Entity
proIL-18
--
MO000007330
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m841
10
infinite
0
InterPro | IPR008996 |
TRANSPATH | MO000007330 |
--
IL-1beta
--
MO000016597
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1591
10
infinite
0
TRANSPATH | MO000016597 |
--
IL-18
--
MO000016625
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1611
10
infinite
0
InterPro | IPR008996 |
TRANSPATH | MO000016625 |
--
Caspase-1
--
MO000016828
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1765
10
infinite
0
TRANSPATH | MO000016828 |
--
proIL-1beta
--
MO000019449
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m4012
10
infinite
0
InterPro | IPR003297 |
TRANSPATH | MO000019449 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
csml-variable:Double
m11
0
infinite
0
--
NALP3 inflammasome {activated}
--
e12
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m12
0
infinite
0
--
csml-variable:Double
m13
0
infinite
0
--
NALP1B inflammasome {activated}
--
e14
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m14
0
infinite
0
--
IPAF inflammasome {activated}
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m15
0
infinite
0
--
NALP3 inflammasome {activated}: ASC
--
e16
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m16
0
infinite
0
--
NAIP5 inflammasome {activated}: ASC
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
NALP3 inflammasome {activated}: ASC: caspase-1 {activated}
--
e18
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
IPAF inflammasome {activated}: ASC
--
e19
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
NAIP5 inflammasome {activated}
--
e20
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m20
0
infinite
0
--
IL-1beta {extracellular}
--
e21
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m21
10
infinite
0
TRANSPATH | MO000016597 |
--
IL-1R: IL-1beta
--
e22
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m22
0
infinite
0
--
NALP3 inflammasome {activated}: ASC: caspase-1
--
e23
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
NAIP5 inflammasome {activated}: ASC: caspase-1
--
e24
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m24
0
infinite
0
--
NAIP5 inflammasome {activated}: ASC: caspase-1{activated}
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m25
0
infinite
0
--
IPAF inflammasome {activated}: ASC: caspase-1
--
e26
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m26
0
infinite
0
--
IPAF inflammasome {activated}: ASC: caspase-1{activated}
--
e28
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
anthrax lethal toxin
--
e29
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
listeriolysin O toxin
--
e30
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m31
0
infinite
0
--
bacterial protein
--
e31
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m32
0
infinite
0
--
Mycobacterium tuberculosis protein
--
e32
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m33
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c55 : 1
stoichiometry:c2 : 1
m5*m31*0.1
nodelay
--
0
PMID: 18407061 Vacuolar escape and listeriolysin O toxin were required for NALP3 inflammasome activation by Listeria monocytogenes.
p10
p10
cso30:i:ME_ProteinCleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c50 : 1
stoichiometry:c24 : 1
m841*m28*0.1
nodelay
--
0
PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.
p11
p11
cso30:i:ME_ProteinCleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c53 : 1
stoichiometry:c26 : 1
m4012*m28*0.1
nodelay
--
0
PMID: 18407061 Inflammasome activation results in IL-1beta processing and release of IL-1beta that is followed by the engagement of its receptor (IL-1R).
p12
p12
cso30:i:ME_Translocation
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
m1591*0.1
nodelay
--
0
PMID: 18407061 Inflammasome activation results in IL-1beta processing and release of IL-1beta that is followed by the engagement of its receptor (IL-1R).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1
m21*m27*0.1
nodelay
--
0
PMID: 18407061 Inflammasome activation results in IL-1beta processing and release of IL-1beta that is followed by the engagement of its receptor (IL-1R).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c40 : 1
stoichiometry:c33 : 1
m16*m1765*0.1
nodelay
--
0
PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c41 : 1
stoichiometry:c35 : 1
m17*m1765*0.1
nodelay
--
0
PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c37 : 1
m24*0.1
nodelay
--
0
PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c43 : 1
stoichiometry:c39 : 1
m19*m1765*0.1
nodelay
--
0
PMID; 18407061 Infection with M. tuberculosis triggers IPAF inflammasome including the adaptor ASC and caspase-1 (Casp-1).
p18
p18
cso30:i:ME_ProteinCleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c49 : 1
stoichiometry:c45 : 1
m841*m25*0.1
nodelay
--
0
PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.
p19
p19
cso30:i:ME_ProteinCleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1
m841*m18*0.1
nodelay
--
0
PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c54 : 1
stoichiometry:c4 : 1
m13*m29*0.1
nodelay
--
0
PMID: 18407061 Bacillus anthracis uses anthrax lethal toxin to activate a NALP1b inflammasome.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c42 : 1
m26*0.1
nodelay
--
0
PMID; 18407061 Infection with M. tuberculosis triggers IPAF inflammasome including the adaptor ASC and caspase-1 (Casp-1).
p21
p21
cso30:i:ME_ProteinCleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c52 : 1
stoichiometry:c59 : 1
m4012*m25*0.1
nodelay
--
0
PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.
p22
p22
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c65 : 1
stoichiometry:c64 : 1
m30*m1591*0.1
nodelay
--
0
PMID: 18407061 IL-1beta is known to activate PI3K, and it is tempting to speculate that the IL-1R signaling pathway and phagosome maturation pathway may converge at PI3K activation to promote PI3P generation.
p23
p23
cso30:i:ME_ProteinCleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c51 : 1
stoichiometry:c63 : 1
m4012*m18*0.1
nodelay
--
0
PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c9 : 1
stoichiometry:c17 : 1
m21736*m12*0.1
nodelay
--
0
PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c10 : 1
stoichiometry:c18 : 1
m21736*m20*0.1
nodelay
--
0
PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c36 : 1
m23*0.1
nodelay
--
0
PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c12 : 1
stoichiometry:c20 : 1
m21736*m15*0.1
nodelay
--
0
PMID; 18407061 Infection with M. tuberculosis triggers IPAF inflammasome including the adaptor ASC and caspase-1 (Casp-1).
p7
p7
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c57 : 1
stoichiometry:c14 : 1
m11*m6485*0.1
nodelay
--
0
PMID: 18407061, 17126540 IPAF and ASC have been previously associated with inflammasome activation by the Gram-negative bacteria Salmonella typhimurium, Shigella flexneri, and Pseudomonas aeruginosa, which use their type III secretion system to inject IPAF activators such as flagellin in the cytosol of macrophages.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c60 : 1
stoichiometry:c16 : 1
m11*m33*0.1
nodelay
--
0
PMID; 18407061 Infection with M. tuberculosis triggers IPAF inflammasome including the adaptor ASC and caspase-1 (Casp-1).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c56 : 1
stoichiometry:c22 : 1
m6*m32*0.1
nodelay
--
0
PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--