_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e3
_enti_e2
_enti_e4
_enti_e74
_enti_e55
_enti_e73
_enti_e75
_enti_e53
_enti_e59
_enti_e50
_enti_e52
_enti_e54
_enti_e56
_enti_e51
_enti_e58
_enti_e57
_enti_e61
_enti_e60
_enti_e62
g1_fact_g2
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
p1_propro_p1
PMID: 18406369
Hematopoietic cytokines act on membrane-bound receptors that lack kinase activity themselves.
c1 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 18406369
However, the receptor chains are tightly associated with janus kinases (JAKs)
c4 cso30:c:InputProcess connector
c3 cso30:c:InputProcess connector
c2 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 18406369,10071751
Upon binding of cytokines, these receptors aggregate and perform conformational changes that lead to autoactivation of the JAKs
c9 cso30:c:InputProcess connector
c10 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 18406369,10071751
Upon binding of cytokines, these receptors aggregate and perform conformational changes that lead to autoactivation of the JAKs
c7 cso30:c:InputProcess connector
c8 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 18406369
In turn, JAKs induce tyrosine phosphorylation within the receptor chains and this generates docking sites for signal transducer and activator of transcription factors (STATs)
c11 cso30:c:InputProcess connector
c106 cso30:c:InputInhibitor connector
c137 cso30:c:InputInhibitor connector
c138 cso30:c:InputInhibitor connector
c12 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 18406369
According to recent research data , Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activationinactivation cycle, , STATs are found as pre-associated homo- or heterodimers in an anti-parallel conformation.
c13 cso30:c:InputProcess connector
c14 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 18406369
In turn, JAKs induce tyrosine phosphorylation within the receptor chains and this generates docking sites for signal transducer and activator of transcription factors (STATs)
PMID: 18406369
Upon cytokine receptor stimulation, STAT dimers change their conformation towards a parallel one and bind to tyrosine-phosphorylated cytokine receptor chains by use of their Src homology 2 (SH2) domain.
PMID: 18406369
In turn, SOCS2 and CIS interfere with STAT recruitment
PMID: 18406369
SOCS2 and CIS are assumed to mainly act by competition with STAT factors for recruitment to the activated receptor complex.
c15 cso30:c:InputProcess connector
c16 cso30:c:InputProcess connector
c93 cso30:c:InputInhibitor connector
c94 cso30:c:InputInhibitor connector
c17 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 18406369
In turn, STATs are tyrosine phosphorylated by JAKs, which uncovers a nuclear localization signal.
c18 cso30:c:InputProcess connector
c19 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 18406369
STAT dimers dissociate from the receptor and translocate to the nucleus where they act as transcription factors by binding to specific DNA sequences.
c20 cso30:c:InputProcess connector
c22 cso30:c:OutputProcess connector
c21 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 18406369
STAT dimers dissociate from the receptor and translocate to the nucleus where they act as transcription factors by binding to specific DNA sequences.
c23 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 18406369
STAT dimers dissociate from the receptor and translocate to the nucleus where they act as transcription factors by binding to specific DNA sequences.
c25 cso30:c:InputProcess connector
c26 cso30:c:InputProcess connector
c27 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 18406369
STAT dimers dissociate from the receptor and translocate to the nucleus where they act as transcription factors by binding to specific DNA sequences.
c28 cso30:c:InputAssociation connector
c29 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 18406369
CIS also plays a role in limiting GM-CSF, IL-2, prolactin and growth hormone signaling by inhibition of STAT5 activation.
c30 cso30:c:InputProcess connector
c32 cso30:c:InputInhibitor connector
c31 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 18406369,9826711
Similar results were obtained for LPS-mediated activation of TLR4
c33 cso30:c:InputProcess connector
c34 cso30:c:InputProcess connector
c35 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 18406369
In the case of TLR2 and 4 this association is facilitated by TIR domain-containing adaptor/MyD88-adaptor-like protein (TIRAP/Mal).
