Entity
SOCS3
--
G011948
cso30:c:mRNA
cso30:i:CC_CellComponent
--
csml-variable:Double
m94757
10
infinite
0
TRANSFAC | G011948 |
--
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m29
10
infinite
0
TRANSPATH | MO000000058 |
--
MAPKs
--
MO000000077
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m69
10
infinite
0
TRANSPATH | MO000000077 |
--
IRF-3
--
MO000007694
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m977
10
infinite
0
InterPro | IPR008984 |
TRANSPATH | MO000007694 |
--
MyD88
--
MO000016573
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1572
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000016573 |
--
SOCS-1
--
MO000017004
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1906
10
infinite
0
InterPro | IPR001496 |
TRANSPATH | MO000017004 |
--
SOCS-3
--
MO000017121
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2005
10
infinite
0
InterPro | IPR001496 |
TRANSPATH | MO000017121 |
--
elongin C
--
MO000018946
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m3558
10
infinite
0
InterPro | IPR001232 |
TRANSPATH | MO000018946 |
--
TLR2
--
MO000019397
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m3964
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000019397 |
--
TIRAP
--
MO000022528
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m6810
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000022528 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
cytokine:Receptor:JAKs
--
e11
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m11
0
infinite
0
--
Receptor:JAKs
--
e13
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m13
0
infinite
0
--
cytokine:Receptor:Jaks
--
e14
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m14
0
infinite
0
--
cytokine:Receptor:Jaks{active}
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m15
0
infinite
0
--
cytokine:Receptor{pY}:Jaks{active}
--
e16
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m16
0
infinite
0
--
STAT dimer
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
Cytokine:receptor{pY}:JAKs{active}:STATs
--
e18
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
Cytokine:receptor{pY}:JAKs:STATs{p}
--
e19
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
STAT{p} dimer
--
e20
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m20
0
infinite
0
--
DNA:STATdimer
--
e21
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
DNA
--
e22
cso30:c:Dna
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m22
0
infinite
0
--
mRNA
--
e23
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m23
0
infinite
0
--
LPS:TLR4
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m25
0
infinite
0
--
LPS:TLR4:TIRAP
--
e26
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m26
0
infinite
0
--
LPS:TLR4:TIRAP:MyD88
--
e27
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m27
0
infinite
0
--
MAPKs{active}
--
e28
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m28
10
infinite
0
TRANSPATH | MO000000077 |
--
NF-kappaB{active}
--
e29
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m30
10
infinite
0
TRANSPATH | MO000000058 |
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
proinflammatory cytokines
--
e30
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m31
0
infinite
0
--
LPS:TLR4:TRAM
--
e31
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m32
0
infinite
0
--
LPS:TLR4:TRAM:TRIF
--
e32
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m33
0
infinite
0
--
IRF-3{active}
--
e33
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m34
10
infinite
0
InterPro | IPR008984 |
TRANSPATH | MO000007694 |
--
IFN-beta
--
e34
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m35
0
infinite
0
--
CpGmotif
--
e35
cso30:c:Dna
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m36
0
infinite
0
--
TLR9:CpGmotif
--
e36
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m37
0
infinite
0
--
Bacteria
--
e37
cso30:c:Cell
cso30:i:CC_Extracellular
--
csml-variable:Double
m38
0
infinite
0
--
CIS
--
e38
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m39
0
infinite
0
--
TNF-alpha receptor
--
e39
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m40
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
TNF-alpha:receptor
--
e40
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m41
0
infinite
0
--
SOCS-1:JAK2:Receptor
--
e41
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m42
0
infinite
0
--
Cytokine:receptor{pY}:JAKs{active}:SOCS-2
--
e42
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m43
0
infinite
0
--
SOCS-1:JAKs
--
e43
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m44
0
infinite
0
--
Cytokine:receptor{pY}:JAKs {active}:SOCS-3
--
e44
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m45
0
infinite
0
--
SOCS-3:SHP-2
--
e45
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m46
0
infinite
0
--
Cytokine:receptor{pY}:JAKs {active}:SOCS-3:SHP-2
--
e46
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m47
0
infinite
0
--
