MASCOT Search Results
Protein View: NP_001306125.1
protein S100-A8 isoform a [Homo sapiens]
LOCUS NP_001306125 117 aa linear PRI 01-DEC-2016
DEFINITION protein S100-A8 isoform a [Homo sapiens].
ACCESSION NP_001306125
VERSION NP_001306125.1
DBSOURCE REFSEQ: accession NM_001319196.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 117)
AUTHORS Schneider RK, Schenone M, Ferreira MV, Kramann R, Joyce CE,
Hartigan C, Beier F, Brummendorf TH, Germing U, Platzbecker U,
Busche G, Knuchel R, Chen MC, Waters CS, Chen E, Chu LP, Novina CD,
Lindsley RC, Carr SA and Ebert BL.
TITLE Rps14 haploinsufficiency causes a block in erythroid
differentiation mediated by S100A8 and S100A9
JOURNAL Nat. Med. 22 (3), 288-297 (2016)
PUBMED 26878232
REMARK GeneRIF: The frequency of S100A8+ cells in del(5q) myelodysplastic
syndrome human bone marrow positively correlates with disease
severity.
REFERENCE 2 (residues 1 to 117)
AUTHORS Singh K, Agrawal NK, Gupta SK, Sinha P and Singh K.
TITLE Increased expression of TLR9 associated with pro-inflammatory
S100A8 and IL-8 in diabetic wounds could lead to unresolved
inflammation in type 2 diabetes mellitus (T2DM) cases with impaired
wound healing
JOURNAL J. Diabetes Complicat. 30 (1), 99-108 (2016)
PUBMED 26525587
REMARK GeneRIF: Data suggest up-regulation of pro-inflammatory molecules
TLR9, S100A8, and IL-8 plus lower levels of CD11b+ CD33+ myeloid
cells may be involved in impairment of wound healing in type 2
diabetes leading to chronic ulcers, such as diabetic foot ulcers.
REFERENCE 3 (residues 1 to 117)
AUTHORS De Ponti A, Wiechert L, Schneller D, Pusterla T, Longerich T, Hogg
N, Vogel A, Schirmacher P, Hess J and Angel P.
TITLE A pro-tumorigenic function of S100A8/A9 in carcinogen-induced
hepatocellular carcinoma
JOURNAL Cancer Lett. 369 (2), 396-404 (2015)
PUBMED 26404752
REMARK GeneRIF: We found that tumor cell proliferation was diminished in
the absence of S100A8/A9, leading to significant reduction of tumor
size.
REFERENCE 4 (residues 1 to 117)
AUTHORS Kim TS, Kang YJ, Kim JY, Lee S, Lee WJ, Sohn Y and Lee HW.
TITLE Up-regulated S100 calcium binding protein A8 in Plasmodium-infected
patients correlates with CD4(+)CD25(+)Foxp3 regulatory T cell
generation
JOURNAL Malar. J. 14, 385 (2015)
PUBMED 26438270
REMARK GeneRIF: Treg cells suppress the activity of cytotoxic T cells,
which kill malaria parasites; therefore, the up-regulation of
S100A8 in malaria patients may contribute to pathogen immune escape
or tolerance.
Erratum:[Malar J. 2015;14:506. PMID: 26678292]
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 117)
AUTHORS Pham DL, Yoon MG, Ban GY, Kim SH, Kim MA, Ye YM, Shin YS and Park
HS.
TITLE Serum S100A8 and S100A9 Enhance Innate Immune Responses in the
Pathogenesis of Baker's Asthma
JOURNAL Int. Arch. Allergy Immunol. 168 (2), 138-146 (2015)
PUBMED 26745257
REMARK GeneRIF: Serum S100A8 and S100A9 Enhance Innate Immune Responses in
the Pathogenesis of Baker's Asthma
REFERENCE 6 (residues 1 to 117)
AUTHORS Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE and
Vandekerckhove J.
