Entity
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m14
10
infinite
0
TRANSPATH | MO000000058 |
--
MAPKs{active}
--
MO000000077
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m69
10
infinite
0
TRANSPATH | MO000000077 |
--
IKK-alpha:IKKbeta:IKKgamma
--
MO000000210
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m181
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000000210 |
--
TRAF6
--
MO000000212
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m183
10
infinite
0
InterPro | IPR001841 |
TRANSPATH | MO000000212 |
--
IRF-3
--
MO000007694
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m977
10
infinite
0
InterPro | IPR008984 |
TRANSPATH | MO000007694 |
--
IRF-7
--
MO000007702
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m980
10
infinite
0
TRANSPATH | MO000007702 |
--
MyD88
--
MO000016573
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1572
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000016573 |
--
TAK1
--
MO000016574
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1573
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000016574 |
--
Caspase-8
--
MO000016900
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1815
10
infinite
0
TRANSPATH | MO000016900 |
--
Caspase-10
--
MO000016906
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1821
10
infinite
0
TRANSPATH | MO000016906 |
--
TRAF3
--
MO000016963
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1872
10
infinite
0
InterPro | IPR001841 |
TRANSPATH | MO000016963 |
--
proCaspase-8
--
MO000017669
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2432
10
infinite
0
InterPro | IPR001309 |
TRANSPATH | MO000017669 |
--
proCaspase-10
--
MO000018276
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2932
10
infinite
0
InterPro | IPR001309 |
TRANSPATH | MO000018276 |
--
TBK1:IKK-i
--
MO000019331
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m3902
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000019331 |
--
IRAK-4
--
MO000039077
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m17258
10
infinite
0
TRANSPATH | MO000039077 |
--
dsRNA:TLR3:TRIF
--
MO000041437
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19305
10
infinite
0
TRANSPATH | MO000041437 |
--
dsRNA:TLR3
--
MO000041446
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19314
10
infinite
0
TRANSPATH | MO000041446 |
--
Cryopyrin
--
MO000116924
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m86033
10
infinite
0
TRANSPATH | MO000116924 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
IKK-alpha:IKKbeta:IKKgamma{active}
--
e11
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m12
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000000210 |
--
csml-variable:Double
m15
0
infinite
0
--
NF-kappaB{active}
--
e14
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m16
10
infinite
0
TRANSPATH | MO000000058 |
--
csml-variable:Double
m17
0
infinite
0
--
Type I IFN
--
e17
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m19
0
infinite
0
--
TBK1:IKK-i{active}
--
e18
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m20
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000019331 |
--
csml-variable:Double
m21
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
IRF-3{active}
--
e20
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m22
10
infinite
0
InterPro | IPR008984 |
TRANSPATH | MO000007694 |
--
dsRNA:TLR3{p}
--
e21
cso30:c:Protein
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m23
0
infinite
0
--
dsRNA:TLR3{p}:PI3K
--
e22
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m24
0
infinite
0
--
DDX58:dsRNA
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
TLR9:CpG DNA
--
e26
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m29
0
infinite
0
--
DDX58:ssRNA
--
e27
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m30
0
infinite
0
--
IFIH1:dsRNA
--
e28
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m31
0
infinite
0
--
Poly-IC
--
e29
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m32
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
IFIH1:Poly-IC
--
e30
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m33
0
infinite
0
--
DDX58:dsRNA:MAVS
--
e31
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m34
0
infinite
0
--
IFIH1:dsRNA:MAVS
--
e32
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m35
0
infinite
0
--
DDX58:dsRNA:MAVS:TRAF3
--
e33
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m36
0
infinite
0
--
IFIH1:dsRNA:MAVS:TRAF3
--
e34
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m37
0
infinite
0
--
TLR9:CpG DNA:MyD88
--
e35
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m38
0
infinite
0
--
Viral RNA:TLR7
--
e36
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m39
0
infinite
0
--
Viral RNA:TLR7:MyD88
--
e37
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m40
0
infinite
0
--
TLR7:Viral RNA:MyD88:IRAK1:IRAK4:TRAF3:TRAF6:IKK-alpha:IRF-7
--
e39