c36 cso30:c:InputProcess connector
c119 cso30:c:InputProcess connector
c38 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 18406369
With the exception of TLR3 all TLRs use myeloid differentiation factor 88 (MyD88) as a central adaptor.
c39 cso30:c:InputProcess connector
c40 cso30:c:InputProcess connector
c41 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 18406369
The net result is that the MyD88-dependent pathway activates MAP kinases and the NFκB signaling module
c43 cso30:c:InputProcess connector
c42 cso30:c:InputAssociation connector
c44 cso30:c:OutputProcess connector
p17_propro_p18
PMID: 18406369
The net result is that the MyD88-dependent pathway activates MAP kinases and the NFκB signaling module
c45 cso30:c:InputAssociation connector
c46 cso30:c:InputProcess connector
c47 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 18406369
The net result is that the MyD88-dependent pathway activates MAP kinases and the NFκB signaling module
c48 cso30:c:InputAssociation connector
c49 cso30:c:OutputProcess connector
p19_propro_p20
PMID: 18406369
The net result is that the MyD88-dependent pathway activates MAP kinases and the NFκB signaling module
c129 cso30:c:InputAssociation connector
c51 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 18406369
TLR3 and TLR4 further bind to TIR domain-containing protein inducing IFN-β (TRIF) and the latter TLR therefore uses TRIF-related adaptor molecule in addition.
c53 cso30:c:InputProcess connector
c150 cso30:c:InputProcess connector
c54 cso30:c:OutputProcess connector
p21_propro_p22
PMID: 18406369
TLR3 and TLR4 further bind to TIR domain-containing protein inducing IFN-β (TRIF) and the latter TLR therefore uses TRIF-related adaptor molecule in addition.
c55 cso30:c:InputProcess connector
c56 cso30:c:InputProcess connector
c57 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 18406369
TRIF in contrast mainly activates IRF3, thereby inducing IFN-β, which in turn can signal in an autocrine or paracrine manner.
c58 cso30:c:InputAssociation connector
c59 cso30:c:InputProcess connector
c60 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 18406369
TRIF in contrast mainly activates IRF3, thereby inducing IFN-β, which in turn can signal in an autocrine or paracrine manner.
c61 cso30:c:InputAssociation connector
c62 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 18406369,11390452
Using murine macrophages and DCs, we were the first to show that triggering of TLR9 by CpG-DNA resulted in induction of SOCS1 and SOCS3
c63 cso30:c:InputProcess connector
c64 cso30:c:InputProcess connector
c65 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 18406369,11390452
Using murine macrophages and DCs, we were the first to show that triggering of TLR9 by CpG-DNA resulted in induction of SOCS1 and SOCS3
c66 cso30:c:InputAssociation connector
c68 cso30:c:InputAssociation connector
c110 cso30:c:OutputProcess connector
p26_propro_p27
PMID: 18406369,11390452
Using murine macrophages and DCs, we were the first to show that triggering of TLR9 by CpG-DNA resulted in induction of SOCS1 and SOCS3
c69 cso30:c:InputAssociation connector
c70 cso30:c:InputAssociation connector
c80 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 18406369,9826711
Similar results were obtained for LPS-mediated activation of TLR4
c73 cso30:c:InputAssociation connector
c152 cso30:c:InputAssociation connector
c112 cso30:c:OutputProcess connector
p29_propro_p29
c75 cso30:c:InputProcess connector
c76 cso30:c:InputProcess connector
c77 cso30:c:OutputProcess connector
p28_propro_p30
PMID: 18406369,9826711
Similar results were obtained for LPS-mediated activation of TLR4
c79 cso30:c:InputAssociation connector
c153 cso30:c:InputAssociation connector
c111 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 18406369,11727828,10606755
Moreover, it turned out that also MAP-kinase activation itself The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription, or stimulation with TNF was able to induce SOCS3
c81 cso30:c:InputAssociation connector
c82 cso30:c:InputAssociation connector
c67 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 18406369
In turn, SOCS2 and CIS interfere with STAT recruitment
PMID: 18406369
SOCS2 and CIS are assumed to mainly act by competition with STAT factors for recruitment to the activated receptor complex.
