em>p38</em>`q̃zOj̔j󊔂ɑ΂āCeʂ邢͍eʂ̔MXgX_XgXƁC<em>spc1</em>j󊔂͂ǂ̏ɂĂ󐫂̂ɑ΂C<em>slm9</em>j󊔂Ȃǂ͒eʃXgXɑ΂Ă̂݋󐫂ƂCyHIRÂ͒eʃXgXɉۂɂdvł邱ƂꂽD̂Ƃ́CϐwWƂXN[jOneʃXgXɂ^pN̓ɗLł邱ƂxD
@yHIRÂXgXɋ@\镪q@\邽߁C쐶^<em>slm9</em>j󊔂邢<em>hip1</em>j󊔂̃XgX̍ۂ̈`qp^[}CNACɂ͂C̊Ŕʂɍ`q̓`qIgW[ڂɂrƂCgcellular response to stresshCgcellular response to stimulushȂǂ̃XgXɂ`qIgW[ڂLӂɔZkꂽiȂC쐶^ƔׁCHIRÂ̍\^pNR[h`q̔j󊔂ł̓XgXɂ`q̔ϓ͏jD܂CHIRÂ̓XgX`q̔ɂďdvȖƂꂽD܂CXgXזEɂāCXgX`qORFт̈`qv[^[̋ߖT̗̈ւHIRA̋Ǎ݂N}`Ɖu~ɂmFꂽDXgX`q̔ɏdvȓ]ʈqAtf1זEł̗͂̈ւHIRǍ݂ȂȂ߁CHIRÃN}`ւ̋Ǎ݂̓XgXhɂ萧䂳Ă邱ƂꂽDɁC<em>slm9</em>j󊔂ł̓XgX`q̗̈ɌRNA|[[̗ʂƂCyHIRA͓]ʂ̊ɋ@\邱ƂÂꂽD`q5f̗̈ɂ̓kNI\[KzuĂ邱ƂmĂC`qۂɂ͂̎ӂ̃kNI\[̗ʂDɂgJhDNA\`C]ʂɕKvȃ^pNDNAɍp₷ȂƍlĂD<em>slm9</em>j󊔂ł͂̂悤ȃkNI\[̉𗣂NȂȂĂƂCyHIRA̓vC~OXgXɉăkNI\[ĕҐC]ʊJn̂RNA|[[`qv[^[̋ߖTɌĂэ݃XgX`q̔𑣐i邱ƂɂCϐɊ^Ăƍl<a href="#R13"><sup>13)</sup></a>i<a href="#F5">}5</a>jD

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@ySlm9Cpc2ɂXgX̐@\ɂė\z郂f</strong>
Slm9iHIRAj̓kNI\[\̐ɂXgX`q̔𑣐iDCpc2̓XgXMAPLi[[łSpc1ɂ]ʐƁCeIF2Li[[łGcn2|󐧌Ɋ֗^D
PF_D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2014/04/Ishikawa-3.e004-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2014/04/Ishikawa-3.e004-Fig.5.png&amp;caption=fig5-caption-text]

@MXgXoyɂRNA|[[܂ފ{]ʈq̂̃QmChȋǍ݂̉͂ł́CׂĂ̍\^pN̂]ʊJn̂łȂC̈ꕔ]ʊJn̂̌XgẌ`qv[^[݂̑Ă<a href="#R16"><sup>16)</sup></a>D͂ÂĎ_XgX邱Ƃɂ芮Sȓ]ʊJn̂ւƕωƂĈ悤ȕsSɍ\zꂽ]ʊJn̂́Ĉɂ炳\̂XgXɍזE΂₭邽߂̒ԏԂƂċ@\ƂfĂĂĎۂق̃XgX␶ɂʉł邩ǂ͕sł邪CHIR/HIRÂɂkNI\[̍ĕҐC]ʂɕKvȃ^pNDNAւ̌𑣐iCvɓ]ʉ̗UłicompetentjԂ̃N}`\`Ă\lD