dergradants
--
e48
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
csml-variable:Double
m49
0
infinite
0
--
NF-kappaB{active}
--
e49
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m63
10
infinite
0
TRANSPATH | MO000000058 |
--
Cytokine
--
e5
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
Receptor
--
e6
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
NF-KappaB{active}:SOCS-1
--
e64
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m65
0
infinite
0
--
SOCS:Elongin B
--
e65
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m66
0
infinite
0
--
JaKs
--
e66
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m67
0
infinite
0
--
Cytokine:receptor{pY}:JAKs{active}:CIS
--
e67
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m68
0
infinite
0
--
SOCS
--
e68
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m70
0
infinite
0
--
SOCS:ElonginC
--
e69
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m71
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
IL-6:IL-6R
--
e70
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m72
0
infinite
0
--
LPS(2):TLR4(2)
--
e72
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m74
0
infinite
0
--
--
e73
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m75
0
infinite
0
--
--
e74
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m76
0
infinite
0
--
--
e75
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m77
0
infinite
0
--
microbacterial stimuli
--
e76
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m78
0
infinite
0
--
TLR3:microbacterial stimuli
--
e77
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m79
0
infinite
0
--
TLR3:miccrobial stimuli:TRIF
--
e78
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m80
0
infinite
0
--
microbial stimuli:TLR3(2)
--
e79
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m81
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
TLR2:TLR1
--
e80
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m82
0
infinite
0
--
TLR2:TLR6
--
e81
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m83
0
infinite
0
--
TLR2:TLR1:microbial stimuli
--
e82
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m84
0
infinite
0
--
TLR2:TLR6:microbial stimuli
--
e83
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m85
0
infinite
0
--
TLR2:TLR1:microbial stimuli:TIRAP
--
e84
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m86
0
infinite
0
--
TLR2:TLR6:microbial stimuli:TIRAP
--
e85
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m87
0
infinite
0
--
TLR2:TLR1:microbial stimuli:TIRAP:MyD88
--
e86
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m88
0
infinite
0
--
TLR2:TLR6:microbial stimuli:TIRAP:MyD88
--
e87
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m89
0
infinite
0
--
HPV-E7
--
e88
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m90
0
infinite
0
--
CpGmotif:TLR9(2)
--
e89
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m91
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
CpGmotif:TLR9(2):MyD88
--
e90
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m92
0
infinite
0
--
STAT{p} dimer
--
e91
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m93
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m5*m13*0.1
nodelay
--
0
PMID: 18406369 Hematopoietic cytokines act on membrane-bound receptors that lack kinase activity themselves.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m93*0.1
nodelay
--
0
PMID: 18406369 STAT dimers dissociate from the receptor and translocate to the nucleus where they act as transcription factors by binding to specific DNA sequences.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m20*m22*0.1
nodelay
--
0
PMID: 18406369 STAT dimers dissociate from the receptor and translocate to the nucleus where they act as transcription factors by binding to specific DNA sequences.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
m21*0.1
nodelay
--
0
PMID: 18406369 STAT dimers dissociate from the receptor and translocate to the nucleus where they act as transcription factors by binding to specific DNA sequences.
p13
p13
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c32 : 1
stoichiometry:c31 : 1
m1798*0.1
nodelay
--
0
PMID: 18406369 CIS also plays a role in limiting GM-CSF, IL-2, prolactin and growth hormone signaling by inhibition of STAT5 activation.
p14
p14
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1
m155666*m3961*0.1
nodelay
--
0
PMID: 18406369,9826711 Similar results were obtained for LPS-mediated activation of TLR4
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c119 : 1
stoichiometry:c38 : 1
m6810*m74*0.1
nodelay
--
0
PMID: 18406369 In the case of TLR2 and 4 this association is facilitated by TIR domain-containing adaptor/MyD88-adaptor-like protein (TIRAP/Mal).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1
m26*m1572*0.1
nodelay
--
0
PMID: 18406369 With the exception of TLR3 all TLRs use myeloid differentiation factor 88 (MyD88) as a central adaptor.
