ɑ΂LRe̔TזEÖ@̍őO

<strong>ې B</strong>
iww@wn זEwuj
emailF<a href="mailto:hnaoki@imed3.med.oska-u.ac.jp">ې咼B</a>
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̈Zr[, <strong>6</strong>, e005 (2017)@<a href="http://dx.doi.org/10.7875/leading.author.6.e005">DOI: 10.7875/leading.author.6.e005</a>
Naoki Hosen: <strong>Recent advances in chimeric antigen receptor T cell therapy against cancer.</strong>

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<h2>v </h2>
@M҂́C񊲍זE̍R̓CāCɑ΂郂mN[iR̗Ö@̊J傫ȖڕWƂČĂDߔNCmN[iR̂pVȂƉuÖ@ƂĒڂĂ̂CLRe̔TזEɂ鎡Ö@łDLRe̔TזÉCɓٓIȍR̂̍RFʁC⏕héCCD3čZč쐻LRêTזEɔ̂łDLRe̔TזE͂ɓٓIȍRFĊCזEQ݂̂Ȃ炸C̓ɂđʂɑBD܂CRِ̈̍ƁCזEÖ@̋זEQёB킹ɋ͂ȎÖ@łDłCD19WIƂLRe̔TזE͗ՏɂĂ̗L\ɎĂCpɂĂDC܂܂Ȃɑ΂鎡Ö@̂ЂƂɂȂ肤ƍlC͓IɌi߂ĂD

<h2>͂߂</h2>
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<h2>1D񊲍זEWIƂR̗Ö@̊JLRe̔TזE</h2>
@񊲍זEƂ́CȊזEƓlɎȕ\Ɓij\Ƃ킹זEłD񊲍זEƂTO͌Â瑶݂ĂC1990N㔼Έȍ~CƉusS}EXpَڐAn̐iɂƂȂ̑ΏۂёnɂWIƂȂi<a href="#F1">}1</a>jD1997NC}aɂāCƉusS}EXɐač\z锒åזEȑזEƓCD34zCD38A敪ɑ݂ƕ񍐂ꂽ<a href="#R1"><sup>1)</sup></a>D܂CCD34zCD38A̔åזE}ǎłCrȂ蔒a͎Ȃƍl悤ɂȂāĈ̂C܂܂ȂɂĂƂ񊲍זE肳ꂽDŌ`̂񊲍זEƉusS}EXւ̐ɂ`邱ƂɂĂ͂܂̋c_C̈Ӌ`͒܂ĂȂC̍߂߂̊TOƂĂ񊲍זEWIƂÖ@Jׂł邱Ƃ͋^܂łȂD

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iaj̍R܂͂قƂǂ̂ɂč炷Ƃ͂łȂD񎡗ÂtĂ悤ɂ݂ĂC񊲍זEcĔ߂łD
ibj̊̂߂ɂ͂񊲍זEWIƂVÖ@KvłD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/07/Hosen-6.e005-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2017/07/Hosen-6.e005-Fig.1.png&amp;caption=fig1-caption-text]

@̎ÖɂrłȂ񊲍זE₷邽߂̐헪ƂāCR̗Ö@͂߂ėL]łi<a href="#F2">}2</a>jDہCRCD20ŔicLV}uj͂߂Ƃ郂mN[iR͈̂̌t̎̌ɑ傫vDaזEɑ΂WIR̓͂ɐi߂CCD47CTim3 <a href="#R2"><sup>2)</sup></a>CM-CSFR <a href="#R3"><sup>3)</sup></a>CCLL-1CCD123CCD44Ȃǂ܂܂Ȍ₪āCpɂނJiłDM҂CCD96åזEɓٓIȍRł邱Ƃo<a href="#R4"><sup>4)</sup></a>D

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@񊲍זE̍R̓肨тWIƂmN[iR̗Ö@̊J</strong>
R̗Ö@͊̍R܂ƈقȂC܂蕪􂵂ĂȂ񊲍זEɑ΂Ăʂ\zD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/07/Hosen-6.e005-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2017/07/Hosen-6.e005-Fig.2.png&amp;caption=fig2-caption-text]