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m42
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
TLR9:CpG DNA:MyD88:IRAK1:IRAK4:TRAF3:TRAF6:IKK-alpha:IRF-7
--
e40
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m43
0
infinite
0
--
Cytokines
--
e41
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m44
0
infinite
0
--
IRF-7{active}
--
e42
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m46
10
infinite
0
TRANSPATH | MO000007702 |
--
Cryopyrin:ssRNA
--
e44
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m48
0
infinite
0
--
Cryopyrin:dsRNA
--
e45
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m49
0
infinite
0
--
Caspase-1{active}
--
e47
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m64
10
infinite
0
TRANSPATH | MO000016828 |
--
--
e48
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_
--
--
--
csml-variable:Double
m65
0
infinite
0
--
--
e49
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_
--
--
--
csml-variable:Double
m66
0
infinite
0
--
dsRNA:TLR3:TRIF:TRAF3:TRAF6:RIP1:RIP3
--
e5
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
TAK1{active}
--
e6
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m11
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000016574 |
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e63
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulumLumen
--
--
--
csml-variable:Double
m67
0
infinite
0
--
--
e64
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_Membrane_
--
--
--
csml-variable:Double
m68
0
infinite
0
--
--
e65
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_
--
--
--
csml-variable:Double
m70
0
infinite
0
--
--
e66
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum
--
--
--
csml-variable:Double
m71
0
infinite
0
--
UNC93B1
--
e69
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m74
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
IFIH1:dsRNA:MAVS:FADD
--
e70
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m75
0
infinite
0
--
DDX58:dsRNA:MAVS:FADD
--
e71
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m76
0
infinite
0
--
TLR7:Viral RNA:MyD88:IRAK1:IRAK4:TRAF3:TRAF6:IKK-alpha
--
e72
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m77
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
p1
p1
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m3965*m119368*0.1
nodelay
--
0
PMID: 18694646,12471095,12539043 TLR3 recognizes double-stranded (ds)RNA and triggers a signaling pathway via a TIR domain-containing adapter inducing IFN-beta (TRIF) (also known as TICAM-1)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c96 : 1
stoichiometry:c114 : 1
m29*m1572*0.1
nodelay
--
0
PMID: 18694646 TLR9 shares the adapter protein MyD88 and the downstream signaling pathway with TLR7.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
m16*0.1
nodelay
--
0
PMID: 18694646 TRIF associates with TRAF3, TRAF6 and RIP1. TRAF6 and RIP1 activate NF-KappaB and AP-1 while TRAF3 activates TBK1/IKK-i and is followed by a type I IFN response.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
m18*0.1
nodelay
--
0
PMID: 18694646 TRIF associates with TRAF3, TRAF6 and RIP1. TRAF6 and RIP1 activate NF-KappaB and AP-1 while TRAF3 activates TBK1/IKK-i and is followed by a type I IFN response.
p4
p13
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1
m5*m3902*0.1
nodelay
--
0
PMID: 18694646 Figure 1 PMID: 18694646 TRAF6 and RIP1 activate NF-KappaB while TRAF3 activates TRAF family member-associated NK-KappaB activator (TANK)-binding kinase 1 (TBK1) and inducible IKappaB kinase (IKK-i).
p14
p14
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c29 : 1
m5*m977*0.1
nodelay
--
0
--
p37
p15
cso30:i:ME_Binding
cso30:i:CC_EndosomeLumen
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c119 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1
m38*m17258*m1872*m183*m184*m41*m980*0.1
nodelay
--
0
PMID: 18694646,16306937,15767370,15361868 Upon exposure to its ligand, MyD88 forms a complex with interleukin-1-receptor (IL-1R)-associated kinase-4 (IRAK-4), IRAK-1, tumor necrosis factor-receptor associated factor 3 (TRAF3), TRAF6, Ikkalpha and IRF-7
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
m22*0.1
nodelay
--
0
PMID: 18694646 TRIF associates with TRAF3, TRAF6 and RIP1. TRAF6 and RIP1 activate NF-KappaB and AP-1 while TRAF3 activates TBK1/IKK-i and is followed by a type I IFN response.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
m19314*0.1
nodelay
--
0
PMID:18694646 Tyrosine phosphorylation of TLR3 induces PI3K recruitment to the receptor and subsequent activation of Akt leads to activation of IRF-3.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1
m23*m27*0.1
nodelay
--
0
--
p19
p19
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1
m24*m45*0.1
nodelay
--
0
PMID:18694646 Tyrosine phosphorylation of TLR3 induces PI3K recruitment to the receptor and subsequent activation of Akt leads to activation of IRF-3.
