ugtBbNɂ镁ՓIȐqRab^pN

<strong>ѓTFEc</strong>
ikww@Ȋw A@\͕j
emailF<a href="mailto:n.ohbayashi@m.tohoku.ac.jp">ѓTF</a>C<a href="mailto:nori@m.tohoku.ac.jp">c</a>
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̈Zr[, <strong>2</strong>, e006 (2013)@<a href="http://dx.doi.org/10.7875/leading.author.2.e006">DOI: 10.7875/leading.author.2.e006</a>
Norihiko Ohbayashi & Mitsunori Fukuda: <strong>Rab GTPases and their roles in membrane traffic.</strong>

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<h2>v </h2>
@^j̍זEɑ݂Gh\[⃊\\[Ȃǂ̃IKlזÉCꂼꂪƗĂ킯ł͂ȂCugtBbNɂ薧ڂɂ肠ĂDRasX[p[t@~[ɑRab^pŃC̃ugtBbNɂĂ߂ďdvȐqłDRab^pN̋@\ُ̈͐_oƉu͂߁Cɑɂ킽aԂɂĂ邱ƂCRab^pN͌X̍זE̐łȂC܂܂ȍ@\ɂsłƍlĂDł́CRab^pNɂ鐧@\₻̐@\CāCRab^pN̋@\ُƂɂƂȂaԂɊւŋ߂̒mTD

<h2>͂߂</h2>
@ÊɂčꐳtH[fBOꂽ^pN╪^pŃCSŴуgXSWlbg[NւĂ܂܂ȖړInւƉ^΂DƂ΁CoHɂזE̊OזEւƗA^pNCGh\[Ȃǂ̃IKlɗA^pND҂̗ÁCזEGhTCg[VXɂIKlɓB̂Ƃ܂ĕGȃlbg[N\zĂCꂼ̃IKl₻̓eĂD̃lbg[N͊{IɎdɕ܂ꂽE̍sɂ萧䂳ĂC^̃IKlɂς݉׃^pN̑IʂƏȄoC[^[^pNɂACWIƂȂ閌ւ̌qїZƂ_Ci~bNȖԂƂȂD̖Ԃ𑍏̂ăugtBbNiA邢͏EAjƂłi<a href="#F1">}1</a>jD܂ŋ߂ł́CoϗpؗpčזEWXeBNXƂ΂D

<a name="F1"></a><div id="fig1-caption-text" style="display: none;"><strong>}1@ugtBbN̊T</strong>
ugtBbŃC܂C^̃IKl̈ꕔgohCNXȂǂɂR[gƂƂɁC̍тƂ邱ƂɂAE`D̍ہCEɈڍs閌̐o̐́gIʁhsDɁCR[g^pN͗AE𗣂igER[ghjCזEiɂāgAhCWIƂȂIKlɓBD̂̂CWIƂȂ閌ւƁgqhgZh邱ƂɂCAE̐ςׂ͕݉WĨIKlւƎ󂯓nDIʂяoCER[gCACqCZ̊eXebvɂRab^pNт̃GtFN^[^pNi[^[^pNCq^pNȂǁj̋@\D܂CZ̉ߒɂẮCAEɊ܂܂v-SNAREivesicle-SNAREjƕWIƂȂ閌ɑ݂t-SNAREitarget-SNAREjƂSNARÊ`CZ𑣐iD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/05/Fukuda-2.e006-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2013/05/Fukuda-2.e006-Fig.1.png&amp;caption=fig1-caption-text]

@ߔNC̃ugtBbNɂ镁ՓIȐqƂĒڂ߂Ă̂Rab^pNłDRabt@~[RasX[p[t@~[ɑᕪqG^pN̂Ȃōő̃t@~[`Dqgł66ނRab^pNiGTPasehCȊÕhCCقƂ͂قȂRab44Rab45܂ށj񍐂Ă<a href="#R1"><sup>1)</sup></a>CꂼꂪٓIȃugtBbN𐧌䂷̂ƍlĂDRab^pŃCق̒ᕪqG^pNƓC2̃kNI`hԂTCN镪qXCb`Ƃċ@\DȂ킿CGTP^̊ԂGDP^̕sԂƂ̂ł̃RtH[VϊDRab^pN͖ɉtIɌ邪CRab^pN̊̏ԂɈˑĂCʓIɁCGTP^ł銈^Rab^pŃCC[ɑ݂1܂2̃VXeCcăQjQjiavjj邱Ƃɂ薌ɌĂDɌ^Rab^pŃĈ̂Rab^pNɓٓIȃGtFN^[^pNƌCIKlɂ鏬ȄoCE̍זEiɂAC邢́CٓIȃIKlւ̌qZ𐧌䂵Ă<a href="#R2"><sup>2)</sup></a>D
@ł́C瑽ʂȖSRab^pN̐@\␶@\CāCRab^pN̋@\j]ɂaԂ̔ǋ@\ɂĊTD