@ЂÂāCM҂́Cɂ邪񊲍זĚJnCƉusS}EXɂčč\z\͂זȆOזE͍`זÊȂɑ݂邱Ƃ𖾂炩ɂDCȑO񍐂Ă悤ɁCCD19zBזẺ敪ɂ͍זȆOזEƂȂזE݂邱ƂmłDŁCCD19zBזEэ`זÊׂĂƌr悤ȍR̂쐻ł΍N[̔rBƍlC̊҂ɗR鍜̌̂pĂ̂悤ȕWITĎʁCCD19zBזEэ`זÊقڂׂĂɍ邪CCD34zCD38ȂזEɂ͂܂ȂזE\ʍRƂCD48oꂽDCD48̔x͍זE110<sup>5</sup>̃I[_[ƔɍCCD20CD52ɕCGR̂Ɉˑ̍זE̍זEQ̂Ɉˑ̍זEQЂNɂ͏\łDRqgCD48mN[iR̂쐻ĈIgG2aAC\^CvN[1B4pĈَڐAfɂčRƂCɍ}ʂؖꂽD݁CՏpi߂D
@̂̂C肪ɑ΂ِ̍RƂ߂ČÂD̓Iɂ́CזEɓٓIȖ|C邢͗̍\FR̂TĎʁCL]ȍRɓD́CɓٓIł_͂悢CזEɂR̖xقǍȂƂ_łD̓CoꂵĂ̂LRe̔TזEłDLRe̔TזEp΍R̖x̒Ⴂ̂WIƂ邱Ƃ\ŁC݁CLRe̔TזEp̎Ö@̊Jɗ͂łD

<h2>2DLRe̔TזEÖ@̌</h2>
@LRe̔TזEÖ@́CCD19WIƂLRe̔TזẼpaɑ΂ٓIȌʂ񍐂Ĉȍ~CEŒڂтĂVƉuÖ@łDɓٓIȍRɑ΂郂mN[iR̂΁C̍RFʂ`qN[jOC⏕hêCD3čƂ̗Z^pNƂăLRê쐻邱Ƃ\łDTזEɓ̂LRe̔TזEŁCɓٓIȍRF邱Ƃɂ芈CזEQi<a href="#F3">}3</a>jD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@LRe̔TזEÖ@Ƃ</strong>
iajLRe̔TזEÖ@̌D
ibjۂ̗Տp̗D
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/07/Hosen-6.e005-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2017/07/Hosen-6.e005-Fig.3.png&amp;caption=fig3-caption-text]

@BזEɗR錌tɑ΂CD19WIƂLRe̔TזEÂ̗ՏɂĔɍS𗦂񍐂<a href="#R5"><sup>5-7)</sup></a>C2017Nɂ́CčHiiǂɂ鏳F݂܂ĂD̍L̗ԂƂĕpx̍LQۂOĂCxÖ@̔BȂǂɂSɎ{s̉\ȎÖ@ɂȂD܂̂ƂCt݂̂łL͔F߂ĂȂCCŌ`ւ̉piނƈCɂ񎡗Ö@̃CXg[ɂȂ\D
@LRe̔TזEÖ@̊vVIȓ_́CזEÂɗp_łDR̂ᕪqƂ͈قȂCTזE͊҂̑̓ɂĔIɑB邱Ƃł邽߁C܂܂ł̈iɂ݂͂Ȃ悤Ȕj͂Â\ɂȂDŁC̈З͂K؂ɐ䂷邱ƂۑɂȂDCD19͂񉻂BזEłȂBזEɂDɂ炸CCD19WIƂLRe̔TזEÖ@͉\łDȂȂCBזȆrɂƉusŚCƉuOuʂɓ^邱Ƃɂ␳ꂤ邩łD
@̐ɂ炸CCD19WIƂLRe̔TזEÖ@ɂ͂̖肪cĂDpx̍dĂȗLQۂƂĂ̓TCgJCoǌQѐ_oǏ󂪂DTCgJCoǌQ͂΃LRe̔TזÉg߂hɂN鍂TCgJCǂł邪Cɑ΂Ă͍RC^[CL6e̍R̂̎gpɂ肩Ȃ̑Ή\ɂȂD܂Cpa͋}paɔׂƊ𗦂ႭCȂ炩̉PKvƍlĂDЂƂ̃Av[`́CLRe̔TזEÖ@CCu`jup悤ȕqWIÖ@C邢́CPD-1hRp悤ȃ`FbN|CgjQÖ@Ƒgݍ킹邱ƂłDɁCLRe̔TזEÖ@ɑ΂ϐ̋@炩ɂꂽDЂƂ́C^ꂽLRe̔TזȄłDLRe̔TזȆ̏́C̏ꍇCꂽ`qɑ΂hƉuɋNDЂƂ̏dvȑϐ̋@́CȒrCȂ킿CaזECD19̔ƂɂƉủłC10`20̋}på҂ɂĂ݂Dɋɒ[ȏꍇɂ́Cpa獜aւ̌n]ɂ肪̓邱ƂD
@ɑ傫ȉۑ́CBȂǂ̌Ō`ʓISɎÂ邽߂̃LRe̔TזEÖ@̊JłDŌ`ɂŏ̃LRe̔TזEÖ@́CC_oזECt҂ɂāCt_e1CD171WIƂLRe̔TזEɂ{sꂽCL͎Ȃ<a href="#R8"><sup>8)</sup></a>D]ڐ̐tזE̊҂ɑ΂J{jbNAqh[[IXWIƂLRe̔TזEÖ@̗ՏɂẮC̑ւ̏dĂȓŐɂ炸CqϓIȍR񉞓͂Ȃ<a href="#R9"><sup>9)</sup></a>D܂C2̌O[vɂCẽ`VLi[[ErbB-2WIƂLRe̔TזEÖ@̗Տ񍐂ĂDCD284-1BBȂ3̕⏕hêpʂ̃LRe̔TזEêpł́C҂̓TCgJCoǌQѐErbB-2𔭌鑟ɑ΂Őɂ莀S<a href="#R10"><sup>10)</sup></a>DC2̕⏕hêpʂeãLRe̔TזEṕCՏIɗLvȍRʂ̏؋ƂƂɈSɊ̂<a href="#R11"><sup>11)</sup></a>CCȂ锭W҂D