p17
p17
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c42 : 1
stoichiometry:c44 : 1
m69*m27*0.1
nodelay
--
0
PMID: 18406369 The net result is that the MyD88-dependent pathway activates MAP kinases and the NF¦ÊB signaling module
p17
p18
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1
m27*m29*0.1
nodelay
--
0
PMID: 18406369 The net result is that the MyD88-dependent pathway activates MAP kinases and the NF¦ÊB signaling module
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
m28*0.1
nodelay
--
0
PMID: 18406369 The net result is that the MyD88-dependent pathway activates MAP kinases and the NF¦ÊB signaling module
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c3 : 1
stoichiometry:c2 : 1
m6*m67*0.1
nodelay
--
0
PMID: 18406369 However, the receptor chains are tightly associated with janus kinases (JAKs)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c51 : 1
m63*0.1
nodelay
--
0
PMID: 18406369 The net result is that the MyD88-dependent pathway activates MAP kinases and the NF¦ÊB signaling module
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c150 : 1
stoichiometry:c54 : 1
m19005*m74*0.1
nodelay
--
0
PMID: 18406369 TLR3 and TLR4 further bind to TIR domain-containing protein inducing IFN-¦Â (TRIF) and the latter TLR therefore uses TRIF-related adaptor molecule in addition.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1
m18998*m32*0.1
nodelay
--
0
PMID: 18406369 TLR3 and TLR4 further bind to TIR domain-containing protein inducing IFN-¦Â (TRIF) and the latter TLR therefore uses TRIF-related adaptor molecule in addition.
p23
p23
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1
m33*m977*0.1
nodelay
--
0
PMID: 18406369 TRIF in contrast mainly activates IRF3, thereby inducing IFN-¦Â, which in turn can signal in an autocrine or paracrine manner.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
m34*0.1
nodelay
--
0
PMID: 18406369 TRIF in contrast mainly activates IRF3, thereby inducing IFN-¦Â, which in turn can signal in an autocrine or paracrine manner.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1
m36*m19828*0.1
nodelay
--
0
PMID: 18406369,11390452 Using murine macrophages and DCs, we were the first to show that triggering of TLR9 by CpG-DNA resulted in induction of SOCS1 and SOCS3
p26
p26
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1
stoichiometry:c110 : 1
m93501*m37*0.1
nodelay
--
0
PMID: 18406369,11390452 Using murine macrophages and DCs, we were the first to show that triggering of TLR9 by CpG-DNA resulted in induction of SOCS1 and SOCS3
p26
p27
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c80 : 1
m94757*m37*0.1
nodelay
--
0
PMID: 18406369,11390452 Using murine macrophages and DCs, we were the first to show that triggering of TLR9 by CpG-DNA resulted in induction of SOCS1 and SOCS3
p28
p28
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c152 : 1
stoichiometry:c112 : 1
m94757*m74*0.1
nodelay
--
0
PMID: 18406369,9826711 Similar results were obtained for LPS-mediated activation of TLR4
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1
m40*m230*0.1
nodelay
--
0
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
m14*0.1
nodelay
--
0
PMID: 18406369,10071751 Upon binding of cytokines, these receptors aggregate and perform conformational changes that lead to autoactivation of the JAKs
p28
p30
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c153 : 1
stoichiometry:c111 : 1
m93501*m74*0.1
nodelay
--
0
PMID: 18406369,9826711 Similar results were obtained for LPS-mediated activation of TLR4
p31
p31
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c67 : 1
m41*m94757*0.1
nodelay
--
0
PMID: 18406369,11727828,10606755 Moreover, it turned out that also MAP-kinase activation itself The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription, or stimulation with TNF was able to induce SOCS3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c86 : 1
m28*0.1
nodelay
--
0
PMID: 18406369,11727828,10606755 Moreover, it turned out that also MAP-kinase activation itself The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription, or stimulation with TNF was able to induce SOCS3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1
m2004*m16*0.1
nodelay
--
0
PMID: 18406369 In turn, SOCS2 and CIS interfere with STAT recruitment PMID: 18406369 SOCS2 and CIS are assumed to mainly act by competition with STAT factors for recruitment to the activated receptor complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1
m2003*m16*0.1
nodelay
--
0
PMID: 18406369 In turn, SOCS2 and CIS interfere with STAT recruitment PMID: 18406369 SOCS2 and CIS are assumed to mainly act by competition with STAT factors for recruitment to the activated receptor complex.