<h2>1DqXCb`ƂĂRab^pNɂIIt̐</h2>
@זEɂčꂽRab^pŃĈ܂܂ł͖Ɍ邱Ƃ͂łȂDVKɍꂽRab^pŃC܂CRabGXR[g^pNiREPFRab escort proteinj̍pɂCRabQjQj]ڍyfiRab-GGTFRab geranylgeranyl transferasejɎ󂯓n<a href="#R3"><sup>3)</sup></a>DɁCRab-GGTRab^pNC[ɑ݂VXeCcQjQj<a href="#R4"><sup>4)</sup></a>D̎CɂCRab^pN͍זEIKlƑݍp邱Ƃ\ɂȂDÂāCRab^pNɓٓIȃOAjkNI`hqiGEFFguanine-nucleotide exchange factorj̍pɂGDPGTPւ̌ijs<a href="#R5"><sup>5)</sup></a>DRab^pNGTPRab^pÑXCb`IуXCb`IIƂ΂̈ɂč\ωNCXCb`̈XCb`ԗ̈ɃGtFN^[^pN邱Ƃ̂ł銈ԂɂȂ<a href="#R6"><sup>6)</sup></a>D^Rab^pNƌGtFN^[^pŃC̋@\ɉăugtBbNɂ邳܂܂ȃXebv𐧌䂷D܂łɕ񍐂ꂽGtFN^[^pN͑푽lłĈɁC̗qׂD
@āCɌ^Rab^pŃCugtBbNɂƕsKvDRab^pNꎩ̂ɂGTPGDPɉGTPaseĂ邪C̍pł͕s\ŁCRab^pNɓٓIGTPase^pNiGAPFGTPase-activating proteinj̏𓾂邱ƂRab^pN͕s<a href="#R7"><sup>7)</sup></a>DsꂽGDP^Rab^pŃCTCg]ɑ݂GDP𗣗}qiGDIFGDP dissociation inhibitorj̍pɂCC[̃QjQjێ܂ܖDQjQj͐ełTCg]ł͕sł邪CGDIQjQjɑ΂VyƂċ@\邱Ƃɂs^Rab^pNTCg]ɂĈɕێCĊ܂őҋ@邱Ƃł<a href="#R8"><sup>8)</sup></a>D[ƂɁCREPGDI͂ǂs^Rab^pÑVyƂĂ̋@\CCꂽRab^pNɑ΂eaƂ_ɂė҂͑傫قȂDREP̓QjQjRab^pNƖCRab^pNƂɑ΂eaɂđ傫ȍ͂ȂCGDI̓QjQjRab^pNɑ΂Ĉ|IɍeaCRab^pN̍ėpɂGDȈdv̍ƂȂĂ<a href="#R9"><sup>9)</sup></a>Ds^Rab^pN͍ŏIIGDI𗣂邱ƂɂӂіƑݍp邱Ƃ\ɂȂCGEF̍pɂGTP^̊ԂւƕϊDȂCGDỈ𗣂ɂẮCGDIuqiGDFFGDI displacement factorjɂsƂ̕񍐂邪<a href="#R10"><sup>10)</sup></a>C̋@\͈ꕔRab^pNɑ΂Ă݂̂łRZTX͓ĂȂD
@̂悤ɁCRab^pN̊̃XCb`CсCɂƂȂIKlւ̋Ǎ݂̃IIt̃TCŃCGEFCGAPCGGTCREPCGDIƂ^pN̋pɂ鐧Ăi<a href="#F2">}2</a>jD

<a name="F2"></a><div id="fig2-caption-text" style="display: none;"><strong>}2@XCb`^pNRabɂ鏬EA̐@\</strong>
Rab^pŃCGTPƌ^ƁCGDPƌs^Ƃ̂TCN镪qXCb`Ƃċ@\DRab^pN̊ƕśCꂼCGEFGAPɂ萧䂳D1jVKɍꂽRab^pN͂܂REPƌC2jRab-GGTƑݍp邱Ƃɂ莉CiQjQjjC3jGEF̍pɂ芈IKlɌD4j^Rab^pN̓GtFN^[^pNIKlɃN[g邱Ƃɂ胁ugtBbN𑣐iDɁC5j^Rab^pNGAPɂsD6js^Rab^pNGDI̋@\ɂIKl邪C7jGDFGEF̍pɂ芈CӂуIKlւƂǂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/05/Fukuda-2.e006-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2013/05/Fukuda-2.e006-Fig.2.png&amp;caption=fig2-caption-text]