<h2>3DLSȃLRe̔TזEÖ@̊Jւނ</h2>
@LRe̔TזEÖ@ɂ͂܂܂ׂۑ肪CẺɂނi߂ĂDȉɁC_т̉ɂނʂɂĉi<a href="#F4">}4</a>j

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@LRe̔TזEÖ@ɂۑ肨т̉@</strong>
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2017/07/Hosen-6.e005-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2017/07/Hosen-6.e005-Fig.4.png&amp;caption=fig4-caption-text]

@1jTזËڍsF܂łȂCTזEÖ@̐̂߂ɂTזEזE̕ʂɌIɈڍs邱ƂdvłDTזËڍs͌t̎ÂɂĂ͂܂傫Ȗł͂ȂCŌ`̎ÂɂĂ͂߂ďdvłD̂gD͐ۑgDɂ܂TזEZɂƍlĂD܂CזETזE̐Z}̂ɖ𗧂PJCVOi`B}邱Ƃ񍐂ĂD`FbN|CgjQ܂Ȃǂ̖ƉuÖ@ɉȂ̊҂ɂāC΂΂gDւTזE̐Z̕ŝ邱Ƃ͖炩łDLRe̔TזEւ̃PJCê̓ɂ蓯̃PJCY邪gDւ̈ڍsPꂽƂ錤邪<a href="#R12"><sup>12)</sup></a>CTזËڍsP邽߂̂ʉꂽ@͂܂ɂȂCbƉuw̒m̏WςƂ̉p]܂D
@2jR̂ɑ΂ِFLRêJ邤łƂdvȃ|CǵCזEƐȍזEƂSɋʂłWIoƂłDCۂ̂ƂC܂łɎĂWIRׂ̂Ă͐ȍזEɂĂ݂̂̂΂łD̏ꍇCɂ菝QgD̂ɂP퐫̈ێɕK{ǂŕWIƂȂ肤邩ǂ܂DƂ΁CCD19WIƂLRe̔TזȄꍇCCD19𔭌鐳BזE̎ł炷Cꎩ̂͐т₩̂ł͂Ȃ̂ŋeDȂCĂ̂ȂgDƂ͂Ȃ̂ŁCꂪLRe̔TזE̕WIR̓ɂĂDɂٓIȍRƂẮCRĈψقɗRR_IɗL]łD̑\IȂ̂OIuXg[}ɂđ݂EGFRvIIIłCہCR̗Ö@уLRe̔TזEÖ@̊JiłDCEGFRvIII͓ȗłDߔN̂Qm͂̐iɂ薾炩ɂꂽ悤ɁCזÊψق͊҂ɂ傫قȂC܂CЂƂ̊҂̂̂Ȃɂ傫ȑl邽߁Ĉ񊳎҂ɓKp̉\ȂɓٓIȕψٍR̓͂߂Ăނ낤Dŋ߁CɓٓIɐ铜Cُ̈ɂ`RTn-Muc1WIƂ鎡Ö@񍐂ꂽ<a href="#R13"><sup>13)</sup></a>D̃Av[`Muc1𔭌鑽̂ɓKp\ŁC̓WJ҂Dɑ΂ِ߂ʂ̕@ƂāCLRe̔TזE邽߂2ȏ̍ȒgpZpD̂ЂƂ̐헪2̕ʁX̃LRê𔭌̂ŁC̎êCD3čC⏕hêłƂ̂ł<a href="#R14"><sup>14)</sup></a>D܂C̎êɑ΂R݂Ƃ̂TזE̊NƂ݂łDɁCV݂ƂāC1̎ê̊2̎ê̔UC2̎êRFƂ̂TזEƂ݂JĂ<a href="#R15"><sup>15,16)</sup></a>DɁCTזĚ@ƂāCȍזEɔRɑƂɊ𖳌ɂjQLRêJĂ<a href="#R17"><sup>17)</sup></a>DjQLRê̍זEhCTזEêɗRhCɑPD-1CTLA-4̂悤ȖƉu}̎ễVOi`BhCDLRêёjQLRê̗𔭌TזELRêɑ΂R݂̂𔭌鐳ȍזEɑTזE͊邪CLRêɑ΂RёjQLRêɑ΂R̗𔭌邪זEɑƁCjQLRễVOiLRễVOiTזE̊}D