p35
p35
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c98 : 1
stoichiometry:c97 : 1
m1906*m130*0.1
nodelay
--
0
PMID: 18406369 In contrast, SOCS1 and SOCS3 are reported to inhibit JAK activity by use of their KIR domain PMID: 18406369 However, although it has been suggested that SOCS1 directly binds to JAK2 and acts as a pseudosubstrate, it was shown that SOCS3 binds to cytokine receptor chains with special affinity for gp130.
p35
p36
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c114 : 1
stoichiometry:c104 : 1
m1807*m2005*0.1
nodelay
--
0
PMID: 18406369 In contrast, SOCS1 and SOCS3 are reported to inhibit JAK activity by use of their KIR domain PMID: 18406369 However, although it has been suggested that SOCS1 directly binds to JAK2 and acts as a pseudosubstrate, it was shown that SOCS3 binds to cytokine receptor chains with special affinity for gp130.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c96 : 1
m2005*m16*0.1
nodelay
--
0
PMID: 18406369 In contrast, SOCS1 and SOCS3 are reported to inhibit JAK activity by use of their KIR domain PMID: 18406369 However, although it has been suggested that SOCS1 directly binds to JAK2 and acts as a pseudosubstrate, it was shown that SOCS3 binds to cytokine receptor chains with special affinity for gp130.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1
m46*m16*0.1
nodelay
--
0
PMID: 18406369 In contrast, SOCS1 and SOCS3 are reported to inhibit JAK activity by use of their KIR domain PMID: 18406369 However, although it has been suggested that SOCS1 directly binds to JAK2 and acts as a pseudosubstrate, it was shown that SOCS3 binds to cytokine receptor chains with special affinity for gp130.
p39
p39
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c74 : 1
stoichiometry:c83 : 1
m93501*m38*0.1
nodelay
--
0
PMID: 18406369,12811837 In a further study, we showed that not only various TLR ligands but also whole bacteria were able to stimulate rapid production of SOCS1, -3 and CIS
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
m11*0.1
nodelay
--
0
PMID: 18406369,10071751 Upon binding of cytokines, these receptors aggregate and perform conformational changes that lead to autoactivation of the JAKs
p39
p40
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c103 : 1
stoichiometry:c115 : 1
m38*m94757*0.1
nodelay
--
0
PMID: 18406369,12811837 In a further study, we showed that not only various TLR ligands but also whole bacteria were able to stimulate rapid production of SOCS1, -3 and CIS
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1
m38*m39*0.1
nodelay
--
0
PMID: 18406369,12811837 In a further study, we showed that not only various TLR ligands but also whole bacteria were able to stimulate rapid production of SOCS1, -3 and CIS
p42
p42
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c154 : 1
stoichiometry:c121 : 1
m130*m74*0.1
nodelay
--
0
PMID: 18406369,16287972 Recent data furthermore suggest that TLR4 stimulation might activate JAK2, thereby becoming sensitive to SOCS1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c127 : 1
m48*0.1
nodelay
--
0
PMID: 18406369,16415872 Meanwhile, another group suggested that TIRAP/Mal becomes poly-ubiquitinated and degraded by SOCS1, resulting in prolonged NF¦ÊB signaling
p44
p44
cso30:i:ME_Ubiquitination
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c122 : 1
stoichiometry:c37 : 1
m1906*m6810*0.1
nodelay
--
0
PMID: 18406369,16415872 Meanwhile, another group suggested that TIRAP/Mal becomes poly-ubiquitinated and degraded by SOCS1, resulting in prolonged NF¦ÊB signaling
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c128 : 1
m30*0.1
nodelay
--
0
PMID: 18406369 The net result is that the MyD88-dependent pathway activates MAP kinases and the NF¦ÊB signaling module