<h2>6DRACK1/Cpc2ɂXgX̐</h2>
@M҂̃XN[jOɂ蓾ꂽy̌ϐ̂C̍זĚ`qƂē肳ꂽ̂<em>cpc2</em><sup>+</sup>`qłi\jD^jɂčyꂩqg܂ł悭ۑꂽ^pNR[hĂCMނȂǂ̍^jł͊veCLi[[Cƌ^pNƂē肳ꂽƂRACK1ireceptor for activated C-kinasejƖÂĂDGNB2L1iguanine nucleotide-binding protein subunit beta-2-like-1jƂʖCOʑG^pÑTujbgƍDgvgt@ciWjƃAXpM_ciDjƂ̓IȔzuȂ40A~m_cWDs[giWD40s[gj7C炪vy\ƂĂ<a href="#R17"><sup>17)</sup></a>DWDs[g̓^pNԑݍphCƂĒmĂCSH2hCPHhCCveCLi[[ĈC2hCȂǁCق̃^pNԑݍphCƌ邱ƂłDWDs[g܂ރ^pN͍זEɑC100ވȏ݂ĂiHIRAWDs[gjDRACK1͍yf悤ȃhCȂ߁C̋@\͂ق̃^pNƕ̂`邱Ƃɂ蔭ƍlD܂łɁCveCLi[[C̃AC\tH[ɂ킦C̃^pNRACK1zOƑݍp邱Ƃ񍐂ĂDזEɂĂ܂܂ȋ@\^pNƕ̂`邱ƂɂCRACK1zO̊֗^זÉCCBCA|g[VXC^邢͋ɐCƉuȂǑɂ킽CƂ΁CveCLi[[CCMAPLi[[CSrcȂǂƂLi[[ƌĂ̊㏸邢͗}CLi[[̊ق̃^pNƂ̌𑣐iCVOi`B̃NXg[N𑣐iCƂ@\D܂CRACK1CeOêCXlqIêȂǂ̖ђʌ^êẽ`VLi[[ƌC̎͂ɃVOi`B̂̌`𑣐i񍐂ĂD̂悤ɁCRACK1zÕ͕^pNƓɌC̔̑iscaffoldj邢̓nuƂċ@\邱ƂɂזEŋN锽ԓIɐ䂷@\Ǝ<a href="#R17"><sup>17)</sup></a>D
@ŁCRACK1̓{\[̍\^pNłDRACK1܂ރ{\[̂̌\͂CRACK140S{\[TujbgɂmRNȀoƂȂgl̋ߖTɌ邱Ƃ炩ɂĂ<a href="#R18"><sup>18)</sup></a>DXN[XxzS@ɂזEot̕悩CזȆ啔RACK1̓{\[ɌĂƍlD{\[ɌRACK1zO̖|󐧌ւ̊֗^ɂāC܂łɑ̕񍐂ȂĂ<a href="#R18"><sup>18,19)</sup></a>DƂ΁CMނRACK1̓veCLi[[CIIɂ|JnqeIF6̃_ɏdvłD̃_eIF660S{\[Tujbg𗣂邱Ƃɂ80S{\[̂̌`𑣐iD܂CoyRACK1̃zOłAsc1͖|JnqeIF3c/NIP1ƌ邱Ƃɂ|Jn̂{\[ւƌĂэނ̂ɋ@\D̂悤ɁCS̓Iȃ^pN̑iɂ킦CoyłAsc1RNA^pNScp160{\[֌ĂэނƂɂ̃^pN̖|𘴐i邱ƂĂDCqgłRACK1zO}CNRNAɈˑIȖ|}ɋ@\邱ƂĂD|̌̐䂾ł͂ȂCVKɍꂽ^pN̕iǗɂĂRACK1zO̊֗^񍐂ĂCRACK1zO|󐧌ɂ͂@\͑lłD
@yCpc2ϐɋ@\镪q@\͂܂炩ł͂ȂCRACK1zO̓XgX̍ۂɂdvȖSƂ͂񍐂ĂDMނRACK1̓veCLi[[CJNKƌCOƎ˂Ƃ̃veCLi[[CɂJNK̃_ij𑣐i<a href="#R20"><sup>20)</sup></a>DRACK1̔}m[}זEł́CȌƎ˂ɂA|g[VX̑Ck[h}EXֈڐAƂ̎ᇌ`\̒ቺώ@DCX̏Ǝ˂Ȃǂ̃XgXɂẮCRACK1MAPLi[[Li[[Li[[̂ЂƂłMTK1ƌXgXMAPLi[[oH̊ɂA|g[VX𘴐i邱Ƃ񍐂Ă<a href="#R21"><sup>21)</sup></a>CזEXgX̎ނɂRACK1͈قȂ镪q@\SDC̏ꍇɂĂRACK1̓VOi`B𑣐i邱ƂɂXgXɊ^ĂDʓIɁCeʃXgXɑ΂זEƔrāCeʃXgXړIɊ镪q̐͏ȂC̊̒x͒ႢƂ\zD̂悤ȔȉɂVOi`B̍ۂɂ͑^pN̂悤ɔ𑣐i^pN̏dv傫ȂƍlCRACK1̒eʃXgX̍ۂ̋@\̓VOi`B̊̂߂臒lቺ邱ƂɂƍlD
@yɂĂC<em>cpc2</em>ɂĂ͍זEAtf1̗ʂ邱Ƃ񍐂Ă<a href="#R22"><sup>22)</sup></a>CCpc2XgXMAPLi[[oH̐Ɋ֗^邱ƂDyɂăXgXMAPLi[[oH͂ɏqׂCESR̔UC܂܂ȃXgXɑΉÃXgX`q̔㏸邱ƂCϐɏdvłDCpc2͂̃VOi`BoH̊𑣐i邱ƂɂזE̒eʃXgXɊ^ƂflDЂƂ̉ƂāCeʃXgX̍ۂ̈`qp^[̕ω͖|󐧌ɂ̂̊傫ƂlƁCCpc2XgX̍ۂ̖|󐧌ƂČϐɊ^Ă邱ƂlDۂɕM҂̌ɂCyCpc2A~m_QXgX̍ۂeIF2Li[[łGcn2̊𑣐i邱ƂCeIF2̃_|󐧌ɂďdvł邱Ƃ炩ɂȂĂ<a href="#R23"><sup>23)</sup></a>D݂̉͌ɖ̂ł͂ȂCCpc2̌oHɂeʃXgXɊ^Ă\li<a href="#F5">}5</a>jD

