Mascot Search Results

Match to: gi|6754816 Score: 692
septin 2; neural precursor cell expressed, developmentally down-regulated gene 5 [Mus musculus]
Found in search of C:\sequest_txt\043_022604_4.txt

Nominal mass (Mr): 41526; Calculated pI value: 6.10
NCBI BLAST search of gi|6754816 against nr
Unformatted sequence string for pasting into other applications

Taxonomy: Mus musculus
Links to retrieve other entries containing this sequence from NCBI Entrez:
gi|1346679 from Mus musculus
gi|677953 from Mus musculus
gi|26389442 from Mus musculus

Variable modifications: Acetyl (N-term),Oxidation (M),Propionamide (C),Sulphone (M)
Cleavage by Trypsin: cuts C-term side of KR unless next residue is P
Sequence Coverage: 41%

Matched peptides shown in Bold Red

     1 MSKQQPTQFI NPETPGYVGF ANLPNQVHRK SVKKGFEFTL MVVGESGLGK 
    51 STLINSLFLT DLYPERIIPG AAEKIERTVQ IEASTVEIEE RGVKLRLTVV 
   101 DTPGYGDAIN CRDCFKTIIS YIDEQFERYL HDESGLNRRH IIDNRVHCCF 
   151 YFISPFGHGL KPLDVAFMKA IHNKVNIVPV IAKADTLTLK ERERLKKRIL 
   201 DEIEEHSIKI YHLPDAESDE DEDFKEQTRL LKASIPFSVV GSNQLIEAKG 
   251 KKVRGRLYPW GVVEVENPEH NDFLKLRTML ITHMQDLQEV TQDLHYENFR 
   301 SERLKRGGRK VENEDMNKDQ ILLEKEAELR RMQEMIARMQ AQMQMQMQGG 
   351 DSDSGALGQH V

  Residue Number  Increasing Mass  Decreasing Mass 

 Start - End   Observed  Mr(expt) Mr(calc)   Delta   Miss Sequence
    51 - 66      941.70  1881.38  1882.14    -0.77     0  STLINSLFLTDLYPER  (Ions score 58)
    67 - 74      798.61   797.61   797.95    -0.34     0  IIPGAAEK  (Ions score 32)
    78 - 91      802.75  1603.49  1603.75    -0.25     0  TVQIEASTVEIEER  (Ions score 84)
   117 - 128     757.99  1513.96  1513.67     0.29     0  TIISYIDEQFER  (Ions score 76)
   129 - 138     602.62  1203.23  1203.28    -0.05     0  YLHDESGLNR  (Ions score 67)
   175 - 183     477.21   952.40   952.21     0.19     0  VNIVPVIAK  (Ions score 48)
   184 - 190     761.62   760.61   760.89    -0.28     0  ADTLTLK  (Ions score 38)
   199 - 209     664.05  1326.09  1325.48     0.60     0  ILDEIEEHSIK  (Ions score 66)
   233 - 249     881.43  1760.85  1760.02     0.83     0  ASIPFSVVGSNQLIEAK  (Ions score 67)
   310 - 325     973.93  1945.84  1946.20    -0.36     2  KVENEDMNKDQILLEK  (Ions score 83)
   332 - 338     878.61   877.60   878.07    -0.47     0  MQEMIAR  (Ions score 35)
   339 - 361    1218.36  2434.70  2435.70    -1.00     0  MQAQMQMQMQGGDSDSGALGQHV  (Ions score 45)





LOCUS       NP_035021                361 aa            linear   ROD 23-JAN-2004
DEFINITION  septin 2; neural precursor cell expressed, developmentally
            down-regulated gene 5 [Mus musculus].
ACCESSION   NP_035021
VERSION     NP_035021.1  GI:6754816
DBSOURCE    REFSEQ: accession NM_010891.1
KEYWORDS    .
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
REFERENCE   1
  AUTHORS   Kinoshita,M., Field,C.M., Coughlin,M.L., Straight,A.F. and
            Mitchison,T.J.
  TITLE     Self- and actin-templated assembly of Mammalian septins
  JOURNAL   Dev. Cell 3 (6), 791-802 (2002)
   PUBMED   12479805
REFERENCE   2
  AUTHORS   Kinoshita,A., Noda,M. and Kinoshita,M.
  TITLE     Differential localization of septins in the mouse brain
  JOURNAL   J. Comp. Neurol. 428 (2), 223-239 (2000)
   PUBMED   11064363
REFERENCE   3
  AUTHORS   Kinoshita,A., Kinoshita,M., Akiyama,H., Tomimoto,H., Akiguchi,I.,
            Kumar,S., Noda,M. and Kimura,J.
  TITLE     Identification of septins in neurofibrillary tangles in Alzheimer's
            disease
  JOURNAL   Am. J. Pathol. 153 (5), 1551-1560 (1998)
   PUBMED   9811347
REFERENCE   4
  AUTHORS   Kinoshita,M., Kumar,S., Mizoguchi,A., Ide,C., Kinoshita,A.,
            Haraguchi,T., Hiraoka,Y. and Noda,M.
  TITLE     Nedd5, a mammalian septin, is a novel cytoskeletal component
            interacting with actin-based structures
  JOURNAL   Genes Dev. 11, 1353-1547 (1997)
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D49382.2.
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="1"
     Protein         1..361
                     /product="septin 2"
                     /function="cytoskeletal component interacting with
                     actin-based structures"
                     /note="neural precursor cell expressed, developmentally
                     down-regulated gene 5"
     Region          34..313
                     /region_name="Cell division protein"
                     /note="GTP_CDC"
                     /db_xref="CDD:7746"
     CDS             1..361
                     /gene="Sept2"
                     /coded_by="NM_010891.1:54..1139"
                     /note="go_function: GTP binding [goid 0005525] [evidence
                     IEA];
                     go_function: ATP binding [goid 0005524] [evidence ISS]
                     [pmid 12466851];
                     go_process: cytokinesis [goid 0016288] [evidence IEA];
                     go_process: cell cycle [goid 0007049] [evidence IEA];
                     go_process: cytokinesis [goid 0000910] [evidence IEA]"
                     /db_xref="GeneID:18000"
                     /db_xref="LocusID:18000"
                     /db_xref="MGI:97298"