p1
p2
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m18998*m19314*0.1
nodelay
--
0
PMID: 18694646,12471095,12539043 TLR3 recognizes double-stranded (ds)RNA and triggers a signaling pathway via a TIR domain-containing adapter inducing IFN-beta (TRIF) (also known as TICAM-1)
p19
p20
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c26 : 1
m25*m977*0.1
nodelay
--
0
PMID:18694646 Tyrosine phosphorylation of TLR3 induces PI3K recruitment to the receptor and subsequent activation of Akt leads to activation of IRF-3.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1
m26*m41844*0.1
nodelay
--
0
PMID: 18694646,18242112,17038589 RIG-I binds 5prime-triphosphorylated single-stranded (ss)RNA and short dsRNA and stimulates production of type I IFNs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c31 : 1
stoichiometry:c62 : 1
m41844*m15*0.1
nodelay
--
0
PMID: 18694646,18242112,17038589 RIG-I binds 5prime-triphosphorylated single-stranded (ss)RNA and short dsRNA and stimulates production of type I IFNs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1
m76904*m26*0.1
nodelay
--
0
PMID: 18694646,16625202 By contrast, MDA5 preferentially recognizes longer-dsRNA, including synthetic poly-IC
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1
m76904*m32*0.1
nodelay
--
0
PMID: 18694646,16625202 By contrast, MDA5 preferentially recognizes longer-dsRNA, including synthetic poly-IC
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1
m28*m68199*0.1
nodelay
--
0
PMID: 18694646,16127453,16125763,16177806,16153868 Both RIG-I and MDA5 associate with an adapter protein IPS-1 also known as MAVS, VISA or CARDIF, which also contains an N-terminal CARD
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c184 : 1
stoichiometry:c73 : 1
m31*m68199*0.1
nodelay
--
0
PMID: 18694646,16127453,16125763,16177806,16153868 Both RIG-I and MDA5 associate with an adapter protein IPS-1 also known as MAVS, VISA or CARDIF, which also contains an N-terminal CARD
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1
m34*m1872*0.1
nodelay
--
0
PMID: 18694646 IPS-1 then associates with TRAF3, followed by activation of TBK1 and Ikk-i.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1
m1872*m35*0.1
nodelay
--
0
PMID: 18694646 IPS-1 then associates with TRAF3, followed by activation of TBK1 and Ikk-i.
p29
p29
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1
m36*m3902*0.1
nodelay
--
0
PMID: 18694646 IPS-1 then associates with TRAF3, followed by activation of TBK1 and Ikk-i.
p3
p3
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c9 : 1
m19305*m1872*m183*m6*m3825*0.1
nodelay
--
0
PMID: 18694646,14530355,15064760 TRIF associates with TRAF3 and TRAF6 via TRAF-binding motifs which exist in its N-terminal portion and also with receptor interacting protein (RIP) 1 and RIP3 via RIP homotypic interaction motif (RHIM)
p29
p30
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1
m37*m3902*0.1
nodelay
--
0
PMID: 18694646 IPS-1 then associates with TRAF3, followed by activation of TBK1 and Ikk-i.