c87 cso30:c:InputProcess connector
c88 cso30:c:InputProcess connector
c89 cso30:c:OutputProcess connector
p33_propro_p34
PMID: 18406369
In turn, SOCS2 and CIS interfere with STAT recruitment
PMID: 18406369
SOCS2 and CIS are assumed to mainly act by competition with STAT factors for recruitment to the activated receptor complex.
c90 cso30:c:InputProcess connector
c91 cso30:c:InputProcess connector
c92 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 18406369
In contrast, SOCS1 and SOCS3 are reported to inhibit JAK activity by use of their KIR domain
PMID: 18406369
However, although it has been suggested that SOCS1 directly binds to JAK2 and acts as a pseudosubstrate, it was shown that SOCS3 binds to cytokine receptor chains with special affinity for gp130.
c95 cso30:c:InputProcess connector
c98 cso30:c:InputProcess connector
c97 cso30:c:OutputProcess connector
p35_propro_p36
PMID: 18406369
In contrast, SOCS1 and SOCS3 are reported to inhibit JAK activity by use of their KIR domain
PMID: 18406369
However, although it has been suggested that SOCS1 directly binds to JAK2 and acts as a pseudosubstrate, it was shown that SOCS3 binds to cytokine receptor chains with special affinity for gp130.
c102 cso30:c:InputProcess connector
c114 cso30:c:InputProcess connector
c104 cso30:c:OutputProcess connector
p35_propro_p37
PMID: 18406369
In contrast, SOCS1 and SOCS3 are reported to inhibit JAK activity by use of their KIR domain
PMID: 18406369
However, although it has been suggested that SOCS1 directly binds to JAK2 and acts as a pseudosubstrate, it was shown that SOCS3 binds to cytokine receptor chains with special affinity for gp130.
c99 cso30:c:InputProcess connector
c100 cso30:c:InputProcess connector
c96 cso30:c:OutputProcess connector
p35_propro_p38
PMID: 18406369
In contrast, SOCS1 and SOCS3 are reported to inhibit JAK activity by use of their KIR domain
PMID: 18406369
However, although it has been suggested that SOCS1 directly binds to JAK2 and acts as a pseudosubstrate, it was shown that SOCS3 binds to cytokine receptor chains with special affinity for gp130.
c105 cso30:c:InputProcess connector
c107 cso30:c:InputProcess connector
c108 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 18406369,12811837
In a further study, we showed that not only various TLR ligands but also whole bacteria were able to stimulate rapid production of SOCS1, -3 and CIS
c71 cso30:c:InputAssociation connector
c74 cso30:c:InputAssociation connector
c83 cso30:c:OutputProcess connector
p39_propro_p40
PMID: 18406369,12811837
In a further study, we showed that not only various TLR ligands but also whole bacteria were able to stimulate rapid production of SOCS1, -3 and CIS
c85 cso30:c:InputAssociation connector
c103 cso30:c:InputAssociation connector
c115 cso30:c:OutputProcess connector
p39_propro_p41
PMID: 18406369,12811837
In a further study, we showed that not only various TLR ligands but also whole bacteria were able to stimulate rapid production of SOCS1, -3 and CIS
c116 cso30:c:InputAssociation connector
c117 cso30:c:InputAssociation connector
c118 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 18406369,16287972
Recent data furthermore suggest that TLR4 stimulation might activate JAK2, thereby becoming sensitive to SOCS1
c120 cso30:c:InputProcess connector
c154 cso30:c:InputAssociation connector
c121 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 18406369,16415872
Meanwhile, another group suggested that TIRAP/Mal becomes poly-ubiquitinated and degraded by SOCS1, resulting in prolonged NFκB signaling
c123 cso30:c:InputProcess connector
c127 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 18406369,16415872
Meanwhile, another group suggested that TIRAP/Mal becomes poly-ubiquitinated and degraded by SOCS1, resulting in prolonged NFκB signaling
c126 cso30:c:InputAssociation connector
c122 cso30:c:InputProcess connector
c37 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 18406369
The net result is that the MyD88-dependent pathway activates MAP kinases and the NFκB signaling module
c50 cso30:c:InputProcess connector
c128 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 18406369
Interestingly, recent results suggested that SOCS1 might be found within the nucleus where it could interact with NFκB
c130 cso30:c:InputProcess connector
c131 cso30:c:InputProcess connector
c132 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 18406360,12076535
It was shown that the SOCS-box associates with Elongin B and C and together with cullin-2 and Rbx1 builds up an ECS-type E3 ubiquitin ligase
c134 cso30:c:InputProcess connector
c133 cso30:c:InputProcess connector
c135 cso30:c:OutputProcess connector
p35_propro_p48
PMID: 18406369
In contrast, SOCS1 and SOCS3 are reported to inhibit JAK activity by use of their KIR domain
PMID: 18406369
However, although it has been suggested that SOCS1 directly binds to JAK2 and acts as a pseudosubstrate, it was shown that SOCS3 binds to cytokine receptor chains with special affinity for gp130.
