Entity
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
csml-variable:Double
m11
0
infinite
0
--
csml-variable:Double
m12
0
infinite
0
--
LPS: LBP: CD14-S
--
e13
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m13
0
infinite
0
--
LPS: LBP: CD14-M
--
e14
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m14
0
infinite
0
--
LPS: LBP
--
e15
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m15
0
infinite
0
--
STU
--
e16
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m16
0
infinite
0
--
LPS: LBP: CD14-M: STU
--
e17
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m17
0
infinite
0
--
csml-variable:Double
m18
0
infinite
0
--
LPS: LBP: CD14-M: STU: PKC
--
e19
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
p50: p65
--
e20
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m20
0
infinite
0
--
p50: p65 {phosphorylated}
--
e21
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
p50: p65 {nucleus}
--
e22
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m22
0
infinite
0
--
TNF-alpha
--
e23
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m23
0
infinite
0
--
TNF-alpha
--
e24
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m24
0
infinite
0
--
IL-1
--
e25
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m25
0
infinite
0
--
IL-6
--
e26
cso30:c:mRNA
cso30:i:CC_Nucleolus
--
csml-variable:Double
m26
0
infinite
0
--
MDP
--
e27
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
csml-variable:Double
m27
0
infinite
0
--
csml-variable:Double
m28
0
infinite
0
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
csml-variable:Double
m30
0
infinite
0
--
csml-variable:Double
m31
0
infinite
0
--
p50:p50 {activated}
--
e32
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m32
0
infinite
0
--
csml-variable:Double
m33
0
infinite
0
--
csml-variable:Double
m34
0
infinite
0
--
p50: p50
--
e35
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m35
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
CD14-M
--
e5
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
CD14-S
--
e6
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m12*m11*0.1
nodelay
--
0
PMID: 9917872, 1916089 The LPS binding protein belongs to the acute-phase proteins, and during infection high concentration of the complex between LPS and its binding protein can be formed.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1
m22*0.1
nodelay
--
0
PMID: 9917872, 8330898 The LPS stimulated induction of NFkappaB in the nucleus is essential for expression of cytokine genes, such as TNF, IL-1 and IL-6, with the consequent transcription and translation of these genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c28 : 1
m22*0.1
nodelay
--
0
PMID: 9917872, 8330898 The LPS stimulated induction of NFkappaB in the nucleus is essential for expression of cytokine genes, such as TNF, IL-1 and IL-6, with the consequent transcription and translation of these genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c50 : 1
stoichiometry:c31 : 1
m27*0.1
nodelay
--
0
PMID: 9917872, 8482846 MDP was a potent inducer of TNF mRNA expression. PMID: 9917872 LPS stimulation in tolerant monocytes and macrophages consists of p50p50 homodimers that blocks transactivation of the TNF gene.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c33 : 1
m27*0.1
nodelay
--
0
PMID: 9917872, 9242715 MDP always results in identical circulation levels of TNF and IL-6.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c37 : 1
m25*0.1
nodelay
--
0
PMID: 9917872, 8330898 The LPS stimulated induction of NFkappaB in the nucleus is essential for expression of cytokine genes, such as TNF, IL-1 and IL-6, with the consequent transcription and translation of these genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c38 : 1
m26*0.1
nodelay
--
0
PMID: 9917872, 8330898 The LPS stimulated induction of NFkappaB in the nucleus is essential for expression of cytokine genes, such as TNF, IL-1 and IL-6, with the consequent transcription and translation of these genes. PMID: 9917872 Daily injection of LPS in rats resulted in a measurable increase in the release of TNF, IL-1beta and IL-6 after the first injection.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c39 : 1
m19*0.1
nodelay
--
0
PMID: 9917872 Daily injection of LPS in rats resulted in a measurable increase in the release of TNF, IL-1beta and IL-6 after the first injection.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
m30*0.1
nodelay
--
0
PMID: 9917872 Daily injection of LPS in rats resulted in a measurable increase in the release of TNF, IL-1beta and IL-6 after the first injection.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c43 : 1
m19*0.1
nodelay
--
0
PMID: 9917872 LPS stimulation in tolerant monocytes and macrophages consists of p50p50 homodimers that blocks transactivation of the TNF gene.1.LPS stimulation in tolerant monocytes and macrophages consists of p50p50 homodimers that blocks transactivation of the TNF gene.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c44 : 1
m19*0.1
nodelay
--
0
PMID: 9917872 LPS stimulation in tolerant monocytes and macrophages consists of p50p50 homodimers that blocks transactivation of the TNF gene.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m15*m6*0.1
nodelay
--
0
PMID: 9917872, 7537790 The complex of LPS/LPS-binding protein is bound to a soluble form of the CD14 receptor.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c49 : 1
stoichiometry:c48 : 1
m19*m35*0.1
nodelay
--
0
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1
m19*m20*0.1
nodelay
--
0
PMID: 9917872, 8330898 The LPS stimulated induction of NFkappaB in the nucleus is essential for expression of cytokine genes, such as TNF, IL-1 and IL-6, with the consequent transcription and translation of these genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c56 : 1
stoichiometry:c55 : 1
m21*m27*0.1
nodelay
--
0
PMID: 9917872, 8522354 MDP also results in induction of NFkappaB and its translocation in nucleus.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m5*m15*0.1
nodelay
--
0
PMID: 9917872 The next step in LPS-induced cell activation is the interaction between the LPS/LPS-binding protein complex to its CD14 receptor.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
m14*m16*0.1
nodelay
--
0
PMID: 9917872, 8330898 The LPS stimulated induction of NFkappaB in the nucleus is essential for expression of cytokine genes, such as TNF, IL-1 and IL-6, with the consequent transcription and translation of these genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m17*m18*0.1
nodelay
--
0
PMID: 9917872, 8330898 The LPS stimulated induction of NFkappaB in the nucleus is essential for expression of cytokine genes, such as TNF, IL-1 and IL-6, with the consequent transcription and translation of these genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c29 : 1
stoichiometry:c17 : 1
m20*m27*0.1
nodelay
--
0
PMID: 9917872, 8522354 MDP also results in induction of NFkappaB and its translocation in nucleus.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
m21*0.1
nodelay
--
0
PMID: 9917872, 8330898 The LPS stimulated induction of NFkappaB in the nucleus is essential for expression of cytokine genes, such as TNF, IL-1 and IL-6, with the consequent transcription and translation of these genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c51 : 1
stoichiometry:c21 : 1
m22*0.1
nodelay
--
0
PMID: 9917872, 8330898 The LPS stimulated induction of NFkappaB in the nucleus is essential for expression of cytokine genes, such as TNF, IL-1 and IL-6, with the consequent transcription and translation of these genes. PMID: 9917872 LPS stimulation in tolerant monocytes and macrophages consists of p50p50 homodimers that blocks transactivation of the TNF gene.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m23*0.1
nodelay
--
0
PMID: 9917872, 8330898 The LPS stimulated induction of NFkappaB in the nucleus is essential for expression of cytokine genes, such as TNF, IL-1 and IL-6, with the consequent transcription and translation of these genes. PMID: 9917872 Daily injection of LPS in rats resulted in a measurable increase in the release of TNF, IL-1beta and IL-6 after the first injection.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--