<h2>2DRab^pN̍זEǍ݂ƃugtBbN</h2>
@ÊɂĐVKɍꂽ^pŃCSŴoRăgXSWlbg[NɓBƂőIʂC܂܂ȗẢߒւ邱ƂɂȂDƂ΁Cz̎YOR[XÂ̗AȂǂɂ͍זEւ̕oHpĂC̗AoHłRab3CRab27CRab10Ȃǂ􂷂<a href="#R11"><sup>11,12)</sup></a>DזE⏉Gh\[ɂRab5݂CGhTCg[VXɂזEɎ荞܂ꂽEƏGh\[Ƃ̗Z𑣂<a href="#R13"><sup>13)</sup></a>D܂CGh\[̓\[eBOGh\[Ƃ΂CזEזE̊O荞܂ꂽ܂܂ȃIKlւƐU蕪@\CRab5łȂCRab4Rab21͂<a href="#R14"><sup>14,15)</sup></a>CRab^pN݂DזEɎ荞܂ꂽ̂svȂ̂́CGh\[番Gh\[ւă\\[ƗZ邱Ƃɂ蕪DGh\[烊\\[ɂĂRab7dvȋ@\S<a href="#R16"><sup>16)</sup></a>DCėṕׂCGh\[瑦ɍזEւƂǂߒirapid recyclingjƁCǒŜ̋ߖTɑ݂GhTCg[VXTCNRp[ggiERCFendocytic recycling compartmentjւƉ^΂ꂻo肵TCNOGh\[ɂזEւƂǂߒislow recyclingj́CꂩoRDO҂̉ߒɂRab4<a href="#R14"><sup>14)</sup></a>C҂̉ߒɂRab11vȂ͂炫ĂCזEڒqłCeOJhw̃TCNOɂRab11ϋɓIɂĂ<a href="#R17"><sup>17,18)</sup></a>D܂CgXtFêꕔ̃A~m_ÂȂǃTCNOGh\[Ɉڍŝ͕ȂƍlĂCŋ߁CRab12ɈˑIɃ\\[ɃN[gƂVK̗AߒoĂ<a href="#R19"><sup>19,20)</sup></a>DɁCGh\[CGh\[CTCNOGh\[́CgXSWlbg[NɂEtsAĂC̏ڍׂ͂̂ɏqׂD

<h2>3DRab^pÑIKlւ̋Ǎِ݂̓</h2>
@Rabt@~[\邻ꂼ̃o[͓ٓIȖւ̋Ǎ݂CŗL̃ugtBbN𐧌䂵ĂƍlĂi<a href="#F3">}3</a>jDƂ΁CRab1Rab2͏ÊуSŴɋǍ݂ďÊƃSŴƂ̂̃ugtBbN𐧌䂵<a href="#R21"><sup>21)</sup></a>CRab3͕召EɓٓIɋǍ݂ăVivXEȂǂ̃GL\TCg[VX𐧌䂵Ă<a href="#R11"><sup>11)</sup></a>Dł́CRab^pN̖ւ̋Ǎ݂͂ǂ̂悤ɐ䂳Ă̂낤D܂ŁCȉɏqׂ悤ȕ̃f񎦂ĂC炭Cꂼ̃f𕡍Iɗp邱ƂɂRab^pN̋Ǎ݂͋K肳Ă̂ƎvDRab^pN1\ׂĂ݂ƁCRabt@~[̂ł͕ۑĂ邪CRasRhoȂǂق̒ᕪqG^pNɂ݂͑ȂٓIȖ5A~m_cȂz5ɑ݂F1`F5Ƃ΂ĂDɁCSF1`SF4Ƃ΂RabTut@~[̂ł悭ۑꂽrIA~m_z4ɑ݂ĂDF1`F5SF1`SF4̃A~m_zRab^pN̋ǍݐK肷Ƃ̃f񎦂Ă<a href="#R22"><sup>22)</sup></a>D

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@זEɂRab^pN̋Ǎ݂Ƌ@\</strong>
זEɂ镡GȃIKllbg[N̂قƂǂׂĂ̋ǖʂɂāCRab^pN͏dvȖSĂD̂C\IȉߒɂĂ͂ӂꂽĈق̂̂ɂĂ͕Qlɂꂽ<a href="#R2"><sup>2)</sup></a>D
F̐́CRab^pÑAC\tH[̔ԍ\킷DERCFendocytic recycling compartmentCGhTCg[VXTCNRp[ggDERGICFER-Golgi intermediate compartmentCE-SW̒ԋD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/05/Fukuda-2.e006-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2013/05/Fukuda-2.e006-Fig.3.png&amp;caption=fig3-caption-text]