c101 cso30:c:InputProcess connector
c109 cso30:c:InputProcess connector
c136 cso30:c:OutputProcess connector
p47_propro_p49
PMID: 18406360,12076535
It was shown that the SOCS-box associates with Elongin B and C and together with cullin-2 and Rbx1 builds up an ECS-type E3 ubiquitin ligase
c139 cso30:c:InputProcess connector
c140 cso30:c:InputProcess connector
c141 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 18406369,11727828,10606755
Moreover, it turned out that also MAP-kinase activation itself The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription, or stimulation with TNF was able to induce SOCS3
c84 cso30:c:InputAssociation connector
c86 cso30:c:OutputProcess connector
p50_propro_p50
PMISD: 18406369
Moreover, it turned out that also MAP-kinase activation itself The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription, or stimulation with TNF was able to induce SOCS3
c113 cso30:c:InputProcess connector
c142 cso30:c:InputProcess connector
c143 cso30:c:OutputProcess connector
p51_propro_p51
PMISD: 18406369
Moreover, it turned out that also MAP-kinase activation itself The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription, or stimulation with TNF was able to induce SOCS3
c144 cso30:c:InputAssociation connector
c146 cso30:c:InputInhibitor connector
c145 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 18406369
Moreover, MAP-kinase and NFκB activation were not affected, yet STAT1 tyrosine phosphorylation upon TLR triggering was inhibited.
c147 cso30:c:InputInhibitor connector
c148 cso30:c:InputProcess connector
c151 cso30:c:InputAssociation connector
c149 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 18406369
n turn, homo- (TLR3, 4, 9) or heterodimers (TLR1, 2, 6) are activated and associate with intracellular adaptor molecules.
c72 cso30:c:InputProcess connector
c78 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 18406369
microbial stimuli directly bind to TLRs, which results in conformational changes.
c52 cso30:c:InputProcess connector
c125 cso30:c:InputProcess connector
c155 cso30:c:OutputProcess connector
p54_propro_p55
PMID: 18406369
TLR3 and TLR4 further bind to TIR domain-containing protein inducing IFN-β (TRIF) and the latter TLR therefore uses TRIF-related adaptor molecule in addition.
c158 cso30:c:InputProcess connector
c162 cso30:c:InputProcess connector
c163 cso30:c:OutputProcess connector
p23_propro_p56
PMID: 18406369
TRIF in contrast mainly activates IRF3, thereby inducing IFN-β, which in turn can signal in an autocrine or paracrine manner.
c159 cso30:c:InputAssociation connector
c160 cso30:c:InputProcess connector
c161 cso30:c:OutputProcess connector
p53_propro_p57
PMID: 18406369
n turn, homo- (TLR3, 4, 9) or heterodimers (TLR1, 2, 6) are activated and associate with intracellular adaptor molecules.