p31
p31
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1
m20*m977*0.1
nodelay
--
0
PMID: 18694646,15210742,15800576 These kinases phosphorylate IRF3 and IRF7 and induce type I IFN production
p31
p32
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
m20*m980*0.1
nodelay
--
0
PMID: 18694646,15210742,15800576 These kinases phosphorylate IRF3 and IRF7 and induce type I IFN production
p33
p33
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
m19324*0.1
nodelay
--
0
PMID: 18694646,15210742,15800576 These kinases phosphorylate IRF3 and IRF7 and induce type I IFN production
p33
p34
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
m19325*0.1
nodelay
--
0
PMID: 18694646,15210742,15800576 These kinases phosphorylate IRF3 and IRF7 and induce type I IFN production
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c41 : 1
stoichiometry:c98 : 1
m19940*m17*0.1
nodelay
--
0
PMID: 18694646 Figure 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1
m39*m1572*0.1
nodelay
--
0
PMID: 18694646 TLR7 signals through a TIR domain-containing adapter, myeloid differentiation factor 88 (MyD88).
p37
p37
cso30:i:ME_Binding
cso30:i:CC_EndosomeLumen
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1
m40*m184*m17258*m1872*m183*m41*m980*0.1
nodelay
--
0
PMID: 18694646,16306937,15767370,15361868 Upon exposure to its ligand, MyD88 forms a complex with interleukin-1-receptor (IL-1R)-associated kinase-4 (IRAK-4), IRAK-1, tumor necrosis factor-receptor associated factor 3 (TRAF3), TRAF6, Ikkalpha and IRF-7
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
m16*0.1
nodelay
--
0
PMID: 18694646 Following the formation of this signaling complex, IRF7 and nuclear factor-kappa B (NF-¦ÊB) are activated, which results in the production of type I IFNs and cytokines
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c30 : 1
stoichiometry:c185 : 1
m42*0.1
nodelay
--
0
PMID: 18694646 Following the formation of this signaling complex, IRF7 and nuclear factor-kappa B (NF-¦ÊB) are activated, which results in the production of type I IFNs and cytokines PMID: 18694646 Figure 2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m5*m1573*0.1
nodelay
--
0
PMID: 18694646 Figure 1 PMID: 18694646 TRAF6 and RIP1 activate NF-KappaB while TRAF3 activates TRAF family member-associated NK-KappaB activator (TANK)-binding kinase 1 (TBK1) and inducible IKappaB kinase (IKK-i).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c116 : 1
m46*0.1
nodelay
--
0
PMID: 18694646 Following the formation of this signaling complex, IRF7 and nuclear factor-kappa B (NF-¦ÊB) are activated, which results in the production of type I IFNs and cytokines
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
m16*0.1
nodelay
--
0
PMID: 18694646 Following the formation of this signaling complex, IRF7 and nuclear factor-kappa B (NF-¦ÊB) are activated, which results in the production of type I IFNs and cytokines
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
m46*0.1
nodelay
--
0
PMID: 18694646 Following the formation of this signaling complex, IRF7 and nuclear factor-kappa B (NF-¦ÊB) are activated, which results in the production of type I IFNs and cytokines
p43
p43
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1
m42*m1573*0.1
nodelay
--
0
PMID: 18694646 Figure 1
p44
p44
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1
m43*m1573*0.1
nodelay
--
0
PMID: 18694646 Figure2
p45
p45
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1
m43*m970*0.1
nodelay
--
0
PMID: 18694646,17273999 cDCs and macrophages also respond to CpG-DNA and produce small amounts of IFN-beta through IRF-1 activation rather than IRF-3 or IRF-7 activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
m47*0.1
nodelay
--
0
PMID: 18694646,17273999 cDCs and macrophages also respond to CpG-DNA and produce small amounts of IFN-beta through IRF-1 activation rather than IRF-3 or IRF-7 activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1
m86033*m15*0.1
nodelay
--
0
PMID: 18694646,17008311,16407888 Cryopyrin/NALP3 was shown to recognize both ssRNA and dsRNA of viral origin or their synthetic versions and to induce caspase-1 activation via apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1
m86033*m26*0.1
nodelay
--
0
PMID: 18694646,17008311,16407888 Cryopyrin/NALP3 was shown to recognize both ssRNA and dsRNA of viral origin or their synthetic versions and to induce caspase-1 activation via apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC)
p49
p49
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1
m48*m21736*0.1
nodelay
--
0
PMID: 18694646,17008311,16407888 Cryopyrin/NALP3 was shown to recognize both ssRNA and dsRNA of viral origin or their synthetic versions and to induce caspase-1 activation via apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1
m181*m11*0.1
nodelay
--
0
PMID: 18694646 Figure 1 PMID: 18694646 TRAF6 and RIP1 activate NF-KappaB while TRAF3 activates TRAF family member-associated NK-KappaB activator (TANK)-binding kinase 1 (TBK1) and inducible IKappaB kinase (IKK-i).