@̂قɂCGEFǏIRab^pNGTP^ɕϊĊCGDIƂ̐eaቺ邱Ƃɂ肻̉𗣂𑣂āCRab^pNٓIȖƌƂ̃f񏥂ĂDƂ΁CRab27AGEFƂĒmDENN/MADDRab27Ãm\[ւ̋Ǎ݂𐧌䂵ĂƂ̕񍐂<a href="#R23"><sup>23)</sup></a>CRab5GEFłRabex-5~gRhAɈُIɔƖ{͏Gh\[ɋǍׂ݂Rab5~gRhAɋǍ݂悤ɂȂƂ̕񍐂<a href="#R24"><sup>24)</sup></a>C̃f̗ÂɂȂĂD̂悤ɁCGEFRab^pN̋Ǎݐɂvȃ^pN̂ЂƂƍl邪Ĉ߂ɂ́CRab^pNΉGEFɓٓIȖɋǍ݂KvCɂ́CIKlɑ݂CmVg[ɑ΂GEF̐eaĈɏqׂRabJXP[ĥ悤ȕq@\KvɂȂD
@ɁC^Rab^pNٓIȃIKlɋǍ݂ƁCЂẪGtFN^[^pN邱ƂɂCRab^pN𖌂ɂĈ艻ĂƂ̕񍐂DƂ΁CGh\[ɋǍ݂Rab9̓GtFN^[^pNłTIP47Ƃ̌̋Ǎ݂ɏdvł<a href="#R25"><sup>25)</sup></a>D܂CGh\[ɋǍ݂Rab5͂̃GtFN^[^pNRabaptin-5Ƃ̌ԐړIRabex-5Rab5̂ɃN[gDRabex-5Rab5GEFƂċ@\邽߂Rab5邱ƂɂȂCRab5̋Ǎ݂艻<a href="#R26"><sup>26)</sup></a>DȂ킿CGtFN^[^pNƂ̌Rab^pN̋Ǎ݂ɂƂ萳̃tB[hobNIȗvf܂ނƍl邱ƂłD

<h2>4DRab^pNɂAς݉׃^pN̑IʂƏȄo</h2>
@IKl̂s鏬ÉC̕\ʂCOPICOPIIC邢́CNXȂǂ̃R[g^pNɂ肨ĂD̃R[g^pN͂Arf/Sart@~[ɑᕪqG^pNɂ萧䂳Ȃ狟^̃IKlɏWς邪CAׂς݉׃^pN̑Iʂ̉ߒɂRab^pNdvȖ͂ĂD\\[Ɋ܂܂_yf͖^pNł}m[X6-_êɌăgXSWlbg[NGh\[ւƗA邪CGh\[ɓB_yf̓}m[X6-_ê𗣂Cڂ͂}m[X6-_ê͂ӂуgXSWlbg[NւƂǂėpDRab9̃GtFN^[^pNłTIP47̓}m[X6-_ê̍זËƂ̌\CGh\[ɑ݂Rab9TIP47TIP47ƃ}m[X6-_êƂ̌܂CGh\[ɂ}m[X6-_ê̗AEւ̑IʂƏo肪i<a href="#R27"><sup>27)</sup></a>D܂Cʂ̗ƂāCg}[Ƃ΂^pN̂Dg}[̓Gh\[ɂăR[g^pNƂċ@\邪CRab7̃GtFN^[^pNƂĂ@\ĂCRab7̓g}[Ƃ̑ݍpăgXSWlbg[NɗAς݉׃^pN̑IʂƏȄoɂĂ<a href="#R28"><sup>28)</sup></a>D

<h2>5DRab^pNɂ핢E̒ER[g</h2>
@قƂǂ̗AE̓R[g^pNɂ肨Ă邽߁CWIƂȂ閌ɗZ܂ɃR[g^pNEEiER[gjKvDł́CNXˑGhTCg[VX̂̂̒ER[gɁC̕q@\DזEɑ݂郊łzXt@`WCmVg[4,5-rX_FăNXA_v^[̂łAP-2キƁC̃Li[[AAKAP-2̃ʃTujbg_邱ƂɂAP-2̍זEւ͈̌艻DɁCAP-2gXtFêȂǂ̐ς݉׃^pNFăNXW邱ƂɂC핢E`<a href="#R29"><sup>29)</sup></a>D̃NX핢EɂRab5݂ĂCRab5ƂGEFłGAPVD1ihRME-6jăNX핢EER[g<a href="#R30"><sup>30)</sup></a>DȂ킿CGAPVD1͔핢EAAK𗣂C邢́CRab5̃GtFN^[^pNłzXt@`WCmVg[3-Li[[zXt@`WCmVg[zXt@^[[N[g邱ƂōזE܂ꂽzXt@`WCmVg[4,5-rX_̃xቺ肷邱ƂɂCNX핢E̒ER[gЂN̂ƍlĂD