c156 cso30:c:InputProcess connector
c157 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 18406369
In turn, homo- (TLR3, 4, 9) or heterodimers (TLR1, 2, 6) are activated and associate with intracellular adaptor molecules.
c164 cso30:c:InputProcess connector
c165 cso30:c:InputProcess connector
c166 cso30:c:OutputProcess connector
p58_propro_p59
PMID: 18406369
In turn, homo- (TLR3, 4, 9) or heterodimers (TLR1, 2, 6) are activated and associate with intracellular adaptor molecules.
c167 cso30:c:InputProcess connector
c168 cso30:c:InputProcess connector
c169 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 18406369
microbial stimuli directly bind to TLRs, which results in conformational changes.
c170 cso30:c:InputProcess connector
c171 cso30:c:InputProcess connector
c172 cso30:c:OutputProcess connector
p60_propro_p61
PMID: 18406369
microbial stimuli directly bind to TLRs, which results in conformational changes.
c173 cso30:c:InputProcess connector
c174 cso30:c:InputProcess connector
c175 cso30:c:OutputProcess connector
p15_propro_p62
PMID: 18406369
In the case of TLR2 and 4 this association is facilitated by TIR domain-containing adaptor/MyD88-adaptor-like protein (TIRAP/Mal).
c177 cso30:c:InputProcess connector
c178 cso30:c:InputProcess connector
c124 cso30:c:OutputProcess connector
p15_propro_p63
PMID: 18406369
In the case of TLR2 and 4 this association is facilitated by TIR domain-containing adaptor/MyD88-adaptor-like protein (TIRAP/Mal).
c176 cso30:c:InputProcess connector
c179 cso30:c:InputProcess connector
c180 cso30:c:OutputProcess connector
p16_propro_p64
PMID: 18406369
With the exception of TLR3 all TLRs use myeloid differentiation factor 88 (MyD88) as a central adaptor.
c181 cso30:c:InputProcess connector
c183 cso30:c:InputProcess connector
c185 cso30:c:OutputProcess connector
p16_propro_p65
PMID: 18406369
With the exception of TLR3 all TLRs use myeloid differentiation factor 88 (MyD88) as a central adaptor.
c182 cso30:c:InputProcess connector
c184 cso30:c:InputProcess connector
c186 cso30:c:OutputProcess connector
p17_propro_p66
PMID: 18406369
The net result is that the MyD88-dependent pathway activates MAP kinases and the NFκB signaling module
c187 cso30:c:InputAssociation connector
c193 cso30:c:InputProcess connector
c194 cso30:c:OutputProcess connector
p17_propro_p67
PMID: 18406369
The net result is that the MyD88-dependent pathway activates MAP kinases and the NFκB signaling module
c189 cso30:c:InputAssociation connector
c197 cso30:c:InputProcess connector
c198 cso30:c:OutputProcess connector
p17_propro_p68
PMID: 18406369
The net result is that the MyD88-dependent pathway activates MAP kinases and the NFκB signaling module
c188 cso30:c:InputAssociation connector
c191 cso30:c:InputProcess connector
c192 cso30:c:OutputProcess connector
p17_propro_p69
PMID: 18406369
The net result is that the MyD88-dependent pathway activates MAP kinases and the NFκB signaling module
c190 cso30:c:InputAssociation connector
c195 cso30:c:InputProcess connector
c196 cso30:c:OutputProcess connector
p53_propro_p70
PMID: 18406369
n turn, homo- (TLR3, 4, 9) or heterodimers (TLR1, 2, 6) are activated and associate with intracellular adaptor molecules.
c199 cso30:c:InputProcess connector
c200 cso30:c:OutputProcess connector
p16_propro_p71
PMID: 18406369
With the exception of TLR3 all TLRs use myeloid differentiation factor 88 (MyD88) as a central adaptor.
