Entity
p38
--
MO000000022
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m33
10
infinite
0
TRANSPATH | MO000000022 |
--
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m53
10
infinite
0
TRANSPATH | MO000000058 |
--
IKK-alpha:IKK-beta:Nemo
--
MO000000210
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m181
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000000210 |
--
Caspase-1
--
MO000016828
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1765
10
infinite
0
TRANSPATH | MO000016828 |
--
proIL-1beta
--
MO000019449
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m4012
10
infinite
0
InterPro | IPR003297 |
TRANSPATH | MO000019449 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
Nod1{oligo}:PGN
--
e11
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m11
0
infinite
0
--
Nod2{oligo}:PGN
--
e12
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m12
0
infinite
0
--
Nod1{oligo}:PGN:RIP2
--
e13
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m13
0
infinite
0
--
Nod2{oligo}:PGN:RIP2
--
e14
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m14
0
infinite
0
--
Nod1{oligo}:PGN:RIP2{ub}
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m15
0
infinite
0
--
Nod2{oligo}:PGN:RIP2{ub}
--
e16
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m16
0
infinite
0
--
Nod1{oligo}:PGN:RIP2{ub}:TAK1
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
Nod2{oligo}:PGN:RIP2{ub}:TAK1
--
e18
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
Nod1{oligo}:PGN:RIP2{ub}:TAK1:IKK
--
e29
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
Nod2{oligo}:PGN:RIP2{ub}:TAK1:IKK
--
e30
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m30
0
infinite
0
--
Nod1{oligo}:PGN:RIP2{ub}:TAK1:IKK{active}
--
e31
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m31
0
infinite
0
--
Nod2{oligo}:PGN:RIP2{ub}:TAK1:IKK{active}
--
e32
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m32
0
infinite
0
--
Nod2:CARD9
--
e35
cso30:c:Complex
cso30:i:CC_Cell
--
--
csml-variable:Double
m35
0
infinite
0
--
L.momocytogenes
--
e36
cso30:c:Cell
cso30:i:CC_Cell
--
--
csml-variable:Double
m36
0
infinite
0
--
NF-kappaB{active}
--
e37
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m37
10
infinite
0
TRANSPATH | MO000000058 |
--
p38{p}
--
e39
cso30:c:Protein
cso30:i:CC_Cell
--
--
csml-variable:Double
m42
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
TLR
--
e40
cso30:c:Complex
cso30:i:CC_Cell
--
--
csml-variable:Double
m43
0
infinite
0
--
Caspase-1{active}
--
e41
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m44
10
infinite
0
TRANSPATH | MO000016828 |
--
NLRC4
--
e42
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m45
0
infinite
0
--
csml-variable:Double
m46
0
infinite
0
--
Nod1:PGN
--
e5
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m5
0
infinite
0
--
Nod2:PGN
--
e6
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m6
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m155701*m4923*0.1
nodelay
--
0
PMID: 18585455,12796777,12791997 NOD1 activity is triggered by g-Dglutamyl- meso-diaminopimelic acid (meso-DAP) 1), which is unique to PGN structures from all Gram-negative bacteria and certain Gram-positive bacteria, including the genus Listeria and Bacillus
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1
m15*m1573*0.1
nodelay
--
0
PMID: 18585455 K63-linked regulatory ubiquitination of RICK leads to the recruitment of TAK1. PMID: 18585455,18079694,18342009 Similar to TLR signaling, recent studies have demonstrated that K63-linked regulatory ubiquitination of RICK is essential for the recruitment of TAK1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1
m16*m1573*0.1
nodelay
--
0
PMID: 18585455 K63-linked regulatory ubiquitination of RICK leads to the recruitment of TAK1. PMID: 18585455,18079694,18342009 Similar to TLR signaling, recent studies have demonstrated that K63-linked regulatory ubiquitination of RICK is essential for the recruitment of TAK1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
m17*m181*0.1
nodelay
--
0
PMID: 18585455 The activation and recruitment of TAK1 complex to RICK further recruits the IKK complex
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1
m18*m181*0.1
nodelay
--
0
PMID: 18585455 The activation and recruitment of TAK1 complex to RICK further recruits the IKK complex
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
m29*0.1
nodelay
--
0
PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
m30*0.1
nodelay
--
0
PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1
p14
p16
cso30:i:ME_UnknownActivation
cso30:i:CC_Cell
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c47 : 1
stoichiometry:c55 : 1
m31*m33*0.1
nodelay
--
0
PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1 PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1
m15*m1585*0.1
nodelay
--
0
PMID: 18585455,18079694,18342009 As in the case of TLRs, this modification can be removed by the deubiquitinating enzyme A20, thus dampening NOD1/NOD2-induced NF-kB activation
p18
p18
cso30:i:ME_Binding
cso30:i:CC_Cell
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1
m4947*m21914*m36*0.1
nodelay
--
0
PMID: 18585455 Recently it was demonstrated that ectopically expressed CARD9, an essential protein in antifungal responses and TLR signaling, interacts with NOD2 after challenge with L. monocytogenes.