<h2>6DRab^pNɂAËړ</h2>
@^̃IKlo肵AE͔ǂAN`tBgƂזEiɂĉ^΂ړIñIKlɓBDǂ͊j̋ߖTɑ݂ǌ`SזE̕ӉɂނĉтĂCӉɂނsAɂ̓LlV[^[^pNC΂̕ɂނtsAɂ̓_Cj[^[^pN@\D̃[^[^pNƗAEƂȂ郊J[ƂāCRab^pN͏dvȖSĂ<a href="#R31"><sup>31,32)</sup></a>DƂ΁CGh\[ɑ݂Rab14FăLlV-3ڂɌ邱ƂɂCFGFễSŴGh\[ւ̏sA䂳Ă<a href="#R33"><sup>33)</sup></a>D܂CSŴɑ݂Rab6̃GtFN^[^pNƂRabkinesin-6񍐂Ă邪C̓LlV-6̃TujbgƂĒmCזEɏdvȖ͂Ă<a href="#R34"><sup>34)</sup></a>Dȏ́CRab^pNƃLlV[^[^pNƂ̒ړIȑݍpɂ̂CEɂRab^pNGtFN^[^pNLlV[^[^pNƊԐړIɑݍpP[X񍐂ĂDƂ΁CRab3DENN/MADDăLlV[^[^pNɑݍpCRab3zEj[̎ɂďsɗA<a href="#R35"><sup>35)</sup></a>D܂CÊSŴɑ݂Rab1A̓mTCgiFfזEjɂ郁m\[ɂ݂̏sA𐧌䂵Ă邪CɂCRab1AƃLlV[^[^pNƂȂGtFN^[^pN݂̑z肳Ă<a href="#R36"><sup>36)</sup></a>D
@ǂtsɗA_Cj[^[^pNRab^pNƂ̊֌WɂĂ̕񍐂DƂ΁CGh\[ɋǍ݂Rab7̓GtFN^[^pNłRILPă_Cjƃ_CiN`Ȃ镡̂ƑݍpCGh\[̋tsA𐧌䂵Ă<a href="#R16"><sup>16)</sup></a>D܂Cm\[ɋǍ݂Rab36́CRab36̃GtFN^[^pNłRILPă_Cjƃ_CiN`Ȃ镡̂ƑݍpCm\[̋tsA𐧌䂵Ă<a href="#R37"><sup>37)</sup></a>D
@AE͔ǂ𒷋ɂ킽_Ci~bNɓ̂ɑ΂CAN`tBgł̓~IV[^[^pN̂͂炫ɂZ̋ǏIȓĈ̂CזEւƗADRab^pNƃ~IV[^[^pNƂ̊֘Ał悭Ă̂ƂāCRab27A̗Ⴊi<a href="#F4">}4a</a>jDm\[ɋǍ݂Rab27A̓GtFN^[^pNłSlac2-aimelanophilinƂ΂jă~IVVaƑݍp邱ƂɂCm\[̔ǂAN`tBgւ̎󂯓nCāCAN`tBgɂǏIȓ𐧌䂵Ă<a href="#R38"><sup>38)</sup></a>DɁCRab27ASlac2-aƂ͈قȂGtFN^[^pNłSlp2-aɌ̑ςăm\[זEɌq<a href="#R38"><sup>38)</sup></a>Dق̗ƂẮCVivX㕔ɂ_o`BễGhTCg[VXƃTCNOɂ锭@\ɑ΂Rab11ƃ~IVVb̊֗^DiLTPFlong-term potentiationj̉ߒɂāCAMPA^O^~_ê܂Rab11zERab11̃GtFN^[^pNłFIP2ă~IVVbƑݍp邱ƂɂCVivX㖌ɗA<a href="#R39"><sup>39)</sup></a>D̂悤ɁCE邢̓IKlɂRab^pNƃ[^[^pNƂȂ͖ɂƂ܂Ȃ<a href="#R31"><sup>31)</sup></a>CIKlɓٓIȏEAɂِ̂ƍlD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@m\[̗ARab27A</strong>
iajǂAN`tBgɎ󂯓n郁m\[ɂRab27A݂C̃GtFN^[^pNłSlac2-a[^[^pNł~IVVam\[ɃN[gD̂̂CRab27A͂ЂƂ̃GtFN^[^pNłSlp2-aɌ̑ς邱ƂɂCm\[͍זEɌqD
ibjRab27ACSlac2-aC~IVVâꂩЂƂł@\NƁC̎Oҕ̂ɂ萧䂳郁m\[̃AN`AɈُCm\[͔ǂtsA邱Ƃɂj̎ӂɋÏWD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/05/Fukuda-2.e006-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2013/05/Fukuda-2.e006-Fig.4.png&amp;caption=fig4-caption-text]


