Entity
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
Zymosan:CD11b:CD18
--
e11
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m11
0
infinite
0
--
csml-variable:Double
m12
0
infinite
0
--
E.coli:CD11b:CD18
--
e13
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m13
0
infinite
0
--
iC3b
--
e14
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m14
0
infinite
0
--
iC3b:CD11b:CD18
--
e15
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m15
0
infinite
0
--
zymosan:CD11b{p}:CD18{p}
--
e16
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m16
0
infinite
0
--
csml-variable:Double
m17
0
infinite
0
--
csml-variable:Double
m18
0
infinite
0
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
LPS:CD11b:CD18
--
e20
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m20
0
infinite
0
--
lectin
--
e21
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m21
0
infinite
0
--
lectin:CD11b:CD18
--
e22
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m22
0
infinite
0
--
L-selectin
--
e23
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m23
0
infinite
0
--
L-selectin:CD11b:CD18
--
e24
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m24
0
infinite
0
--
csml-variable:Double
m25
0
infinite
0
--
glucans:CD11b:CD18
--
e26
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m26
0
infinite
0
--
MoAbOKM1
--
e27
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m27
0
infinite
0
--
tyrosine kinase
--
e28
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m28
0
infinite
0
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
csml-variable:Double
m30
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
CD11b:CD18
--
e5
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c26 : 1
stoichiometry:c3 : 1
m5*m6*0.1
nodelay
--
0
PMID: 8485905, 3040333 Both zymosan (cell wall extract from the yeast Saccharomyces cereviseae) and Escherichia coli bind to resting CR3 and promote the phagocytically active state of CR3. beta-glucan component of zymosan, was responsible for CR3-dependent responses to iC3b-opsonized zymosan. CR3-dependent responses to fl-glucan were blocked by the CR3 alpha chain-specific MoAb OKMI.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m5*m12*0.1
nodelay
--
0
PMID: 8485905 Both zymosan (cell wall extract from the yeast Saccharomyces cereviseae) and Escherichia coli bind to resting CR3 and promote the phagocytically active state of CR3.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m5*m14*0.1
nodelay
--
0
PMID: 8485905, 833545, 573303, 7430626, 7252421, 7049467 Fixed iC3b on sheep erythrocytes (EC3bi) binds avidly to neutrophil, monocyte, and NK cell CR3, but does not trigger any cytotoxic reaction.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c10 : 1
stoichiometry:c20 : 1
m17*m11*0.1
nodelay
--
0
PMID: 8485905, 1976698, 1673986 CR3 is capable of mediating phagocytosis following protein kinase C (PKC)-dependent activation. Blockade of both PMA- induced phagocytosis and homotypic aggregation by the PKC inhibitor staurosporine suggests a similar activation pathway for these two CR3-dependent functions. Neutrophil aggregation and phagocytosis of EC3bi induced by PMA were blocked by staurosporine suggested that a PKC-associated phosphorylation event was required for CR3 activation. beta-glucan derived from zymosan binds to CR3 and activates the receptor via a phosphorylation event involving both PKC and a tyrosine kinase.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c14 : 1
m19*m5*0.1
nodelay
--
0
PMID: 8485905, 3537192 Lipopolysaccharide (LPS) on E. coli appears to bind to CR3 at a distinct site from beta-glucan and also stimulates CR3-dependent phagocytosis.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1
m5*m21*0.1
nodelay
--
0
PMID: 8485905, 1682263 certain fimbriated strains of E. coli stimulate CR3- dependent phagocytosis by way of a mannose-specific lectin on the bacteria that binds to a carbohydrate on CR3.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c28 : 1
stoichiometry:c32 : 1
stoichiometry:c23 : 1
m23*m5*m17*0.1
nodelay
--
0
PMID: 8485905, 1383326, 3283242, 1976698 Neutrophil homotypic aggregation requires PKC for exposure of a CR3 binding site for a counter-receptor on other neutrophils recently shown to be L-selectin.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c22 : 1
m25*m5*0.1
nodelay
--
0
PMID: 8485905, 2579146 soluble glucans from barley or laminarin bound weakly to CR3.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c27 : 1
stoichiometry:c11 : 1
m28*m11*0.1
nodelay
--
0
PMID: 8485905 beta-glucan derived from zymosan binds to CR3 and activates the receptor via a phosphorylation event involving both PKC and a tyrosine kinase. glucan-induced phagocytosis of EC3bi is not only prevented by staurosporine,but it is also blocked by genistein or herbimycin A, two tyrosine kinase inhibitors.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--