TITLE Microsequences of 145 proteins recorded in the two-dimensional gel
protein database of normal human epidermal keratinocytes
JOURNAL Electrophoresis 13 (12), 960-969 (1992)
PUBMED 1286667
REFERENCE 7 (residues 1 to 117)
AUTHORS Lemarchand P, Vaglio M, Mauel J and Markert M.
TITLE Translocation of a small cytosolic calcium-binding protein (MRP-8)
to plasma membrane correlates with human neutrophil activation
JOURNAL J. Biol. Chem. 267 (27), 19379-19382 (1992)
PUBMED 1326551
REFERENCE 8 (residues 1 to 117)
AUTHORS Schafer T, Sachse GE and Gassen HG.
TITLE The calcium-binding protein MRP-8 is produced by human pulmonary
tumor cells
JOURNAL Biol. Chem. Hoppe-Seyler 372 (1), 1-4 (1991)
PUBMED 2039599
REFERENCE 9 (residues 1 to 117)
AUTHORS Dorin JR, Emslie E and van Heyningen V.
TITLE Related calcium-binding proteins map to the same subregion of
chromosome 1q and to an extended region of synteny on mouse
chromosome 3
JOURNAL Genomics 8 (3), 420-426 (1990)
PUBMED 2149559
REFERENCE 10 (residues 1 to 117)
AUTHORS Wilkinson MM, Busuttil A, Hayward C, Brock DJ, Dorin JR and Van
Heyningen V.
TITLE Expression pattern of two related cystic fibrosis-associated
calcium-binding proteins in normal and abnormal tissues
JOURNAL J. Cell. Sci. 91 (PT 2), 221-230 (1988)
PUBMED 3267695
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BU935536.1 and BP209293.1.
Summary: The protein encoded by this gene is a member of the S100
family of proteins containing 2 EF-hand calcium-binding motifs.
S100 proteins are localized in the cytoplasm and/or nucleus of a
wide range of cells, and involved in the regulation of a number of
cellular processes such as cell cycle progression and
differentiation. S100 genes include at least 13 members which are
located as a cluster on chromosome 1q21. This protein may function
in the inhibition of casein kinase and as a cytokine. Altered
expression of this protein is associated with the disease cystic
fibrosis. Multiple transcript variants encoding different isoforms
have been found for this gene. [provided by RefSeq, Jan 2016].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BP209293.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1966682, SAMEA2142670
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..117
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21.3"
Protein 1..117
/product="protein S100-A8 isoform a"
/note="protein S100-A8; calgranulin A; cystic fibrosis
antigen; calprotectin L1L subunit; urinary stone protein
band A; leukocyte L1 complex light chain; migration
inhibitory factor-related protein 8"
/calculated_mol_wt=13401
Region 27..110
/region_name="calgranulins"
/note="Calgranulins: S-100 domain found in proteins
belonging to the Calgranulin subgroup of the S100 family
of EF-hand calcium-modulated proteins, including S100A8,
S100A9, and S100A12 . Note that the S-100 hierarchy, to
which this Calgranulin group belongs; cd05030"
/db_xref="CDD:240156"
Site order(27,33,35,41,65,67,92,100,102)
/site_type="other"
/note="dimerization interface [polypeptide binding]"
/db_xref="CDD:240156"
Site order(44,49,52,57,83,85,87,89,94)
/site_type="other"
/note="Ca2+ binding site [ion binding]"
/db_xref="CDD:240156"
Region <55..99
/region_name="EF-hand_7"
/note="EF-hand domain pair; pfam13499"
/db_xref="CDD:290234"
CDS 1..117
/gene="S100A8"
/gene_synonym="60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag;
MA387; MIF; MRP8; NIF; P8"
/coded_by="NM_001319196.1:116..469"
/note="isoform a is encoded by transcript variant 1"
/db_xref="GeneID:6279"
/db_xref="HGNC:HGNC:10498"
/db_xref="MIM:123885"