<h2>7DRab^pNɂqіZ</h2>
@ʓIɁCAE͍ŏɌq^pNɂ鑊ݍpiq邢̓hbLOƂ΂jĖړInƂȂIKlƌD̂̂CSNAREisoluble NSF attachment protein receptorj^pN̍pɂAEƕWIƂȂ閌Ƃ̗ZND̉ߒɂĂRab^pN͌q^pNSNARE^pNƑݍpCqZ̃Xebvɐ[֗^ĂDq^pŃCЂƂ̔rI傫ȃ^pNɂ̂ƁC̃Tujbg\^pN̂ɂ̂́C傫2̃O[vɕ邱ƂłDЂƂ̃^pNɂ̂ƂẮCRChRC^pNip115CGM130CGCC185Ȃǂ̃SŴɋǍ݂SWt@~[^pNCEEA1ȂǂRab5GtFN^[^pNjVivg^O~l^pNȂǂ̕񍐂D܂C^pN̂ɂ̂ƂẮCHOPS/Vps-ĆCExocyst́CCOǴCGARP/VFT́CTRAPP̂Ȃǂ̕񍐂<a href="#R40"><sup>40)</sup></a>D
@Ê⏬E-SW̒ԋiERGICFER-Golgi intermediate compartmentjVXSWɗACOPIIEɂRab1݂ĂCЂƂ̐ƂāCȉ̃f񏥂ĂDRab1q^pNłp115COPIIEɃN[gCVXSWɂRab1̃GtFN^[^pNłGM130ҋ@ĂDāCGM130p115Ƃ̂`q^pNƂċ@\邱ƂɂCVXSW֏Eq<a href="#R41"><sup>41)</sup></a>DɁCGM130Syntaxin-5ȂǂSNARE^pNƑݍp邱ƂɂCẼVXSWւ̗Zi<a href="#R42"><sup>42)</sup></a>D
@Vivg^O~l^pN͂N[ɑ݂SHDhCRab27ƓٓIɌC召E̍זEւ̌qɂDזEPC12זEɂẮCziLcƂ΂jRab27AǍ݂CGtFN^[^pNłrabphilinƂ̌čזEɑ݂SNAP25ƌ邱ƂɂCzזEɌq<a href="#R43"><sup>43)</sup></a>D
@Gh\[ɑ݂Rab5́C̏펞^̕ψّ̂𔭌ƋȃGh\[UȂǁCGh\[̗Zɐ[ĂDRab5EEA1Rabenosyn-5ƂGtFN^[^pNRab5zGh\[ɃN[gCN[gꂽEEA1͂̃RChRChCēʑ̉邱ƂɂRab5zGh\[ǂq<a href="#R44"><sup>44)</sup></a>D܂CEEA1Syntaxin-6Ȃǂ̃Gh\[SNARE^pNƂCRab5zGh\[̗Z𑣐i<a href="#R44"><sup>44)</sup></a>DɁCRab5̃GtFN^[^pNɂ̓zXt@`WCmVg[3-Li[[zXt@`WCmVg[4-zXt@^[[邢̓zXt@`WCmVg[5-zXt@^[[ȂǂCRab5zGh\[ɃzXt@`WCmVg[3-_ZkD̂߁CzXt@`WCmVg[3-_ٓIɔFFYVEhCEEA1Rabenosyn-5́CRab5zGh\[ɂɕێ₷ȂDāCĚqZɂ͒ᕪqG^pNłȂCzXt@`WCmVg[̋@\dvƍl<a href="#R45"><sup>45)</sup></a>D
@זEׂ͂Ăψł͂ȂCȖhC\ƂɂזE@\̈ێɏdvȖ͂ĂD̍זE̓ٓIȃhCւ̕AɐAƂԁDƂ΁C̍זEɂ1@сiKIȔzuƂǂȂ鎲ɂCזËꕔOɓ˂o\jƂȓˋN\Dɂ̓hvV\}gX^`êȂǂG^pNêLxɊ܂܂ĂCזEO̊m邽߂̃ZT[\ƂĒڂĂD1@тɋɐA郊TCNOGh\[ɂRab11݂CGtFN^[^pNłRabin8EɃN[gDRabin8Rab8GEF߁CRab8̏EɃN[gDɁCRab8Sec15Ƃ̌N_ƂďEExocyst̂N[gזEɌq<a href="#R46"><sup>46)</sup></a>i<a href="#F5">}5a</a>jDȂCExocyst̂8̃TujbgȂ鋐ȃ^pN̂łCgXSWlbg[N⃊TCNOGh\[̗AEזE֌qSĂ<a href="#R47"><sup>47)</sup></a>D܂CɐA͏זE̒[-ɐ̌`ɂdvȖ͂ĂCRab8AmbNAEg}EXł͒[̍זEւ̋ɐÄُɂ鏬Oшޏk̏Ǐ<a href="#R48"><sup>48)</sup></a>D

<a name="F5"></a><div id="fig5-caption-text" style="display: none;"><strong>}5@RabJXP[h</strong>
iaj@тɗAAEExocyst̂ɂqۂɂ́CRab11Rab8ւ̕ϊiRab11Rabin8Rab8Exocyst́jND
ibjGh\[Gh\[ɕۂɂ́CRab5Rab7ւ̕ϊiRab5HOPŚRab7Rab5-GAPjND
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2013/05/Fukuda-2.e006-Fig.5.jpg" target="_blank">[Download]</a></div>[hs_figure id=5&amp;image=/wordpress/wp-content/uploads/2013/05/Fukuda-2.e006-Fig.5.png&amp;caption=fig5-caption-text]