<h2></h2>
@eʃXgXɑ΂oÿ`qƂȂ錻ۂ́CזEWcƂĉ͂C1זẼxň`q͂Ƃɂ薾炩ɂȂ<a href="#R6"><sup>6)</sup></a>Dm_IȔ̉e傫Ȃ悤Ȏアhɑ΂鉞𖾂炩ɂĂ߂ɂ́C1זÊȂŋNĂ锽ώ@邱Ƃ̏dv͍D]͎̉@ɂ킦Ĉ悤1זExł͎̉@gݍ킹邱ƂɂC܂ŒmĂȂXgX̕q@\̖炩ɂȂ邱Ƃ҂D
@XgX@\̔j]CV܂ނ܂܂ȎƖڂɂ邱Ƃ͂łɒmĂ<a href="#R24"><sup>24)</sup></a>Cpx̍eʃXgXɑ΂זE̎ӂ̂ɏdvȖSĂ邱Ƃ͑zɂȂD܂CỉߒɂĐωɂXgXɑ΂ǂ̂悤ɓKĐĂ̂𗝉邤łC萶Iłeʂ̃XgXɑ΂זE̕q@\̉𖾂dvłD

<h2> </h2>
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<li id="R13"><span class='au'>Chujo, M., Tarumoto, Y., Miyatake, K. et al.</span>: <span class="ti">HIRA, a conserved histone chaperone, plays an essential role in low-dose stress response via transcriptional stimulation in fission yeast.</span> <span class='so'>J. Biol. Chem., 287, 23440-23450 (2012)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22589550" target="_blank">PubMed</a>]
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</ol>
<div class="au-profile">
<h2>҃vtB[</h2>
<span class="author">M{ YiYusuke Tarumotoj</span>
F2009N sww@ȊwȔmے CCN蓯 D
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<strong>ΐ ~؁iFuyuki Ishikawaj</strong>
sww@Ȋw D
URLF<a href="http://www.lif.kyoto-u.ac.jp/labs/fish/" target="_blank">http://www.lif.kyoto-u.ac.jp/labs/fish/</a>
</div>
? 2014 M{YEΐ~ Licensed under <a href="http://creativecommons.org/licenses/by/2.1/jp/" target="_blank">CC \ 2.1 {</a>