c201 cso30:c:InputProcess connector
c202 cso30:c:InputProcess connector
c203 cso30:c:OutputProcess connector
p17_propro_p72
PMID: 18406369
The net result is that the MyD88-dependent pathway activates MAP kinases and the NFκB signaling module
c204 cso30:c:InputAssociation connector
c205 cso30:c:InputProcess connector
c206 cso30:c:OutputProcess connector
p17_propro_p73
PMID: 18406369
The net result is that the MyD88-dependent pathway activates MAP kinases and the NFκB signaling module
c207 cso30:c:InputAssociation connector
c208 cso30:c:InputProcess connector
c209 cso30:c:OutputProcess connector
p74_propro_p74
PMID: 18406369,15021916
It was reported that human papilloma virus (HPV) E7 protein could be degraded by SOCS expression, resulting in a loss of proliferation of HPV-transformed HeLa cells
c210 cso30:c:InputProcess connector
c212 cso30:c:InputAssociation connector
c211 cso30:c:OutputProcess connector
Cytokine_enti_e5
Cytokine
Receptor_enti_e6
Receptor
Receptor:JAKs_enti_e13
Receptor:JAKs
STATs_enti_MO000016656
STATs
cytokine:Receptor:JAKs_enti_e11
cytokine:Receptor:JAKs
cytokine:Receptor:Jaks_enti_e14
cytokine:Receptor:Jaks
cytokine:Receptor:Jaks{active}_enti_e15
cytokine:Receptor:Jaks{active}
cytokine:Receptor{pY}:Jaks{active}_enti_e16
cytokine:Receptor{pY}:Jaks{active}
STAT dimer_enti_e17
STAT dimer
Cytokine:receptor{pY}:JAKs{active}:STATs_enti_e18
Cytokine:receptor{pY}:JAKs{active}:STATs
Cytokine:receptor{pY}:JAKs:STATs{p}_enti_e19
Cytokine:receptor{pY}:JAKs:STATs{p}
STAT{p} dimer_enti_e20
STAT{p} dimer
DNA:STATdimer_enti_e21
DNA:STATdimer
DNA_enti_e22
DNA
mRNA_enti_e23
mRNA
STAT5_enti_MO000016876
STAT5
CIS_enti_MO000017116
CIS
STAT5{active}_enti_e24
STAT5{active}
LPS_enti_MO000016882
LPS
TLR4_enti_MO000019394
TLR4
LPS:TLR4_enti_e25
LPS:TLR4
TIRAP_enti_MO000022528
TIRAP
MyD88_enti_MO000016573
MyD88
LPS:TLR4:TIRAP_enti_e26
LPS:TLR4:TIRAP
LPS:TLR4:TIRAP:MyD88_enti_e27
LPS:TLR4:TIRAP:MyD88
MAPKs_enti_MO000000077
MAPKs
MAPKs{active}_enti_e28
MAPKs{active}
NF-kappaB_enti_MO000000058
NF-kappaB
NF-kappaB{active}_enti_e29
NF-kappaB{active}
proinflammatory cytokines_enti_e30
proinflammatory cytokines
TRAM_enti_MO000041132
TRAM
LPS:TLR4:TRAM_enti_e31
LPS:TLR4:TRAM
TRIF_enti_MO000041125
TRIF
LPS:TLR4:TRAM:TRIF_enti_e32
LPS:TLR4:TRAM:TRIF
IRF-3_enti_MO000007694
IRF-3
IRF-3{active}_enti_e33
IRF-3{active}
IFN-beta_enti_e34
IFN-beta
TLR9_enti_MO000042012
TLR9
CpGmotif_enti_e35
CpGmotif
TLR9:CpGmotif_enti_e36
TLR9:CpGmotif
SOCS1_enti_G010539