<h2>8DRabJXP[h</h2>
@ЂƂ̃IKlniKωƁCɂƂȂRab^pN̕ϊDƂ΁CGh\[̐n̉ߒ݂Ă݂ƁCGh\[ɋǍ݂Rab5͌Gh\[ɂ݂͑CRab7݂ĂD̉ߒł́C܂CRab5HOPŜGh\[ɃN[gDHOPŜRab7GEFƂċ@\Vps39TujbgƂĂƂCɁCGh\[Rab7N[g<a href="#R49"><sup>49)</sup></a>i<a href="#F5">}5b</a>jDČGh\[łRab5GAP@\邱ƂɂRab5菜Ƃ񍐂̂<a href="#R50"><sup>50)</sup></a>CҒœɂĂRab5GAP̊֗^͖炩ł͂ȂD̂悤ɁCRab^pN̕ϊRab̃GtFN^[^pNCсCGEF邢GAPɂAIŒâƂꂽ͂炫ɂs邽߁CgRabJXP[hhƂ΂ĂDRabJXP[h̓ugtBbN̂܂܂ȋǖʂɂĔF߂Dɏqׂ1@т̌`̉ߒɂRab11Rab8̃JXP[hi<a href="#F5">}5a</a>j̈ł<a href="#R46"><sup>46)</sup></a>CRabin8̂悤ɁC1qɏ㗬ƂȂRab^pNił́CRab11j̊^Ƃ̌hCiRabhCjƁCƂȂRab^pNił́CRab8j̊hCiGEFhCjƂ킹^pN@\ǖʂł́CRabJXP[h@\ĂꍇDC1qɑ݂RabhCGEFhCƂʁX̐@\SĂꍇ̂ŒӂKvł<a href="#R51"><sup>51)</sup></a>D

<h2>9DRab^pN̋@\sSƎ</h2>
@܂ŏqׂĂ悤ɁCRab^pN͂܂܂ȃugtBbNɂL[t@N^[ł邽߁CRab^pNꎩُ̂̈킾łȂC̊𐧌䂷^pNGtFN^[^pNُ̈͂܂܂ȎЂN<a href="#R52"><sup>52)</sup></a>D܂ŋ߂ł́Cah呤Rab^pNIɗp邱Ƃɂ芴𐬗Ă邱ƂȂǂ炩ɂȂĂĂ<a href="#R53"><sup>53)</sup></a>Dł́C̑\ЉD
@Rab^pNƂƂ̊֘A񍐂͐邪C悭ĂƂĂRab25DRab25Rab11ƗގĂiRab11CƂ΂邱ƂjCɂčĂDƂɁCRab25CLIC3ƋIɋ@\CGhTCg[VXꂽ51CeOTCNOĉipseudopodiajւƗADɂזËړ𑣐iCזE̓]ڂɊ֗^̂ƍlĂ<a href="#R54"><sup>54)</sup></a>D
@V̑\ƂẮCm\[̃AN`tBgɂAiAN`Aj𐧌䂷Rab27ACSlac2-aC~IVVaȂOҕ̂̂ꂩُ̈ɂFfُ̏ǏGriscelliǌQD~IVVäُ1^GriscelliǌQCRab27Äُ2^GriscelliǌQCSlac2-äُ3^GriscelliǌQ̌ƂȂ<a href="#R38"><sup>38)</sup></a>Dm\[̃AN`AɈُ킪ƁCm\[͔ǂAN`tBgւƎ󂯓nꂸCǂtsɂǂĂ܂j̋ߖTɋÏWi<a href="#F4">}4b</a>jD̂߁Cm\[̓mTCgאڂѕזE畆pזEւƎ󂯓nꂸɐFfُ̏ǏD܂C2^GriscelliǌQ͐Ffُɂ킦ƉuƂȂCRab27Am\[łȂCזEQTזED̕oɂ֗^Ă邽߂ł<a href="#R38"><sup>38)</sup></a>DقɂCRab3ACRab7CRab18CRab23CRab33BCRab38CRab39BȂǂ̕ψقɂqg}EXɂĎǂ邱ƂmĂCڍׂ͕QƂꂽ<a href="#R52"><sup>52)</sup></a>D
@VKɍꂽRab^pÑVyƂċ@\REP1Ɉُ킪ƁCV@ichoroideremiaj𔭏ǂD炭Cق̑gDREP2݂Iɋ@\Ă邽߁Ĉ悤Ɍ肳ꂽgDɂĎǂ̂ƎvD܂CRab^pÑVyłGDIɈُ킪XA_x؁iX-linked mental retardationj̏ǏDRab3̓VivXEɑ݂̕ɐ[邱ƂGDĨ^[QbǧƂRab3lĂCۂɁCRab3GAPɈُ킪Warburg MicroǌQMartsolfǌQƂ_oЂND
@a̗ƂẮCXeAہCsہCWIlہCTlہCN~WAۂȂǂ̐^׋ۂ̊ɂRab^pN̕񍐂邪<a href="#R53"><sup>53)</sup></a>C{Iɂ́Ch̍זEɎ荞܂ꂽ̐^׋ۂhRab^pNɂ͂炫C\\[͂߂ƂٕF@\炤܂܂ʂil̂łDƂ΁CHłЂNTlہi<em>Salmonella enterica</em> serovar TyphimuriumjGhTCg[VXɂ}Nt@[WȂǂɐNƁCGh\[̓ɂđB邪Ĉ܂܂ƁC̏E̓\\[ƗZTlۂ͏h傩r^ɂD[ƂɁC̏Eł̓\\[ɃN[gׂ_yfrĂD́CTl̂R[h^pNSifAɂCRab9ˑ̃}m[X6-_ễgXSWlbg[Nւ̋tsAjQC}m[X6-_ễTCNO}邱Ƃɂ胊\\[ɗAׂ_yfCƂIȐ헪ɂ̂ł<a href="#R55"><sup>55)</sup></a>D