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1
m64*m63*0.1
nodelay
--
0
PMID: 18406369 Interestingly, recent results suggested that SOCS1 might be found within the nucleus where it could interact with NF¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c133 : 1
stoichiometry:c135 : 1
m3559*m70*0.1
nodelay
--
0
PMID: 18406360,12076535 It was shown that the SOCS-box associates with Elongin B and C and together with cullin-2 and Rbx1 builds up an ECS-type E3 ubiquitin ligase
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c109 : 1
stoichiometry:c136 : 1
m44*m6*0.1
nodelay
--
0
PMID: 18406369 In contrast, SOCS1 and SOCS3 are reported to inhibit JAK activity by use of their KIR domain PMID: 18406369 However, although it has been suggested that SOCS1 directly binds to JAK2 and acts as a pseudosubstrate, it was shown that SOCS3 binds to cytokine receptor chains with special affinity for gp130.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1
m70*m3558*0.1
nodelay
--
0
PMID: 18406360,12076535 It was shown that the SOCS-box associates with Elongin B and C and together with cullin-2 and Rbx1 builds up an ECS-type E3 ubiquitin ligase
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c106 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c12 : 1
m15*0.1
nodelay
--
0
PMID: 18406369 In turn, JAKs induce tyrosine phosphorylation within the receptor chains and this generates docking sites for signal transducer and activator of transcription factors (STATs)
p50
p50
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1
m871*m3096*0.1
nodelay
--
0
PMISD: 18406369 Moreover, it turned out that also MAP-kinase activation itself The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription, or stimulation with TNF was able to induce SOCS3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c146 : 1
stoichiometry:c145 : 1
m72*0.1
nodelay
--
0
PMISD: 18406369 Moreover, it turned out that also MAP-kinase activation itself The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription, or stimulation with TNF was able to induce SOCS3
p52
p52
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c151 : 1
stoichiometry:c149 : 1
m1357*m74*0.1
nodelay
--
0
PMID: 18406369 Moreover, MAP-kinase and NF¦ÊB activation were not affected, yet STAT1 tyrosine phosphorylation upon TLR triggering was inhibited.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c78 : 1
m25*0.1
nodelay
--
0
PMID: 18406369 n turn, homo- (TLR3, 4, 9) or heterodimers (TLR1, 2, 6) are activated and associate with intracellular adaptor molecules.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c125 : 1
stoichiometry:c155 : 1
m3965*m78*0.1
nodelay
--
0
PMID: 18406369 microbial stimuli directly bind to TLRs, which results in conformational changes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1
m81*m18998*0.1
nodelay
--
0
PMID: 18406369 TLR3 and TLR4 further bind to TIR domain-containing protein inducing IFN-¦Â (TRIF) and the latter TLR therefore uses TRIF-related adaptor molecule in addition.
p23
p56
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1
m80*m977*0.1
nodelay
--
0
PMID: 18406369 TRIF in contrast mainly activates IRF3, thereby inducing IFN-¦Â, which in turn can signal in an autocrine or paracrine manner.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
m79*0.1
nodelay
--
0
PMID: 18406369 n turn, homo- (TLR3, 4, 9) or heterodimers (TLR1, 2, 6) are activated and associate with intracellular adaptor molecules.
p58
p58
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1
m3964*m3963*0.1
nodelay
--
0
PMID: 18406369 In turn, homo- (TLR3, 4, 9) or heterodimers (TLR1, 2, 6) are activated and associate with intracellular adaptor molecules.