p19
p19
cso30:i:ME_UnknownActivation
cso30:i:CC_Cell
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1
m31*m53*0.1
nodelay
--
0
PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m155701*m4947*0.1
nodelay
--
0
PMID: 18585455,12527755,12514169 In contrast, NOD2 is activated by muramyl dipeptide (MDP), a peptidogylcan motif present in all Gram-positive and Gram-negative bacteria
p19
p20
cso30:i:ME_UnknownActivation
cso30:i:CC_Cell
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c46 : 1
m32*m53*0.1
nodelay
--
0
PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs
p14
p21
cso30:i:ME_UnknownActivation
cso30:i:CC_Cell
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1
m31*m34*0.1
nodelay
--
0
PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1 PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs
p14
p22
cso30:i:ME_UnknownActivation
cso30:i:CC_Cell
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1
m31*m38*0.1
nodelay
--
0
PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1 PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs
p14
p23
cso30:i:ME_UnknownActivation
cso30:i:CC_Cell
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1
m32*m38*0.1
nodelay
--
0
PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1 PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs
p14
p24
cso30:i:ME_UnknownActivation
cso30:i:CC_Cell
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1
m32*m34*0.1
nodelay
--
0
PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1 PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs
p14
p25
cso30:i:ME_UnknownActivation
cso30:i:CC_Cell
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1
m32*m33*0.1
nodelay
--
0
PMID: 18585455 The interaction between RICK and NEMO ultimately results in the activation of IKKs and MKK by TAK1 PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c74 : 1
m16*m1585*0.1
nodelay
--
0
PMID: 18585455,18079694,18342009 As in the case of TLRs, this modification can be removed by the deubiquitinating enzyme A20, thus dampening NOD1/NOD2-induced NF-kB activation
p27
p27
cso30:i:ME_Phosphorylation
cso30:i:CC_Cell
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c78 : 1
stoichiometry:c77 : 1
m33*m21914*0.1
nodelay
--
0
PMID: 18585455,17187069 Furthermore, CARD9-deficient macrophages exhibited impaired phosphorylation of p38 after MDP stimulation, suggesting that CARD9 is another essential intermediate in the NOD2-signaling cascade that acts downstream of TAK1
p28
p28
cso30:i:ME_UnknownActivation
cso30:i:CC_Cell
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1
m53*m43*0.1
nodelay
--
0
PMID: 18585455,17433728 TLR-mediated NF-kB is required for the production of pro-IL-1b while the cleavage of pro-IL-1b into its biologically active form is dependent on NLR-mediated caspase-1 activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
m37*0.1
nodelay
--
0
PMID: 18585455,17433728 TLR-mediated NF-kB is required for the production of pro-IL-1b while the cleavage of pro-IL-1b into its biologically active form is dependent on NLR-mediated caspase-1 activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
m5*0.1
nodelay
--
0
PMID: 18585455 Upon ligand recognition, NOD1 and NOD2 undergo conformational changes and selfoligomerization.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c89 : 1
stoichiometry:c85 : 1
m4012*m44*0.1
nodelay
--
0
PMID: 18585455,17433728 TLR-mediated NF-kB is required for the production of pro-IL-1b while the cleavage of pro-IL-1b into its biologically active form is dependent on NLR-mediated caspase-1 activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c86 : 1
stoichiometry:c88 : 1
m1765*m5*0.1
nodelay
--
0
PMID: 18585455,17433728 TLR-mediated NF-kB is required for the production of pro-IL-1b while the cleavage of pro-IL-1b into its biologically active form is dependent on NLR-mediated caspase-1 activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c99 : 1
stoichiometry:c92 : 1
m1765*m6*0.1
nodelay
--
0
PMID: 18585455,17433728 TLR-mediated NF-kB is required for the production of pro-IL-1b while the cleavage of pro-IL-1b into its biologically active form is dependent on NLR-mediated caspase-1 activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
m45*m1765*0.1
nodelay
--
0
PMID: 18585455 NLRC4 has been demonstrated to mediate caspase-1 activation, independent of TLR5, following cytosolic delivery of flagellin. PMID: 18585455 Various intracellular bacteria have the ability to activate caspase-1 in a NLRC4-dependent manner
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1
m46*m1765*0.1
nodelay
--
0
PMID: 18585455 NLRP3 mediates activation of caspase-1 in response to a variety of structurally unrelated stimuli, not limiting to those of bacterial origin.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
m6*0.1
nodelay
--
0
PMID: 18585455 Upon ligand recognition, NOD1 and NOD2 undergo conformational changes and selfoligomerization.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1
m2684*m11*0.1
nodelay
--
0
PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c16 : 1
stoichiometry:c15 : 1
m2684*m12*0.1
nodelay
--
0
PMID: 18585455,10880512,11463746,17277144,17579072 This is followed by the recruitment and activation of the serine threonine kinase RICK (RIP2), essential for the activation of NF-kB and MAPKs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1
m13*m180*0.1
nodelay
--
0
PMID: 18585455 Although, both NOD1 and NOD2 induce similar K63-linked ubiquitination of RICK for NF-kB activation, Nod2-signaling appears to preferentially utilize the E3 ligase TRAF6, whereas TRAF2 and TRAF5 were shown to be important for NOD1-mediated signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1
m13*m1874*0.1
nodelay
--
0
PMID: 18585455 Although, both NOD1 and NOD2 induce similar K63-linked ubiquitination of RICK for NF-kB activation, Nod2-signaling appears to preferentially utilize the E3 ligase TRAF6, whereas TRAF2 and TRAF5 were shown to be important for NOD1-mediated signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1
m14*m183*0.1
nodelay
--
0
PMID: 18585455 Although, both NOD1 and NOD2 induce similar K63-linked ubiquitination of RICK for NF-kB activation, Nod2-signaling appears to preferentially utilize the E3 ligase TRAF6, whereas TRAF2 and TRAF5 were shown to be important for NOD1-mediated signaling.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--