<h2></h2>
@݂̂ƂCRab^pN͚Mɂ60ވȏ̃AC\tH[݂Dŏqׂ悤ɁCRab1Rab5͂߂̋@\̂悭Ă̂邪CRab^pN͂܂̋@\͂悭ĂȂD܂C܂Rab^pNɂāCΉGtFN^[^pNGEF邢GAP͓肳ĂȂ<a href="#R7"><sup>7,56)</sup></a>DāC@\mRab^pNɒڂCVGtFN^[^pNGEF邢GAPT̋@\̉𖾂ɎgނƂ́CugtBbN̐Vȋǖʂ\Ђ߂ĂDɏqׂRab12̋@\̔CȂ킿CTCNOGh\[烊\\[ɂȂoH̔Ȃǂ́C̍Dł͂Ȃƍl<a href="#R19"><sup>19,20)</sup></a>D̈ŁCRab5Rab27Ȃǂ̂悤ɁCЂƂRab^pNɕ̃GtFN^[^pN݂̑P[XDƂ΁Cm\[̃AN`A𐧌䂷Rab27ACSlac2-aC~IVVȃݍṕCזEɌqۂɂ́CRab27ASlp2-aƂ̑ݍpɕωD̃GtFN^[^pŇSlac2-aSlp2-aRab27Aɑ΂eäႢɂ肠x͐ł̂<a href="#R38"><sup>38)</sup></a>C{̂Ƃ͂悭킩ĂȂDāCЂƂRab^pNɑ΂镡̃GtFN^[^pN̎gǂ̂悤ɐ䂳Ă̂𖾂炩ɂł΁CugtBbN̘A̗IɌシ̂ƍlD̂߂ɂ́C^Rab^pN𐶍זEC[WO@ɂ荂𑜓xɌoZpC܂܂LpɂȂĂ̂Ɨ\z<a href="#R57"><sup>57)</sup></a>D

<h2> </h2>
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<li id="R10"><span class='au'>Sivars, U., Aivazian, D. & Pfeffer, S. R.</span>: <span class="ti">Yip3 catalyses the dissociation of endosomal Rab-GDI complexes.</span> <span class='so'>Nature, 425, 856-859 (2003)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/14574414" target="_blank">PubMed</a>]</span></li>
<li id="R11"><span class='au'>Fukuda, M.</span>: <span class="ti">Regulation of secretory vesicle traffic by Rab small GTPases.</span> <span class='so'>Cell. Mol. Life Sci., 65, 2801-2813 (2008)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/18726178" target="_blank">PubMed</a>]</span></li>
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<li id="R13"><span class='au'>Gorvel, J. P., Chavrier, P., Zerial, M. et al.</span>: <span class="ti">rab5 controls early endosome fusion in vitro.</span> <span class='so'>Cell, 64, 915-925 (1991)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/1900457" target="_blank">PubMed</a>]</span></li>
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<li id="R16"><span class='au'>Johansson, M., Rocha, N., Zwart, W. et al.</span>: <span class="ti">Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150<sup>Glued</sup>, ORP1L, and the receptor III spectrin.</span> <span class='so'>J. Cell Biol., 176, 459-471 (2007)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17283181" target="_blank">PubMed</a>]</span></li>
<li id="R17"><span class='au'>Weigert, R., Yeung, A. C., Li, J. et al.</span>: <span class="ti">Rab22a regulates the recycling of membrane proteins internalized independently of clathrin.</span> <span class='so'>Mol. Biol. Cell, 15, 3758-3770 (2004)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/15181155" target="_blank">PubMed</a>]</span></li>
<li id="R18"><span class='au'>Kawauchi, T., Sekine, K., Shikanai, M. et al.</span>: <span class="ti">Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-cadherin trafficking.</span> <span class='so'>Neuron, 67, 588-602 (2010)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/20797536" target="_blank">PubMed</a>]</span></li>
<li id="R19"><span class='au'>Matsui, T., Itoh, T. & Fukuda, M.</span>: <span class="ti">Small GTPase Rab12 regulates constitutive degradation of transferrin receptor.</span> <span class='so'>Traffic, 12, 1432-1443 (2011)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21718402" target="_blank">PubMed</a>]</span></li>
<li id="R20"><span class='au'>Matsui, T. & Fukuda, M.</span>: <span class="ti">Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4.</span> <span class='so'>EMBO Rep., 14, 450-457 (2013)[<a href="http://www.ncbi.nlm.nih.gov/pubmed/23478338" target="_blank">PubMed</a>]</span></li>
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</ol>
<div class="au-profile">
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<span class="author"> TFiNorihiko Ohbayashij</span>
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<strong>c iMitsunori Fukudaj</strong>
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</div>
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