p58
p59
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1
m3964*m3987*0.1
nodelay
--
0
PMID: 18406369 In turn, homo- (TLR3, 4, 9) or heterodimers (TLR1, 2, 6) are activated and associate with intracellular adaptor molecules.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
m1633*0.1
nodelay
--
0
PMID: 18406369 According to recent research data , Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation?inactivation cycle, , STATs are found as pre-associated homo- or heterodimers in an anti-parallel conformation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1
m78*m82*0.1
nodelay
--
0
PMID: 18406369 microbial stimuli directly bind to TLRs, which results in conformational changes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1
m83*m78*0.1
nodelay
--
0
PMID: 18406369 microbial stimuli directly bind to TLRs, which results in conformational changes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1
stoichiometry:c124 : 1
m85*m6810*0.1
nodelay
--
0
PMID: 18406369 In the case of TLR2 and 4 this association is facilitated by TIR domain-containing adaptor/MyD88-adaptor-like protein (TIRAP/Mal).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1
m84*m6810*0.1
nodelay
--
0
PMID: 18406369 In the case of TLR2 and 4 this association is facilitated by TIR domain-containing adaptor/MyD88-adaptor-like protein (TIRAP/Mal).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c183 : 1
stoichiometry:c185 : 1
m86*m1572*0.1
nodelay
--
0
PMID: 18406369 With the exception of TLR3 all TLRs use myeloid differentiation factor 88 (MyD88) as a central adaptor.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c184 : 1
stoichiometry:c186 : 1
m87*m1572*0.1
nodelay
--
0
PMID: 18406369 With the exception of TLR3 all TLRs use myeloid differentiation factor 88 (MyD88) as a central adaptor.
p17
p66
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c193 : 1
stoichiometry:c194 : 1
m89*m29*0.1
nodelay
--
0
PMID: 18406369 The net result is that the MyD88-dependent pathway activates MAP kinases and the NF¦ÊB signaling module
p17
p67
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1
m88*m29*0.1
nodelay
--
0
PMID: 18406369 The net result is that the MyD88-dependent pathway activates MAP kinases and the NF¦ÊB signaling module
p17
p68
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1
m89*m69*0.1
nodelay
--
0
PMID: 18406369 The net result is that the MyD88-dependent pathway activates MAP kinases and the NF¦ÊB signaling module
p17
p69
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c195 : 1
stoichiometry:c196 : 1
m88*m69*0.1
nodelay
--
0
PMID: 18406369 The net result is that the MyD88-dependent pathway activates MAP kinases and the NF¦ÊB signaling module
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c17 : 1
m16*m17*0.1
nodelay
--
0
PMID: 18406369 In turn, JAKs induce tyrosine phosphorylation within the receptor chains and this generates docking sites for signal transducer and activator of transcription factors (STATs) PMID: 18406369 Upon cytokine receptor stimulation, STAT dimers change their conformation towards a parallel one and bind to tyrosine-phosphorylated cytokine receptor chains by use of their Src homology 2 (SH2) domain. PMID: 18406369 In turn, SOCS2 and CIS interfere with STAT recruitment PMID: 18406369 SOCS2 and CIS are assumed to mainly act by competition with STAT factors for recruitment to the activated receptor complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1
m37*0.1
nodelay
--
0
PMID: 18406369 n turn, homo- (TLR3, 4, 9) or heterodimers (TLR1, 2, 6) are activated and associate with intracellular adaptor molecules.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c202 : 1
stoichiometry:c203 : 1
m91*m1572*0.1
nodelay
--
0
PMID: 18406369 With the exception of TLR3 all TLRs use myeloid differentiation factor 88 (MyD88) as a central adaptor.
p17
p72
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c205 : 1
stoichiometry:c206 : 1
m92*m69*0.1
nodelay
--
0
PMID: 18406369 The net result is that the MyD88-dependent pathway activates MAP kinases and the NF¦ÊB signaling module
p17
p73
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1
m92*m29*0.1
nodelay
--
0
PMID: 18406369 The net result is that the MyD88-dependent pathway activates MAP kinases and the NF¦ÊB signaling module
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c212 : 1
stoichiometry:c211 : 1
m90*m70*0.1
nodelay
--
0
PMID: 18406369,15021916 It was reported that human papilloma virus (HPV) E7 protein could be degraded by SOCS expression, resulting in a loss of proliferation of HPV-transformed HeLa cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
m18*0.1
nodelay
--
0
PMID: 18406369 In turn, STATs are tyrosine phosphorylated by JAKs, which uncovers a nuclear localization signal.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c22 : 1
stoichiometry:c21 : 1
m19*0.1
nodelay
--
0
PMID: 18406369 STAT dimers dissociate from the receptor and translocate to the nucleus where they act as transcription factors by binding to specific DNA sequences.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--