p49
p50
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1
m49*m21736*0.1
nodelay
--
0
PMID: 18694646,17008311,16407888 Cryopyrin/NALP3 was shown to recognize both ssRNA and dsRNA of viral origin or their synthetic versions and to induce caspase-1 activation via apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC)
p49
p51
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1
m63*m1765*0.1
nodelay
--
0
PMID: 18694646,17008311,16407888 Cryopyrin/NALP3 was shown to recognize both ssRNA and dsRNA of viral origin or their synthetic versions and to induce caspase-1 activation via apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c156 : 1
m73*m74*0.1
nodelay
--
0
PMID: 18694646,18305481 Recently endoplasmic reticulum (ER) protein UNC93B1 turned out to be essential for trafficking of TLR7 and TLR9 from ER to endosome,but what triggers this TLR-trafficking from ER to endosome before viral recognition by TLRs remains to be elucidated.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c159 : 1
stoichiometry:c158 : 1
m72*m74*0.1
nodelay
--
0
PMID: 18694646,18305481 Recently endoplasmic reticulum (ER) protein UNC93B1 turned out to be essential for trafficking of TLR7 and TLR9 from ER to endosome,but what triggers this TLR-trafficking from ER to endosome before viral recognition by TLRs remains to be elucidated.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1
m35*m1814*0.1
nodelay
--
0
PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c164 : 1
stoichiometry:c165 : 1
m34*m1814*0.1
nodelay
--
0
PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10
p56
p56
cso30:i:ME_Cleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c168 : 1
m75*m2432*0.1
nodelay
--
0
PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10
p56
p57
cso30:i:ME_Cleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1
m76*m2432*0.1
nodelay
--
0
PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10
p56
p58
cso30:i:ME_Cleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1
m76*m2932*0.1
nodelay
--
0
PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10
p56
p59
cso30:i:ME_Cleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1
m75*m2932*0.1
nodelay
--
0
PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
m11*m13*0.1
nodelay
--
0
PMID: 18694646 Figure 1 PMID: 18694646 TRAF6 and RIP1 activate NF-KappaB while TRAF3 activates TRAF family member-associated NK-KappaB activator (TANK)-binding kinase 1 (TBK1) and inducible IKappaB kinase (IKK-i). PMID: 18694646 Figure 2
p60
p60
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1
m1815*m14*0.1
nodelay
--
0
PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10
p60
p61
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1
m1821*m14*0.1
nodelay
--
0
PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10
p4
p7
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m12*m14*0.1
nodelay
--
0
PMID: 18694646 Figure 1 PMID: 18694646 TRAF6 and RIP1 activate NF-KappaB while TRAF3 activates TRAF family member-associated NK-KappaB activator (TANK)-binding kinase 1 (TBK1) and inducible IKappaB kinase (IKK-i). PMID: 18694646 Following the formation of this signaling complex, IRF7 and nuclear factor-kappa B (NF-¦ÊB) are activated, which results in the production of type I IFNs and cytokines PMID: 18694646 Figure 2
p4
p8
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c25 : 1
m69*m219*0.1
nodelay
--
0
PMID: 18694646 Figure 1 PMID: 18694646 TRAF6 and RIP1 activate NF-KappaB while TRAF3 activates TRAF family member-associated NK-KappaB activator (TANK)-binding kinase 1 (TBK1) and inducible IKappaB kinase (IKK-i) PMID: 18694646 Figure 2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c56 : 1
m19828*m21*0.1
nodelay
--
0
PMID: 18694646 TLR9 recognizes unmethylated DNA with a CpG motif (CpG-DNA) and DNA viruses, including herpes simplex virus (HSV)-1, HSV-2 and cytomegalovirus (CMV) in pDCs.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--