SOCS1
SOCS3_enti_G011948
SOCS3
TNF-alpha_enti_MO000000289
TNF-alpha
TNF-alpha receptor_enti_e39
TNF-alpha receptor
TNF-alpha:receptor_enti_e40
TNF-alpha:receptor
SOCS-1_enti_MO000017004
SOCS-1
SOCS-2_enti_MO000017120
SOCS-2
SOCS-3_enti_MO000017121
SOCS-3
SOCS-1:JAKs_enti_e43
SOCS-1:JAKs
SHP-2_enti_MO000016886
SHP-2
SOCS-3:SHP-2_enti_e45
SOCS-3:SHP-2
Cytokine:receptor{pY}:JAKs {active}:SOCS-3:SHP-2_enti_e46
Cytokine:receptor{pY}:JAKs {active}:SOCS-3:SHP-2
Bacteria_enti_e37
Bacteria
CIS_enti_e38
CIS
Jak2_enti_MO000000146
Jak2
Jak2{active}_enti_e12
Jak2{active}
dergradants_enti_e48
NF-kappaB{active}_enti_e49
NF-kappaB{active}
SOCS-1_enti_e63
SOCS-1
NF-KappaB{active}:SOCS-1_enti_e64
NF-KappaB{active}:SOCS-1
elongin B_enti_MO000018947
elongin B
SOCS:Elongin B_enti_e65
SOCS:Elongin B
JaKs_enti_e66
JaKs
Cytokine:receptor{pY}:JAKs{active}:SOCS-2_enti_e42
Cytokine:receptor{pY}:JAKs{active}:SOCS-2
Cytokine:receptor{pY}:JAKs{active}:CIS_enti_e67
Cytokine:receptor{pY}:JAKs{active}:CIS
SOCS-1:JAK2:Receptor_enti_e41
SOCS-1:JAK2:Receptor
Cytokine:receptor{pY}:JAKs {active}:SOCS-3_enti_e44
Cytokine:receptor{pY}:JAKs {active}:SOCS-3
SOCS_enti_e68
SOCS
elongin C_enti_MO000018946
elongin C
SOCS:ElonginC_enti_e69
SOCS:ElonginC
IL-6_enti_MO000007384
IL-6
IL-6R_enti_MO000018458
IL-6R
IL-6:IL-6R_enti_e70
IL-6:IL-6R
STAT1_enti_MO000013119
STAT1
STAT1{pY}_enti_e71
STAT1{pY}
LPS(2):TLR4(2)_enti_e72
LPS(2):TLR4(2)
TLR3_enti_MO000019398
TLR3
microbacterial stimuli_enti_e76
microbacterial stimuli
TLR3:microbacterial stimuli_enti_e77
TLR3:microbacterial stimuli
TLR3:miccrobial stimuli:TRIF_enti_e78
TLR3:miccrobial stimuli:TRIF
TLR2_enti_MO000019397
TLR2
TLR1_enti_MO000019396
TLR1
TLR6_enti_MO000019422
TLR6
microbial stimuli:TLR3(2)_enti_e79
microbial stimuli:TLR3(2)
TLR2:TLR1_enti_e80
TLR2:TLR1
TLR2:TLR6_enti_e81
TLR2:TLR6
TLR2:TLR1:microbial stimuli_enti_e82
TLR2:TLR1:microbial stimuli
TLR2:TLR6:microbial stimuli_enti_e83
TLR2:TLR6:microbial stimuli
TIRAP{ub}_enti_e47
TIRAP{ub}
TLR2:TLR1:microbial stimuli:TIRAP_enti_e84
TLR2:TLR1:microbial stimuli:TIRAP
TLR2:TLR6:microbial stimuli:TIRAP_enti_e85
TLR2:TLR6:microbial stimuli:TIRAP
TLR2:TLR1:microbial stimuli:TIRAP:MyD88_enti_e86
TLR2:TLR1:microbial stimuli:TIRAP:MyD88
TLR2:TLR6:microbial stimuli:TIRAP:MyD88_enti_e87
TLR2:TLR6:microbial stimuli:TIRAP:MyD88
CpGmotif:TLR9(2)_enti_e89
CpGmotif:TLR9(2)
CpGmotif:TLR9(2):MyD88_enti_e90
CpGmotif:TLR9(2):MyD88
HPV-E7_enti_e88
HPV-E7
STAT{p} dimer_enti_e91
STAT{p} dimer