@3jea̒ꂽLRéFɂĂȂR͂߂Ă܂łCȑgDɔׂgDɂĈُɍĂR͂Ȃ肠DƂ΁CHER2̑\IȂ̂łD̂悤ȍRɑ΂LRe̔TזEÖ@\ɂ̂CLRê̐ea̒łDقƂǂ̃LRếCRHER2R̂łgXd}uin[Zv`ĵ悤ȍea̎ÍR̂ɊÂč\zDĈ悤ȍeãLRếCȑgDɔHER2FčUĂ܂DŁCLRê̐ea𒲐邱ƂɂCזE͍U邪ȍזE͍UȂzIȃLRê̍쐻݂Ă<a href="#R18"><sup>18)</sup></a>D
@4jLRe̔TזE̐F܂ŁCقڂׂẴLRe̔TזEÖ@̗Տɂďdȕp݂ꂽDCŌ`ւ̉pɂނCɊ̍LRê̊JlCLQȕp̉\͍܂DāCTזE̊̋т̎𐧌䂷邱ƂdvDЂƂ̕@͎E`q̓łD<em>iCasp9</em>`qƂ΂鎩E`q̗ĹCזËڐAĂ銳҂̈ڐAБΏha̎ÂɂėՏIɗ؂Ă<a href="#R19"><sup>19)</sup></a>DiCasp9͒ᕪq̓^ɂʑ̉ĊJXp[[9ƂȂA|g[VXUD܂CdĂȕp̐Ƃɂ̒ᕪq𓊗^΃LRe̔TזE͔rDtɁCKvȂƂLRêIɂ@JĂDƂ΁CCD3čƕ⏕hêƂʌ̃|yv`hɂC炪ᕪq̓^ɂh`B悤ɂȂƂVXeł<a href="#R20"><sup>20)</sup></a>D邢́CɓٓIȍR̂זEɌĂāCFcẽhCFLRêɂ肻̂זEUƂA_v^[݌^̃LRê񍐂Ă<a href="#R21"><sup>21)</sup></a>DA_v^[Fcêɂ炸܂܂Ȃ̂gp\ł<a href="#R22"><sup>22,23)</sup></a>Dʂ݂̎ƂāCLRe̔TזEɃtB[hobN@\Ƃ̂DƂ΁CC^[CL6̓TCgJCoǌQ̎vȃ}[J[łCLRê߂𔽉fDŁCߏȃC^[CL6măLRê̊}VXe\z邱Ƃł΁CLRểߏȊɂ镛pӂƍlD
@5jLRe̔TזE̋FLRe̔TזE̗Lコ邽߂ɖȂЂƂ̐헪́CƉu͂炫₷Ȃ悤ȋ@\^pNLRe̔TזEꎩ̂ɔ邱ƂłDƂ΁CC^[CL12𔭌LRe̔TזE̗L񍐂Ă<a href="#R24"><sup>24)</sup></a>DC^[CL12͂Ƃ͂ȍRpTCgJĈЂƂłCRƉuזEъlƉuזEɑ΂ʓIȍpĂč\zD悤ȃACfBAƂāCC^[CL18HVEMiherpes virus entry mediatorj𕪔傷LRe̔TזE񍐂Ă<a href="#R25"><sup>25)</sup></a>Dŋ߂ł́CזEQ\ނCP邽߂̖܂́g^щhƂĂ̋@\dLRe̔TזE̕񍐂DƂ΁CLRê̎hɉăC^[CL12CǑĩTCgJCCR`FbN|CgŔCdِR̂ȂǂYCRƉunhtWFȂǂ̃^pNY肷悤ȃVXeł<a href="#R26"><sup>26)</sup></a>D̃VXep邱ƂɂC̋Ǐł̂݁ĈƉu𑣐i^pN𔭌邱Ƃł̂ŁCSgւ̉eŏɗ}邱Ƃ\łD
@6j܂܂ȕ⏕hê̗pF܂ŗՏpĂLRe̔TזEɂẮC⏕hêƂCD28邢4-1BBpCCD19WIƂLRe̔TזEÖ@ɂėǍDȐтcĂDCD28邢4-1BB̈ႢɂĂ͂܂܂ɌĂD̓̐vCD28̂ق悢Ǝv邪C4-1BB̂قԂɂ킽̓ɎcƍlDāCCD28LRê̗͊Û߁C邢́CڐA܂ł̂Ȃ̎Ö@ɗp̂悢ȂDC4-1BBLRê͍ŏIIȎÖ@ɗpĒԂ̖ƉůĎ҂ł邩ȂDCD284-1BBɂ킦CCD27COX40CGITRCICOS܂ށCق̑̕⏕hê݂ĂD
@7jTזE̔敾̉є敾̉񕜁FIȍR̔IщǂɂāCTזE͋@\IɃGtFN^[𔭌łȂȂCTזE̔敾Ƃ΂ԂɂȂ<a href="#R27"><sup>27)</sup></a>D̂񊳎҂ɂāCƂɂ̋ǏɂẮCɓٓITזE敾̏Ԃɂ<a href="#R28"><sup>28)</sup></a>D敾̏Ԃ̌ȓ́CTזEŏIIɑB\Ƃł<a href="#R29"><sup>29)</sup></a>D̖ɑΏ邽߂ɖȕ@́CRPD-1jQ܁CRPD-L1jQ܁CRCTLA-4jQ܂̂悤ȍR`FbN|CgR̂𕹗p邱ƂłDʂ̐헪ƂẮCLRe̔TזEɑ킦敾ɂTזE邱ƂlĂDƂړIȕ@Ƃčl̂́CQmҏWɂTזEPD-1êPD-L1ɔ}}ɉȂ悤ɂ邱ƂłCłɂ̕񍐂<a href="#R30"><sup>30)</sup></a>D̂悤ɁCQmҏWpTזẺς͋Zp̂߂܂WɂƂȂǂǂeՂɂȂ<a href="#R31"><sup>31)</sup></a>D
@8jTזȆӁFߔNCTזE̕@\̔ɂāC̑ӂdvł邱Ƃ炩ɂĂD͉h{̌͊ɂTזȆӂɉeƉujQ<a href="#R32"><sup>32)</sup></a>DɂẮCזETזEƂ̂ŃOR[XɗpɂNTזE̋@\}<a href="#R33"><sup>33)</sup></a>D܂C񂾂זEoꂽK<sup>+</sup>ɂ肪ɂK<sup>+</sup>̃x͌5`10{ȂCTזE̊͂ɑjQ<a href="#R34"><sup>34)</sup></a>D̂悤ɁC̉h{f̗p\̒ቺӔp̒~ςƂĂωTזE̋@\ɈeڂD܂CLRê̂⏕hê̈ႢɂTזȆӂւ̉eɂĂ񍐂CCD28LRe̔TזE͍DC̉𓜂𑝋C4-1BBLRe̔TזE̓~gRhA̐𑝋b_̎_𑝉<a href="#R35"><sup>35)</sup></a>D̒mƂɁCזEӂ̐TזE̋@\𐧌䂷邱ƂɂCLȃLRe̔TזEÖ@\ɂȂƍlD

<h2></h2>
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<h2> </h2>
<ol>
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<li id="R12"><span class='au'>Di Stasi, A., De Angelis, B., Rooney, C. M. et al.</span>: <span class="ti">T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.</span> <span class='so'>Blood, 113, 6392-6402 (2009)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/19377047" target="_blank">PubMed</a>]</span></li>
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<li id="R14"><span class='au'>Kloss, C. C., Condomines, M., Cartellieri, M. et al.</span>: <span class="ti">Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells.</span> <span class='so'>Nat. Biotechnol., 31, 71-75 (2013)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/23242161" target="_blank">PubMed</a>]</span></li>
<li id="R15"><span class='au'>Roybal, K. T., Rupp, L. J., Morsut, L. et al.</span>: <span class="ti">Precision tumor recognition by T cells with combinatorial antigen-sensing circuits.</span> <span class='so'>Cell, 164, 770-779 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26830879" target="_blank">PubMed</a>]</span></li>
<li id="R16"><span class='au'>Morsut, L., Roybal, K. T., Xiong, X. et al.</span>: <span class="ti">Engineering customized cell sensing and response behaviors using synthetic Notch receptors.</span> <span class='so'>Cell, 164, 780-791 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26830878" target="_blank">PubMed</a>]</span></li>
<li id="R17"><span class='au'>Fedorov, V. D., Themeli, M. & Sadelain, M.</span>: <span class="ti">PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses.</span> <span class='so'>Sci. Transl. Med., 5, 215ra172 (2013)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/24337479" target="_blank">PubMed</a>]</span></li>
<li id="R18"><span class='au'>Liu, X., Jiang, S., Fang, C. et al.</span>: <span class="ti">Affinity-tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index against tumors in mice.</span> <span class='so'>Cancer Res., 75, 3596-3607 (2015)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26330166" target="_blank">PubMed</a>]</span></li>
<li id="R19"><span class='au'>Di Stasi, A., Tey, S. K., Dotti, G. et al.</span>: <span class="ti">Inducible apoptosis as a safety switch for adoptive cell therapy.</span> <span class='so'>N. Engl. J. Med., 365, 1673-1683 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/22047558" target="_blank">PubMed</a>]</span></li>
<li id="R20"><span class='au'>Wu, C. Y., Roybal, K. T., Puchner, E. M. et al.</span>: <span class="ti">Remote control of therapeutic T cells through a small molecule-gated chimeric receptor.</span> <span class='so'>Science, 350, aab4077 (2015)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26405231" target="_blank">PubMed</a>]</span></li>
<li id="R21"><span class='au'>Kudo, K., Imai, C., Lorenzini, P. et al.</span>: <span class="ti">T lymphocytes expressing a CD16 signaling receptor exert antibody-dependent cancer cell killing.</span> <span class='so'>Cancer Res., 74, 93-103 (2014)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/24197131" target="_blank">PubMed</a>]</span></li>
<li id="R22"><span class='au'>Ma, J. S., Kim, J. Y., Kazane, S. A. et al.</span>: <span class="ti">Versatile strategy for controlling the specificity and activity of engineered T cells.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 113, E450-E458 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26759368" target="_blank">PubMed</a>]</span></li>
<li id="R23"><span class='au'>Rodgers, D. T., Mazagova, M., Hampton, E. N. et al.</span>: <span class="ti">Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies.</span> <span class='so'>Proc. Natl. Acad. Sci. USA, 113, E459-E468 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26759369" target="_blank">PubMed</a>]</span></li>
<li id="R24"><span class='au'>Kerkar, S. P., Muranski, P., Kaiser, A. et al.</span>: <span class="ti">Tumor-specific CD8<sup>+</sup> T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts.</span> <span class='so'>Cancer Res., 70, 6725-6734 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20647327" target="_blank">PubMed</a>]</span></li>
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<li id="R34"><span class='au'>Eil, R., Vodnala, S. K., Clever, D. et al.</span>: <span class="ti">Ionic immune suppression within the tumour microenvironment limits T cell effector function.</span> <span class='so'>Nature, 537, 539-543 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/27626381" target="_blank">PubMed</a>]</span></li>
<li id="R35"><span class='au'>Kawalekar, O. U., O'Connor, R. S., Fraietta, J. A. et al.</span>: <span class="ti">Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells.</span> <span class='so'>Immunity, 44, 380-390 (2016)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/26885860" target="_blank">PubMed</a>]</span></li>
</ol>
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